182,651 results match your criteria Arteriosclerosis Thrombosis and Vascular Biology[Journal]


Diagnostic yield of sequencing familial hypercholesterolemia genes in individuals with primary hypercholesterolemia.

Rev Esp Cardiol (Engl Ed) 2020 Jul 10. Epub 2020 Jul 10.

Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco, UPV/EHU, Bilbao, Spain; Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain.

Introduction And Objectives: Our objective was to approximate the prevalence of mutations in candidate genes for familial hypercholesterolemia (FH) in a middle-aged Spanish population and to establish the predictive value of criteria for clinical suspicion in the detection of causative mutations.

Methods: Unrelated individuals aged ≥ 18 years from the Aragon Workers' Health Study (AWHS) with high low-density lipoprotein cholesterol (LDL-C) and clinical suspicion of FH (participants with LDL-C concentrations above the 95th percentile, participants with premature cardiovascular disease and/or participants with high LDL-C [130 mg/dL] under statin therapy), assuming that any participant with FH exhibits at leats 1 trait, were selected and the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes were sequenced by next generation sequencing technology.

Results: Of 5400 individuals from the AWHS, 4514 had complete data on lipid levels and lipid-lowering drugs, 255 participants (5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rec.2020.06.003DOI Listing

Evaluation of characteristics of left-sided colorectal perfusion in elderly patients by angiography.

World J Gastroenterol 2020 Jun;26(24):3484-3494

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: Handling of the inferior mesenteric artery (IMA) and maintaining anastomotic perfusion are important in radical resection of left-sided colorectal cancer. However, the branching of this artery and the drainage patterns of this vein vary among individuals, and the characteristics and perfusion region of this artery in elderly patients remain unclear.

Aim: To evaluate the characteristics and perfusion region of the IMA in elderly patients using angiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v26.i24.3484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327791PMC

Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study.

Int J Clin Pract 2020 Jul 10:e13610. Epub 2020 Jul 10.

Department of Clinical Medicine, Miguel Hernandez University, San Juan de Alicante, Spain.

Background And Aim: Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL-C and HDL-C, but with alterations in the number and size of lipoprotein particles (as measured by nuclear magnetic resonance [NMR]) and to analyze their sociodemographic, clinical, and biochemical characteristics.

Methods: Cross-sectional study in occupational risks prevention center in Castellón (Spain) in 2017 and 2018, in consecutively recruited adults (18-65 years) with no known CVD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.13610DOI Listing

Stable coronary artery disease: Intervene or not?

Cleve Clin J Med 2020 06 30;87(7):410-415. Epub 2020 Jun 30.

Vice-Chairman, Department of Cardiovascular Medicine, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3949/ccjm.87a.20048DOI Listing
June 2020
2.712 Impact Factor

Administration of Slow-Release Synthetic Prostacyclin Agonist Promoted Angiogenesis and Skeletal Muscle Regeneration for Limb Ischemia.

Mol Ther Methods Clin Dev 2020 Sep 22;18:119-130. Epub 2020 May 22.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

Gene or cell therapy is currently not fully efficacious for arteriosclerosis obliterans (ASO). In this study, we determined whether YS-1402, a slow-release synthetic prostacyclin agonist, promoted neovascularization and skeletal muscle regeneration in a mouse model of critical limb ischemia (CLI). We ligated the femoral artery and its branches to obtain the CLI mouse model, administered saline (S group) or YS-1402 (YS group) to the thigh adductor 1 week after femoral artery occlusion, and evaluated tissue blood flow after surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtm.2020.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321796PMC
September 2020

Microecological treatment of hyperuricemia using Lactobacillus from pickles.

BMC Microbiol 2020 Jul 6;20(1):195. Epub 2020 Jul 6.

Department of LiWan Hospital, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.

Background: Hyperuricemia is one of the important risk factors for gout, arteriosclerosis, cardiovascular and cerebrovascular disease. Lactobacillus has attracted much attention due to its role in the regulation of intestinal function and tumor resistance, but its ability to reduce uric acid is unclear. Pickles are a traditional fermented food rich in lactic acid bacteria (LAB). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12866-020-01874-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336419PMC

Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2.

Mol Med Rep 2020 Apr 24. Epub 2020 Apr 24.

Department of Cardiothoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China.

The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are critical in the progression of atherosclerosis (AS). Platelet‑derived growth factor type BB (PDGF‑BB) may induce VSMC proliferation and migration. miR‑142‑5p plays a critical role in various biological processes, including tumorigenesis, angiogenesis and inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2020.11093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248461PMC

Danlou Tablet () Improves Chronic Intermittent Hypoxia-induced Dyslipidemia and Arteriosclerosis by HIF-1 α-Angptl4 mRNA Signaling Pathway.

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Objective: To detect whether Danlou Tablet (, DLT) regulates the hypoxia-induced factor (HIF)-1 α-angiopoietin-like 4 (Angptl4) mRNA signaling pathway and explore the role of DLT in treating chronic intermittent hypoxia (CIH)-induced dyslipidemia and arteriosclerosis.

Methods: The mature adipocytes were obtained from 3T3-L1 cell culturation and allocated into 8 groups including control groups (Groups 1 and 5, 0.1 mL of cell culture grade water); DLT groups (Groups 2 and 6, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11655-020-3255-8DOI Listing

Effect of Obesity and/or Ligature-induced Periodontitis on Aortic Wall Thickness in Wistar Rats.

Acta Odontol Latinoam 2020 Apr;33(1):50-55

Universidade Federal do Rio Grande do Sul, Faculdade de Odontologia, Departmento de Periodontia, Rio Grande do Sul, Brasil.

The purpose of this study was to evaluate aortic wall thickness after periodontal disease and/or obesity induction in a Wistar rat model.Sixty male Wistar rats were randomly divided into four groups: control (CT), periodontal disease (PD), obesity (OB), and obesity plus periodontal disease (OB+PD). Groups OB and OB+PD received cafeteria diet for 17 weeks. Read More

View Article

Download full-text PDF

Source

[Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(1):113-117

Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Atherosclerosis is an important pathological basis for coronary artery disease. ANRIL is an antisense non-coding RNA located in Chr9p21 locus, which was identified as the most significant risk locus associated with atherosclerosis. ANRIL can produce multiple transcripts including linear and circular transcripts after various transcript splicing. Read More

View Article

Download full-text PDF

Source

[Prognosis of patients with vulnerable plaques indicated by coronary CT angiography].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(1):76-81

Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Objective: To investigate the prognosis of patients with vulnerable plaque indicated by coronary CT angiography (CCTA).

Methods: Totally 1963 patients underwent CCTA from February 2nd 2015 to September 13th 2015, and 2728 coronary borderline lesions (stenosis of 50%-70%) were detected. Among them 804 patients had vulnerable plaques and 1159 patients had stable plaques. Read More

View Article

Download full-text PDF

Source

Pro- and anti-inflammatory factors, vascular stiffness and outcomes in chronic hemodialysis patients.

Physiol Int 2020 Jul 2. Epub 2020 Jul 2.

1FMC Dialysis Center Pécs, Pécs, Hungary.

Objective: In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them to pro-inflammatory and protective factors.

Patients: 96 consecutive patients receiving regular HD were included. 20 adult patients without major renal, cardiovascular or metabolic morbidities served as controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/2060.2020.00026DOI Listing

Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.

Alcohol Clin Exp Res 2020 Jul 3. Epub 2020 Jul 3.

From the Columbia University Mailman School of Public Health, New York, New York.

Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to cardiovascular disease (CVD), the leading cause of death for men and women in the United States and of global mortality. This study examined associations between reductions in WHO risk drinking levels and subsequent risk for CVD.

Methods: In a US national survey, 1,058 very-high-risk and high-risk drinkers participated in Wave 1 interviews (2001 to 2002) and Wave 2 follow-ups (2004 to 2005). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.14386DOI Listing

[Correlation of Transluminal Attenuation Gradientdistal with Corrected Contrast Opacification with Anterior Coronary Atherosclerosis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):354-358

Department of CT,the Affiliated Hospital of North China University of Science and Technology,Tangshan,Hebei 063000,China.

To explore the correlation between the transluminal attenuation gradient with corrected contrast opacification(TAG-CCO)and the severity of atherosclerotic stenosis in the anterior segment of myocrardial bridge(MB). The imaging data of 200 patients diagnosed with left anterior descending branch(LAD)single MB and coronary atherosclerosis in the anterior segment of MB were retrospectively analyzed.According to MB types,the patients were divided into two groups:incomplete and complete. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3881/j.issn.1000-503X.11488DOI Listing

Effects of Evening-Only Low-Carbohydrate Meal on Healthy Volunteers.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):229-236

Graduate School of Nursing and Nutrition, Tenshi College.

We performed a pre/post-interventional study with participants as self-controls to evaluate the effects of consuming an evening-only low-carbohydrate meal (LCM) at 1800 h on biochemical measures of glucose and lipid metabolism. Study participants comprised 14 healthy men (age range, 20-29 y) who, consumed standard test meals (STMs) or LCM at 1800 h. Blood samples were collected at fasting, and at 60-, 120-, and 240 min after the start of the meals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3177/jnsv.66.229DOI Listing
January 2020

The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):213-218

Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University.

Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions. Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3177/jnsv.66.213DOI Listing
January 2020

Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study.

Clin Interv Aging 2020 4;15:853-863. Epub 2020 Jun 4.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Purpose: There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CIA.S248816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283487PMC
June 2020
1.824 Impact Factor

Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients.

Int J Mol Sci 2020 Jun 28;21(13). Epub 2020 Jun 28.

Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.

microRNAs (miRNAs) are small RNAs that regulate different biological processes. Our objective was to identify miRNAs dysregulated in plasma and tissue of patients with abdominal aortic aneurysm (AAA) and explore new potential targets involved in AAA. Fifty-seven subjects were recruited for a plasma study (30 AAA patients, 16 healthy volunteers and 11 patients with atherosclerosis). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21134600DOI Listing

[Level of N-terminal fragment of brain natriuretic peptide progenitor and atherosclerotic damage of brachocephalic arteries in patients with rheumatoid arthritis with inefficiency and/or injurability of basic anti - inflammatory treatment].

Ter Arkh 2019 May 15;91(5):34-39. Epub 2019 May 15.

V.A. Nasonova Scientific and Research Institute of Rheumatology.

The high prognostic significance of the concentration of the N-terminal - pro-B-type natriuretic peptide (NT-proBNP) in the development of cardiovascular diseases (CVD) was identified for rheumatoid arthritis (RA) and general populations.

Aim: to investigate the significance of NT-proBNP level in patients (pts) with RA with the ineffectiveness and/or intolerance of basic anti - inflammatory therapy; compare the level of NT-proBNP with atherosclerotic lesion of the brachiocephalic arteries (BCA), traditional risk factors and inflammatory markers.

Materials And Methods: The investigation enrolled 28 pts (24women/4men) with the lack of efficacy/resistance and/or intolerance of basic anti - inflammatory drugs (DMARDs); median age was 55 [46; 61] years, median disease duration 114 [60; 168] month; DAS28 6,2 [5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2019.05.000286DOI Listing

IVUS guidance during left main PCI: not if, but when and how.

EuroIntervention 2020 Jun;16(3):189-191

Columbia University Medical Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4244/EIJV16I3A32DOI Listing

New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular Index (CAVI).

J Atheroscler Thromb 2020 Jun 26. Epub 2020 Jun 26.

Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.

Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness from the origin of the aorta to the ankle, was developed in 2004. An important feature of this index is the independency from blood pressure at the time of measurement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5551/jat.RV17043DOI Listing

Improvement of image quality on low-dose dynamic myocardial perfusion computed tomography with a novel 4-dimensional similarity filter.

Medicine (Baltimore) 2020 Jun;99(26):e20804

Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido.

The aim of this study was to evaluate the effect of a novel 4-dimensional similarity filter (4DSF) on quantitative and qualitative parameters of low-dose dynamic myocardial computed tomography perfusion (CTP) images.In this retrospective study, medical records of 32 patients with suspected or known coronary artery disease who underwent dynamic myocardial CTP at 80 kV were included. The 4DSF reduces noise by averaging voxels that have similar dynamic behavior after adaptive iterative dose reduction 3D (AIDR3D) and deformable image registration were applied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328929PMC

Role of Neuronal Nitric Oxide Synthase on Cardiovascular Functions in Physiological and Pathophysiological States.

Nitric Oxide 2020 Jun 23. Epub 2020 Jun 23.

Chapman University and University of California, Irvine, CA, USA. Electronic address:

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on the central nervous system, particularly on brain regions such as the ventrolateral medulla (VLM) and the periaqueductal gray matter (PAG), and on blood vessels and the heart that are involved in the regulation and control of the cardiovascular system (CVS). Furthermore, we shall also review the functional aspects of nNOS during several physiological, pathophysiological, and clinical conditions such as exercise, pain, cerebral vascular accidents or stroke and hypertension. For example, during stroke, a cascade of molecular, neurochemical, and cellular changes occur that affect the nervous system as elicited by generation of free radicals and nitric oxide (NO) from vulnerable neurons, perioxide formation, superoxides, apoptosis, and the differential activation of three isoforms of nitric oxide synthases (NOSs), and can exert profound effects on the CVS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2020.06.004DOI Listing

[Acral ischaemia with multiple microthromboses and imminent gangrene in a 73-year-old woman with COVID-19].

Ugeskr Laeger 2020 06;182(26)

This is a report of an atypical presentation of COVID-19. The patient had sparse pulmonary symptoms despite characteristic COVID-19 lesions on CT-thorax and developed severe acral ischaemic change, after a few days of hospitalisation. The condition could not be explained by classical sepsis with hypotension and hypoperfusion, disseminated intravascular coagulation, vasculitis, endocarditis or severe peripheral arteriosclerosis. Read More

View Article

Download full-text PDF

Source

The relationship between neutrophil-lymphocyte ratio and in-stent restenosis in superficial femoral artery.

Biosci Rep 2020 Jul;40(7)

Department of Intervention,The fourth affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

The present study aimed to investigate the relationship between an increase in the pre- and post-operative neutrophil-lymphocyte ratio (NLR) and superficial femoral artery in-stent restenosis (ISR) rate. We recruited 199 patients that underwent superficial femoral artery stenting for lower extremity arteriosclerosis obliterans at our hospital from March 2015 to July 2018. Patients were divided into two groups according to the occurrence of ISR within 1 year (group 1, ISR and group 2, Non-ISR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20193448DOI Listing

Twelve months of exercise training did not halt abdominal aortic calcification in patients with CKD - a sub-study of RENEXC-a randomized controlled trial.

BMC Nephrol 2020 Jun 22;21(1):233. Epub 2020 Jun 22.

Department of Clinical Sciences Lund, Nephrology, Lund, Sweden, Lund University, Skåne University Hospital, Alwallhuset Barngatan 2A, 121 85, Lund, Sweden.

Background: Arteriosclerosis is prevalent in patients with chronic kidney disease (CKD). Our aims were to investigate (1) the effects of 12 months of either balance- or strength- both in combination with endurance training on abdominal aortic calcification (AAC); on some lipids and calcific- and inflammatory markers; and (2) the relationships between the change in AAC score and these markers in non-dialysis dependent patients with CKD stages 3 to 5.

Methods: One hundred twelve patients (mean age 67 ± 13 years), who completed 12 months of exercise training; comprising either balance- or strength training, both in combination with endurance training; with a measured glomerular filtration rate (mGFR) 22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01881-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310004PMC

Cholesterol in Relation to COVID-19: Should We Care about It?

J Clin Med 2020 Jun 18;9(6). Epub 2020 Jun 18.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz (MUL), Zeromskiego 113, 90-549 Lodz, Poland.

Current data suggest that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease-19 (COVID-19) seems to follow a more severe clinical course in patients with cardiovascular disease (CVD), hypertension, and overweight/obesity. It appears that lipid-lowering pharmacological interventions, in particular statins, might reduce the risk of cardiovascular complications caused by COVID-19 and might potentially have an additional antiviral activity. It has been shown that high cholesterol levels are associated with more lipid rafts, subdomains of the plasma membrane that can harbour angiotensin-converting enzyme 2 (ACE2) receptors for the S-protein of SARS-CoV-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9061909DOI Listing

Quantitative Histogram Analysis on Intracranial Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging Study.

Stroke 2020 Jul 17;51(7):2161-2169. Epub 2020 Jun 17.

Department of Radiology (Z.S., J. Li, W.P., T.J., Q.L., J. Lu), Changhai Hospital, Naval Medical University, Shanghai, China.

Background And Purpose: Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events. This study aims to evaluate differences in histogram features between culprit and nonculprit intracranial atherosclerosis using high-resolution magnetic resonance imaging.

Methods: Two hundred forty-seven patients with intracranial atherosclerosis who underwent high-resolution magnetic resonance imaging sequentially between January 2015 and December 2016 were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.120.029062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306260PMC
July 2020
5.723 Impact Factor

Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.

Mol Biol Rep 2020 Jun 21. Epub 2020 Jun 21.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

The oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a pivotal role in the initiation and progression of atherosclerosis which is a complex and progressive disorder. Paraoxonase1 (PON1), which is required for lipid metabolism, is believed to protect LDL from oxidation. The relationship between PON1 gene Leusin55Methionin (L55M) and Glutamine192Arginine (Q192R) polymorphisms in western Iranians with atherosclerosis and its association with enzyme activity and oxidized low-density lipoprotein (oxLDL) were examined in the present study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11033-020-05585-2DOI Listing
June 2020
2.024 Impact Factor

Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans.

PeerJ 2020 11;8:e9305. Epub 2020 Jun 11.

Department of Vascular Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Objectives: This study set out to analyze the difference of heat shock protein 27 (HSP27) and its phosphorylation in patients with lower extremity arteriosclerosis obliterans (LEASO) at different stages. This research also examined their clinical significance in this disease.

Methods: Blood samples from 60 patients with LEASO were collected and divided into two groups according to ankle-brachial index (ABI): group A (ABI ≤ 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293856PMC

Feasibility, Safety, and Effectiveness of a Mobile Application in Cardiac Rehabilitation.

Isr Med Assoc J 2020 06;22(6):357-363

Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Tel Hashomer, Israel.

Background: Cardiac rehabilitation (CR) is underutilized globally despite evidence of clinical benefit. Major obstacles for wider adoption include distance from the rehabilitation center, travel time, and interference with daily routine. Tele-cardiac rehabilitation (tele-CR) can potentially address some of these limitations, enabling patients to exercise in their home environment or community. Read More

View Article

Download full-text PDF

Source

[Antithrombotic treatments in patients with SARS-CoV-2 infection: from current evidence to reasonable recommendations - A position paper from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology].

G Ital Cardiol (Rome) 2020 Jul;21(7):489-501

Dipartimento Cardiovascolare-AUSL Romagna, U.O. Cardiologia, Ospedale S. Maria delle Croci, Ravenna.

Given the high prevalence of preexisting cardiovascular diseases and the increased incidence of adverse cardiovascular events in patients hospitalized for SARS-CoV-2 infection, the identification of optimal antithrombotic approaches in terms of risk/benefit ratio and outcome improvement appears crucial in this setting. In the present position paper we collected current evidence from the literature to provide practical recommendations on the management of antithrombotic therapies (antiplatelet and anticoagulant) in various clinical contexts prevalent during the SARS-CoV-2 outbreak: in-home management of oral anticoagulant therapy; interactions between drugs used in the SARS-CoV-2 infection and antithrombotic agents; in-hospital management of antithrombotic therapies; diagnosis, risk stratification and treatment of in-hospital thrombotic complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1714/3386.33634DOI Listing

Epidemiological investigation of infection in elderly people in Beijing.

World J Clin Cases 2020 Jun;8(11):2173-2180

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The () infection rate in China is approximately 50%. is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v8.i11.2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281052PMC

Association between Plasma Adipocytokines Levels and Intracranial versus Extracranial Atherosclerotic among Chinese Patients with Stroke.

Iran J Public Health 2020 Apr;49(4):645-653

Department of Neurology, PLA 254 Hospital, Tianjin300141, P.R.China.

Background: To detect the levels of plasma Adipocytokines, TNF-α, IL-6 and PAI-1 in patients with intracranial and extracranial arteriosclerosis.

Methods: From September 2015 to September 2017, 318 patients aged ≥60 years were enrolled. Overall, 192 patients were included in the case group (intracranial and extracranial arteriosclerosis group). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283181PMC

The Background of Calculating CAVI: Lesson from the Discrepancy Between CAVI and CAVI.

Vasc Health Risk Manag 2020 21;16:193-201. Epub 2020 May 21.

Mihama Hospital, Chiba, Japan.

Arterial stiffness is a good predictor of cardiovascular events. As a substitute for elastic modulus representing stiffness, pulse wave velocity (PWV) has been used for over a century as it is easy to measure; however, PWV is known to essentially depend on blood pressure at the time of measurement. The cardio-ankle vascular index (CAVI) is a relatively new index of global arterial stiffness of the origin of the aorta to the ankle arteries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/VHRM.S223330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251085PMC

Coronary revascularization after heart transplant - the search for prognostic factors.

Arch Med Sci 2020 18;16(4):789-795. Epub 2020 Apr 18.

Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

Introduction: Survival after heart transplantation (HTX) is extended due to continuous improvement of medical care, allowing enough time for coronary artery vasculopathy to develop. Data on the clinical outcome of cardiac transplantation patients after percutaneous coronary intervention (PCI) are still not extensively explored. The aim of our study was to assess whether heart transplantation itself compromises the outcome in patients undergoing percutaneous coronary intervention and to assess survival rates as well as major cardiovascular complications in heart transplant recipients who had undergone PCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/aoms.2017.71847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286336PMC

Effects of Valsartan on Restenosis in Patients with Arteriosclerosis Obliterans of the Lower Extremities Undergoing Interventional Therapy: A Prospective, Randomized, Single-Blind Trial.

Med Sci Monit 2020 Jun 16;26:e919977. Epub 2020 Jun 16.

Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province, Cangzhou, Hebei, China (mainland).

BACKGROUND The aim of this study was to further clarify the effects of valsartan on restenosis in patients with arteriosclerosis obliterans of the lower extremities. MATERIAL AND METHODS Patients with arteriosclerosis obliterans of the lower extremities undergoing continuous stent implantation in the superficial femoral artery were enrolled and randomly divided into an ARB group and a control group. Patients in the ARB group received valsartan orally in a single-blind manner and were followed up for 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.919977DOI Listing

From plumbers to vascular restorers: has the Promethean promise of bioresorbable coronary scaffolds yet to be fulfilled?

EuroIntervention 2020 Jun 12;16(2):e106-e108. Epub 2020 Jun 12.

Hospital Clinico Universitario San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4244/EIJV16I2A17DOI Listing

Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status.

J Am Heart Assoc 2020 Jul 13;9(13):e017288. Epub 2020 Jun 13.

Marshall University Huntington WV.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.120.017288DOI Listing

The important role of histone deacetylases in modulating vascular physiology and arteriosclerosis.

Atherosclerosis 2020 Jun 22;303:36-42. Epub 2020 May 22.

University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Cardiovascular diseases are the leading cause of deaths in the world. Endothelial dysfunction followed by inflammation of the vessel wall leads to atherosclerotic lesion formation that causes ischemic heart and myocardial hypertrophy, which ultimately progress into cardiac dysfunction and failure. Histone deacetylases (HDACs) have been recognized to play crucial roles in cardiovascular disease, particularly in the epigenetic regulation of gene transcription in response to a variety of stresses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2020.04.020DOI Listing
June 2020
3.994 Impact Factor

Hepatoma-derived growth factor enhances osteoblastic transformation of rat aortic vascular smooth muscle cells in vitro.

Life Sci 2020 Jun 11;256:117964. Epub 2020 Jun 11.

Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan. Electronic address:

Aims: Vascular smooth muscle cells (VSMCs) are important regulators of vascular functions and their conversion to osteoblasts is a key to development of vascular calcification. This study aimed to characterize in vitro effect of hepatoma-derived growth factor (HDGF) on phenotypic conversion of cultured aortic VSMCs into osteoblast-like cells.

Materials And Methods: Cell proliferation and migration assays were used to examine cell behaviors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2020.117964DOI Listing

The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo.

Exp Eye Res 2020 Jun 10;197:108113. Epub 2020 Jun 10.

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China. Electronic address:

Hyperosmolarity is pro-inflammatory stress to the ocular surface epithelium associated with dry eye disease (DED). Astaxanthin (AST) is a kind of carotene, which exists in seafood and plays important roles in the amelioration of inflammatory diseases like arteriosclerosis, inflammatory bowel disease, sepsis, rheumatoid arthritis, gastric inflammation, brain inflammatory diseases. The aim of this study was to characterize the protective effect and potential mechanism of AST on DED in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2020.108113DOI Listing

A Case Report of Werner's Syndrome With a Novel Mutation From India.

Cureus 2020 May 8;12(5):e8025. Epub 2020 May 8.

Pathology, University of Washington, Seattle, USA.

Werner's syndrome (WS) or progeria adultorum is a heritable autosomal recessive disease in which the aging process is accelerated, just after puberty. It is caused by mutations in the WRN gene, which encodes a member of the RECQ family of DNA helicases and has a role in DNA repair. WS is being more appropriately recognized as a condition in which the lack of WRN protein results in an overall decline in the normal physiological functions of various organs rather than premature aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380PMC

Relationship Between Ubiquitin-Specific Peptidase 18 and Hypertension in Polish Adult Male Subjects: A Cross-Sectional Pilot Study.

Med Sci Monit 2020 Jun 12;26:e921919. Epub 2020 Jun 12.

Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

BACKGROUND Arterial hypertension (HT) is a leading cause of cardiac hypertrophy and heart failure. Ubiquitin-specific peptidase 18 (USP18) has been recently described as a factor that prevents myocardial dysfunction. The present study measured serum USP18 levels in normotensive (n=29), isolated diastolic hypertensive (n=20), and systolic-diastolic hypertensive (n=30) male participants and correlated these results with biochemical parameters that are included in routine assessments of patients with hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.921919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305785PMC

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial.

BMJ 2020 06 10;369:m1731. Epub 2020 Jun 10.

Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Objective: To test a scalable health system intervention to improve long term adherence to secondary prevention treatments among patients who have had a recent myocardial infarction.

Design: Three arm, pragmatic randomised controlled trial with blinded outcome assessment.

Setting: Nine cardiac centres in Ontario, Canada. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.m1731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284284PMC

Viral infections and atherothrombosis: Another caution in the wake of COVID-19?

Rev Assoc Med Bras (1992) 2020 03;66(3):366-369

. Departamento de Aterosclerose - Instituto do Coração (InCor) - HCFMUSP, São Paulo, SP, Brasil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1806-9282.66.3.366DOI Listing

Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults.

Rev Assoc Med Bras (1992) 2020 Mar;66(3):268-274

. Programa de Pós-Graduação em Saúde Coletiva, Universidade do Vale do Rio dos Sinos, São Leopoldo, RS, Brasil.

Objective: To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD).

Methods: A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1806-9282.66.3.268DOI Listing