Search Our Scientific Publications & Authors

J Plast Reconstr Aesthet Surg 2019 Jan 15. Epub 2019 Jan 15.

Department of Plastic Surgery, West Wing, John Radcliffe Hospital, Oxford University Hospitals, Oxford, OX3 9DU, United Kingdom.

Background: A comprehensive understanding of the anatomy of the vascular supply of the coracoid is needed to ensure that the coracoid remains vascularised in order to optimize bone union during any coracoid transfer procedures. It is the purpose of this study to present an anatomical overview of the blood supply of the coracoid process, describing a previously unidentified vessel that arises directly from the axillary artery and nourishes the coracoid process, permitting the coracoid to be used as a free bone flap.

Methods: An anatomical study examining the blood supply to the coracoid process of the scapula was performed in 14 shoulders from 7 fresh frozen (unembalmed) adult cadavers. Read More

J Vis Exp 2019 Jan 7(143). Epub 2019 Jan 7.

Department of Urology, Ghent University Hospital.

Urethroplasty is considered to be the standard treatment for urethral strictures since it provides excellent long-term success rates. For isolated short bulbar or posterior urethral strictures, urethroplasty by excision and primary anastomosis (EPA) is recommended. As EPA only requires the excision of the narrowed segment and the surrounding spongiofibrosis, a full-thickness transection of the corpus spongiosum, as performed in the traditional transecting EPA (tEPA), is usually unnecessary. Read More

Dermatology 2019 16;235(2):156-163. Epub 2019 Jan 16.

Área de Anatomía y Embriología Humana, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.

Objective: Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. Read More

Ann Anat 2019 Jan 6;221:115-124. Epub 2018 Oct 6.

Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Objectives: The aim of this study was to provide a comprehensive overview of the clinically relevant anatomical and histological aspects of the development of the human pancreas, with emphasis on the vascularization of the gland.

Methods: A comprehensive search on the relevant aspects of pancreatic biology was performed through the main electronic databases up to August 2017. Data from all relevant articles was gathered, analyzed and included in this narrative review. Read More

Surg Radiol Anat 2018 Oct 1;40(10):1173-1175. Epub 2018 Aug 1.

Faculty of Medicine, University of Montenegro, Ljubljanska 1, 20000, Podgorica, Montenegro.

The middle cerebral artery, a terminal branch of the internal carotid artery, participates greatly in the blood supply of the cerebral cortex and basal nuclei. The aim of this paper is to present a case of middle cerebral artery duplication in a 3-day-old neonate. A brief literature overview in this paper serves to summarize the research on the middle cerebral artery duplication. Read More

Radiol Clin North Am 2018 Jul;56(4):521-534

Department of Radiology and Radiological Science, Division of Cardiovascular Imaging, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA. Electronic address:

Dual energy computed tomography is becoming increasingly widespread in clinical practice. It can expand on the traditional density-based data achievable with single energy computed tomography by adding novel applications to help reach a more accurate diagnosis. The implementation of this technology in cardiothoracic vascular imaging allows for improved image contrast, metal artifact reduction, generation of virtual unenhanced images, virtual calcium subtraction techniques, cardiac and pulmonary perfusion evaluation, and plaque characterization. Read More

World J Gastroenterol 2018 Jun;24(22):2348-2362

Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, Sichuan Province, China.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Read More

Vestn Otorinolaringol 2018;83(2):67-72

Orenburg State Medical University, Ministry of Health of the Russian Federation, Orenburg, Russia, 460000.

The objective of the present work was to overview the currently available literature data on microtopographic anatomy of the anterior portion of the middle ear and the external auditory passage. Manipulations on these structures during miringoplasty surgery appear to be the most difficult and laborious operations because this space is anatomically very narrow and curved; moreover, it contains the important intimate structures of the middle ear and is located very close to the temporomandibular joint. The knowledge of microsurgical anatomy of the anterior part of the middle ear and the external auditory passage is paramount in the context of the improvement of the professional skills of the surgeons. Read More

Curr Opin Pharmacol 2018 04 18;39:105-112. Epub 2018 Apr 18.

1st Department of Cardiology, 'Hippokration' Hospital, University of Athens, Medical School, Athens, Greece. Electronic address:

Peripheral artery disease (PAD) is a vascular problem of diffuse atherosclerosis and is a major cause of cardiovascular morbidity and mortality. Many studies have tried to gain insight into the molecular mechanisms involved in PAD. Lately, highly stable circulating small noncoding RNAs, microRNAs (miRNAs), seem to have disease-specific expression. Read More

Vasc Med 2018 04 19;23(2):163-171. Epub 2018 Feb 19.

1 School of Nursing, University of Minnesota, Minneapolis, MN, USA.

Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. Read More

Diagn Interv Imaging 2018 Mar 9;99(3):123-134. Epub 2018 Feb 9.

Department of Radiology, University Hospitals Paris Nord Val-de-Seine, Beaujon, 92110 Clichy, Hauts-de-Seine, France; University Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France; Inserm U1149, centre de recherche biomédicale Bichat-Beaujon, CRB3, 92110 Paris, France. Electronic address:

Acute mesenteric ischemia is defined as an inadequate blood supply to the gastrointestinal tract resulting in ischemic and inflammatory injury that may progress to necrosis of the bowel wall. Prognosis is poor with a mortality rate greater than 95% without treatment, dropping to around 70% when surgical treatment is performed. Contrast-enhanced computed tomography (CT) has become the cornerstone of the diagnosis by showing features of vascular disorders (occlusion and/or insufficient blood supply) and features of intestinal ischemic injury. Read More

Obes Surg 2018 Jul;28(7):1822-1830

Department of Bariatric Surgery, Rijnstate Hospital and Vitalys Clinic, Wagnerlaan 55, 6815 AD, Arnhem, The Netherlands.

Purpose: The purposes of the study are to outline the complexity of diagnosing internal herniation after Roux-en-Y gastric bypass (RYGB) surgery and to investigate the added value of computed tomography angiography (CTA) for diagnosing internal herniation.

Materials And Methods: A cadaver study was performed to investigate the manifestations of internal hernias and mesenteric vascularization. Furthermore, a prospective, ethics approved study with retrospective interpretation was conducted. Read More

Int Angiol 2018 Apr 31;37(2):100-111. Epub 2018 Jan 31.

Clinic of Vascular and Internal Diseases, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland.

Introduction: The association of lower limb ischemia (LLI) with disturbances in nutritional status, in respect to over- or undernutrition, is still uncertain. The aim of this study was to present the current state of knowledge on this issue.

Evidence Acquisition: Systematic review of papers published between 2006 and 2018. Read More

Eur Respir Rev 2018 Mar 24;27(147). Epub 2018 Jan 24.

Dept of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands

Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly characterised by a diaphragmatic defect, persistent pulmonary hypertension (PH) and lung hypoplasia. The relative contribution of these three elements can vary considerably in individual patients. Most affected children suffer primarily from the associated PH, for which the therapeutic modalities are limited and frequently not evidence based. Read More

World Neurosurg 2018 Mar 9;111:36-40. Epub 2017 Dec 9.

Department of Neurological Surgery, University of Louisville SOM, Louisville, Kentucky, USA.

Background: Spinal subarachnoid hemorrhage due to rupture of an isolated spinal aneurysm is extremely rare. Patients usually present with symptoms and signs resulting from spinal cord compression. No standard guidelines are available for the treatment of this condition. Read More

Clin Anat 2018 Mar 28;31(2):152-159. Epub 2017 Dec 28.

Pediatric Urology, University of Pittsburgh Medical Center - Hamot Hospital, Erie, Pennsylvania.

In transgender surgery, the ideal neophallus is one that: (a) is constructed using a reproducible procedure, (b) possesses tactile and erogenous sensation, (c) is large and rigid enough (naturally, or using a prosthesis) to permit penetrative intercourse, (d) leaves acceptable donor site morbidity, (e) results in esthetically satisfactory appearance, and (f) allows for voiding while standing. The musculocutaneous latissimus dorsi (MLD) flap has favorable results in the area of neophalloplasty. Among its advantages are acceptable donor site appearance, stiffness sufficient for intercourse, and esthetically satisfactory genital appearance. Read More

J Neurochem 2018 03 27;144(5):527-548. Epub 2017 Nov 27.

Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, 2900, Edouard-Montpetit, Canada.

Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by the presence of co-morbidities like hypertension, obesity and diabetes. Although epidemiological studies have indicated an association between arterial stiffness, cognitive impairment and dementia, the precise effects of stiff arteries on the brain remains obscure. This is because, in humans, arterial stiffness is often accompanied by other factors such as age, high blood pressure, atherosclerosis and inflammation, which could themselves damage the brain independently of stiffness. Read More

Adv Drug Deliv Rev 2017 10 11;120:25-40. Epub 2017 Sep 11.

Division of Vascular Regeneration, Unit of Regenerative Medicine, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Japan; Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Japan. Electronic address:

Chronic critical limb ischemia (CLI) represents an end-stage manifestation of peripheral arterial disease (PAD). CLI patients are at very high risk of amputation and cardiovascular complications, leading to severe morbidity and mortality. Because many patients with CLI are ineligible for conventional revascularization procedures, it is urgently needed to explore alternative strategies to improve blood supply in the ischemic tissue. Read More

J Vasc Surg 2017 11 2;66(5):1612-1620. Epub 2017 Sep 2.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

Objective: The objective of this study was to provide an overview of evidence regarding exercise therapies for patients with lower extremity peripheral artery disease (PAD).

Methods: This manuscript summarizes the content of a lecture delivered as part of the 2016 Crawford Critical Issues Symposium.

Results: Multiple randomized clinical trials demonstrate that supervised treadmill exercise significantly improves treadmill walking performance in people with PAD and intermittent claudication symptoms. Read More

Expert Rev Neurother 2017 08 29;17(8):801-818. Epub 2017 Jun 29.

g Department of Intensive Care , University of Maastricht, Maastricht University Medical Center , Maastricht , The Netherlands.

Introduction: The preterm born infant's ability to regulate its cerebral blood flow (CBF) is crucial in preventing secondary ischemic and hemorrhagic damage in the developing brain. The relationship between arterial blood pressure (ABP) and CBF estimates, such as regional cerebral oxygenation as measured by near-infrared spectroscopy (NIRS), is an attractive option for continuous non-invasive assessment of cerebrovascular autoregulation. Areas covered: The authors performed a literature search to provide an overview of the current literature on various current clinical practices and methods to measure cerebrovascular autoregulation in the preterm infant by NIRS. Read More

Handb Clin Neurol 2017 ;143:5-13

Department of Neurological Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Arteriovenous malformations (AVMs) are vascular deformities involving fistula formation of arterial to venous structures without an intervening capillary bed. Such anomalies can prove fatal as the high arterial flow can disrupt the integrity of venous walls, thus leading to dangerous sequelae such as hemorrhage. Diagnosis of these lesions in the central nervous system can often prove challenging as intracranial AVMs represent a heterogeneous vascular pathology with various presentations and symptomatology. Read More

Handb Clin Neurol 2017 ;143:125-131

Department of Neurosurgery, NYU Langone Medical Center, New York, NY, USA; Center for Advanced Radiosurgery, NYU Langone Medical Center, New York, NY, USA. Electronic address:

Intracranial dural arteriovenous malformations (DAVFs) are relatively uncommon vascular lesions characterized by the direct connection of dural arteries into dural venous sinuses or leptomeningeal veins. Strategies for the treatment of these complex lesions have evolved significantly over the past three decades, and include open surgical disconnection, endovascular embolization, stereotactic radiosurgery (SRS), or a combination of these approaches. Radiosurgical intervention is unique in offering significant benefits to patients while exposing them to few of the risks associated with more invasive interventions. Read More

Ann Vasc Surg 2017 Oct 22;44:424.e1-424.e5. Epub 2017 May 22.

Department of Vascular Surgery, Medical Center Leeuwarden, Leeuwarden, the Netherlands.

Background: Deep wound infections in the groin region can result in an acute or life-threatening condition. Especially, when there is no suitable vein available because of many reasons (e.g. Read More

Vasc Health Risk Manag 2017 8;13:161-168. Epub 2017 May 8.

Division of Vascular and Endovascular Surgery, School of Medicine, Boston University Boston, MA, USA.

Infrainguinal arterial occlusive disease can lead to potentially disabling and limb-threatening conditions. Revascularization may be indicated for claudication, rest pain, or tissue loss. Although endovascular interventions are becoming more prevalent, open surgeries such as endarterectomy and bypass are still needed and performed regularly. Read More

Vasa 2017 Aug 10;46(5):347-353. Epub 2017 May 10.

6 Vascular Institute Central Switzerland, Aarau, Switzerland.

Erectile dysfunction (ED) is an evolving health problem with growing incidence in the ageing male population with potentially predictive value for cardiovascular and other chronic diseases. ED shares the common cardiovascular risk factors. The aetiology of ED is numerous including neurogenic, psychogenic, arteriogenic, and venogenic reasons. Read More

J Cardiovasc Surg (Torino) 2017 08 20;58(4):508-517. Epub 2017 Mar 20.

Centro Vascolare Ticino, Ospedale Regionale di Lugano, Lugano, Switzerland -

The use of drug-eluting stents and of drug-coated balloons have mitigated the prevalence of in-stent restenosis, however in-stent remains a problem that continues to affect the long-term outcomes of femoro-popliteal endovascular therapy. This paper will provide an overview on the latest data with regard to the treatment of femoro-popliteal in-stent restenosis. Read More

Interv Cardiol Clin 2017 04 27;6(2):251-259. Epub 2017 Jan 27.

Department of Cardiovascular Diseases, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7872, San Antonio, TX 78229, USA. Electronic address:

Critical limb ischemia (CLI) remains a significant cause of morbidity and mortality in patients with peripheral arterial disease. Optimal treatment strategies for CLI remain controversial. The only randomized trial comparing surgical with endovascular revascularization suggests no significant difference in limb salvage between open surgical bypass and angioplasty. Read More

J Plast Reconstr Aesthet Surg 2017 Apr 22;70(4):469-477. Epub 2016 Dec 22.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address:

Objective: The popularity of the superficial circumflex iliac artery perforator (SCIP) flap has been limited by factors such as variable vascular anatomy and short arterial pedicle. This article aimed to delineate flap design and harvest strategies based around either the proximal or distal perforators of the superficial circumflex iliac artery (SCIA) and propose a set of strategies that can help deal with the limitations of the flap.

Method: From August 2011 to June 2015, the SCIP flap was used in 80 patients for soft tissue defects at our institution. Read More

J Cardiovasc Surg (Torino) 2016 12 21;57(6):811-816. Epub 2016 Sep 21.

Service of Interventional Radiology, Centro Vascolare Ticino, Ospedale Regionale di Lugano, Lugano, Switzerland -

The endovascular treatment of atherosclerotic disease of the infra-inguinal arteries has changed significantly since the introduction of drug-eluting balloon technology. The role of angioplasty using drug-eluting balloons for lesions of the superficial femoral and popliteal artery is now well established. The positive results of the use of drug-eluting balloons in the above knee segment could not be achieved in the below-the-knee segment. Read More

Can J Cardiol 2016 10 18;32(10 Suppl 2):S388-S396. Epub 2016 Jul 18.

College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas, USA.

Impaired exercise tolerance is a major determinant of decreased quality of life and survival in individuals with cardiovascular disease. The relative contribution that abnormal cardiac, vascular, and skeletal muscle function plays in limiting exercise tolerance and its improvement with exercise training in patients with cardiovascular disease is not fully known. In this review, we provide an overview of the functional impairment of these systems as they relate to exercise capacity and the emerging role of magnetic resonance imaging as a comprehensive tool to evaluate mechanisms that may explain exercise intolerance. Read More

Fortschr Neurol Psychiatr 2016 Sep 8;84(9):534-41. Epub 2016 Sep 8.

Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Klinikum der Universität München.

Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease in the elderly. Neuropathologically, it is characterized by deposition of amyloid-ß (Aß) in the wall of small to medium-sized arteries, capillaries and venules of the cerebral cortex and leptomeninges. Over the last years it was recognized as an important cause of spontaneous intracerebral hemorrhage and cognitive deficits in the elderly. Read More

Acta Radiol 2017 May 30;58(5):542-549. Epub 2016 Sep 30.

1 Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background Understanding the anatomy of the lower extremity veins is essential for successful varicose vein treatment. Computed tomography (CT) venography may be used to obtain a comprehensive overview and detailed information regarding this. Purpose To describe anatomic variations of the lower extremity venous system in patients with varicose veins, using three-dimensional (3D) CT venography. Read More

Scand J Surg 2017 Jun 23;106(2):107-115. Epub 2016 May 23.

Division of Colorectal Surgery, Department of Surgery, College of Medicine, Yonsei University Health System, Seoul, Korea.

Background And Aims: There is a demand for a better understanding of the vascular structures around the right colonic area. Although right hemicolectomy with the recent concept of meticulous lymph node dissection is a standardized procedure for malignant diseases among most surgeons, variations in the actual anatomical vascular are not well understood. The aim of the present review was to present a detailed overview of the vascular variation pertinent to the surgery for right colon cancer. Read More

Int J Obes Suppl 2015 Aug 4;5(Suppl 1):S28-34. Epub 2015 Aug 4.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Université Laval , Quebec, QC, Canada.

Epicardial adipose tissue is a unique fat depot around the heart that shares a close anatomic proximity and vascular supply with the myocardium and coronary arteries. Its accumulation around the heart, measured using various imaging modalities, has been associated with the onset and progression of coronary artery disease in humans. Epicardial adipose tissue is also the only fat depot around the heart that is known to express uncoupling protein 1 at both mRNA and protein levels in the detectable range. Read More

J Cereb Blood Flow Metab 2016 07 18;36(7):1165-85. Epub 2016 Apr 18.

University of Pennsylvania Medical Center, Philadelphia, PA, USA

The brain depends almost entirely on oxidative metabolism to meet its significant energy requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key measure of brain function. Quantification of CMRO2 has helped elucidate brain functional physiology and holds potential as a clinical tool for evaluating neurological disorders including stroke, brain tumors, Alzheimer's disease, and obstructive sleep apnea. Read More

Viszeralmedizin 2015 Dec 1;31(6):414-22. Epub 2015 Dec 1.

Division of Nuclear Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Background: The unique situation of the liver with arterial and venous blood supply and the dependency of the tumor on the arterial blood flow make this organ an ideal target for intrahepatic catheter-based therapies. Main forms of treatment are classical bland embolization (TAE) cutting the blood flow to the tumors, chemoembolization (TACE) inducing high chemotherapy concentration in tumors, and radioembolization (TARE) without embolizing effect but very high local radiation. These different forms of therapies are used in different centers with different protocols. Read More

Radiologe 2016 Mar;56(3):266-74

Sektion für Interventionelle Radiologie, Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

Clinical/methodical Issue: This article gives an overview of the current importance of so-called subintimal recanalization in the lower extremities.

Standard Radiological Methods: The primary technical goal of endovascular interventions in the lower extremities is the endoluminal restoration of blood circulation from the iliac arteries into the feet.

Methodical Innovations: If endoluminal recanalization of e. Read More

J Clin Diagn Res 2015 Dec 1;9(12):AC05-8. Epub 2015 Dec 1.

Attending Physician, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic , Florida, 2950 Cleveland Clinic Blvd. 33331, Weston, Florida, USA .

Introduction: Pulmonary sequestration also known as bronchopulmonary sequestration is a rare disease, with very few case series reviewed in literature. In this study, we review the demographics, presentation, imaging and treatment of pulmonary sequestration in 29 patients from our institution, and provide comparison data from previously published series with an overview of the disease history.

Materials And Methods: Records reviewed for all patients evaluated and treated in our institution with a pathological proven diagnosis of pulmonary sequestration from January 2004 through December 2013. Read More

Diagn Interv Radiol 2016 Mar-Apr;22(2):116-24

Department of Radiology, American University of Beirut, Beirut, Lebanon.

Over the last decade, exponential advances in computed tomography (CT) technology have resulted in improved spatial and temporal resolution. Faster image acquisition enabled renal CT angiography to become a viable and effective noninvasive alternative in diagnosing renal vascular pathologies. However, with these advances, new challenges in contrast media administration have emerged. Read More

Klin Med (Mosk) 2016;94(9):645-50

Over the past few decades, a steady rise in the incidence, morbidity and mortality from cardiovascular diseases has been observed throughout the world. The most common pathology is coronary heart disease (CHD) which, in addition, is responsible for chronic heart failure in more than one third of the cases. Patients with coronary heart disease are in need of early diagnosis and timely treatment. Read More

J Wound Ostomy Continence Nurs 2016 Jan-Feb;43(1):23-31

Wound Guidelines Task ForceChair/Primary Author, Phyllis A. Bonham, PhD, MSN, RN, CWOCN, DPNAP, FAAN, College of Nursing, Medical University of South Carolina, Charleston, South Carolina.Primary Author, Bonny G. Flemister, MSN, RN, CWOCN, APRN, BC, ANP, GNP-BC, Kilgore, Texas.Linda R. Droste, MSN, RN, CWOCN, CBIS, Spinal Cord Injury and Polytrauma Units, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.Jan J. Johnson, MSN, RN, CWOCN, APRN, ANP-BC, Duke University Medical Center, Zebulon, North Carolina.Teresa Kelechi, PhD, MSN, RN, GCCS-BC, CWCN, FAAN, College of Nursing, Medical University of South Carolina, Charleston, South Carolina.Catherine R. Ratliff, PhD, APRN-BC, CWOCN, CFCN, University of Virginia Health System, Charlottesville, Virginia.Myra F. Varnado, BS, RN, CWOCN, CFCN, Wound Care Specialists Metairie, Louisiana.Scribe: Ronald Palmer, Fullerton, California.

The purpose of this article is to provide a summary of the recommendations from the 2014 Guideline for Management of Wounds in Patients With Lower-Extremity Arterial Disease (LEAD), published by the Wound, Ostomy and Continence Nurses Society (WOCN). This article provides an overview of the process used to update and develop the guideline, and specific recommendations from the guideline for assessment, referral for further evaluation, interventions (ie, debridement, dressings, infection, antibiotics, nutrition, pain management, compression issues, medications, surgical options, and adjunctive therapies), and patient education and risk-reduction strategies. The LEAD guideline is a resource for physicians, nurses, therapists, and other healthcare professionals who work with adults who have/or are at risk for wounds due to LEAD. Read More

Drug Discov Ther 2015 Oct;9(5):342-51

Department of Interventional Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Cancer Research Center, Key Laboratory of Cancer Prevention and Therapy.

Transcatheter arterial chemoembolization (TACE) is a minimally invasive procedure to restrict a tumor's blood supply, and TACE has an established role in cancer therapy. An embolic material in the form of microspheres (such as drug-eluting beads) and transarterial radioembolization is effective at treating hepatocellular carcinoma (HCC). Endovascular therapy offers promise for the treatment of tumor thrombi in the portal vein. Read More

Orv Hetil 2015 Nov;156(48):1938-48

I. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

There are two afferent (hepatic artery, portal vein) and one efferent (hepatic veins) systems responsible for the unique circulation of the liver. Given this special form of vasculature, acute, isolated (i.e. Read More

Ann Biomed Eng 2016 Feb 5;44(2):497-507. Epub 2015 Oct 5.

Department of Management Engineering, University of Bologna, Bologna, Italy.

Stenting treatments for the management of disease in the heart, arterial and venous systems, biliary ducts, urethras, ureters, oesophageal tract and prostate have made enormous technical advances since their introduction into clinical use. The progression from metallic to polymer based bio-absorbable stents, coupled with the advances in additive manufacturing techniques, present a unique opportunity to completely re-envision the design, manufacture, and supply chain of stents. This paper looks at current stenting trends and proposes a future where the stent supply chain is condensed from ~150 days to ~20 min. Read More

Hum Gene Ther Clin Dev 2015 Sep 10;26(3):159-64. Epub 2015 Sep 10.

1 Gene Therapy Center, University of Massachusetts Medical School , Worcester, Massachusetts.

Recombinant adeno-associated virus (rAAV) can be delivered to the skeletal muscle of the limb (pelvic or thoracic) by means of regional intravascular delivery. This review summarizes the evolution of this technique to deliver rAAV either via the arterial blood supply or via the peripheral venous circulation. The focus of this review is on applications in large animal models, including preclinical studies. Read More

Neuroradiology 2015 Dec 9;57(12):1181-202. Epub 2015 Sep 9.

Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Arterial spin labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow (CBF). This review provides a practical guide and overview of the clinical applications of ASL of the brain, as well its potential pitfalls. The technical and physiological background is also addressed. Read More

Am J Physiol Heart Circ Physiol 2015 Nov 4;309(9):H1440-52. Epub 2015 Sep 4.

Department of Health Care Sciences, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Blood flow restriction (BFR) training (also known as Kaatsu training) is an increasingly common practice employed during resistance exercise by athletes attempting to enhance skeletal muscle mass and strength. During BFR training, blood flow to the exercising muscle is mechanically restricted by placing flexible pressurizing cuffs around the active limb proximal to the working muscle. This maneuver results in the accumulation of metabolites (e. Read More

Magn Reson Imaging Clin N Am 2015 Aug;23(3):479-93

Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792-3252, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706, USA; Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705-2275, USA; Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, Madison, WI 53705-2281, USA; Department of Emergency Medicine, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.

The magnetic resonance angiography (MRA) toolbox includes a wide array of versatile methods for diagnosis and therapy planning in patients with a variety of upper extremity vascular pathologies. MRA can provide excellent image quality with high spatial and high temporal resolution without the disadvantages of ionizing radiation, iodinated contrast, and operator dependency. Contrast-enhanced techniques are preferred for their robustness, image quality, and shorter scan times. Read More

Int Orthop 2015 Sep 7;39(9):1793-6. Epub 2015 Jul 7.

Heart Centre, Clinical Centre of the University of Sarajevo, Sarajebo, Bosnia and Herzegovina.

Purpose: During knee arthroplasty, the leg is placed in several forced positions, which are mainly uncomfortable for all tissue structures in the region, including the vascular structures. Veins have a weaker quality of the wall structure than arteries, so during the forced position morphological and haemodynamic consequences are expected mainly in the venous system. Conditions of safe aseptic environment for the arthroplasty are in collision with routine intra-operative analysis of local haemodynamics in real time. Read More