172,203 results match your criteria Arteriosclerosis Thrombosis And Vascular Biology[Journal]


Femoral Artery Sclerosis Evaluation by Tissue Doppler in Patients with Hypertension.

Med Sci Monit 2019 Apr 20;25:2917-2922. Epub 2019 Apr 20.

Department of Ultrasonography, Tianjin Union Medical Center (Tianjin People's Hospital), Tianjin, China (mainland).

BACKGROUND The aim of this study was to evaluate the early femoral sclerosis in hypertensive patients by using tissue Doppler imaging (TDI). MATERIAL AND METHODS One hundred patients with hypertension were recruited and divided into group A (femoral artery intima-media thicknesses (IMT) ≥1.0 mm) and group B (femoral artery IMT <1. Read More

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https://www.medscimonit.com/abstract/index/idArt/913271
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http://dx.doi.org/10.12659/MSM.913271DOI Listing
April 2019
1 Read

4--Carboxymethylascochlorin Inhibits Expression Levels of on Inflammation-Related Cytokines and Matrix Metalloproteinase-9 Through NF-κB/MAPK/TLR4 Signaling Pathway in LPS-Activated RAW264.7 Cells.

Front Pharmacol 2019 27;10:304. Epub 2019 Mar 27.

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea.

Toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) are known to play important roles in inflammatory diseases such as arteriosclerosis and plaque instability. The purpose of this study was to perform the effect of 4--carboxymethylascochlorin (AS-6) on MMP-9 expression in lipopolysaccharide (LPS)-induced murine macrophages and signaling pathway involved in its anti-inflammatory effect. Effect of AS-6 on MAPK/NF-κB/TLR4 signaling pathway in LPS-activated murine macrophages was examined using ELISA, Western blotting, reverse transcription polymerase chain reaction (RT-PCR) and fluorescence immunoassay. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2019.00304
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http://dx.doi.org/10.3389/fphar.2019.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445864PMC
March 2019
1 Read

Cardiovascular Disease: Lower Extremity Peripheral Artery Disease.

FP Essent 2019 Apr;479:11-15

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Lower extremity peripheral artery disease (PAD) refers to atherosclerotic disease that involves the iliac, femoral, or more distal arteries of the lower extremities. This condition affects 8 to 12 million Americans. Risk factors include advanced age, hypertension, dyslipidemia, diabetes, and cigarette smoking. Read More

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April 2019
2 Reads

Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages.

Cytometry A 2019 Apr 17. Epub 2019 Apr 17.

Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, 93053 Regensburg, Germany.

Ezetimibe (EZE) and glucuronidated EZE (EZE-Glu) differentially target Niemann-Pick C1-like 1 (NPC1L1) and CD13 (aminopeptidase-N) to inhibit intestinal cholesterol absorption and cholesterol processing in other cells, although the precise molecular mechanisms are not fully elucidated. Cellular effects of EZE, EZE-Glu, and the low-absorbable EZE-analogue S6130 were investigated on human monocyte-derived macrophages upon loading with atherogenic lipoproteins. EZE and S6130, but not EZE-Glu disturbed the colocalization of CD13 and its coreceptor CD64 (Fcγ receptor I) in membrane microdomains, and decreased the presence of both receptors in detergent-resistant membrane fractions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cyto.a.23772
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http://dx.doi.org/10.1002/cyto.a.23772DOI Listing
April 2019
1 Read

Association between neutrophil-lymphocyte ratio and arterial stiffness in patients with acute coronary syndrome.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

the Second Xiangya Hospital of Central South University, Changsha, China.

The aim of this study was to assess the association between neutrophil-lymphocyte ratio (NLR) and arterial stiffness and provide a predictive index for diagnosing atherosclerosis in patients with acute coronary syndrome. We enrolled patients with acute coronary syndrome who were confirmed by coronary angiography. Data were collected by questionnaire and blood indexes. Read More

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http://dx.doi.org/10.1042/BSR20190015DOI Listing
April 2019
1 Read

Prevalence of extracranial carotid atherosclerosis in the patients with coronary artery disease in a tertiary hospital in Malaysia.

Medicine (Baltimore) 2019 Apr;98(15):e15082

Division of Neurology, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

There is limited information regarding the prevalence of extracranial carotid atherosclerosis in the patients with coronary artery disease (CAD) undergoing coronary artery bypass graft (CABG) surgery in South East Asia. The primary objective was to assess the prevalence of extracranial carotid stenosis, raised carotid intima media thickness (CIMT), and plaques in the patients with CAD undergoing elective CABG. The secondary objective was to evaluate the risk factors for extracranial carotid atherosclerosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000015082DOI Listing
April 2019
2 Reads

Standards for global cardiovascular risk management arteriosclerosis.

Clin Investig Arterioscler 2019 Apr 10. Epub 2019 Apr 10.

Unidad de Lípidos, Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, España.

One of the main goals of the Spanish Society of Arteriosclerosis is to contribute to a wider and greater knowledge of vascular disease, its prevention and treatment. Cardiovascular diseases are the leading cause of death in our country and also lead to a high degree of disability and health expenditure. Arteriosclerosis is a multifactorial disease, this is why its prevention requires a global approach that takes into account the different risk factors with which it is associated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02149168193004
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http://dx.doi.org/10.1016/j.arteri.2019.03.004DOI Listing
April 2019
2 Reads

Primary care management of chest pain after coronary artery bypass surgery.

BMJ 2019 Apr 12;365:l1303. Epub 2019 Apr 12.

Waikato Cardiothoracic Unit, Waikato Hospital, Hamilton, New Zealand

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http://dx.doi.org/10.1136/bmj.l1303DOI Listing

Effects of High-Intensity Interval Training on Microvascular Glycocalyx and Associated microRNAs.

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Molecular Genetics of Cardiovascular Research, Leibniz-Institute for Arteriosclerosis Research.

High-intensity interval training (HIIT) has been proposed to exert vasculoprotective effects. This study aimed to evaluate if HIIT affects the microvasculature including the endothelial glycocalyx barrier and to identify associated microRNAs (miRNAs). Fifty healthy participants (23. Read More

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http://dx.doi.org/10.1152/ajpheart.00751.2018DOI Listing
April 2019
1 Read

Evaluation of the atherosclerotic burden in hypertensive patients with prediabetes.

Clin Investig Arterioscler 2019 Apr 7. Epub 2019 Apr 7.

Centro de Investigaciones Médico-Sanitarias, Universidad de Málaga, Málaga, España.

Aim: To assess the atherosclerotic burden in hypertensive patients with prediabetes without cardiovascular disease.

Patients And Methods: We included patients with hypertension and prediabetes (fasting blood glucose: 100-125mg/dL and/or glycohemoglobin A1c: 5.7-6. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02149168193001
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http://dx.doi.org/10.1016/j.arteri.2019.01.003DOI Listing
April 2019
1 Read

Maraviroc Intensification Modulates Atherosclerotic Progression in HIV-Suppressed Patients at High Cardiovascular Risk. A Randomized, Crossover Pilot Study.

Open Forum Infect Dis 2019 Apr 7;6(4):ofz112. Epub 2019 Mar 7.

Unit of Infectious Diseases, University of Perugia, Perugia, Italy.

Background: Experimental CCR5 antagonism with maraviroc in atherosclerosis-prone mice and preliminary data in humans suggest an anti-atherosclerotic effect of the drug. We assessed the impact of maraviroc treatment in persons living with HIV on subclinical indicators of atherosclerosis.

Methods: Persons living with HIV on effective antiretroviral therapy (ART) including only protease inhibitors were recruited if they had a Framingham risk score >20% and brachial flow-mediated dilation (bFMD) <4%, as indices of high cardiovascular risk. Read More

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http://dx.doi.org/10.1093/ofid/ofz112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446135PMC

Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

Autops Case Rep 2019 Apr-Jun;9(2):e2018070. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Hospital Universitário, Internal Medicine Division. São Paulo, SP, Brazil.

Esophageal infection by spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433139PMC
March 2019
3 Reads

Transplant arteriosclerosis in humanized mice reflects chronic lung allograft dysfunction and is controlled by regulatory T cells.

J Thorac Cardiovasc Surg 2019 Feb 28. Epub 2019 Feb 28.

Division of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany; German Centre for Lung Research BREATH site, Hannover Medical School, Hannover, Germany. Electronic address:

Objective: Chronic lung allograft dysfunction (CLAD) is a severe complication of lung transplantation limiting long-term survival. We studied correlations between CLAD after clinical lung transplantation and leukocyte-mediated development of transplant arteriosclerosis (TA) in a humanized mouse model. The pericardiophrenic artery was procured from surplus tissue of donor lungs (n = 22) transplanted in our clinical program and was implanted into the abdominal aorta of immune-deficient mice. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.134DOI Listing
February 2019
1 Read

Characteristics of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) from the ARIAM-SEMICYUC registry: development of a score for predicting MINOCA.

Vasc Health Risk Manag 2019 13;15:57-67. Epub 2019 Mar 13.

Critical Care Department, Hospital Universitario del Tajo, CP 28300, Aranjuez, Spain,

Background: Acute myocardial infarction (AMI) with no evidence of relevant stenosis of the coronary artery, known as myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA), has a prevalence of up to 14%. The various causes of MINOCA lead to damage of the myocardium, and there are marked differences in diagnoses, prognoses, and treatments. Although the number of patients affected is considerable owing to the high prevalence of acute coronary syndrome (ACS), the causes of MINOCA have received little attention with the result that some patients may not receive appropriate treatment. Read More

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http://dx.doi.org/10.2147/VHRM.S185082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422404PMC
April 2019
3 Reads

Increased inducible nitric oxide synthase (iNOS) expression in human myocardial infarction.

Int J Legal Med 2019 Mar 29. Epub 2019 Mar 29.

Institute of Legal Medicine, University Hospital of Frankfurt, Goethe University Frankfurt/Main, Kennedyallee 104, 60596, Frankfurt am Main, Germany.

Increased inducible nitric oxide synthase (iNOS) expression has been reported in heart failure, cardiomyopathies, and arteriosclerosis. iNOS is expressed in the heart upon inflammatory stimuli and produces excessive amounts of nitric oxide (NO). The overproduction of NO is cytotoxic and involved in cardiovascular diseases. Read More

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http://dx.doi.org/10.1007/s00414-019-02051-yDOI Listing

Comparison of arterial stiffness indices measured by pulse wave velocity and pulse wave analysis.

Blood Press 2019 Mar 29:1-8. Epub 2019 Mar 29.

a Department of Cardiology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.

Objective: Arterial stiffness indices measured by pulse wave velocity and pulse wave analysis have been widely studied in different populations. Only a few small studies have been reported regarding these two measurement methods. Therefore, the aim of our study was to compare the arterial stiffness indices measured by pulse wave velocity and pulse wave analysis in a randomly selected Chinese population. Read More

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http://dx.doi.org/10.1080/08037051.2019.1598254DOI Listing

[Immunization as Treatment for arteriosclerosis-a realistic vision?]

Authors:
H Winkels S Baldus

Herz 2019 Apr;44(2):93-95

Herzzentrum, Abt. f. Kardiologie, Universität Köln, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00059-019-4793-8DOI Listing

Mönckeberg's arteriosclerosis: a possible reason for non-use of radial conduit.

Asian Cardiovasc Thorac Ann 2019 Mar 28:218492319841977. Epub 2019 Mar 28.

1 Department of Cardiology, Gaziosmanpasa Hospital, Faculty of Medicine, Istanbul Yeni Yuzyil University, Istanbul, Turkey.

We report the case of a 73-year-old man with diffuse calcification in both upper and lower limb arteries. This condition, termed Mönckeberg's arteriosclerosis, was accompanied by three-vessel disease needing coronary artery bypass grafting. The diagnosis of arteriosclerosis was further verified by histopathology. Read More

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http://dx.doi.org/10.1177/0218492319841977DOI Listing

The Scavenger Receptor CD68 Regulates Platelet Mediated Oxidized Low-Density Lipoprotein (oxLDL) Deposition in Atherosclerotic Vessels at an Early Stage of Atherosclerosis in LDLR/ApoBec Mice.

Cell Physiol Biochem 2019 ;52(4):681-695

AdvanceCOR, Martinsried, Germany,

Background/aims: Oxidative modifications of low-density lipoprotein (ox-LDL) play a key role in initial steps of atheroprogression possibly via specific scavenger receptors on inflammatory and endothelial cells. Amongst others, CD68 might play a crucial role in this leading to fatty streak formation.

Methods: Different CD68-Fc fusion proteins were cloned, expressed and tested in vitro for their oxLDL binding properties as a decoy for endogenous oxLDL. Read More

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http://dx.doi.org/10.33594/000000048DOI Listing
April 2019
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The epidemiology of coronary artery bypass surgery in a community hospital: A comparison between 2 periods.

Medicine (Baltimore) 2019 Mar;98(13):e15059

Division of Cardiac Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA/Cape Cod Hospital, Hyannis, MA.

During the last decades, the increased number of percutaneous interventions procedures causes a significant change in the profile of patients referred to coronary artery bypass grafting (CABG). We aimed to study changes in patients' characteristics and procedural outcomes of patients referred to CABG in a community hospital during the first 15 years of the millennium.A historical cohort study of all patients who underwent CABG in Cape Cod Hospital was performed. Read More

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http://dx.doi.org/10.1097/MD.0000000000015059DOI Listing
March 2019
1 Read

Comparison between paclitaxel-coated balloon and standard uncoated balloon in the treatment of femoropopliteal long lesions in diabetics.

Medicine (Baltimore) 2019 Mar;98(13):e14840

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Atherosclerotic diseases may include femoropopliteal artery stenosis or occlusion. Percutaneous transluminal angioplasty (PTA) is an effective and minimally invasive treatment strategy for atherosclerotic femoropopliteal artery stenosis/occlusion disease. Balloon angioplasty is a widely used technique in the management of occlusive disease in almost all arterial segments. Read More

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http://dx.doi.org/10.1097/MD.0000000000014840DOI Listing
March 2019
10 Reads

The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease.

Oxid Med Cell Longev 2019 24;2019:3231424. Epub 2019 Feb 24.

Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. Read More

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https://www.hindawi.com/journals/omcl/2019/3231424/
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http://dx.doi.org/10.1155/2019/3231424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409025PMC
April 2019
5 Reads

Cardiac Pathology and Genomics of Sudden Death in Racehorses From New York and Maryland Racetracks.

Vet Pathol 2019 Mar 27:300985819829529. Epub 2019 Mar 27.

1 Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Postmortem evaluation of racehorses has focused primarily on musculoskeletal injuries; however, horses also die suddenly on the track (sudden death [SD]). Although cardiac conditions are frequently suspected as a cause of death, SD racehorses are often autopsy negative; however, previous studies have been limited due to inconsistent or insufficient cardiac sampling and lack of controls. SD in New York (NY) and Maryland (MD) racehorses was evaluated in an observational case vs control study comparing clinical information, postmortem evaluation including cardiac dissection, and cardiac conduction system histopathology. Read More

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http://dx.doi.org/10.1177/0300985819829529DOI Listing
March 2019
1 Read

The relationship among angiotensinogen genes polymorphisms and hs-CRP and coronary artery disease.

J Clin Lab Anal 2019 Mar 26:e22881. Epub 2019 Mar 26.

Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, Taizhou, China.

Objective: To assess the association of gene polymorphisms of angiotensinogen (AGT), the key factor in rennin-angiotensin-aldosterone system (RAAS), with high-sensitivity C-reactive protein (hs-CRP) and coronary artery disease (CAD).

Methods: The current study recruited the patients who were hospitalized and assessed by coronary angiography for suspected CAD. The patients with documented CAD served as CAD group (n = 492) while the patients without documented CAD (n = 87) served as control group. Read More

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http://dx.doi.org/10.1002/jcla.22881DOI Listing
March 2019
1 Read

Effects of Cornelian Cherry on Atherosclerosis and Its Risk Factors.

Oxid Med Cell Longev 2019 17;2019:2515270. Epub 2019 Feb 17.

Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.

Functional food represents an important alternative management of atherosclerosis, its risk factors, and clinical complications. Atherosclerosis is characterized by microinflammation, formation of atheromatous lipoprotein-rich plaques, and protrombogenic status. Cornelian cherry (. Read More

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http://dx.doi.org/10.1155/2019/2515270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397968PMC
April 2019
1 Read

A review of gene- and cell-based therapies for familial hypercholesterolemia.

Pharmacol Res 2019 May 22;143:119-132. Epub 2019 Mar 22.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. A rare form of autosomal recessive FH has been also described due to LDLr adaptor protein 1 (LDLRAP1) gene mutations. FH is characterized by very high levels of plasma LDL cholesterol associated with the high incidence of premature atherosclerotic cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.016DOI Listing
May 2019
1 Read

SEA/SEMERGEN consensus document 2019: Dietary recommendations in the prevention of cardiovascular disease.

Clin Investig Arterioscler 2019 Mar 22. Epub 2019 Mar 22.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, España; Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universidad de Barcelona, Barcelona, España; Unidad de Lípidos, Servicio de Endocrinología y Nutrición, Hospital Clínic, Barcelona, España; Grupo de Trabajo Nutrición y Estilo de Vida, Sociedad Española de Arteriosclerosis (SEA).

The current paradigm in the nutrition sciences states that the basic nutritional unit is not the nutrients, but the foods that contain them (oils, nuts, dairy products, eggs, red or processed meats, etc.). These act as a food matrix in which the different nutrients synergistically or antagonistically modulate their effects on the various metabolic pathways determining health and disease. Read More

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http://dx.doi.org/10.1016/j.arteri.2019.02.004DOI Listing

Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study.

Int J Food Sci Nutr 2019 Mar 25:1-7. Epub 2019 Mar 25.

a Research & Development , Kao Corporation , Tokyo , Japan.

The effect of chlorogenic acid-enriched green coffee bean extract (cGCE) intake on arterial stiffness was investigated using the cardio-ankle vascular index (CAVI) as a novel surrogate marker for predicting arteriosclerosis. A placebo-controlled double-blind pilot study was conducted with 16 healthy Japanese men. Subjects were divided into two groups and consumed beverages containing either cGCE or placebo daily for 2 weeks. Read More

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http://dx.doi.org/10.1080/09637486.2019.1585763DOI Listing

Glycated serum proteins: High in pancreatic cancer and low in preeclampsia.

Prog Mol Biol Transl Sci 2019 6;162:321-333. Epub 2019 Mar 6.

Department of Internal Medicine, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic patients. However, a systematic comparison of the GSP levels in different types of human diseases has not been reported. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2019.01.007DOI Listing
March 2019
2 Reads

Effect of chronic kidney disease in ischemic cardiomyopathy: Long-term follow-up - REVISION-DM2 trial.

Medicine (Baltimore) 2019 Mar;98(12):e14692

Division of Clinical Cardiology, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil.

A strong association exists between chronic kidney disease (CKD) and coronary artery disease (CAD). The role of CKD in the long-term prognosis of CAD patients with versus those without CKD is unknown. This study investigated whether CKD affects ventricular function. Read More

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http://dx.doi.org/10.1097/MD.0000000000014692DOI Listing
March 2019
1 Read

Tissue Doppler Imaging Predicts Outcomes in Hemodialysis Patients with Preserved Left Ventricular Function.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, ROC.

Background: Cardiovascular disease is a major cause of mortality in patients with end-stage renal disease (ESRD). In addition to arteriosclerosis (arterial stiffness) and atherosclerosis, left ventricular hypertrophy and left ventricular systolic dysfunction are the major cardiac determinants of cardiovascular mortality in hemodialysis patients. Although left ventricular diastolic dysfunction is common in patients with ESRD, its prognostic value is yet to be established. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000078DOI Listing

The overexpression of lncRNA H19 as a diagnostic marker for coronary artery disease.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):110-117

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Jiefang Road 238, Wuchang, 430060, Wuhan, PR China.

Objective: Our study aimed to investigate the diagnostic value of lncRNA H19 for coronary artery disease (CAD) and to explore its possible mechanisms.

Methods: A total of 30 CAD patients and 30 healthy individuals, as well as patients with different cardiovascular diseases, were included in this study. Blood was drawn from each participant to prepare serum samples, and the expression of lncRNA H19 was detected using qRT-PCR. Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.110DOI Listing
February 2019
1 Read

Memantine for dementia.

Cochrane Database Syst Rev 2019 03 20;3:CD003154. Epub 2019 Mar 20.

Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 4, Main Hospital, Room 4401C, Oxford, Oxfordshire, UK, OX3 9DU.

Background: Memantine is a moderate affinity uncompetitive antagonist of glutamate NMDA receptors. It is licensed for use in moderate and severe Alzheimer's disease (AD); in the USA, it is also widely used off-label for mild AD.

Objectives: To determine efficacy and safety of memantine for people with dementia. Read More

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http://dx.doi.org/10.1002/14651858.CD003154.pub6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425228PMC
March 2019
1 Read

Significance of the Pathologic Findings in Implantation Biopsies for Kidney Allografts Survival.

Int J Organ Transplant Med 2019 1;10(1):15-29. Epub 2019 Feb 1.

Department of Transplantology, Endocrine Surgery and Cardiovascular Surgery, State Institution.

Background: There is no consistent association between individual histological lesions and composite scores in donor kidney biopsy and transplant outcomes.

Objective: To evaluate which acute or chronic individual histological lesions and composite scores in donor kidney were associated with graft survival in the recipient.

Methods: We investigated the association of individual histological lesions and 8 composite scoring systems in implantation biopsies of cadaveric (n=101) and living (n=29) kidneys with 5-year death-censored graft survival. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416998PMC
February 2019

Comparison of serum levels of Cystatin-C and traditional renal biomarkers for the early detection of pre-hypertensive nephropathy.

J Pak Med Assoc 2019 Mar;69(3):313-319

Rawal Institute of Health Sciences, Islamabad.

Objective: To compare serum Cystatin-C and serum creatinine levels along with estimated glomerular filtration rate of apparently healthy people of South Asian descent with pre-hypertension to determine which is better in detecting reversible renal dysfunction.

Methods: :The comparative cross-sectional study was conducted at the Army Medical College, Rawalpindi, Pakistan, in 2013-14, and comprised apparently normal healthy male and female volunteers. The subjects were divided into normotensive group 1 and pre-hypertensive group 2. Read More

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March 2019
2 Reads

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.

Nat Commun 2019 03 19;10(1):1252. Epub 2019 Mar 19.

Department of Medical and Clinical Genetics, University of Helsinki, FI-00014, Helsinki, Finland.

Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline TET2 mutation in a lymphoma family. We observe neither unusual predisposition to atherosclerosis nor abnormal pro-inflammatory cytokine or chemokine expression. Read More

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http://dx.doi.org/10.1038/s41467-019-09198-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424975PMC
March 2019
8 Reads

[Correlation of lipoprotein(a) with clinical stability and severity of coronary artery lesions in patients with coronary artery disease].

Nan Fang Yi Ke Da Xue Xue Bao 2019 02;39(2):235-240

Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To analyze the correlation of lipoprotein(a) [Lp(a)] with the clinical stability and severity of coronary artery stenosis in patients with coronary artery disease (CAD).

Methods: A total of 531 patients undergoing coronary angiography in Nanfang Hospital between January, 2013 and December, 2016 were enrolled in this study. At the cutoff Lp(a) concentration of 300 mg/L, the patients were divided into high Lp(a) group (=191) and low Lp(a) group (=340). Read More

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http://dx.doi.org/10.12122/j.issn.1673-4254.2019.02.17DOI Listing
February 2019
3 Reads

Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial.

Nutrition 2019 Jun 11;62:135-139. Epub 2019 Jan 11.

Human Performance Laboratory, Ball State University, Muncie, Indiana 47306, USA. Electronic address:

Objectives: This study aimed to determine whether an enhanced bioavailable curcumin formulation, CurQfen®, would improve circulating cardiovascular disease-related blood biomarkers and arterial function in young (age 18-35 y), obese (body mass index ≥ 30.0 kg/m) men.

Methods: This double-blinded, placebo-controlled trial evaluated 22 men. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08999007183078
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http://dx.doi.org/10.1016/j.nut.2019.01.002DOI Listing
June 2019
4 Reads

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery.

N Engl J Med 2019 03 19;380(13):1214-1225. Epub 2019 Mar 19.

From the Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute (G.L., F.M., R.L., N.D.T., M.C., M.P., A.B., A.M.S., M.G.C., A.Z.), and Vita-Salute San Raffaele University (G.L., A.Z.), Milan, Istituto di Anestesia e Rianimazione, Azienda Ospedaliera di Padova, Padua (C.C.), Anesthesia and Intensive Care Department, University Campus Bio-Medico of Rome (F.E.A.), and Anestesia e Rianimazione, Dipartimento Cardiovascolare, Azienda Ospedaliera San Camillo Forlanini (L.S.), Rome, the Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, University Hospital Policlinico S. Orsola, Bologna (M.B.), Dipartimento di Scienze Mediche e Chirurgiche, Università Magna Graecia di Catanzaro, Catanzaro (P.N.), Anestesia e Terapia Intensiva Cardiochirurgica, Istituto Clinico Humanitas, Rozzano (G.C.), the Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, and the Department of Surgical Sciences, University of Turin, Turin (L.B.), and the Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine (T.B.) - all in Italy; the Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk (V.V. Lomivorotov, V.A.S., D.N.P.), the Departments of Anesthesiology and Intensive Care (V.V.P.) and Cardiac Surgery (D.G.T.), Federal Center for Cardiovascular Surgery Astrakhan, Astrakhan, the Department of Anesthesia and Intensive Care, First Moscow State Medical University (V.V.P., V.V. Likhvantsev), and the Department of Intensive Care, Moscow Regional Clinical and Research Institute (V.V. Likhvantsev), Moscow, the Department of Anesthesia and Intensive Care, Ural Institute of Cardiology, Ekaterinburg (A.L.), the Laboratory for Anesthesiology and Intensive Care, Almazov National Medical Research Center, Saint Petersburg (A.E.B.), and the Intensive Care Unit, Scientific Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (E.V.G.) - all in Russia; the Anesthesia Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (C.N.N.), the Department of Cardiopneumology, Instituto do Coração, Universidade de São Paulo, and the Intensive Care Unit, Hospital SirioLibanes (L.A.H.), and the Cardiac Surgery Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (R.A.), São Paulo, Brazil; the Department of Cardiovascular Anesthesiology and Intensive Care Medicine, and the Clinical Department of Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava, Zagreb (N.B.), and the Department of Biomedical Sciences, University North, Varaždin (N.B.) - both in Croatia; the Department of Anesthesia and Intensive Care, Cardiovascular Institute Dedinje (G.G., M.J.), and the School of Medicine, University of Belgrade (M.J.), Belgrade, Serbia; the Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi (C.L.), and the Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing (J.M.) - both in China; the Cardiothoracic Intensive Care Unit and Anesthesia Department, Mohammed Bin Khalifa Cardiac Center, Riffa, Bahrain (N.A.R.B.); the Department of Anesthesiology, Hospital de Santa Maria, Lisbon, Portugal (F.S.S.); the Department of Anesthesia, King Abdullah Medical City-Holy Capital, Makkah (A.M.G.A.F.), and the Anesthesiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam (M.R.E.-T.) - both in Saudi Arabia; Anesthesia and Intensive Care, Acibadem City Clinic-Cardiac Surgery Center, Burgas, Bulgaria (N.S.U.); the Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital (J.K.), and the Cardiothoracic Anesthesiology and Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine (H.R.), Prague, Czech Republic; the Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia (C.Y.W.); the Anesthesia and Surgical Intensive Care Department, Faculty of Medicine, Zagazig University Hospitals, Zagazig (A.M.E.), and the Department of Anesthesia and Surgical Intensive Care, Mansoura University, Mansoura (M.A.H.) - both in Egypt; and the School of Medicine, University of Melbourne, Melbourne, VIC, Australia (R.B.).

Background: Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG).

Methods: We conducted a pragmatic, multicenter, single-blind, controlled trial at 36 centers in 13 countries. Patients scheduled to undergo elective CABG were randomly assigned to an intraoperative anesthetic regimen that included a volatile anesthetic (desflurane, isoflurane, or sevoflurane) or to total intravenous anesthesia. Read More

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http://dx.doi.org/10.1056/NEJMoa1816476DOI Listing
March 2019
1 Read
55.873 Impact Factor

Nonalcoholic fatty liver disease represents a greater metabolic burden in patients with atherosclerosis: A cross-sectional study.

Medicine (Baltimore) 2019 Mar;98(11):e14896

Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan.

How nonalcoholic fatty liver disease (NAFLD) is linked to atherosclerosis is still disputed. This study aimed to explore the association between NAFLD and atherosclerosis among adults in Shandong province, China.A total of 6849 individuals were enrolled in the final analyses for a community-based study. Read More

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http://dx.doi.org/10.1097/MD.0000000000014896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426626PMC

Thalidomide ameliorate graft chronic rejection in an allogenic kidney transplant model.

Int Immunopharmacol 2019 Mar 12;71:32-39. Epub 2019 Mar 12.

Department of Urology, Qianfoshan Hospital Affiliated to Shandong University, China. Electronic address:

Chronic T cell mediated rejection (TCMR), which is characterized by infiltration of the interstitium by T cells and macrophages, still remains a major barrier to the long-term survival of kidney transplantation. Our recent report indicated that thalidomide can attenuate graft arteriosclerosis in an aortic transplant model. In this study, we investigated the effect of thalidomide on chronic TCMR in a rat model of kidney transplantation. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.12.035DOI Listing
March 2019
9 Reads

Biochemical diagnosis of vascular cognitive impairment associated with subcortical small vessels disease.

Hell J Nucl Med 2019 Jan-Apr;22 Suppl:187-193

Cognitive and Movement Disorders Unit and Unit of Neurochemistry and Biological Markers, 1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Subcortical small-vessel disease (SSVD) is a disorder that has been fully described in clinical, neuropathological and imaging aspects. It is considered as the most prevalent ischemic CNS disorder and has been associated to arterial hypertension, diabetes mellitus, dyslipidemia and obstructive sleep apnea. The hallmark of SSVD is the ischemic white matter lesions which can be presented as lacunar infracts and global brain hypoperfusion in a common and homogeneous subtype of vascular cognitive impairment (VCI) which is often unrecognized. Read More

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January 2019
1 Read

Latest Updates on Lipid Management.

High Blood Press Cardiovasc Prev 2019 Apr 15;26(2):85-100. Epub 2019 Mar 15.

Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Tallaght Hospital, Tallaght, Dublin 24, Ireland.

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide. Despite the clinical long-term and near-term benefits of lowering cholesterol in, respectively, primary and secondary prevention of ASCVD, cholesterol levels remain under-treated, with many patients not achieving their recommended targets. The present article will review the latest updates on lipid management with emphases on the different classes of cholesterol-lowering agents and their clinical uses. Read More

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http://link.springer.com/10.1007/s40292-019-00306-8
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http://dx.doi.org/10.1007/s40292-019-00306-8DOI Listing
April 2019
8 Reads

National and subnational estimation of the prevalence of peripheral artery disease (PAD) in China: a systematic review and meta-analysis.

J Glob Health 2019 Jun;9(1):010601

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.

Background: Peripheral artery disease (PAD), the third leading cause of atherosclerotic vascular morbidity, affects approximately 202 million people worldwide, among whom more than two-thirds reside in low- and middle-income countries (LMIC). For China, the largest developing country, little is known about the epidemiology of PAD. We aimed to estimate the prevalence of PAD and the number of affected people in China, establish the main risk factors for PAD and assess the number of people with PAD at the sub-national level. Read More

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http://dx.doi.org/10.7189/jogh.09.010601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377796PMC
June 2019
2 Reads

Risk Factors Associated With Reintervention After Thoracic Endovascular Aortic Repair for Descending Aortic Pathologies.

Vasc Endovascular Surg 2019 Apr 13;53(3):181-188. Epub 2018 Dec 13.

1 Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background:: Thoracic endovascular aortic repair (TEVAR) is associated with several short-term benefits, including reduced morbidity and mortality; however, the long-term durability of TEVAR and the need for secondary aortic reintervention remain unclear. We aimed to determine the adverse outcomes, including aortic reintervention, after TEVAR for thoracic aortic aneurysms and dissection.

Methods:: Between October 2009 and July 2016, 130 patients underwent TEVAR at Kyungpook National University Hospital. Read More

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http://dx.doi.org/10.1177/1538574418814989DOI Listing
April 2019
6 Reads

Applying the China-PAR Risk Algorithm to Assess 10-year Atherosclerotic Cardiovascular Disease Risk in Populations Receiving Routine Physical Examinations in Eastern China.

Biomed Environ Sci 2019 Feb;32(2):87-95

Obesity and Diabetes Center of Naval Medical University, Shanghai 200433, China.

Objective: To assess the 10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk score among adults in eastern China using the China-PAR equation which formulated primarily for the Chinese population.

Methods: Data from 72,129 individuals from 35-74 years old who received routine physical examinations in eastern China were analyzed in this study. The 10-year risk scores were calculated using the China-PAR equation. Read More

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http://dx.doi.org/10.3967/bes2019.014DOI Listing
February 2019
2 Reads

[Immunity and inflammation in atherosclerosis].

Authors:
D Wolf K Ley

Herz 2019 Apr;44(2):107-120

Division of Inflammation Biology, La Jolla Institute for Immunology, 9420 Athena Cir, 92037, La Jolla, CA, USA.

There is now overwhelming experimental and clinical evidence that arteriosclerosis is a chronic inflammatory disease. Lessons learned from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice models and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb arteriosclerosis. This article summarizes and discusses the pathogenesis of arteriosclerosis with a focus on the role of the adaptive immune system. Read More

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http://dx.doi.org/10.1007/s00059-019-4790-yDOI Listing

Rivaroxaban in Patients with Heart Failure.

N Engl J Med 2019 03;380(10):988

Yonsei University College of Medicine, Seoul, South Korea

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http://dx.doi.org/10.1056/NEJMc1816756DOI Listing

Strong association between the interleukin-8-251A/T polymorphism and coronary artery disease risk.

Medicine (Baltimore) 2019 Mar;98(10):e14715

Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University.

Several reports have suggested a possible association between the interleukin (IL)-8-251A/T single-nucleotide polymorphism (SNP) and the susceptibility to coronary artery disease (CAD). Due to inconclusive results of the studies so far, we conducted a meta-analysis to systematically summarize the studies on the association between this SNP and CAD risk. A systematic literature search identified 9 case-control studies (3752 cases and 4219 controls) on the IL-8-251A/T polymorphism. Read More

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http://dx.doi.org/10.1097/MD.0000000000014715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417535PMC
March 2019
1 Read
5.723 Impact Factor

Inverse regulation of serum osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand levels in patients with leg lesional vascular calcification: An observational study.

Medicine (Baltimore) 2019 Mar;98(10):e14489

Vascular and endovascular division, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea.

We hypothesized that circulating osteoprotegerin (OPG) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels could be associated with vascular calcification, which is predominant in diabetes.The study included 71 Korean participants (36 with diabetes and 35 without diabetes), who were sub-grouped according to the results of the ankle-brachial index (ABI) and/or X-ray computed tomography scan (CT scan). Serum OPG and TRAIL levels were assayed using the respective enzyme-linked immunosorbent assay kits. Read More

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http://dx.doi.org/10.1097/MD.0000000000014489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417519PMC
March 2019
1 Read