27,020 results match your criteria Arthritis Care & Research[Journal]


Prevalence and correlates of falls in a middle-aged population with osteoarthritis: Data from the Osteoarthritis Initiative.

Health Soc Care Community 2020 Jul 14. Epub 2020 Jul 14.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.

People with osteoarthritis (OA) are at a higher risk of falls and fall-related injuries. However, there is limited knowledge of the burden and correlates of falls in middle-aged people with OA. Using data from the Osteoarthritis Initiative, this study aimed to determine the prevalence and correlates of falls among middle-aged people with OA. Read More

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http://dx.doi.org/10.1111/hsc.13103DOI Listing

Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.

Diabetes Metab J 2020 Jul 13. Epub 2020 Jul 13.

Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.

Background: No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that have been documented as potential biomarkers for various diseases. Our objective was to identify and analyze plasma circRNAs altered in T1DM. Read More

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http://dx.doi.org/10.4093/dmj.2019.0151DOI Listing

Prevalence of Malignancy Among Urban Black Rheumatoid Arthritis Patients.

Int J Clin Res Trials 2020 25;5(1). Epub 2020 Apr 25.

Department of Medicine, Division of Pulmonary and Critical Care State, SUNY Downstate Medical Center/Health and Hospitals Kings County, Brooklyn, NY 11203, USA.

Background: Rheumatoid arthritis (RA) patients have an increased risk of malignancy with postulated risk factors that include chronic inflammation, smoking and the use of immunosuppressants have been postulated as drivers of higher malignancies rates. Our study aimed to describe the prevalence and type of malignancies encountered in an urban, predominantly Black RA patient population.

Methods: Cross sectional analysis of 1142 patients with RA diagnosis by ICD-codes of which 501 cases met the inclusion criteria for the study. Read More

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http://dx.doi.org/10.15344/2456-8007/2020/145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357963PMC

Core and adjunctive interventions for osteoarthritis: efficacy and models for implementation.

Nat Rev Rheumatol 2020 Jul 13. Epub 2020 Jul 13.

Institute of Bone and Joint Research, The University of Sydney, Kolling Institute, St Leonards, NSW, Australia.

Osteoarthritis (OA) is a complex musculoskeletal disease and a leading cause of pain and disability worldwide. Hip and knee OA alone are major contributors to global disability, having notable effects on individual well-being, increasing the reliance of individuals on health-care services and contributing to a rise in the socioeconomic burden. Consistent, coordinated and tailored approaches are important for providing appropriate care to all people with OA, but despite the scale of the challenge many individuals are still not offered the safe, best-evidence treatments recommended for OA care. Read More

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http://dx.doi.org/10.1038/s41584-020-0447-8DOI Listing

Gender Differences in Hispanic Patients of Mexican Origin Hospitalized with Heart Failure.

Womens Health Issues 2020 Jul 10. Epub 2020 Jul 10.

University of Wisconsin - Madison, School of Nursing, Madison, Wisconsin.

Background: More than 3 million women in the United States die of heart failure (HF) annually. Women are significantly underrepresented in studies that inform practice guidelines, especially women hospitalized for HF despite the associated negative outcomes. HF is common in Hispanics, the largest ethnic minority group in the United States, who are mostly of Mexican origin. Read More

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http://dx.doi.org/10.1016/j.whi.2020.06.002DOI Listing

Rheumatoid Arthritis and CLOVES Syndrome: A Tricky Diagnosis.

Diagnostics (Basel) 2020 Jul 9;10(7). Epub 2020 Jul 9.

Department of Molecular Sciences, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj, 6, Pasteur St., 400349 Cluj-Napoca, Romania.

The PI3K/AKT/mTOR signaling pathway is significantly activated in rheumatoid arthritis. In addition, somatic activating mutations of the PI3K/AKT/mTOR pathway may result in -related overgrowth spectrum diseases, including CLOVES (Congenital Lipomatous Overgrowth, Vascular malformation, Epidermal nevi, Skeletal abnormalities/Scoliosis) syndrome. We describe the case of a young female patient, with anti-citrullinated peptide antibodies-positive rheumatoid arthritis, referred for persistent finger pain and stiffness. Read More

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http://dx.doi.org/10.3390/diagnostics10070467DOI Listing

Comparison of Health Outcomes Among High- and Low-Income Adults Aged 55 to 64 Years in the US vs England.

JAMA Intern Med 2020 Jul 13. Epub 2020 Jul 13.

Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor.

Importance: Socioeconomic differences in life expectancy, health, and disability have been found in European countries as well as in the US. Identifying the extent and pattern of health disparities, both within and across the US and England, may be important for informing public health and public policy aimed at reducing these disparities.

Objective: To compare the health of US adults aged 55 to 64 years with the health of their peers in England across the high and low ranges of income in each country. Read More

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http://dx.doi.org/10.1001/jamainternmed.2020.2802DOI Listing

Tackling global challenges in pediatric rheumatology.

Curr Opin Rheumatol 2020 Jul 9. Epub 2020 Jul 9.

National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, DHHS, Bethesda, Maryland, USA.

Recent Findings: Recent studies and reports demonstrate a paucity of studies on epidemiology, outcomes, and management guidelines from many regions of the world. There have been noteworthy efforts to bridge the gap in under resourced areas. An analysis of the global burden of rheumatic disease has demonstrated that while understudied, musculoskeletal diseases are prevalent and increasingly contribute to loss of years of healthy life. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000726DOI Listing

Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis.

Ther Deliv 2020 Jul 13. Epub 2020 Jul 13.

Transducer Engineering Inc., Andover, MA 01810, USA.

Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Read More

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http://dx.doi.org/10.4155/tde-2020-0009DOI Listing

Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair.

Orthop J Sports Med 2020 Jul 1;8(7):2325967120927655. Epub 2020 Jul 1.

Investigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.

Background: A bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR) procedure places an extracellular matrix implant, combined with autologous whole blood, in the gap between the torn ends of the ligament at the time of suture repair to stimulate healing. Prior studies have suggested that white blood cell (WBC) and platelet concentrations significantly affect the healing of other musculoskeletal tissues.

Purpose/hypothesis: The purpose of this study was to determine whether concentrations of various blood cell types placed into a bridging extracellular matrix implant at the time of ACL repair would have a significant effect on the healing ligament cross-sectional area or tissue organization (as measured by signal intensity). Read More

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http://dx.doi.org/10.1177/2325967120927655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331772PMC

Quantification of citrullinated histones: development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

EpiCypher Inc, Durham, North Carolina, USA.

Background: Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered by lack of standardized assays.

Objectives: We aimed to develop an assay to reliably quantify nucleosomal H3Cit in human plasma. Read More

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http://dx.doi.org/10.1111/jth.15003DOI Listing

Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes.

Rheumatol Int 2020 Jul 11. Epub 2020 Jul 11.

Joint Rheumatology Program, First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens Medical School, 17 Agiou Thoma Street, 11527, Athens, Greece.

As of June 10th 2020 about 7.2 million individuals have tested positive for, and more than 410,000 have died due to COVID-19. In this review we outline the pathophysiology that underpins the potential use of anti-rheumatic therapies for severe COVID-19 infection and summarize the current evidence regarding the risk and outcome of COVID-19 in patients with systemic autoimmune diseases. Read More

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http://dx.doi.org/10.1007/s00296-020-04629-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353833PMC

Comparison of paediatric and adult classification criteria in juvenile idiopathic arthritis during the transition from paediatric to adult care.

Joint Bone Spine 2020 Jul 9. Epub 2020 Jul 9.

Department of Rheumatology, Lyon University Hospital and University of Lyon 1, France. Electronic address:

Objectives: To determine the characteristics of juvenile idiopathic arthritis (JIA) patients seen during the transition period in order to compare paediatric classification criteria with those for adults.

Methods: Patients with JIA according to the ILAR classification and who had a consultation at transition between 2010 and 2017 were included in a retrospective bi-centre (Lyon, Lausanne) study. JIA classification criteria were compared to ACR/EULAR 2010 criteria for rheumatoid arthritis (RA), Yamaguchi criteria for adult-onset Still's disease (AOSD), ASAS criteria for spondyloarthritis and CASPAR criteria for psoriatic arthritis. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.06.020DOI Listing

Initiating guideline-concordant gout treatment improves arterial endothelial function and reduces intercritical inflammation: a prospective observational study.

Arthritis Res Ther 2020 Jul 11;22(1):169. Epub 2020 Jul 11.

Section of Rheumatology, VA New York Harbor Health Care System, New York, NY, USA.

Background: Patients with gout have arterial dysfunction and systemic inflammation, even during intercritical episodes, which may be markers of future adverse cardiovascular outcomes. We conducted a prospective observational study to assess whether initiating guideline-concordant gout therapy with colchicine and a urate-lowering xanthine oxidase inhibitor (XOI) improves arterial function and reduces inflammation.

Methods: Thirty-eight untreated gout patients meeting American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for gout and ACR guidelines for initiating urate-lowering therapy (ULT) received colchicine (0. Read More

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http://dx.doi.org/10.1186/s13075-020-02260-6DOI Listing

The Difference in Medial Meniscal Extrusion between Non-Weight-Bearing and Weight-Bearing Positions in People with and without Medial Compartment Knee Osteoarthritis.

PM R 2020 Jul 11. Epub 2020 Jul 11.

Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Background: Medial meniscal extrusion (MME) has been correlated with medial meniscal injury and progression of medial knee osteoarthritis (OA).

Objective: Examine the difference in MME between non-weight-bearing (supine) and weight-bearing (standing) positions in subjects with and without medial knee OA. Determine the correlation between body mass index (BMI), Kellgren/Lawrence (KL) grade, Knee Osteoarthritis Outcome Score (KOOS) and MME. Read More

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http://dx.doi.org/10.1002/pmrj.12450DOI Listing

Ultra-fast detection and quantification of nucleic acids by amplification-free fluorescence assay.

Analyst 2020 Jul 10. Epub 2020 Jul 10.

Department of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800 Kgs. Lyngby, Denmark.

Two types of clinically important nucleic acid biomarkers, microRNA (miRNA) and circulating tumor DNA (ctDNA) were detected and quantified from human serum using an amplification-free fluorescence hybridization assay. Specifically, miRNAs hsa-miR-223-3p and hsa-miR-486-5p with relevance for rheumatoid arthritis and cancer related mutations BRAF and KRAS of ctDNA were directly measured. The required oligonucleotide probes for the assay were rationally designed and synthesized through a novel "clickable" approach which is time and cost-effective. Read More

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http://dx.doi.org/10.1039/d0an00676aDOI Listing

Efficacy and Safety of Canakinumab in sJIA Patients with and without Fever at Baseline: Results from an Open-label, Active Treatment Extension Study.

Arthritis Rheumatol 2020 Jul 10. Epub 2020 Jul 10.

IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy.

Objective: To evaluate the long-term efficacy, safety of canakinumab and explore prediction of response in systemic juvenile idiopathic arthritis (sJIA) patients with and without fever at treatment initiation.

Methods: At enrollment, active sJIA patients (2-<20 years) started open-label canakinumab (4mg/kg every 4 weeks [q4w] subcutaneously). Efficacy measures included the adapted JIA American College of Rheumatology (aJIA-ACR) criteria, Juvenile Arthritis Disease Activity Score (JADAS), and clinically inactive disease (CID)/clinical remission on medication (CR), evaluated by either JADAS (CID /CR ) or ACR criteria (CID /CR ). Read More

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http://dx.doi.org/10.1002/art.41436DOI Listing

Parenting problems postpartum can be detected early in pregnancy in patients with rheumatoid arthritis.

RMD Open 2020 07;6(2)

Rheumatology, Erasmus MC, Rotterdam, Netherlands.

Objective: To describe parenting disability postpartum in patients with rheumatoid arthritis (RA) using the Parenting Disability Index and to determine early in pregnancy which patients will face parenting problems postpartum.

Methods: Data were collected from a prospective study on pregnancy and RA (Pregnancy induced Amelioration of Rheumatoid Arthritis study). Postpartum visits were performed at 6, 12 and 26 weeks after delivery. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001276DOI Listing

Trends of lymphoma incidence in US veterans with rheumatoid arthritis, 2002-2017.

RMD Open 2020 07;6(2)

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Objective: Past epidemiological studies have consistently demonstrated a link between rheumatoid arthritis (RA) and the incidence of lymphoma and it has been posited that high systemic inflammatory activity is a major risk determinant of lymphomagenesis. Given advances in the therapeutic armamentarium for RA management in recent years, the resulting lower level of disease activity could have led to a decline in lymphoma incidence in patients with RA. This study examined recent trends in lymphoma incidence in US veterans with RA. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001241DOI Listing

Methotrexate and rheumatoid arthritis associated interstitial lung disease.

Eur Respir J 2020 Jul 9. Epub 2020 Jul 9.

Department of Rheumatology, DMU Locomotion, INSERM UMR1152, Hôpital Bichat-Claude Bernard, APHP, Université de Paris, Paris, France

Question Addressed By The Study: Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. Read More

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http://dx.doi.org/10.1183/13993003.00337-2020DOI Listing

Delay and Diagnostic Pathway of Patients with Psoriatic Arthritis in Spain.

Reumatol Clin 2020 Jul 6. Epub 2020 Jul 6.

Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, España; Unidad de Reumatología, Hospital Universitario HLA Moncloa, Madrid, España.

Introduction And Objectives: Delayed diagnosis results in a worse prognosis in patients with psoriatic arthritis. Our objective is to determine the diagnostic delay, the specialties consulted and the referral points of patients with psoriatic arthritis in our environment.

Patients And Methods: We distributed a survey to members of the Spanish association Acción Psoriasis inquiring about the objectives of the study. Read More

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http://dx.doi.org/10.1016/j.reuma.2020.05.009DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328558PMC

Basic Immunology may lead to translational therapeutic rationale:: SARS-CoV-2 and Rheumatic Diseases.

Eur J Clin Invest 2020 Jul 9:e13342. Epub 2020 Jul 9.

Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

COVID-19 pandemia is a major concern for patients and health care systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analyzing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. Read More

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http://dx.doi.org/10.1111/eci.13342DOI Listing

Health service utilization in immigrants with multiple sclerosis.

PLoS One 2020 9;15(7):e0234876. Epub 2020 Jul 9.

ICES, Toronto, Ontario, Canada.

Background: Access to neurology specialty care can influence outcomes in individuals with multiple sclerosis (MS), but may vary based on patient sociodemographic characteristics, including immigration status.

Objective: To compare health services utilization in the year of MS diagnosis, one year before diagnosis and two years after diagnosis in immigrants versus long-term residents in Ontario, Canada.

Methods: We identified incident cases of MS among adults aged 20-65 years by applying a validated algorithm to health administrative data in Ontario, Canada, a region with universal health insurance and comprehensive coverage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234876PLOS

Pediatric Uveitis and Scleritis in a Multi-Ethnic Asian Population.

Ocul Immunol Inflamm 2020 Jul 9:1-8. Epub 2020 Jul 9.

Singapore Eye Research Institute, Singapore , Singapore.

Purpose: To describe the demographics and clinical characteristics of pediatric uveitis and scleritis at a tertiary eye care center.

Methods: Clinical records of children with either uveitis or scleritis that presented between January 1989 and January 2016 were reviewed retrospectively.

Results: Seventy-three patients were identified. Read More

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http://dx.doi.org/10.1080/09273948.2020.1766083DOI Listing

Increased primary care use for musculoskeletal symptoms, infections and comorbidities in the years before the diagnosis of inflammatory arthritis.

RMD Open 2020 07;6(2)

Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, Netherlands.

Objectives: Little is known about relevant events in the at-risk phase of rheumatoid arthritis before the development of clinically apparent inflammatory arthritis (IA). The present study assessed musculoskeletal symptoms, infections and comorbidity in future IA patients.

Methods: In a nested case-control study using electronic health records of general practitioners, the frequency and timing of 192 symptoms or diseases were evaluated before a diagnosis of IA, using the International Classification of Primary Care coding system. Read More

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http://dx.doi.org/10.1136/rmdopen-2019-001163DOI Listing

Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND).

BMJ Open 2020 Jul 7;10(7):e038430. Epub 2020 Jul 7.

Leicester Clinical Trials Unit, University of Leicester, Leicester, UK.

Introduction: The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.

Methods And Analysis: The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring 16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342821PMC

Surgical dislocation or the modified Heuter anterior approach for Pipkin I and II femoral head fracture dislocations.

J Orthop Trauma 2020 Jun 29. Epub 2020 Jun 29.

Objectives: To compare outcomes after surgical treatment of Pipkin I and II femoral head fractures treated with either a surgical dislocation (SD) or a direct anterior approach (The Modified Heuter Approach) STUDY DESIGN:: Retrospective, multi - centre SETTING:: Three Level I trauma care centres PATIENTS:: 49 patients operated for Pipkin types I or II femoral head fractures. 27 - using SD and 22 - using modified Heuter approach.

Interventions: Initial closed reduction of the joint followed by open reduction and internal fixation of the fracture/ fragment excision. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001877DOI Listing
June 2020
1.540 Impact Factor

Occupational risk in knee osteoarthritis: a systematic review and meta-analysis of observational studies.

Arthritis Care Res (Hoboken) 2020 Jul 7. Epub 2020 Jul 7.

Institute of Bone and Joint Research, Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Objectives: To assess the association between occupational exposures and knee osteoarthritis (OA).

Methods: We systematically searched for observational studies that examined the relationship between occupational exposures and, knee OA and total knee replacement (TKR). Four databases were searched until Oct 1 , 2019. Read More

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http://dx.doi.org/10.1002/acr.24333DOI Listing

The association between exposure to childhood maltreatment and the subsequent development of functional somatic and visceral pain syndromes.

EClinicalMedicine 2020 Jun 6;23:100392. Epub 2020 Jun 6.

Midlands Health Data Research UK, University of Birmingham B152TT, United Kingdom.

Background: Childhood maltreatment is a global public health issue linked to a vast mortality and morbidity burden. This study builds on current literature to explore the risk of developing central sensitivity syndromes (CSS) (consisting of somatic and visceral pain syndromes) subsequent to childhood maltreatment exposure.

Methods: A retrospective population based open cohort study using the UK primary care database, 'The Health Improvement Network,' between 1st January 1995-31st December 2018. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329705PMC

First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

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http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Spirometry Utilization Among Patients with Asthma.

J Asthma Allergy 2020 30;13:193-203. Epub 2020 Jun 30.

Department of Medicine, UMMS-Baystate, Springfield, MA, USA.

Objective: To examine predictors of spirometry use at a tertiary academic health system and association between receipt of spirometry and outcomes.

Patients And Methods: We conducted a retrospective cohort study of adult patients with an ICD-9 CM diagnostic code for asthma and a 2014 outpatient visit in either a community health center or private practice associated with a tertiary academic medical center. The main outcome was receipt of spirometry during a 2007-2015 "exposure period. Read More

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http://dx.doi.org/10.2147/JAA.S254431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335289PMC

Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

BMJ 2020 07 7;370:m2288. Epub 2020 Jul 7.

Drug Assessment Department, Institute for Quality and Efficiency in Health Care, Im Mediapark 8, Cologne 50670, Germany

Objective: To assess the comparative effectiveness of biological medicines in rheumatoid arthritis in sufficiently similar patient populations, based on the current definitions of key outcomes.

Design: Systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

Data Sources: Clinical study reports and aggregate results from reanalyses of individual patient data on key outcomes for rheumatoid arthritis provided by study sponsors for studies conducted up to 2017, and several databases and registries from inception up to February 2017. Read More

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http://dx.doi.org/10.1136/bmj.m2288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338922PMC

Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.

J Am Geriatr Soc 2020 Jul 7;68(7):1429-1437. Epub 2020 Jul 7.

Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objectives: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). Read More

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http://dx.doi.org/10.1111/jgs.16517DOI Listing

Trends and outcomes of fungal infections in hospitalized patients of inflammatory bowel disease: a nationwide analysis.

Transl Gastroenterol Hepatol 2020 5;5:35. Epub 2020 Jul 5.

Department of Gastroenterology & Hepatology, University of Toledo Medical Center, Toledo, OH, USA.

Background: Immunosuppressive therapy is being increasingly used in the management of inflammatory bowel disease (IBD) which comprises of ulcerative colitis (UC) and Crohn's disease (CD). Patients on immunosuppressive therapy are at increased risk of developing opportunistic fungal infections. We conducted this analysis to describe the epidemiology of opportunistic fungal infections in this cohort. Read More

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http://dx.doi.org/10.21037/tgh.2019.10.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063509PMC

A systematic review and evidence synthesis of non-medical triage, self-referral and direct access services for patients with musculoskeletal pain.

PLoS One 2020 6;15(7):e0235364. Epub 2020 Jul 6.

Arthritis Research UK Primary Care Centre, School of Primary, Community & Social Care, Keele University, Keele, United Kingdom.

Introduction: The demand for musculoskeletal (MSK) care is rising, and is a growing challenge for general practice. Direct access to physiotherapy and other healthcare services may offer appropriate care for MSK pain patients but there is uncertainty regarding the effectiveness or efficiency of this approach in practice. This study aimed to review the evidence regarding characteristics, outcomes, barriers and facilitators of MSK triage and direct access services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235364PLOS
July 2020
3.234 Impact Factor

Effect of the surgical exposure on the early postoperative period after total knee arthroplasty

Orv Hetil 2020 07;161(29):1208-1214

Általános Orvostudományi Kar, Ortopédiai Klinika,Semmelweis Egyetem, Budapest, Üllői út 78/b, 1082.

Introduction: Total knee arthroplasty has become one of the most successful and safest surgical procedures in orthopedic surgery. Of the many different types of surgical exposure, the most common, so-called medial parapatellar (MP) incision is the cut of the quadriceps tendon, which impairs extensor function. In contrast, subvastus (S) exposure, which spares the extensor apparatus, may promise better healing. Read More

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http://dx.doi.org/10.1556/650.2020.31774DOI Listing

Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jul 5. Epub 2020 Jul 5.

Department of Rheumatology, the third Affiliated Hospital of SUN YAT-SEN University, Guangzhou, China.

Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA.

Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12. Read More

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http://dx.doi.org/10.1002/acr.24371DOI Listing

Do rheumatoid arthritis patients have low back pain or radiological lumbar lesions more frequently than the healthy population? -Cross-sectional analysis in a cohort study with age and sex-matched healthy volunteers.

Spine J 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background Context: Rheumatoid arthritis (RA) can affect the spine; however, the epidemiology of lumbar lesions and/or low back pain (LBP) in RA patients has not been well-studied.

Purpose: The purpose of this study was to compare the prevalence of lumbar lesions and LBP in RA patients with that in healthy volunteers, and to elucidate the influence of RA on lumbar disease.

Study Design: Cross-sectional analysis in a cohort study with age- and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.020DOI Listing

Autoantibodies to Malondialdehyde-Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies.

Arthritis Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA.

Objectives: To examine serum autoantibodies to malondialdehyde-acetaldehyde (MAA) prior to rheumatoid arthritis (RA) diagnosis.

Methods: Anti-MAA antibody isotypes, anti-CCP2, and RF-IgM were measured in pre- and post-RA diagnosis samples (n=214 cases, 210 controls). The timing of elevations in autoantibody concentrations relative to RA diagnosis was explored using separate mixed-models for each antibody and/or isotype. Read More

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http://dx.doi.org/10.1002/art.41424DOI Listing

Extensor tendon ruptures in rheumatoid wrists.

Eur J Orthop Surg Traumatol 2020 Jul 3. Epub 2020 Jul 3.

Klinik Und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie-Operative Notaufnahme, UKGM Universitätsklinikum Gießen Und Marburg, Rudolf-Buchheim-Str. 7, 35392, Giessen, Germany.

Background And Aims: Rheumatoid arthritis is a chronic inflammatory disease. The associated involvement of hands and tendons is over 90% and impairs overall function. In the course of the disease, the joints are often operated on. Read More

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http://dx.doi.org/10.1007/s00590-020-02731-1DOI Listing

Understanding factors associated with vaccine uptake and vaccine hesitancy in patients with rheumatoid arthritis: a scoping literature review.

Clin Rheumatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychology, Université du Québec à Montréal (UQAM), CP 8888, Sucursale Centre-Ville, Montréal, Quebec, H3C 3P8, Canada.

Due to higher risk of complications associated with vaccine-preventable infections (e.g., influenza, pneumococcus), patients with rheumatoid arthritis (RA) are a priority group for vaccination. Read More

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http://dx.doi.org/10.1007/s10067-020-05059-7DOI Listing

Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still's disease.

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-218032DOI Listing

Response to: 'Changing the outcome measures, changing the results? The urgent need of a specific Disease Activity Score to adult-onset Still's disease' by Ruscitti .

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2020-218143DOI Listing

Therapeutic approaches in the treatment of gout.

Semin Arthritis Rheum 2020 Jun;50(3S):S24-S30

Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH, United States.

Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1ß in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.010DOI Listing

Population-based estimates of healthy working life expectancy in England at age 50 years: analysis of data from the English Longitudinal Study of Ageing.

Lancet Public Health 2020 Jul;5(7):e395-e403

School of Primary, Community and Social Care, Keele University, Newcastle under Lyme, UK; MRC Versus Arthritis Centre for Musculoskeletal Health and Work, University of Southampton, Southampton, UK.

Background: Retirement ages are rising in many countries to offset the challenges of population ageing, but people's capacity to work for more years in their later working life (>50 years) is unclear. We aimed to estimate healthy working life expectancy in England.

Methods: This analysis included adults aged 50 years and older from six waves (2002-13) of the English Longitudinal Study of Ageing (ELSA), with linked mortality data. Read More

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http://dx.doi.org/10.1016/S2468-2667(20)30114-6DOI Listing

A Systematic Literature Review of Residual Symptoms and Unmet Need in Patients with Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK.

Objective: To evaluate the nature and burden of residual disease in rheumatoid arthritis (RA) in patients who meet treatment targets. Secondly, for those who did not meet targets, evaluate how much is due to patient symptoms.

Methods: Prospective and retrospective studies were searched in MEDLINE, Embase, and Cochrane Library in the English language from January 1, 2008, to April 18, 2018; conference abstracts (from January 2016 to April 2018) and reference lists of relevant studies were also screened. Read More

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http://dx.doi.org/10.1002/acr.24369DOI Listing

Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Background: Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimulator (BLyS), interferon-inducible protein-10 (IP-10), interferon-alpha (IFN-α)]; or negatively associated with anti-inflammatory cytokine interleukin-10 (IL-10)]; and whether associations were modified by SLE-related autoantibody status.

Methods: The Nurses' Health Study (NHS, n=121,700) and NHSII (n=116,429) cohorts were begun in 1976 and 1989. Read More

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http://dx.doi.org/10.1002/acr.24370DOI Listing