91,289 results match your criteria Arthritis Research & Therapy[Journal]


Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

J Ethnopharmacol 2019 Apr 21:111902. Epub 2019 Apr 21.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China. Electronic address:

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by failure of spontaneous resolution of inflammation. The stem of Kadsura heteroclite (KHS) is a well-known anti-arthritic Tujia ethnomedicinal plant, which named Xuetong in folk, has long been used for the prevention and treatment of rheumatic and arthritic diseases.

Aim Of The Study: The analgesic and anti-inflammatory effects and the potential mechanisms behind such effects of KHS would be investigated by using different animal models. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111902DOI Listing

Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.

Ann Noninvasive Electrocardiol 2019 Apr 24:e12651. Epub 2019 Apr 24.

Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.

Background: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown.

Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders.

Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. Read More

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http://dx.doi.org/10.1111/anec.12651DOI Listing

Rituximab in connective tissue disease-associated interstitial lung disease.

Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

Rheumatology Department, Hospital Garcia de Orta EPE, Avenida Torrado da Silva, 2805-267, Almada, Portugal.

Introduction/objectives: To evaluate rituximab (RTX) effectiveness and safety in patients with interstitial lung disease (ILD) related to connective tissue diseases (CTD).

Methods: Retrospective multicenter cohort study, including patients with CTD-ILD, followed in six Portuguese rheumatology departments until November 2018. ILD diagnosis was based on high-resolution CT (HRCT) and/or lung biopsy. Read More

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http://link.springer.com/10.1007/s10067-019-04557-7
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http://dx.doi.org/10.1007/s10067-019-04557-7DOI Listing
April 2019
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Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR.

Clin Rheumatol 2019 Apr 17. Epub 2019 Apr 17.

Santiago University Clinical Hospital Institute of Medical Research, Santiago de Compostela, Spain.

Objective: Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries. Read More

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http://dx.doi.org/10.1007/s10067-019-04516-2DOI Listing

Dopaminergic Agents in Rheumatoid Arthritis.

Authors:
Silvia Capellino

J Neuroimmune Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Junior Group Neuroimmunology, Department of Immunology, IfADo - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

Clinical evidences suggest a causal relationship between rheumatoid arthritis (RA) and the dopaminergic system, and several studies described an alteration of the disease in patients treated with dopaminergic agents. Despite these interesting results, potential direct effects of dopamine on RA have not been intensively considered until the last decade. Recent studies confirm a direct effect of dopamine on the systemic immune response as well as on bone remodeling and on joint inflammation, both in humans and in different animal models of arthritis. Read More

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http://dx.doi.org/10.1007/s11481-019-09850-5DOI Listing

Comparative Evaluation of Ga-Citrate PET/CT and F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats.

Contrast Media Mol Imaging 2019 19;2019:2353658. Epub 2019 Mar 19.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. Read More

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http://dx.doi.org/10.1155/2019/2353658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231PMC

Hes1 attenuates type I IFN responses via VEGF-C and WDFY1.

J Exp Med 2019 Apr 23. Epub 2019 Apr 23.

Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China

Induction of type I interferons (IFNs) is critical for eliciting competent immune responses, especially antiviral immunity. However, uncontrolled IFN production contributes to pathogenesis of autoimmune and inflammatory diseases. We found that transcription factor Hes1 suppressed production of type I IFNs and expression of IFN-stimulated genes. Read More

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http://dx.doi.org/10.1084/jem.20180861DOI Listing

Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy.

J Control Release 2019 Apr 20. Epub 2019 Apr 20.

Department of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Owing to its intricate autoimmune pathophysiology and significant risks of progression to other rheumatic co-morbidities (i.e., osteoporosis and osteoarthritis), a plausible therapeutic regimen is mandatory for early-stage management of rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.027DOI Listing

Isolation and Characterisation of Major and Minor Collagens from Hyaline Cartilage of Hoki ().

Mar Drugs 2019 Apr 12;17(4). Epub 2019 Apr 12.

Seafood Research Unit, The New Zealand Institute for Plant and Food Research Limited, PO Box 5114, Port Nelson 7043, New Zealand.

The composition and properties of collagen in teleost (bony fish) cartilage have never been studied. In this study, we aimed to identify and characterise all collagen species in the nasal cartilage of hoki (). Four native collagen species were extracted using two techniques, and isolated with differential salt precipitation. Read More

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http://dx.doi.org/10.3390/md17040223DOI Listing

Could Polyphenols Help in the Control of Rheumatoid Arthritis?

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

College of Korean Medicine, Kyung Hee University, Seoul, Seoul 02453, Korea.

Rheumatoid arthritis (RA) is a chronic, systemic, joint-invading, autoimmune inflammatory disease, which causes joint cartilage breakdown and bone damage, resulting in functional impairment and deformation of the joints. The percentage of RA patients has been rising and RA represents a substantial burden for patients around the world. Despite the development of many RA therapies, because of the side effects and low effectiveness of conventional drugs, patients still need and researchers are seeking new therapeutic alternatives. Read More

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http://dx.doi.org/10.3390/molecules24081589DOI Listing

Muscle Strength and Functional Ability in Recreational Female Golfers and Less Active Non-Golfers over the Age of 80 Years.

Geriatrics (Basel) 2017 Mar 4;2(1). Epub 2017 Mar 4.

Faculty of Health Sciences, Building 45, University of Southampton, Southampton SO17 1BJ, UK.

Muscle strength and functional ability decline with age. Physical activity can slow the decline but whether recreational golf is associated with slower decline is unknown. This cross-sectional, observational study aimed to examine the feasibility of testing muscle strength and functional ability in older female golfers and non-golfers in community settings. Read More

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http://dx.doi.org/10.3390/geriatrics2010012DOI Listing

Anterior Thigh Tissue Thickness Measured Using Ultrasound Imaging in Older Recreational Female Golfers and Sedentary Controls.

Geriatrics (Basel) 2017 Feb 7;2(1). Epub 2017 Feb 7.

Faculty of Health Sciences, Building 45, University of Southampton, Southampton SO17 1BJ, UK.

Physical activity is vital for the prevention of sarcopenia and frailty. The training effects of recreational golf on muscle function in older people are unknown. The present study examined quadriceps muscle and subcutaneous fat thickness in 66 older females. Read More

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http://dx.doi.org/10.3390/geriatrics2010010DOI Listing
February 2017

Acupressure treatment for methotrexate-induced nausea in arthritis patients.

Authors:
A Lind T Weitoft

Scand J Rheumatol 2019 Apr 23:1-2. Epub 2019 Apr 23.

a Center for Research and Development , Uppsala University/Region Gävleborg , Gävle , Sweden.

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http://dx.doi.org/10.1080/03009742.2019.1579860DOI Listing

Serum drug concentrations to optimize switching from adalimumab to etanercept in rheumatoid arthritis.

Scand J Rheumatol 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Rheumatology , Amsterdam Rheumatology and Immunology Center , Reade , Amsterdam , The Netherlands.

Objectives: Inadequate response to adalimumab can be caused by insufficient blockade of the target tumour necrosis factor (TNF) at low serum concentrations. In such cases, patients may respond to another TNF inhibitor. We investigated whether the serum adalimumab concentration is related to the efficacy of a second TNF inhibitor, etanercept, in rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1080/03009742.2019.1577915DOI Listing

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

Correction to: Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn's Disease: An Integrated Analysis of Phase II/III Clinical Development Programs.

Drug Saf 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology, University of Connecticut Health Center, 21 South Road, 2nd Floor, Farmington, CT, 06030, USA.

In the original publication of this article, the following correction should be noted in Table 5. Read More

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http://dx.doi.org/10.1007/s40264-019-00816-3DOI Listing

Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

GC B cells 'AKT' to blunt BCR signaling.

Authors:
Julie Zikherman

Nat Immunol 2019 Apr 22. Epub 2019 Apr 22.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41590-019-0384-3DOI Listing
April 2019
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Age- and gender-stratified adult myometric reference values of isometric intrinsic hand strength.

J Hand Ther 2019 Apr 19. Epub 2019 Apr 19.

Madison Metropolitan School District, Madison, WI, USA.

Study Design: Descriptive normative.

Introduction: Intrinsic hand strength can be impacted by hand arthritis, peripheral nerve injuries, and spinal cord injuries. Grip dynamometry does not isolate intrinsic strength, and manual muscle testing is not sensitive to change in grades 4 and 5. Read More

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http://dx.doi.org/10.1016/j.jht.2019.03.005DOI Listing

Research Techniques Made Simple: Mouse Models of Atopic Dermatitis.

J Invest Dermatol 2019 May 19;139(5):984-990.e1. Epub 2019 Apr 19.

Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have been heavily used to deepen our understanding of complicated disease mechanisms in AD and to provide a preclinical platform before performing clinical interventional research on novel therapeutic agents in humans. However, what aspects of human AD these mouse AD models faithfully recapitulate is insufficiently understood. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.014DOI Listing

The Antioxidant from Ethanolic Extract of Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.

Tratt is a Chinese herbal remedy that is used in the treatment of diarrhea, burns, rheumatoid arthritis, and hemorrhage. Despite its use in Asian folk medicine, there are limited reports on the biological activity of fruits. This study focused on the investigation of the antitumor effect of the antioxidative ethanolic extract of fruits (RCE) along with its underlying mechanism of action. Read More

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http://dx.doi.org/10.3390/ijms20081935DOI Listing

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Eur Stroke J 2017 Sep 21;2(3):250-256. Epub 2017 Apr 21.

Division of Epidemiology & Public Health, University of Nottingham, Nottingham, UK.

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women of childbearing age in Sweden.

Patients And Methods: All women aged 15-49 years with live births/stillbirths in 1992-2011 were identified from the Swedish Medical Birth Registry linked with the National Patient Registry. First stroke during the study period was identified. Read More

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http://dx.doi.org/10.1177/2396987317706600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454822PMC
September 2017

National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

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http://dx.doi.org/10.7326/M19-0961DOI Listing

Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity.

Ecotoxicol Environ Saf 2019 Apr 19;178:211-220. Epub 2019 Apr 19.

Beijing Jishuitan Hospital, Peking University Health Science Center, Beijing, 100035, PR China. Electronic address:

Due to similar aerodynamic and micro-nano sized properties between airborne particles and synthetic nanoparticles, a large number of studies have been conducted using carbon-based particles, such as carbon black (CB), carbon nanotubes and graphite, in order to achieve deeper understandings of their adverse effects on human health. It has been reported that particulate matters can aggravate morbidity of patients suffering from bone and joint diseases, e.g. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.029DOI Listing
April 2019
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Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI.

Osteoarthritis Cartilage 2019 Apr 19. Epub 2019 Apr 19.

Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, USA; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, USA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA; Department of Orthopedic Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Health and Exercise Science, J. B. Snow Biomechanics Laboratory, Wake Forest University, Winston-Salem, USA.

Objective: Diet restriction and exercise form key treatments for osteoarthritis (OA) related symptoms in overweight and obese individuals. Although both interventions are known to influence systemic low-grade inflammation, which is related to pain levels and functional limitations, little is known about the potential changes in systemic inflammation as a working mechanism of diet restriction and exercise in knee OA.

Design: Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.009DOI Listing

Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

Attitudes towards Oral Health in Patients with Rheumatoid Arthritis: A Qualitative Study Nested within a Randomized Controlled Trial.

JDR Clin Trans Res 2019 Apr 22:2380084419833694. Epub 2019 Apr 22.

1 Periodontal Research Group, School of Dentistry, Institute of Clinical Sciences, University of Birmingham, and Birmingham Dental Hospital (Birmingham Community Healthcare NHS Foundation Trust), Edgbaston, Birmingham, UK.

Introduction: Patients with rheumatoid arthritis (RA) present a higher incidence and severity of periodontitis than the general population. Our study, Outcomes of Periodontal Treatment in Patients with Rheumatoid Arthritis (OPERA), was a randomized waiting-list controlled trial using mixed methods. Patients randomized to the intervention arm received intensive periodontal treatment, and those in the control arm received the same treatment with a 6-mo delay. Read More

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http://dx.doi.org/10.1177/2380084419833694DOI Listing

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A, a key cytokine involved in psoriasis (PsO) and psoriatic arthritis (PsA) development, and has shown rapid and long lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Monoclonal antibody therapies may be associated with the production of treatment-emergent anti-drug antibodies (TE-ADA) that can affect drug pharmacokinetics, diminish clinical responses via inhibition of target binding, or cause hypersensitivity reactions. Secukinumab exhibited minimal immunogenicity up to 52 weeks in patients with moderate-to-severe plaque psoriasis, as evidenced by TE-ADA in <1% patients. Read More

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http://dx.doi.org/10.1111/jdv.15637DOI Listing

Evaluation of the Painful Total Knee Arthroplasty.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Beaumont Health, Departments of Orthopaedic Surgery and Research, Royal Oak, MI (Dr. Flierl, Dr. Sobh, and Dr. Baker), the Princeton HealthCare System, Department of Orthopaedic Surgery, Princeton, NJ (Dr. Culp), and the Rush University Medical Center, Midwest Orthopaedics at Rush, Chicago, IL (Dr. Sporer).

Total knee arthroplasty (TKA) has been associated with notable improvements in health-related quality of life of patients with end-stage knee arthritis. Although most patients experience substantial symptomatic relief after TKA, up to 19% of patients are unsatisfied with their outcome. With the dramatic, projected increase in the number of TKAs performed annually, it is crucial to appreciate the various modes of failure associated with this procedure. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00083DOI Listing

Acute Flares of Knee Osteoarthritis (the ACT-FLARE Study): Protocol for a Web-Based Case-Crossover Study in Community-Dwelling Adults.

JMIR Res Protoc 2019 Apr 22;8(4):e13428. Epub 2019 Apr 22.

Primary Care Centre Versus Arthritis, Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom.

Background: The cardinal feature of osteoarthritis (OA) is pain. Although heterogeneity in pain and function have been demonstrated in the long-term course of OA, the more proximate determinants of acute flare-ups remain less clear. How short-term intermittent or transient exposures trigger acute flare-ups has important implications for effective and sustainable self-management strategies. Read More

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https://www.researchprotocols.org/2019/4/e13428/
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http://dx.doi.org/10.2196/13428DOI Listing
April 2019
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Depression and multimorbidity: Considering temporal characteristics of the associations between depression and multiple chronic diseases.

Health Psychol 2019 Apr 22. Epub 2019 Apr 22.

Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center.

Objectives: Depression frequently co-occurs with multiple chronic diseases in complex, costly, and dangerous patterns of multimorbidity. The field of health psychology may benefit from evaluating the temporal characteristics of depression's associations with common diseases, and from determining whether depression is a central connector in multimorbid disease clusters. The present review addresses these issues by focusing on 4 of the most prevalent diseases: hypertension, ischemic heart disease, arthritis, and diabetes. Read More

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http://dx.doi.org/10.1037/hea0000737DOI Listing

Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD.

Background: Scleromyxedema (SMX) is a rare systemic sclerosis mimic that often responds to intravenous immunoglobulin therapy (IVIG), yet the resulting clinical and biochemical changes have not been well characterized.

Methods: Fifteen patients with SMX were recruited for the study. Clinical information and peripheral blood mononuclear cells for flow cytometry were obtained immediately before and again 1-2 weeks after receiving IVIG therapy. Read More

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http://dx.doi.org/10.1002/acr.23908DOI Listing

Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Objectives: Individuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early-onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary "idiopathic" systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. Read More

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http://dx.doi.org/10.1002/art.40913DOI Listing

Associations of joint line tenderness and patellofemoral grind with long-term knee joint outcomes: Data from the Osteoarthritis Initiative.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.

Objective: To examine whether joint line tenderness and patellofemoral grind from physical examination were associated with cartilage volume loss, worsening of radiographic osteoarthritis, and risk of total knee replacement.

Methods: This study examined 4353 Osteoarthritis Initiative participants. For each of joint line tenderness and patellofemoral grind, the patterns were defined as no (none at baseline and 1-year), fluctuating (present at either time-point), and persistent (present at both time-points). Read More

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http://dx.doi.org/10.1002/acr.23906DOI Listing

Birt-Hogg-Dubé syndrome initially diagnosed as tuberous sclerosis complex.

JAAD Case Rep 2019 Apr 5;5(4):368-371. Epub 2019 Apr 5.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453834PMC

IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors.

Am J Hum Genet 2019 Apr 6. Epub 2019 Apr 6.

Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

Despite significant progress in annotating the genome with experimental methods, much of the regulatory noncoding genome remains poorly defined. Here we assert that regulatory elements may be characterized by leveraging local epigenomic signatures where specific transcription factors (TFs) are bound. To link these two features, we introduce IMPACT, a genome annotation strategy that identifies regulatory elements defined by cell-state-specific TF binding profiles, learned from 515 chromatin and sequence annotations. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.03.012DOI Listing

Successful treatment of arthritis and rash with tofacitinib in systemic lupus erythematosus: the experience from a single centre.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21545
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http://dx.doi.org/10.1136/annrheumdis-2019-215455DOI Listing
April 2019
3 Reads

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
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http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Pathogenic effector functions of ACPA: Where do we stand?

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Medicine, Duke University Medical Center and Medical Research Service, VA Medical Center, Durham, North Carolina, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21533
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http://dx.doi.org/10.1136/annrheumdis-2019-215337DOI Listing
April 2019
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Ethanolic extract of Kaempferia parviflora interrupts the mechanisms-associated rheumatoid arthritis in SW982 culture model via p38/STAT1 and STAT3 pathways.

Phytomedicine 2018 Nov 14;59:152755. Epub 2018 Nov 14.

Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Background: Kaempferia parviflora Wall. ex Baker (KP) has long been used in traditional medicine to treat various diseases because active compounds in rhizome extracts are important anti-inflammatory agents.

Purpose: This study aims to investigate the effects of an ethanolic extract of KP on the molecular mechanisms associated with rheumatoid arthritis (RA), which was induced by a combination of proinflammatory cytokines (IL-1β or TNF-α with IL-17A) in a human synovial sarcoma cell line (SW982) culture model. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.015DOI Listing
November 2018

Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales.

Lancet Infect Dis 2019 Apr 17. Epub 2019 Apr 17.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. Electronic address:

Background: Prosthetic joint infection is a devastating complication of knee replacement. The risk of developing a prosthetic joint infection is affected by patient, surgical, and health-care system factors. Existing evidence is limited by heterogeneity in populations studied, short follow-up, inadequate power, and does not differentiate early prosthetic joint infection, most likely related to the intervention, from late infection, more likely to occur due to haematogenous bacterial spread. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30755-2DOI Listing

Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis.

J Clin Densitom 2019 Mar 28. Epub 2019 Mar 28.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.

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http://dx.doi.org/10.1016/j.jocd.2019.03.008DOI Listing

The present and future of deep learning in radiology.

Eur J Radiol 2019 May 2;114:14-24. Epub 2019 Mar 2.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

The advent of Deep Learning (DL) is poised to dramatically change the delivery of healthcare in the near future. Not only has DL profoundly affected the healthcare industry it has also influenced global businesses. Within a span of very few years, advances such as self-driving cars, robots performing jobs that are hazardous to human, and chat bots talking with human operators have proved that DL has already made large impact on our lives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193009
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http://dx.doi.org/10.1016/j.ejrad.2019.02.038DOI Listing
May 2019
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Influence Of Age, Sex And Generation On Physician Payments And Clinical Activity In Ontario, Canada: An Age-Period-Cohort Analysis.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology and Visual Sciences, University of Toronto, 340 College Street, Suite 400, Toronto, Ontario, Canada M5T 3A9; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.

Purpose: To compare the effect of age, sex and generation on physician practice patterns in Ontario, Canada.

Design: Retrospective cohort study.

Methods: Physician and patient data from 1992-2013 were used to calculate yearly number of physicians, distinct patients seen, patient visits, government payments, physician age, sex, specialty and year of birth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193018
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http://dx.doi.org/10.1016/j.ajo.2019.04.006DOI Listing
April 2019
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Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

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http://dx.doi.org/10.1007/s11306-019-1527-0DOI Listing
April 2019
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Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.

ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing ανβ3 and α5β1 and their mediators to trigger inflammation. ανβ3 and α5β1 facilitate cells-ECM and cell-cell communication, producing pro-inflammatory factors. Read More

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https://www.mdpi.com/1420-3049/24/8/1537
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http://dx.doi.org/10.3390/molecules24081537DOI Listing
April 2019
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Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

To study new target-oriented molecules that are active against rheumatoid arthritis-dependent pain, new dual inhibitors incorporating both a carbonic anhydrase (CA)-binding moiety and a cyclooxygenase inhibitor (NSAID) were tested in a rat model of rheumatoid arthritis induced by CFA intra-articular (i.a.) injection. Read More

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http://dx.doi.org/10.3390/ijms20081923DOI Listing
April 2019
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A machine learning approach to knee osteoarthritis phenotyping: Data from the FNIH Biomarkers Consortium.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping in order to define progression phenotypes that are potentially more responsive to interventions.

Design: We used publicly available data from the FNIH OA Biomarkers Consortium, where radiographic (medial joint space narrowing of ≥0. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.027DOI Listing

Prevalence and predictors for sustained remission in rheumatoid arthritis.

PLoS One 2019 19;14(4):e0214981. Epub 2019 Apr 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Objective: Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214981PLOS
April 2019
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3.234 Impact Factor

Moderate-to-severe psoriasis and pregnancy: impact on fertility, pregnancy outcome and treatment perspectives.

G Ital Dermatol Venereol 2019 Jun;154(3):305-314

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Psoriasis affects 2-4% of the world's population, with no difference between men and women and 70% of patients experiencing disease onset before the age of 40, which coincides with the reproductive years. Few data are available from literature on impact of psoriasis on fertility, course and outcome of pregnancy and risk associated with treatments. Recent studies on other immune-mediated inflammatory diseases, among which psoriasis is also included, indicate that rheumatoid arthritis and inflammatory bowel diseases can impact female fertility and pregnancy outcomes especially during active disease episodes. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2019N03A030
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http://dx.doi.org/10.23736/S0392-0488.18.06255-7DOI Listing
June 2019
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