182,334 results match your criteria Arteriosclerosis Thrombosis And Vascular Biology[Journal]


Pro- and anti-inflammatory factors, vascular stiffness and outcomes in chronic hemodialysis patients.

Physiol Int 2020 Jul 2. Epub 2020 Jul 2.

1FMC Dialysis Center Pécs, Pécs, Hungary.

Objective: In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them to pro-inflammatory and protective factors.

Patients: 96 consecutive patients receiving regular HD were included. 20 adult patients without major renal, cardiovascular or metabolic morbidities served as controls. Read More

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http://dx.doi.org/10.1556/2060.2020.00026DOI Listing

Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.

Alcohol Clin Exp Res 2020 Jul 3. Epub 2020 Jul 3.

From the Columbia University Mailman School of Public Health, New York, New York.

Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to cardiovascular disease (CVD), the leading cause of death for men and women in the United States and of global mortality. This study examined associations between reductions in WHO risk drinking levels and subsequent risk for CVD.

Methods: In a US national survey, 1,058 very-high-risk and high-risk drinkers participated in Wave 1 interviews (2001 to 2002) and Wave 2 follow-ups (2004 to 2005). Read More

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http://dx.doi.org/10.1111/acer.14386DOI Listing

Effects of Evening-Only Low-Carbohydrate Meal on Healthy Volunteers.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):229-236

Graduate School of Nursing and Nutrition, Tenshi College.

We performed a pre/post-interventional study with participants as self-controls to evaluate the effects of consuming an evening-only low-carbohydrate meal (LCM) at 1800 h on biochemical measures of glucose and lipid metabolism. Study participants comprised 14 healthy men (age range, 20-29 y) who, consumed standard test meals (STMs) or LCM at 1800 h. Blood samples were collected at fasting, and at 60-, 120-, and 240 min after the start of the meals. Read More

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http://dx.doi.org/10.3177/jnsv.66.229DOI Listing
January 2020

The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):213-218

Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University.

Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions. Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70. Read More

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http://dx.doi.org/10.3177/jnsv.66.213DOI Listing
January 2020

Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study.

Clin Interv Aging 2020 4;15:853-863. Epub 2020 Jun 4.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Purpose: There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship. Read More

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http://dx.doi.org/10.2147/CIA.S248816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283487PMC

Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients.

Int J Mol Sci 2020 Jun 28;21(13). Epub 2020 Jun 28.

Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.

microRNAs (miRNAs) are small RNAs that regulate different biological processes. Our objective was to identify miRNAs dysregulated in plasma and tissue of patients with abdominal aortic aneurysm (AAA) and explore new potential targets involved in AAA. Fifty-seven subjects were recruited for a plasma study (30 AAA patients, 16 healthy volunteers and 11 patients with atherosclerosis). Read More

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http://dx.doi.org/10.3390/ijms21134600DOI Listing

New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular Index (CAVI).

J Atheroscler Thromb 2020 Jun 26. Epub 2020 Jun 26.

Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center.

Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness from the origin of the aorta to the ankle, was developed in 2004. An important feature of this index is the independency from blood pressure at the time of measurement. Read More

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http://dx.doi.org/10.5551/jat.RV17043DOI Listing

Role of Neuronal Nitric Oxide Synthase on Cardiovascular Functions in Physiological and Pathophysiological States.

Nitric Oxide 2020 Jun 23. Epub 2020 Jun 23.

Chapman University and University of California, Irvine, CA, USA. Electronic address:

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on the central nervous system, particularly on brain regions such as the ventrolateral medulla (VLM) and the periaqueductal gray matter (PAG), and on blood vessels and the heart that are involved in the regulation and control of the cardiovascular system (CVS). Furthermore, we shall also review the functional aspects of nNOS during several physiological, pathophysiological, and clinical conditions such as exercise, pain, cerebral vascular accidents or stroke and hypertension. For example, during stroke, a cascade of molecular, neurochemical, and cellular changes occur that affect the nervous system as elicited by generation of free radicals and nitric oxide (NO) from vulnerable neurons, perioxide formation, superoxides, apoptosis, and the differential activation of three isoforms of nitric oxide synthases (NOSs), and can exert profound effects on the CVS. Read More

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http://dx.doi.org/10.1016/j.niox.2020.06.004DOI Listing

[Acral ischaemia with multiple microthromboses and imminent gangrene in a 73-year-old woman with COVID-19].

Ugeskr Laeger 2020 Jun;182(26)

This is a report of an atypical presentation of COVID-19. The patient had sparse pulmonary symptoms despite characteristic COVID-19 lesions on CT-thorax and developed severe acral ischaemic change, after a few days of hospitalisation. The condition could not be explained by classical sepsis with hypotension and hypoperfusion, disseminated intravascular coagulation, vasculitis, endocarditis or severe peripheral arteriosclerosis. Read More

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The relationship between neutrophil-lymphocyte ratio and in-stent restenosis in superficial femoral artery.

Biosci Rep 2020 Jul;40(7)

Department of Intervention,The fourth affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

The present study aimed to investigate the relationship between an increase in the pre- and post-operative neutrophil-lymphocyte ratio (NLR) and superficial femoral artery in-stent restenosis (ISR) rate. We recruited 199 patients that underwent superficial femoral artery stenting for lower extremity arteriosclerosis obliterans at our hospital from March 2015 to July 2018. Patients were divided into two groups according to the occurrence of ISR within 1 year (group 1, ISR and group 2, Non-ISR). Read More

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http://dx.doi.org/10.1042/BSR20193448DOI Listing

Twelve months of exercise training did not halt abdominal aortic calcification in patients with CKD - a sub-study of RENEXC-a randomized controlled trial.

BMC Nephrol 2020 Jun 22;21(1):233. Epub 2020 Jun 22.

Department of Clinical Sciences Lund, Nephrology, Lund, Sweden, Lund University, Skåne University Hospital, Alwallhuset Barngatan 2A, 121 85, Lund, Sweden.

Background: Arteriosclerosis is prevalent in patients with chronic kidney disease (CKD). Our aims were to investigate (1) the effects of 12 months of either balance- or strength- both in combination with endurance training on abdominal aortic calcification (AAC); on some lipids and calcific- and inflammatory markers; and (2) the relationships between the change in AAC score and these markers in non-dialysis dependent patients with CKD stages 3 to 5.

Methods: One hundred twelve patients (mean age 67 ± 13 years), who completed 12 months of exercise training; comprising either balance- or strength training, both in combination with endurance training; with a measured glomerular filtration rate (mGFR) 22. Read More

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http://dx.doi.org/10.1186/s12882-020-01881-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310004PMC

Cholesterol in Relation to COVID-19: Should We Care about It?

J Clin Med 2020 Jun 18;9(6). Epub 2020 Jun 18.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz (MUL), Zeromskiego 113, 90-549 Lodz, Poland.

Current data suggest that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease-19 (COVID-19) seems to follow a more severe clinical course in patients with cardiovascular disease (CVD), hypertension, and overweight/obesity. It appears that lipid-lowering pharmacological interventions, in particular statins, might reduce the risk of cardiovascular complications caused by COVID-19 and might potentially have an additional antiviral activity. It has been shown that high cholesterol levels are associated with more lipid rafts, subdomains of the plasma membrane that can harbour angiotensin-converting enzyme 2 (ACE2) receptors for the S-protein of SARS-CoV-2. Read More

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http://dx.doi.org/10.3390/jcm9061909DOI Listing

Quantitative Histogram Analysis on Intracranial Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging Study.

Stroke 2020 Jul 17;51(7):2161-2169. Epub 2020 Jun 17.

Department of Radiology (Z.S., J. Li, W.P., T.J., Q.L., J. Lu), Changhai Hospital, Naval Medical University, Shanghai, China.

Background And Purpose: Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events. This study aims to evaluate differences in histogram features between culprit and nonculprit intracranial atherosclerosis using high-resolution magnetic resonance imaging.

Methods: Two hundred forty-seven patients with intracranial atherosclerosis who underwent high-resolution magnetic resonance imaging sequentially between January 2015 and December 2016 were recruited. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029062DOI Listing
July 2020
5.723 Impact Factor

Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.

Mol Biol Rep 2020 Jun 21. Epub 2020 Jun 21.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

The oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a pivotal role in the initiation and progression of atherosclerosis which is a complex and progressive disorder. Paraoxonase1 (PON1), which is required for lipid metabolism, is believed to protect LDL from oxidation. The relationship between PON1 gene Leusin55Methionin (L55M) and Glutamine192Arginine (Q192R) polymorphisms in western Iranians with atherosclerosis and its association with enzyme activity and oxidized low-density lipoprotein (oxLDL) were examined in the present study. Read More

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http://dx.doi.org/10.1007/s11033-020-05585-2DOI Listing
June 2020
2.024 Impact Factor

Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans.

PeerJ 2020 11;8:e9305. Epub 2020 Jun 11.

Department of Vascular Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Objectives: This study set out to analyze the difference of heat shock protein 27 (HSP27) and its phosphorylation in patients with lower extremity arteriosclerosis obliterans (LEASO) at different stages. This research also examined their clinical significance in this disease.

Methods: Blood samples from 60 patients with LEASO were collected and divided into two groups according to ankle-brachial index (ABI): group A (ABI ≤ 0. Read More

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http://dx.doi.org/10.7717/peerj.9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293856PMC

Feasibility, Safety, and Effectiveness of a Mobile Application in Cardiac Rehabilitation.

Isr Med Assoc J 2020 06;22(6):357-363

Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, Tel Hashomer, Israel.

Background: Cardiac rehabilitation (CR) is underutilized globally despite evidence of clinical benefit. Major obstacles for wider adoption include distance from the rehabilitation center, travel time, and interference with daily routine. Tele-cardiac rehabilitation (tele-CR) can potentially address some of these limitations, enabling patients to exercise in their home environment or community. Read More

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[Antithrombotic treatments in patients with SARS-CoV-2 infection: from current evidence to reasonable recommendations - A position paper from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology].

G Ital Cardiol (Rome) 2020 Jul;21(7):489-501

Dipartimento Cardiovascolare-AUSL Romagna, U.O. Cardiologia, Ospedale S. Maria delle Croci, Ravenna.

Given the high prevalence of preexisting cardiovascular diseases and the increased incidence of adverse cardiovascular events in patients hospitalized for SARS-CoV-2 infection, the identification of optimal antithrombotic approaches in terms of risk/benefit ratio and outcome improvement appears crucial in this setting. In the present position paper we collected current evidence from the literature to provide practical recommendations on the management of antithrombotic therapies (antiplatelet and anticoagulant) in various clinical contexts prevalent during the SARS-CoV-2 outbreak: in-home management of oral anticoagulant therapy; interactions between drugs used in the SARS-CoV-2 infection and antithrombotic agents; in-hospital management of antithrombotic therapies; diagnosis, risk stratification and treatment of in-hospital thrombotic complications. Read More

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http://dx.doi.org/10.1714/3386.33634DOI Listing

Epidemiological investigation of infection in elderly people in Beijing.

World J Clin Cases 2020 Jun;8(11):2173-2180

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The () infection rate in China is approximately 50%. is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281052PMC

Association between Plasma Adipocytokines Levels and Intracranial versus Extracranial Atherosclerotic among Chinese Patients with Stroke.

Iran J Public Health 2020 Apr;49(4):645-653

Department of Neurology, PLA 254 Hospital, Tianjin300141, P.R.China.

Background: To detect the levels of plasma Adipocytokines, TNF-α, IL-6 and PAI-1 in patients with intracranial and extracranial arteriosclerosis.

Methods: From September 2015 to September 2017, 318 patients aged ≥60 years were enrolled. Overall, 192 patients were included in the case group (intracranial and extracranial arteriosclerosis group). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283181PMC

The Background of Calculating CAVI: Lesson from the Discrepancy Between CAVI and CAVI.

Vasc Health Risk Manag 2020 21;16:193-201. Epub 2020 May 21.

Mihama Hospital, Chiba, Japan.

Arterial stiffness is a good predictor of cardiovascular events. As a substitute for elastic modulus representing stiffness, pulse wave velocity (PWV) has been used for over a century as it is easy to measure; however, PWV is known to essentially depend on blood pressure at the time of measurement. The cardio-ankle vascular index (CAVI) is a relatively new index of global arterial stiffness of the origin of the aorta to the ankle arteries. Read More

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http://dx.doi.org/10.2147/VHRM.S223330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251085PMC

Coronary revascularization after heart transplant - the search for prognostic factors.

Arch Med Sci 2020 18;16(4):789-795. Epub 2020 Apr 18.

Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

Introduction: Survival after heart transplantation (HTX) is extended due to continuous improvement of medical care, allowing enough time for coronary artery vasculopathy to develop. Data on the clinical outcome of cardiac transplantation patients after percutaneous coronary intervention (PCI) are still not extensively explored. The aim of our study was to assess whether heart transplantation itself compromises the outcome in patients undergoing percutaneous coronary intervention and to assess survival rates as well as major cardiovascular complications in heart transplant recipients who had undergone PCI. Read More

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http://dx.doi.org/10.5114/aoms.2017.71847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286336PMC

Effects of Valsartan on Restenosis in Patients with Arteriosclerosis Obliterans of the Lower Extremities Undergoing Interventional Therapy: A Prospective, Randomized, Single-Blind Trial.

Med Sci Monit 2020 Jun 16;26:e919977. Epub 2020 Jun 16.

Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province, Cangzhou, Hebei, China (mainland).

BACKGROUND The aim of this study was to further clarify the effects of valsartan on restenosis in patients with arteriosclerosis obliterans of the lower extremities. MATERIAL AND METHODS Patients with arteriosclerosis obliterans of the lower extremities undergoing continuous stent implantation in the superficial femoral artery were enrolled and randomly divided into an ARB group and a control group. Patients in the ARB group received valsartan orally in a single-blind manner and were followed up for 6 months. Read More

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http://dx.doi.org/10.12659/MSM.919977DOI Listing

Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status.

J Am Heart Assoc 2020 Jun 13:e017288. Epub 2020 Jun 13.

Marshall University Huntington WV.

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http://dx.doi.org/10.1161/JAHA.120.017288DOI Listing

The important role of histone deacetylases in modulating vascular physiology and arteriosclerosis.

Atherosclerosis 2020 Jun 22;303:36-42. Epub 2020 May 22.

University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Cardiovascular diseases are the leading cause of deaths in the world. Endothelial dysfunction followed by inflammation of the vessel wall leads to atherosclerotic lesion formation that causes ischemic heart and myocardial hypertrophy, which ultimately progress into cardiac dysfunction and failure. Histone deacetylases (HDACs) have been recognized to play crucial roles in cardiovascular disease, particularly in the epigenetic regulation of gene transcription in response to a variety of stresses. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.04.020DOI Listing
June 2020
3.994 Impact Factor

Hepatoma-derived growth factor enhances osteoblastic transformation of rat aortic vascular smooth muscle cells in vitro.

Life Sci 2020 Jun 11;256:117964. Epub 2020 Jun 11.

Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan. Electronic address:

Aims: Vascular smooth muscle cells (VSMCs) are important regulators of vascular functions and their conversion to osteoblasts is a key to development of vascular calcification. This study aimed to characterize in vitro effect of hepatoma-derived growth factor (HDGF) on phenotypic conversion of cultured aortic VSMCs into osteoblast-like cells.

Materials And Methods: Cell proliferation and migration assays were used to examine cell behaviors. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117964DOI Listing

A Case Report of Werner's Syndrome With a Novel Mutation From India.

Cureus 2020 May 8;12(5):e8025. Epub 2020 May 8.

Pathology, University of Washington, Seattle, USA.

Werner's syndrome (WS) or progeria adultorum is a heritable autosomal recessive disease in which the aging process is accelerated, just after puberty. It is caused by mutations in the WRN gene, which encodes a member of the RECQ family of DNA helicases and has a role in DNA repair. WS is being more appropriately recognized as a condition in which the lack of WRN protein results in an overall decline in the normal physiological functions of various organs rather than premature aging. Read More

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http://dx.doi.org/10.7759/cureus.8025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380PMC

Relationship Between Ubiquitin-Specific Peptidase 18 and Hypertension in Polish Adult Male Subjects: A Cross-Sectional Pilot Study.

Med Sci Monit 2020 Jun 12;26:e921919. Epub 2020 Jun 12.

Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

BACKGROUND Arterial hypertension (HT) is a leading cause of cardiac hypertrophy and heart failure. Ubiquitin-specific peptidase 18 (USP18) has been recently described as a factor that prevents myocardial dysfunction. The present study measured serum USP18 levels in normotensive (n=29), isolated diastolic hypertensive (n=20), and systolic-diastolic hypertensive (n=30) male participants and correlated these results with biochemical parameters that are included in routine assessments of patients with hypertension. Read More

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http://dx.doi.org/10.12659/MSM.921919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305785PMC

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial.

BMJ 2020 06 10;369:m1731. Epub 2020 Jun 10.

Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Objective: To test a scalable health system intervention to improve long term adherence to secondary prevention treatments among patients who have had a recent myocardial infarction.

Design: Three arm, pragmatic randomised controlled trial with blinded outcome assessment.

Setting: Nine cardiac centres in Ontario, Canada. Read More

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http://dx.doi.org/10.1136/bmj.m1731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284284PMC

Viral infections and atherothrombosis: Another caution in the wake of COVID-19?

Rev Assoc Med Bras (1992) 2020 03;66(3):366-369

. Departamento de Aterosclerose - Instituto do Coração (InCor) - HCFMUSP, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/1806-9282.66.3.366DOI Listing

Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults.

Rev Assoc Med Bras (1992) 2020 Mar;66(3):268-274

. Programa de Pós-Graduação em Saúde Coletiva, Universidade do Vale do Rio dos Sinos, São Leopoldo, RS, Brasil.

Objective: To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD).

Methods: A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0. Read More

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http://dx.doi.org/10.1590/1806-9282.66.3.268DOI Listing

Assessment of Periodontal Status Based on Carotid Artery Intima Media Thickness.

Oral Health Prev Dent 2020 ;18(3):511-519

Purpose: Atherosclerosis is a devastating disease worldwide since it is the most frequent cause of myocardial infarction, stroke, renal failure, peripheral vascular disease and perhaps dementia. There is a well-documented evidence supporting the association between clinical/subclinical atherosclerosis and periodontitis. Carotid intima media wall thickness (CIMT) is a histopathologically validated marker of atherosclerosis. Read More

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http://dx.doi.org/10.3290/j.ohpd.a44036DOI Listing

Endothelial Cell Morphology Regulates Inflammatory Cells Through MicroRNA Transferred by Extracellular Vesicles.

Front Bioeng Biotechnol 2020 19;8:369. Epub 2020 May 19.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Med-X Research Institution, Shanghai Jiao Tong University, Shanghai, China.

Vascular inflammation plays an important role in the pathogenesis and the development of cardiovascular diseases such as arteriosclerosis and restenosis, and the dysfunction of endothelial cells (ECs) may result in the activation of monocytes and other inflammatory cells. ECs exhibit an elongated morphology in the straight part of arteries but a cobblestone shape near the pro-atherogenic region such as branch bifurcation. Although the effects of hemodynamic forces on ECs have been widely studied, it is not clear whether the EC morphology affects its own function and thus the inflammatory response of monocytes. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248333PMC

Establishing normal reference value of carotid ultrafast pulse wave velocity and evaluating changes on coronary slow flow.

Int J Cardiovasc Imaging 2020 Jun 6. Epub 2020 Jun 6.

Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Shenyang, Liaoning, 110001, People's Republic of China.

Pulse wave velocity (PWV) measured by ultrafast ultrasound imaging can early evaluate arteriosclerosis. The study aimed to establish normal reference range for ufPWV in healthy adults and explore its influencing factors, and evaluate the ufPWV changes on coronary slow flow (CSF). ufPWV at the beginning and end of systole (ufPWV-BS and ufPWV-ES, respectively) was measured in healthy adults (201 cases). Read More

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http://dx.doi.org/10.1007/s10554-020-01908-3DOI Listing

The effect of a lifestyle management educational program on blood pressure, heart rate, and body mass index in patients with hypertension.

ARYA Atheroscler 2020 Jan;16(1):7-15

Assistant Professor, Hypertension Research Center, Cardiovascular Research Institute AND Department of Intensive Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hypertension (HTN) is one of the most prevalent risk factors for arteriosclerosis and coronary artery disease (CAD). Its side effects can be decreased through the use of some methods and interventions. The present study was conducted with the aim to evaluate the effects of a lifestyle management on blood pressure, heart rate, and body mass index (BMI) of patients with HTN who have undergone angioplasty. Read More

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http://dx.doi.org/10.22122/arya.v16i1.1502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244792PMC
January 2020

[Chronic coronary syndrome (stable coronary artery disease) : Indication to revascularization in 2020 and latest evidence].

Rev Med Suisse 2020 Jun;16(696):1140-1146

Service de cardiologie, Département cœur et vaisseaux, CHUV et Université de Lausanne, 1011 Lausanne.

The decision to perform coronary revascularization in the setting of chronic coronary syndrome is based on the detection of myocardial ischemia through non-invasive or invasive tests, according to the cardiovascular risk of each patient. This latter will also determine the benefit to be expected with revascularization. The present article is a brief summary of the latest evidence in this domain. Read More

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LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models.

Circ Res 2020 Jun 4. Epub 2020 Jun 4.

Biochemistry, IIB Sant Pau, SPAIN.

The HDL-mediated stimulation of cellular cholesterol efflux initiates the reverse cholesterol pathway from macrophages (m-RCT), which ends in the fecal excretion of macrophage-derived unesterified cholesterol (UC). Early studies established that LDL particles could act as efficient intermediate acceptors of cellular-derived UC, thereby preventing the saturation of HDL particles and facilitating their cholesterol efflux capacity (CEC). However, the capacity of LDL to act as a plasma cholesterol reservoir and its potential impact in supporting the m-RCT pathway in vivo both remain unknown. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316424DOI Listing

Extracranial carotid artery aneurysm with myeloproliferative neoplastic cell invasion.

J Vasc Surg Cases Innov Tech 2020 Jun 28;6(2):243-246. Epub 2020 May 28.

Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan.

The major causes of rare extracranial carotid artery aneurysms are arteriosclerosis, trauma, and radiation therapy. Here, we describe a patient with an extracranial carotid artery aneurysm caused by a myeloproliferative neoplasm. A 67-year-old woman underwent excision of an irregularly shaped aneurysm in the left common carotid artery and a saphenous vein graft without major complications. Read More

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http://dx.doi.org/10.1016/j.jvscit.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261954PMC

Single Tertiary Care Center Outcomes After Lower Extremity Cadaveric Vein Bypass for Limb Salvage.

Vasc Endovascular Surg 2020 Jul;54(5):430-435

Staten Island University Hospital, Staten Island, NY, USA.

Objective: Cadaveric saphenous vein (CV) conduits are used in rare instances for limb salvage in patients without autogenous veins although long-term outcome data are scarce. This study was designed to evaluate the outcomes of CV bypass in patients with threatened limbs.

Methods: We retrospectively reviewed the charts from 2010 to 2017 of 25 patients who underwent 30 CV allografts for critical limb ischemia and acute limb ischemia. Read More

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http://dx.doi.org/10.1177/1538574420925586DOI Listing
July 2020
0.766 Impact Factor

Reply to P-F Wu et al.

Authors:
Pinpin Long An Pan

Am J Clin Nutr 2020 06;111(6):1300-1301

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1093/ajcn/nqaa070DOI Listing

Application and interpretation of Mendelian randomization approaches in exploring the causality between folate and coronary artery disease.

Am J Clin Nutr 2020 06;111(6):1299-1300

Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1093/ajcn/nqaa069DOI Listing

Identification and tissue-specific expression of rutin biosynthetic pathway genes in Capparis spinosa elicited with salicylic acid and methyl jasmonate.

Sci Rep 2020 Jun 1;10(1):8884. Epub 2020 Jun 1.

Department of Plant Breeding, Swedish University of Agricultural Sciences, Växtskyddsvägen 1, SE-230 53, Alnarp, Sweden.

Capparis spinosa is an edible medicinal plant which is considered as an excellent source of rutin. Rutin is a glycoside of the flavonoid quercetin that has been reported to have a beneficial role in controlling various diseases such as hypertension, arteriosclerosis, diabetes, and obesity. In this study, the partial cDNA of four genes involved in the rutin biosynthetic pathway including 4-coumaroyl CoA ligase (4CL), flavonoid 3'-hydroxylase (F3'H), flavonol synthase (FLS) and flavonol-3-O-glucoside L-rhamnosyltransferase (RT) were identified in C. Read More

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http://dx.doi.org/10.1038/s41598-020-65815-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264309PMC

Association of CYP4F2 and CTRP9 polymorphisms and serum selenium levels with coronary artery disease.

Medicine (Baltimore) 2020 May;99(22):e20494

Cardiovascular Disease Center, Central Hospital of Enshi Autonomous Prefecture, Enshi, China.

Aims to explore the interaction between serum selenium level and CYP4F2 and CTRP9 gene polymorphisms in the development of coronary artery disease (CAD).A total of 200 cases of CAD were selected from the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei, China, and 200 healthy subjects cases were served as controls. The polymorphism of CYP4F2 and CTRP9 gene was detected by Sanger sequencing, and the serum selenium level was measured by hydride generation atomic fluorescence spectrometry. Read More

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http://dx.doi.org/10.1097/MD.0000000000020494DOI Listing

Expression and clinical significance of serum cystatin C in patients with hypertension and coronary heart disease.

Medicine (Baltimore) 2020 May;99(22):e20029

NingBo First Hospital, Ningbo, Zhejiang, China.

The aim of this study is to explore the potential association between cystatin C (Cys-c) and coronary heart disease (CHD) in hypertensive patients.In this study, circulating levels of Cys-c in 62 essential hypertension (EH) patients, 147 hypertension with coronary heart disease (EH + CHD) patients, and 60 healthy volunteers were investigated using immunoturbidimetry. Then, we analyzed the correlations between Cys-C and other clinical parameters. Read More

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http://dx.doi.org/10.1097/MD.0000000000020029DOI Listing

In silico analysis of the molecular regulatory networks in peripheral arterial occlusive disease.

Medicine (Baltimore) 2020 May;99(21):e20404

Department of Vascular Intervention.

Background: Peripheral arterial occlusive disease (PAOD) is a global public health concern that decreases the quality of life of the patients and can lead to disabilities and death. The aim of this study was to identify the genes and pathways associated with PAOD pathogenesis, and the potential therapeutic targets.

Methods: Differentially expressed genes (DEGs) and miRNAs related to PAOD were extracted from the GSE57691 dataset and through text mining. Read More

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http://dx.doi.org/10.1097/MD.0000000000020404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250035PMC

Comparison of coronary artery bypass grafting and percutaneous coronary intervention for syphilitic coronary artery ostial lesions: A 4-year retrospective study.

Medicine (Baltimore) 2020 May;99(21):e20104

Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, Fujian, China.

This study investigated the efficacy of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in treatment of patients with syphilitic coronary artery ostial lesions (SCAOL).Sixty SCAOL patients were divided into two groups according to the different treatments: the CABG group (n = 32) and the PCI group (n = 28). We determined serum levels of β-type natriuretic peptide (BNP) and cardiac function, and evaluated treatment efficacy such as the rates of restenosis, patency, and major adverse cardiovascular events (MACEs) during hospital stay and the effects of antisyphilis and different types of CABG on restenosis during the 6-month follow-up period. Read More

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http://dx.doi.org/10.1097/MD.0000000000020104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249995PMC
May 2020
5.723 Impact Factor

The effect of Shexiang Tongxin Dropping Pills on coronary microvascular dysfunction (CMVD) among those with a mental disorder and non-obstructive coronary artery disease based on stress cardiac magnetic resonance images: A study protocol.

Medicine (Baltimore) 2020 May;99(21):e20099

Department of Cardiology.

Introduction: Coronary microvascular dysfunction (CMVD), highly prevalent among patients with a mental disorder (anxiety or depression), is closely related to adverse cardiac events, including hospitalization, sudden cardiac death, and myocardial infarction. Shexiang Tongxin Dropping Pills (STDP), a traditional Chinese medicine, exerts endothelial protective function by anti-inflammation, anti-oxidative stress, and promoting blood circulation. STDP protects against CMVD in previous fundamental studies. Read More

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http://dx.doi.org/10.1097/MD.0000000000020099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249860PMC

Antiatherosclerotic Activity of Eriocitrin in High-Fat-Diet-Induced Atherosclerosis Model Rats.

J Environ Pathol Toxicol Oncol 2020 ;39(1):61-75

Department of General Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.

Atherosclerosis is a multifactorial disease that develops and progresses in the arterial wall in response to a variety of stimuli. Among various other stimuli, hyperlipidemia is an extremely important factor that is correlated with the development of atherosclerosis. Lemon and citrus fruits contain various bioactive flavonoids, such as eriocitrin, that prevent obesity and related metabolic diseases. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2020031478DOI Listing

Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets.

Front Cardiovasc Med 2020 12;7:79. Epub 2020 May 12.

Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life. We have shown that skeletal muscle abnormalities are a hallmark of HF, in which metabolic pathways involving phosphocreatine and fatty acids are largely affected. Not only in HF, but the dysfunction of fatty acid metabolism may also occur in many chronic diseases, such as arteriosclerosis, as well as through insufficient physical exercise. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235191PMC

Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes.

Diabetol Metab Syndr 2020 20;12:44. Epub 2020 May 20.

1Department of Endocrinology, Affiliated Hospital 2 of Nantong, University and First People's Hospital of Nantong City, No. 6 North Hai‑er‑xiang Road, Nantong, 226001 China.

Background: The role of serum fibroblast growth factor 19 (FGF19) in arteriosclerosis is not well known. In the present study, we aimed to explore whether serum FGF19 levels were related to arteriosclerosis parameters, including arterial stiffness and atherogenic index of plasma (AIP), in patients with type 2 diabetes (T2D).

Methods: A total of 200 patients with type 2 diabetes and 50 healthy controls were recruited for this study from Apr 2017 to Oct 2018. Read More

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http://dx.doi.org/10.1186/s13098-020-00552-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240909PMC
May 2020
2.500 Impact Factor