29,992 results match your criteria Arsenic


Arsenic exposure and young adult's mortality risk: A 13-year follow-up study in Matlab, Bangladesh.

Environ Int 2018 Dec 15;123:358-367. Epub 2018 Dec 15.

ICDDRB, 68 Shahid Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.

Background: Widespread arsenic contamination in underground water is a well-documented public health concern that threatens millions of lives worldwide. We investigated the risk of young-adult mortality due to high chronic exposure to arsenic through years of drinking arsenic contaminated water.

Methods: A prospective cohort study of 58,406 individuals was enrolled who were 4-18 years at baseline. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.006DOI Listing
December 2018

Heavy metal poisoned and regeneration of selective catalytic reduction catalysts.

J Hazard Mater 2018 Dec 7;366:492-500. Epub 2018 Dec 7.

School of Environmental Science and Engineering, North China Electric Power University, Baoding, 071003, China.

Being poison to heterogeneous catalysts, Pb and As are important metals in the study of industrial NO emission reductions. A series of VO-WO/TiO-SiO catalysts poisoned by Pb and As were prepared through wet impregnation. The regeneration effect of deionized water, acid solution, complexing agent, and alkali solution on a poisoned catalyst was evaluated through experimental and theoretical calculations. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2018.11.112DOI Listing
December 2018

Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells.

Am J Physiol Endocrinol Metab 2018 Dec 18. Epub 2018 Dec 18.

Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Japan.

In arsenic-endemic regions of the world, arsenic exposure correlates with diabetes mellitus. Multiple animal models of inorganic arsenic (iAs, As) exposure have revealed that iAs-induced glucose intolerance manifests as a result of pancreatic β-cell dysfunction. To define the mechanisms responsible for this β-cell defect, the MIN6-K8 mouse β-cell line was exposed to environmentally-relevant doses of iAs. Read More

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http://dx.doi.org/10.1152/ajpendo.00302.2018DOI Listing
December 2018

Evaluation of Possible Human Health Risk of Heavy Metals from the Consumption of Two Marine Fish Species Tenualosa ilisha and Dorosoma cepedianum.

Biol Trace Elem Res 2018 Dec 18. Epub 2018 Dec 18.

Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission, Dhaka 1000, Bangladesh.

In order to study the effects of contaminants on human health, fish is considered as a powerful model among all available species for risk-benefit assessments. Tenualosa ilisha and Dorosoma cepedianum are two fish species of great economic importance as they are found in undeveloped, developing and developed countries. Concentrations of heavy metals lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As) and mercury (Hg) were determined using validated and accredited test methods in order to assess the potential human health risk from the dietary intake of these two selected fish species. Read More

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http://dx.doi.org/10.1007/s12011-018-1616-3DOI Listing
December 2018

Foliar uptake of arsenic nanoparticles by spinach: an assessment of physiological and human health risk implications.

Environ Sci Pollut Res Int 2018 Dec 17. Epub 2018 Dec 17.

Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, Faisalabad, 38040, Pakistan.

Atmospheric contamination by heavy metal(loid)-enriched particulate matter (metal-PM) is highly topical these days because of its high persistence, toxic nature, and health risks. Globally, foliar uptake of metal(loid)s occurs for vegetables/crops grown in the vicinity of industrial or urban areas with a metal-PM-contaminated atmosphere. The current study evaluated the foliar uptake of arsenic (As), accumulation of As in different plant organs, its toxicity (in terms of ROS generation, chlorophyll degradation, and lipid peroxidation), and its defensive mechanism (antioxidant enzymes) in spinach (Spinacia oleracea) after foliar application of As in the form of nanoparticles (As-NPs). Read More

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http://dx.doi.org/10.1007/s11356-018-3867-0DOI Listing
December 2018

Calcium ion incorporated hydrous iron(III) oxide: synthesis, characterization, and property exploitation towards water remediation from arsenite and fluoride.

Environ Sci Pollut Res Int 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Calcium ion-incorporated hydrous iron(III) oxide (CIHIO) samples have been prepared aiming investigation of efficiency enhancement on arsenic and fluoride adsorption of hydrous iron(III) oxide (HIO). Characterization of the optimized product with various analytical tools confirms that CIHIO is microcrystalline and mesoporous (pore width, 26.97 Å; pore diameter, 27. Read More

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http://dx.doi.org/10.1007/s11356-018-3872-3DOI Listing
December 2018

Assessment of Trace Metals in Consumer Chickens in Bangladesh.

J Health Pollut 2018 Dec 3;8(20):181208. Epub 2018 Dec 3.

TÜV SÜD Bangladesh Private Limited, Dhaka, Bangladesh.

Background: Bangladesh is a densely populated country with a high demand for non-vegetable protein. Poultry meat is an important source of protein due to its affordability. Trace metals are persistent in the environment and are subject to bioaccumulation in the food chain. Read More

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http://dx.doi.org/10.5696/2156-9614-8.20.181208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6285673PMC
December 2018

Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity in female rats.

Hum Exp Toxicol 2018 Dec 17:960327118818246. Epub 2018 Dec 17.

2 Department of Zoology and Entomology, Faculty of Science, Helwan University, Helwan, Egypt.

The aim of this study is to investigate the protective effects of thymoquinone (TQ) and ebselen (Eb) on arsenic (As)-induced renal toxicity in female rats. Sodium arsenite was orally administrated at a dose of 20 mg/kg body weight daily for 28 days, either alone or 1 h before TQ (10 mg/kg) or Eb (5 mg/kg) administration. Renal tissue As concentration and oxidative stress markers, including lipid peroxidation (LPO), nitrite/nitrate, and glutathione (GSH) levels, were determined. Read More

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http://dx.doi.org/10.1177/0960327118818246DOI Listing
December 2018

Removal of Arsenic(III) from Aqueous Solution Using Metal Organic Framework-Graphene Oxide Nanocomposite.

Nanomaterials (Basel) 2018 Dec 16;8(12). Epub 2018 Dec 16.

Department of Civil & Environmental Engineering, P.O. Box 755900, University of Alaska Fairbanks, Fairbanks, AK 99775, USA.

MIL-53(Al)-graphene oxide (GO) nanocomposites of different GO to MIL-53(Al) mass ratios (1% to 25% GO) were synthesized and tested for removal of arsenite (As(III)), which is a well-known groundwater contaminant. The properties of MIL-53(Al)-GO nanocomposites were characterized using X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) Spectroscopy, Brunauer-Emmett-Teller (BET) surface area measurements, and Scanning Electron Microscopy (SEM). Batch experiments were performed on MIL-53(Al)-GO nanocomposites for As(III) adsorption in aqueous solutions to investigate adsorption kinetics and isotherm behavior under varying environmental conditions. Read More

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http://dx.doi.org/10.3390/nano8121062DOI Listing
December 2018

Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.

Environ Pollut 2018 Dec 5;246:311-318. Epub 2018 Dec 5.

Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain.

Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793).

Methods: Urine metal concentrations were measured using ICP-MS. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.010DOI Listing
December 2018

Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic.

Ecotoxicol Environ Saf 2018 Dec 14;170:513-520. Epub 2018 Dec 14.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Arsenic poses a profound health risk including male reproductive dysfunction upon prolonged exposure. Histone methylation is an important epigenetic driver; however, its role in arsenic- induced steroidogenic pathogenesis remains obscure. In current study, we investigated the effect of histone H3K9 tri-methylation (H3K9me3) on expression pattern of steroidogenic genes in rat testis after long-term arsenic exposure. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.035DOI Listing
December 2018

Characterising the hypertolerance potential of two indigenous bacterial strains (Bacillus flexus and Acinetobacter junii) and their efficacy in arsenic bioremediation.

J Appl Microbiol 2018 Dec 17. Epub 2018 Dec 17.

Plant Ecology and Environmental Sciences, CSIR- National Botanical Research Institute, Rana Pratap Marg, Lucknow, 226001, India.

Aims: The aims of the study were to (1) isolate and characterize arsenic tolerant bacterial strains (2) study the plant growth promoting (PGP) traits (3) explore their bioremediation potential.

Methods And Results: Indigenous arsenic hypertolerant bacterial isolates NM02 and NM03 were screened as they were capable of growing at 150 mmol l As (V) and 70 mmol l As (III). They were identified on the basis of morphological, physiological and biochemical parameter and 16sDNA sequence as Bacillus flexus and Acinetobacter junii, respectively. Read More

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http://dx.doi.org/10.1111/jam.14179DOI Listing
December 2018

Addressing technical barriers for reliable, safe removal of fluoride from drinking water using minimally processed bauxite ores.

Dev Eng 2018 ;3:175-187

Energy Technology Area, Lawrence Berkeley National Laboratory, Berkeley, 94720 CA, USA.

Throughout the developing world, over 200 million people drink groundwater containing fluoride concentrations surpassing the World Health Organization's maximum recommended contaminant level (WHO-MCL) of 1.5 mg F/L, resulting in adverse health effects ranging from mottled tooth enamel to debilitating skeletal fluorosis. Existing technologies to remove fluoride from water, such as reverse osmosis and filtration with activated alumina, are expensive and are not accessible for low-income communities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23527285173009
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http://dx.doi.org/10.1016/j.deveng.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277820PMC
January 2018
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An efficient protocol to use iron oxide nanoparticles in microfluidic paper device for arsenic detection.

MethodsX 2018 27;5:1528-1533. Epub 2018 Oct 27.

Department of Biotechnology, National Institute of Technology Raipur, Raipur, Chhattishgarh, 492010, India.

This method describes a rapid ecofriendly and affordable method for detecting arsenic in the water sample. The system designed works on the principle that involves generation of arsine due to reduction of arsenic by bare and cysteine capped iron oxide nanoparticles and its further reaction with silver nitrate present on the microfluidic paper analytical device (μPAD). Change in the color of μPAD from colorless to reddish brown is a result of reaction between arsine gas and silver nitrate, and is the detection criteria. Read More

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http://dx.doi.org/10.1016/j.mex.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279952PMC
October 2018

Adaptions of Lichen Microbiota Functioning Under Persistent Exposure to Arsenic Contamination.

Front Microbiol 2018 30;9:2959. Epub 2018 Nov 30.

Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria.

Host-associated microbiota play an important role in the health and persistence of more complex organisms. In this study, metagenomic analyses were used to reveal microbial community adaptations in three lichen samples as a response to different arsenic concentrations at the sampling sites. Elevated arsenic concentrations at a former mining site expanded the spectrum and number of relevant functions in the lichen-associated microorganisms. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283889PMC
November 2018

The Effect of Environmental Factors on Total Arsenic Accumulation in Sarcodia suiae, Rhodophyta.

Bull Environ Contam Toxicol 2018 Dec 15. Epub 2018 Dec 15.

Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan.

Little is known about the effects of environmental factors on total arsenic (TAs) accumulation in marine Rhodophyta. The effects of five environmental factors (temperature, light intensity, pH, exposure duration, and phosphate) at various As(III) concentrations were investigated in Sarcodia suiae. The highest TAs accumulations were recorded at 25°C, a luminance of 80 µmol photons m s, and a pH of 8. Read More

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http://link.springer.com/10.1007/s00128-018-2520-4
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http://dx.doi.org/10.1007/s00128-018-2520-4DOI Listing
December 2018
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Synthesis of fly ash based zeolite-reduced graphene oxide composite and its evaluation as an adsorbent for arsenic removal.

Chemosphere 2018 Dec 4;219:504-509. Epub 2018 Dec 4.

School of Engineering, Indian Institute of Technology, Mandi, 175005, Himachal Pradesh, India. Electronic address:

A zeolite-reduced graphene oxide (ZrGO) based composite was synthesized to remove arsenic from water. To make a low-cost adsorbent, zeolite was synthesized using an inexpensive waste material; fly ash, which was further used to produce the ZrGO composite. Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Raman spectra were used to characterize the morphology and surface composition of the synthesized materials. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.203DOI Listing
December 2018
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One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Environ Int 2018 Dec 12;123:292-300. Epub 2018 Dec 12.

Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Background: Exposure to inorganic arsenic (iAs) via drinking water is a serious global health threat. Various factors influence susceptibility to iAs-associated health outcomes, including differences in iAs metabolism. Previous studies have shown that obesity is associated with iAs metabolism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183207
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http://dx.doi.org/10.1016/j.envint.2018.12.004DOI Listing
December 2018
2 Reads

An overview of plant-based interventions to ameliorate arsenic toxicity.

Biomed Pharmacother 2019 Jan 5;109:838-852. Epub 2018 Nov 5.

Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed-to-be University, Thanjavur, 613 401, India. Electronic address:

The industrial and technological advancements in the world have also contributed to the rapid deterioration in the environment quality through introduction of obnoxious pollutants that threaten to destroy the subtle balance in the ecosystem. The environment contaminants cause severe adverse effects to humans, flora and fauna that are mostly irreversible. Chief among these toxicants is arsenic, a metalloid, which is considered among the most dangerous environmental toxins that leads to various diseases which affect the quality of life even when present in small quantities. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.099DOI Listing
January 2019

Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.

Biomed Pharmacother 2019 Jan 5;109:815-822. Epub 2018 Nov 5.

Department of Occupational and Environmental Health, Dalian Medical University, 9 W Lvshun South Road, Dalian 116044, PR China. Electronic address:

Arsenic was an established carcinogen and toxicant, occurring in drinking water and food. Arsenic was increasingly being blamed as a risk factor for diabetes mellitus. Recent studies have found that arsenic could induce the generation of reactive oxygen species (ROS) and mitochondria were the major targets of ROS. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.134DOI Listing
January 2019
4 Reads

Isobaric Labeling Quantitative Metaproteomics for the Study of Gut Microbiome Response to Arsenic.

J Proteome Res 2018 Dec 14. Epub 2018 Dec 14.

Quantitative metaproteomics is a relatively new research field by applying proteomics technique to study microbial proteins of microbiome, and holds the great potential to truly quantify the functional proteins actually expressed by microbes in the biological environment such as gastrointestinal tract. The significant association between arsenic exposure and gut microbiome perturbations has been reported; however, metaproteomics has not yet been applied to study arsenic induced proteome changes of microbiome. Most importantly, to our knowledge, isobaric-labeling based large-scale metaproteomics has not been reported using the advanced database search approaches such as MetaPro-IQ and matched metagenome database search strategies to provide high quantification accuracy and less missing quantification values. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00666DOI Listing
December 2018

Heavy Metal and Metalloid Pollution of Soil, Water and Foods in Bangladesh: A Critical Review.

Int J Environ Res Public Health 2018 12 11;15(12). Epub 2018 Dec 11.

Key Laboratory for Agricultural Water Resources, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China.

Bangladesh is a densely populated developing country. Both industrialization and geological sources have caused widespread heavy metal and metalloid pollution in Bangladesh, which is now posing substantial threats to the local people. In this review, we carried out one of the most exhaustive literature analyses on the current status of Bangladesh heavy metal and metalloid pollution, covering water, soil, and foods. Read More

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http://www.mdpi.com/1660-4601/15/12/2825
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http://dx.doi.org/10.3390/ijerph15122825DOI Listing
December 2018
2 Reads

Arsenic trioxide and/or copper sulfate induced apoptosis and autophagy associated with oxidative stress and perturbation of mitochondrial dynamics in the thymus of Gallus gallus.

Chemosphere 2018 Dec 4;219:227-235. Epub 2018 Dec 4.

College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China. Electronic address:

Arsenic (As) and copper (Cu) are ubiquitous environmental contaminants that are hazardous to the immune system. Our objective was to investigate the toxicity and potential mechanisms of thymus exposure to As and/or Cu. A chicken model was established by adding arsenic trioxide (AsO; 30 mg/kg), copper sulfate (CuSO; 300 mg/kg), and simultaneously both elements in the basal diet. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.188DOI Listing
December 2018

Relative miRNA and mRNA expression involved in arsenic methylation.

PLoS One 2018 13;13(12):e0209014. Epub 2018 Dec 13.

First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.

Three arsenic species in urine are measured using an atomic absorption spectrophotometer. RT-PCR is performed to detect the expression levels of AS3MT, 3 miRNAs, and 17 relative mRNAs in 43 workers producing arsenic trioxide, 36 workers who stopped exposure to arsenic for 85 days, and 24 individuals as the control group. The concentrations of urinary arsenic are very high in workers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209014PLOS
December 2018

Anti-liver cancer effect and the mechanism of arsenic sulfide in vitro and in vivo.

Cancer Chemother Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China.

Purpose: This study aimed at investigating the anti-tumor effect of arsenic sulfide (AsS) against liver cancer both in vivo and in vitro and to elucidate its underlying mechanisms.

Methods: Cell viability of the human hepatocellular carcinoma cell lines SMMC-7721, BEL-7402, HepG2 were measured by CCK-8 assay. The effects of AsS on cell proliferation and apoptosis of SMMC-7721 cells were investigated using Calcein-AM and PI staining, Hoechst 33258 staining, crystal violet staining, and JC-1 staining. Read More

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http://dx.doi.org/10.1007/s00280-018-3755-9DOI Listing
December 2018

Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.

Oncol Rep 2018 Oct 9. Epub 2018 Oct 9.

Cell Biology Laboratory, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. China.

It is generally known that glioblastoma is the most common primary malignant brain tumor and that it is highly aggressive and deadly. Although surgical and pharmacological therapies have made long‑term progress, glioblastoma remains extremely lethal and has an uncommonly low survival rate. Therefore, further elucidation of the molecular mechanisms of glioblastoma initiation and its pathological processes are urgent. Read More

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http://dx.doi.org/10.3892/or.2018.6777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196630PMC
October 2018
2.191 Impact Factor

Association between lung cancer risk and inorganic arsenic concentration in drinking water: a dose-response meta-analysis.

Toxicol Res (Camb) 2018 Nov 18;7(6):1257-1266. Epub 2018 Sep 18.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease , School of Public Health , Soochow University , Suzhou , 215123 , PR China.

High dose arsenic in drinking water (≥100 μg L) is known to induce lung cancer, but lung cancer risks at low to moderate arsenic levels and its dose-response relationship remains inconclusive. We conducted a systematic review of cohort and case-control studies that quantitatively reported the association between arsenic concentrations in drinking water and lung cancer risks by searching the PubMed database till June 14, 2018. Pooled relative risks (RRs) of lung cancer associated with full range (10 μg L-1000 μg L) and low to moderate range (<100 μg L) of water arsenic concentrations were calculated using random-effects models. Read More

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http://dx.doi.org/10.1039/c8tx00177dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249628PMC
November 2018

Groundwater Irrigation and Arsenic Speciation in Rice in Cambodia.

J Health Pollut 2018 Sep 10;8(19):180911. Epub 2018 Sep 10.

University of Ottawa, Canada.

Background: Arsenic bioaccumulation in rice is a global concern affecting food security and public health.

Objective: The present study examined arsenic species in rice in Cambodia to characterize health risks with rice consumption and to clarify uncertainties with Codex guidelines.

Methods: The present study collected 61 well water samples, 105 rice samples, 70 soil samples, and conducted interviews with 44 families in Preak Russey near the Bassac River and Kandal Province along the Mekong River in Cambodia. Read More

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http://dx.doi.org/10.5696/2156-9614-8.19.180911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257176PMC
September 2018

Effects of Arsenic, Iron and Fertilizers in Soil on Rice in Cambodia.

J Health Pollut 2018 Sep 10;8(19):180910. Epub 2018 Sep 10.

University of Ottawa, Canada.

Background: In parts of Cambodia, irrigation with groundwater results in arsenic accumulation in soils and rice, leading to health concerns associated with rice consumption. A high concentration of iron in groundwater can precipitate arsenic and reduce its bioavailability, however high concentrations of arsenic and iron can also reduce rice production. Furthermore, concerns have been raised about chemical contamination from inorganic fertilizers used to grow rice. Read More

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http://www.journalhealthpollution.org/doi/10.5696/2156-9614-
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http://dx.doi.org/10.5696/2156-9614-8.19.180910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257173PMC
September 2018
1 Read

Concentrations and Human Health Risk of Heavy Metals in Rivers in Southwest Nigeria.

J Health Pollut 2018 Sep 10;8(19):180907. Epub 2018 Sep 10.

Department of Industrial Chemistry, The Technical University, Ibadan, Oyo State, Nigeria.

Background: Rivers are the most vital freshwater resources in the world. In Southwest Nigeria, anthropogenic activity stresses the quantity and quality of water resources.

Methods: The present study examined the concentrations and human health risk of five heavy metals (manganese (Mn), arsenic (As), chromium (Cr), cadmium (Cd), and lead (Pb)) in selected rivers in Southwest Nigeria. Read More

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http://www.journalhealthpollution.org/doi/10.5696/2156-9614-
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http://dx.doi.org/10.5696/2156-9614-8.19.180907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257163PMC
September 2018
5 Reads

Characterization, Spatial Variation and Risk Assessment of Heavy Metals and a Metalloid in Surface Soils in Obuasi, Ghana.

J Health Pollut 2018 Sep 20;8(19):180902. Epub 2018 Aug 20.

Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060-0818, Japan.

Background: Soil contamination with heavy metals and metalloids has become an increasingly important issue in recent years.

Objectives: The present study examines possible contamination of the environment with metals from gold mining activities in Obuasi, Ghana.

Methods: Soil samples were collected from commercial and residential areas and tailing dams in Obuasi in order to investigate the extent of lead (Pb), cadmium (Cd), mercury (Hg), copper (Cu), zinc (Zn), cobalt (Co), chromium (Cr), nickel (Ni) and arsenic (As) pollution, create thematic maps showing the extent of heavy metals pollution, identify the sources of pollution, and to assess risks to humans and the surrounding ecological system. Read More

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http://dx.doi.org/10.5696/2156-9614-8.19.180902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257175PMC
September 2018

Heavy Metal Pollution Near a Tannery in Ulaanbaatar, Mongolia.

J Health Pollut 2017 Dec 18;7(16):2-11. Epub 2017 Dec 18.

Environment and Security Center of Mongolia, Ulaanbaatar, Mongolia.

Background: Due to an increase in population density and industrialization, the capital city of Mongolia, Ulaanbaatar, has been experiencing an increase in environmental pollution; especially soil contamination. Environmental pollutants include solid waste, silt and wastewater coming out of tanneries in three micro districts of the Khan-Uul district of Ulaanbaatar. Among the many types of chemicals these tanneries use, chromium (III) sulfate (Cr(SO)) poses the most serious environmental health risk. Read More

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http://dx.doi.org/10.5696/2156-9614-7.16.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221445PMC
December 2017

Chemical fractionation of heavy metals in fine particulate matter and their health risk assessment through inhalation exposure pathway.

Environ Geochem Health 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemistry, Dayalbagh Educational Institute, Agra, U.P., 282005, India.

Samples of PM were collected from an urban area close to a national highway in Agra, India and sequentially extracted into four different fractions: water soluble (F1), reducible (F2), oxidizable (F3) and residual fraction (F4) for chemical fractionation of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), nickel (Ni) and lead (Pb). The metals were analyzed by inductively coupled plasma optical emission spectroscopy in each fraction. The average mass concentration of PM was 93 ± 24 μg m. Read More

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http://link.springer.com/10.1007/s10653-018-0223-8
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http://dx.doi.org/10.1007/s10653-018-0223-8DOI Listing
December 2018
6 Reads

Speciation Analysis of Arsenic Compounds by HPLC-ICP-MS: Application for Human Serum and Urine.

J Anal Methods Chem 2018 13;2018:9462019. Epub 2018 Nov 13.

School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hai Ba Trung, Hanoi 100000, Vietnam.

A high-performance liquid chromatography (HPLC) in combination with inductively coupled plasma mass spectrometry (ICP-MS) as an elemental specific detector was used for the speciation analysis of arsenic compounds in urine and serum samples from Vietnam. Five arsenic species including arsenite (As), arsenate (As), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB) were studied. A gradient elution of ammonium carbonate ((NH)CO), ethylenediaminetetraacetic acid disodium salt (NaEDTA), and methanol at pH 9. Read More

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http://dx.doi.org/10.1155/2018/9462019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258103PMC
November 2018

The return of gemtuzumab ozogamicin: a humanized anti-CD33 monoclonal antibody-drug conjugate for the treatment of newly diagnosed acute myeloid leukemia.

Onco Targets Ther 2018 22;11:8265-8272. Epub 2018 Nov 22.

Division of Hematology and Oncology, Rhode Island Hospital, The Alpert Medical School of Brown University, Providence, RI, USA,

Through the years gemtuzumab ozogamicin (GO) has moved from a panacea in the treatment of acute myeloid leukemia (AML) to a pariah and back again. Early promise of targeted therapy with accelerated approval in the United States in 2000 gave way to fear over increased toxicity in the absence of efficacy, which subsequently resulted in the drug manufacturer voluntarily withdrawing GO from the market in 2010. We outline the history of GO in terms of initial drug development and early clinical trials that ultimately led the way to GO frontline use in AML based on a series of Phase III studies. Read More

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http://dx.doi.org/10.2147/OTT.S150807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254990PMC
November 2018

Design of Gravel-Sand Filter for Arsenic Removal: A Case Study of Muzaffargarh District in Pakistan.

Water Environ Res 2018 Dec;90(12):2106-2113

Arsenic decontamination of drinking water has grabbed significant attention due to arsenic's serious effects on health. A novel gravel-sand filter (GSF) holding zero-valent iron plates was designed and constructed in Muzaffargarh district (Pakistan) for arsenic removal from drinking water with lower iron concentration (0.3 ppm). Read More

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http://dx.doi.org/10.2175/106143017X15131012188240DOI Listing
December 2018

Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia.

Sci Total Environ 2018 Dec 2;657:179-186. Epub 2018 Dec 2.

Hydrosciences Montpellier, Institut de Recherche pour le Développement, CNRS, University of Montpellier, France.

Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.473DOI Listing
December 2018

[Directed acyclic graphs in statistical modelling of epidemiological studies].

Rev Med Chil 2018 Jul;146(7):907-913

Programa de Salud Ambiental, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile.

Background: Confusion in observational epidemiological studies distorts the relationship between exposure and event. "Step by step" regression models, diverts the decision to a statistical algorithm with little causal basis. Directed Acyclic Graphs (DAGs), qualitatively and visually assess the confusion. Read More

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http://dx.doi.org/10.4067/s0034-98872018000700907DOI Listing

Draft Genome Sequence of Pseudarthrobacter sp. Strain AG30, Isolated from a Gold and Copper Mine in China.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

Institute of Environmental Microbiology, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou, China.

Here, we report the features and draft genome sequence of Pseudarthrobacter sp. strain AG30, isolated from the Zijin gold and copper mine in China. The genome size of Pseudarthrobacter sp. Read More

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http://dx.doi.org/10.1128/MRA.01329-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256500PMC
November 2018

AsChip: a high-throughput qPCR chip for comprehensive profiling of genes linked to microbial cycling of arsenic.

Environ Sci Technol 2018 Dec 11. Epub 2018 Dec 11.

Arsenic (As) is a ubiquitous toxic element adversely affecting human health. Microbe-mediated cycling of As is largely mediated by detoxification and energy metabolism in microorganisms. We here report the development of a novel high-throughput qPCR (HT-qPCR) chip (AsChip) for comprehensive profiling of genes involved in As microbial As cycling (As genes). Read More

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http://dx.doi.org/10.1021/acs.est.8b03798DOI Listing
December 2018

Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells.

Drug Des Devel Ther 2018 14;12:3913-3927. Epub 2018 Nov 14.

Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China,

Purpose: Gastric and colon cancers have been the leading causes of cancer mortality in the world with limited therapy. Small molecules binding to bromodomains of bromodomain-containing protein 4 (BRD4) exert strong antitumor activities against hematological malignancies, while generally have limited efficacy in advanced solid tumors. Here, we found that the bromodomain and extra-terminal (BET)-bromodomain inhibitor JQ1, when combined with arsenic sulfide (AsS, abbreviated as AS), synergistically decreased the expression of nuclear factor of activated T-cells (NFATs) as well as the downstream oncogene c-Myc and largely induced cell apoptosis via mitochondrial pathway in gastric and colon cancer cell lines. Read More

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http://dx.doi.org/10.2147/DDDT.S180976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241694PMC
November 2018

A field-pilot for passive bioremediation of As-rich acid mine drainage.

J Environ Manage 2018 Dec 6;232:910-918. Epub 2018 Dec 6.

HydroSciences Montpellier, Univ. Montpellier, CNRS, IRD, CC57, 163 Rue Auguste Broussonnet, 34090, Montpellier, France.

A field-pilot bioreactor exploiting microbial iron (Fe) oxidation and subsequent arsenic (As) and Fe co-precipitation was monitored during 6 months for the passive treatment of As-rich acid mine drainage (AMD). It was implemented at the Carnoulès mining site (southern France) where AMD contained 790-1315 mg L Fe(II) and 84-152 mg L As, mainly as As(III) (78-83%). The bioreactor consisted in five shallow trays of 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797183138
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http://dx.doi.org/10.1016/j.jenvman.2018.11.116DOI Listing
December 2018
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Long-term leaching of arsenic from pressure-treated playground structures in the northeastern United States.

Sci Total Environ 2018 Nov 22;656:834-842. Epub 2018 Nov 22.

Department of Environmental Health Sciences, School of Public Health, Yale University, New Haven, CT 06520, USA.

Wood used in playground structures built prior to 2004 was pressure-treated with chromated copper arsenate (CCA) which has been associated with negative health and environmental impacts. Given the prevalence and lack of maintenance of these aging play structures in rural northeastern US, the aim of this study was to determine the distribution of As (total, speciated and bioaccessible) in surface soil collected near and underneath four CCA-treated playground structures 16- and 26-years following installation. Note that one playground in southeastern MA was studied where surface soil samples were collected at various distances from the structures (0, 5, 15, and 30 cm). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.315DOI Listing
November 2018

Immobilized bacterial biosensor for rapid and effective monitoring of acute toxicity in water.

Ecotoxicol Environ Saf 2018 Dec 6;170:205-209. Epub 2018 Dec 6.

Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto 53123, Indonesia.

The use of biosensors by using microorganisms such as bacteria have short life cycles and provide other advantages. One colorimetric biosensor technique that has been developed is the use of a biosensor utilizing the incorporation of Prussian blue formation reactions mediated by E. coli bioreactors with ferricyanide. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.141DOI Listing
December 2018

Assessment of potentially toxic trace element contamination in urban allotment soils and their uptake by onions: A preliminary case study from Sheffield, England.

Ecotoxicol Environ Saf 2018 Dec 5;170:156-165. Epub 2018 Dec 5.

Department of Geography, The University of Sheffield, Sheffield S10 2TN, United Kingdom.

Toxic trace element (TTE) contamination in urban soils may pose potential health risks, especially in cities with previous industrial activities. This study aimed to investigate soil contamination in urban allotments in Sheffield, the uptake of TTEs in autumn and spring sown onions (Allium cepa), and their potential risks on human health via consumption of the crops. Paired soil and plant samples were taken in triplicates from four private allotments to assess potentially elevated levels of lead (Pb), zinc (Zn), copper (Cu), arsenic (As), and chromium (Cr). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.11.090DOI Listing
December 2018
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Effect of low salinity on acute arsenic toxicity and bioconcentration in shrimp Litopenaeus vannamei juveniles.

Comp Biochem Physiol C Toxicol Pharmacol 2018 Dec 4;218:1-7. Epub 2018 Dec 4.

Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Unidad Académica Mazatlán, Joel Montes Camarena s/n, Mazatlán 82040, Sinaloa, Mexico; El Colegio de Sinaloa, Centro, Culiacán, Sinaloa, Mexico. Electronic address:

This study investigated acute arsenic toxicity and bioconcentration capacity in Litopenaeus vannamei because it has been frequently exposed to lower salinities than its isosmotic point (25 g L). Juveniles (9.9 ± 0. Read More

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http://dx.doi.org/10.1016/j.cbpc.2018.12.005DOI Listing
December 2018

An improved and simple method for removal of arsenic from drinking water.

J Environ Sci (China) 2019 Feb;76:415-417

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2G3, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10010742183343
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http://dx.doi.org/10.1016/j.jes.2018.11.017DOI Listing
February 2019
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Modified activated carbon with interconnected fibrils of iron-oxyhydroxides using Mn as morphology regulator, for a superior arsenic removal from water.

J Environ Sci (China) 2019 Feb 14;76:403-414. Epub 2018 Jun 14.

Environmental Sciences Division, Potosino Institute of Scientific and Technological Research, IPICyT, Camino a la Presa San Jose 2055, Lomas 4, ZIP 78216, San Luis Potosi, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.jes.2018.06.002DOI Listing
February 2019

Evaluation of natural goethite on the removal of arsenate and selenite from water.

J Environ Sci (China) 2019 Feb 30;76:133-141. Epub 2018 Apr 30.

Department of Chemical Engineering, University of Wyoming, Laramie, WY 82071, USA. Electronic address:

Elevated arsenic and selenium concentrations in water cause health problems to both humans and wildlife. Natural and anthropogenic activities have caused contamination of these elements in waters worldwide, making the development of efficient cost-effective methods in their removal essential. In this work, removal of arsenate and selenite from water by adsorption onto a natural goethite (α-FeOOH) sample was studied at varying conditions. Read More

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http://dx.doi.org/10.1016/j.jes.2018.04.016DOI Listing
February 2019

Myelodysplastic syndromes and acute myeloid leukemias in the elderly.

Eur J Intern Med 2018 12;58:28-32

Department of Medical Oncology, Inselspital, University Hospital and University of Bern, Bern, Switzerland. Electronic address:

Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy for patients up to 80 years, with the exception of patients with unfavorable genomic risk abnormalities or with major co-morbidities. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.05.026DOI Listing
December 2018