336,722 results match your criteria Arthritis & rheumatology Hoboken N.J.[Journal]


Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jul 5. Epub 2020 Jul 5.

Department of Rheumatology, the third Affiliated Hospital of SUN YAT-SEN University, Guangzhou, China.

Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA.

Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12. Read More

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http://dx.doi.org/10.1002/acr.24371DOI Listing

A case of cryopyrin-associated periodic fever syndrome during canakinumab administration complicated by inflammatory bowel disease.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Kagoshima University Hospital, 35-1 Sakuragaoka Kagoshimashi, Kagoshima, 890-8520, Japan.

Cryopyrin-associated periodic fever syndrome (CAPS) is a highly debilitating disorder, which is characterized by unregulated interleukin-1β production driven by autosomal dominantly inherited mutations in the NLRP3 gene. Patients with CAPS often present with early-onset episodes of fever and rash. These patients also present with variable systemic signs and symptoms, such as arthritis, sensorineural hearing loss, chronic aseptic meningitis, and skeletal abnormalities, but minimal gastrointestinal symptoms. Read More

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http://dx.doi.org/10.1007/s10067-020-05267-1DOI Listing

Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Harvard Medical School, Boston, MA, USA.

Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory conditions, towards the development of cardiovascular disease has garnered considerable interest. Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease, but risk of cardiovascular disease amongst patients with cutaneous lupus is less well known. Read More

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http://dx.doi.org/10.1007/s10067-020-05257-3DOI Listing

Intra-articular injection of etanercept versus glucocorticoids in rheumatoid arthritis patients.

Clin Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Physical Medicine, Rheumatology, and Rehabilitation Department, Faculty of Medicine, Tanta University, Geish Street, Tanta, Gharbia, Egypt.

Objectives: This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients.

Methods: Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-articular injection of either etanercept or corticosteroid guided by musculoskeletal ultrasound. All patients were assessed for disease activity by disease activity score (DAS28), functional assessment using the Modified Health Assessment Questionnaire (MHAQ), and laboratory investigations (erythrocyte sedimentation rate and C-reactive protein). Read More

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http://dx.doi.org/10.1007/s10067-020-05235-9DOI Listing

Atlanto-axial rotary instability (Fielding type 1): characteristic clinical and radiological findings, and treatment outcomes following alignment, fusion, and stabilization.

Neurosurg Rev 2020 Jul 4. Epub 2020 Jul 4.

Medical and Molecular Genetics, Indiana University Health Physicians, Indianapolis, IN, USA.

Atlanto-axial instability (AAI) is common in the connective tissue disorders, such as rheumatoid arthritis, and increasingly recognized in the heritable disorders of Stickler, Loeys-Dietz, Marfan, Morquio, and Ehlers-Danlos (EDS) syndromes, where it typically presents as a rotary subluxation due to incompetence of the alar ligament. This retrospective, IRB-approved study examines 20 subjects with Fielding type 1 rotary subluxation, characterized by anterior subluxation of the facet on one side, with a normal atlanto-dental interval. Subjects diagnosed with a heritable connective tissue disorder, and AAI had failed non-operative treatment and presented with severe headache, neck pain, and characteristic neurological findings. Read More

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http://dx.doi.org/10.1007/s10143-020-01345-9DOI Listing

Obesity, but Not Metabolic Diseases, Is Associated with Risk of Psoriasis: A Population-Based Cohort Study in Taiwan.

Dermatology 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan,

Background: Obesity and metabolic diseases including diabetes, hyperlipidemia, and hypertension are reportedly associated with an increased risk of psoriasis. However, few prospective studies have investigated the association of obesity and metabolic diseases with the risk of psoriasis.

Objective: To examine whether obesity or metabolic diseases increase the risk of psoriasis. Read More

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http://dx.doi.org/10.1159/000508303DOI Listing

Do rheumatoid arthritis patients have low back pain or radiological lumbar lesions more frequently than the healthy population? -Cross-sectional analysis in a cohort study with age and sex-matched healthy volunteers.

Spine J 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background Context: Rheumatoid arthritis (RA) can affect the spine; however, the epidemiology of lumbar lesions and/or low back pain (LBP) in RA patients has not been well-studied.

Purpose: The purpose of this study was to compare the prevalence of lumbar lesions and LBP in RA patients with that in healthy volunteers, and to elucidate the influence of RA on lumbar disease.

Study Design: Cross-sectional analysis in a cohort study with age- and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.020DOI Listing

Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.

Microvasc Res 2020 Jul 2:104038. Epub 2020 Jul 2.

Departiment of Biomedical Sciences, University of Sassari, Sassari, Italy.

Background: The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known.

Methods: l-arginine (Arg), monomethyl-l-arginine (MMA), l-homoarginine (hArg), asymmetric dimethyl-l-arginine (ADMA), symmetric dimethyl-l-arginine, and l-citrulline (Cit) were measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) in 164 RA patients and 100 age- and sex-matched healthy controls without previous cardiovascular events. Log-transformed reactive hyperemia index (Ln-RHI) evaluated by flow-mediated pulse amplitude tonometry (PAT, EndoPAT2000 device) was assessed as surrogate measure of peripheral vasodilatory capacity in RA patients. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.104038DOI Listing

Case for diagnosis. Subcutaneous nodules in the plantar region.

An Bras Dermatol 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

The authors report a case of mobile and painful nodules on the bilateral plantar surface of a female patient referred by the rheumatology service, where she was being followed-up for rheumatoid arthritis. A nodule excision was performed for differential diagnosis and symptom relief; the histopathological analysis was compatible with a rheumatoid nodule. Although rheumatoid nodules are a common manifestation of rheumatoid arthritis, exclusive plantar involvement is seldom described in the literature. Read More

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http://dx.doi.org/10.1016/j.abd.2020.02.006DOI Listing

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review.

J Autoimmun 2020 Jul 1:102510. Epub 2020 Jul 1.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenetics, Changsha, Hunan, 410011, PR China. Electronic address:

Autoimmune diseases are common diseases of the immune system that are characterized by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune tolerance and the prolonged inflammatory reaction are undisputedly core steps in the initiation and maintenance of autoimmunity. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that belong to the nuclear hormone receptor family and act as ligand-activated transcription factors. There are three different isotypes of PPARs: PPARα, PPARγ, and PPARβ/δ. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102510DOI Listing

Quality of life outcomes in patients undergoing knee replacement surgery: longitudinal findings from the QPro-Gin study.

BMC Musculoskelet Disord 2020 Jul 4;21(1):436. Epub 2020 Jul 4.

National Research Council, Neuroscience Institute - Aging Branch, via Giustiniani, 2, 35128, Padova, Italy.

Background: Many patients report postoperative pain, limited improvement in physical function and poor quality of life (QOL) after knee replacement surgery. Our study uses baseline predictors of change to investigate the QOL of patients with knee osteoarthritis 3-months after knee replacement surgery.

Methods: A prospective observational study was designed to evaluate patients (n = 132) scheduled for uni-compartmental or total knee replacement surgery who were assessed at baseline (preoperatively) and 3-months after. Read More

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http://dx.doi.org/10.1186/s12891-020-03456-2DOI Listing

Cutaneous manifestation of reactive arthritis.

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of dermatology, Besançon University hospital, Besançon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2020.06.010DOI Listing

Is methotrexate contra-indicated in lung involvement of rheumatoid arthritis?

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of Rheumatology, St. James's Hospital, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2020.06.007DOI Listing

Editorial: Psoriatic arthritis; overcoming the challenges by creating opportunities.

Clin Immunol 2020 Jul 1:108519. Epub 2020 Jul 1.

Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Sacramento, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2020.108519DOI Listing

Galantamine in rheumatoid arthritis: A cross talk of parasympathetic and sympathetic system regulates synovium-derived microRNAs and related pathogenic pathways.

Eur J Pharmacol 2020 Jul 1:173315. Epub 2020 Jul 1.

Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.

The acetylcholinesterase inhibitor, galantamine, has shown therapeutic effect in rat model of rheumatoid arthritis. Hence, the current study aims at determining the mode of action of galantamine by examining different synovium-derived microRNAs (miRs) and their related pathogenic pathways. The study also focuses on how parasympathetic and sympathetic pathways in the synovial tissue could affect the mode of action and anti-arthritic effect of galantamine. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173315DOI Listing

Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; MyungSung Christian Medical Center (MCM) Eye Unit, MCM General Hospital and MyungSung Medical School, Addis Ababa, Ethiopia.

Purpose: To evaluate the risk/risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases.

Design: Retrospective cohort study.

Methods: Patients with non-infectious ocular inflammation had been followed longitudinally between 1978-2007 at four US subspecialty uveitis centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.019DOI Listing

Pseudorheumatoid nodule: a variant of granuloma annulare?

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Southern Illinois University School of Medicine, Springfield, IL.

We present an adult woman with subcutaneous nodules without any signs or symptoms of rheumatoid arthritis. These nodules are believed to be pseudorheumatoid nodules, which are considered a deep form of granuloma annulare. This case is unique because these are typically found in children and have rarely been reported in adults. Read More

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Physiological target, molecular evolution and pathogenic functions of a monoclonal ACPA obtained from an RA patient.

Arthritis Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Objectives: We previously isolated a human monoclonal anti-citrullinated protein/peptide antibody (ACPA), CCP-Ab1, which recognizes various citrullinated antigens, from a patient with rheumatoid arthritis (RA). In this study, we aimed to explore the physiological target for CCP-Ab1 and the role of molecular evolution, through affinity maturation of CCP-Ab1, in the onset and the exacerbation of RA.

Methods: We identified and purified the target protein of CCP-Ab1 in plasma, under native conditions. Read More

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http://dx.doi.org/10.1002/art.41426DOI Listing

Sustained cutaneous remission with adalimumab in reactive arthritis: a case series.

Dermatol Ther 2020 Jul 4:e13965. Epub 2020 Jul 4.

Department of Dermatology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital,, Kalwa, India.

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http://dx.doi.org/10.1111/dth.13965DOI Listing

Autoantibodies to Malondialdehyde-Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies.

Arthritis Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA.

Objectives: To examine serum autoantibodies to malondialdehyde-acetaldehyde (MAA) prior to rheumatoid arthritis (RA) diagnosis.

Methods: Anti-MAA antibody isotypes, anti-CCP2, and RF-IgM were measured in pre- and post-RA diagnosis samples (n=214 cases, 210 controls). The timing of elevations in autoantibody concentrations relative to RA diagnosis was explored using separate mixed-models for each antibody and/or isotype. Read More

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http://dx.doi.org/10.1002/art.41424DOI Listing

Long-Term Safety and Effectiveness of the Xanthine Oxidoreductase Inhibitor, Topiroxostat in Japanese Hyperuricemic Patients with or Without Gout: A 54-week Open-label, Multicenter, Post-marketing Observational Study.

Clin Drug Investig 2020 Jul 3. Epub 2020 Jul 3.

Department of Nephrology, Tokyo Medical University, Shinjuku, Tokyo, Japan.

Background And Objectives: Topiroxostat, a selective xanthine oxidoreductase inhibitor, is used for the management of hyperuricemic patients with or without gout in Japan. Accumulating evidence has demonstrated the efficacy of topiroxostat for the treatment of hyperuricemia with or without gout. However, the safety and efficacy of topiroxostat in the clinical setting remain unclear, and there is little large-scale clinical evidence. Read More

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http://dx.doi.org/10.1007/s40261-020-00941-3DOI Listing

Extensor tendon ruptures in rheumatoid wrists.

Eur J Orthop Surg Traumatol 2020 Jul 3. Epub 2020 Jul 3.

Klinik Und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie-Operative Notaufnahme, UKGM Universitätsklinikum Gießen Und Marburg, Rudolf-Buchheim-Str. 7, 35392, Giessen, Germany.

Background And Aims: Rheumatoid arthritis is a chronic inflammatory disease. The associated involvement of hands and tendons is over 90% and impairs overall function. In the course of the disease, the joints are often operated on. Read More

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http://dx.doi.org/10.1007/s00590-020-02731-1DOI Listing

French survey on the crossed needs on sexual health for chronic inflammatory rheumatism patients and healthcare professionals.

Rheumatol Int 2020 Jul 3. Epub 2020 Jul 3.

Rheumatology Department, Clermont-Ferrand University Hospital, 58 rue Montalembert, BP 69, 63003, Clermont-Ferrand, France.

Patients with Inflammatory Chronic Rheumatic disease have approximately three times more sexual dysfunction than the healthy population. However, health professionals do not dare to discuss the subject with them, largely because they do not feel educated on the subject. To define the educational needs in the sexual health of health professionals involved in patient education and those of patients with Inflammatory Chronic Rheumatic disease. Read More

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http://dx.doi.org/10.1007/s00296-020-04630-4DOI Listing

Understanding factors associated with vaccine uptake and vaccine hesitancy in patients with rheumatoid arthritis: a scoping literature review.

Clin Rheumatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychology, Université du Québec à Montréal (UQAM), CP 8888, Sucursale Centre-Ville, Montréal, Quebec, H3C 3P8, Canada.

Due to higher risk of complications associated with vaccine-preventable infections (e.g., influenza, pneumococcus), patients with rheumatoid arthritis (RA) are a priority group for vaccination. Read More

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http://dx.doi.org/10.1007/s10067-020-05059-7DOI Listing

Ultrasound versus dual-energy computed tomography in patients with different stages of acute gouty arthritis: methodological issues on diagnostic value.

Authors:
Siamak Sabour

Clin Rheumatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Epidemiology, School of Public Health and Safety, Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Chamran Highway, Velenjak, Daneshjoo Blvd., Tehran, IR, 1983535511, Iran.

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http://dx.doi.org/10.1007/s10067-020-05067-7DOI Listing

EQ-5D: a plea for accurate nomenclature.

J Patient Rep Outcomes 2020 Jul 3;4(1):52. Epub 2020 Jul 3.

EuroQol Group Research Foundation, Marten Meesweg 107, 3068, AV, Rotterdam, The Netherlands.

Between 1987 and 1990, the EuroQol Group developed a 5-dimension health-related quality of life instrument, originally known as 'the EuroQol instrument', which since 1995 has been called the 'EQ-5D'. For several years, 'the EuroQol instrument' and 'EQ-5D' were both deployed in published materials. In order to standardise nomenclature, the EuroQol Group agreed in 2001 on a terminology glossary containing 12 items; this was recently revised and augmented to include 22 items and can be found on the Group's website ( www. Read More

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http://dx.doi.org/10.1186/s41687-020-00222-9DOI Listing

Subjective and objective evaluation of pain for older adults with knee osteoarthritis in Saudi Arabia: A reliability study.

Niger J Clin Pract 2020 Jul;23(7):934-943

Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.

Aims: This study establishes the reliability and validity of pain pressure threshold (PPT) in evaluating pain for older adults with knee arthritis, and explores the importance of using a standard tool to measure pain in older adults.

Methods: The study consisted of a group of 31 older adult patients with bilateral symptomatic knee osteoarthritis, intra- and inter-rater reliability, and concurrent validity that were assessed for PPT and were compared with standard visual analogue scale (VAS). Physical therapy intervention was provided to combat the pain. Read More

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http://dx.doi.org/10.4103/njcp.njcp_270_19DOI Listing

Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still's disease.

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-218032DOI Listing

Response to: 'Changing the outcome measures, changing the results? The urgent need of a specific Disease Activity Score to adult-onset Still's disease' by Ruscitti .

Ann Rheum Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2020-218143DOI Listing

Association of acute myocardial infarction with seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study.

J Clin Neurosci 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea. Electronic address:

Background: The aim of this nationwide age- and sex matched longitudinal follow up study is to determine the risk of acute myocardial infarction (AMI) associated with the seropositive rheumatoid arthritis (RA) population in Korea.

Methods: Patient data were collected from the National Health Insurance Service Health Screening cohort. RA was identified using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD). Read More

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http://dx.doi.org/10.1016/j.jocn.2020.06.002DOI Listing

Role of Nrf2 in rheumatoid arthritis.

Curr Res Transl Med 2020 Jul 1. Epub 2020 Jul 1.

Chitkara College of Pharmacy, Chitkara University, Punjab, India.

Background: Rheumatoid arthritis comprises the roots of 19th century and is an autoimmune and chronic inflammatory disorder leading to progressive joint destruction. This erosive joint damage is linked with infiltration of leukocytes along with inflammatory destruction and blood cell formation within the synovial membrane, deprivation of cartilage and bone that leads to incapacitative pain. The changes in synovium include its proliferation that leads to pannus formation and this ultimately leads to the invasion and erosions causing the destruction of joints. Read More

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http://dx.doi.org/10.1016/j.retram.2020.05.002DOI Listing

A radiologic parameter that could be applied in the development of sleep apnea in rheumatoid arthritis patients undergoing occipitocervical fusion.

J Orthop Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Orthopedic, China-Japan Friendship Hospital, Peking Union Medical College, Chinese Academy of Medical College, Beijing, 100853, China. Electronic address:

Background: The prevalence of sleep apnea in rheumatoid arthritis (RA) patients with occipitocervical lesions was 79%. Occipitocervical fusion (OCF) could incur sleep apnea or worsen this condition. Recent studies reported that this complication is caused by stenosis of the oropharyngeal airway accompanying a decrease in the occipitoaxial angle (O-C2a). Read More

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http://dx.doi.org/10.1016/j.jos.2020.05.010DOI Listing

Pegloticase treatment of chronic refractory gout: Update on efficacy and safety.

Semin Arthritis Rheum 2020 Jun;50(3S):S31-S38

AMPEL BioSolutions, LLC, Charlottesville, Virginia, U.S.A. Electronic address:

Gout is currently the most frequent cause of inflammatory arthritis worldwide. It results from elevated serum urate and subsequent deposition of monosodium urate crystals in joints and other tissues. While many patients with gout can be managed with conventional agents (e. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.011DOI Listing

Therapeutic approaches in the treatment of gout.

Semin Arthritis Rheum 2020 Jun;50(3S):S24-S30

Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH, United States.

Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1ß in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.010DOI Listing

The biology of urate.

Authors:
Robert T Keenan

Semin Arthritis Rheum 2020 Jun;50(3S):S2-S10

Division of Rheumatology, Duke University School of Medicine, Durham 27710, NC, USA. Electronic address:

Urate is the end-product of the purine metabolism in humans. The dominant source of urate is endogenous purines and the remainder comes through diet. Approximately two thirds of urate is eliminated via the kidney with the rest excreted in the feces. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.007DOI Listing

Unravelling the mysteries of gout by multimodality imaging.

Semin Arthritis Rheum 2020 Jun;50(3S):S17-S23

Department of Radiology, Department of Emergency and Trauma Radiology, University of British Columbia/ Vancouver General Hospital, 899W 12th Ave, Vancouver, BC V5Z 1M9, Canada. Electronic address:

Gout is a common inflammatory arthritis that manifests as an aggregate of variably symptomatic monosodium urate crystals (MSU) in the joints and surrounding tissues in addition to multisystem involvement such as genitourinary and cardiovascular systems. In recent decades, there has been a documented increase in the prevalence and incidence of gout. Risk factors for gout include obesity, dietary influences, hypertension, renal impairment, and diuretic use. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.009DOI Listing

Gout epidemiology and comorbidities.

Semin Arthritis Rheum 2020 Jun;50(3S):S11-S16

Medicine Service, Birmingham VA Medical Center, Birmingham, AL, United States; School of Medicine, Department of Medicine, Division of Rheumatology, University of Alabama at Birmingham, AL, United States.

Objective: To review the epidemiology of gout and associated comorbidities.

Methods: We review the key published studies of the epidemiology of gout and associated comorbidities.

Results: The prevalence of gout ranged 1-4% worldwide and incidence ranged 0. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.008DOI Listing

Current understanding of gout and optimal management strategies.

Authors:
Alexander So

Semin Arthritis Rheum 2020 Jun;50(3S):S1

Service of Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2020.06.008DOI Listing

Understanding cartilage protection in OA and injury: a spectrum of possibilities.

BMC Musculoskelet Disord 2020 Jul 3;21(1):432. Epub 2020 Jul 3.

McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, AB, Canada.

Background: Osteoarthritis (OA) is a prevalent musculoskeletal disease resulting in progressive degeneration of the hyaline articular cartilage within synovial joints. Current repair treatments for OA often result in poor quality tissue that is functionally ineffective compared to the hyaline cartilage and demonstrates increased failure rates post-treatment. Complicating efforts to improve clinical outcomes, animal models used in pre-clinical research show significant heterogeneity in their regenerative and degenerative responses associated with their species, age, genetic/epigenetic traits, and context of cartilage injury or disease. Read More

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http://dx.doi.org/10.1186/s12891-020-03363-6DOI Listing

Is intrinsic lumbar spine shape associated with lumbar disc degeneration? An exploratory study.

BMC Musculoskelet Disord 2020 Jul 3;21(1):433. Epub 2020 Jul 3.

Sackler MSK LAB, Sir Michael Uren Hub, Imperial College London, White City Campus, 86 Wood Lane, London, W12 0BZ, UK.

Background: Lumbar disc degeneration (LDD) is a condition associated with recurrent low back pain (LBP). Knowledge regarding effective management is limited. As a step towards the identification of risk, prognostic or potentially modifiable factors in LDD patients, the aim of this study was to explore the hypothesis that intrinsic lumbar spine shape is associated with LDD and clinical outcomes in symptomatic adults. Read More

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http://dx.doi.org/10.1186/s12891-020-03346-7DOI Listing

Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms.

BMC Mol Cell Biol 2020 Jul 3;21(1):51. Epub 2020 Jul 3.

State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Haidian District, Beijing, 100084, China.

Background: Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, nervous system and reproductive system, while its potential damages on oocyte quality are still unclear. It is known that oocyte quality is essential for healthy conception and the forthcoming embryo development. Read More

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http://dx.doi.org/10.1186/s12860-020-00298-7DOI Listing

Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.

Expert Rev Clin Immunol 2020 Jul 3. Epub 2020 Jul 3.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School , Boston, MA, USA.

Introduction: Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public. Read More

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http://dx.doi.org/10.1080/1744666X.2020.1792778DOI Listing

Effect of Statin Use on Cardiovascular Events and All-Cause Mortality and in Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis involving 148,722 Participants.

Pharmacol Res 2020 Jun 30:105057. Epub 2020 Jun 30.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No.8, Xishiku Street, West District, Beijing, 100034, China. Electronic address:

Background: Immune-mediated inflammatory diseases (IMIDs) are associated with an increased risk of premature cardiovascular disease and all-cause mortality. Given lipid-lowering and anti-inflammatory properties, statins theoretically provide greater survival benefits for patients with IMIDs.

Objective: We aimed to evaluate the impact of statin on all-cause mortality and cardiovascular risk in patients with IMIDs, and examine whether the effect varies between primary prevention and secondary prevention. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.105057DOI Listing

Population-based estimates of healthy working life expectancy in England at age 50 years: analysis of data from the English Longitudinal Study of Ageing.

Lancet Public Health 2020 Jul;5(7):e395-e403

School of Primary, Community and Social Care, Keele University, Newcastle under Lyme, UK; MRC Versus Arthritis Centre for Musculoskeletal Health and Work, University of Southampton, Southampton, UK.

Background: Retirement ages are rising in many countries to offset the challenges of population ageing, but people's capacity to work for more years in their later working life (>50 years) is unclear. We aimed to estimate healthy working life expectancy in England.

Methods: This analysis included adults aged 50 years and older from six waves (2002-13) of the English Longitudinal Study of Ageing (ELSA), with linked mortality data. Read More

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http://dx.doi.org/10.1016/S2468-2667(20)30114-6DOI Listing

Anti-Inflammatory Therapy in Rheumatoid Arthritis to Improve Cardiovascular Outcome.

Can J Cardiol 2020 Mar 27. Epub 2020 Mar 27.

Division of Cardiology, American University Hospital and American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.cjca.2020.03.023DOI Listing

species infections in humans: a systematic review.

J Chemother 2020 Jul 3:1-11. Epub 2020 Jul 3.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

species have been recognized to cause infections in immunocompromised individuals. The purpose of this study was to systemically review all published cases of infections in humans and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. We performed a systematic review of PubMed (through 20 Octrober 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of species infections. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1785742DOI Listing

A Systematic Literature Review of Residual Symptoms and Unmet Need in Patients with Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK.

Objective: To evaluate the nature and burden of residual disease in rheumatoid arthritis (RA) in patients who meet treatment targets. Secondly, for those who did not meet targets, evaluate how much is due to patient symptoms.

Methods: Prospective and retrospective studies were searched in MEDLINE, Embase, and Cochrane Library in the English language from January 1, 2008, to April 18, 2018; conference abstracts (from January 2016 to April 2018) and reference lists of relevant studies were also screened. Read More

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http://dx.doi.org/10.1002/acr.24369DOI Listing

Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Background: Smoking has been associated with increased systemic lupus erythematosus (SLE) risk, but the biologic basis for this association is unknown. We investigated whether women's smoking was positively associated with SLE-associated pro-inflammatory chemokines/cytokines, [stem cell factor (SCF), B-lymphocyte stimulator (BLyS), interferon-inducible protein-10 (IP-10), interferon-alpha (IFN-α)]; or negatively associated with anti-inflammatory cytokine interleukin-10 (IL-10)]; and whether associations were modified by SLE-related autoantibody status.

Methods: The Nurses' Health Study (NHS, n=121,700) and NHSII (n=116,429) cohorts were begun in 1976 and 1989. Read More

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http://dx.doi.org/10.1002/acr.24370DOI Listing

Periprosthetic Joint Infection in Patients Who Have Multiple Prostheses in Place: What Should Be Done with the Silent Prosthetic Joints.

J Bone Joint Surg Am 2020 Jul;102(13):1160-1168

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Although periprosthetic joint infection (PJI) can affect multiple joints concurrently, the majority of patients with multiple prosthetic joints present with PJI of a single joint. Data regarding the optimal management of these patients are limited. We aimed to identify the prevalence, risk factors for a subsequent PJI, and clinical circumstances of PJI in patients with multiple prosthetic joints. Read More

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http://dx.doi.org/10.2106/JBJS.18.01500DOI Listing

Effects of a 12-Week Multifaceted Wearable-Based Program for People With Knee Osteoarthritis: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2020 Jul 3;8(7):e19116. Epub 2020 Jul 3.

Arthritis Research Canada, Richmond, BC, Canada.

Background: Current guidelines emphasize an active lifestyle in the management of knee osteoarthritis (OA), but up to 90% of patients with OA are inactive. In a previous study, we demonstrated that an 8-week physiotherapist (PT)-led counseling intervention, with the use of a Fitbit, improved step count and quality of life in patients with knee OA, compared with a control.

Objective: This study aimed to examine the effect of a 12-week, multifaceted wearable-based program on physical activity and patient outcomes in patients with knee OA. Read More

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http://dx.doi.org/10.2196/19116DOI Listing