169,677 results match your criteria Arteriosclerosis and Thrombosis[Journal]


The intervention of enalapril maleate and folic acid tablet on the expressions of the GRP78 and CHOP and vascular remodeling in the vascular smooth muscle cells of H-hypertensive rats with homocysteine.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7985-7993

Department of Vascular Surgery, Jining No.1 People's Hospital, Jining, Shandong Province, China.

Objective: Lower extremity arteriosclerosis is one of leading causes of death worldwide. Arteriosclerosis is closely related to microvascular endothelial cells. This study was aimed to explore the role of long non-coding RNA ROR in regulations of growth, migration, and angiogenesis of microvascular endothelial cells. Read More

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November 2018

Variations on classification of main types of myocardial infarction: a systematic review and outcome meta-analysis.

Clin Res Cardiol 2018 Dec 7. Epub 2018 Dec 7.

3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, Vienna, Austria.

Objective: Classifying myocardial infarction into type 1 (T1MI) or type 2 (T2MI) remains a challenge in clinical practice. We aimed to identify factors contributing to variation in the classifications of MI into type 1 or type 2. In addition, pooled analyses of long-term mortality and reinfarction outcomes were performed. Read More

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December 2018
1 Read

Side effects of frequently used oral antidiabetics on wound healing in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453, Witten, Germany.

Lifestyle diseases such as diabetes and arteriosclerosis are rising in the increasingly aging society, and the number of patients with daily intake of glucose-lowering medication has also increased. Interestingly, knowledge about oral antidiabetics with regard to wound healing is scarce. Therefore, the aim of this study was to identify possible (side) effects of the most frequently prescribed oral antidiabetics on skin cells and wound healing. Read More

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December 2018
1 Read

Effects of regular high-cocoa chocolate intake on arterial stiffness and metabolic characteristics during exercise.

Nutrition 2018 Oct 5;60:53-58. Epub 2018 Oct 5.

Faculty of Environmental Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.

Objective: The aim of this study was to examine the effects of regular high-cocoa chocolate consumption on arterial stiffness and fat oxidation during light- to moderate-intensity exercise.

Methods: This randomized, controlled, parallel-group intervention study included 32 Japanese college students (mean age, 20.7 ± 0. Read More

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October 2018

Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification.

J Stroke Cerebrovasc Dis 2018 Dec 8. Epub 2018 Dec 8.

Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background And Purpose: Elevated serum aldosterone concentration is known to be linked with elevated risk of cerebrovascular events as a result of vascular senescence. We studied the association between serum aldosterone concentration and cerebral arteriosclerosis status involving cerebral atherosclerosis burden and cerebral vascular calcification.

Methods: A total of 207 patients (mean age = 62. Read More

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December 2018

Pathophisiology of abdominal aortic aneurysm: biomarkers and novel therapeutic targets.

Clin Investig Arterioscler 2018 Dec 6. Epub 2018 Dec 6.

CIBER de Enfermedades Cardiovasculares (CIBERCV), España; Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, España. Electronic address:

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease, usually asymptomatic, there is a progressive dilatation of the vascular wall that can lead to its rupture, a fatal phenomenon in more than 80% of cases. The treatment of patients with asymptomatic aneurysms is limited to periodic monitoring with imaging tests, control of cardiovascular risk factors and treatment with statins and antiplatelet therapy. Read More

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December 2018

[Exploration of thrombus histological composition and clinical effect in mechanical thrombectomy of acute ischemic stroke].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3697-3700

Department of Neurosurgery, the First People's Hospital of Changzhou, the Third Affilated Hospital of Soochow University, Changzhou 213003, China.

To explore histological composition of thrombus and clinical effect in mechanical thrombectomy of acute ischemic stroke. From March 2017 to August 2017 at the Institutes of Biology and Medical Sciences of Soochow University, hematoxylin and eosin (HE) staining was used to quantitatively analyze the composition of thrombus in 58 cases with acute ischemic stroke. The differences in components of thrombus with different TOAST classifications were compared, meanwhile, clinical data such as surgical process and prognosis were also analyzed. Read More

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December 2018

Hydrogen peroxide constricts rat arteries by activating Na-permeable and Ca-permeable cation channels.

Free Radic Res 2018 Dec 10:1-171. Epub 2018 Dec 10.

b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.

Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More

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December 2018

Bilateral internal thoracic artery grafting: or composite?

Ann Cardiothorac Surg 2018 Sep;7(5):673-680

Department of Cardiac Surgery, Ottawa Heart Institute, Ottawa, Canada.

Bilateral internal thoracic artery (BITA) grafting is considered a superior choice for coronary artery bypass grafting (CABG). While the 10-year outcomes of BITA grafting from the recent Arterial Revascularization Trial (ART) are still pending, numerous observational studies have demonstrated the advantages of BITA grafting. These include better long-term graft patency and freedom from arteriosclerosis, in addition to higher survival rate compared to CABG using only the left internal thoracic artery (ITA). Read More

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September 2018

ANGPTL3 Inhibitors - Their Role in Cardiovascular Disease Through Regulation of Lipid Metabolism.

Circ J 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, Evangelismos General Hospital.

Elevated plasma lipid levels are linked to atherosclerosis, a hallmark for coronary artery disease (CAD), documented by animal studies as well as angiographic and clinical studies. The ability to treat hyperlipidemia through lifestyle changes and lipid-lowering agents has been related to the slow progression of atherosclerosis and decreased incidence of major coronary events. Angiopoietin-like proteins (ANGPTLs) are a family of secreted glycoproteins expressed in the liver that share common domain characteristics with angiopoietins, the main regulators of angiogenesis. Read More

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November 2018

Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study.

Maturitas 2019 Jan 11;119:39-45. Epub 2018 Nov 11.

Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oonohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. Electronic address:

Objective: Only a few longitudinal studies have assessed the relationship between bone mineral density (BMD) and arteriosclerosis. This study aimed to determine whether low BMD at baseline is associated with the development of increased arterial stiffness, as evaluated by brachial-ankle pulse wave velocity (baPWV), in Japanese women.

Methods: A baPWV value of ≥1800 cm/s was adopted as the criterion for increased arterial stiffness, i. Read More

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January 2019

Subclinical parameters of arterial stiffness and arteriosclerosis correlate with QRISK3 in systemic lupus erythematosus.

PLoS One 2018 5;13(12):e0207520. Epub 2018 Dec 5.

Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Instituto de Terapéutica Experimental y Clínica (INTEC), Guadalajara, Jalisco, México.

It is well known that cardiovascular diseases (CVD) are a major contributor of death in systemic lupus erythematosus (SLE) as well in other rheumatic illness. In the last decades, there has been a growing development of different methodologies with the purpose of early detection of CVD.

Objective: The aim of this study is to correlate the usefulness of subclinical parameters of vascular aging and QRISK 3-2017 score for early detection of CVD in SLE. Read More

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December 2018
1 Read

Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetic patients with diabetic nephropathy.

J Diabetes Investig 2018 Dec 5. Epub 2018 Dec 5.

Division of Nephrology, Kanazawa University Hospital, Kanazawa, Japan.

Aims/introduction: This retrospective study investigated the impact of renal arteriosclerosis (AS) and hypertension (HT) on long-term renal and cardiovascular outcomes in Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy.

Materials And Methods: A total of 185 patients were enrolled. Patients were divided into four groups stratified by renal AS status and presence of HT. Read More

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December 2018
8 Reads

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Read More

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December 2018
1 Read

Correlations of soluble osteoclast-associated receptor (sOSCAR) with acute coronary syndrome.

Ann Transl Med 2018 Oct;6(20):408

Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.

Background: An osteoclast-associated receptor (OSCAR) is an immunoglobulin receptor expressed in an osteoclast, and takes part in the formation of an osteoclast. While the soluble OSCAR (sOSCAR) component is reported to be involved in the pathogenesis of arteriosclerosis, the aim of this present study is to investigate the relationship between sOSCAR and acute coronary syndrome (ACS).

Methods: This study enrolled 41 patients with ACS and 33 patients without ACS as a control, from March 2017 to June 2017. Read More

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October 2018

Brachial-ankle pulse wave velocity, cardio-ankle vascular index, and prognosis.

Authors:
Dai Ato

Vasc Health Risk Manag 2018 24;14:321-348. Epub 2018 Oct 24.

Gakujutsu Shien Co., Ltd, Tokyo, Japan,

Background: Brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are indices of arterial stiffness, and several studies have used these indices. However, there is no comprehensive review of these parameters in the prognostic significance.

Methods: The aim of this study was to review the articles exploring the prognostic significance of these parameters. Read More

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October 2018
1 Read

The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus.

J Atheroscler Thromb 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

Aims: This study elucidates the association of macroangiopathy development in type 2 diabetes patients with various arteriosclerosis risk factors (ARFs) and results of cardio-ankle vascular index (CAVI) and ankle-brachial pressure index (ABI).

Methods: The correlation between current and past macroangiopathy development, with ARFs or CAVI/ABI data, was retrospectively analyzed using multivariate logistic regression in 816 patients with type 2 diabetes at a single center. C-statistics combining some independent variables selected using the stepwise method were evaluated. Read More

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November 2018
3 Reads

Pregnancy-associated plasma protein-a is associated with subclinical atherosclerosis in men with HIV infection.

J Investig Med 2018 Nov 28. Epub 2018 Nov 28.

Cardiology, University of Health Science, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

The pathophysiology of an early and accelerated atherosclerotic process is complex and multifactorial in HIV-infected men compared with HIV-non-infected men. Several biomarkers have been well studied in the detection of the early stage of atherosclerosis, but studies are limited in HIV-infected men. The objective of this study was to investigate the association between serum pregnancy-associated plasma protein-A (PAPP-A) and carotid intima-media wall thickness (CIMT) in asymptomatic HIV-infected men. Read More

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November 2018

[Ferroptosis pathway and its intervention regulated by Chinese materia medica].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4019-4026

Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Ferroptosis is a new form of regulated cell death which is different from apoptosis, necrosis and autophagy, and results from iron-dependent lipidperoxide accumulation. Now, it is found that ferroptosis is involved in multiple physiological and pathological processes, such as cancer, arteriosclerosis, neurodegenerative diseases, diabetes, antiviral immune response, acute renal failure, hepatic and heart ischemia/reperfusion injury. On the one hand, it could be found the appropriate drugs to promote ferroptosis to clear cancer cells and virus infected cells, etc. Read More

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October 2018
4 Reads

Chronic kidney cortical damage is associated with baseline kidney function and albuminuria in patients managed with radical nephrectomy for kidney tumours.

Pathology 2018 Nov 23. Epub 2018 Nov 23.

Princess Alexandra Hospital, Brisbane, Qld, Australia; Centre for Kidney Disease Research, University of Queensland, Brisbane, Qld, Australia; Translational Research Institute, Brisbane, Qld, Australia.

This study evaluated the relationship between histological markers of chronic kidney damage in patients undergoing radical nephrectomy for kidney tumours and preoperative kidney function, degree of albuminuria, and changes in glomerular volume. A schema to grade chronic kidney damage could be used to identify patients at risk of developing CKD following nephrectomy. Non-neoplastic cortical tissue was sourced from 150 patients undergoing radical nephrectomy for suspected kidney cancer. Read More

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November 2018
11 Reads

Evaluation of Risk Factors for Limb-Specific Peripheral Vascular Events in Patients With Peripheral Artery Disease: A Post Hoc Analysis of the SEASON Prospective Observational Study.

Angiology 2018 Nov 26:3319718814351. Epub 2018 Nov 26.

7 Mitsubishi Tanabe Pharma Corporation, Osaka, Japan.

Surveillance of cardiovascular Events in Antiplatelet-treated arterioSclerosis Obliterans patients in JapaN (SEASON) is a 2-year, prospective, real-world, registry study conducted in Japan from 2009 to 2013. This post hoc analysis evaluated risk factors for limb ischemia in patients with peripheral arterial disease (PAD) and ankle-brachial index (ABI) <0.90. Read More

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November 2018
3 Reads

Excess Weight in Spain: Current Situation, Projections for 2030, and Estimated Direct Extra Cost for the Spanish Health System.

Rev Esp Cardiol (Engl Ed) 2018 Nov 23. Epub 2018 Nov 23.

Grupo de investigación REGICOR, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Introduction And Objectives: Excess weight promotes the development of several chronic diseases and decreases quality of life. Its prevalence is increasing globally. Our aim was to estimate the trend in excess weight between 1987 and 2014 in Spanish adults, calculate cases of excess weight and its direct extra costs in 2006 and 2016, and project its trend to 2030. Read More

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November 2018
1 Read

AIP1 suppresses transplant arteriosclerosis through inhibition of vascular smooth muscle cell inflammatory response to IFNγ.

Anat Rec (Hoboken) 2018 Nov 24. Epub 2018 Nov 24.

Department of Vascular Surgery, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, China.

IFNγ-induced vascular smooth muscle cells (VSMCs) inflammatory response plays a key role in transplant arteriosclerosis (TA). However, the mechanisms regulating this process remains poorly defined. Here we show that ASK1-interacting protein 1 (AIP1) deletion markedly augments the expression of IFNγ-induced chemokines in mouse aortic allografts. Read More

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November 2018
1 Read

COSMIC project: consensus on the objectives of the metabolic syndrome in clinic.

Diabetes Metab Syndr Obes 2018 31;11:683-697. Epub 2018 Oct 31.

Internal Medicine Service, Department of Medicine and Dermatology, Hospital Universitario Virgen de la Victoria, Málaga Biomedicine Institute (IBIMA), Universidad de Málaga, Málaga, Spain.

Metabolic syndrome (MetS), a disorder with a high and growing prevalence, is a recognized risk factor for cardiovascular disease (CVD) and type 2 diabetes. It is a constellation of clinical and metabolic risk factors that include abdominal obesity, dyslipidemia, glucose intolerance, and hypertension. Unfortunately, MetS is typically underrecognized, and there is great heterogeneity in its management, which can hamper clinical decision-making and be a barrier to achieving the therapeutic goals of CVD and diabetes prevention. Read More

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October 2018
3 Reads

Is FGF-23 an early indicator of atherosclerosis and cardiac dysfunction in patients with gestational diabetes?

Arch Endocrinol Metab 2018 Oct;62(5):506-513

Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.

Objective: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone and plays a role in the pathogenesis of myocardial hypertrophy. The aim of this study was to evaluate the association of FGF-23 levels with echocardiographic parameters and insulin resistance (IR) in patients with gestational diabetes.

Subjects And Methods: Fifty-four pregnant patients with gestational diabetes mellitus (GDM) (age, 31. Read More

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October 2018
2 Reads

The Klotho proteins in health and disease.

Authors:
Makoto Kuro-O

Nat Rev Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho-FGFR4 complex in hepatocytes to promote metabolic responses to feeding. Read More

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November 2018
8 Reads

Calcium Scoring for Cardiovascular Computed Tomography: How, When and Why?

Radiol Clin North Am 2019 Jan;57(1):1-12

Departments of Radiology, Biomedical Informatics, and Cardiovascular Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 300-B, Nashville, TN 37203-8281, USA. Electronic address:

Cardiovascular disease is the leading cause of death in the United States and worldwide. Despite major advances in the treatment of acute myocardial infarction, enhanced prevention of ischemic heart disease remains critical to improving the health of individuals and communities. The computed tomographic coronary artery calcium score is an established imaging biomarker that identifies the presence and amount of coronary atherosclerosis in an individual and their future risk for clinical cardiovascular disease and premature cardiovascular death. Read More

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January 2019
1 Read

A high titer of acquired factor V inhibitor in a hemodialysis patient who developed arterial thrombosis.

Int J Hematol 2018 Nov 16. Epub 2018 Nov 16.

Japanese Collaborative Research Group on Autoimmune Coagulation Factor Deficiencies (JCRG supported by the Japanese Ministry of Health, Labor and Welfare), Yamagata, Japan.

An 87-year-old man with diabetes mellitus was admitted to control recurrent bleeding from hemodialysis puncture sites. He was a smoker and had been diagnosed with arteriosclerosis obliterans. His PT and APTT were markedly prolonged, and all coagulation factors were markedly decreased (factor V [FV] activity < 1%) or below the measurement threshold, with the exception of fibrinogen and factor XIII. Read More

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November 2018
5 Reads

Association between vertebral artery hypoplasia and vertebral artery aneurysms: A case-control study.

J Clin Neurosci 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurosurgery, Juha Hernesniemi International Center, Henan Province People's Hospital, Zhengzhou, China.

Background: The aim of this retrospective case-control study is to determine the association of vertebral artery hypoplasia (VAH) and other anatomical variants with saccular vertebral artery posterior inferior cerebellar artery (VA-PICA) aneurysms.

Methods: The prevalence of VAH, vertebral artery (VA) atresia, VA aplasia, and PICA aplasia was analyzed using CT angiography in 64 patients with VA-PICA aneurysms (43 ruptured and 21 unruptured) and compared to 128 age- and sex-matched controls. Logistic regression was performed to identify independent risk factors for aneurysm formation. Read More

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November 2018
1.320 Impact Factor

Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.

Sci Rep 2018 Nov 14;8(1):16822. Epub 2018 Nov 14.

Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Read More

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November 2018
21 Reads

Coronary Artery Calcium Scoring: Current Status and Review of Literature.

J Comput Assist Tomogr 2018 Nov/Dec;42(6):887-897

From the Johns Hopkins Hospital, Baltimore, MD.

Coronary artery calcium is a marker of overall atherosclerotic plaque burden, corresponding to approximately 20% overall atherosclerotic plaque burden. Coronary artery calcium screening, most commonly performed using the Agatston score, has been shown to be a predictor of future cardiovascular risk independent of conventional risk scores such as the Framingham risk score. Coronary artery calcium screening is also recommended on routine nongated, noncontrast chest computed tomography scans using several ordinal and visual scoring systems. Read More

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November 2018
2 Reads

Alprostadil treatment of critical limb ischemia in hemodialysis patients : A retrospective single-center analysis.

Wien Klin Wochenschr 2018 Nov 12. Epub 2018 Nov 12.

Department of Internal Medicine 3, Academic Teaching Hospital Feldkirch, Carinagasse 47, 6800, Feldkirch, Austria.

Background: Peripheral artery disease and critical limb ischemia are common in patients undergoing chronic hemodialysis treatment and are associated with a high rate of amputation and mortality. The effect of treatment with prostanoids in this specific group of patients is unknown.

Methods: A retrospective single-center analysis of hemodialysis patients with critical limb ischemia was performed who were treated with the prostanoid analogue alprostadil as an infusion during hemodialysis in the period from 2000 to 2013. Read More

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November 2018
2 Reads

Pediatric reference values for arterial stiffness parameters cardio-ankle vascular index and CAVI.

J Am Soc Hypertens 2018 Nov 22;12(11):e35-e43. Epub 2018 Oct 22.

Department of Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic; Biomedical Center Martin, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.

The process of arteriosclerosis begins early in life, and cardiovascular risk factors identified in childhood tend to persist into adulthood. Cardio-ankle vascular index (CAVI), a recent parameter of arterial stiffness, is considered an independent predictor of cardiovascular risk. However, there are no studies reporting sex- and age-specific physiological values of CAVI in childhood. Read More

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November 2018

Holding Eternity in one's hand: First three-dimensional reconstruction and printing of the heart from 2700 years-old Egyptian mummy.

Anat Rec (Hoboken) 2018 Nov 12. Epub 2018 Nov 12.

Department of medical imaging, Cliniques universitaires saint Luc, Université catholique de Louvain, Av. Hippocrate 10, 1200 Brussels, Belgium.

The heart in ancient Egyptian mummification procedure is the central organ that should stay in place in the chest and waiting for the afterlife judgment. Here we show the first case of three-dimensional (3D) CT scan reconstruction of a mummified heart from a person embalmed in Egypt around 2,700 years ago, and present a 3D printing of the same heart using a low-cost yet accurate 3D printer. A multi-slice computed tomography scanner was used to scan the mummy. Read More

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November 2018
4 Reads

A review of the anti-inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes.

J Cell Physiol 2018 Nov 11. Epub 2018 Nov 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The global prevalence of Type 2 diabetes mellitus and its associated complications are growing rapidly. Although the role of hyperglycemia is well recognized in the pathophysiology of diabetic complications, its exact underlying mechanisms are not fully understood. In this regard, accumulating evidence suggests that the role of inflammation appears pivotal, with studies showing that most diabetic complications are associated with an inflammatory response. Read More

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November 2018
2 Reads
3.840 Impact Factor

First-in-Man Clinical Pilot Study Showing the Safety and Efficacy of Intramuscular Injection of Basic Fibroblast Growth Factor With Atelocollagen Solution for Critical Limb Ischemia.

Circ J 2018 Nov 9. Epub 2018 Nov 9.

Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

Background: Therapeutic angiogenesis with basic fibroblast growth factor (bFGF) with atelocollagen was confirmed in a study using a limb ischemia mouse model. Because the number of elderly patients with critical limb ischemia (CLI) is increasing, particularly that caused by arteriosclerosis obliterans (ASO), the development of less invasive angiogenesis therapies desired. Methods and Results: This first-in-man clinical study was designed to assess the safety and efficacy of i. Read More

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November 2018

Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models.

Life Sci 2018 Nov 7. Epub 2018 Nov 7.

Department of the Second Anesthesiology, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Inflammation is the vital defensive response triggered by our immune system against an infection or deleterious stimuli. This response in due course affects its own biological system leading to serious diseases like arteriosclerosis, osteoporosis, pancreatitis, cancer etc. Currently, researchers focused on utilizing phytochemicals as anti-inflammatory drugs since the drugs presently available in the market causes serious side effects and are less potent. Read More

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November 2018
5 Reads
2.700 Impact Factor

Branch ostial optimization treatment and optimized provisional t-stenting with polymeric bioresorbable scaffolds: Ex-vivo morphologic and hemodynamic examination.

Medicine (Baltimore) 2018 Oct;97(43):e12972

Department of Cardiology, Fujian Medical University Union Hospital.

The optimal side-branch (SB) ostium treatment after provisional side-branch scaffolding remains a subject of debate in bioresorbable vascular scaffold (BVS) era. In this study, we evaluated a novel optimized provisional T-stenting technique (OPT) and assessed its feasibility by comparison with T and small protrusion technique (TAP).Two provisional SB scaffolding techniques (OPT, n = 5; TAP, n = 5) were performed using polymeric BVS in a bifurcated phantom. Read More

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October 2018
5 Reads

Association of lymphocyte to monocyte ratio with severity of coronary artery disease.

Medicine (Baltimore) 2018 Oct;97(43):e12813

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health.

The aim of this study was to investigate the relationship between lymphocyte to monocyte ratio (LMR) and the severity of coronary artery disease (CAD) by using Gensini score.A total of 199 patients, who had undergone coronary angiography, were included in the study and retrospectively analyzed. Among them, 49 patients who had normal coronary arteries were selected as the control group. Read More

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October 2018
3 Reads
5.720 Impact Factor

Unprotected versus protected high-risk percutaneous coronary intervention with the Impella 2.5 in patients with multivessel disease and severely reduced left ventricular function.

Medicine (Baltimore) 2018 Oct;97(43):e12665

First Department of Medicine-Cardiology, University Medical Centre Mannheim.

Selecting a revascularization strategy in patients with multivessel disease (MVD) and severely reduced left ventricular ejection fraction (LVEF) remains a challenge. PCI with Impella 2.5 may facilitate high-risk PCI, however long-term results comparing unprotected versus protected PCI are currently unknown. Read More

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October 2018
10 Reads

Coronary artery aneurysm formation after drug-coated balloon treatment of de novo lesions: Two case reports.

Medicine (Baltimore) 2018 Nov;97(45):e13208

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China.

Rationale: The safety and efficacy of drug-coated balloon (DCB) technology have primarily been proven in the treatment of coronary in-stent restenosis. Whereas increasing evidences show that DCB use was feasible in certain de novo coronary lesions. In 2012, Vassilev reported the 1st case in which a coronary aneurysm formed after a DCB was used to treat drug-eluting stent (DES) restenosis. Read More

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November 2018
6 Reads

Assessing the Relationship Between American Heart Association Atherosclerotic Cardiovascular Disease Risk Score and Coronary Artery Imaging Findings.

J Comput Assist Tomogr 2018 Nov/Dec;42(6):898-905

Department of Medicine, Stanford University School of Medicine.

Objective: The aim of this study was to characterize the relationship between computed tomography angiography imaging characteristics of coronary artery and atherosclerotic cardiovascular disease (ASCVD) score.

Methods: We retrospectively identified all patients who underwent a coronary computed tomography angiography at our institution from December 2013 to July 2016, then we calculated the 10-year ASCVD score. We characterized the relationship between coronary artery imaging findings and ASCVD risk score. Read More

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November 2018
13 Reads
1.600 Impact Factor

Cardiac Allograft Vasculopathy - Heart Transplantation Provides Insights Into Pathogenesis and Treatment of Arteriosclerosis.

Authors:
Shinichi Nunoda

Circ J 2018 Nov 6;82(12):2943-2945. Epub 2018 Nov 6.

Department of Therapeutic Strategy for Severe Heart Failure, Graduate School of Medicine, Tokyo Women's Medical University.

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November 2018
2 Reads

In vivo detection of chronic kidney disease using tissue deformation fields from dynamic MR imaging.

IEEE Trans Biomed Eng 2018 Nov 2. Epub 2018 Nov 2.

Objective: Chronic kidney disease (CKD) is a serious medical condition characterized by gradual loss of kidney function. Early detection and diagnosis is mandatory for adequate therapy and prognostic improvement. Hence, in the current pilot study we explore the use of image registration methods for detecting renal morphologic changes in patients with CKD. Read More

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November 2018
1 Read

Role of GSPE in improving early cerebral vascular damage by inhibition of Profilin-1 expression in a ouabain-induced hypertension model.

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6999-7012

Department of Respiratory, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Objective: Grape seed proanthocyanidin extract (GSPE), as one of the most popular natural drug extracted from the grape, has been reported to improve endothelial function and arteriosclerosis. However, little is known about the influence of GSPE on hypertension and vascular remodeling. Profilin-1, an Actin-binding protein, is closely involved in the remodeling of large vessels in ouabain-induced hypertension. Read More

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October 2018
4 Reads

HOXA11-AS regulates diabetic arteriosclerosis-related inflammation via PI3K/AKT pathway.

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6912-6921

Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.

Objective: This study aims to explore whether homeobox A11 antisense RNA (HOXA11-AS) could regulate inflammation induced by diabetic arteriosclerosis (DAA) via PI3K/AKT pathway.

Patients And Methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect expressions of HOXA11-AS and proinflammatory genes in carotid endarterectomy samples of symptomatic and asymptomatic atherosclerosis (AS) patients, diabetes mellitus (DM), and non-DM patients. The above-mentioned genes in DM animal model and non-DM animal model were also detected. Read More

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October 2018
3 Reads

2015 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report.

Ann Vasc Dis 2018 Sep;11(3):398-426

Since 2013, the Japanese Society for Vascular Surgery has started the project of nationwide registration and tracking database for patients with critical limb ischemia (CLI) who are treated by vascular surgeons. The purpose of this project is to clarify the current status of the medical practice for the patients with CLI to contribute to the improvement of the quality of medical care. This database, called JAPAN Critical Limb Ischemia Database (JCLIMB), was created on the National Clinical Database and collects data of patients' background, therapeutic measures, early results, and long term prognosis as long as five years after the initial treatment. Read More

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September 2018

Numerical study on the impulsive growth of a gaseous plug inside a cylindrical vein with compliant coating.

Bioimpacts 2018 18;8(4):271-279. Epub 2017 Sep 18.

School of Mechanical Engineering, University of Tabriz, Tabriz, Iran.

: Employing of gaseous plugs inside a vein for preventing of blood flow to the damaged or cancerous tissues has been known as a gas embolism in the medicine. In this research, a numerical investigation has been carried out on the delivery of the liquid drug DDFP, encapsulated in the microlipidcoated spheres (MLCSs), to target the human vein for construction of the gaseous plug inside the veins. : The encapsulated liquid drug DDFP were delivered to the vein by injection of an emulsion. Read More

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September 2017

Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.

Life Sci 2018 Dec 28;214:41-50. Epub 2018 Oct 28.

Heart Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750001, China; Institute of Cardiovascular Diseases, General Hospital of Ningxia Medical University Yinchuan, Ningxia 750001, China. Electronic address:

Aims: Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LXRα induced by Hcy in macrophages is still unknown. The present study aimed to investigate the potential role of Hcy in disordered lipid metabolism and atherosclerotic lesions, especially the effects of Hcy on cholesterol efflux in macrophages and the possible mechanisms. Read More

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December 2018

Long Noncoding RNAs in Atherosclerosis: JACC Review Topic of the Week.

J Am Coll Cardiol 2018 Nov;72(19):2380-2390

Division of Cardiology, Department of Medicine, University of California, Los Angeles, California; and the Molecular Biology Institute, University of California, Los Angeles, California. Electronic address:

Atherosclerosis is a complex and chronic disease characterized by lipid deposition in the vessel wall that leads to an inflammatory and proliferative cascade involving smooth muscle, endothelial, and immune cells. Despite substantial improvements in our understanding of mechanisms contributing to atherosclerosis and overall reduction in cardiovascular mortality, the absolute disease burden remains substantially high. The recent discovery of a new group of mediators known as long noncoding ribonucleic acids (lncRNAs) offers a unique opportunity for the development of novel diagnostic and therapeutic tools in atherothrombotic disease. Read More

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November 2018
2 Reads