170,933 results match your criteria Arteriosclerosis Thrombosis and Vascular Biology[Journal]


Characteristics of visit-to-visit blood pressure variability in hemodialysis patients.

Hypertens Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.

Visit-to-visit blood pressure variability (VVBPV) is an independent risk factor for cardiovascular morbidity and mortality in the general population. Hemodialysis (HD) patients have a poor prognosis due to an increased prevalence of cardiovascular disease. Intradialytic hypotension is associated with excess mortality, but whether VVBPV influences mortality is still unclear in HD patients. Read More

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http://dx.doi.org/10.1038/s41440-019-0231-9DOI Listing
February 2019

Absolute risk score for stroke, myocardial infarction, and all cardiovascular disease: Japan Arteriosclerosis Longitudinal Study.

Hypertens Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Integrated Science and Engineering for Sustainable Society, Faculty of Science and Engineering, Chuo University, Tokyo, Japan.

To develop a risk chart or score that is based on recent data and applicable to the Japanese people, we need a large cohort study representative of the Japanese people without a need for long-term follow-up. The purpose of the present study was to develop a risk scoring system to estimate the 5- and 10-year absolute and cumulative incidence risk of stroke and acute myocardial infarction (AMI), composite outcome of stroke and AMI, and death from all cardiovascular disease (CVD). The cumulative incidence risk ratios were calculated using a multiple Poisson regression model and data from the Japan Arteriosclerosis Longitudinal Study, which included 67,969 men and women aged 40-89 years. Read More

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http://dx.doi.org/10.1038/s41440-019-0220-zDOI Listing
February 2019

Bilateral cerebral infarction associated with severe arteriosclerosis in the A1 segment: a case report.

J Int Med Res 2019 Feb 14:300060519828930. Epub 2019 Feb 14.

1 Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Large artery atherosclerosis and cardioembolism are the two major subtypes of ischemic stroke. We herein describe a 75-year-old man with acute complete cerebral infarction in the typical territories of the bilateral anterior cerebral artery (ACA) and left middle cerebral artery. Brain magnetic resonance angiography showed that the right A1 segment of the ACA was affected by severe arteriosclerosis and that the right ACA other than the A1 segment was compensated by the left ACA through the anterior communicating artery. Read More

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http://dx.doi.org/10.1177/0300060519828930DOI Listing
February 2019

Low Back Pain: A Pain That May Not Be Harmless.

Eur J Case Rep Intern Med 2018 21;5(3):000834. Epub 2018 Mar 21.

Serviço de Medicina Interna B, Hospital Geral, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Abdominal aortic aneurysms are defined as vascular dilatations greater than 50% of the normal proximal segment or those that have a maximum diameter above 3 cm. Risk factors include male gender, age over 75 years, history of vascular pathology, hypertension and arteriosclerosis. The Authors describe a case of a 74-year-old man, evaluated in an emergency setting for right lumbar pain lasting 4 days. Read More

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http://dx.doi.org/10.12890/2018_000834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346959PMC

Treatment of a high cardiovascular risk patient with McArdle's disease with PCSK9 inhibitors.

Clin Investig Arterioscler 2019 Feb 6. Epub 2019 Feb 6.

Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, IIS Aragón, CIBERCV, Zaragoza, España; Universidad de Zaragoza, Zaragoza, España.

A 60-year-old male with familial combined hyperlipidemia, ischemic heart disease and type 2 diabetes. Since childhood, intolerance to intense exercise. The patient was diagnosed of McArdle's disease after an episode of rhabdomyolysis associated with statins as treatment after a myocardial infarction. Read More

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http://dx.doi.org/10.1016/j.arteri.2018.11.005DOI Listing
February 2019

Gut microbiota: A new protagonist in the risk of cardiovascular disease?

Clin Investig Arterioscler 2019 Feb 5. Epub 2019 Feb 5.

Unidad de Lípidos y Arteriosclerosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, España.

Cardiovascular disease remains the first cause of mortality in Western countries. New strategies for prevention and control of cardiovascular disease are needed. At the same time, the incidence of risk factors that lead to the development of this disease, such as obesity, hypertension and diabetes, continues to rise. Read More

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http://dx.doi.org/10.1016/j.arteri.2018.11.003DOI Listing
February 2019
1 Read

Hospital Discharge Teaching for Patients with Peripheral Vascular Disease.

Crit Care Nurs Clin North Am 2019 Mar 22;31(1):91-95. Epub 2018 Dec 22.

Louisiana State University Health New Orleans, School of Nursing, 1900 Gravier Street, New Orleans, LA 70112, USA.

Peripheral disease affects both arteries and veins and encompasses pathophysiologic conditions that affect arterial, venous, and lymphatic circulations. This article discusses disorders of peripheral vascular disease (PVD) that affect the lower extremity. PVD is an obstruction in the arteries known as arteriosclerosis obliterans, a condition that manifests from insufficient tissue perfusion that results in hardening of the arteries. Read More

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http://dx.doi.org/10.1016/j.cnc.2018.11.003DOI Listing

In times of tobacco-free nicotine consumption: The influence of nicotine on vascular calcification.

Eur J Clin Invest 2019 Feb 5:e13077. Epub 2019 Feb 5.

Charité - Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology, Campus Benjamin Franklin, Berlin, Germany.

Background: Smoking remains the most important avoidable cause of global mortality. Even though the number of cigarette smokers declines in first world countries, the uses of alternative nicotine delivery products increase and may even surpass the sells of cigarettes. In this light, the explicit role of nicotine in the development of cardiovascular diseases should be elucidated. Read More

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http://dx.doi.org/10.1111/eci.13077DOI Listing
February 2019

Correlation of systemic arterial stiffness with changes in retinal and choroidal microvasculature in type 2 diabetes.

Sci Rep 2019 Feb 4;9(1):1401. Epub 2019 Feb 4.

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

This study was conducted to assess whether systemic arterial stiffness, indicated by cardio-ankle vascular index (CAVI), is related to changes in the microvasculature of the retina and choroid in diabetes mellitus (DM). This study included 113 patients with a confirmed diagnosis of type-2 DM. Among them, 18 patients did not have diabetic retinopathy (DR), 71 had non-proliferative DR (NPDR), and 24 had proliferative DR (PDR). Read More

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http://dx.doi.org/10.1038/s41598-018-37969-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361886PMC
February 2019

"18FDG PET/CT & Arterial Inflammation: Predicting Cardiovascular Events in Lung Cancer".

QJM 2019 Feb 2. Epub 2019 Feb 2.

Internal Medicine, Hospital Clínico Universitario Virgen de la Victoria, Department of Medicine and Dermatology (IBIMA), University of Malaga, Málaga, Spain.

18F-FDG PET/CT predicst cardiovascular disease. To analyze the predictive value of cardiovascular events from inflammation and arterial calcification in patients who underwent an 18F-FDG PET/CT for lung cancer. A retrospective study of 274 patients with primary lung neoplasia. Read More

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http://dx.doi.org/10.1093/qjmed/hcz036DOI Listing
February 2019

Potential Role of H-Ferritin in Mitigating Valvular Mineralization.

Arterioscler Thromb Vasc Biol 2019 Jan 31:ATVBAHA118312191. Epub 2019 Jan 31.

From the HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian, Academy of Sciences, Debrecen (K.É.S., L.P., M.O., N.P., G.B., J.B.).

Objective- Calcific aortic valve disease is a prominent finding in elderly and in patients with chronic kidney disease. We investigated the potential role of iron metabolism in the pathogenesis of calcific aortic valve disease. Approach and Results- Cultured valvular interstitial cells of stenotic aortic valve with calcification from patients undergoing valve replacement exhibited significant susceptibility to mineralization/osteoblastic transdifferentiation in response to phosphate. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312191DOI Listing
January 2019
1 Read

Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years.

N Engl J Med 2019 01;380(5):437-446

From the Nuffield Department of Surgical Sciences, John Radcliffe Hospital (D.P.T., B.L.), the Centre for Statistics in Medicine, Botnar Research Centre (S.G., D.G.A.), and the Health Economics Research Centre, Nuffield Department of Population Health (A.M.G.), University of Oxford, Oxford, the School of Clinical Sciences, University of Bristol, and Bristol Royal Infirmary, Bristol (U.B.), the Department of Cardiac Surgery, Royal Infirmary of Edinburgh, Edinburgh (V.Z.), Royal Papworth Hospital, Cambridge (C.C., C.S.), the Department of Cardiac Surgery, Freeman Hospital, Newcastle (S.C.), the Department of Cardiac Surgery, King's College Hospital (J.D.), and Royal Brompton Hospital and Imperial College London (J. Pepper), London, the Department of Cardiac Surgery, Royal Infirmary, Manchester (R.H.), the Department of Cardiac Surgery, University Hospital of Wales, Cardiff (P.O.), the Department of Cardiac Surgery, Royal Sussex County, Brighton (U.T.), and Norwich Medical School, University of East Anglia, and Norfolk and Norwich University Hospital, Norwich (M.F.) - all in the United Kingdom; the Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York Presbyterian Hospital (M.G.), and Mount Sinai St. Luke's (J. Puskas) - both in New York; the Center for Cardiovascular Research and Development, American Heart of Poland (A.B.), and the Department of Cardiac Surgery, Medical University of Silesia (M.D., S.W.), Katowice, and the Department of Cardiac and Thoracic Surgery, Wroclaw Medical University, Wroclaw (M.J.) - all in Poland; the Department of Cardiac Surgery, Austin Health, Melbourne, VIC, Australia (B.B., S.S.); and the Heart Institute of Pernambuco, Recife, Brazil (F.M.).

Background: Multiple arterial grafts may result in longer survival than single arterial grafts after coronary-artery bypass grafting (CABG) surgery. We evaluated the use of bilateral internal-thoracic-artery grafts for CABG.

Methods: We randomly assigned patients scheduled for CABG to undergo bilateral or single internal-thoracic-artery grafting. Read More

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http://dx.doi.org/10.1056/NEJMoa1808783DOI Listing
January 2019

Tissue factor pathway inhibitor in atherosclerosis.

Clin Chim Acta 2019 Jan 26;491:97-102. Epub 2019 Jan 26.

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerosis of Hunan Province, Hengyang Medical College, University of South China, Hengyang City, Hunan Province 421001, PR China. Electronic address:

Tissue factor pathway inhibitor (TFPI) reduces the development of atherosclerosis by regulating tissue factor (TF) mediated coagulation pathway. In this review, we focus on recent findings on the inhibitory effects of TFPI on endothelial cell activation, vascular smooth muscle cell (VSMC) proliferation and migration, inflammatory cell recruitment and extracellular matrix which are associated with the development of atherosclerosis. Meanwhile, we are also concerned about the impact of TFPI levels and genetic polymorphisms on clinical atherogenesis. Read More

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http://dx.doi.org/10.1016/j.cca.2019.01.024DOI Listing
January 2019

Effects of denosumab and alendronate on bone health and vascular function in hemodialysis patients: A randomized, controlled trial.

J Bone Miner Res 2019 Jan 28. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Mineral and bone disorders including osteoporosis are common in dialysis patients and contribute to increased morbimortality. However, whether denosumab and alendronate are effective and safe treatments in hemodialysis patients is not known. Thus, we conducted a prospective, three-center study of 48 hemodialysis patients who were diagnosed as having osteoporosis and had not received anti-osteoporotic agents previously. Read More

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http://dx.doi.org/10.1002/jbmr.3676DOI Listing
January 2019
1 Read

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ.

Nat Commun 2019 01 25;10(1):425. Epub 2019 Jan 25.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 100850, China.

Atherosclerosis-related cardiovascular diseases are the leading cause of mortality worldwide. Macrophages uptake modified lipoproteins and transform into foam cells, triggering an inflammatory response and thereby promoting plaque formation. Here we show that casein kinase 2-interacting protein-1 (CKIP-1) is a suppressor of foam cell formation and atherosclerosis. Read More

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http://dx.doi.org/10.1038/s41467-018-07895-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347643PMC
January 2019
1 Read

Wiener filter improves diagnostic accuracy of CAD SPECT images-comparison to angiography and CT angiography.

Medicine (Baltimore) 2019 Jan;98(4):e14207

Department of Cardiology, Dabbous Cardiac Centre, Adan Hospital, Hadiya, Kuwait.

Many discrepancy in selection of proper filter and its parameters for individual cases exists. The authors investigate the impact of the most common filters on patient NM images with coronary artery disease (CAD), and compare the results with the computerized tomography (CT)-Angio and angiography for accuracy.The investigation initiated by performing various single photon emission computerized tomography (SPECT)/CT scan of the national electrical manufacturers association chest phantoms having hot and cold inserts. Read More

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http://dx.doi.org/10.1097/MD.0000000000014207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358408PMC
January 2019

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model.

Int J Exp Pathol 2019 Jan 24. Epub 2019 Jan 24.

Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan.

Non-alcoholic steatohepatitis (NASH) is linked to increased cardiovascular risk, independent of the broad spectrum of metabolic syndrome risk factors. Stroke-prone (SP) spontaneously hypertensive rats (SHRSP5/Dmcr) fed a high-fat and high-cholesterol (HFC) diet developed hepatic lesions similar to those in human NASH pathology. These rats simultaneously developed lipid deposits in the mesenteric arteries, cardiac fibrosis, endothelial dysfunction and left ventricle (LV) diastolic dysfunction. Read More

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http://dx.doi.org/10.1111/iep.12301DOI Listing
January 2019
1 Read

Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):684-691

. PhD in Pathology, Professor of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.

Background And Purpose: Cerebral atherosclerosis is the main cause of lesions that contribute to vascular cognitive impairment and vascular dementia, followed by arteriosclerosis of small vessels and cerebral amyloid angiopathy. The purpose of this study was to compare the post-mortem radiological alterations of autopsied adults with the macroscopic alterations in the posterior region of these brains in order to establish a relationship between the two forms of analysis and to discuss the relevance of the prevention of vascular cognitive impairment in patients with encephalic atherosclerosis.

Materials And Methods: Thirteen brains were analysed macroscopically to assess the degree of atherosclerosis of the basilar and the posterior cerebral arteries. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.64.08.684DOI Listing
August 2018
5 Reads

Automated production of [ Ga]Ga-DOTANOC and [ Ga]Ga-PSMA-11 using a TRACERlab FX synthesis module.

J Labelled Comp Radiopharm 2019 Jan 22. Epub 2019 Jan 22.

Departamento de Radiología y Medicina Física. Centro de Investigaciones Médico-Sanitarias, Universidad de Málaga, Málaga, Spain.

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http://doi.wiley.com/10.1002/jlcr.3706
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http://dx.doi.org/10.1002/jlcr.3706DOI Listing
January 2019
1 Read

[Impact of coronary artery lesion calcification on the long-term outcome of patients with coronary heart disease after percutaneous coronary intervention].

Zhonghua Xin Xue Guan Bing Za Zhi 2019 Jan;47(1):34-41

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To investigate the impact of coronary lesion calcification on the long-term outcome of patients with coronary heart disease after percutaneous coronary intervention. In this prospective observational study, a total of 10 119 consecutive patients with coronary heart disease undergoing percutaneous coronary intervention from January 1 to December 31, 2 103 in our hospital were enrolled. The patients were divided into non/mild calcification group (8 268 cases) and moderate/severe calcification group (1 851 cases) according to the angiographic results. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2019.01.004DOI Listing
January 2019
3 Reads

[Plaque features in saphenous vein graft evaluated by virtual histology intravascular ultrasound].

Zhonghua Xin Xue Guan Bing Za Zhi 2019 Jan;47(1):26-33

Tianjin Cardiovascular Institute, Tianjin 300222, China.

To investigate the features of plaques of saphenous venous graft (SVG) with virtual histology intravascular ultrasound (VH-IVUS) in patients underwent coronary artery bypass graft surgery. From March 2016 to March 2018, a total of 45 patients ((64.4±7. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2019.01.003DOI Listing
January 2019
6 Reads

Effect of Statin Therapy on Arterial Wall Inflammation Based on 18F-FDG PET/CT: A Systematic Review and Meta-Analysis of Interventional Studies.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.

To evaluate by meta-analysis of interventional studies the effect of statin therapy on arterial wall inflammation. Arterial exposure to low-density lipoprotein (LDL) cholesterol levels is responsible for initiation and progression of atherosclerosis and arterial wall inflammation. 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (18F-FDG PET/CT) has been used to detect arterial wall inflammation and monitor the vascular anti-inflammatory effects of lipid-lowering therapy. Read More

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http://dx.doi.org/10.3390/jcm8010118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352284PMC
January 2019

Transcriptional activity of transforming growth factor beta1 gene and its receptors in patients with early stages of coronary artery disease.

Minerva Med 2019 Feb;110(1):92-94

Department of Cardiology, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.

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https://www.minervamedica.it/index2.php?show=R10Y2019N01A009
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http://dx.doi.org/10.23736/S0026-4806.18.05619-7DOI Listing
February 2019
3 Reads

Composite LITA-RITA-Y ("LIMA-RIMA-Y") graft configuration for coronary artery bypass grafting.

Multimed Man Cardiothorac Surg 2018 Dec 21;2018. Epub 2018 Dec 21.

Department of Cardio-Thoracic Surgery Erasmus University Medical Center Rotterdam The Netherlands.

This Core Skills tutorial elucidates the principal surgical techniques of constructing a composite Y-graft, using the left internal thoracic artery and the right internal thoracic artery, for on-pump coronary artery bypass grafting. Read More

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http://dx.doi.org/10.1510/mmcts.2018.034DOI Listing
December 2018

Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system.

J Neurol Sci 2019 Jan 16;398:9-15. Epub 2019 Jan 16.

Interfaculty Initiative in Information Studies / Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. Electronic address:

Purpose: Brain interstitial fluid plays an important role in the excretion of metabolic waste products into the cerebrospinal fluid through perivascular spaces (PVS). To investigate the normal function of PVS in healthy elderly individuals, we assessed the relationship between PVS and white matter hyperintensity (WMH) on MRI in two locations.

Methods: This study included 296 healthy individuals aged ≥60 years without a history of brain disease who underwent brain MRI. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.022DOI Listing
January 2019
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Spontaneous closure of an iatrogenic coronary artery fistula during recanalization of a chronic total occlusion lesion: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14068

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Rationale: Coronary perforation leading to fistula directed to the right ventricle is a rare complication of percutaneous coronary intervention (PCI). The reported outcomes vary from a stable state to rapid deterioration.

Patient Concerns: An 86-year-old man was diagnosed with non-ST elevation myocardial infarction, and arranged to PCI procedure for the chronic total occluded right coronary artery (RCA) after coronary angiography. Read More

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http://dx.doi.org/10.1097/MD.0000000000014068DOI Listing
January 2019
4 Reads
5.723 Impact Factor

Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.

Exp Ther Med 2019 Jan 30;17(1):107-114. Epub 2018 Oct 30.

Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light chain (MLC) kinase (MLCK)/phosphorylated (p)-MLC system via the mitogen activated protein kinase (MAPK) signaling pathway. Male New Zealand rabbits were randomly divided into 3 groups: The control group was administered an ordinary diet, whereas the high fat group and the Glabridin (2 mg/kg/d) intervention group were administered a high fat diet. Read More

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http://dx.doi.org/10.3892/etm.2018.6903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307408PMC
January 2019
2 Reads

Characteristics of patients with enhancing intracranial atherosclerosis and association between plaque enhancement and recent cerebrovascular ischemic events: a high-resolution magnetic resonance imaging study.

Acta Radiol 2019 Jan 16:284185118822645. Epub 2019 Jan 16.

1 Peking University Fifth School of Clinical Medicine, Beijing, PR China.

Background: Atherosclerotic plaque inflammation is a well-known risk factor for the development of ischemic stroke.

Purpose: To investigate the characteristics of patients with enhancing intracranial atherosclerosis and the relationship between plaque enhancement and recent cerebrovascular ischemic events by using high-resolution magnetic resonance imaging (HR-MRI).

Material And Methods: A total of 141 patients (102 men; mean age = 61. Read More

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http://dx.doi.org/10.1177/0284185118822645DOI Listing
January 2019
2 Reads
1.350 Impact Factor

Functional and morphologic study of retinal hypoperfusion injury induced by bilateral common carotid artery occlusion in rats.

Sci Rep 2019 Jan 14;9(1):80. Epub 2019 Jan 14.

Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, 100029, China.

Retinal hypoperfusion injury is the pathophysiologic basis of ocular ischemic syndrome (OIS) which often leads to severe visual loss. In this study, we aimed to establish a rat model of retinal chronic hypoperfusion by bilateral common carotid artery occlusion (BCCAO) and observe changes in the retinal function and morphology. We found that model rats showed retinal arteriosclerosis, slight dilated retinal vein, small hemangiomas, hemorrhages, vascular segmental filling, and nonperfused areas after 2 weeks of BCCAO. Read More

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http://dx.doi.org/10.1038/s41598-018-36400-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331588PMC
January 2019
1 Read

[Apolipoprotein A5 gene polymorphisms affect triglyceride metabolism and atherosclerotic cardiovascular diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1358-1363

Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Apolipoprotein A5 (Apo A5) is a novel member in apolipoprotein family, which is proven to be an important regulator in triglyceride metabolism, especially in adjusting the TG content in plasma. Apo A5 gene polymorphisms affect triglyceride metabolism and atherosclerotic cardiovascular diseases. The research focuses on -1131T>C, c. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.012DOI Listing
December 2018
2 Reads

Evaluation of serum adiponectin levels in diabetic nephropathy.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):128-131. Epub 2018 Apr 24.

New Kasr Alainy Hospital, Cairo University, Egypt.

Introduction: Diabetic nephropathy is one of the major microvascular complications of diabetes mellitus. Adiponectin is an adipose tissue-derived cytokine that was identified in a human adipose tissue cDNA library. Serum adiponectin levels are found to be reduced in various pathological states including obesity, diabetes mellitus, ischaemic heart disease and arteriosclerosis obliterans and elevated in end stage renal diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183014
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http://dx.doi.org/10.1016/j.dsx.2018.04.035DOI Listing
April 2018
8 Reads

Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders.

JAMA Neurol 2019 Jan 14. Epub 2019 Jan 14.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Importance: There are limited data concerning the risk of metabolic and cardiovascular disorders among individuals with Tourette syndrome (TS) or chronic tic disorder (CTD).

Objective: To investigate the risk of metabolic and cardiovascular disorders among individuals with TS or CTD over a period of 40 years.

Design, Settings, And Participants: This longitudinal population-based cohort study included all individuals living in Sweden between January 1, 1973, and December 31, 2013. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4279DOI Listing
January 2019
5 Reads

Helicobacter cinaedi associated with atypical Raynaud syndrome.

Clin Microbiol Infect 2019 Jan 11. Epub 2019 Jan 11.

Département de Bactériologie-Virologie, Hygiène et Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire (CHRU) de Brest, Brest, France; UMR1078 "Génétique, Génomique Fonctionnelle et Biotechnologies", INSERM, Université de Brest, EFS, IBSAM, Brest, France.

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193000
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http://dx.doi.org/10.1016/j.cmi.2019.01.001DOI Listing
January 2019
7 Reads

The association between local arteriosclerosis of the prostatic arteries and chronic inflammation in human benign prostatic enlargement.

Prostate 2019 Jan 13. Epub 2019 Jan 13.

Departments of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Background: To elucidate the pathogenesis of benign prostatic enlargement (BPE) in humans due to chronic inflammation caused by arteriosclerosis, the relationships between prostate size and the degree of chronic inflammation induced by local arteriosclerosis were investigated.

Methods: The present cohort included 50 subjects who underwent robot-assisted radical prostatectomy (RARP) in a prospective study. The presence or absence of local arteriosclerosis in the prostatic arteries removed during RARP was evaluated by microscopic assessment. Read More

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http://dx.doi.org/10.1002/pros.23763DOI Listing
January 2019
1 Read

Dietary natural products as emerging lipoprotein(a)-lowering agents.

J Cell Physiol 2019 Jan 13. Epub 2019 Jan 13.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Elevated plasma lipoprotein(a) (Lp(a)) levels are associated with an increased risk of cardiovascular disease (CVD). Hitherto, niacin has been the drug of choice to reduce elevated Lp(a) levels in hyperlipidemic patients but its efficacy in reducing CVD outcomes has been seriously questioned by recent clinical trials. Additional drugs may reduce to some extent plasma Lp(a) levels but the lack of a specific therapeutic indication for Lp(a)-lowering limits profoundly reduce their use. Read More

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http://dx.doi.org/10.1002/jcp.28134DOI Listing
January 2019
2 Reads
3.839 Impact Factor

The Diagnostic Classification of Critical Limb Ischemia.

Authors:
Nobuyoshi Azuma

Ann Vasc Dis 2018 Dec;11(4):449-457

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

With the global epidemic of diabetes, diagnosis of critical limb ischemia (CLI) has become very complex due to mixture of microangiopathy, infection and sometimes neuropathy with the pure ischemia. We still sometimes encounter the patients with extensive tissue loss due to misdiagnosis of ischemia or infection in previous hospital. For adequate decision making of proper treatment selection for each critical ischemic limb without missing the adequate intervention timing, a new classification system good for not only vascular specialists but also gate keeping clinicians working in the era of diabetes has been desired. Read More

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http://dx.doi.org/10.3400/avd.ra.18-00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326054PMC
December 2018
3 Reads

Use of the SYNTAX Score II to predict mortality in interventional cardiology: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(2):e14043

Department of Cardiology.

Background: As the SYNTAX Score has limitations, it should be replaced by another better angiographic tool. By comparing mortality that was observed following percutaneous coronary intervention (PCI) in patients who were allotted a low versus a high score, we aimed to systematically investigate mortality prediction using the SYNTAX Score II in Interventional Cardiology.

Methods: Electronic databases were searched for relevant publications using the terms "SYNTAX Score II and percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1097/MD.0000000000014043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336650PMC
January 2019

The association of depression following percutanous coronary intervention with adverse cardiovascular events: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(2):e13952

Cardiovascular diseases center, Xiyuan hospital of China academy of Chinese medical sciences.

Introduction: Percutanous coronary intervention (PCI) has been increasingly used for patients suffered from severe coronary artery disease. However, physical trauma and potential adverse events related to the procedure often result in detrimental psychological stress. Accumulating evidences have shown that depression is closely related to coronary artery disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336612PMC
January 2019
2 Reads

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(2):e13813

Department of First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

To evaluate the association between gene polymorphisms of TNF-α G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12. Read More

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http://dx.doi.org/10.1097/MD.0000000000013813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336626PMC
January 2019
2 Reads
5.723 Impact Factor

Coronary artery dilation associated with anti-synthetase syndrome in an adolescent.

Pediatr Rheumatol Online J 2019 Jan 10;17(1). Epub 2019 Jan 10.

Department of Pediatrics, University of Texas McGovern Medical School, 6431 Fannin St. MSB 3.228, Houston, TX, USA.

Background: Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune disorders primarily affecting skeletal muscle. Pediatric coronary artery dilation is frequently discussed in Kawasaki disease. However, it has yet to be reported in the IIMs or antisynthetase syndrome. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-019-0304-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329119PMC
January 2019
4 Reads

Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney.

Am J Transplant 2019 Jan 10. Epub 2019 Jan 10.

Division of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota.

It is unclear whether structural findings in the kidneys of living kidney donors predict postdonation kidney function. We studied living kidney donors who had a kidney biopsy during donation. Nephron size was measured by glomerular volume, cortex volume per glomerulus, and mean cross-sectional tubular area. Read More

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http://doi.wiley.com/10.1111/ajt.15259
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http://dx.doi.org/10.1111/ajt.15259DOI Listing
January 2019
5 Reads

Accelerated inflammation in peripheral artery disease patients with periodontitis.

J Periodontal Implant Sci 2018 Dec 27;48(6):337-346. Epub 2018 Dec 27.

Department of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: Peripheral artery disease (PAD) is a form of arteriosclerosis that occurs in the extremities and involves ischemia. Previous studies have reported that patients with periodontitis are at high risk for PAD. However, the relationship between these 2 diseases has not yet been fully elucidated. Read More

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http://dx.doi.org/10.5051/jpis.2018.48.6.337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312877PMC
December 2018
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Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.

Antioxid Redox Signal 2019 Jan 8. Epub 2019 Jan 8.

Vanderbilt University Medical Center, Division of Clinical Pharmacology, Nashville, Tennessee, United States ;

Significance: Vascular dysfunction plays a key role in the development of arteriosclerosis, heart disease and hypertension which causes one-third of deaths worldwide. Vascular oxidative stress and metabolic disorders contribute to vascular dysfunction leading to impaired vasorelaxation, vascular hypertrophy, fibrosis and aortic stiffening. Mitochondria are critical in the regulation of metabolic and antioxidant functions; therefore, mitochondria targeted treatments could be beneficial. Read More

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https://www.liebertpub.com/doi/10.1089/ars.2018.7632
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http://dx.doi.org/10.1089/ars.2018.7632DOI Listing
January 2019
4 Reads

Autopsy report of a late delayed radiation injury after a period of 45 years.

Neuropathology 2019 Jan 4. Epub 2019 Jan 4.

Faculty of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

For delayed radiation injury, image analysis has considerably advanced, but neuropathological findings are still required to establish diagnosis. A patient who had received radiation therapy for pineal germinoma at age 14 developed neurological and psychiatric abnormalities after 15 years as a late delayed radiation injury. Autopsy at age 59 revealed diffuse changes in the white matter consisting in order of severity of myelin pallor, demyelination, and necrosis which were characterized by a lack of glial reaction. Read More

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http://doi.wiley.com/10.1111/neup.12528
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http://dx.doi.org/10.1111/neup.12528DOI Listing
January 2019
7 Reads

Serum angiopoietin-2 concentrations of post-PCI are correlated with the parameters of renal function in patients with coronary artery disease.

Medicine (Baltimore) 2019 Jan;98(1):e13960

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University.

Patients with coronary artery disease (CAD) frequently have comorbidity of chronic kidney disease (CKD). Their renal function may deteriorate because of the use of contrast agent after percutaneous coronary intervention (PCI). Angiopoietin-2 (Ang-2), which is highly expressed in the site of angiogenesis, plays an important role in both CAD and CKD. Read More

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http://dx.doi.org/10.1097/MD.0000000000013960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344115PMC
January 2019
2 Reads

[Screening and diagnostic framework of vascular dementia in Chinese population].

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):10-16

Department of Neurology, Peking University First Hospital, Beijing 100034, China.

For lack of cognitive screening standard system and controversy over the value of imaging for cerebrovascular diseases in China, the research group of Alzheimer's Disease Chinese (ADC) studied the knowledge of neuropsychology, neuroimaging and clinical neurology, systematically reviewed the diagnostic techniques such as memory, language, visuospatial, executive, function, and magnetic resonance imaging (MRI) of cerebrovascular diseases, and their optimal threshold and diagnostic value for vascular dementia. Via a consensus meeting, the diagnostic guidelines and practical screening process are combined to construct a framework in Chinese population, which is based on the objective evidence of medical history and clinical evaluation. The diagnosis of vascular dementia is supported by imaging evidence of cerebrovascular diseases and differentiates from other causes of dementia or comorbidities. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.003DOI Listing
January 2019
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Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population.

Indian Heart J 2018 Dec 19;70 Suppl 3:S480-S482. Epub 2018 Jun 19.

Research and Development, SRL Ltd Prime Square Building, Plot No 1, S. V. Road, Goregaon (W), Mumbai, 400 062, India. Electronic address:

Genome wide association study has identified rs7025486 G>A polymorphism within DAB2IP (Disabled homolog 2-interacting protein) gene with increased risk of coronary heart disease (CAD). In this study we have determined the frequency and association of rs7025486 with CAD in Indians. The study was performed on 214 patients with CAD and 125 controls. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309282PMC
December 2018

Imaging during percutaneous coronary intervention for optimizing outcomes.

Indian Heart J 2018 Dec 18;70 Suppl 3:S456-S465. Epub 2018 Aug 18.

Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Angiography is the current gold standard for imaging during percutaneous coronary interventions but has significant limitations. Catheter-based intravascular imaging techniques such as intravascular ultrasound and the more recent optical coherence tomography have the potential to overcome these limitations and thus optimize clinical outcomes. In this update, we discussed the current applications of the available imaging techniques, existing evidence, continuing unmet needs, and potential areas for further research. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309719PMC
December 2018
1 Read