19,837 results match your criteria Arthritis And Rheumatism[Journal]


Clinical characterization, long-term follow-up, and response to treatment of patients with syndrome of undifferentiated recurrent fever (SURF).

Semin Arthritis Rheum 2022 May 10;55:152024. Epub 2022 May 10.

Centro Malattie Autoinfiammatorie e Immunodeficienze, Clinica Pediatrica - Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy. Electronic address:

Objectives: To describe a homogeneous group of patients with undifferentiated recurrent fevers followed-up in a tertiary referral center for systemic autoinflammatory diseases (SAIDs).

Methods: Patients with undifferentiated recurrent fevers seen at our Center from 2008 to 2021 and followed-up for at least one year were included in a retrospective study. Monogenic recurrent fevers, patients carrying variants of unknown origin and PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis) syndrome were excluded. Read More

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Metabolomics analysis reveals four biomarkers associated with the gouty arthritis progression in patients with sequential stages.

Semin Arthritis Rheum 2022 May 5;55:152022. Epub 2022 May 5.

National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang, 330006, China. Electronic address:

Objectives: The gouty arthritis (GA) progression was multistage, yet the GA clinical diagnosis guidelines were more inclined to suitable for acute gouty arthritis (AGA), thus neglecting of the progress of GA. This study aimed to identify specific biomarkers that were competent for reflecting the progression of GA and attempted to provide evidence for seasonable intervention of appropriate clinical treatment.

Methods: A total of 547 patients with GA at sequential stages and healthy volunteers were divided into a training set (n = 347) and a validation set (n = 200). Read More

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Pregnancy outcomes in Takayasu arteritis patients.

Semin Arthritis Rheum 2022 Apr 28;55:152016. Epub 2022 Apr 28.

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:

Objectives: To investigate the pregnancy outcomes of patients with Takayasu arteritis (TAK) and identify the relevant risk factors.

Methods: A total of 110 pregnancies in 80 patients in a Chinese TAK cohort and 550 matched pregnancies in healthy women between 2000 and 2020 were included. The pregnancy outcomes between patients and controls were compared by Fisher's exact test. Read More

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Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study.

Semin Arthritis Rheum 2022 Apr 28;55:152019. Epub 2022 Apr 28.

Division of Rheumatology Department of Internal Medicine, Seoul National University Bundang Hospital, 166 Gumiro Bundang-gu Seongnam-si Kyeongki-do, Seongnam, Korea; Division of Rheumatology Department of Internal Medicine, Seoul National University College of Medicine, Seongnam, Korea. Electronic address:

Background: To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX).

Methods: Using Korea National Health Insurance Service database, we conducted a cohort study on RA patients initiating TNFi, leflunomide, or tacrolimus. The primary outcome was any serious infections defined as a composite endpoint of serious bacterial, opportunistic, and herpes zoster infections. Read More

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Subclinical giant cell arteritis in new onset polymyalgia rheumatica A systematic review and meta-analysis of individual patient data.

Semin Arthritis Rheum 2022 Apr 28;55:152017. Epub 2022 Apr 28.

Department of Rheumatology, University Hospital Basel, Basel, Switzerland. Electronic address:

Objectives: To determine the prevalence and predictors of subclinical giant cell arteritis (GCA) in patients with newly diagnosed polymyalgia rheumatica (PMR).

Methods: PubMed, Embase, and Web of Science Core Collection were systematically searched (date of last search July 14, 2021) for any published information on any consecutively recruited cohort reporting the prevalence of GCA in steroid-naïve patients with PMR without cranial or ischemic symptoms. We combined prevalences across populations in a random-effect meta-analysis. Read More

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Corrigendum to Safety of biologic treatments in solid organ transplant recipients: A systematic review. Semin Arthritis Rheum 51(2021): 1263-1273.

Semin Arthritis Rheum 2022 May 4;55:152015. Epub 2022 May 4.

Department of Rheumatology, CHRU Besançon, France; EA 4267: "PEPITE", FHU increase, Université Bourgogne - Franche Comté, UFR SMP, Besançon-France.

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Efficacy and safety of tofacitinib versus leflunomide with glucocorticoids treatment in Takayasu arteritis: A prospective study.

Semin Arthritis Rheum 2022 Apr 29;55:152018. Epub 2022 Apr 29.

Department of Rheumatology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China. Electronic address:

To investigate the efficacy and safety of leflunomide (LEF) versus tofacitinib (TOF) in Takayasu arteritis (TAK) patients. Sixty-seven active patients were recruited from an ongoing observational TAK cohort, including 35 patients treated with glucocorticoids (GCs) and LEF and 32 patients treated with GCs and TOF. The observation period was 12 months. Read More

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An international Delphi exercise to identify items of importance for measuring response to treatment in ANCA-associated vasculitis.

Semin Arthritis Rheum 2022 Apr 28;55:152021. Epub 2022 Apr 28.

Division of Rheumatology, Department of Medicine, and Division of Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objective: ANCA-associated vasculitis (AAV) is characterized by fluctuating levels of disease activity, but no formal criteria exist to measure response to treatment. This Delphi exercise aimed to reach consensus about which measures are considered by patients and physicians to be most important when assessing response to treatment in clinical trials of AAV.

Methods: An international 3-round online Delphi exercise was conducted. Read More

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Giant cell arteritis-related stroke in a large inception cohort: A comparative study.

Semin Arthritis Rheum 2022 Apr 28;55:152020. Epub 2022 Apr 28.

Internal Medicine Department, University Hospital of Limoges, France. Electronic address:

Objective: Stroke caused by giant cell arteritis (GCA) is a rare but devastating condition and early recognition is of critical importance. The features of GCA-related stroke were compared with those of GCA without stroke and atherosclerosis-related or embolic stroke with the aim of more readily diagnosing GCA.

Methods: The study group consisted of 19 patients who experienced GCA-related strokes within an inception cohort (1982-2021) of GCA from the internal medicine department, and the control groups each consisted of 541 GCA patients without a stroke and 40 consecutive patients > 50 years of age with usual first ever stroke from the neurology department of a French university hospital. Read More

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Does smoking protect against developing osteoarthritis? Evidence from a genetically informed perspective.

Semin Arthritis Rheum 2022 Apr 21;55:152013. Epub 2022 Apr 21.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China. Electronic address:

Objective: Cumulative evidence from observational studies showed an inverse association between smoking and osteoarthritis (OA), but this association could be confounded by obesity. This study aimed to decipher the causal effect of smoking on osteoarthritis risk from a genetically informed perspective.

Methods: We performed a two-sample univariable and multivariable MR to evaluate the independent effect of smoking on OA risk. Read More

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What is peripheral spondyloarthritis? Identifying proportion, phenotype and burden in post hoc analysis of the ASAS-PerSpA study.

Semin Arthritis Rheum 2022 Apr 21;55:152012. Epub 2022 Apr 21.

Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany. Electronic address:

Background: Little is known about the prevalence, phenotype, and burden of peripheral spondyloarthritis (pSpA). The objective of the study is to compare the phenotype and burden of disease of pure pSpA to that of pure psoriatic arthritis (PsA), pure axial SpA (axSpA), and combined forms of SpA.

Methods: This is a post hoc analysis of 4,185 patients from the cross-sectional ASAS-Peripheral involvement in SpA (PerSpA) study. Read More

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Serum levels of anti-transcriptional intermediary factor 1-γ autoantibody associated with the clinical, pathological characteristics and outcomes of patients with dermatomyositis.

Semin Arthritis Rheum 2022 Apr 21;55:152011. Epub 2022 Apr 21.

Peking University China-Japan Friendship School of Clinical Medicine, 100029 Beijing, China; Department of Rheumatology, China-Japan Friendship Hospital, 100029 Beijing, China. Electronic address:

Objective: To investigate the association of the serum levels of anti-transcriptional intermediary factor 1 (TIF1)-γ autoantibodies with the clinical and pathological characteristics, as well as the prognosis of adult patients with dermatomyositis (DM).

Methods: Eighty-seven adult DM patients with anti-TIF1-γ autoantibodies positive screened by immunoblotting assay were enrolled in the study. The presence and levels of anti-TIF1-γ autoantibodies were examined through enzyme-linked immunosorbent assay (ELISA). Read More

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A letter to: A meta-analysis of clinical manifestations in Asian systemic lupus erythematous: The effects of ancestry, ethnicity and gender.

Semin Arthritis Rheum 2022 Apr 15;55:152008. Epub 2022 Apr 15.

Rheumatology and Clinical Immunology Department, University of Pittsburgh Medical Center, 3500 Terrace Street. Bioscience Tower South, 7th floor. Pittsburgh, PA 15261, United States.

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Psychological stress in rheumatoid arthritis: a systematic scoping review.

Semin Arthritis Rheum 2022 Apr 21;55:152014. Epub 2022 Apr 21.

Skeletal Biology and Engineering Research Centre, KU Leuven, Leuven, Belgium; Rheumatology, University Hospitals Leuven, Leuven, Belgium.

Background: Rheumatoid arthritis (RA) considerably impacts patients' mental health. However, it is largely unclear how people suffering from RA experience psychological stress beyond depression or anxiety, and what drives stress in these patients.

Objective: To examine the impact of RA on psychological stress, as follows: 1) How is stress defined and described in studies on RA? 2) Do patients with RA experience more stress than the general population or people suffering from other chronic conditions? 3) What are risk factors for developing stress in this context?

Methods: We systematically searched EMBASE, PubMed, Web of Science Core Collection and Cochrane Library for English language peer-reviewed reports published up to 19 April 2020. Read More

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The glucocorticoid toxicity index: Measuring change in glucocorticoid toxicity over time.

Semin Arthritis Rheum 2022 Apr 15;55:152010. Epub 2022 Apr 15.

Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.

Glucocorticoids (GCs) have been the cornerstone of treating dozens of inflammatory conditions for more than seven decades. GC toxicity is ubiquitous in both clinical trials and clinical practice, and toxicities associated with GC use are central to the experience of most patients being treated for immune-mediated conditions. These conditions span the full range of medical specialties, including rheumatology, nephrology, gastroenterology, neurology, pulmonology, ophthalmology, and others. Read More

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Effects of patient and disease characteristics on global functioning in patients with axial spondyloarthritis in routine care.

Semin Arthritis Rheum 2022 Apr 15;55:152006. Epub 2022 Apr 15.

Rheumazentrum Ruhrgebiet, Herne, Germany; Ruhr-Universität Bochum, Germany.

Background: The ASAS Health Index (ASAS HI) was developed to assess global functioning in patients with axial spondyloarthritis (axSpA). Influencing factors have not been studied to date, especially the influence of inflammation and structural changes in the spine has remained unclear to date.

Objective: To find out whether and to what degree do axial inflammation, radiographic damage and other clinical features influence global functioning of patients with axSpA. Read More

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Risk factors for the progression of rheumatoid arthritis-related interstitial lung disease: Clinical features, biomarkers, and treatment options.

Semin Arthritis Rheum 2022 Apr 11;55:152004. Epub 2022 Apr 11.

Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address:

Objectives: The clinical heterogeneity of the progression of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is high, and there is a lack of consensus on the clinical relevance and medical protocols. The purpose of this study is to explore the impact of clinical characteristics, new biomarkers and treatment options on the prognosis of RA-ILD patients and to explore whether these factors can predict the progression and death of these patients.

Methods: We retrospectively collected case data on RA-ILD patients who visited or were admitted to Changhai Hospital between October 2010 and September 2021. Read More

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Adipocytokines and achievement of low disease activity in rheumatoid arthritis.

Semin Arthritis Rheum 2022 Apr 12;55:152003. Epub 2022 Apr 12.

Medicine Service, VA Nebraska-Western Iowa Health Care System and Department of Internal Medicine, Division of Rheumatology & Immunology, University of Nebraska Medical Center, Omaha, NE, United States.

Purpose: To determine if adipocytokines are independently associated with the achievement of low disease activity (LDA) over long-term follow-up in a large rheumatoid arthritis (RA) registry.

Methods: This cohort study evaluated adults with RA from the Veteran's Affairs RA Registry. Adipocytokines (adiponectin, leptin, and fibroblast growth factor [FGF]-21) and inflammatory cytokines were measured as part of a multi-analyte panel on banked serum from enrollment. Read More

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Diagnosis for early stage knee osteoarthritis: probability stratification, internal and external validation; data from the CHECK and OAI cohorts.

Semin Arthritis Rheum 2022 Apr 15;55:152007. Epub 2022 Apr 15.

Department of General Practice, Erasmus MC University Center Rotterdam, Rotterdam, the Netherlands; Department of Orthopaedics & Sports Medicine, Erasmus MC University Center Rotterdam, Rotterdam, the Netherlands.

Objective: To internally and externally validate our diagnostic criteria of early stage knee osteoarthritis (OA) in the CHECK and OAI cohorts.

Design: We applied two previously developed diagnostic models to all knees in CHECK and OAI cohorts to calculate probabilities of early stage knee OA at baseline. Knees were categorized into three groups based on probability: 'no OA' (probability ≤ 30%), 'uncertain' (probability between 30% and 70%) and 'early stage OA' (probability ≥ 70%). Read More

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Reply on: a meta-analysis of clinical manifestations in asian systemic lupus erythematous: The effects of ancestry, ethnicity and gender.

Semin Arthritis Rheum 2022 Apr 15;55:152009. Epub 2022 Apr 15.

Division of Rheumatology, Department of Medicine, National University Hospital, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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Myositis-specific autoantibodies in clinical practice: Improving the performance of the immunodot.

Semin Arthritis Rheum 2022 Mar 29;55:151998. Epub 2022 Mar 29.

Immunology laboratory, Institut Fédératif de Biologie, Toulouse University Hospital Center, France; Center for Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR 5282, Toulouse III University, Toulouse, France.

Background/objectives: Idiopathic inflammatory myopathies (IIM) diagnosis and sub-classification can be improved by detection of myositis specific antibodies (MSA) as a first step in diagnosis. However, when using semi-quantitative immunodots for MSA detection, clinical assay performance needs to be improved.

Methods: A retrospective study was done for the "myositis" and "synthetase" immunodots (SRP, NXP2, TIF1gamma, SAE1/2, Mi2, MDA5, Jo1, PL7, PL12, EJ, OJ, KS, ZO and HA) from D-Tek used for 270 patients who had tested positive for MSA in a tertiary laboratory hospital. Read More

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Reply to letters to the Editor re: Low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort.

Semin Arthritis Rheum 2022 Jun 26;54:151999. Epub 2022 Mar 26.

Arthritis Section, VA Puget Sound Health Care System, 1660 South Columbian Way, S-151-A, Seattle, WA 98108, USA; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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Outcome measures in rheumatology applied in self-management interventions targeting people with inflammatory Arthritis A systematic review of outcome domains and measurement instruments.

Semin Arthritis Rheum 2022 Jun 16;54:151995. Epub 2022 Mar 16.

Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Valdemar Hansens vej 1-13, 2600 Glostrup, Denmark. Electronic address:

Objective: Evaluating the effect of self-management interventions targeting people with inflammatory arthritis (IA) is a challenge because self-management interventions are complex and consensus on important outcomes is lacking. The aim is to identify, and map applied outcome domains and outcome measurement instruments from previous trials measuring the effect of self-management interventions targeting people with IA.

Method: We performed an informative systematic literature review following guidance from the 'Outcome Measures in Rheumatology' (OMERACT) and 'Core Outcome Measures in Effectiveness Trials' (COMET) initiatives. Read More

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Development and testing of the rheumatoid arthritis quality of care survey.

Semin Arthritis Rheum 2022 Jun 26;54:152002. Epub 2022 Mar 26.

Department of Medicine, Cumming School of Medicine, University of Calgary, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Arthritis Research Canada, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Canada. Electronic address:

Objectives: The Rheumatoid Arthritis (RA) Quality of Care Survey (RAQCS) was developed to measure care quality according to a previously developed national RA quality improvement framework.

Methods: The development of the RAQCS occurred over 3 phases. First, the survey was developed by a team of healthcare providers, researchers, and two patient partners based on the existing national quality framework's 21 performance measures (PMs) and strategic objectives. Read More

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Associations between mean simplified disease activity index score and bone mineral density of patient with rheumatoid arthritis in Asian cohort.

Semin Arthritis Rheum 2022 Jun 26;54:152001. Epub 2022 Mar 26.

Department of Rheumatology, Kochi Memorial Hospital, Kochi, Kochi Prefecture, Japan. Electronic address:

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Correspondence on "low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort" by Wysham et al.

Authors:
Amy Ker Pei-En Kao

Semin Arthritis Rheum 2022 Jun 24;54:152000. Epub 2022 Mar 24.

School of Medicine, Chung Shan Medical University, Rm. 201, 2F., No. 522, Fuxing N. Rd., South District., Taichung City 402028, Taiwan. Electronic address:

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What to expect when women with axial spondyloarthritis are expecting: Prevalence of complications of pregnancies in women with axial spondyloarthritis.

Semin Arthritis Rheum 2022 Jun 10;54:151993. Epub 2022 Mar 10.

Department of Rheumatology, St James' Hospital, James Street, Dublin, Ireland; School of Medicine, Trinity College Dublin, College Green, Dublin, Ireland.

Background: Understanding of axSpA is evolving rapidly. Unfortunately, for women with axSpA there is limited data available on pregnancy complications. The Ankylosing Spondylitis Registry of Ireland (ASRI) is a source of epidemiological data on axSpA in Ireland. Read More

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Impact of biologics on health-related quality of life in patients with Ankylosing spondylitis: A systematic review and meta-analysis of randomized controlled trials.

Semin Arthritis Rheum 2022 Jun 19;54:151996. Epub 2022 Mar 19.

College of Pharmacy, Western University of Health Sciences, 309 E. Second St., Pomona, CA 91766, United States. Electronic address:

Objective: To examine the impact of novel biologic disease-modifying antirheumatic drugs (bDMARDs) with tumor necrosis factor (TNF) inhibitors or Interleukin-17A (IL-17A) antibody agents on health-related quality of life (HRQoL) outcomes in patients with radiographic axial spondyloarthritis (r-axSpA).

Methods: A literature search on PubMed, Embase, and Clinicaltrials.gov databases was performed through February 2022 to identify randomized controlled trials (RCTs) reporting HRQoL outcomes of bDMARDs for treatment of r-axSpA. Read More

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Correspondence to "The incidence and risk factors for venous thromboembolic events in patients with psoriasis and psoriatic arthritis".

Semin Arthritis Rheum 2022 Feb 22;55:151982. Epub 2022 Feb 22.

Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City 40201, Taiwan. Electronic address:

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February 2022