318,270 results match your criteria Arthritis & rheumatology Hoboken N.J.[Journal]


Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

J Ethnopharmacol 2019 Apr 21:111902. Epub 2019 Apr 21.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China. Electronic address:

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by failure of spontaneous resolution of inflammation. The stem of Kadsura heteroclite (KHS) is a well-known anti-arthritic Tujia ethnomedicinal plant, which named Xuetong in folk, has long been used for the prevention and treatment of rheumatic and arthritic diseases.

Aim Of The Study: The analgesic and anti-inflammatory effects and the potential mechanisms behind such effects of KHS would be investigated by using different animal models. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111902DOI Listing

Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.

Ann Noninvasive Electrocardiol 2019 Apr 24:e12651. Epub 2019 Apr 24.

Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.

Background: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown.

Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders.

Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. Read More

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http://dx.doi.org/10.1111/anec.12651DOI Listing

The development of inflammatory arthritis and enthesitis in patients on dupilumab: a case series.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

St. John's Institute of Dermatology, Guy's and St, Thomas' Hospital NHS Trust, Great Maze Pond, London, SE1 9RT.

Dupilumab (Dupixent , Sanofi), a fully human monoclonal antibody that blocks interleukin (IL)-4 and IL-13 signaling, is the first biologic approved in the UK for adult patients with moderate-to-severe atopic dermatitis (AD). In phase III studies, dupilumab was an effective treatment with 44-51% of patients achieving at least 75% improvement in Eczema Area and Severity Index (EASI). To date, dupilumab has been well tolerated; common adverse reactions reported from phase III data include injection-site reactions (8-19%), allergic conjunctivitis (3-19%) and oral herpes (2-5%). Read More

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http://dx.doi.org/10.1111/bjd.18031DOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

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http://dx.doi.org/10.1177/0954411919845747DOI Listing

Successful Treatment of Refractory Plaque-Type Psoriasis and Psoriatic Arthritis With Guselkumab and Adalimumab Combination Therapy: A Case Report

J Drugs Dermatol 2019 Apr;18(4):394-396

Copy: A number of biologics have been approved for use in plaque-type psoriasis. They act by either blocking the action of a specific type of cell or protein in the immune system. Case presentation: Herein, we report a case of a 46-year-old woman with a 12-year history of severe plaque psoriasis and psoriatic arthritis who was treated successfully with guselkumab and adalimumab after failure of prior topical corticosteroids, cyclosporine and narrow-band ultraviolet B (NBUVB) phototherapy. Read More

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Capillaroscopic features of microangiopathy in rheumatoid arthritis patients with peripheral vascular syndrome.

Clin Rheumatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1007/s10067-019-04561-xDOI Listing

Rituximab in connective tissue disease-associated interstitial lung disease.

Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

Rheumatology Department, Hospital Garcia de Orta EPE, Avenida Torrado da Silva, 2805-267, Almada, Portugal.

Introduction/objectives: To evaluate rituximab (RTX) effectiveness and safety in patients with interstitial lung disease (ILD) related to connective tissue diseases (CTD).

Methods: Retrospective multicenter cohort study, including patients with CTD-ILD, followed in six Portuguese rheumatology departments until November 2018. ILD diagnosis was based on high-resolution CT (HRCT) and/or lung biopsy. Read More

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http://link.springer.com/10.1007/s10067-019-04557-7
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http://dx.doi.org/10.1007/s10067-019-04557-7DOI Listing
April 2019
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Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR.

Clin Rheumatol 2019 Apr 17. Epub 2019 Apr 17.

Santiago University Clinical Hospital Institute of Medical Research, Santiago de Compostela, Spain.

Objective: Most reports on serious infections (SI) in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) are from the USA and Western Europe. Data from other regions are largely missing. We report data from South American countries with different backgrounds and health-care systems but similar registries. Read More

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http://dx.doi.org/10.1007/s10067-019-04516-2DOI Listing

Dopaminergic Agents in Rheumatoid Arthritis.

Authors:
Silvia Capellino

J Neuroimmune Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Junior Group Neuroimmunology, Department of Immunology, IfADo - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

Clinical evidences suggest a causal relationship between rheumatoid arthritis (RA) and the dopaminergic system, and several studies described an alteration of the disease in patients treated with dopaminergic agents. Despite these interesting results, potential direct effects of dopamine on RA have not been intensively considered until the last decade. Recent studies confirm a direct effect of dopamine on the systemic immune response as well as on bone remodeling and on joint inflammation, both in humans and in different animal models of arthritis. Read More

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http://dx.doi.org/10.1007/s11481-019-09850-5DOI Listing

Effectiveness of Remission Induction Strategies for Early Rheumatoid Arthritis: a Systematic Literature Review.

Curr Rheumatol Rep 2019 Apr 23;21(6):24. Epub 2019 Apr 23.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, G02.228, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.

Purpose Of Review: To review the effectiveness of remission induction strategies compared to single csDMARD-initiating strategies according to current guidelines in early RA.

Recent Findings: Twenty-nine studies, heterogeneous on, e.g. Read More

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http://dx.doi.org/10.1007/s11926-019-0821-1DOI Listing

[Depressive symptoms in early rheumatoid arthritis : Within the rheumatism network ADAPTHERA].

Z Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

ACURA Rheumazentrum Rheinland-Pfalz, Kaiser-Wilhelm-Straße 9-11, 55543, Bad Kreuznach, Deutschland.

Background And Objective: For patients with established rheumatoid arthritis and also early arthritis an increased prevalence of depression has been described. For a better understanding of depression in early arthritis patients, depression prevalences of a German early arthritis cohort were examined, with a focus on disease activity, anti-CCP status, disease duration and functional capacity over a period of 2 years.

Material And Methods: The evaluation was based on the early arthritis cohort ADAPTHERA from Rhineland-Palatinate. Read More

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http://dx.doi.org/10.1007/s00393-019-0596-9DOI Listing

Anatomic Reinforced Medial Meniscal Root Reconstruction With Gracilis Autograft.

Arthrosc Tech 2019 Mar 5;8(3):e209-e213. Epub 2019 Feb 5.

Palmetto-Health USC Orthopaedics, Columbia, South Carolina, U.S.A.

Meniscal root tears, left untreated, result in accelerated progression of arthritis. Numerous techniques to repair medial meniscus posterior root tears have been presented in the literature. Direct repair of the meniscus to bone without reconstructive tissue may result in a nonanatomic and biologically weak construct with a significant number of structural repair failures. Read More

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http://dx.doi.org/10.1016/j.eats.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470346PMC

Comparative Evaluation of Ga-Citrate PET/CT and F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats.

Contrast Media Mol Imaging 2019 19;2019:2353658. Epub 2019 Mar 19.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. Read More

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http://dx.doi.org/10.1155/2019/2353658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231PMC

Measurement of Disease Activity in Ecuadorian Patients with Rheumatoid Arthritis: Does RAPID3 Correlate with Traditional Indexes?

ScientificWorldJournal 2019 20;2019:6940401. Epub 2019 Mar 20.

Department of Rheumatology, Unidad de Enfermedades Reumáticas y Autoinmunes [UNERA] (Unit of Rheumatology and Autoimmune Diseases), Guayaquil, Ecuador.

Objective: The aim of this study is to demonstrate if routine assessment of patient index data 3 has a correlation with disease's activity as much as disease activity score 28, clinical disease activity index, and simplified disease activity index in Ecuadorian patients with rheumatoid arthritis seen in Unidad de Enfermedades Reumáticas y Autoinmunes [UNERA] from December 2016 to December 2017.

Methods: This is a retrospective study in 200 patients that fulfill the American College of Rheumatology 2010 criteria for diagnosis of rheumatoid arthritis. The patients were evaluated from December 2016 to December 2017. Read More

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http://dx.doi.org/10.1155/2019/6940401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446084PMC

Hes1 attenuates type I IFN responses via VEGF-C and WDFY1.

J Exp Med 2019 Apr 23. Epub 2019 Apr 23.

Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China

Induction of type I interferons (IFNs) is critical for eliciting competent immune responses, especially antiviral immunity. However, uncontrolled IFN production contributes to pathogenesis of autoimmune and inflammatory diseases. We found that transcription factor Hes1 suppressed production of type I IFNs and expression of IFN-stimulated genes. Read More

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http://dx.doi.org/10.1084/jem.20180861DOI Listing

Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy.

J Control Release 2019 Apr 20. Epub 2019 Apr 20.

Department of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Owing to its intricate autoimmune pathophysiology and significant risks of progression to other rheumatic co-morbidities (i.e., osteoporosis and osteoarthritis), a plausible therapeutic regimen is mandatory for early-stage management of rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.027DOI Listing

Psoriatic arthritis for dermatologists.

J Dermatolog Treat 2019 Apr 24:1-63. Epub 2019 Apr 24.

b Department of Medicine, Division of Rheumatology and Department of Dermatology , Brigham and Women's Hospital, Harvard Medical School , Boston , MA.

Psoriatic arthritis (PsA) affects up to one-third of patients with psoriasis and is the major comorbidity of psoriasis because of the likelihood that loss of function and permanent disability will develop if initiation of treatment is delayed. Dermatologists are uniquely positioned to recognize early signs of PsA and be the first-line healthcare practitioners to detect PsA in patients with psoriasis. PsA can affect 6 clinical domains: peripheral arthritis, dactylitis, enthesitis, psoriasis, psoriatic nail disease, and axial disease. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605142DOI Listing

Recommended Reading from the Massachusetts General Hospital/ Beth Israel Deaconess Medical Center/ Harvard Pulmonary and Critical Care Medicine Fellows.

Am J Respir Crit Care Med 2019 Apr 23. Epub 2019 Apr 23.

Beth Israel Deaconess Medical Center, 1859, Pulmonary and Critical Care Medicine, Boston, Massachusetts, United States ;

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http://dx.doi.org/10.1164/rccm.201902-0471RRDOI Listing

Rheumatic complications in cancer patients treated with immune checkpoint inhibitors.

Korean J Intern Med 2019 Apr 25. Epub 2019 Apr 25.

Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-inflammatory actions. These adverse events can affect any organ system, including the endocrine, neurologic, gastrointestinal, cardiac, skin, pulmonary, and musculoskeletal systems. Read More

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http://dx.doi.org/10.3904/kjim.2019.060DOI Listing

Isolation and Characterisation of Major and Minor Collagens from Hyaline Cartilage of Hoki ().

Mar Drugs 2019 Apr 12;17(4). Epub 2019 Apr 12.

Seafood Research Unit, The New Zealand Institute for Plant and Food Research Limited, PO Box 5114, Port Nelson 7043, New Zealand.

The composition and properties of collagen in teleost (bony fish) cartilage have never been studied. In this study, we aimed to identify and characterise all collagen species in the nasal cartilage of hoki (). Four native collagen species were extracted using two techniques, and isolated with differential salt precipitation. Read More

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http://dx.doi.org/10.3390/md17040223DOI Listing

Could Polyphenols Help in the Control of Rheumatoid Arthritis?

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

College of Korean Medicine, Kyung Hee University, Seoul, Seoul 02453, Korea.

Rheumatoid arthritis (RA) is a chronic, systemic, joint-invading, autoimmune inflammatory disease, which causes joint cartilage breakdown and bone damage, resulting in functional impairment and deformation of the joints. The percentage of RA patients has been rising and RA represents a substantial burden for patients around the world. Despite the development of many RA therapies, because of the side effects and low effectiveness of conventional drugs, patients still need and researchers are seeking new therapeutic alternatives. Read More

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http://dx.doi.org/10.3390/molecules24081589DOI Listing

Memory and Learning Complaints in Relation to Depression among Elderly People with Multimorbidity.

Geriatrics (Basel) 2017 May 9;2(2). Epub 2017 May 9.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Although current models of care are generally well-suited to providing treatment for individual medical conditions, the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers, particularly in developing countries. The challenges of tackling multimorbidity are further compounded when the multimorbidity co-occurs with psychiatric conditions such as cognitive and depressive disorders. Understanding the relationships between multimorbidity and psychiatric illnesses is therefore of considerable clinical importance. Read More

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http://dx.doi.org/10.3390/geriatrics2020015DOI Listing

Muscle Strength and Functional Ability in Recreational Female Golfers and Less Active Non-Golfers over the Age of 80 Years.

Geriatrics (Basel) 2017 Mar 4;2(1). Epub 2017 Mar 4.

Faculty of Health Sciences, Building 45, University of Southampton, Southampton SO17 1BJ, UK.

Muscle strength and functional ability decline with age. Physical activity can slow the decline but whether recreational golf is associated with slower decline is unknown. This cross-sectional, observational study aimed to examine the feasibility of testing muscle strength and functional ability in older female golfers and non-golfers in community settings. Read More

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http://dx.doi.org/10.3390/geriatrics2010012DOI Listing

Anterior Thigh Tissue Thickness Measured Using Ultrasound Imaging in Older Recreational Female Golfers and Sedentary Controls.

Geriatrics (Basel) 2017 Feb 7;2(1). Epub 2017 Feb 7.

Faculty of Health Sciences, Building 45, University of Southampton, Southampton SO17 1BJ, UK.

Physical activity is vital for the prevention of sarcopenia and frailty. The training effects of recreational golf on muscle function in older people are unknown. The present study examined quadriceps muscle and subcutaneous fat thickness in 66 older females. Read More

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http://dx.doi.org/10.3390/geriatrics2010010DOI Listing
February 2017

Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently RIP1 kinase inhibitors have advanced into early clinical trials for evaluation in inflammatory diseases such as psoriasis, rheumatoid arthritis and ulcerative colitis, and neuro-logical diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. In this paper we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00318DOI Listing

Semaphorin4A coordinately induces inflammation and fibrosis in systemic sclerosis.

Arthritis Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht.

Objective: To analyze the potential role of Sema4A in inflammatory and fibrotic processes involved in the pathology of systemic sclerosis (SSc).

Methods: Sema4A levels in the plasma of healthy controls (HC, n=10) and systemic sclerosis patients (n=21) were determined by ELISA. The expression of Sema4A and its receptors in monocytes and CD4 T cells from HC and SSc patients (n=6-7, for both) was determined by ELISA and flow cytometry. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40915
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http://dx.doi.org/10.1002/art.40915DOI Listing
April 2019
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Acupressure treatment for methotrexate-induced nausea in arthritis patients.

Authors:
A Lind T Weitoft

Scand J Rheumatol 2019 Apr 23:1-2. Epub 2019 Apr 23.

a Center for Research and Development , Uppsala University/Region Gävleborg , Gävle , Sweden.

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http://dx.doi.org/10.1080/03009742.2019.1579860DOI Listing

Serum drug concentrations to optimize switching from adalimumab to etanercept in rheumatoid arthritis.

Scand J Rheumatol 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Rheumatology , Amsterdam Rheumatology and Immunology Center , Reade , Amsterdam , The Netherlands.

Objectives: Inadequate response to adalimumab can be caused by insufficient blockade of the target tumour necrosis factor (TNF) at low serum concentrations. In such cases, patients may respond to another TNF inhibitor. We investigated whether the serum adalimumab concentration is related to the efficacy of a second TNF inhibitor, etanercept, in rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1080/03009742.2019.1577915DOI Listing

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

Activation of Mast Cells Mediates Inflammatory Response in Psoriasis: Potential New Therapeutic Approach with IL-37.

Dermatol Ther 2019 Apr 22:e12943. Epub 2019 Apr 22.

Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.

Psoriasis (PS) is an autoimmune disorder characterized by chronic inflammatory skin immune-mediated disease which occurs in 2-4% of the worldwide population. PS is associated with an increased risk of cardiovascular disease and depression, and 30% of PS patients are affected with psoriatic arthritis. PS presents excessive keratinocyte proliferation, abnormal differentiation, and elevated mast cell (MC) number. Read More

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http://dx.doi.org/10.1111/dth.12943DOI Listing

RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll-like receptor signaling pathway.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.

Emerging evidence shows that rheumatoid arthritis (RA) progression can be induced by the activation of Toll-like receptor (TLR) signaling pathway. Regulator of G-protein signaling 1 (RGS1) is observed to be a candidate biomarker for arthritis. Accordingly, the present study aims to determine the potential effects of RGS1 mediating TLR on RA. Read More

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http://dx.doi.org/10.1002/jcp.28645DOI Listing

Correction to: Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn's Disease: An Integrated Analysis of Phase II/III Clinical Development Programs.

Drug Saf 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology, University of Connecticut Health Center, 21 South Road, 2nd Floor, Farmington, CT, 06030, USA.

In the original publication of this article, the following correction should be noted in Table 5. Read More

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http://dx.doi.org/10.1007/s40264-019-00816-3DOI Listing

CCL5 and related genes might be the potential diagnostic biomarkers for the therapeutic strategies of rheumatoid arthritis.

Clin Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

The Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Objective: Rheumatoid arthritis (RA) is a common disease of rheumatic diseases. The aim of this study was to identify gene signatures in RA and uncover their potential mechanisms.

Method: Gene expression profiles of GSE1919, GSE55235, GSE55457, and GSE77928 were downloaded from GEO database. Read More

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http://link.springer.com/10.1007/s10067-019-04533-1
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http://dx.doi.org/10.1007/s10067-019-04533-1DOI Listing
April 2019
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Long-term persistence in patients with osteoporosis receiving denosumab in routine practice: 36-month non-interventional, observational study.

Osteoporos Int 2019 Apr 22. Epub 2019 Apr 22.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Persistence rates over 36 months with denosumab in patients diagnosed with osteoporosis in a real-world setting were examined, along with baseline patient characteristics predictive of persistence. This study represents the longest observational period with denosumab persistence and shows higher persistence rates when compared to bisphosphonates.

Introduction: The study objective was to describe long-term persistence with denosumab among patients treated for osteoporosis in a real-world setting. Read More

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http://link.springer.com/10.1007/s00198-019-04963-2
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http://dx.doi.org/10.1007/s00198-019-04963-2DOI Listing
April 2019
2 Reads

Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development.

Biomed Res Int 2019 18;2019:8326246. Epub 2019 Mar 18.

Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan.

Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)D ultimately disease onset. Read More

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https://www.hindawi.com/journals/bmri/2019/8326246/
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http://dx.doi.org/10.1155/2019/8326246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442488PMC
March 2019
1 Read

Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases.

Case Rep Dermatol 2019 Jan-Apr;11(1):64-70. Epub 2019 Mar 19.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. Read More

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http://dx.doi.org/10.1159/000498881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465707PMC

Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.

Sci Rep 2019 Apr 23;9(1):6374. Epub 2019 Apr 23.

Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan.

Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo-5-oxo-L-norleucine (DON) and mTOR with rapamycin affects immune cells and the arthritis in a mouse model. Read More

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http://www.nature.com/articles/s41598-019-42932-1
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http://dx.doi.org/10.1038/s41598-019-42932-1DOI Listing
April 2019
1 Read

GC B cells 'AKT' to blunt BCR signaling.

Authors:
Julie Zikherman

Nat Immunol 2019 Apr 22. Epub 2019 Apr 22.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41590-019-0384-3DOI Listing
April 2019
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Economic Potential for Distributed Manufacturing of Adaptive Aids for Arthritis Patients in the U.S.

Geriatrics (Basel) 2018 Dec 6;3(4). Epub 2018 Dec 6.

Department of Materials Science & Engineering, Michigan Technological University, Houghton, MI 49931, USA.

By 2040, more than a quarter of the U.S. population will have diagnosed arthritic conditions. Read More

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http://dx.doi.org/10.3390/geriatrics3040089DOI Listing
December 2018

Subtalar Joint Distraction Arthrodesis Utilizing a Titanium Truss: A Case Series.

J Foot Ankle Surg 2019 Apr 19. Epub 2019 Apr 19.

Faculty, Division of Foot and Ankle Surgery, Western Pennsylvania Hospital, Allegheny Health Network, Pittsburgh, PA. Electronic address:

Subtalar joint distraction arthrodesis has been recommended for the treatment of conditions such as nonunion or malunion of subtalar joint arthrodesis posttraumatic arthritis. Both conditions are difficult to treat, because the deformities created in the frontal and sagittal planes of these conditions are complex. If these malalignments are not addressed, ankle joint instability and wear occur over time. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.11.022DOI Listing

Relationship Between Body Mass Index and Complications in Total Ankle Arthroplasty: A Single Surgeon's Experience in Ninety-Seven Replacements.

J Foot Ankle Surg 2019 Apr 19. Epub 2019 Apr 19.

Surgeon, Oregon Medical Group, Eugene, OR.

The purpose of this study was to compare complication rates of total ankle replacement in 2 groups of patients based on their body mass index (BMI). The total cohort was divided into 2 groups based on BMI. Group 1 included patients with a BMI ≤30 kg/m. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.11.015DOI Listing

Leap Motion Controller-based training for upper extremity rehabilitation in children and adolescents with physical disabilities: A randomized controlled trial.

J Hand Ther 2019 Apr 19. Epub 2019 Apr 19.

Medical Faculty of Cerrahpasa, Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Bakirkoy, Istanbul, Turkey.

Study Design: Randomized controlled trial.

Introduction: Juvenile idiopathic arthritis (JIA), cerebral palsy (CP), and brachial plexus birth injury (BPBI) are the most common disorders that cause upper extremity impairments in children and adolescents. Leap Motion Controller-based training (LMCBT) is a novel therapeutic method for upper extremity rehabilitation. Read More

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http://dx.doi.org/10.1016/j.jht.2019.03.012DOI Listing

Age- and gender-stratified adult myometric reference values of isometric intrinsic hand strength.

J Hand Ther 2019 Apr 19. Epub 2019 Apr 19.

Madison Metropolitan School District, Madison, WI, USA.

Study Design: Descriptive normative.

Introduction: Intrinsic hand strength can be impacted by hand arthritis, peripheral nerve injuries, and spinal cord injuries. Grip dynamometry does not isolate intrinsic strength, and manual muscle testing is not sensitive to change in grades 4 and 5. Read More

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http://dx.doi.org/10.1016/j.jht.2019.03.005DOI Listing

Research Techniques Made Simple: Mouse Models of Atopic Dermatitis.

J Invest Dermatol 2019 May 19;139(5):984-990.e1. Epub 2019 Apr 19.

Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have been heavily used to deepen our understanding of complicated disease mechanisms in AD and to provide a preclinical platform before performing clinical interventional research on novel therapeutic agents in humans. However, what aspects of human AD these mouse AD models faithfully recapitulate is insufficiently understood. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.014DOI Listing

Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1628-1634

a Department of Rheumatology , Dongfang Hospital of Beijing University of Chinese Medicine , Beijing , China.

Chronic inflammation in fibroblast-like synoviocytes (FLSs) induced by pro-inflammatory cytokines such as TNF-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). The neurokinin-1 receptor (NK-1R) is one of the G protein-coupled receptors (GPCRs) mediating the intracellular signalling of substance P (SP). However, the possible implications of NK-1R in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and the pathogenesis of RA have not yet been reported. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573177DOI Listing
December 2019

Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma.

Mar Drugs 2019 Apr 19;17(4). Epub 2019 Apr 19.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Platelet-rich plasma (PRP) is rich in growth factors and has commonly been utilized in the repair and regeneration of damaged articular cartilage. However, the major drawbacks of direct PRP injection are unstable biological fixation and fast or burst release of growth factors. Fucoidan is a heparinoid compound that can bind growth factors to control their release rate. Read More

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http://dx.doi.org/10.3390/md17040236DOI Listing

The Antioxidant from Ethanolic Extract of Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.

Tratt is a Chinese herbal remedy that is used in the treatment of diarrhea, burns, rheumatoid arthritis, and hemorrhage. Despite its use in Asian folk medicine, there are limited reports on the biological activity of fruits. This study focused on the investigation of the antitumor effect of the antioxidative ethanolic extract of fruits (RCE) along with its underlying mechanism of action. Read More

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http://dx.doi.org/10.3390/ijms20081935DOI Listing

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Eur Stroke J 2017 Sep 21;2(3):250-256. Epub 2017 Apr 21.

Division of Epidemiology & Public Health, University of Nottingham, Nottingham, UK.

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women of childbearing age in Sweden.

Patients And Methods: All women aged 15-49 years with live births/stillbirths in 1992-2011 were identified from the Swedish Medical Birth Registry linked with the National Patient Registry. First stroke during the study period was identified. Read More

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http://dx.doi.org/10.1177/2396987317706600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454822PMC
September 2017