839,865 results match your criteria Arterial Supply Orbit

Application of a new hyperbaric oxygen therapy protocol in patients with arterial and venous gas embolism due to hydrogen peroxide poisoning.

Undersea Hyperb Med 2021 Second Quarter;48(2):187-193

Department of Emergency Medicine and Research Institute of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Hydrogen peroxide (H2O2) ingestion can cause vascular gas embolism (GE). Hyperbaric oxygen therapy (HBO2) is known to improve neurological abnormalities in patients with arterial gas embolism (AGE). Previously, HBO2 based on the U. Read More

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Computed tomography-based radiomic model at node level for the prediction of normal-sized lymph node metastasis in cervical cancer.

Transl Oncol 2021 May 8;14(8):101113. Epub 2021 May 8.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Zhuhai Precision Medical Center, Zhuhai People's Hospital (affiliated with Jinan University), Zhuhai 519000, China; Beijing Advanced Innovation Centre for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing 100191, China. Electronic address:

Purpose: Radiomic models have been demonstrated to have acceptable discrimination capability for detecting lymph node metastasis (LNM). We aimed to develop a computed tomography-based radiomic model and validate its usefulness in the prediction of normal-sized LNM at node level in cervical cancer.

Methods: A total of 273 LNs of 219 patients from 10 centers were evaluated in this study. Read More

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Polymorphisms in TNFAIP3, but not in STAT4, BANK1, BLK, and TNFSF4, are associated with susceptibility to Takayasu arteritis.

Cell Immunol 2021 May 4;365:104375. Epub 2021 May 4.

Unidad de Investigación, Hospital Juárez de México, México City, Mexico. Electronic address:

Background: Takayasu arteritis (TAK) is considered a rare disease characterized by nonspecific inflammation of the large arteries, especially the aorta and its major branches. Because TAK is an autoimmune disease (AD), it could share susceptibility loci with other pathologies such as systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), among others. Widely explored polymorphisms in non-HLA genes, including TNFAIP3, STAT4, TNFSF4, BANK1, and BLK have been consistently associated with both SLE and RA, but they have not been evaluated in TAK. Read More

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Verification of Ferroptosis and Pyroptosis and Identification of PTGS2 as the Hub Gene in Human Coronary Artery Atherosclerosis.

Free Radic Biol Med 2021 May 8. Epub 2021 May 8.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. Electronic address:

Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to investigate the expression of ferroptosis-related and pyroptosis-related proteins in human coronary arteries and analyse correlation with severity of atherosclerosis and clarify the interactions between proteins and possible mechanisms of atherosclerosis. 40 human coronary artery specimens were employed. Read More

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Hepatic hilar and celiac plexus nerve blocks as analgesia for doxorubicin-eluting bead embolization procedures for hepatocellular carcinoma: A non-blinded randomized clinical trial.

J Vasc Interv Radiol 2021 May 8. Epub 2021 May 8.

Department of Radiodiagnosis, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Purpose: To investigate whether hepatic hilar and celiac plexus nerve blocks provide safe and effective analgesia to patients undergoing doxorubicin-eluting embolics embolization for hepatocellular carcinoma MATERIALS AND METHODS: In this prospective, randomized trial, 92 patients undergoing drug-eluting embolics transarterial chemoembolization (TACE) for hepatocellular carcinoma were enrolled. The control group received standard intraprocedural local anesthetic, intraarterial lidocaine, and intravenous analgesia; the study group (HHCB) underwent hepatic hilar and celiac plexus nerve blockade in addition. Intraarterial lidocaine, intravenous and postprocedural oral narcotics and antiemetics requirements, pain, patient satisfaction, adverse events, and hospital stay were compared. Read More

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Veno-Arterial Extracorporeal Membrane Oxygenation for Pulmonary Embolism after Systemic Thrombolysis.

Semin Thorac Cardiovasc Surg 2021 May 8. Epub 2021 May 8.

Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

Massive pulmonary embolism (PE) is a life-threatening condition with a high mortality. Both systemic thrombolytics and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) have been used in the management of massive PE. However, the safety of VA- ECMO in the setting of recent thrombolytic administration is not clear. Read More

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Editorial for "Can 3D Pseudo-Continuous Territorial Arterial Spin Labeling Diagnose Unilateral Middle Cerebral Artery Stenosis?"

J Magn Reson Imaging 2021 May 11. Epub 2021 May 11.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

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Routine CT Evaluation of Central Vascular Ligation in Patients undergoing Complete Mesocolic Excision for Sigmoid Colon Cancer.

Colorectal Dis 2021 May 11. Epub 2021 May 11.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Koege, Denmark.

Aim: Objective and reproducible quality measures of complete mesocolic excision for colon cancer are currently not available. This study aimed to measure the inferior mesenteric stump length following CME for sigmoid colon cancer and explore surgical, pathological, and oncological outcomes in patients with a stump length of <10 mm vs. ≥10 mm. Read More

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Coronary artery bypass using bilateral internal thoracic artery grafts in polyarteritis nodosa.

J Card Surg 2021 May 11. Epub 2021 May 11.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Polyarteritis nodosa (PAN) affects small- and medium-sized arteries but rarely occurs in coronary artery aneurysms and stenosis. For patients with PAN, coronary artery bypass grafting (CABG) can be challenging, especially with respect to graft selection. We performed CABG using a bilateral internal thoracic artery (ITA) graft for a 21-year-old patient with PAN, with successful postoperative outcomes. Read More

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Rehabilitation of pulmonary arteries: Hybrid treatment in the unilateral absence of the pulmonary artery.

J Card Surg 2021 May 11. Epub 2021 May 11.

Department of Pediatric Cardiology, National Institute of Cardiology Ignacio Chávez, Mexico City, México.

Background: Unilateral abscence of pulmonary artery is a rare congenital heart disease. If these anomaly is unrecognized and treated the risk of pulmonary hypertension in the contralateral lung can be lethal for the patients.

Aims: To report the successful sequential hybrid-surgical approach of two cases of rescue of pulmonary branches only fed by ductus arteriosus. Read More

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Characterization of the B cell receptor repertoire of patients with acute coronary syndrome.

Genes Genomics 2021 May 11. Epub 2021 May 11.

Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No. 63 Huangtang Road, Meijiang District, Meizhou, 514031, People's Republic of China.

Background: Acute coronary syndrome (ACS) is a complex cardiovascular disease whose development involves the dysregulation of adaptive immune responses. Though it has been proven that T cells associate with inflammation in the development of ACS, the function of B cells in disease remains unclear.

Objective: The aim of this study was to reveal the diversity of the B cell receptor (BCR) repertoire of patients with ACS. Read More

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Usefulness of 3D High-resolution Vessel Wall MRI in Diffuse Nonaneurysmal SAH Patients.

Clin Neuroradiol 2021 May 11. Epub 2021 May 11.

Siemens Healthineers Ltd., Seoul, Korea (Republic of).

Purpose: In 15-20% of patients with nontraumatic diffuse subarachnoid hemorrhage (SAH), the initial conventional angiography does not reveal a causative vascular abnormality, such as intracranial aneurysm. In this study, we evaluated clinical utility of 3D high-resolution vessel wall magnetic resonance imaging (HR-VWI) in patients with diffuse nonaneurysmal SAH.

Methods: A total of 17 patients with diffuse nonaneurysmal SAH were included in this retrospective study. Read More

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Primary cilia control endothelial permeability by regulating expression and location of junction proteins.

Cardiovasc Res 2021 May 11. Epub 2021 May 11.

Department of Pathology and Immunology.

Aims: Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair mechano-transduction of WSS and favour vascular disorders. Read More

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Clinical reasoning in anaphylactic shock: addressing the challenges faced by anaesthesiologists in real time: A clinical review and management algorithms.

Eur J Anaesthesiol 2021 May 10. Epub 2021 May 10.

From the Anaesthesiology and Critical Care Medicine Department, DMU PARABOL, Bichat Hospital, AP-HP (AGC, EK, PM, DL), Antibody in Therapy and Pathology, Pasteur Institute, UMR 1222 INSERM, Paris, France (AGC), Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA (AGC), Pulmonology Department, Bichat Hospital, AP-HP, Paris University (CN), INSERM UMR 1152, Paris University, DHU FIRE, Paris (CN, PM), Anaesthesiology and Critical Care Medicine Department, Maison Blanche Hospital, Centre Hospitalier Universitaire de Reims, Reims (JM-M), Anaesthesiology and Critical Care Medicine Department, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg (CT, PM-M), Paris University (PM, DL), EA 3072, Institut de Physiologie, FMTS, Faculté de Médecine de Strasbourg, Université de Strasbourg, Strasbourg (PM-M) and INSERM1148, Paris, France (DL).

Acute hypersensitivity reactions to drugs occur infrequently during anaesthesia and the peri-operative period. When clinical presentation includes the classical triad, erythema, cardiovascular abnormalities and increased airway pressure, the diagnosis is evident and the challenge is to prescribe a therapeutic regimen according to guidelines and to manage refractory signs in a timely manner. In many situations, however, the initial clinical signs are isolated, such as increased airway pressure or arterial hypotension. Read More

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Genetic variants in are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study.

Autoimmunity 2021 May 11:1-8. Epub 2021 May 11.

Laboratório de Imunomodulação e Novas Abordagens Terapêuticas (LINAT), Núcleo de Pesquisa em Inovação Terapêutica - Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.

Introduction: Systemic sclerosis (SSc) is a rare complex disease characterized by vascular damage, autoimmunity, and extensive skin and internal organs fibrosis. Galectin-3 (Gal-3) is encoded by gene (Lectin, Galactoside-Binding, Soluble, 3; 14q22.3) and it has been reported to play a central role in self-tolerance, inflammation, and fibrosis. Read More

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Targeted nanotherapeutics in the prophylaxis and treatment of thrombosis.

Nanomedicine (Lond) 2021 May 11. Epub 2021 May 11.

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.

Currently available anti-thrombotic therapy for the prophylaxis and treatment of arterial and venous thrombosis includes intravenous administration of anti-thrombotic drugs which lead to severe bleeding risks such as cerebral hemorrhage and stroke. Targeting approaches that utilize nanosystems to reach the thrombus sites are emerging to increase the local effect of anti-thrombotic drugs, as well as to decrease these severe bleeding complications by diminishing the systemic availability of these drugs. This review emphasizes the emerging targeted nanomedicines (liposomes, micelles, polymeric nanoparticles, material bases nanoparticles and other biological vectors) for the prophylaxis and treatment of thrombotic events as well as multifunctional nanomedicines for theranostic applications. Read More

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Short and long-term outcome after common femoral artery hybrid procedure in patients with intermittent claudication and chronic limb threatening ischemia.

Vasa 2021 May 11:1-9. Epub 2021 May 11.

Department of Vascular Surgery, Barmherzige Brüder Hospital Regensburg, Germany.

This study aimed to evaluate the differences between the outcomes of patients with intermittent claudication (IC) and chronic limb threatening ischemia (CLTI) who underwent a hybrid procedure comprising common femoral artery endarterectomy and endovascular therapy. This was a retrospective single-center study of all patients with peripheral arterial occlusive disease (PAD) who underwent the hybrid procedure between March 2007 and August 2018. The primary endpoint was primary patency after 7 years. Read More

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Rapidly Progressing Fatal Left Ventricular Pseudoaneurysm After Acute Myocardial Infarction - A Case Report of Delayed Diagnosis.

Heart Surg Forum 2021 Apr 29;24(2):E414-E417. Epub 2021 Apr 29.

Department of Cardiothoracic Surgery, Guangdong Provincial Hospital of Chinese Medicine, People's Republic of China.

Left ventricular pseudoaneurysm (LVPA) is a rare complication of acute myocardial infarction (MI). As pseudoaneurysm is contained by the pericardium alone without involvement of myocardial tissue, LVPA are more prone to rupture and hence necessitates surgical intervention. We report a case of a 60-year-old man with acute MI due to a three-way occlusion in the coronary arteries. Read More

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Preliminary Outcomes of Viabahn Balloon-Expandable Endoprosthesis as Bridging Stent in Renal Arteries During Fenestrated Endovascular Aortic Repair.

J Endovasc Ther 2021 May 11:15266028211012403. Epub 2021 May 11.

Vascular and Endovascular Surgery, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Purpose: To report preliminary outcomes of Viabahn Balloon-Expandable Endoprosthesis (VBX) stent-graft as bridging stent for renal arteries in fenestrated endovascular aneurysm repair (FEVAR).

Materials And Methods: Between 2018 and 2019, patients undergoing FEVAR at 3 referral Italian university hospitals were prospectively collected. During the study period, VBX was the first-line choice as bridging stent for renal arteries. Read More

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A physiologically realistic virtual patient database for the study of arterial haemodynamics.

Int J Numer Method Biomed Eng 2021 May 10:e3497. Epub 2021 May 10.

College of Engineering, Swansea University, UK.

This study creates a physiologically realistic virtual patient database (VPD), representing the human arterial system, for the primary purpose of studying the effects of arterial disease on haemodynamics. A low dimensional representation of an anatomically detailed arterial network is outlined, and a physiologically realistic posterior distribution for its parameters constructed through the use of a Bayesian approach. This approach combines both physiological/geometrical constraints and the available measurements reported in the literature. Read More

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Microvascular and metabolic alterations in retinitis pigmentosa and Stargardt disease.

Acta Ophthalmol 2021 May 10. Epub 2021 May 10.

Department of Ophthalmology, University of Basel, Basel, Switzerland.

Purpose: The aim of our study was to evaluate retinal microvascular changes recorded with optical coherence tomography angiography (OCTA) and the metabolic function measured with retinal oximetry (RO) in patients with retinitis pigmentosa (RP) and Stargardt disease (STGD).

Methods: In this prospective, noninterventional study, OCTA and RO were performed on 107 eyes (56 subjects): 53 eyes diagnosed with RP without the presence of macular oedema (no-ME-RP), 26 eyes with STGD, and 28 control eyes. Main outcome measures were the mean superficial (FAZ-S; mm ) and deep foveal avascular zone (FAZ-D; mm ) measured with OCTA as well as the mean arterial (A-SO ; %), venular (V-SO ; %) oxygen saturation, their difference (A-V SO ; %) and the corresponding mean diameters of the peripapillary retinal arterioles (D-A; μm) and venules (D-V; μm) determined with RO. Read More

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Antiphospholipid antibodies in critically ill COVID-19 patients with thromboembolism: cause of disease or epiphenomenon?

J Thromb Thrombolysis 2021 May 10. Epub 2021 May 10.

School of Dentistry, University of Utah Health, Salt Lake City, Utah, USA.

Coronavirus 2019 disease (COVID-19) is associated with coagulation dysfunction that predisposes patients to an increased risk for both arterial (ATE) and venous thromboembolism (VTE) and consequent poor prognosis; in particular, the incidence of ATE and VTE in critically ill COVID-19 patients can reach 5% and 31%, respectively. The mechanism of thrombosis in COVID-19 patients is complex and still not completely clear. Recent literature suggests a link between the presence of antiphospholipid antibodies (aPLs) and thromboembolism in COVID-19 patients. Read More

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Complications of Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas.

Acta Neurochir Suppl 2021 ;132:123-127

Department of Neurosurgery, University of Toyama, Toyama, Japan.

Aims: To report the endovascular treatment and complications of intracranial and spinal dural arteriovenous (AV) fistulas.

Methods: A retrospective analysis of 863 cases with dural AV fistulas was completed in the nationwide registry study of the Japanese Society of Neuroendovascular Therapy.

Results: Treatments included transarterial/transvenous embolization (TAE/TVE), open surgery, stereotactic radiation, and their combinations. Read More

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January 2021

Posterior Circulation Aneurysms: A Critical Appraisal of a Surgical Series in Endovascular Era.

Acta Neurochir Suppl 2021 ;132:39-45

Neurosurgery Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

The advent of the endovascular era has apparently decreased the role of microneurosurgery for many of the posterior circulation aneurysms. This study consists of a critical appraisal of a retrospective surgical series regarding posterior circulation aneurysms, targeted to define whether microneurosurgery still has a role for some of these. In 28 years, 157 aneurysms were surgically treated, 98 of which ruptured. Read More

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January 2021

Interpretation of Experimental Data is Substantial for Constitutive Characterization of Arterial Tissue.

J Biomech Eng 2021 May 11. Epub 2021 May 11.

Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno University of Technology, Czech Republic.

The paper aims at evaluation of mechanical tests of soft tissues and creation of their representative stress-strain responses and respective constitutive models. Interpretation of sets of experimental results depends highly on the approach to the data analysis. Their common representation through mean and standard deviation may be misleading and give non-realistic results. Read More

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Architecture-Dependent Mechano-Adaptation in Single Vascular Smooth Muscle Cells.

J Biomech Eng 2021 May 11. Epub 2021 May 11.

University of Minnesota - Department of Biomedical Engineering, Nils Hasselmo Hall, Room 7-105, 312 Church St. SE, Minneapolis, MN 55455.

Arteries grow and remodel following mechanical perturbation. Vascular smooth muscle cells (VSMCs) within the artery undergo hyperplasia, hypertrophy, or change their contractility following sustained changes in loading. Experimental evidence suggests that VSMCs grow and remodel to maintain a constant transmural stress, or "target" stress. Read More

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Cadmium-induced hypertension is associated with renal myosin light chain phosphatase inhibition via increased T697 phosphorylation and p44 mitogen-activated protein kinase levels.

Hypertens Res 2021 May 10. Epub 2021 May 10.

Department of Basic Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, Kingston, Jamaica.

Dietary intake of the heavy metal cadmium (Cd) is implicated in hypertension, but potassium supplementation reportedly mitigates hypertension. This study aims to elucidate the hypertensive mechanism of Cd. Vascular reactivity and protein expression were assessed in Cd-exposed rats for 8 weeks to determine the calcium-handling effect of Cd and the possible signaling pathways and mechanisms involved. Read More

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Increased AT receptor expression mediates vasoconstriction leading to hypertension in Snx1 mice.

Hypertens Res 2021 May 10. Epub 2021 May 10.

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China.

Angiotensin II type 1 receptor (ATR) is a vital therapeutic target for hypertension. Sorting nexin 1 (SNX1) participates in the sorting and trafficking of the renal dopamine D receptor, while angiotensin and dopamine are counterregulatory factors in the regulation of blood pressure. The effect of SNX1 on ATR is not known. Read More

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Ventilator-Associated Pneumonia Rabbit Model for Preclinical Drug Development.

Antimicrob Agents Chemother 2021 May 10. Epub 2021 May 10.

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco

Development and validation of large animal models of ventilator-associated pneumonia is needed for testing new drug candidates in a manner mimicking how they will be used clinically. We have developed a new model in which rabbits were ventilated with low-tidal volume and challenged with to recapitulate hallmark clinical features of acute respiratory distress syndrome (ARDS): acute lung injury and inflammation, progressive decrease in arterial oxygen partial pressure to fractional inspired oxygen PaO:FiO, leukopenia, neutropenia, thrombocytopenia, hyperlactatemia, severe hypotension, bacterial dissemination from lung to other organs, multiorgan dysfunction, and ultimately death. We evaluated the predictive power of this rabbit model for antibiotic efficacy testing by determining whether a humanized dosing regimen of meropenem, a potent antipseudomonal β-lactam antibiotic, when administered with or without intensive care unit (ICU)-supportive care (fluid challenge and norepinephrine), could halt or reverse natural disease progression. Read More

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The role of genetics in pulmonary arterial hypertension associated with congenital heart disease.

Rev Esp Cardiol (Engl Ed) 2021 May 7. Epub 2021 May 7.

Unidad de Hipertensión Pulmonar, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.

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