1,258 results match your criteria Arteries to Brain and Meninges


Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Nat Commun 2018 11 19;9(1):4878. Epub 2018 Nov 19.

Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but this has never been quantitatively shown. We used particle tracking to quantify CSF flow velocities in PVSs of live mice. Read More

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http://dx.doi.org/10.1038/s41467-018-07318-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242982PMC
November 2018
2 Reads

TachoSil Dural Reconstruction in Extracranial-Intracranial Bypass Surgeries.

J Neurol Surg A Cent Eur Neurosurg 2019 Jan 15;80(1):39-43. Epub 2018 Nov 15.

Department of Neurosurgery, BG-Klinikum Bergmannstrost GmbH, Merseburger Straße 165, Halle 06112, Germany.

Background: Superficial temporal artery to middle cerebral artery (STA-MCA) bypass is a treatment option for hemodynamic insufficiency in the anterior cerebral circulation. Complications associated with extracranial-intracranial bypass surgeries are ischemic strokes caused by bypass failure, wound-healing disorders, and further issues from cerebrospinal fluid (CSF) leakage. CSF leakage can provide pathways for infection. Read More

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http://dx.doi.org/10.1055/s-0038-1675565DOI Listing
January 2019
6 Reads

Development of pseudo-subarachnoid hemorrhage secondary to hypoxic-ischemic injury due to bleeding pulmonary arterio-venous malformation.

BMC Neurol 2018 Sep 28;18(1):157. Epub 2018 Sep 28.

Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia.

Background: The computed tomography (CT) finding of a pseudo-subarachnoid hemorrhage (SAH) may lead the treating physician into a diagnostic dilemma. We present a case of a pseudo-SAH in a patient with post-resuscitative encephalopathy, secondary to a newly diagnosed bleeding pulmonary arterio-venous malformation (AVM).

Case Presentation: A 19-year-old female presented acutely with massive hemoptysis. Read More

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http://dx.doi.org/10.1186/s12883-018-1161-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161445PMC
September 2018
3 Reads

Hypertrophic pachymeningoencephalitis associated with temporal giant cell arteritis.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Neurosurgery, Bundeswehrkrankenhaus Westerstede, Westerstede, Germany.

We report the rare case of an 80-year-old male patient with hypertrophic pachymeningoencephalitis that may be associated with temporal arteritis. The patient presented to our neurological department with a 2-week history of latent paresis and ataxia affecting his right hand. He had been diagnosed with temporal arteritis 12 years earlier. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22530
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http://dx.doi.org/10.1136/bcr-2018-225304DOI Listing
September 2018
4 Reads

The Clival Line as an Important Arachnoid Landmark During Endoscopic Third Ventriculostomy: An Anatomic Study.

World Neurosurg 2018 Dec 3;120:e877-e888. Epub 2018 Sep 3.

Department of Neurosurgery, Klinikum Stuttgart, Stuttgart, Germany.

Objective: Endoscopic third ventriculostomy (ETV) is a well-accepted treatment option instead of ventriculoperitoneal shunt placement in cases of obstructive hydrocephalus. A sufficient flow from the ventricles to the basal cisterns requires perforation of the arachnoid membranes in the retroclival region. This point is critical to achieve an optimal outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183196
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http://dx.doi.org/10.1016/j.wneu.2018.08.180DOI Listing
December 2018
6 Reads

Histopathology of Listeria Meningitis.

J Neuropathol Exp Neurol 2018 Oct;77(10):950-957

Department of Neurology, Academic Medical Center, Center of Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands.

Listeria monocytogenes meningitis is the third most common cause of bacterial meningitis in adults and has high mortality and morbidity rates. We describe the clinical course and score brain pathology of 5 patients who died of listeria meningitis. All patients were immunocompromised and ages ranged between 48 and 76 years. Read More

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http://dx.doi.org/10.1093/jnen/nly077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140438PMC
October 2018
37 Reads

The Prognostic Value of CT-Angiographic Parameters After Reperfusion Therapy in Acute Ischemic Stroke Patients With Internal Carotid Artery Terminus Occlusion: Leptomeningeal Collateral Status and Clot Burden Score.

J Stroke Cerebrovasc Dis 2018 Oct 29;27(10):2797-2803. Epub 2018 Jul 29.

Department of Radiology and Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea.

Background: The objective of this study was to investigate the prognostic value of computed tomographic angiography (CTA) based on leptomeningeal collateral (LMC) status and other parameters in acute ischemic stroke (AIS) patients with internal carotid artery (ICA) terminus occlusion treated with endovascular treatment (EVT).

Methods: All eligible patients from January 2013 to December 2017 undergoing EVT were retrospectively reviewed. The regional leptomeningeal score was used to assess the LMCs on baseline CTA. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.010DOI Listing
October 2018
3 Reads

A novel method to isolate retinal and brain microvessels from individual rats: Microscopic and molecular biological characterization and application in hyperglycemic animals.

Vascul Pharmacol 2018 11 9;110:24-30. Epub 2018 Jul 9.

Division of Neurosurgical Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

Alterations in the retinal microvessel (RMV) compartment occurring in systemic disease states such as diabetes may eventually contribute to blindness. To specifically address the pathophysiological role of the microvasculature we developed a new method for RMV bulk isolation from individual rats. The extraction procedure performed in the cold throughout takes less than one hour. Read More

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http://dx.doi.org/10.1016/j.vph.2018.07.001DOI Listing
November 2018
11 Reads

Collateral pial circulation relates to the degree of brain edema on CT 24 hours after ischemic stroke.

Neuroradiol J 2018 Oct 17;31(5):456-463. Epub 2018 Apr 17.

1 Department of Neuroradiology, Centro Hospitalar e Universitário de Coimbra, Portugal.

Background Cerebral edema is frequent in patients with acute ischemic stroke (AIS) who undergo reperfusion therapy and is associated with high mortality. The impact of collateral pial circulation (CPC) status on the development of edema has not yet been determined. Methods We studied consecutive patients with AIS and documented M1-middle cerebral artery (MCA) and/or distal internal carotid artery (ICA) occlusion who underwent reperfusion treatment. Read More

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http://dx.doi.org/10.1177/1971400918769912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136138PMC
October 2018
54 Reads

Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway.

Braz J Med Biol Res 2018 Mar 15;51(5):e6714. Epub 2018 Mar 15.

Department of Anesthesiology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms. Thirty Sprague-Dawley rats received forebrain ischemia for 10 min. The dilation responses of the cerebral pial artery to hypercapnia and hypotension were assessed in rats before and 1 h after ischemia. Read More

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http://dx.doi.org/10.1590/1414-431X20176714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875901PMC
March 2018
8 Reads

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS.

Acta Neuropathol 2018 03 24;135(3):363-385. Epub 2018 Jan 24.

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.

Meninges that surround the CNS consist of an outer fibrous sheet of dura mater (pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the arachnoid and pia mater (leptomeninges) that form the boundaries of the subarachnoid space. In this review we (1) examine the development of leptomeninges and their role as barriers and facilitators in the foetal CNS. Read More

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http://dx.doi.org/10.1007/s00401-018-1809-zDOI Listing
March 2018
6 Reads

Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice.

J Stroke Cerebrovasc Dis 2018 May 11;27(5):1237-1251. Epub 2018 Jan 11.

Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Development of collateral circulation after acute ischemic stroke is triggered by shear stress that occurs in pre-existing arterioles. Recently, sphingosine-1-phosphate receptor 1 (S1P1) on endothelial cells was reported to sense shear stress and transduce its signaling pathways.

Methods: BALB/c mice (n = 118) were subjected to permanent middle cerebral artery occlusion (pMCAO) or sham operation. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.11.040DOI Listing

Molecular characterization of perivascular drainage pathways in the murine brain.

J Cereb Blood Flow Metab 2018 04 28;38(4):669-686. Epub 2017 Dec 28.

1 Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.

Perivascular compartments surrounding central nervous system (CNS) vessels have been proposed to serve key roles in facilitating cerebrospinal fluid flow into the brain, CNS waste transfer, and immune cell trafficking. Traditionally, these compartments were identified by electron microscopy with limited molecular characterization. Using cellular markers and knowledge on cellular sources of basement membrane laminins, we here describe molecularly distinct compartments surrounding different vessel types and provide a comprehensive characterization of the arachnoid and pial compartments and their connection to CNS vessels and perivascular pathways. Read More

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http://dx.doi.org/10.1177/0271678X17749689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888861PMC
April 2018
32 Reads

Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in endemic pemphigus in Colombia, South America.

Int J Dermatol 2018 Mar 20;57(3):291-298. Epub 2017 Nov 20.

Georgia Dermatopathology Associates, Atlanta, GA, USA.

Background: We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF).

Methods: Here we aimed to investigate disease autoreactivity to vessels in all body organs/systems. We compared 57 patients and 57 controls from the endemic area, matched by demographics, age, sex, and work activity. Read More

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http://dx.doi.org/10.1111/ijd.13827DOI Listing
March 2018
11 Reads
1.230 Impact Factor

Loss of Female Sex Hormones Exacerbates Cerebrovascular and Cognitive Dysfunction in Aortic Banded Miniswine Through a Neuropeptide Y-Ca-Activated Potassium Channel-Nitric Oxide Mediated Mechanism.

J Am Heart Assoc 2017 Oct 31;6(11). Epub 2017 Oct 31.

Department of Biomedical Sciences, University of Missouri, Columbia, MO.

Background: Postmenopausal women represent the largest cohort of patients with heart failure with preserved ejection fraction, and vascular dementia represents the most common form of dementia in patients with heart failure with preserved ejection fraction. Therefore, we tested the hypotheses that the combination of cardiac pressure overload (aortic banding [AB]) and the loss of female sex hormones (ovariectomy [OVX]) impairs cerebrovascular control and spatial memory.

Methods And Results: Female Yucatan miniswine were separated into 4 groups (n=7 per group): (1) control, (2) AB, (3) OVX, and (4) AB-OVX. Read More

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http://dx.doi.org/10.1161/JAHA.117.007409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721796PMC
October 2017
11 Reads

Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow.

J Cereb Blood Flow Metab 2018 04 17;38(4):719-726. Epub 2017 Oct 17.

Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands.

Clearance of waste products from the brain is of vital importance. Recent publications suggest a potential clearance mechanism via paravascular channels around blood vessels. Arterial pulsations might provide the driving force for paravascular flow, but its flow pattern remains poorly characterized. Read More

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http://dx.doi.org/10.1177/0271678X17737984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888857PMC
April 2018
1 Read

The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain.

Clin Sci (Lond) 2017 Nov 13;131(22):2745-2752. Epub 2017 Nov 13.

Faculty of Medicine, Institute for Life Sciences, Southampton General Hospital, University of Southampton, South Academic Block, MP806, Tremona Road, Southampton, Hampshire SO166YD, U.K.

Although there are no conventional lymphatic vessels in the brain, fluid and solutes drain along basement membranes (BMs) of cerebral capillaries and arteries towards the subarachnoid space and cervical lymph nodes. Convective influx/glymphatic entry of the cerebrospinal fluid (CSF) into the brain parenchyma occurs along the pial-glial BMs of arteries. This project tested the hypotheses that pial-glial BM of arteries are thicker in the midbrain, allowing more glymphatic entry of CSF. Read More

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http://dx.doi.org/10.1042/CS20171265DOI Listing
November 2017
24 Reads

Glymphatic MRI in idiopathic normal pressure hydrocephalus.

Brain 2017 Oct;140(10):2691-2705

Faculty of Medicine, University of Oslo, Oslo, Norway.

The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71. Read More

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http://dx.doi.org/10.1093/brain/awx191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841149PMC
October 2017
106 Reads

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura.

Dev Cell 2017 09 30;42(5):445-461.e5. Epub 2017 Aug 30.

Department of Neurology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

Dural cerebral veins (CV) are required for cerebrospinal fluid reabsorption and brain homeostasis, but mechanisms that regulate their growth and remodeling are unknown. We report molecular and cellular processes that regulate dural CV development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models. Surprisingly, Twist1 is dispensable in endothelial cells but required for specification of osteoprogenitor cells that differentiate into preosteoblasts that produce bone morphogenetic proteins (BMPs). Read More

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http://dx.doi.org/10.1016/j.devcel.2017.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595652PMC
September 2017
13 Reads

Transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern: an anatomical study.

Acta Neurochir (Wien) 2017 10 14;159(10):1893-1907. Epub 2017 Aug 14.

Department of Neurosurgery, Weill Cornell Medical College, New York Presbyterian Hospital, 525 East 68th St., Box #99, New York, NY, 10065, USA.

Background: The availability of minimal access instrumentation and endoscopic visualization has revolutionized the field of minimally invasive skull base surgery. The transorbital endoscopic approach using an eyelid incision has been proposed as a new minimally invasive technique for the treatment of skull base pathology, mostly extradural tumors. Our study aims to evaluate the anatomical aspects and potential role of the transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern. Read More

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http://link.springer.com/10.1007/s00701-017-3296-8
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http://dx.doi.org/10.1007/s00701-017-3296-8DOI Listing
October 2017
53 Reads

Transdural Indocyanine Green Videography for Superficial Temporal Artery-to-Middle Cerebral Artery Bypass-Technical Note.

World Neurosurg 2017 Oct 12;106:446-449. Epub 2017 Jul 12.

Department of Neurosurgery, Osaka Police Hospital, Osaka, Japan.

Background: Neurosurgical application of indocyanine green (ICG) videography before performing a dural opening, known as transdural ICG videography, has been used during surgery of meningiomas associated with venous sinuses as well as cranial and spinal arteriovenous malformations. However, its use for a superficial temporal artery (STA)-to-middle cerebral artery (MCA) bypass has not been reported.

Methods: We performed a retrospective analysis of medical records of patients who underwent transdural ICG videography during STA-MCA bypass performed between January 2012 and March 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750173110
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http://dx.doi.org/10.1016/j.wneu.2017.07.004DOI Listing
October 2017
37 Reads

Vasculitis in the Central Nervous System.

Adv Exp Med Biol 2017 ;1003:173-185

Department of Neurology, University of Athens Medical School, Aeginition Hospital, Athens, Greece.

Central nervous system (CNS) vasculitides are a heterogeneous group of disorders characterized by an inflammatory cell infiltration and necrosis of blood vessel walls in the brain, spinal cord, and the meninges. The CNS complications are likely to be fatal without judicious use of immunosuppression; thus, early diagnosis may prevent from damage and disability. This chapter updates our knowledge on CNS vasculitis-related immunological mechanisms, neurological complications, diagnosis, and management. Read More

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http://dx.doi.org/10.1007/978-3-319-57613-8_9DOI Listing
October 2017
18 Reads

Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter?

Pediatr Res 2017 Nov 16;82(5):881-887. Epub 2017 Aug 16.

Departments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

BackgroundThe potential contribution of sex-related variables to cerebrovascular functions in neonates remains elusive. Newborn piglets provide a translationally relevant model for studying the effects of seizures in the neonatal brain. The present study investigated whether sex differences contribute to cerebrovascular functions in healthy and epileptic newborn pigs. Read More

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http://dx.doi.org/10.1038/pr.2017.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645245PMC
November 2017
8 Reads

Modelling of subarachnoid space width changes in apnoea resulting as a function of blood flow parameters.

Microvasc Res 2017 09 30;113:16-21. Epub 2017 Mar 30.

Institute of Human Physiology, Medical University of Gdansk, Gdansk, Poland; Institute of Health Sciences, Pomeranian University of Slupsk, Slupsk, Poland.

During apnoea, the pial artery is subjected to two opposite physiological processes: vasoconstriction due to elevated blood pressure and vasorelaxation driven by rising pH in the brain parenchyma. We hypothesized that the pial artery response to apnoea may vary, depending on which process dominate. Apnoea experiments were performed in a group of 19 healthy, non-smoking volunteers (9 men and 10 women). Read More

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http://dx.doi.org/10.1016/j.mvr.2017.03.010DOI Listing
September 2017
5 Reads

The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits.

BMC Anesthesiol 2017 03 7;17(1):38. Epub 2017 Mar 7.

Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 409-3898, Yamanashi, Japan.

Background: Global brain ischemia-reperfusion during propofol anesthesia provokes persistent cerebral pial constriction. Constriction is likely mediated by Rho-kinase. Cerebral vasoconstriction possibly exacerbates ischemic brain injury. Read More

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http://dx.doi.org/10.1186/s12871-017-0331-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341179PMC
March 2017
6 Reads

Rete mirabile associated with pial arteriovenous fistula: imaging features with literature review.

J Neurointerv Surg 2017 Sep 24;9(9):e36. Epub 2017 Feb 24.

Department of Interventional Neuroradiology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, Maharashtra, India.

A rete mirabile is a vascular network of intercommunicating small arteries or arterioles that replace the definitive adult artery supplying the brain. It supplies the brain in lower mammals but is not seen in normal human embryological development. A 26-year-old man presented with worsening tinnitus that was interfering with his sleep. Read More

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http://jnis.bmj.com/lookup/doi/10.1136/neurintsurg-2016-0129
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http://dx.doi.org/10.1136/neurintsurg-2016-012939.repDOI Listing
September 2017
14 Reads

The use of diffusion weighted imaging to evaluate pathology outside the brain parenchyma in neuroimaging studies.

Br J Radiol 2017 Apr 14;90(1072):20160821. Epub 2017 Feb 14.

2 Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, UK.

Diffusion-weighted imaging (DWI) has transformed the radiological assessment of a variety of cerebral pathologies, in particular acute stroke. In neuroimaging studies, DWI can also be used to evaluate pathology outside the brain parenchyma, although it is sometimes underutilized for this purpose. In this pictorial review, the principles of DWI are outlined, and 13 cases of abnormal diffusion outside the brain parenchyma are illustrated in order to show DWI as a useful sequence for the evaluation of the following recommended review areas: the dural venous sinuses, internal carotid arteries, meninges, ventricles, cavernous sinus and orbits, skull base and lymph nodes. Read More

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http://dx.doi.org/10.1259/bjr.20160821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605072PMC
April 2017
1 Read

Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes.

Diab Vasc Dis Res 2017 01 14;14(1):33-39. Epub 2016 Nov 14.

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.

Our goal was to test the hypothesis that administration of tetrahydrobiopterin (BH) would improve impaired endothelial nitric oxide synthase-dependent dilation of cerebral arterioles during type 1 diabetes. In addition, we examined the influence of BH on levels of superoxide in brain tissue. In vivo diameter of cerebral arterioles in nondiabetic and diabetic rats was measured in response to endothelial nitric oxide synthase-dependent agonists (acetylcholine and adenosine 5'-diphosphate) and an endothelial nitric oxide synthase-independent agonist (nitroglycerine) before and during application of BH (1. Read More

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http://dx.doi.org/10.1177/1479164116675490DOI Listing
January 2017
4 Reads

Chronic exposure to water-pipe smoke induces cardiovascular dysfunction in mice.

Am J Physiol Heart Circ Physiol 2017 Feb 9;312(2):H329-H339. Epub 2016 Dec 9.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Sultanate of Oman.

Water-pipe tobacco smoking is becoming prevalent in all over the world including Western countries. There are limited data on the cardiovascular effects of water-pipe smoke (WPS), in particular following chronic exposure. Here, we assessed the chronic cardiovascular effects of nose-only WPS exposure in C57BL/6 mice. Read More

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http://dx.doi.org/10.1152/ajpheart.00450.2016DOI Listing
February 2017
2 Reads
3.838 Impact Factor

High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging.

Sci Rep 2016 12 9;6:38786. Epub 2016 Dec 9.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.

Noninvasive microvascular imaging using optical coherence Doppler tomography (ODT) has shown great promise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open quest. A high-speed 1.3 μm swept-source ODT (SS-ODT) system is reported which was based on a 200 kHz vertical-cavity-surface-emitting laser. Read More

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http://dx.doi.org/10.1038/srep38786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146972PMC
December 2016
7 Reads

Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor.

Brain Res 2017 01 16;1655:48-54. Epub 2016 Nov 16.

Department of Anesthesiology, University of Illinois at Chicago, 1740 W Taylor St, Chicago 60612, IL, USA.

Streptozotocin (STZ)-induced chronic hyperglycemia has a detrimental effect on neurovascular coupling, linked to increased PKC-mediated phosphorylation and PKC isoform expression changes. Here, we sought to determine whether: 1) selective PKC-α/β/γ inhibitor, GF109203X, could reverse the effects of chronic hyperglycemia on cerebrovascular reactivity; 2) pancreatic islet transplantation could prevent the development of cerebrovascular impairment seen in a rat model of Type 1 Diabetes. We studied the effect of GF109203X in diabetic (DM), non-diabetic (ND), and transplanted (TR) Lewis rats during either sciatic nerve stimulation (SNS) or the topical applications of the large-conductance Ca-operated K(BK) channel opener, NS1619, or the K inward rectifier (Kir) channel agonist, KCl. Read More

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http://dx.doi.org/10.1016/j.brainres.2016.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195876PMC
January 2017
7 Reads

Surgical Outcome for Moyamoya Disease: Clinical and Perfusion Computed Tomography Correlation.

World Neurosurg 2017 Feb 31;98:81-88. Epub 2016 Oct 31.

Divsion of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong. Electronic address:

Objectives: To compare surgical outcome both radiologically and clinically after interventions for patients with Moyamoya disease.

Methods: This retrospective observational study included 25 patients who were treated surgically for Moyamoya disease in the past 14 years. Clinical outcomes were analyzed by subgroups stratified by age, disease presentation, and surgical intervention. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.10.117DOI Listing
February 2017
4 Reads

Can blockage or sacrifice of the middle meningeal artery lead to hydrocephalus?

Childs Nerv Syst 2016 Nov 14;32(11):2153-2157. Epub 2016 Mar 14.

Goodman Campbell Brain and Spine, Indiana University Department of Neurological Surgery, Indianapolis, IN, USA.

Background: The middle meningeal artery (MMA) is often sacrificed during neurosurgical procedures in the region of the pterion. This maneuver, herein, is hypothesized to be a potential reason for the development of postoperative hydrocephalus by injuring the vascular supply to the arachnoid granulations near the vertex of the skull, and thus disrupting their ability to allow for transfer of CSF from the subarachnoid space to the venous system.

Materials And Methods: To test this theory, the middle meningeal artery was isolated at the skull base and injected with India ink. Read More

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http://dx.doi.org/10.1007/s00381-016-3058-6DOI Listing
November 2016
3 Reads

Neuronavigated Fiber Dissection with Pial Preservation: Laboratory Model to Simulate Opercular Approaches to Insular Tumors.

World Neurosurg 2017 Feb 17;98:239-242. Epub 2016 Oct 17.

Department of Neurosurgery, Lariboisière Hospital, APHP, Paris, France; University Paris 7, Paris, France; Laboratory of Experimental Neurosurgery, Paris, France.

Background: Advances in the oncologic and functional results of insular surgery have been reported recently. Such successes have been made possible by the advent of the transopercular approach under awake monitoring and by improved anatomic and functional knowledge of white matter pathways surrounding the insula. Nonetheless, given the rarity of insular tumors, it is difficult to get familiar with the complex 3-dimensional anatomy of the different neuronal and vascular structures encountered during a transopercular insular resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750163100
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http://dx.doi.org/10.1016/j.wneu.2016.10.020DOI Listing
February 2017
15 Reads

[Clinical aspects and diagnostics of cerebral vasculitis].

Radiologe 2016 Oct;56(10):890-897

Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Deutschland.

Clinical/methodical Issue: Vasculitis is a rare cause of diseases of the central nervous system (CNS). Vasculitis can be divided into primary and secondary forms, of which the vast majority can be manifested in various organ systems, including the CNS. Isolated vasculitis of the CNS is limited to the CNS and clinical neurological symptoms as with the other forms of vasculitis, are headaches, encephalopathy, focal deficits and seizures. Read More

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http://dx.doi.org/10.1007/s00117-016-0171-1DOI Listing
October 2016
1 Read

[Sporadic Cerebral Amyloid Angiopathy: An Overview with Clinical Cases].

Fortschr Neurol Psychiatr 2016 Sep 8;84(9):534-41. Epub 2016 Sep 8.

Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Klinikum der Universität München.

Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease in the elderly. Neuropathologically, it is characterized by deposition of amyloid-ß (Aß) in the wall of small to medium-sized arteries, capillaries and venules of the cerebral cortex and leptomeninges. Over the last years it was recognized as an important cause of spontaneous intracerebral hemorrhage and cognitive deficits in the elderly. Read More

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http://dx.doi.org/10.1055/s-0042-109537DOI Listing
September 2016
5 Reads

Adaptation of the cerebrocortical circulation to carotid artery occlusion involves blood flow redistribution between cortical regions and is independent of eNOS.

Am J Physiol Heart Circ Physiol 2016 10 5;311(4):H972-H980. Epub 2016 Aug 5.

Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; and

Cerebral circulation is secured by feed-forward and feed-back control pathways to maintain and eventually reestablish the optimal oxygen and nutrient supply of neurons in case of disturbances of the cardiovascular system. Using the high temporal and spatial resolution of laser-speckle imaging we aimed to analyze the pattern of cerebrocortical blood flow (CoBF) changes after unilateral (left) carotid artery occlusion (CAO) in anesthetized mice to evaluate the contribution of macrovascular (circle of Willis) vs. pial collateral vessels as well as that of endothelial nitric oxide synthase (eNOS) to the cerebrovascular adaptation to CAO. Read More

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http://dx.doi.org/10.1152/ajpheart.00197.2016DOI Listing
October 2016
5 Reads

In Vivo Evaluation of Customized Aortic Repair Using a Novel Survival Model.

Eur J Vasc Endovasc Surg 2016 Aug 23;52(2):166-72. Epub 2016 Jun 23.

European Vascular Center Aachen-Maastricht, Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address:

Objective: The aim of the study was to evaluate the feasibility and mid-term biological behavior of the novel customized aortic repair (CAR) method for endovascular aneurysm treatment.

Methods: CAR consists of exclusion of an aneurysm from the circulation using a custom-designed dog bone-shaped balloon, followed by aneurysm sac filling with an in situ curing polymer. After curing and balloon deflation, the circulation is restored through a patent cast neolumen. Read More

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http://dx.doi.org/10.1016/j.ejvs.2016.05.009DOI Listing
August 2016
2 Reads

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways.

J Cereb Blood Flow Metab 2017 Apr 1;37(4):1374-1385. Epub 2016 Jan 1.

1 Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands.

Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Read More

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http://dx.doi.org/10.1177/0271678X16655550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453458PMC
April 2017
5 Reads

Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact.

Microvasc Res 2016 09 7;107:83-90. Epub 2016 Jun 7.

Naval Medical Research Center, NeuroTrauma Department, 503 Robert Grant Avenue Silver Spring, MD 20910, USA; Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD 20814, USA. Electronic address:

Sanguinate, a polyethylene glycol-conjugated carboxyhemoglobin, was investigated for cerebral vasoactivity in healthy male Sprague-Dawley rats (Study 1) and for its ability to increase brain tissue oxygen pressure (PbtO2) after controlled cortical impact (CCI) - traumatic brain injury (TBI) (Study 2). In both studies ketamine-acepromazine anesthetized rats were ventilated with 40% O2. In Study 1, a cranial window was used to measure the diameters of medium - (50-100μm) and small-sized (<50μm) pial arterioles before and after four serial infusions of Sanguinate (8mL/kg/h, cumulative 16mL/kg IV), volume-matched Hextend, or normal saline. Read More

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http://dx.doi.org/10.1016/j.mvr.2016.06.001DOI Listing
September 2016
11 Reads
2 Citations
2.130 Impact Factor

Expanding the Horizon of the Suboccipital Retrosigmoid Approach to the Middle Incisural Space by Cutting the Tentorium Cerebelli: Anatomic Study and Illustration of 2 Cases.

World Neurosurg 2016 Aug 14;92:303-312. Epub 2016 May 14.

Dardinger Microneurosurgical Skull Base Laboratory, Department of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Objective: Complex skull base approaches are often used to treat lesions within the middle incisural space; yet the well-known retrosigmoid route may provide an effective avenue to this difficult-to-reach region. The purpose of this study was to quantify the exposure advantages on the middle incisural space provided by cutting of the tentorium cerebelli via a standard suboccipital retrosigmoid approach (i.e. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.05.020DOI Listing
August 2016
15 Reads
2.420 Impact Factor

Middle Meningeal Artery Embolization in Recurrent Chronic Subdural Hematoma Combined with Arachnoid Cyst.

Korean J Neurotrauma 2015 Oct 31;11(2):187-90. Epub 2015 Oct 31.

Department of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.

Chronic subdural hematoma (CSDH) is a collection of old blood and its breakdown products between the surface of the brain parenchyma and the outermost layer called the dura. The most common treatment option for primary CSDH is burr-hole trephination; however, the treatment method for recurrent CSDH is still widely debated. An arachnoid cyst (AC) is a sac filled with cerebrospinal fluid located between the brain or spinal cord and the arachnoid membrane, which is one of the three meninges covering the brain or spinal cord. Read More

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http://dx.doi.org/10.13004/kjnt.2015.11.2.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847502PMC
October 2015
26 Reads

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

Neuroscience 2016 07 4;328:165-83. Epub 2016 May 4.

University of Lund, Institute of Clinical Sciences at Lund University Hospital, House A13, Sölvegatan, Lund 22184, Sweden.

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodies against CGRP and its binding site at the receptor are clinically effective in preventing migraine attacks. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2016.04.046DOI Listing
July 2016
24 Reads

Unusual case of intracranial dural AV fistula presenting with acute myelopathy.

BMJ Case Rep 2016 Apr 27;2016. Epub 2016 Apr 27.

Department of Neurosurgery, Ninewells Hospital, Dundee, UK.

We present a case of intracranial arteriovenous fistula with perimedullary venous drainage presenting with acute myelopathy, which is an unusual presentation of this uncommon condition. Subsequent catheter angiogram defined the arterial feeders from the meningohypophyseal trunk and petrosal branch of the middle meningeal artery. The patient was successfully embolised, resulting in complete obliteration of the fistula, and significant resolution of brainstem and cervical cord changes along with clinical improvement. Read More

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http://dx.doi.org/10.1136/bcr-2016-215227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854136PMC
April 2016
3 Reads

Vascular basement membranes as pathways for the passage of fluid into and out of the brain.

Acta Neuropathol 2016 May 14;131(5):725-36. Epub 2016 Mar 14.

Faculty of Medicine, University of Southampton, Southampton General Hospital, MP806, Tremona Road, Southampton, Hampshire, SO16 6YD, UK.

In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement membranes in the walls of cerebral capillaries and tunica media of arteries. Perivascular pathways are also involved in the entry of CSF into the brain by the convective influx/glymphatic system. The objective of this study is to differentiate the cerebral vascular basement membrane pathways by which fluid passes out of the brain from the pathway by which CSF enters the brain. Read More

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http://dx.doi.org/10.1007/s00401-016-1555-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835509PMC
May 2016
11 Reads
7 Citations
10.760 Impact Factor

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain.

Brain 2016 Mar 8;139(Pt 3):807-15. Epub 2016 Feb 8.

1 Centre for Brain Research, Medical University of Vienna, Austria

Multiple sclerosis is a chronic inflammatory disease with primary demyelination and neurodegeneration in the central nervous system. In our study we analysed demyelination and neurodegeneration in a large series of multiple sclerosis brains and provide a map that displays the frequency of different brain areas to be affected by these processes. Demyelination in the cerebral cortex was related to inflammatory infiltrates in the meninges, which was pronounced in invaginations of the brain surface (sulci) and possibly promoted by low flow of the cerebrospinal fluid in these areas. Read More

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http://dx.doi.org/10.1093/brain/awv398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766379PMC
March 2016
5 Reads

A review on the management of migraine in the Avicenna's Canon of Medicine.

Neurol Sci 2016 Mar 9;37(3):471-8. Epub 2016 Feb 9.

Department of Phytopharmaceuticals (Traditional Pharmacy), Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Migraine is a common type of headache which has a deep history dating back thousands of years. Avicenna (980-1032), a Persian scholar, made a great contribution to neurology including headache and migraine. The aim of this study is to consider Avicenna's description about migraine (Shaghighe in Persian language) including definition, etiology and intervention. Read More

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http://dx.doi.org/10.1007/s10072-016-2498-9DOI Listing
March 2016
19 Reads

Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats.

Brain Res 2016 Mar 7;1634:171-178. Epub 2016 Jan 7.

Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL, United States.

S100B is an astrocyte-derived protein that can act through the receptor for advanced glycation endproducts (RAGE) to mediate either "trophic" or "toxic" responses. Its levels increase in many neurological conditions with associated microvascular dysregulation, such as subarachnoid hemorrhage (SAH) and traumatic brain injury. The role of S100B in the pathogenesis of microvasculopathy has not been addressed. Read More

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http://dx.doi.org/10.1016/j.brainres.2015.12.061DOI Listing
March 2016
11 Reads

Microsurgical Approaches to the Ambient Cistern Region: An Anatomic and Qualitative Study.

World Neurosurg 2016 Mar 4;87:584-90. Epub 2015 Nov 4.

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.

Objective: We used microscopy to conduct qualitative and quantitative analysis of 4 surgical approaches commonly used in the surgery of the ambient cistern: infratentorial supracerebellar (SC), occipital interhemispheric, subtemporal (ST), and transchoroidal (TC). In addition, we performed a parahippocampal gyrus resection in the ST context.

Methods: Each approach was performed in 3 cadaveric heads (6 sides). Read More

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http://dx.doi.org/10.1016/j.wneu.2015.10.063DOI Listing
March 2016
53 Reads

[Case of Takayasu arteritis accompanying hypertrophic pachymeningitis].

Rinsho Shinkeigaku 2015 28;55(12):940-2. Epub 2015 Oct 28.

Department of Neurology, Tohoku Pharmaceutical University Hospital.

A 71-year-old woman was referred to our department for evaluation of a right temporal headache. She had been diagnosed with Takayasu arteritis in her twenties but did not receive steroid therapy. A brain MRI scan detected thickened dura mater with abnormal enhancement on the right cerebral hemisphere. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-000759DOI Listing
December 2016
2 Reads