Front Chem 2022 10;10:878811. Epub 2022 May 10.
TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
A pair of 3,4--cycloartane triterpenoid isomers with a rare peroxy bridge, namely, xuetonins A and B ( and ), four new lignans xuetonlignans A-D (-), a new sesquiterpene xuetonpene (), and a new natural product xuetonin C (), along with 43 known compounds, were obtained from the leaves of Tujia ethnomedicine, . Their structures and configurations were determined with the help of a combination of 1D- and 2D-NMR, HRESIMS spectra, electronic circular dichroism (ECD), and X-ray diffraction data. Compounds , , -, and - showed moderate-to-potent activity against rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) with IC values of 19. Read More