15,886 results match your criteria Arsenical Keratosis


Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

PLoS Negl Trop Dis 2018 Nov 26;12(11):e0006980. Epub 2018 Nov 26.

Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially characterised. This is the case for four of five current drugs used to treat Human African Trypanosomiasis (HAT); eflornithine is a specific inhibitor of ornithine decarboxylase. Read More

View Article
November 2018
1 Read

Extreme enrichment of arsenic and rare earth elements in acid mine drainage: Case study of Wiśniówka mining area (south-central Poland).

Environ Pollut 2019 Jan 29;244:898-906. Epub 2018 Oct 29.

Geochemistry and the Environment Div., Institute of Chemistry, Jan Kochanowski University, 15G Świętokrzyska St, 25-406, Kielce, Poland.

The Wiśniówka rock strip mining area (south-central Poland) with quartzite quarries, acid water bodies and tailings piles is one of the most unique acid mine drainage (AMD) sites throughout the world. This is due to the occurrence of enormous amounts of pyrite unknown in sedimentary formations worldwide. Of the two mineralization zones, one that is the most abundant in arsenical pyrite occurs in the lowermost Upper Cambrian formation of the Podwiśniówka quarry. Read More

View Article
January 2019

Isolation and characterization of aerobic, culturable, arsenic-tolerant bacteria from lead-zinc mine tailing in southern China.

World J Microbiol Biotechnol 2018 Nov 16;34(12):177. Epub 2018 Nov 16.

College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, 100083, People's Republic of China.

Bioremediation of arsenic (As) pollution is an important environmental issue. The present investigation was carried out to isolate As-resistant novel bacteria and characterize their As transformation and tolerance ability. A total of 170 As-resistant bacteria were isolated from As-contaminated soils at the Kangjiawan lead-zinc tailing mine, located in Hunan Province, southern China. Read More

View Article
November 2018
3 Reads

Using mathematical modeling to infer the valence state of arsenicals in tissues: A PBPK model for dimethylarsinic acid (DMA) and dimethylarsinous acid (DMA) in mice.

J Theor Biol 2019 Jan 26;461:215-229. Epub 2018 Oct 26.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA. Electronic address:

Chronic exposure to inorganic arsenic (iAs), a contaminant of water and food supplies, is associated with many adverse health effects. A notable feature of iAs metabolism is sequential methylation reactions which produce mono- and di-methylated arsenicals that can contain arsenic in either the trivalent (III) or pentavalent (V) valence states. Because methylated arsenicals containing trivalent arsenic are more potent toxicants than their pentavalent counterparts, the ability to distinguish between the +3 and +5 valence states is a crucial property for physiologically based pharmacokinetic (PBPK) models of arsenicals to possess if they are to be of use in risk assessment. Read More

View Article
January 2019
2 Reads

Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors.

Nat Commun 2018 10 19;9(1):4347. Epub 2018 Oct 19.

Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 201800, China.

Arsenic trioxide (ATO) is a successful chemotherapeutic drug for blood cancers via selective induction of apoptosis; however its efficacy in solid tumors is limited. Here we repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to allosterically improve the therapeutic efficacy of ATO-based treatment in solid tumors. We find that NDs and ATO are physically separate and functionally target different cellular pathways (autophagy vs. Read More

View Article
October 2018
2 Reads

Removal of arsenite by reductive precipitation in dithionite solution activated by UV light.

J Environ Sci (China) 2018 Dec 4;74:168-176. Epub 2018 Mar 4.

Chemical Engineering Program, Texas A&M University at Qatar, Education City, P.O. BOX 23874, Doha, Qatar; Zachry Department of Civil Engineering, Texas A&M University, College Station, TX 77843-3136, USA. Electronic address:

This study investigates the removal of arsenite (As(III)) from water using dithionite activated by UV light. This work evaluated the removal kinetics of As(III) under UV light irradiation as affected by dithionite dose and light intensity, and characterized the nature of the precipitated solids using XPS and SEM-EDS. Photolysis of dithionite was observed by measuring dithionite concentration using UV absorbance at 315nm. Read More

View Article
December 2018
5 Reads

Speciation analysis of elements accumulated in Cystoderma carcharias from clean and smelter-polluted sites.

Sci Total Environ 2019 Jan 17;648:1570-1581. Epub 2018 Aug 17.

Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague, Technická 3, 166 28 Prague, Czech Republic.

Collections of Cystoderma carcharias sporocarps were sampled from clean and smelter-polluted sites and analyzed for Ag, As, Cd, Cu, Pb, Se, and Zn contents. Concentrations of all elements were significantly higher in samples from the smelter-polluted area. Except for As and Pb, all elements were effectively accumulated in the sporocarps at both clean and polluted sites. Read More

View Article
January 2019

Effect of arsenate on endogenous levels of cytokinins with different existing forms in two Pteris species.

Plant Physiol Biochem 2018 Nov 10;132:652-659. Epub 2018 Oct 10.

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China.

Our previous results showed that content of trans-zeatin (tZ) increases in leaves of heavy metal hyperaccumulators but decreases in non-hyperaccumulators growing in multiple heavy metal polluted soils. However, the relationship between arsenic (As) accumulation and endogenous forms of cytokinins (CTKs) in As hyperaccumulators remains unknown. Here a hydroponic experiment was conducted to compare the CTK forms in the As hyperaccumulator Pteris cretica var. Read More

View Article
November 2018
2 Reads
2.760 Impact Factor

Seed Extract Ameliorates Arsenic-Induced Blood Cell Genotoxicity and Hepatotoxicity in Wistar Albino Rats.

Rep Biochem Mol Biol 2018 Oct;7(1):110-118

Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana.

Background: Arsenic is a well-documented human carcinogen widely distributed in the environment. Chronic exposure of humans to inorganic arsenicals causes many adverse health effects. The present work was conducted to evaluate the protective effect of seed extract (SCE) on arsenic-induced genotoxicity and hepatotoxicity in Wistar albino rats. Read More

View Article
October 2018
1 Read

A novel RGDyC/PEG co-modified PAMAM dendrimer-loaded arsenic trioxide of glioma targeting delivery system.

Int J Nanomedicine 2018 2;13:5937-5952. Epub 2018 Oct 2.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China,

Background: The Traditional Chinese Medicine, arsenic trioxide (ATO, AsO) could inhibit growth and induce apoptosis in a variety of solid tumor cells, but it is severely limited in the treatment of glioma due to its poor BBB penetration and nonspecifcity distribution in vivo.

Purpose: The objective of this study was encapsulating ATO in the modified PAMAM den-drimers to solve the problem that the poor antitumor effect of ATO to glioma, which provide a novel angle for the study of glioma treatment.

Methods: The targeting drug carrier (RGDyC-mPEG-PAMAM) was synthesized based on Arg-Gly-Asp (RGDyC) and αvβ3 integrin targeting ligand, and conjugated to PEGylated fifth generation polyamidoamine dendrimer (mPEG-PAMAM). Read More

View Article
November 2018

Arsenic speciation in aerosols of a respiratory therapeutic cave: A first approach to study arsenicals in ultrafine particles.

Sci Total Environ 2019 Feb 9;651(Pt 2):1839-1848. Epub 2018 Oct 9.

University of Graz, Institute of Chemistry, Analytical Chemistry for Health and Environment, Universitaetsplatz 1, 8010 Graz, Austria. Electronic address:

Arsenic is ubiquitous in the environment and of special concern due to its varying toxicity depending on the chemical form present. Less is known about arsenic in air, especially about organoarsenicals, their sources and fate. There is also a lack of knowledge regarding arsenic in airborne nanoparticles that are critical for understanding with respect to human health effects due to their size. Read More

View Article
February 2019
2 Reads

A novel efflux transporter, ArsK, is responsible for bacterial resistance to arsenite, antimonite, trivalent roxarsone and methylarsenite.

Appl Environ Microbiol 2018 Oct 12. Epub 2018 Oct 12.

State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Arsenic-resistant bacteria have evolved various efflux systems for arsenic resistance. Five arsenic efflux proteins, ArsB, Acr3, ArsP, ArsJ and MSF1, have been reported. In this study, comprehensive analyses were performed to study the function of a putative major facilitator superfamily gene and the regulation of transcriptional expression in GW4. Read More

View Article
October 2018
1 Read

New Sulfur-Containing Polyarsenicals from the New Caledonian Sponge Echinochalina bargibanti.

Mar Drugs 2018 Oct 11;16(10). Epub 2018 Oct 11.

Laboratorio di Chimica Bioorganica, Dipartimento di Fisica, Università di Trento, Via Sommarive 14, I-38123 Trento, Italy.

Arsenicin A (C₃H₆As₄O₃) was isolated from the New Caledonian poecilosclerid sponge , and described as the first natural organic polyarsenic compound. Further bioguided fractionation of the extracts of this sponge led us to isolate the first sulfur-containing organic polyarsenicals ever found in Nature. These metabolites, called arsenicin B and arsenicin C, are built on a noradamantane-type framework that is characterized by an unusual As⁻As bonding. Read More

View Article
October 2018
3 Reads

Biotechnological potential of plant growth-promoting bacteria from the roots and rhizospheres of endemic plants in ironstone vegetation in southeastern Brazil.

World J Microbiol Biotechnol 2018 Oct 4;34(10):156. Epub 2018 Oct 4.

Programa de Pós-graduação em Biotecnologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.

Microorganisms associated with plants have a great biotechnological potential, but investigations of these microorganisms associated with native plants in peculiar environments has been incipient. The objective of this study was to analyze the plant growth-promoting bacteria potential of cultivable bacteria associated with rare plants from the ferruginous rocky fields of the Brazilian Iron Quadrangle. The roots and rhizospheres of nine endemic plants species and samples of a root found in a lateritiric duricrust (canga) cave were collected, the culturable bacteria isolated and prospected for distinct biotechnological and ecological potentials. Read More

View Article
October 2018
2 Reads

Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and intravenous administration.

Food Chem Toxicol 2018 Nov 29;121:676-686. Epub 2018 Sep 29.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. Electronic address:

Arsenic is a ubiquitous contaminant, with typical dietary intake below 1 μg/kg bw/d and drinking water exposures up to 50 μg/kg bw/d. Arsenic exposures are associated with human diseases and doses of toxicological concern are similar to typical dietary intake. Metabolism of arsenite to dimethylarsinate (DMA) by arsenite-3-methyltransferase (As3MT) promotes clearance, but also generates reactive trivalent intermediates that bind extensively to cellular thiols. Read More

View Article
November 2018
5 Reads

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor.

Commun Biol 2018 3;1:128. Epub 2018 Sep 3.

Graduate School of Medicine, Korea University, Seoul, 02841 Republic of Korea.

Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces the activation of the galanin receptor 2 (Galr2) that leads to a robust stimulation toward Gαq-protein and β-arrestin1/2, an alternative ligand Spexin and its analog have biased agonism toward G-protein signaling relative to Galanin. Read More

View Article
September 2018

[Association between Arsenic Intake and Cancer-From the Viewpoint of Epidemiological Study].

Authors:
Norie Sawada

Nihon Eiseigaku Zasshi 2018 ;73(3):265-268

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.

Arsenic is widely distributed in nature, and humans are exposed to arsenic through air, water, beverages, and food. On the bases of previous studies of highly exposed populations, arsenic is designated as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC), and IARC has established a causal role for arsenic in cancers of the urinary bladder, lung, and skin in humans. However, there are very few epidemiological studies of the association between low-moderate arsenic exposure and cancer. Read More

View Article
October 2018
1 Read

Factors Affecting Differential Methylation of DNA Promoters in Arsenic-Exposed Populations.

Biol Trace Elem Res 2018 Sep 15. Epub 2018 Sep 15.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, China.

The exposure/biotransformation of inorganic arsenic (iAs) may perturb DNA methylation patterns and subsequently influence disease risk by altering the expression of key genes. Interindividual variation in patterns of DNA methylation can be explained by the influence of environmental, genetic, and stochastic factors. Here, we examined promoter DNA methylation levels with urinary arsenical concentrations and investigated the genetic and nongenetic determinants of DNA methylation in 105 samples collected from populations in Shanxi Province, China, with high levels of arsenic in drinking water. Read More

View Article
September 2018
8 Reads

Thiolation in arsenic metabolism: a chemical perspective.

Metallomics 2018 Oct;10(10):1368-1382

Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA.

In recent years, methylated thioarsenicals have been widely detected in various biological and environmental matrices, suggesting their broad involvement and biological importance in arsenic metabolism. However, very little is known about the formation mechanism of methylated thioarsenicals and the relation between arsenic methylation and thiolation processes. It is timely and necessary to summarize and synthesize the reported information on thiolated arsenicals for an improved understanding of arsenic thiolation. Read More

View Article
October 2018

Analysis of the ars gene cluster from highly arsenic-resistant Burkholderia xenovorans LB400.

World J Microbiol Biotechnol 2018 Sep 10;34(10):142. Epub 2018 Sep 10.

Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana, Edificio B-3, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico.

The Burkholderia xenovorans LB400 multireplicon genome displays a relatively high proportion of redundant genes, including several genes predicted to be related to arsenic resistance. These comprise an ars gene cluster, composed of the arsR3, acr3, arsC1 and arsH genes, as well as two arsB, arsC2, and seven individual arsR genes. The objective of this work was to elucidate the involvement of the ars gene cluster in arsenic resistance by the LB400 strain. Read More

View Article
September 2018

The role of submerged macrophytes in phytoremediation of arsenic from contaminated water: A case study on Vallisneria natans (Lour.) Hara.

Ecotoxicol Environ Saf 2018 Dec 7;165:224-231. Epub 2018 Sep 7.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, PR China. Electronic address:

Arsenic contamination of water is a global concern due to its heavy threat to human health. In this study, the submerged macrophyte Vallisneria natans (Lour.) Hara was used to remove environmentally relevant concentrations of arsenic in the binary As(III)/As(V) system. Read More

View Article
December 2018
5 Reads

Functional suppression of macrophages derived from THP-1 cells by environmentally-relevant concentrations of arsenite.

Comp Biochem Physiol C Toxicol Pharmacol 2018 Dec 3;214:36-42. Epub 2018 Sep 3.

East China University of Science and Technology, School of Pharmacy, Department of Pharmaceutical Sciences, Shanghai 200237, China; East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai 200237, China; University of New Mexico, Department of Chemistry and Chemical Biology, Albuquerque, NM 87131, USA. Electronic address:

Environmental exposure to arsenic is known to induce immunotoxicity. Macrophages are the professional phagocytes that are important in the immune system. In this study, we utilized the macrophages derived from the THP-1 human monocyte cell line as the experimental model to study the functional suppression induced by arsenite (As), one of the most prevalent forms of inorganic arsenic, at environmentally-relevant concentrations. Read More

View Article
December 2018
2 Reads
2.300 Impact Factor

Phototransformation of p-arsanilic acid in aqueous media containing nitrogen species.

Chemosphere 2018 Dec 20;212:777-783. Epub 2018 Aug 20.

State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, China. Electronic address:

The effects of co-existing nitrogen species in surface water on the phototransformation of organoarsenical p-arsanilic acid (p-ASA) have been investigated using a xenon lamp as a simulated solar light source. Significant enhancements of p-ASA phototransformation efficiency were observed in the presence of nitrate and nitrite, increasing with the concentration of these species and pH, whereas ammonia showed no obvious effect. The products, including inorganic arsenic species and organic derivatives, have been analyzed in order to reveal the phototransformation pathways. Read More

View Article
December 2018
2 Reads

Effects of arsenic on the biofilm formations of arsenite-oxidizing bacteria.

Ecotoxicol Environ Saf 2018 Dec 30;165:1-10. Epub 2018 Aug 30.

State Key Laboratory of Biogeology and Environmental Geology, School of Environmental Studies, China University of Geosciences (Wuhan), Wuhan 430070, People's Republic of China.

Arsenite-oxidizing bacteria (AOB) play a key role in the biogeochemical cycle of arsenic in the environment, and are used for the bioremediation of As contaminated groundwater; however, it is not yet known about how arsenic affects biofilm formations of AOB, and how biofilm formations affect bacterial arsenite-oxidizing activities. To address these issues, we isolated seven novel AOB strains from the arsenic-contaminated soils. They can completely oxidize 1. Read More

View Article
December 2018
2 Reads

The role of GST omega in metabolism and detoxification of arsenic in clam Ruditapes philippinarum.

Aquat Toxicol 2018 Nov 23;204:9-18. Epub 2018 Aug 23.

Key Laboratory of Coastal Zone Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, PR China. Electronic address:

The major hazard of arsenic in living organisms is increasingly being recognized. Marine mollusks are apt to accumulate high levels of arsenic, but knowledge related to arsenic detoxification in marine mollusks is still less than sufficient. In this study, arsenic bioaccumulation as well as the role of glutathione S-transferase omega (GSTΩ) in the process of detoxification were investigated in the Ruditapes philippinarum clam after waterborne exposure to As(III) or As(V) for 30 days. Read More

View Article
November 2018
1 Read
3.450 Impact Factor

Arsenate-dependent growth is independent of an ArrA mechanism of arsenate respiration in the termite hindgut isolate Citrobacter sp. strain TSA-1.

Can J Microbiol 2018 Sep;64(9):619-627

a National Research Program-Western Branch, Water Mission Area, US Geological Survey, Menlo Park, California, USA.

Citrobacter sp. strain TSA-1 is an enteric bacterium isolated from the hindgut of the termite. Strain TSA-1 displays anaerobic growth with selenite, fumarate, tetrathionate, nitrate, or arsenate serving as electron acceptors, and it also grows aerobically. Read More

View Article
September 2018

Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.

J Biol Chem 2018 Oct 28;293(42):16226-16241. Epub 2018 Aug 28.

From the Key Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, and

Slingshots are phosphatases that modulate cytoskeleton dynamics, and their activities are tightly regulated in different physiological contexts. Recently, abnormally elevated Slingshot activity has been implicated in many human diseases, such as cancer, Alzheimer's disease, and vascular diseases. Therefore, Slingshot-specific inhibitors have therapeutic potential. Read More

View Article
October 2018
9 Reads

Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection: NHANES (2003-2014) in U.S. Adults.

Curr Med Sci 2018 Aug 20;38(4):610-617. Epub 2018 Aug 20.

Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Studies concerning the association between arsenic exposure and hepatitis B virus (HB V) infection have been lacking. The present study aimed to examine the association between total urinary arsenic (TUA) and infection of HBV. A total of 5186 participants from National Health and Nutrition Examination Survey (NHANES) 2003-2014 were included in the analysis. Read More

View Article
August 2018
5 Reads

Dual effects of arsenic trioxide on tumor cells and the potential underlying mechanisms.

Oncol Lett 2018 Sep 5;16(3):3812-3820. Epub 2018 Jul 5.

Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

The human ether-a-go-go related gene (hERG) encodes the rapid delayed rectifier K channel. hERG not only serves an important role in heart muscle and cardiomyocyte excitability by regulating action potential repolarization, but also represents a selective advantage for cancer cell proliferation. Arsenic trioxide is a traditional Chinese medicine, which has been previously identified as an efficient tumor suppressor, particularly in the treatment of acute pro-myelocytic leukemia. Read More

View Article
September 2018
1 Read

Enhanced cytotoxic effects of arsenite in combination with anthocyanidin compound, delphinidin, against a human leukemia cell line, HL-60.

Chem Biol Interact 2018 Oct 17;294:9-17. Epub 2018 Aug 17.

Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.

Among five major anthocyanin compounds, delphinidin exhibited the most potent and selective cytocidal effect against HL-60, a trivalent arsenic (As(III))-resistant cell line. Co-treatment with delphinidin and As(III) resulted in the reduction of IC value for As(III) from 11.2 to 1. Read More

View Article
October 2018
7 Reads

Transcriptomic comparison of two barley genotypes differing in arsenic tolerance exposed to arsenate and phosphate treatments.

Plant Physiol Biochem 2018 Sep 7;130:589-603. Epub 2018 Aug 7.

Department of Agronomy, College of Agriculture and Biotechnology, Key Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou, 310058, PR China. Electronic address:

Arsenic (As) is a ubiquitous metalloid and toxic to plants. Chemical similarity between arsenate and phosphate (P) indicates possible antagonism between them in uptake and transportation. However, there is little study to reveal the interaction of As and P at transcriptional level. Read More

View Article
September 2018
25 Reads
2.760 Impact Factor

Facile synthesis of ZrO coated BiOClI for photocatalytic oxidation-adsorption of As(III) under visible light irradiation.

Chemosphere 2018 Nov 2;211:934-942. Epub 2018 Aug 2.

The Key Laboratory of Water and Sediment Sciences, Ministry of Education, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, PR China. Electronic address:

ZrO modified BiOClI composites (ZBCI), synthesized via a facile precipitation method at room temperature, were utilized to photocatalytically oxidize and adsorb arsenite from water under visible light irradiation. The composites were well characterized by using various techniques. With visible light irradiation, 5 mg L of As(III) could be completely removed by ZBCI (0. Read More

View Article
November 2018
7 Reads

Enhanced adsorption of arsenate and antimonate by calcined Mg/Al layered double hydroxide: Investigation of comparative adsorption mechanism by surface characterization.

Chemosphere 2018 Nov 30;211:903-911. Epub 2018 Jul 30.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address:

This study aims to investigate adsorption mechanisms of As(V) and Sb(V) on calcined Mg/Al layered double hydroxide (LDH). The calcination process of Mg/Al LDH (CLDH) considerably enhanced the adsorption capacity of As(V) and Sb(V) via reconstruction and new formation of brandholzite-like compound, respectively. The maximum adsorption capacity for As(V) and Sb(V) by CLDH was 102. Read More

View Article
November 2018
5 Reads

Metals content of recycled construction and demolition wood before and after implementation of best management practices.

Environ Pollut 2018 Nov 2;242(Pt B):1198-1205. Epub 2018 Aug 2.

Department of Environmental Engineering Sciences, University of Florida, P.O. Box 116450, Gainesville, FL, 32611 - 6450, USA. Electronic address:

A limitation to recycling wood from construction and demolition (C&D) waste is contamination of metals from the inadvertent inclusion of preservative treated wood, in particular wood treated with chromated copper arsenate (CCA) and newer copper-based formulations. To minimize contamination many regions have developed best management practices (BMPs) for separating treated from untreated wood. The objective of this study was to evaluate the fraction of preservative treated wood in recycled C&D wood after the implementation of BMPs, using Florida as a case study. Read More

View Article
November 2018
6 Reads

Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations.

Proc Natl Acad Sci U S A 2018 09 13;115(37):E8614-E8623. Epub 2018 Aug 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125;

Arsenate respiration by bacteria was discovered over two decades ago and is catalyzed by diverse organisms using the well-conserved Arr enzyme complex. Until now, the mechanisms underpinning this metabolism have been relatively opaque. Here, we report the structure of an Arr complex (solved by X-ray crystallography to 1. Read More

View Article
September 2018
1 Read

Impact on growth, oxidative stress, and apoptosis-related gene transcription of zebrafish after exposure to low concentration of arsenite.

Chemosphere 2018 Nov 3;211:648-652. Epub 2018 Aug 3.

College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004, People's Republic of China. Electronic address:

Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 μg L) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes. Read More

View Article
November 2018
3 Reads

Trisenox induces cytotoxicity through phosphorylation of mitogen-activated protein kinase molecules in acute leukemia cells.

J Biochem Mol Toxicol 2018 Oct 8;32(10):e22207. Epub 2018 Aug 8.

Cellomics and Toxicogenomics Research Laboratory, NIH/NIMHD-RCMI Center for Environmental Health, College of Science, Engineering and Technology, Jackson, Mississippi.

Trisenox (TX) has been used successfully for the treatment of acute promyelocytic leukemia (APL) patients. TX-induced cytotoxicity in APL cells remains poorly understood. In this study, we investigated the molecular mechanism of TX cytotoxicity using APL cell lines. Read More

View Article
October 2018
2 Reads

Mitochondrial toxicity of organic arsenicals: membrane permeability transition pore opening and respiratory dysfunction.

Toxicol Res (Camb) 2018 Mar 19;7(2):191-200. Epub 2017 Dec 19.

State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , P. R. China . Email: ; ; Tel: +8627 68753465.

In order to clarify the mitochondrial toxicity mechanism of the organic arsenical (2-methoxy-4-(((4-(oxoarsanyl) phenyl) imino) methyl) phenol), research was carried out at the sub-cell level based on the previous finding that the compound can damage the mitochondria by triggering a burst of ROS. After investigating its influence on isolated mitochondria , it was demonstrated that a high dose of with short-term exposure can induce mitochondrial swelling, decrease the membrane potential, enhance the permeability of H and K, and induce membrane lipid peroxidation, indicating that it can result in an MPT process in a ROS-mediated and Ca-independent manner. Additionally, MPT was also aggravated as a result of impairment of the membrane integrity and membrane fluidity. Read More

View Article

Evaluation of metabolic reactivity in macrophages from mice with chronic sodium arsenite intake and experimental carcinogenesis.

Cell Mol Biol (Noisy-le-grand) 2018 Jul 30;64(10):34-39. Epub 2018 Jul 30.

National Atomic Energy Commission (CNEA), Argentina.

 Arsenic is carcinogenic to human beings, and environmental exposure to arsenic is a public health issue that affects large populations around the world. Thus, studies are needed to determine the mode of action of arsenic and to prevent harmful effects that arise from arsenic intake. In particular, knowledge of the effects of arsenic exposure in individuals who are undergoing a carcinogenesis process is lacking. Read More

View Article
July 2018
6 Reads
1.230 Impact Factor

Safety and antitumor activity of arsenic trioxide plus infusional 5-fluorouracil, leucovorin, and irinotecan as second-line chemotherapy for refractory metastatic colorectal cancer: A pilot study from South India.

Indian J Cancer 2017 Oct-Dec;54(4):631-633

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Background: After failing oxaliplatin-based first-line chemotherapy (CT), approximately 4%-21% of patients with metastatic colorectal cancer (mCRC) respond to irinotecan-based second-line treatment. Earlier studies have demonstrated that arsenic trioxide (ATO) can significantly resensitize resistant colon cancer to 5-fluorouracil (5-FU) by downregulating thymidylate synthase (TS). We hypothesized that a combination of ATO with infusional 5-FU, leucovorin, and irinotecan (FOLFIRI) regimen in mCRC patients refractory to first-line FOLFOX/CAPOX could further improve the outcome of second-line CT. Read More

View Article
October 2018
6 Reads

Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.

J Expo Sci Environ Epidemiol 2018 Sep 1;28(5):505-514. Epub 2018 Aug 1.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.

The prenatal period represents a critical window of susceptibility to inorganic arsenic (iAs) exposure from contaminated drinking water. Ingested iAs undergoes hepatic methylation generating mono and di-methyl arsenicals (MMAs and DMAs, respectively), a process that facilitates urinary arsenic (As) elimination. Differences in pregnant women's metabolism of As as indicated by greater proportions of MMAs and smaller proportions of  DMAs in urine are a risk factor for adverse birth outcomes. Read More

View Article
September 2018
8 Reads

Monomethylarsonous acid: Induction of DNA damage and oxidative stress in mouse natural killer cells at environmentally-relevant concentrations.

Mutat Res 2018 Aug 26;832-833:1-6. Epub 2018 May 26.

East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai, 200237, China; East China University of Science and Technology, School of Pharmacy, Department of Pharmaceutical Sciences, Shanghai, 200237, China; University of New Mexico, Department of Chemistry and Chemical Biology, Albuquerque, NM, 87131, USA. Electronic address:

The carcinogenicity of arsenic has been confirmed in many studies, but its mechanism of action is still unclear. A lymphocyte component of the innate immune system, natural killer (NK) cells are responsible for killing cancer cells. Although inorganic arsenical species are the prevalent forms of arsenic in the environment, monomethylarsonous acid (MMA) is the major arsenical species found in immune-system cells, in this 30 d drinking-water-exposure study in mice. Read More

View Article
August 2018
3 Reads
3.680 Impact Factor

Efficient multistep arsenate removal onto magnetite modified fly ash.

J Environ Manage 2018 Oct 26;224:263-276. Epub 2018 Jul 26.

Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120 Belgrade, Serbia.

The modification of the fly ash (FA) by magnetite (M) was performed to obtain FAM adsorbent with improved adsorption efficiency for arsenate removal from water. The novel low cost adsorbents are characterized by liquid nitrogen porosimetry (BET), scanning electron microscopy (SEM), X-ray diffraction (XRD), Mössbauer spectroscopy (MB) and Fourier transform infrared (FTIR) spectroscopy. The optimal conditions and key factors influencing the adsorbent synthesis are assessed using the response surface method (RSM). Read More

View Article
October 2018
9 Reads

Metal Biomonitoring and Comparative Assessment in Urine of Workers in Lead-Zinc and Steel-Iron Mining and Smelting.

Biol Trace Elem Res 2018 Jul 27. Epub 2018 Jul 27.

Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, People's Republic of China.

The exposure of heavy metals (lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), and metalloid arsenicals) and their effects on workers' health from a lead-zinc mine (145 workers) and a steel smelting plant (162 workers) was investigated. Information on subject characteristics was obtained through a questionnaire. We determined the urinary levels of Pb, Cd, Cu, Ni, and arsenicals (including inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), as were 8-hydroxydeoxyguanosine (8-OHdG) and cystatin C. Read More

View Article
July 2018
3 Reads

Approaches to Canine Heartworm Disease Treatment Among Alumni of a Single College of Veterinary Medicine.

J Am Anim Hosp Assoc 2018 Sep/Oct;54(5):246-256. Epub 2018 Jul 24.

From the Department of Small Animal Medicine and Surgery (A.C.D-J., A.E.C., G.S.R., K.E.C., I.R.) and Department of Infectious Diseases (A.R.M.), College of Veterinary Medicine, University of Georgia, Athens, Georgia; and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (M.C.).

This descriptive study was designed to ascertain the current heartworm treatment strategies employed by veterinary graduates of a single college of veterinary medicine, to assess the frequency with which each of these treatment strategies is prescribed, and to report the motivation behind the use of these treatment strategies. A survey containing a combination of multiple-choice and open-ended questions was distributed via e-mail with an online link during 2013 to graduates of the University of Georgia College of Veterinary Medicine. Demographic data and opinions regarding treatment for cases of canine heartworm disease (HWD) were obtained, and motivation for recommending different treatment strategies was assessed. Read More

View Article
November 2018

High efficiency removal of As(III) from waters using a new and friendly adsorbent based on sugarcane bagasse and corncob husk Fe-coated biochars.

Ecotoxicol Environ Saf 2018 Oct 19;162:616-624. Epub 2018 Jul 19.

Sao Paulo State University (UNESP), Institute of Science and Technology, Av. Tres de Marco, 511, Alto da Boa Vista, CEP: 18087-180, Sorocaba, SP, Brazil. Electronic address:

Water contamination of As is a big issue in many areas around the globe. Therefore, cheap and efficient techniques are essential facing traditional treatment methods. Then, biochars (BC) emerged recently as material that can be used for As removal. Read More

View Article
October 2018
11 Reads

Interaction of arsenic with gap junction protein connexin 43 alters gap junctional intercellular communication.

Biochim Biophys Acta Mol Cell Res 2018 Jul 19;1865(10):1423-1436. Epub 2018 Jul 19.

Department of Biological Sciences, Indian Institute of Science Education & Research Kolkata, Mohanpur 741246, West Bengal, India. Electronic address:

Chronic exposure to Arsenic pollution in ground water is one of the largest environmental health disasters in the world. The toxicity of trivalent Arsenicals primarily happens due to its interaction with sulfhydryl groups in proteins. Arsenic binding to the protein can change the conformation of the protein and alter its interactions with other proteins leading to tissue damage. Read More

View Article
July 2018
5 Reads

Mitigation of arsenic toxicity and accumulation in hydroponically grown rice seedlings by co-inoculation with arsenite-oxidizing and cadmium-tolerant bacteria.

Ecotoxicol Environ Saf 2018 Oct 19;162:591-602. Epub 2018 Jul 19.

Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand; Research Center for Environmental and Hazardous Substance Management, Khon Kaen University, Khon Kaen, Thailand; Salt-tolerant Rice Research Group, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Arsenic (As) contamination of rice grain is a serious problem worldwide. The objective of this study was to mitigate As toxicity and accumulation in hydroponically grown KDML105 rice seedlings using bacteria isolated from heavy metal-contaminated soils. Seven strains (KKU2500-1, -2, -3, -9, -12, -16 and -22) of 24 cadmium (Cd)-tolerant bacteria produced high levels of inorganic sulfide and thiol-rich compounds in As-supplemented media. Read More

View Article
October 2018
24 Reads

Biomethylation metabolism study of arsenite in SCC-7 cells by reversed phase ion pair high performance liquid chromatography-inductively coupled plasma-mass spectrometry.

Talanta 2018 Oct 25;188:210-217. Epub 2018 May 25.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China. Electronic address:

Arsenite (As(III)) has been considered as a human carcinogen associated with many human cancers especially skin cancer. Elucidation of the transformed species of As(III) during its metabolism in cells is beneficial for evaluation of its bioeffect. In this work, a hyphenated method of reversed phase ion pair high performance liquid chromatography - inductively coupled plasma mass spectrometry (RP-IP-HPLC-ICP-MS) equipped with collision/reaction cell technology (CCT) was developed for speciation of As(III) and its metabolites (arsenate [As(V)], monomethylarsonic acid [MMA(V)], and dimethylarsinic acid [DMA(V)]) in SCC-7 cells. Read More

View Article
October 2018
2 Reads

Homoarsenocholine - A novel arsenic compound detected for the first time in nature.

Talanta 2018 Oct 22;188:107-110. Epub 2018 May 22.

Institute of Chemistry, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria. Electronic address:

The arsenic speciation was determined in macrofungi of the Ramaria genus with HPLC coupled to inductively coupled plasma mass spectrometry. Besides arsenic species that are already known for macrofungi, like arsenobetaine or arsenocholine, two compounds that were only known from marine samples so far (trimethylarsoniopropanate and dimethylarsinoylacetate) were found for the first time in a terrestrial sample. An unknown arsenical was isolated and identified as homoarsenocholine. Read More

View Article
October 2018
12 Reads