9,002 results match your criteria Arterioscler. Thromb. Vasc. Biol.[Journal]


Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms.

Arterioscler Thromb Vasc Biol 2019 Apr 4:ATVBAHA118311727. Epub 2019 Apr 4.

From the Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.C., J.C., J.R., F.L., A.L.T., A.F., J.H., M.R.B., H.F.J., Z.M.).

Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the behavior of VSMCs during the formation of dissecting AA is poorly understood. Approach and Results- We used multicolor lineage tracing of VSMCs to track their fate after injury in murine models of Ang II (angiotensin II)-induced dissecting AA. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311727DOI Listing
April 2019
2 Reads

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Apr 4:ATVBAHA118312038. Epub 2019 Apr 4.

From the Department of Anesthesiology, University of Illinois at Chicago (S.D.S.O., M.C., R.D.M.).

Objective- To determine whether pulmonary arterial hypertension is associated with endothelial cell (EC)-Cav-1 (caveolin-1) depletion, EC-derived extracellular vesicle cross talk with macrophages, and proliferation of Cav-1 depleted ECs via TGF-β (transforming growth factor-β) signaling. Approach and Results- Pulmonary vascular disease was induced in Sprague-Dawley rats by exposure to a single injection of VEGFRII (vascular endothelial growth factor receptor II) antagonist SU5416 (Su) followed by hypoxia (Hx) plus normoxia (4 weeks each-HxSu model) and in WT (wild type; Tie2.Cre ;Cav1 ) and EC- Cav1 (Tie2. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312038DOI Listing
April 2019
1 Read

Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation.

Arterioscler Thromb Vasc Biol 2019 Apr 4:ATVBAHA118312263. Epub 2019 Apr 4.

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, China (T.Z., J.L., X.C., J.P., Y.K., Y.W., Z.Y., L.Z., Z.L., Y.Z.).

Objective- Transcription factor GATA (GATA zinc finger transcription factor family)-6 is highly expressed in vessels and rapidly downregulated in balloon-injured carotid arteries and viral delivery of GATA-6 to the vessels limited the neointimal formation, however, little is known about its cell-specific regulation of in vivo vascular smooth muscle cell (VSMC) phenotypic state contributing to neointimal formation. This study aims to determine the role of vascular cell-specific GATA-6 in ligation- or injury-induced neointimal hyperplasia in vivo. Approach and Results- Endothelial cell and VSMC-specific GATA-6 deletion mice are generated, and the results indicate that endothelial cell-specific GATA-6 deletion mice exhibit significant decrease of VSMC proliferation and attenuation of neointimal formation on artery ligation and injury compared with the wild-type littermate control mice. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312263DOI Listing
April 2019
3 Reads
6.000 Impact Factor

Circulating TNFSF14 (Tumor Necrosis Factor Superfamily 14) Predicts Clinical Outcome in Patients With Stable Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2019 Apr 4:ATVBAHA118312166. Epub 2019 Apr 4.

From the Divison of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taiwan (R.-H.C., P.-H.H., H.-B.L., S.-J.L., J.-W.C.).

Objective- Basic research indicates that TNFSF14 (tumor necrosis factor superfamily 14) may be involved in the pathogenesis of atherosclerosis. Given the requirements of new biomarkers for risk classification in coronary artery disease (CAD), we conducted a longitudinal analysis to investigate if TNFSF14 levels are associated with the risk of cardiovascular events among patients with stable CAD. Approach and Results- In total, 894 patients with CAD were enrolled in a multicenter prospective study. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312166DOI Listing

Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing.

Arterioscler Thromb Vasc Biol 2019 Apr 4:ATVBAHA119312399. Epub 2019 Apr 4.

From the School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre, United Kingdom (W.G., Z.N., J.D., Y.H., Q.X.).

Objective- Vascular adventitia encompasses progenitors and is getting recognized as the major site of inflammation in early stage of atherosclerosis. However, the cellular atlas of the heterogeneous adventitial cells, the intercellular communication, the cellular response of adventitia to hyperlipidemia, and its contribution to atherosclerosis have been elusive. Approach and Results- Single-cell RNA sequencing was applied to wt (wild type) and ApoE (apolipoprotein E)-deficient aortic adventitia from 12-week-old C57BL/6J mice fed on normal laboratory diet with early stage of atherosclerosis. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312399DOI Listing
April 2019
1 Read

High Plasma sRAGE (Soluble Receptor for Advanced Glycation End Products) Is Associated With Slower Carotid Intima-Media Thickness Progression and Lower Risk for First-Time Coronary Events and Mortality.

Arterioscler Thromb Vasc Biol 2019 Mar 28:ATVBAHA118312319. Epub 2019 Mar 28.

From the Department of Clinical Sciences Malmö, Lund University, Sweden (H.G.L., G.M., P.M.N., J.N., G.E., O.M., M.O.-M., A.S.).

Objective- The RAGE (receptor for advanced glycation end products) and the EMMPRIN (extracellular matrix metalloproteinase inducer) are immune receptors for proinflammatory mediators. These receptors can also be found in a soluble form in the circulation. Soluble RAGE (sRAGE) has shown atheroprotective properties in animal studies, possibly by acting as a decoy receptor for its ligands. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312319DOI Listing

Emerging Magnetic Resonance Imaging Techniques for Atherosclerosis Imaging.

Arterioscler Thromb Vasc Biol 2019 Mar 28:ATVBAHA118311756. Epub 2019 Mar 28.

From the Biomedical Engineering and Physics, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands (R.C.I.W., M.R.R.D., B.F.C., G.J.S.).

Atherosclerosis is a prevalent disease affecting a large portion of the population at one point in their lives. There is an unmet need for noninvasive diagnostics to identify and characterize at-risk plaque phenotypes noninvasively and in vivo, to improve the stratification of patients with cardiovascular disease, and for treatment evaluation. Magnetic resonance imaging is uniquely positioned to address these diagnostic needs. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311756DOI Listing

Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications.

Arterioscler Thromb Vasc Biol 2019 Mar 28:ATVBAHA118312301. Epub 2019 Mar 28.

From the Department of Medicine, University of California, San Diego (M.H., S.L., H.-C.H., Z.C., M.M., H.-Y.H., S.-H.S., Jiao Zhang, W.-T.W., J.K., S.C., J.Y.-J.S.).

Objective- The topographical distribution of atherosclerosis in vasculature underscores the importance of shear stress in regulating endothelium. With a systems approach integrating sequencing data, the current study aims to explore the link between shear stress-regulated master transcription factor and its regulation of endothelial cell (EC) function via epigenetic modifications. Approach and Results- Acetylation of histone 3 lysine 27 (H3K27ac)-chromatin immunoprecipitation followed by high throughput sequencing, an assay for transposase-accessible chromatin-sequencing, and RNA-sequencing were performed to investigate the genome-wide epigenetic regulations in ECs in response to atheroprotective pulsatile shear stress (PS). Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312301DOI Listing
March 2019
1 Read
6.000 Impact Factor

Updates on Approaches for Studying Atherosclerosis.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):e108-e117

From the Saha Cardiovascular Research Center (C.W., A.D., H.S.L.), University of Kentucky, Lexington.

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http://dx.doi.org/10.1161/ATVBAHA.119.312001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438191PMC

Legumain in Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):536-537

From the Departments of Biomedical and Molecular Sciences, Medicine and Surgery, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.119.312430DOI Listing

Ahead of the Curve.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):531-532

From the Department of Radiology, Dalio Institute of Cardiovascular Imaging, NewYork-Presbyterian Hospital/Weill Cornell Medicine; and Department of Cardiovascular Medicine, National Heart Centre Singapore.

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http://dx.doi.org/10.1161/ATVBAHA.119.312433DOI Listing

AB023, A Novel Antibody That Binds Factor XI and Blocks Its Activation by Factor XIIa.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):533-535

From the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.119.312459DOI Listing

Focal Adhesion Kinases in Platelet Function and Thrombosis.

Arterioscler Thromb Vasc Biol 2019 Mar 21:ATVBAHA118311787. Epub 2019 Mar 21.

From the Department of Biology and Biotechnology, University of Pavia, Italy.

The focal adhesion kinase family includes 2 homolog members, FAK and Pyk2 (proline-rich tyrosine kinase 2), primarily known for their roles in nucleated cells as regulators of cytoskeletal dynamics and cell adhesion. FAK and Pyk2 are also expressed in megakaryocytes and platelets and are activated by soluble agonists and on adhesion to the subendothelial matrix. Despite high sequence homology and similar molecular organization, FAK and Pyk2 play different roles in platelet function. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311787DOI Listing

Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome.

Arterioscler Thromb Vasc Biol 2019 Mar 21:ATVBAHA118311987. Epub 2019 Mar 21.

From the Centro E. Grossi Paoletti, Università degli Studi di Milano, Italy (A.O., S.S., M.G., A.S., G.F., L.C.).

Objective- Aim of this study was to evaluate changes in LCAT (lecithin:cholesterol acyltransferase) concentration and activity in patients with an acute coronary syndrome, to investigate if these changes are related to the compromised capacity of HDL (high-density lipoprotein) to promote endothelial nitric oxide (NO) production, and to assess if rhLCAT (recombinant human LCAT) can rescue the defective vasoprotective HDL function. Approach and Results- Thirty ST-segment-elevation myocardial infarction (STEMI) patients were enrolled, and plasma was collected at hospital admission, 48 and 72 hours thereafter, at hospital discharge, and at 30-day follow-up. Plasma LCAT concentration and activity were measured and related to the capacity of HDL to promote NO production in cultured endothelial cells. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311987DOI Listing
March 2019
2 Reads
6.000 Impact Factor

Liquid Biopsy of Extracellular Microvesicles Maps Coronary Calcification and Atherosclerotic Plaque in Asymptomatic Patients With Familial Hypercholesterolemia.

Arterioscler Thromb Vasc Biol 2019 Mar 14:ATVBAHA118312414. Epub 2019 Mar 14.

From the Cardiovascular Science Institute - ICCC; IIB-Sant Pau, Hospital de Sant Pau, Barcelona, Spain (G.C.-B., T.P., J.C., L.B.).

Objective- Heterozygous familial hypercholesterolemia (FH) is the most common genetic disorder associated with premature atherosclerotic cardiovascular disease (CVD). Circulating microvesicles (cMV) are released when cells are activated. We investigated whether cMV could provide information on coronary calcification and atherosclerosis in FH patients. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312414DOI Listing
March 2019
2 Reads

Smoking and Increased White and Red Blood Cells.

Arterioscler Thromb Vasc Biol 2019 Mar 14:ATVBAHA118312338. Epub 2019 Mar 14.

From the Department of Clinical Biochemistry and the Copenhagen General Population Study, Copenhagen University Hospital, Herlev and Gentofte Hospital, Denmark (K.M.P., Y.Ç., S.E.B., B.G.N.).

Objective- Whether tobacco smoking causally affects white and red blood cells and thrombocyte counts is unknown. Using a Mendelian randomization approach, we tested the hypothesis that smoking causes increases in these blood cell indices. Approach and Results- We included 104 607 white Danes aged 20 to 100 years from the Copenhagen General Population Study with information on blood cell indices, smoking habits, and CHRNA3 (alpha 3 nicotinic cholinergic receptor) rs1051730 genotype, where the T allele causes higher tobacco consumption; 41 759 were former smokers and 17 852 current smokers. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312338DOI Listing
March 2019
1 Read

Is Homoarginine a Protective Cardiovascular Risk Factor?

Arterioscler Thromb Vasc Biol 2019 Mar 14:ATVBAHA118312218. Epub 2019 Mar 14.

Division of Angiology, Department of Internal Medicine III, University Center for Vascular Medicine, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Germany (N.J., N.W., R.N.R.).

A series of recent epidemiological studies have implicated the endogenous nonproteinogenic amino acid l-homoarginine as a novel candidate cardiovascular risk factor. The association between homoarginine levels and the risk of adverse cardiovascular outcomes is inverse (ie, high cardiovascular risk is predicted by low rather than high homoarginine levels), which makes it plausible to normalize systemic homoarginine levels via oral supplementation. The emergence of homoarginine as a potentially treatable protective cardiovascular risk factor has generated a wave of hope in the field of cardiovascular prevention. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312218DOI Listing
March 2019
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Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment.

Arterioscler Thromb Vasc Biol 2019 Mar 14:ATVBAHA119312336. Epub 2019 Mar 14.

From the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (K.S., T.O., K.N., M.M., S.K., M.S., H.A., T.S., J.T., Y.S., H.S.).

Objective- Secondary prevention for recurrent myocardial infarction (MI) is one of the most important therapeutic goals in patients with old MI (OMI). Although statins are widely used for this purpose, there remains considerable residual risk even after LDL (low-density lipoprotein cholesterol) is well controlled by statins. Approach and Results- We examined clinical impacts of nHDL (nonhigh-density lipoprotein cholesterol) and its major components triglyceride and LDL as residual risks for acute MI recurrence, using the database of our CHART (Chronic Heart Failure Analysis and Registry in the Tohoku District)-2 Study, the largest-scale cohort study of cardiovascular patients in Japan. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312336DOI Listing

Lysosomal Acid Lipase in Lipid Metabolism and Beyond.

Arterioscler Thromb Vasc Biol 2019 Mar 14:ATVBAHA119312136. Epub 2019 Mar 14.

From the Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York.

Lysosomal acid lipase (LAL), encoded by the lipase A ( LIPA) gene, hydrolyzes cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in the cell. The essential role of LAL in lipid metabolism has been confirmed in mice and human with LAL deficiency. In humans, loss-of-function mutations of LIPA cause rare lysosomal disorders, Wolman disease and cholesteryl ester storage disease, in which LAL enzyme-replacement therapy has shown significant benefits in a phase 3 clinical trial. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312136DOI Listing

Effects of Maternal Sildenafil Treatment on Vascular Function in Growth-Restricted Fetal Sheep.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):731-740

From the Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynecology (I.M.I., G.R.P., S.L.M., A. Sutherland, J.M., A.L., B.J.A.), Monash University, Melbourne, Australia.

Objective- The objective of this study was to investigate the effect of intravenous maternal sildenafil citrate (SC) administration on vascular function in growth-restricted fetal sheep. Approach and Results- Fetal growth restriction (FGR) results in cardiovascular adaptations that redistribute cardiac output to optimize suboptimal intrauterine conditions. These adaptations result in structural and functional cardiovascular changes, which may underlie postnatal neurological and cardiovascular sequelae. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312366DOI Listing
April 2019
1 Read

Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):719-730

From the Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences (W.S., C.-L.Z., L.G., L.H., Y.-Y.G., Q.D., L.Z., L.W., X.Y.T., J.-Y.L., Y.H.).

Objective- TFEB (transcription factor EB) was recently reported to be induced by atheroprotective laminar flow and play an anti-atherosclerotic role by inhibiting inflammation in endothelial cells (ECs). This study aims to investigate whether TFEB regulates endothelial inflammation in diabetic db/db mice and the molecular mechanisms involved. Approach and Results- Endothelial denudation shows that TFEB is mainly expressed in ECs in mouse aortas. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312316DOI Listing
April 2019
1 Read
6.000 Impact Factor

Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):e118-e129

From the Department of Molecular and Integrative Physiology (A.C.A., D.J.P.), University of Michigan Medical Center, Ann Arbor.

Objective- Leukocyte flux contributes to thrombus formation in deep veins under pathological conditions, but mechanisms that inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 ( ENTPD1 or Cd39), an ectoenzyme that catabolizes extracellular adenine nucleotides, is embedded on the surface of endothelial cells and leukocytes. We hypothesized that under venous stasis conditions, CD39 regulates inflammation at the vein:blood interface in a murine model of deep vein thrombosis. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312407
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http://dx.doi.org/10.1161/ATVBAHA.119.312407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467508PMC
April 2019
3 Reads

DKK3 (Dikkopf-3) Transdifferentiates Fibroblasts Into Functional Endothelial Cells-Brief Report.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):765-773

From the Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, China (T.C., Y.W., Q.X., L.Z.).

Objective- To determine the role of a cytokine-like protein DKK3 (dikkopf-3) in directly transdifferentiating fibroblasts into endothelial cells (ECs) and the underlying mechanisms. Approach and Results- DKK3 overexpression in human fibroblasts under defined conditions for 4 days led to a notable change in cell morphology and progenitor gene expression. It was revealed that these cells went through mesenchymal-to-epithelial transition and subsequently expressed KDR (kinase insert domain receptor) at high levels. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311919
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http://dx.doi.org/10.1161/ATVBAHA.118.311919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445366PMC
April 2019
6 Reads

Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):704-718

From the State Key Laboratory of Cardiovascular Diseases and Center for Pediatric Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases (Y.H., Y.-W.L., X.-L.Z., J.L., L.X., J.M., P.-H.W., H.Z.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.

Objective- Pulmonary arterial hypertension is characterized by progressive pulmonary vascular remodeling and persistently elevated mean pulmonary artery pressures and pulmonary vascular resistance. We aimed to investigate whether transthoracic pulmonary artery denervation (TPADN) attenuated pulmonary artery (PA) remodeling, improved right ventricular (RV) function, and affected underlying mechanisms. We also explored the distributions of sympathetic nerves (SNs) around human PAs for clinical translation. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311992DOI Listing
April 2019
2 Reads
6.000 Impact Factor

Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs In Vivo.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):741-753

From the Department of Cardiovascular Medicine (H.A., Y.M., S. Morosawa, K.O., H.U., M. Hirano, K.N., S. Miyata, H.S.), Tohoku University Graduate School of Medicine, Sendai, Japan.

Objective- We have previously demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of coronary vasomotion abnormalities, including drug-eluting stent (DES)-induced coronary hyperconstricting responses. Importantly, the adventitia also harbors lymphatic vessels, which may prevent inflammation by transporting extravasated fluid and inflammatory cells. We thus aimed to examine the roles of coronary adventitial lymphatic vessels in the pathogenesis of DES-induced coronary hyperconstricting responses in a porcine model in vivo. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312396DOI Listing
April 2019
4 Reads

Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):665-674

Department of Internal Medicine and Medical Specialties (I.M., A.D.C., L.D., M.A.), Sapienza University of Rome, Italy.

Objective- Loss-of-function (LOF) variants in the ANGPTL3 (angiopoietin-like protein 3) have been associated with low levels of plasma lipoproteins and decreased coronary artery disease risk. We aimed to determine detailed metabolic effects of genetically induced ANGPTL3 deficiency in fasting and postprandial state. Approach and Results- We studied individuals carrying S17X LOF mutation in ANGPTL3 (6 homozygous and 32 heterozygous carriers) and 38 noncarriers. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312021
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http://dx.doi.org/10.1161/ATVBAHA.118.312021DOI Listing
April 2019
3 Reads

Novel Antiatherosclerotic Therapies.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):538-545

From the Division of Cardiovascular Medicine (P.L., B.M.E.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Many measures can control lipid risk factors for atherosclerosis. Yet, even with excellent control of dyslipidemia, other sources of risk remain. Hence, we must look beyond lipids to address residual risk. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.310958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436984PMC
April 2019
6 Reads

Brain Vasculature and Cognition.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):593-602

Ralph Johnson Veterans Administration Medical Center (A.E.), Medical University of South Carolina, Charleston.

There is a complex interaction between the brain and the cerebral vasculature to meet the metabolic demands of the brain for proper function. Preservation of cerebrovascular function and integrity has a central role in this sophisticated communication within the brain, and any derangements can have deleterious acute and chronic consequences. In almost all forms of cognitive impairment, from mild to Alzheimer disease, there are changes in cerebrovascular function and structure leading to decreased cerebral blood flow, which may initiate or worsen cognitive impairment. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311906DOI Listing
April 2019
4 Reads

Updates of Recent Aortic Aneurysm Research.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):e83-e90

Saha Cardiovascular Research Center (A.D., H.S.L.), University of Kentucky, Lexington.

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http://dx.doi.org/10.1161/ATVBAHA.119.312000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394847PMC

Ironing-Out the Role of Hepcidin in Atherosclerosis.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):303-305

From the CVPath Institute, Gaithersburg, MD (L.G., A.S., A.C., A.V.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312369
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http://dx.doi.org/10.1161/ATVBAHA.119.312369DOI Listing
March 2019
6 Reads

KLF11 (Krüppel-Like Factor 11) Modulates Arterial Thrombosis.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):309-310

From the University of Cincinnati, OH.

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http://dx.doi.org/10.1161/ATVBAHA.119.312368DOI Listing
March 2019
1 Read

Where There Is Smoke, There Is Fire.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):306-308

From the Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch (A.W., A.T.R.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1161/ATVBAHA.119.312398DOI Listing
March 2019
2 Reads

Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):754-764

From the Vascular Biology and Therapeutics Program (T.H., T.I., H.H., K.Y., H.B., J.M.S., A.K., G.K., T.R.F., J.J.H., B.A.Y., W.C.S., A.D.), Yale School of Medicine, New Haven, CT.

Objective- Arteriovenous fistulae (AVF) are the most common access created for hemodialysis; however, many AVF fail to mature and require repeated intervention, suggesting a need to improve AVF maturation. Eph-B4 (ephrin type-B receptor 4) is the embryonic venous determinant that is functional in adult veins and can regulate AVF maturation. Cav-1 (caveolin-1) is the major scaffolding protein of caveolae-a distinct microdomain that serves as a mechanosensor at the endothelial cell membrane. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436985PMC
April 2019
1 Read
6.000 Impact Factor

Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):810-818

Department of Medicine (K.S.A., N.A.Z., M.C.), Larner College of Medicine at the University of Vermont, Burlington.

Objective- Increased Lp(a) [lipoprotein(a)] is associated with coronary heart disease risk, but links with stroke are less consistent. Blacks have higher Lp(a) levels and stroke incidence than whites but have been underrepresented in studies. We hypothesized that Lp(a) is a risk factor for ischemic stroke and that risk differs by race. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311857DOI Listing

Nanoparticle Therapy for Vascular Diseases.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):635-646

From the Division of Vascular Surgery, Department of Surgery (A.M.F., J.Y., K.-U.J., N.J.L.), Stanford University School of Medicine, CA.

Nanoparticles promise to advance strategies to treat vascular disease. Since being harnessed by the cancer field to deliver safer and more effective chemotherapeutics, nanoparticles have been translated into applications for cardiovascular disease. Systemic exposure and drug-drug interactions remain a concern for nearly all cardiovascular therapies, including statins, antithrombotic, and thrombolytic agents. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311569
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http://dx.doi.org/10.1161/ATVBAHA.118.311569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436996PMC
April 2019
2 Reads

Antiatherogenic Effect of Resveratrol Attributed to Decreased Expression of ICAM-1 (Intercellular Adhesion Molecule-1).

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):675-684

From the Department of Molecular Biology & Institute of Nanosensor and Biotechnology, Dankook University, Chungnam, South Korea (Y.S., J. Park, W.C., Y.S.K., M.-K.K., B.-E.Y., J. Pyee, H.P.).

Objective- Increasing evidence shows that resveratrol has antiatherogenic effects, but its underlying mechanisms are unknown. Thus, we evaluated the molecular mechanisms underlying the antiatherogenic effect of resveratrol. Approach and Results- Using the previously established mouse atherosclerosis model of partial ligation of the left carotid artery, we evaluated the role of resveratrol in antiatherosclerosis. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312201DOI Listing
April 2019
1 Read

Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):685-693

From the Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany (E.P.C.v.d.V., M. Mandl, M. Müller, C.N., Y.J., M.H., S.G., L.J.F.P., S.M., O.S., M.D., C.W., Y.D.).

Objective- Expression of the chemokine-like receptor ChemR23 (chemerin receptor 23) has been specifically attributed to plasmacytoid dendritic cells (pDCs) and macrophages and ChemR23 has been suggested to mediate an inflammatory immune response in these cells. Because chemokine receptors are important in perpetuating chronic inflammation, we aimed to establish the role of ChemR23-deficiency on macrophages and pDCs in atherosclerosis. Approach and Results- ChemR23-knockout/knockin mice expressing eGFP (enhanced green fluorescent protein) were generated and after crossing with apolipoprotein E-deficient ( Apoe ChemR23 ) animals were fed a western-type diet for 4 and 12 weeks. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312386DOI Listing
April 2019
1 Read

Diabetes Mellitus and Cardiovascular Disease.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):558-568

From the Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University School of Medicine, New York.

Cardiovascular disease remains a leading cause of morbidity and mortality in people with types 1 or 2 diabetes mellitus. Although beneficial roles for strict control of hyperglycemia have been suggested, such a strategy is not without liabilities. Specifically, the risk of hypoglycemia and its consequences remain an omnipresent threat with such approaches. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.310961DOI Listing

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis.

Arterioscler Thromb Vasc Biol 2019 Feb 21:ATVBAHA119312434. Epub 2019 Feb 21.

From the Departments of Medicine, Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St Paul's Hospital, University of British Columbia, Vancouver, Canada (Y.W., J.A.D., S.A., E.A., B.S., J.E.J., D.D.S., G.A.F.).

Objective- Smooth muscle cells (SMCs) are the most abundant cells in human atherosclerotic lesions and are suggested to contribute at least 50% of atheroma foam cells. In mice, SMCs contribute fewer total lesional cells. The purpose of this study was to determine the contribution of SMCs to total foam cells in apolipoprotein E-deficient (ApoE) mice, and the utility of these mice to model human SMC foam cell biology and interventions. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312434DOI Listing
February 2019
2 Reads

Choosing a Mouse Model of Venous Thrombosis.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):311-318

Department of Surgery, University of Maryland, College Park (B.K.L.).

Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311818DOI Listing
March 2019
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Novel Antiplatelet Therapies for Atherothrombotic Diseases.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):546-557

From the Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA.

Antiplatelet therapies are an essential tool to reduce the risk of developing clinically apparent atherothrombotic disease and are a mainstay in the therapy of patients who have established cardiovascular, cerebrovascular, and peripheral artery disease. Strategies to intensify antiplatelet regimens are limited by concomitant increases in clinically significant bleeding. The development of novel antiplatelet therapies targeting additional receptor and signaling pathways, with a focus on maintaining antiplatelet efficacy while preserving hemostasis, holds tremendous potential to improve outcomes among patients with atherothrombotic diseases. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.310955
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http://dx.doi.org/10.1161/ATVBAHA.118.310955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445601PMC
April 2019
6 Reads

Clinical Utility of CYP2C19 Genotyping to Guide Antiplatelet Therapy in Patients With an Acute Coronary Syndrome or Undergoing Percutaneous Coronary Intervention.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):647-652

From the Division of Cardiology (M.D.K., G.A.S.).

Current guidelines recommend dual antiplatelet therapy-a P2Y inhibitor (clopidogrel, prasugrel, or ticagrelor) and aspirin-for patients undergoing percutaneous coronary intervention. Although clopidogrel is the most commonly prescribed P2Y inhibitor, it is associated with an increased risk of major adverse cardiovascular events in patients carrying loss-of-function CYP2C19 alleles. In contrast, CYP2C19 genotype does not impact clinical response to prasugrel or ticagrelor. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311963DOI Listing
April 2019
1 Read

Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):569-582

From the School of Biomedical Engineering and Imaging Sciences, King's College London, United Kingdom (R.H., T.S.B., C.P., R.M.B.).

Atherosclerosis is the leading cause of cardiovascular morbidity and mortality. Over the past 2 decades, increasing research attention is converging on the early detection and monitoring of atherosclerotic plaque. Among several invasive and noninvasive imaging modalities, magnetic resonance imaging (MRI) is emerging as a promising option. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.311754DOI Listing

Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):623-634

From the Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor.

Cardiometabolic and vascular disease, with their associated secondary complications, are the leading cause of morbidity and mortality in Western society. Chronic inflammation is a common theme that underlies initiation and progression of cardiovascular disease. In this regard, monocytes/macrophages are key players in the development of a chronic inflammatory state. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438376PMC

Chemokines as Therapeutic Targets in Cardiovascular Disease.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):583-592

Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany (C.W., R.R.K.).

With the incidence and impact of atherosclerotic cardiovascular disease and its clinical manifestations still rising, therapeutic options that target the causal mechanisms of this disorder are highly desired. Since the CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) has demonstrated that lowering inflammation can be beneficial, focusing on mechanisms underlying inflammation, for example, leukocyte recruitment, is feasible. Being key orchestrators of leukocyte trafficking, chemokines have not lost their attractiveness as therapeutic targets, despite the difficult road to drug approval thus far. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312037DOI Listing

Inflammasome Signaling and Impaired Vascular Health in Psoriasis.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):787-798

From the Center for the Prevention of Cardiovascular Disease, Department of Medicine (M.S.G., E.A.F., J.S.B.), New York University School of Medicine, New York.

Objective- Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results- Twenty patients (mean age, 40 years; 50% male) with active psoriasis and 10 age-, sex-matched controls were recruited. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436998PMC
April 2019
2 Reads

Recipients of the 2019 Early Career Investigator Awards.

Authors:
Alan Daugherty

Arterioscler Thromb Vasc Biol 2019 Feb 14:ATVBAHA119312479. Epub 2019 Feb 14.

From the Saha Cardiovascular Research Center, University of Kentucky, Lexington.

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http://dx.doi.org/10.1161/ATVBAHA.119.312479DOI Listing
February 2019

Promoters to Study Vascular Smooth Muscle.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):603-612

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).

Smooth muscle cells (SMCs) are a critical component of blood vessel walls that provide structural support, regulate vascular tone, and allow for vascular remodeling. These cells also exhibit a remarkable plasticity that contributes to vascular growth and repair but also to cardiovascular pathologies, including atherosclerosis, intimal hyperplasia and restenosis, aneurysm, and transplant vasculopathy. Mouse models have been an important tool for the study of SMC functions. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312449DOI Listing
April 2019
6 Reads