335,309 results match your criteria Arthritis & Rheumatology[Journal]


[Treatment strategies in psoriatic arthritis].

Dtsch Med Wochenschr 2020 Jun 3;145(11):773-780. Epub 2020 Jun 3.

Abteilung Rheumatologie, Goethe-Universität Frankfurt/Main.

Psoriatic arthritis is a heterogeneous immune-mediated disease that usually involves skin and joints but can also affect entheses and extraarticular structures in the disease course. In addition, associated diseases must be considered when choosing the appropriate therapeutic strategy. Different recommendations for treatment of psoriatic arthritis are available for clinical use. Read More

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http://dx.doi.org/10.1055/a-0964-0231DOI Listing

Adaptive Engagement and Support Model for People with Chronic Health Conditions: Using Combined Content Analysis to Assess Online Health Communities.

J Med Internet Res 2020 Jun 3. Epub 2020 Jun 3.

Health Union, LLC, 1217 Sansom Street2nd Floor, Philadelphia, US.

Background: With the pervasiveness of social media, online health communities (OHC) are an important tool for facilitating information sharing and support among people with chronic health conditions. Importantly, OHCs offer insight into conversations about the lived experiences of people with particular health conditions. What is less known is what aspects of OHCs are important to maintain safe and productive conversations that support health. Read More

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http://dx.doi.org/10.2196/17338DOI Listing

T2* mapping in an equine articular groove model - visualizing changes in collagen orientation.

J Orthop Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.

T2* mapping is promising for the evaluation of articular cartilage collagen. In this work, a groove model in a large animal is used as a model for post-traumatic arthritis. We hypothesized that T2* mapping could be employed to differentiate between healthy and (subtly) damaged cartilage. Read More

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http://dx.doi.org/10.1002/jor.24764DOI Listing

"To be lonely in your own loneliness": The interplay between self-perceived loneliness and rheumatoid arthritis in everyday life: A qualitative study.

Musculoskeletal Care 2020 Jun 3. Epub 2020 Jun 3.

University College Lillebaelt, Odense, Denmark.

Objective: Loneliness has a negative impact on physical health, and rheumatoid arthritis symptoms can lead to social isolation. However, there is a lack of research exploring patients' perspectives on self-perceived loneliness in everyday life with rheumatoid arthritis. The purpose of this study was to gain insight into the meaning and importance of self-perceived loneliness among adult patients diagnosed with rheumatoid arthritis. Read More

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http://dx.doi.org/10.1002/msc.1480DOI Listing

Trajectories of Structural Disease Progression in Knee Osteoarthritis.

Arthritis Care Res (Hoboken) 2020 Jun 3. Epub 2020 Jun 3.

Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopaedic Treatments (PIVOT) Center, Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

Objective: Knee osteoarthritis (OA) is a heterogeneous disease, with most patients experiencing slow disease progression and some with rapid deterioration. We aimed to identify groups of persons with symptomatic knee OA experiencing rapid structural progression.

Methods: We selected participants from the Osteoarthritis Initiative with baseline (BL) Kellgren-Lawrence (KL) grade 1 - 3, knee pain, and with joint space width (JSW) on fixed-flexion knee radiographs assessed at BL and ≥1 follow-up over 8 years. Read More

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http://dx.doi.org/10.1002/acr.24340DOI Listing

Four-corner fusion versus proximal row carpectomy : a retrospective review with a minimal follow-up of 9 years.

Acta Orthop Belg 2020 Mar;86(1):146-150

A retrospective survey on the long-term outcomes of both proximal row carpectomy (PRC) and scaphoidectomy with 4-corner arthrodesis (4CA) was conducted. Seventeen PRC and nine 4CA wrists were retrieved with a minimal follow-up of 9 years. Pain, satisfaction and disability were not significantly different. Read More

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Total ankle replacement : comparison of the outcomes of STAR and Mobility.

Acta Orthop Belg 2020 Mar;86(1):109-114

Total Ankle Replacement is a recognised treatment for end-stage ankle arthritis and an alternative to arthrodesis. This study reviews a single centre series of prospectively collected outcome measures to determine whether the Mobility performs better than the Scandinavian ankle replacement. The primary outcome measure was the survivorship. Read More

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Joint needle aspiration compared to tissue samples in septic arthritis of the native knee.

Acta Orthop Belg 2020 Mar;86(1):64-68

Culture of the causative infectious agent is the only definitive method of diagnosing septic arthritis and can be identified by culture of synovial fluid (SF) or by tissue cultures (TC) obtained at surgery. The aim of this study is to compare the cultures of joint needle aspiration (JNA) with tissue cultures obtained at surgery. 52 patients treated for a suspicion of a septic arthritis of the native knee were retrospectively reviewed. Read More

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Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance.

J Periodontol 2020 Jun 3. Epub 2020 Jun 3.

Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

Background: During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor κB ligand (RANKL), which is responsible for osteoclast differentiation and activation. In periodontitis-affected tissues, the imbalance between T-helper type-17 (Th17) and T-regulatory (Treg) lymphocyte activity favors this RANKL overexpression. In this context, immunotherapeutic strategies aimed at modulating this Th17/Treg imbalance could eventually arrest the RANKL-mediated alveolar bone loss. Read More

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http://dx.doi.org/10.1002/JPER.20-0055DOI Listing

The MAP-Hand: Psychometric properties and differences in activity performance between patients with carpometacarpal osteoarthritis and rheumatoid arthritis.

J Rehabil Med 2020 May 28. Epub 2020 May 28.

Department of Rheumatology, Diakonhjemmet Hospital, , 0370 Oslo, Norway. E-mail:

Objective: To assess construct validity (Rasch analyses) of the Measurement of Activity Performance of the Hand (MAP-Hand) in people with carpometacarpal osteoarthritis (CMC1 OA), and to explore differences in activity performance between people with CMC1 OA and those with rheumatoid arthritis.

Design: Cross-sectional study.

Subjects: A total of 180 people with CMC1 OA referred for surgical consultation were recruited from rheumatology clinics in Norway, and 340 people with rheumatoid arthritis were recruited from outpatient rheumatology clinics in the UK. Read More

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http://dx.doi.org/10.2340/16501977-2696DOI Listing

Reverse shoulder replacement: a day-case procedure.

JSES Int 2020 Jun 29;4(2):397-399. Epub 2020 Apr 29.

Department of Trauma and Orthopaedics, Bedford Hospital NHS Trust, Bedford, United Kingdom.

Background And Hypothesis: Reverse shoulder arthroplasty (RSA) is an increasingly popular treatment modality for glenohumeral joint arthritis in association with rotator cuff arthropathy. A prolonged hospital stay following joint arthroplasty risks increased complications for patients plus financial implications for institutions. We hypothesized that RSA could be safely and effectively carried out as an outpatient procedure with reduced risks to patients and institutional costs. Read More

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http://dx.doi.org/10.1016/j.jseint.2020.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256897PMC

Lateral Meniscal Oblique Radial Tears Are Common With ACL Injury: A Classification System Based on Arthroscopic Tear Patterns in 600 Consecutive Patients.

Orthop J Sports Med 2020 May 19;8(5):2325967120921737. Epub 2020 May 19.

Department of Orthopedic Surgery, Columbia Orthopedic Group, Columbia, Missouri, USA.

Background: Meniscal root tears and ramp lesions have been rigorously characterized in recent literature. However, one of the most common lateral meniscal injuries identified with an acute anterior cruciate ligament (ACL) disruption, a posterior horn lateral meniscal oblique radial tear (LMORT), has not been thoroughly described.

Purpose: To determine the incidence of all meniscal tears and, more specifically, the incidence of posterior horn LMORTs in a multicenter cohort of consecutive, acute ACL reconstructions. Read More

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http://dx.doi.org/10.1177/2325967120921737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238316PMC

Possible Anti-inflammatory Effects of Mesenchymal Stem Cells Transplantation via Changes in CXCL8 Levels in Patients with Refractory Rheumatoid Arthritis.

Int J Mol Cell Med 2019 ;8(3):191-199

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The synovial- lining cells have been involved with rheumatoid arthritis (RA) through the secretion of various cytokines and chemokines. Increased levels of these cytokines and chemokines are seen first in the synovial and subsequently in the bloodstream of RA patients. The synovial and circulating levels of CXCL8, CXCL12, and CXCL13 are higher in the RA patients than in the healthy subjects, causing migration of immune cells to the joints, which is associated with increased joint destruction. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.3.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241844PMC
January 2019

Comorbidities and their link with individual health status: A cross-sectional analysis of 23,892 people with knee and hip osteoarthritis from primary care.

J Comorb 2020 Jan-Dec;10:2235042X20920456. Epub 2020 May 14.

Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

Objectives: Robust data on the impact of comorbidities on health in people with osteoarthritis (OA) are lacking, despite its potential importance for patient management. Objectives were to determine coexisting conditions in people with OA in primary care and whether more comorbidities were linked with individual health status.

Methods: A retrospective analysis of 23,892 patients with knee and hip OA was conducted to determine comorbidities present (number/clusters) and how these linked with pain intensity (0-100), widespread pain (site numbers), medication usage (paracetamol, nonsteroidal anti-inflammatory drugs, opioids), quality of life EuroQol five dimension scale (EQ-5D), and physical function (walking speed) using independent -tests or test. Read More

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http://dx.doi.org/10.1177/2235042X20920456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238776PMC

Arthroscopic Single-Row Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears.

Arthrosc Tech 2020 May 25;9(5):e675-e681. Epub 2020 Apr 25.

Florida Sports Injury & Orthopaedic Institute, Clermont, Florida, U.S.A.

Massive, irreparable rotator cuff tears are challenging to manage. Often, these tears are not amenable to primary repair and necessitate additional treatment options. This is especially true in patients with absent glenohumeral arthritis in the setting of a massive, irreparable rotator cuff tear. Read More

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http://dx.doi.org/10.1016/j.eats.2020.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253793PMC

Arthroscopic Fixation of a Large Osteochondral Fragment From the Glenoid After First Episode Dislocation.

Arthrosc Tech 2020 May 25;9(5):e663-e667. Epub 2020 Apr 25.

National Institute of Traumatology and Orthopedics (INTO), Rio de Janeiro, Brazil.

Osteochondral lesions of the glenoid are not so uncommon after traumatic cases of shoulder dislocation and can be a challenge to the shoulder surgeon because of the technical difficulty and the potential to progression to shoulder arthritis. An all-arthroscopic technique of fixation of a large osteochondral fragment is used to allow optimal visualization and reduction, minimize the morbidity of the open approach, and provide good functional results. Read More

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http://dx.doi.org/10.1016/j.eats.2020.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253778PMC

Prevalence of Cancer in Rheumatoid Arthritis: Epidemiological Study Based on the National Health and Nutrition Examination Survey (NHANES).

Cureus 2020 Apr 28;12(4):e7870. Epub 2020 Apr 28.

Internal Medicine, University of Pittsburgh Medical Center (UPMC) Pinnacle, Lancaster, USA.

Rheumatoid arthritis (RA) is a multi-system autoimmune disease with significant morbidity and healthcare burden. It is an inflammatory condition and has been associated with lymphomas, with or without the presence of immunosuppressive therapy. However, the association of rheumatoid arthritis with other malignancies has been inconsistent. Read More

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http://dx.doi.org/10.7759/cureus.7870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255534PMC

The Link Between Rheumatoid Arthritis and Dementia: A Review.

Cureus 2020 Apr 27;12(4):e7855. Epub 2020 Apr 27.

Internal Medicine, American University of Integrative Sciences School of Medicine, St. Michael, BRB.

Background:  This study explored the relationship between rheumatoid arthritis (RA) and dementia. These two diseases are a significant health burden that affects the older population, although they have also manifested in young people to a smaller extent.

Methodology:  The study entailed a detailed literature review of articles on RA and dementia. Read More

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http://dx.doi.org/10.7759/cureus.7855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255531PMC

Physical Activity Intervention for Loneliness (PAIL) in community-dwelling older adults: a randomised feasibility study.

Pilot Feasibility Stud 2020 23;6:73. Epub 2020 May 23.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Background: Low quality social relationships in older adults are strongly associated with feelings of loneliness. Physical activity interventions could reduce loneliness and improve psychological well-being, among other health benefits. The aim of this study was to examine the feasibility of a Physical Activity Intervention for Loneliness (PAIL) in community-dwelling older adults at risk of loneliness. Read More

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http://dx.doi.org/10.1186/s40814-020-00587-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245022PMC

Three-Dimensional Morphometric Analysis of Penetrative Depth and Size of Nonarthritic and Degenerative Arthritic Glenoids: Implications for Glenoid Replacement in Shoulder Arthroplasty.

Clin Orthop Surg 2020 Jun 14;12(2):224-231. Epub 2020 May 14.

Department of Orthopaedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Shoulder arthroplasty is technically demanding and relies heavily on the precision of surgical techniques. Proper glenoid component sizing plays a crucial role in successful shoulder arthroplasty. We measured the size and penetrative depth of the glenoid for peg or screw fixation in nonarthritic and degenerative arthritic shoulders by using three-dimensional computed tomography to determine the reference dimensions of the glenoid in nonarthritic and degenerative arthritic shoulders. Read More

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http://dx.doi.org/10.4055/cios19088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237260PMC

Comprehensive molecular and clinical analysis of adalimumab and etanercept therapeutic potential in patients with psoriatic arthritis.

Postepy Dermatol Alergol 2020 Apr 6;37(2):262-268. Epub 2020 May 6.

Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland.

Introduction: Adalimumab and etanercept are drugs used in anti-TNF therapy in patients with psoriasis and psoriatic arthritis. Despite the molecular targeting of these drugs, the loss of pharmacological response to treatment is observed in patients. The development of personalized medicine makes it possible to use not only clinical parameters of disease severity, but also molecular marker systems. Read More

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http://dx.doi.org/10.5114/ada.2020.94847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262816PMC

Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis.

Clin Rheumatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People's Republic of China.

As the precursors of macrophages and osteoclasts, monocytes play an important role in the pathogenesis of rheumatoid arthritis (RA). Since the deficiency of zinc-finger protein A20 in myeloid cells triggers erosive polyarthritis resembling RA, A20 in monocytes may play a protective role in RA. In the present study, we aimed to investigate the abnormality of monocyte subtypes and the expression of zinc-finger protein A20 in RA. Read More

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http://dx.doi.org/10.1007/s10067-020-05137-wDOI Listing

How to Optimize Reverse Shoulder Arthroplasty for Irreparable Cuff Tears.

Curr Rev Musculoskelet Med 2020 Jun 3. Epub 2020 Jun 3.

Roth McFarlane Centre, London, ON, Canada.

Purpose Of The Review: Reverse shoulder arthroplasty (RSA) is commonly considered as one of the options for surgical management of the functionally irreparable rotator cuff tear (FIRCT). This article reviews tips and tricks to optimize the outcome of RSA when performed specifically for this indication.

Recent Findings: RSA has been reported to provide satisfactory outcomes in a large proportion of patients with FIRCTs. Read More

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http://dx.doi.org/10.1007/s12178-020-09655-7DOI Listing

Redox signalling in physiology, ageing and disease.

Biogerontology 2020 Jun 2. Epub 2020 Jun 2.

School of Medicine, Physiology, National University of Ireland, Galway, H91 W5P57, Ireland.

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http://dx.doi.org/10.1007/s10522-020-09885-9DOI Listing

Fully automatic quantitative software for assessment of minute finger joint space narrowing progression on radiographs: evaluation in rheumatoid arthritis patients with long-term sustained clinical low disease activity.

Jpn J Radiol 2020 Jun 2. Epub 2020 Jun 2.

Faculty of Health Sciences, Hokkaido University, North-12 West-5, Kita-ku, Sapporo, 060-0812, Japan.

Purpose: Rheumatoid arthritis (RA) causes joint space narrowing (JSN) as a form of joint destruction. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. This study aims to evaluate the application of "machine vision" for radiographic image of the finger joints. Read More

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http://dx.doi.org/10.1007/s11604-020-00996-4DOI Listing

Association of rheumatoid arthritis with hearing loss: a systematic review and meta-analysis.

Rheumatol Int 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, General Hospital of Kastoria, Kastoria, Greece.

Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the worldwide population. RA is associated with multiple extra-articular manifestations (EAMs). Middle ear, cochlea and the auditory nerve are suspected sites of RA activity and hearing loss is a possible novel EAM of RA. Read More

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http://dx.doi.org/10.1007/s00296-020-04609-1DOI Listing

Rheumatologic Disorders and the Nervous System.

Continuum (Minneap Minn) 2020 Jun;26(3):591-610

Purpose: This article describes the neurologic manifestations of systemic autoimmune diseases.

Recent Findings: Systemic autoimmune diseases can be associated with a wide spectrum of neurologic comorbidities involving the central and peripheral nervous systems. Systemic lupus erythematosus (SLE) can be associated with a number of manifestations predominantly affecting the central nervous system (CNS), whereas peripheral neuropathy is less common. Read More

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http://dx.doi.org/10.1212/CON.0000000000000856DOI Listing

Acute septic elbow monoarthritis with associated Neisseria gonorrhoeae bacteraemia: an uncommon presentation of an old disease.

Infez Med 2020 Jun;28(2):253-257

Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Neisseria gonorrhoeae is an uncommon present-day cause of septic arthritis. It is generally seen in the younger patient population and is often difficult to isolate in the lab. Blood cultures performed as routine work are usually negative, and when positive tend to be seen in the classic form of disseminated gonococcal infection. Read More

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Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.

Eur J Endocrinol 2020 Jul;183(1):73-81

Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD.

Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. Read More

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http://dx.doi.org/10.1530/EJE-20-0150DOI Listing

Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases.

Neurology 2020 Jun 2. Epub 2020 Jun 2.

From the Departments of Clinical Immunology and Internal Medicine (Y.A., S.T., G.L., B.H., N.C., K.M., O.B.), Immunobiology (M.M.), and Biostatistics, Public Health, and Medical Information (B.G.), Pitié-Salpêtrière Hospital, APHP, Sorbonne Universities; Myology Research Centre (Y.A., O.B.), INSERM, UMRS 974, Paris; Department of Pneumology (Y.U., H.N.), APHP, Avicenne Hospital, INSERM U1272, Université Sorbonne Paris Nord, Bobigny; Department of Internal Medicine (L.G., A. Marquet), Lyon Sud Hospital, Lyon Sud University, Paris; Reference Centre for Rare Autoimmune Diseases (A. Meyer) and Medical Intensive Care Unit, Hautepierre Hospital (V. Castelain), Hôpitaux Universitaires de Strasbourg, Strasbourg University; Division of Pneumology (R.B.), Bichat Hospital, AP-HP, Paris-Diderot University, Paris; Department of Pneumology (F.G., P.P.), Centre Hospitalier Universitaire, Angers University; Department of Internal Medicine Infectieuses (C.D.), CHU de Martinique, Fort de France; Departments of Internal Medicine and Clinical Immunology (S.A.) and Internal Medicine and Systemic Diseases (H.D.), François-Mitterrand University Hospital, University of Bourgogne-Franche-Comté, Dijon; Internal Medicine Department (B.T., A.B.), Cochin Hospital, AP-HP, René Descartes University, Paris; Department of Internal Medicine (C.G., N.L.), Henri Mondor Hospital, Paris Est Créteil University, Créteil, France; Department of Neurology (N.V.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Internal Medicine (E.D.), Hôpital Bretonneau Tours, Tours University; Internal Medicine Department (A.S.), Hôpital Robert-Debré, Reims University; Departments of Rheumatology (T.M.) and Internal Medicine (L.D.S.M.), Bretagne Occidentale University, Centre Hospitalo-Universitaire de Brest; Department of Internal Medicine (S.H.), CHU de Besançon; Department of Internal Medicine (C.B.-D.), Centre Hospitalier Général de Niort; Department of Internal Medicine (N.T.), Nice University, CHU Nice; Department of Internal Medicine (P.C.), Institut Mutualiste Montsouris, Paris; Department of Internal Medicine (M.G.), Jean Verdier Hospital, Paris Seine-Saint-Denis University, Bondy; Department of Internal Medicine (A. Mekinian), Saint Antoine Hospital, APHP, Sorbonne Universities, Paris; Department of Pneumology CHU (J.C.M.), Poitiers University; Department of Pneumology (A.T.), Hôpital Saint-Louis, APHP, Sorbonne Paris Cité, University Paris-Diderot, Paris; Department of Respiratory Medicine (V. Cottin), National Reference Center for Rare Pulmonary Diseases, Hospices Civils de Lyon, Claude Bernard University Lyon 1, Lyon University; Department of Pneumology (D.I.-B.), European George Pompidou Hospital, APHP, Paris V University; Department of Pneumology (S.P.-H.), Sainte-Camille Hospital, Bry-sur-Marne; Department of Pneumology (C.B.), Foch Hospital, Saint Quentin en Yveline University, Suresnes; and Department of Immunology (N.F.), Lyon-Sud Hospital, Hospices Civils-de-Lyon, Pierre-Bénite, France.

Objectives: The predominance of extramuscular manifestations (e.g., skin rash, arthralgia, interstitial lung disease [ILD]) as well as the low frequency of muscle signs in anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis caused us to question the term myositis-specific antibody for the anti-MDA5 antibody, as well as the homogeneity of the disease. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009727DOI Listing

Monoterpenes-containing PEGylated transfersomes for enhancing joint cavity drug delivery evidenced by CLSM and double-sited microdialysis.

Mater Sci Eng C Mater Biol Appl 2020 Aug 14;113:110929. Epub 2020 Apr 14.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China.

The synovial tissues are natural sites of drug delivery for the treatment of rheumatoid arthritis. Our previous study showed that mixed monoterpenes edge-activated PEGylated transfersomes (MMPTs) could significantly enhance the percutaneous absorption of sinomenine (SIN), an anti-inflammation drug. The aim of this study was to investigate the potential of MMPTs for delivery of SIN to the synovial tissues in joint cavities. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110929DOI Listing

Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.

Arthritis Res Ther 2020 Jun 1;22(1):127. Epub 2020 Jun 1.

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Background: Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great value to improve current diagnostic methods and develop new strategies for evaluating patients with suspected PAH. Read More

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http://dx.doi.org/10.1186/s13075-020-02218-8DOI Listing

Study of Medical Ultrasound for Rhizarthrosis (SUR): study protocol for a randomized controlled single-center pilot-trial.

Trials 2020 Jun 1;21(1):450. Epub 2020 Jun 1.

Department of Hand Surgery, Upper Extremity and Foot Surgery, Center for Orthopedics and Trauma Surgery, Hospital Waldfriede, Argentinische Allee 40, 14163, Berlin, Germany.

Background: Rhizarthrosis (trapeziometacarpal osteoarthritis) is the second most common site of osteoarthritis in the hand affecting 10-30% of adults over the age of 50. Up to four times as many women as men have rhizarthrosis. Clinical symptoms include functional disability of the thumb, pain, joint swelling, and reduced strength. Read More

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http://dx.doi.org/10.1186/s13063-020-04375-2DOI Listing

Rituximab use as induction therapy for lupus nephritis: a systematic review.

Lupus 2020 Jun 2:961203320928412. Epub 2020 Jun 2.

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.

Objective: Rituximab (RTX) has important usage in rheumatoid arthritis and vasculitis. There remains a need for more, better, and safer treatments for patients with lupus nephritis (LN). RTX has been trialed in such patients without definitive conclusions about its effectiveness. Read More

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http://dx.doi.org/10.1177/0961203320928412DOI Listing

Long-term Outcomes of MCP Surface Replacement Arthroplasty in Patients With Rheumatoid Arthritis.

Hand (N Y) 2020 Jun 2:1558944720926631. Epub 2020 Jun 2.

Mayo Clinic, Rochester, MN, USA.

Surface replacement arthroplasty (SRA) can be used in the treatment of rheumatoid arthritis (RA) affecting the metacarpophalangeal (MCP) joint. The authors of this study sought to investigate the outcomes of MCP SRA in patients with RA. Retrospective review of medical records and an institutional joint registry were used to gather data on 80 MCP SRAs performed in 27 patients with RA. Read More

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http://dx.doi.org/10.1177/1558944720926631DOI Listing

[Recommendations of diagnosis and treatment of gout in China].

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):421-426

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China.

Gout is a crystal associated arthritis caused by monosodium urate (MSU) accumulating in joint, and it belongs to metabolic rheumatic disease. In China, gout is common but it is insufficient for education of standardized diagnosis and treatment for gout. Based on the evidence and guidelines from China and other countries, Chinese gout Collaborative Research Group developed standardization of diagnosis and treatment of gout in China. Read More

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http://dx.doi.org/10.3760/cma.j.cn112138-20200327-00306DOI Listing

Identification of Novel Native Autoantigens in Rheumatoid Arthritis.

Biomedicines 2020 May 29;8(6). Epub 2020 May 29.

Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.

The majority of patients diagnosed with rheumatoid arthritis (RA) have developed autoantibodies against neoepitopes in proteins that have undergone post-translational modification, e.g., citrullination or carbamylation. Read More

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http://dx.doi.org/10.3390/biomedicines8060141DOI Listing

Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Metabolites 2020 May 29;10(6). Epub 2020 May 29.

Departments of Orthopaedic Surgery and Research, Beaumont Health, Royal Oak, MI 48073, USA.

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism has been implicated in disease development, both locally and systemically. Read More

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http://dx.doi.org/10.3390/metabo10060223DOI Listing

Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks.

Bone 2020 May 30:115461. Epub 2020 May 30.

Arthritis Program, University Health Network, Toronto, Ontario, Canada; Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. Electronic address:

Osteoarthritis (OA) is a debilitating disease with no effective disease-modifying therapies. Among the challenges for developing treatment is achieving targeted drug delivery to affected joints. This has contributed to the failure of several drug candidates for the treatment of OA. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115461DOI Listing

IL-21 CD4 T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis.

Clin Immunol 2020 May 30:108484. Epub 2020 May 30.

Pediatric Immunology, , Department of Pediatrics, University of Würzburg, Germany; Pediatric Rheumatology, Department of Pediatrics, University of Würzburg, Germany. Electronic address:

Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups. Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a clinically homogenous new subgroup. CD4 T helper (Th) cells play an essential role in JIA pathogenesis. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108484DOI Listing