190,389 results match your criteria Arteriosclerosis Thrombosis And Vascular Biology[Journal]

The relationship between brachial-ankle pulse wave velocity and peripheral blood lymphocyte subsets in hypertensives: a cross-sectional study.

J Hum Hypertens 2021 Jun 11. Epub 2021 Jun 11.

Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Arteriosclerosis is the common pathological basis of hypertension-related target organ damage, and pulse wave velocity (PWV) is commonly used to assess the degree of arterial stiffness. Previous studies have reported the correlation between peripheral blood inflammatory indicators and PWV in hypertensives, but few studies examined the role of immune cells in arteriosclerosis in the context of human hypertension. In order to enrich the understanding of this topic, we conducted a cross-sectional study on hospitalized hypertensives in Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology from January 2015 to February 2017 to investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and peripheral blood lymphocyte subsets. Read More

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Pachychoroid Spectrum Disease: Underlying Pathology, Classification, and Phenotypes.

Curr Eye Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Pachychoroid spectrum disease encompasses a set of macular disorders secondary to an abnormally thick choroid. However, the pathological process underlying pachychoroid spectrum disease and its overlap with age-related macular degeneration (AMD) remain unclear. This review aimed to understand the underlying pathology, classification, and phenotypes of pachychoroid spectrum disease. Read More

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Remote and Anesthetic-Induced Myocardial Preconditioning Is Preserved in Atherosclerotic LDL Receptor-/- Mice In Vivo.

Cardiovasc Ther 2021 24;2021:5596590. Epub 2021 May 24.

Department of Anesthesiology, Amberg Hospital, Mariahilfbergweg 7, 92224 Amberg, Germany.

Introduction: In the animal model, preconditioning is a powerful weapon against ischemic damage. The reason why the human heart cannot be protected from ischemic damage by preconditioning remains unclear. There are assumptions that the lack of preconditioning in humans is caused by concomitant diseases such as dyslipoproteinemia and arteriosclerosis. Read More

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TET2 Protects Against VSMC Apoptosis and Intimal Thickening in Transplant Vasculopathy.

Circulation 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine (Cardiovascular Medicine), Yale University School of Medicine, New Haven, CT.

Coronary allograft vasculopathy (CAV) is a devastating sequelae of heart transplant in which arterial intimal thickening limits coronary blood flow. There are currently no targeted therapies to prevent or reduce this pathology that leads to transplant failure. Vascular smooth muscle cell (VSMC) phenotypic plasticity is critical in CAV neointima formation. Read More

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Autopsy-Determined Atherosclerosis in Elite US Military Special Operations Forces.

J Spec Oper Med 2021 ;21(2):19-24

Background: Autopsy studies of trauma fatalities have provided evidence for the pervasiveness of atherosclerosis in young and middle-aged adults. The objective of this study was to determine the prevalence of atherosclerosis in elite US military forces.

Methods: We conducted a retrospective study of all US Special Operations Command (USSOCOM) fatalities from 2001 to 2020 who died from battle injuries. Read More

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Georgian Med News 2021 Apr(313):98-101

Tbilisi State Medical University, Department of Internal Disease of Propedeutics, Georgia.

The purpose of this study was to determine the efficacy and safety of statins in improving cognitive function in patients with vascular dementia. As the most important etiological factors of the disease are atherosclerotic vascular lesions, one of the important areas of treatment is lipid metabolism analysis and drug treatment for dyslipidemia. 31 patients were selected for the study, ages 65-65 years, 18 males, 13 females. Read More

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[Roles of periodontal pathogens in the pathogenesis of atherosclerosis].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):584-590

Department of Periodontics, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Periodontitis is closely related to systemic health, especially cardiovascular disease. Periodontal pathogens from periodontal infection actively participate in the formation and development of coronary atherosclerosis. At present, accumulcted evidences show that periodontal pathogen infection is an independent risk factor for cardiovascular events, which promotes the deepening of atherosclerosis through a variety of immune inflammation and metabolism-related molecular mechanisms. Read More

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A kidney discard decision strategy based on zero-time histology analysis could lead to an unjustified increase in the organ turndown rate among ECD.

Transpl Int 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

The utility of zero-time kidney biopsies (KB) in deciding to accept expanded criteria donor (ECD) kidneys remains controversial. However, zero-time histology is one of the main causes for discarding kidneys in the US. In a single-centre study we examined the utility and impact on outcome of the use of frozen section zero-time KB among ECD. Read More

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MicroRNA-125b inhibits the proliferation of vascular smooth muscle cells induced by platelet-derived growth factor BB.

Exp Ther Med 2021 Aug 24;22(2):791. Epub 2021 May 24.

Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China.

Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) is the main cause of arteriosclerosis obliterans (ASO). The present study aimed to investigate the role of microRNA (miR)-125b on the proliferation and migration of VSMCs. Platelet-derived growth factor-BB (PDGF-BB; 20 ng/ml) was used to treat VSMCs to establish an model of ASO. Read More

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Arteriosclerosis and other diseases in heads of government and its consequences for the population.

Rafael Carmena

Clin Investig Arterioscler 2021 Jun 3. Epub 2021 Jun 3.

Catedrático Emérito de Medicina, Departamento de Medicina, Universidad de Valencia, Valencia, España. Electronic address:

Heads of government with cerebrovascular arteriosclerosis and other diseases in key historical moments have led to decisions that have marked the destiny of countries not always in a beneficial direction. Severe diseases in political leaders in power have often been hidden from citizens with the collaboration of personal physicians. The confidentiality of the patient-doctor relationship in special political circumstances should be reexamined and subjected to debate. Read More

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Frequency, intensity and duration of routine rehabilitation exercises practiced by patients with coronary artery disease.

J Pak Med Assoc 2021 May;71(5):1399-1402

University of Lahore, Raiwind Campus, Lahore, Pakistan.

Objective: To determine the frequency, intensity and duration of routine rehabilitation exercises practiced by patients with coronary artery disease.

Methods: The cross-sectional descriptive study was conducted from February to June 2019 in different hospitals of Lahore, Pakistan, and comprised coronary artery disease patients of either gender aged 35-65 years. Data was collected using an interview-based questionnaire. Read More

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Monckeberg's Medial Sclerosis as a Cause for Headache and Facial Pain.

Curr Pain Headache Rep 2021 Jun 4;25(8):50. Epub 2021 Jun 4.

Professional Program for International Dentists, University of California Los A ngeles School of Dentistry, Los Angeles, CA, USA.

Purpose Of Review: Mönckeberg's medial sclerosis (MMS) is a chronic, non-inflammatory degenerative condition affecting primarily the tunica media of muscular arteries resulting in their calcification. The purpose of this comprehensive review is to describe MMS as it appears in the literature, in the context of headache and facial pain. Understanding the etiopathology, the associated conditions, and the differential diagnoses is important in managing MMS. Read More

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Shear stress and ROS-responsive biomimetic micelles for atherosclerosis via ROS consumption.

Mater Sci Eng C Mater Biol Appl 2021 Jul 4;126:112164. Epub 2021 May 4.

Key Laboratory of Special Engineering Plastics Ministry of Education, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:

Reactive oxygen species (ROS) are well-known important initiating factors required for atherosclerosis formation, which leads to endothelial dysfunction and plaque formation. Most of the existing antithrombotic therapies use ROS-responsive drug delivery systems, which have a certain therapeutic effect but cannot eliminate excess ROS. Therefore, the atherosclerosis cannot be treated from the source. Read More

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It's a Trap: A Case of Strangulated Coronary Guidewire and Longitudinal Stent Deformation in the Right Coronary Artery.

Am J Case Rep 2021 Jun 3;22:e931058. Epub 2021 Jun 3.

Department of Interventional Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.

BACKGROUND Strangulation of the coronary guidewire is an infrequent complication of percutaneous coronary intervention (PCI), and it can lead to disastrous outcomes of stent thrombosis, vessel occlusion, and vessel damage. CASE REPORT Early-generation stents were made from stainless steel and had a bulky design as compared to cobalt-chromium or platinum chromium alloys, which have superior trackability at the cost of a thin core and low-strength struts, resulting in increased incidence of longitudinal stent deformation. We present a case of a 62-year-old active smoker with effort angina of Canadian Cardiovascular Society (CCS) class III. Read More

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Serum butyrylcholinesterase/HDL-cholesterol ratio and atherogenic index of plasma in patients with fatty liver disease.

Vnitr Lek 2021 ;67(E-2):4-8

Cardiovascular diseases on an atherosclerotic basis are a serious health problem. Atherosclerosis is a multifactorial pathological process with complex pathogenesis. Its origin and development is conditioned by a set of several risk factors. Read More

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SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies.

Biomedicines 2021 May 27;9(6). Epub 2021 May 27.

Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain.

High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein due to its role in reverse cholesterol transport and its ability to receive cholesterol that effluxes from macrophages in the artery wall. The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Read More

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Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging.

Sensors (Basel) 2021 May 19;21(10). Epub 2021 May 19.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA.

As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound transducer mounted catheter into an artery, the vessel lumen opening, vessel wall morphology and other associated blood and vessel properties can be precisely assessed in IVUS imaging. Ultrasound transducer, as the key component of an IVUS system, is critical in determining the IVUS imaging performance. Read More

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A Nano-Emulsion Platform Functionalized with a Fully Human scFv-Fc Antibody for Atheroma Targeting: Towards a Theranostic Approach to Atherosclerosis.

Int J Mol Sci 2021 May 14;22(10). Epub 2021 May 14.

Centre de Résonance Magnétique des Systèmes Biologiques, CNRS UMR 5536, Université de Bordeaux, CRMSB, 33076 Bordeaux, France.

Atherosclerosis is at the onset of the cardiovascular diseases that are among the leading causes of death worldwide. Currently, high-risk plaques, also called vulnerable atheromatous plaques, remain often undiagnosed until the occurrence of severe complications, such as stroke or myocardial infarction. Molecular imaging agents that target high-risk atheromatous lesions could greatly improve the diagnosis of atherosclerosis by identifying sites of high disease activity. Read More

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Alternative C3 Complement System: Lipids and Atherosclerosis.

Int J Mol Sci 2021 May 12;22(10). Epub 2021 May 12.

Cardiovascular Program-ICCC, Research Institute-Hospital Santa Creu i Sant Pau, IIB-Sant Pau, 08025 Barcelona, Spain.

Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque progression remains unknown. The aim of the study was to investigate by a systems biology approach the role of C3 in relation to lipoprotein levels during atherosclerosis (AT) progression and to gain a better understanding on the effects of C3 products on the phenotype and function of human lipid-loaded vascular smooth muscle cells (VSMCs). Read More

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Association of SDF1 and MMP12 with Atherosclerosis and Inflammation: Clinical and Experimental Study.

Life (Basel) 2021 May 1;11(5). Epub 2021 May 1.

Haematology Service, Clínica Universidad de Navarra, 31008 Pamplona, Spain.

Background: Atherosclerosis is the main etiology of cardiovascular diseases (CVD), associated to systemic inflammation. Matrix metalloproteinases (MMPs) are related to atherosclerosis progression through the SDF1/CXCR4 axis promoting macrophages recruitment within the vascular wall. The goal was to assess new circulatory inflammatory markers in relation to atherosclerosis. Read More

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Lower Extremity Ulcers.

Med Clin North Am 2021 Jul;105(4):663-679

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, RMSB, Room 2023-A, USA. Electronic address:

Lower extremity ulcerations contribute to significant morbidity and economic burden globally. Chronic wounds, or those that do not progress through healing in a timely manner, are estimated to affect 6.5 million people in the United States alone causing, significant morbidity and economic burden of at least an estimated $25 billion annually. Read More

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[Inherited premature coronary artery disease: classification and research progress].

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):578-584

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China.

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PCSK9 and cancer: Rethinking the link.

Biomed Pharmacother 2021 May 28;140:111758. Epub 2021 May 28.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Cancer is emerging as a major problem globally, as it accounts for the second cause of death despite medical advances. According to epidemiological and basic studies, cholesterol is involved in cancer progression and there are abnormalities in cholesterol metabolism of cancer cells including prostate, breast, and colorectal carcinomas. However, the importance of cholesterol in carcinogenesis and thereby the role of cholesterol homeostasis as a therapeutic target is still a debated area in cancer therapy. Read More

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Almond protects the liver in coronary artery disease: A randomized controlled clinical trial.

J Pak Med Assoc 2021 Mar;71(3):791-795

The University of Haripur, Khyber Pakhtunkhwa, Pakistan.

Objective: To compare the effect of Pakistani and American almonds on serum concentration of liver enzymes in coronary artery disease patients.

Methods: The randomised controlled trial was conducted at the Cardiology Clinics of Aga Khan University Hospital, Karachi, from February to July, 2012, and comprised patients who were randomised into intervention PA and AA groups and the control NI groups. Subjects in the intervention groups were provided Pakistani and American varieties of almonds 10g/day respectively with instructions to soak them overnight, remove the skin and eat them before breakfast for 12 weeks. Read More

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Successful Retrieval of Entrapped Guide Extension Catheter in the Right Coronary Artery with Heavy Calcifications.

Int Heart J 2021 ;62(3):682-686

Department of Cardiovascular Medicine, Okamura Memorial Hospital.

Usage of an optimal guide extension catheter often helps successful outcomes in complex percutaneous coronary intervention. Here, we report a case of successfully retrieving a guide extension catheter entrapped by a coronary stent in the middle RCA. The guide extension catheter was retrieved by anchoring with the stent delivery balloon. Read More

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Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis.

Cell Death Discov 2021 May 29;7(1):124. Epub 2021 May 29.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

Chronic cerebral ischaemia (CCI) is a common pathological disorder, which is associated with various diseases, such as cerebral arteriosclerosis and vascular dementia, resulting in neurological dysfunction. As a type of non-coding RNA, circular RNA is involved in regulating the occurrence and development of diseases, such as ischaemic brain injury. Here, we found that HT22 cells and hippocampus treated with CCI had low expression of circ_0000296, Runx3, Sirt1, but high expression of miR-194-5p. Read More

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Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences.

Nat Commun 2021 05 27;12(1):3190. Epub 2021 May 27.

School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, United Kingdom.

The hippocampus is essential for spatial and episodic memory but is damaged early in Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its oxygen supply is therefore key for designing interventions to preserve its function. However, studies of neurovascular function in the hippocampus in vivo have been limited by its relative inaccessibility. Read More

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The effect of sedentary time on the results of exercise therapy in patients with peripheral arterial disease complicated with type 2 diabetes.

Ann Palliat Med 2021 May 12;10(5):5366-5372. Epub 2021 May 12.

Department of Pediatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: Peripheral artery disease (PAD) is a common chronic complication of type 2 diabetes (T2DM). This study sought to evaluate the effect of supervised exercise therapy (SET) on patients with PAD complicated with T2DM, and to assess the effect of changes in sedentary time on the results of SET treatment.

Methods: A total of 100 PAD patients who were treated in our hospital from January 2019 to October 2020 were included, and the age, gender, body mass index (BMI), hypertension, smoking, and ankle brachial index (ABI) were collected. Read More

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[The role of neovascularization in the formation of an unstable human atherosclerotic plaque].

Arkh Patol 2021 ;83(3):5-10

Institute of Experimental Medicine, St. Petersburg, Russia.

Material And Methods: The study material was 20 autopsy samples obtained from males aged 65 to 72 years who died from acute atherosclerotic cardiovascular insufficiency. Aortic segments (from the arch, thoracic and abdominal regions), coronary arteries and the arteries of the base of the brain () were investigated; these totaled 45 tissue segments. Neovessels and cellular responses in the arterial wall were examined by hematoxylin and eosin staining. Read More

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Impact of Pre-, Intra-and Post-Operative Parameters on In-Hospital Mortality in Patients Undergoing Emergency Coronary Artery Bypass Grafting: A Scarce Single-Center Experience in Resource-Scare Setting.

Vasc Health Risk Manag 2021 17;17:211-226. Epub 2021 May 17.

Hanoi Medical University, Hanoi, 100000, Vietnam.

Background: In-hospital mortality after emergency coronary artery bypass grafting (CABG) remains an important issue that has needed considerable attention in recent years as the mortality rate is still high and prevention factors are not yet optimal. Our study presents the first largest cohort of emergency CABG from one large institution in Vietnam with the primary aim of comparing a large variety of pre-, intra-and post-operative parameters between in-hospital mortality patients and in-hospital survival patients and investigate risk factors of in-hospital mortality in patients undergoing emergency CABG.

Methods: We conducted a retrospective evaluation of prospectively collected data in patients undergoing emergency CABG at the Hanoi Heart Hospital (Hanoi, Vietnam) from January 1, 2017, to December 31, 2019. Read More

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