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Angiogenesis 2021 Apr 12. Epub 2021 Apr 12.

Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

There are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble factors to and from every tissue. The lymphatic vasculature maintains interstitial fluid homeostasis, transports hematopoietic cells for immune surveillance, and absorbs fat from the gastrointestinal tract. Read More

Int J Mol Sci 2021 Feb 26;22(5). Epub 2021 Feb 26.

Biomedicine, Biotechnology and Public Health Department, Cádiz University, 11519 Cadiz, Spain.

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. Read More

J Gastrointest Cancer 2021 Feb 22. Epub 2021 Feb 22.

Department of Anatomy, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Purpose: Aberrant hepatic artery anatomy is a considerable challenge during pancreatic surgery as it warrants extreme caution for the preservation of vascular supply as well as achievement of R0 resection margin.

Method: We reviewed the literature about the aberrant anatomical variations of the hepatic artery and its relevance during pancreatoduodenectomy and distal pancreatectomy.

Result: Preoperative deliberation of peri-pancreatic vascular anatomy using advanced imaging methods is crucial for surgeons. Read More

J Cardiovasc Surg (Torino) 2021 Apr 26;62(2):124-129. Epub 2021 Jan 26.

Division of Interventional Radiology, Miami Cardiac and Vascular Institute, FIU Herbert Wertheim College of Medicine, Miami, FL, USA.

The aim of this study was to provide a brief overview of the history the multidisciplinary team approach, highlighting the benefit to the patient with critical limb threatening ischemia in relation to health care economics. Furthermore, we provided a description of the requisites and key components, showing how to build a multidisciplinary team. Read More

Expert Opin Drug Deliv 2021 Mar 22;18(3):383-398. Epub 2021 Jan 22.

Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Introduction: Drug-eluting embolic (DEE) microspheres, or drug-eluting beads (DEB), delivered by transarterial chemoembolization (TACE) serve as a therapeutic embolic to stop blood flow to tumors and a drug delivery vehicle. New combinations of drugs and DEE microspheres may exploit the potential synergy between mechanisms of drug activity and local tissue responses generated by TACE to enhance the efficacy of this mainstay therapy.

Areas Covered: This review provides an overview of key drug delivery concepts related to DEE microspheres with a focus on recent technological developments and promising emerging clinical applications as well as speculation into the future. Read More

BMJ Case Rep 2021 Jan 8;14(1). Epub 2021 Jan 8.

Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, Kolkata, West Bengal, India.

Clin Imaging 2021 May 3;73:61-72. Epub 2020 Dec 3.

Diagnostic and Interventional Radiology, Department of Translational Research, University of Pisa, Via Roma, 67, 56126 Pisa, Italy.

Pulmonary sequestration consists of a nonfunctioning mass of lung tissue, either sharing the pleural envelope of the normal lung (intralobar) or with its own pleura (extralobar), lacking normal communication with the tracheobronchial tree and receiving its arterial supply by one or more systemic vessels. It is the second most common congenital lung anomaly according to pediatric case series, but its real prevalence is likely to be underestimated, and imaging plays a key role in the diagnosis and treatment management of the condition and its potential complications. We will give a brief overview of the pathophysiology, clinical presentation and imaging findings of intra- and extralobar pulmonary sequestration, with particular reference to multidetector computed tomography as part of a powerful and streamlined diagnostic approach. Read More

Int J Mol Sci 2020 Nov 26;21(23). Epub 2020 Nov 26.

Radiodiagnostic Institute, University Hospital Ostrava, 708 52 Ostrava, Czech Republic.

(1) Background: The treatment of peripheral arterial disease (PAD) is focused on improving perfusion and oxygenation in the affected limb. Standard revascularization methods include bypass surgery, endovascular interventional procedures, or hybrid revascularization. Cell-based therapy can be an alternative strategy for patients with no-option critical limb ischemia who are not eligible for endovascular or surgical procedures. Read More

J Cardiovasc Surg (Torino) 2021 Feb 28;62(1):59-70. Epub 2020 Oct 28.

Department of Vascular Surgery, Northwest Clinics, Alkmaar, the Netherlands.

Background: Antiplatelet therapy (APT) after interventions for lower extremity artery disease (LEAD) is recommended. However, (inter)national guidelines vary on type and duration of APT. This report aimed to present the results of a survey on antithrombotic prescribing patterns after lower limb interventions in the Netherlands and an overview of the available literature on this topic. Read More

Surg Radiol Anat 2020 Oct 12. Epub 2020 Oct 12.

Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Introduction: Vascularized proximal fibular epiphyseal transfer is a reconstruction method for joints and growing bones. The authors investigated the vascular supply of the proximal fibula, including skin perforators, for suitability in creating an osteocutaneous flap.

Methods: Twenty fresh cadaveric knees were studied using computed tomographic angiography combined with anatomical dissection. Read More

Neurosurg Rev 2020 Sep 21. Epub 2020 Sep 21.

Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, Genoa, Italy.

Moyamoya vasculopathy is a rare chronic cerebrovascular disorder characterized by the stenosis of the terminal branches of the internal carotid arteries and the proximal tracts of anterior and middle cerebral arteries. Although surgical revascularization does not significantly change the underlying pathogenic mechanisms, it plays a pivotal role in the management of affected individuals, allowing to decrease the risk of ischemic and hemorrhagic complications. Surgical approaches may be direct (extracranial-intracranial bypass), indirect, or a combination of the two. Read More

Vasa 2021 Apr 14;50(3):165-173. Epub 2020 Sep 14.

Department of Internal Medicine, Ushioda General Hospital/Clinic, Yokohama, Japan.

This review provides an updated overview of the emerging roles of neopterin derivatives in atherosclerosis. Neopterin, a metabolite of guanosine triphosphate, is produced by interferon-γ-activated macrophages and is expressed at high levels in atheromatous plaques within the human carotid and coronary arteries as well as in the aorta. Plasma concentrations of neopterin are higher in patients with carotid, cerebral, and coronary artery diseases as well as aortic aneurysm. Read More

Neurochirurgie 2020 Nov 11;66(5):378-382. Epub 2020 Aug 11.

Service de neurochirurgie, CHU de Bicêtre, hôpitaux universitaires Paris-Sud, AP-HP, Paris, France.

Introduction: There is of major interest to know the exact anatomical location of artery of Adamkiewicz (AKA) for many spinal microsurgical procedures, so as to avoid postoperative ischemia of the spinal cord, with further devastating clinical impact.

Methods And Results: We detail the interest of preoperative angiography for medullary lesions in our experience. We further report two cases where the AKA was located at the same level and side with the treated lesion. Read More

Handchir Mikrochir Plast Chir 2020 Aug 28;52(4):280-288. Epub 2020 May 28.

AGAPLESION MARKUS KRANKENHAUS, Akademisches Lehrkrankenhaus der Johann Wolfgang Goethe-Universität Frankfurt am Main, Klinik für Plastische, Ästhetische, Wiederherstellungs- und Handchirurgie.

Background:  Anomalies of the radial arterial system can be of importance during harvesting of a radial forearm flap. In particular when using the forearm flap for phalloplasty due to the required dimensions of the flap, sufficient arterial supply is of fundamental importance. In case of a persistent median artery perfusion conditions in the supply area of ​​the A. Read More

Vasc Med 2020 06 2;25(3):235-245. Epub 2020 May 2.

Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA.

Patients with critical limb ischemia have nonhealing wounds and/or ischemic rest pain and are at high risk for amputation and mortality. Accurate evaluation of foot perfusion should help avoid unnecessary amputation, guide revascularization strategies, and offer efficient surveillance for patency. Our aim is to review current modalities of assessing foot perfusion in the context of the practical clinical management of patients with critical limb ischemia. Read More

Circ Res 2020 02 14;126(5):589-599. Epub 2020 Feb 14.

Department of Health Research and Policy, Stanford University, CA (L.T.).

Rationale: Cocoa and its major flavanol component, epicatechin, have therapeutic properties that may improve limb perfusion and increase calf muscle mitochondrial activity in people with lower extremity peripheral artery disease (PAD).

Objective: In a phase II randomized clinical trial, to assess whether 6 months of cocoa improved walking performance in people with PAD, compared with placebo.

Methods And Results: Six-month double-blind, randomized clinical trial in which participants with PAD were randomized to either cocoa beverage versus placebo beverage. Read More

Ann Anat 2020 May 21;229:151461. Epub 2020 Jan 21.

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland; Scanmed St. Raphael Hospital, Krakow, Poland. Electronic address:

Objectives: The aim of this study was to provide a comprehensive overview of the anatomical, histological, and biomechanical aspects of the Achilles tendon.

Methods: A comprehensive search on the relevant aspects of the Achilles tendon was performed through the main electronic databases up to October 2019. Data from relevant articles was gathered, analyzed, and included in this review. Read More

Hand Clin 2020 02;36(1):1-8

Department of Hand and Reconstructive Microsurgery, National University Health System, Level 11, Tower Block 1E Kent Ridge Road, Singapore 119228, Singapore. Electronic address:

The vascular supply of the hand and wrist is derived from the radial and ulnar arteries. This forms a complex network of vessels on the palmar and dorsal surfaces of the hand. Anastomoses and branching patterns of vessels at the level of the carpals, metacarpals, and phalanges form the basis of old and new flap designs. Read More

Handb Clin Neurol 2019 ;166:3-21

Cingulum Neurosciences Institute, Manlius, NY, United States; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States.

A brief review of the history of key observations of cingulate organization, particularly in the limbic system framework, is presented from 1907 to the present. The reasons why it has not played a significant role in neurology reflect the fact that its arterial supply is complex and no cingulate syndrome has been identified. A flat map of its eight subregions and areas is presented as a basis for many subsequent chapters in this volume. Read More

Cells 2019 10 29;8(11). Epub 2019 Oct 29.

Lawrence D. Longo MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California 92350, USA.

Pregnancy complications of preeclampsia and intrauterine growth restriction (IUGR) are major causes of maternal and perinatal/neonatal morbidity and mortality. Although their etiologies remain elusive, it is generally accepted that they are secondary to placental insufficiency conferred by both failure in spiral artery remodeling and uteroplacental vascular malfunction. MicroRNAs (miRNAs) are small no-coding RNA molecules that regulate gene expression at the post-transcriptional level. Read More

Surg Today 2020 Jan 16;50(1):38-49. Epub 2019 Oct 16.

Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Visceral artery aneurysms (VAAs) are rare and affect the celiac artery, superior mesenteric artery, and inferior mesenteric artery, and their branches. The natural history of VAAs is not well understood as they are often asymptomatic and found incidentally; however, they carry a risk of rupture that can result in death from hemorrhage in the peritoneal cavity, retroperitoneal space, or gastrointestinal tract. Recent advances in imaging technology and its availability allow us to diagnose all types of VAA. Read More

Arch Esp Urol 2019 10;72(8):723-728

ORSI Academy. Melle. Belgium. Department of Urology. Onze Lieve Vrouw Hospital. Aalst. Belgium.

The trend towards the organ sparing and robotic assisted surgeries is clear and is going to expand in the future. Hence, the tools surgeons need to facilitate such minimallly invasive approaches are going to be even more important. The Indocyanine green (ICG) is a water-soluble, relatively hydrophobic dye which bounds to plasma protein and can be used intraoperatively as real time contrast agent. Read More

Am J Hypertens 2020 01;33(1):10-18

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Homburg/Saar, Germany.

Arterial hypertension is associated with increased cardiovascular morbidity and mortality. Although blood pressure-lowering therapies significantly reduce the risk of major cardiovascular events, blood pressure control remains unsatisfactorily low. Several device-based antihypertensive therapies have been investigated in patients with treatment-resistant hypertension and in patients unable or unwilling to adhere to antihypertensive medication. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Nov 23;242:47-55. Epub 2019 Aug 23.

Gynecological Oncology Unit, Department of Obstetrics and Gynecology, Multidisciplinary Breast Clinic, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B-2650, Antwerp, Belgium.

In the industrialised world still 34% of the breast cancer patients are surgically treated by a mastectomy. Breast cancer patients in general have a good prognosis and a long-term survival. Therefore, it is important that the treatment doesn't focus only on survival but also on the quality of life. Read More

Cardiovasc Revasc Med 2019 Oct 17;20(10):891-896. Epub 2019 Jul 17.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:

Reproduction 2019 Aug 1. Epub 2019 Aug 1.

M Ribeiro, Laboratorio de Fisiología y Farmacología de la Reproducción, CEFYBO (CONICET, UBA), Buenos Aires, Argentina.

Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. Read More