318,232 results match your criteria Arthritis & Rheumatology[Journal]


Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

J Med Chem 2019 Apr 23. Epub 2019 Apr 23.

RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently RIP1 kinase inhibitors have advanced into early clinical trials for evaluation in inflammatory diseases such as psoriasis, rheumatoid arthritis and ulcerative colitis, and neuro-logical diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. In this paper we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00318DOI Listing

Semaphorin4A coordinately induces inflammation and fibrosis in systemic sclerosis.

Arthritis Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht.

Objective: To analyze the potential role of Sema4A in inflammatory and fibrotic processes involved in the pathology of systemic sclerosis (SSc).

Methods: Sema4A levels in the plasma of healthy controls (HC, n=10) and systemic sclerosis patients (n=21) were determined by ELISA. The expression of Sema4A and its receptors in monocytes and CD4 T cells from HC and SSc patients (n=6-7, for both) was determined by ELISA and flow cytometry. Read More

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http://dx.doi.org/10.1002/art.40915DOI Listing

Acupressure treatment for methotrexate-induced nausea in arthritis patients.

Authors:
A Lind T Weitoft

Scand J Rheumatol 2019 Apr 23:1-2. Epub 2019 Apr 23.

a Center for Research and Development , Uppsala University/Region Gävleborg , Gävle , Sweden.

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http://dx.doi.org/10.1080/03009742.2019.1579860DOI Listing

Serum drug concentrations to optimize switching from adalimumab to etanercept in rheumatoid arthritis.

Scand J Rheumatol 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Rheumatology , Amsterdam Rheumatology and Immunology Center , Reade , Amsterdam , The Netherlands.

Objectives: Inadequate response to adalimumab can be caused by insufficient blockade of the target tumour necrosis factor (TNF) at low serum concentrations. In such cases, patients may respond to another TNF inhibitor. We investigated whether the serum adalimumab concentration is related to the efficacy of a second TNF inhibitor, etanercept, in rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1080/03009742.2019.1577915DOI Listing

Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.

Int J Rheum Dis 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.

Aim: To assess predictors of alanine aminotransferase (ALT) elevation in methotrexate (MTX) treated rheumatoid arthritis (RA) patients, and to describe the monitoring of liver enzymes, including handling and outcome of elevated ALT.

Methods: All RA patients starting MTX in January, 2005 to April, 2013 at a rheumatology clinic, (Uppsala University Hospital, Sweden) were identified from electronic medical records. Clinical and laboratory data were obtained from medical records, supplemented by telephone interviews. Read More

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http://dx.doi.org/10.1111/1756-185X.13576DOI Listing

Activation of Mast Cells Mediates Inflammatory Response in Psoriasis: Potential New Therapeutic Approach with IL-37.

Dermatol Ther 2019 Apr 22:e12943. Epub 2019 Apr 22.

Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.

Psoriasis (PS) is an autoimmune disorder characterized by chronic inflammatory skin immune-mediated disease which occurs in 2-4% of the worldwide population. PS is associated with an increased risk of cardiovascular disease and depression, and 30% of PS patients are affected with psoriatic arthritis. PS presents excessive keratinocyte proliferation, abnormal differentiation, and elevated mast cell (MC) number. Read More

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http://dx.doi.org/10.1111/dth.12943DOI Listing

RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll-like receptor signaling pathway.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.

Emerging evidence shows that rheumatoid arthritis (RA) progression can be induced by the activation of Toll-like receptor (TLR) signaling pathway. Regulator of G-protein signaling 1 (RGS1) is observed to be a candidate biomarker for arthritis. Accordingly, the present study aims to determine the potential effects of RGS1 mediating TLR on RA. Read More

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http://dx.doi.org/10.1002/jcp.28645DOI Listing

Correction to: Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn's Disease: An Integrated Analysis of Phase II/III Clinical Development Programs.

Drug Saf 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology, University of Connecticut Health Center, 21 South Road, 2nd Floor, Farmington, CT, 06030, USA.

In the original publication of this article, the following correction should be noted in Table 5. Read More

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http://dx.doi.org/10.1007/s40264-019-00816-3DOI Listing

CCL5 and related genes might be the potential diagnostic biomarkers for the therapeutic strategies of rheumatoid arthritis.

Clin Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

The Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Objective: Rheumatoid arthritis (RA) is a common disease of rheumatic diseases. The aim of this study was to identify gene signatures in RA and uncover their potential mechanisms.

Method: Gene expression profiles of GSE1919, GSE55235, GSE55457, and GSE77928 were downloaded from GEO database. Read More

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http://dx.doi.org/10.1007/s10067-019-04533-1DOI Listing

Long-term persistence in patients with osteoporosis receiving denosumab in routine practice: 36-month non-interventional, observational study.

Osteoporos Int 2019 Apr 22. Epub 2019 Apr 22.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Persistence rates over 36 months with denosumab in patients diagnosed with osteoporosis in a real-world setting were examined, along with baseline patient characteristics predictive of persistence. This study represents the longest observational period with denosumab persistence and shows higher persistence rates when compared to bisphosphonates.

Introduction: The study objective was to describe long-term persistence with denosumab among patients treated for osteoporosis in a real-world setting. Read More

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http://link.springer.com/10.1007/s00198-019-04963-2
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http://dx.doi.org/10.1007/s00198-019-04963-2DOI Listing
April 2019
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Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development.

Biomed Res Int 2019 18;2019:8326246. Epub 2019 Mar 18.

Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan.

Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)D ultimately disease onset. Read More

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https://www.hindawi.com/journals/bmri/2019/8326246/
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http://dx.doi.org/10.1155/2019/8326246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442488PMC
March 2019
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Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases.

Case Rep Dermatol 2019 Jan-Apr;11(1):64-70. Epub 2019 Mar 19.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. Read More

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http://dx.doi.org/10.1159/000498881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465707PMC

Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.

Sci Rep 2019 Apr 23;9(1):6374. Epub 2019 Apr 23.

Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan.

Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo-5-oxo-L-norleucine (DON) and mTOR with rapamycin affects immune cells and the arthritis in a mouse model. Read More

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http://www.nature.com/articles/s41598-019-42932-1
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http://dx.doi.org/10.1038/s41598-019-42932-1DOI Listing
April 2019
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GC B cells 'AKT' to blunt BCR signaling.

Authors:
Julie Zikherman

Nat Immunol 2019 Apr 22. Epub 2019 Apr 22.

Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41590-019-0384-3DOI Listing
April 2019
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Economic Potential for Distributed Manufacturing of Adaptive Aids for Arthritis Patients in the U.S.

Geriatrics (Basel) 2018 Dec 6;3(4). Epub 2018 Dec 6.

Department of Materials Science & Engineering, Michigan Technological University, Houghton, MI 49931, USA.

By 2040, more than a quarter of the U.S. population will have diagnosed arthritic conditions. Read More

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http://dx.doi.org/10.3390/geriatrics3040089DOI Listing
December 2018

Subtalar Joint Distraction Arthrodesis Utilizing a Titanium Truss: A Case Series.

J Foot Ankle Surg 2019 Apr 19. Epub 2019 Apr 19.

Faculty, Division of Foot and Ankle Surgery, Western Pennsylvania Hospital, Allegheny Health Network, Pittsburgh, PA. Electronic address:

Subtalar joint distraction arthrodesis has been recommended for the treatment of conditions such as nonunion or malunion of subtalar joint arthrodesis posttraumatic arthritis. Both conditions are difficult to treat, because the deformities created in the frontal and sagittal planes of these conditions are complex. If these malalignments are not addressed, ankle joint instability and wear occur over time. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.11.022DOI Listing

Relationship Between Body Mass Index and Complications in Total Ankle Arthroplasty: A Single Surgeon's Experience in Ninety-Seven Replacements.

J Foot Ankle Surg 2019 Apr 19. Epub 2019 Apr 19.

Surgeon, Oregon Medical Group, Eugene, OR.

The purpose of this study was to compare complication rates of total ankle replacement in 2 groups of patients based on their body mass index (BMI). The total cohort was divided into 2 groups based on BMI. Group 1 included patients with a BMI ≤30 kg/m. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.11.015DOI Listing

Leap Motion Controller-based training for upper extremity rehabilitation in children and adolescents with physical disabilities: A randomized controlled trial.

J Hand Ther 2019 Apr 19. Epub 2019 Apr 19.

Medical Faculty of Cerrahpasa, Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Bakirkoy, Istanbul, Turkey.

Study Design: Randomized controlled trial.

Introduction: Juvenile idiopathic arthritis (JIA), cerebral palsy (CP), and brachial plexus birth injury (BPBI) are the most common disorders that cause upper extremity impairments in children and adolescents. Leap Motion Controller-based training (LMCBT) is a novel therapeutic method for upper extremity rehabilitation. Read More

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http://dx.doi.org/10.1016/j.jht.2019.03.012DOI Listing

Age- and gender-stratified adult myometric reference values of isometric intrinsic hand strength.

J Hand Ther 2019 Apr 19. Epub 2019 Apr 19.

Madison Metropolitan School District, Madison, WI, USA.

Study Design: Descriptive normative.

Introduction: Intrinsic hand strength can be impacted by hand arthritis, peripheral nerve injuries, and spinal cord injuries. Grip dynamometry does not isolate intrinsic strength, and manual muscle testing is not sensitive to change in grades 4 and 5. Read More

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http://dx.doi.org/10.1016/j.jht.2019.03.005DOI Listing

Research Techniques Made Simple: Mouse Models of Atopic Dermatitis.

J Invest Dermatol 2019 May 19;139(5):984-990.e1. Epub 2019 Apr 19.

Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have been heavily used to deepen our understanding of complicated disease mechanisms in AD and to provide a preclinical platform before performing clinical interventional research on novel therapeutic agents in humans. However, what aspects of human AD these mouse AD models faithfully recapitulate is insufficiently understood. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.014DOI Listing

Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1628-1634

a Department of Rheumatology , Dongfang Hospital of Beijing University of Chinese Medicine , Beijing , China.

Chronic inflammation in fibroblast-like synoviocytes (FLSs) induced by pro-inflammatory cytokines such as TNF-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). The neurokinin-1 receptor (NK-1R) is one of the G protein-coupled receptors (GPCRs) mediating the intracellular signalling of substance P (SP). However, the possible implications of NK-1R in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and the pathogenesis of RA have not yet been reported. Read More

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http://dx.doi.org/10.1080/21691401.2019.1573177DOI Listing
December 2019

Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma.

Mar Drugs 2019 Apr 19;17(4). Epub 2019 Apr 19.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Platelet-rich plasma (PRP) is rich in growth factors and has commonly been utilized in the repair and regeneration of damaged articular cartilage. However, the major drawbacks of direct PRP injection are unstable biological fixation and fast or burst release of growth factors. Fucoidan is a heparinoid compound that can bind growth factors to control their release rate. Read More

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http://dx.doi.org/10.3390/md17040236DOI Listing

The Antioxidant from Ethanolic Extract of Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.

Tratt is a Chinese herbal remedy that is used in the treatment of diarrhea, burns, rheumatoid arthritis, and hemorrhage. Despite its use in Asian folk medicine, there are limited reports on the biological activity of fruits. This study focused on the investigation of the antitumor effect of the antioxidative ethanolic extract of fruits (RCE) along with its underlying mechanism of action. Read More

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http://dx.doi.org/10.3390/ijms20081935DOI Listing

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Eur Stroke J 2017 Sep 21;2(3):250-256. Epub 2017 Apr 21.

Division of Epidemiology & Public Health, University of Nottingham, Nottingham, UK.

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women of childbearing age in Sweden.

Patients And Methods: All women aged 15-49 years with live births/stillbirths in 1992-2011 were identified from the Swedish Medical Birth Registry linked with the National Patient Registry. First stroke during the study period was identified. Read More

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http://dx.doi.org/10.1177/2396987317706600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454822PMC
September 2017

National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

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http://dx.doi.org/10.7326/M19-0961DOI Listing

Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity.

Ecotoxicol Environ Saf 2019 Apr 19;178:211-220. Epub 2019 Apr 19.

Beijing Jishuitan Hospital, Peking University Health Science Center, Beijing, 100035, PR China. Electronic address:

Due to similar aerodynamic and micro-nano sized properties between airborne particles and synthetic nanoparticles, a large number of studies have been conducted using carbon-based particles, such as carbon black (CB), carbon nanotubes and graphite, in order to achieve deeper understandings of their adverse effects on human health. It has been reported that particulate matters can aggravate morbidity of patients suffering from bone and joint diseases, e.g. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.029DOI Listing

Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI.

Osteoarthritis Cartilage 2019 Apr 19. Epub 2019 Apr 19.

Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, USA; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, USA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA; Department of Orthopedic Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Health and Exercise Science, J. B. Snow Biomechanics Laboratory, Wake Forest University, Winston-Salem, USA.

Objective: Diet restriction and exercise form key treatments for osteoarthritis (OA) related symptoms in overweight and obese individuals. Although both interventions are known to influence systemic low-grade inflammation, which is related to pain levels and functional limitations, little is known about the potential changes in systemic inflammation as a working mechanism of diet restriction and exercise in knee OA.

Design: Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.009DOI Listing

Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

Attitudes towards Oral Health in Patients with Rheumatoid Arthritis: A Qualitative Study Nested within a Randomized Controlled Trial.

JDR Clin Trans Res 2019 Apr 22:2380084419833694. Epub 2019 Apr 22.

1 Periodontal Research Group, School of Dentistry, Institute of Clinical Sciences, University of Birmingham, and Birmingham Dental Hospital (Birmingham Community Healthcare NHS Foundation Trust), Edgbaston, Birmingham, UK.

Introduction: Patients with rheumatoid arthritis (RA) present a higher incidence and severity of periodontitis than the general population. Our study, Outcomes of Periodontal Treatment in Patients with Rheumatoid Arthritis (OPERA), was a randomized waiting-list controlled trial using mixed methods. Patients randomized to the intervention arm received intensive periodontal treatment, and those in the control arm received the same treatment with a 6-mo delay. Read More

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http://dx.doi.org/10.1177/2380084419833694DOI Listing

Gender-Stratified Prevalence of Psychiatric and Pain Diagnoses in a Primary Care Patient Sample with Fibromyalgia.

Pain Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Family and Community Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Objective: Comorbid psychiatric and pain-related conditions are common in patients with fibromyalgia. Most studies in this area have used data from patients in specialty care and may not represent the characteristics of fibromyalgia in primary care patients. We sought to fill gaps in the literature by determining if the association between psychiatric diagnoses, conditions associated with chronic pain, and fibromyalgia differed by gender in a primary care patient population. Read More

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http://dx.doi.org/10.1093/pm/pnz084DOI Listing
April 2019
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Association Between , Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis.

J Interferon Cytokine Res 2019 Apr 22. Epub 2019 Apr 22.

7 Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Faiyum, Egypt.

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease. We aimed to measure the level of miR-155 and its genetic variant rs767649 in patients with RA and to evaluate their relationship with ischemia-modified albumin (IMA). The study was performed on 79 patients with RA (group I) and 78 healthy control participants (group II). Read More

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http://dx.doi.org/10.1089/jir.2019.0001DOI Listing

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A, a key cytokine involved in psoriasis (PsO) and psoriatic arthritis (PsA) development, and has shown rapid and long lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Monoclonal antibody therapies may be associated with the production of treatment-emergent anti-drug antibodies (TE-ADA) that can affect drug pharmacokinetics, diminish clinical responses via inhibition of target binding, or cause hypersensitivity reactions. Secukinumab exhibited minimal immunogenicity up to 52 weeks in patients with moderate-to-severe plaque psoriasis, as evidenced by TE-ADA in <1% patients. Read More

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http://dx.doi.org/10.1111/jdv.15637DOI Listing

Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through AKT/FOXO1 signaling.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Dermatology department, Shaanxi hospital of traditional Chinese medicine, Xi'an, China.

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one (eriodictyol), a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antiarthritis activities. However, the effects of eriodictyol on the rheumatoid proliferation, apoptosis, and inflammatory response of arthritis fibroblast-like synoviocytes (RA-FLS) remain unclear. Thus, the objective of this study was to examine the effects of eriodictyol on RA-FLS survival, apoptosis, and inflammatory response, and further explore the potential underlying mechanisms. Read More

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http://dx.doi.org/10.1002/jcb.28724DOI Listing

Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells: application in rheumatoid arthritis and leukemia patients.

Ther Drug Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Chemistry, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands.

Background: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment. To date, assessment of FPGS catalytic activity relies on assays utilizing radioactive substrates which are labor-intensive and require relatively large numbers of cells. Here, we describe a non-radioactive, UHPLC-MS/MS-based method allowing sensitive and accurate measurements of FPGS activity in low cell numbers (i. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000638DOI Listing

Evaluation of the Painful Total Knee Arthroplasty.

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Beaumont Health, Departments of Orthopaedic Surgery and Research, Royal Oak, MI (Dr. Flierl, Dr. Sobh, and Dr. Baker), the Princeton HealthCare System, Department of Orthopaedic Surgery, Princeton, NJ (Dr. Culp), and the Rush University Medical Center, Midwest Orthopaedics at Rush, Chicago, IL (Dr. Sporer).

Total knee arthroplasty (TKA) has been associated with notable improvements in health-related quality of life of patients with end-stage knee arthritis. Although most patients experience substantial symptomatic relief after TKA, up to 19% of patients are unsatisfied with their outcome. With the dramatic, projected increase in the number of TKAs performed annually, it is crucial to appreciate the various modes of failure associated with this procedure. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00083DOI Listing

Acute Flares of Knee Osteoarthritis (the ACT-FLARE Study): Protocol for a Web-Based Case-Crossover Study in Community-Dwelling Adults.

JMIR Res Protoc 2019 Apr 22;8(4):e13428. Epub 2019 Apr 22.

Primary Care Centre Versus Arthritis, Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom.

Background: The cardinal feature of osteoarthritis (OA) is pain. Although heterogeneity in pain and function have been demonstrated in the long-term course of OA, the more proximate determinants of acute flare-ups remain less clear. How short-term intermittent or transient exposures trigger acute flare-ups has important implications for effective and sustainable self-management strategies. Read More

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https://www.researchprotocols.org/2019/4/e13428/
Publisher Site
http://dx.doi.org/10.2196/13428DOI Listing
April 2019
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Depression and multimorbidity: Considering temporal characteristics of the associations between depression and multiple chronic diseases.

Health Psychol 2019 Apr 22. Epub 2019 Apr 22.

Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center.

Objectives: Depression frequently co-occurs with multiple chronic diseases in complex, costly, and dangerous patterns of multimorbidity. The field of health psychology may benefit from evaluating the temporal characteristics of depression's associations with common diseases, and from determining whether depression is a central connector in multimorbid disease clusters. The present review addresses these issues by focusing on 4 of the most prevalent diseases: hypertension, ischemic heart disease, arthritis, and diabetes. Read More

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http://dx.doi.org/10.1037/hea0000737DOI Listing

Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD.

Background: Scleromyxedema (SMX) is a rare systemic sclerosis mimic that often responds to intravenous immunoglobulin therapy (IVIG), yet the resulting clinical and biochemical changes have not been well characterized.

Methods: Fifteen patients with SMX were recruited for the study. Clinical information and peripheral blood mononuclear cells for flow cytometry were obtained immediately before and again 1-2 weeks after receiving IVIG therapy. Read More

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http://dx.doi.org/10.1002/acr.23908DOI Listing

Patient- and Rheumatologist- Perspectives Regarding Challenges to Achieving Optimal Disease Control in Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL.

Objective: To identify and prioritize patient- and rheumatologist-perceived barriers to achieving disease control.

Methods: RA patients and rheumatologists from the Consortium of Rheumatology Researchers of North America (Corrona) registry were invited by email to participate in nominal groups (NGs). Two separate lists of barriers were created, one from RA-patient-only NGs and other from rheumatologist-only NGs, and barriers were sorted into themes. Read More

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http://dx.doi.org/10.1002/acr.23907DOI Listing
April 2019
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Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Objectives: Individuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early-onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary "idiopathic" systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. Read More

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http://dx.doi.org/10.1002/art.40913DOI Listing

Associations of joint line tenderness and patellofemoral grind with long-term knee joint outcomes: Data from the Osteoarthritis Initiative.

Arthritis Care Res (Hoboken) 2019 Apr 22. Epub 2019 Apr 22.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.

Objective: To examine whether joint line tenderness and patellofemoral grind from physical examination were associated with cartilage volume loss, worsening of radiographic osteoarthritis, and risk of total knee replacement.

Methods: This study examined 4353 Osteoarthritis Initiative participants. For each of joint line tenderness and patellofemoral grind, the patterns were defined as no (none at baseline and 1-year), fluctuating (present at either time-point), and persistent (present at both time-points). Read More

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http://dx.doi.org/10.1002/acr.23906DOI Listing

Long term outcome of ustekinumab therapy for Behçet's disease.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

Sorbonne Université, Département de Médecine Interne et Immunologie Clinique, F-75013, Paris, France.

Objective: Oral ulcers (OU), the hallmark lesion of Behçet's disease (BD), can be disabling and resistant to conventional treatment. There remains a need for safe and effective treatment. We report here the long term safety and efficacy of ustekinumab therapy for BD related OU resistant to colchicine. Read More

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http://dx.doi.org/10.1002/art.40912DOI Listing

Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture.

Osteoporos Sarcopenia 2019 Mar 15;5(1):6-10. Epub 2019 Mar 15.

University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Rheumatology, Ashton Road, Lancaster, Lancashire, UK.

Objectives: Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF.

Methods: This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004-2016. Read More

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http://dx.doi.org/10.1016/j.afos.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452922PMC

Birt-Hogg-Dubé syndrome initially diagnosed as tuberous sclerosis complex.

JAAD Case Rep 2019 Apr 5;5(4):368-371. Epub 2019 Apr 5.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453834PMC

Inflammatory variant of pachydermoperiostosis responding to methotrexate: a report of two cases.

Oxf Med Case Reports 2019 Apr 16;2019(4):omy128. Epub 2019 Apr 16.

Department of Rheumatology, National Center for Rheumatic Diseases(NCRD), Kathmandu 44600, Nepal.

Pachydermoperiostosis is a rare genetic disorder characterized by skin thickening, digital clubbing and periostitis. The pathogenesis is incompletely understood and there are no proven treatments for its manifestations. Although arthritis has been reported in 20-40% cases, most are non-inflammatory in nature and usually treated symptomatically with steroids or NSAIDs. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy12
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http://dx.doi.org/10.1093/omcr/omy128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467096PMC
April 2019
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Full-Blown Rheumatoid Heart and Vessels Associated with Rheumatoid Arthritis.

Heart Views 2018 Jul-Sep;19(3):102-105

Division of Cardiology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

We report the case of a 54-year-old female patient with a history of rheumatoid arthritis (RA) who presented with dyspnea on exertion. Her pulsation on both arms was weak. Magnetic resonance (MR) angiography revealed Takayasu's arteritis (TA) characterized by multiple stenosis involving innominate, left common carotid, and left subclavian arteries. Read More

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http://www.heartviews.org/text.asp?2018/19/3/102/254344
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http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_145_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448469PMC
April 2019
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Total hip arthroplasty in the setting of tuberculosis infection of the hip: a systematic analysis of the current evidence.

Expert Rev Med Devices 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Department of Orthopaedic Surgery , Cleveland Clinic , Cleveland , OH , USA.

Introduction: Total hip arthroplasty (THA) is a viable option to restore mobility and relieve pain in patients with severe post-tuberculous arthritis, but has been controversial due to concerns of disease reactivation. Over the past several decades, a number of authors have reported outcomes of THA for tuberculosis (TB) infections. However, there is marked heterogeneity in regard to disease activity, surgical approaches, and the use of chemoprophylaxis in these studies. Read More

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http://dx.doi.org/10.1080/17434440.2019.1606710DOI Listing

IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors.

Am J Hum Genet 2019 Apr 6. Epub 2019 Apr 6.

Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

Despite significant progress in annotating the genome with experimental methods, much of the regulatory noncoding genome remains poorly defined. Here we assert that regulatory elements may be characterized by leveraging local epigenomic signatures where specific transcription factors (TFs) are bound. To link these two features, we introduce IMPACT, a genome annotation strategy that identifies regulatory elements defined by cell-state-specific TF binding profiles, learned from 515 chromatin and sequence annotations. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.03.012DOI Listing

Corticosteroids and Methotrexate as Adjuvants to Costimulation Blockade in Nonhuman Primate Renal Transplantation.

Clin Transplant 2019 Apr 21:e13568. Epub 2019 Apr 21.

Emory Transplant Center, Emory University, Atlanta, GA.

Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates of early rejection, prompting a search for agents to pair with belatacept. Methotrexate (MTX) is an antimetabolite that has been found to be complimentary with abatacept, a lower affinity CD28-B7-specific analogue of belatacept, in the treatment of rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1111/ctr.13568DOI Listing