249,422 results match your criteria Arrhythmia & electrophysiology review[Journal]


Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats.

Auton Neurosci 2020 Jun 24;227:102695. Epub 2020 Jun 24.

Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102695DOI Listing

Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression.

Life Sci 2020 Jul 3:118047. Epub 2020 Jul 3.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address:

Aim: The purpose of the study was to investigate what effects the sigma-1 receptor (S1R) could exert on the cardiac myocyte ion channels in a rodent model of depression and to explore the underlying mechanisms since depression is an independent risk factor for cardiovascular diseases including ventricular arrhythmias (VAs).

Materials And Methods: To establish the depression model in rats, chronic mild unpredictable stress (CMUS) for 28 days was used. The S1R agonist fluvoxamine was injected intraperitoneally from the second week to the last week for 21 days in total, and the effects were evaluated by patch clamp, western blot analysis, and Masson staining. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118047DOI Listing

Spiked Helmet Sign.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiology, Cardiac Arrhythmia Service, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.05.043DOI Listing

Artificial Intelligence and Machine Learning in Arrhythmias and Cardiac Electrophysiology.

Circ Arrhythm Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiovascular Medicine, Stanford University, Stanford & Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.

Artificial intelligence (AI) and machine learning (ML) in medicine are currently areas of intense exploration, showing potential to automate human tasks and even perform tasks beyond human capabilities. Literacy and understanding of AI/ML methods are becoming increasingly important to researchers and clinicians. The first objective of this review is to provide the novice reader with literacy of AI/ML methods and provide a foundation for how one might conduct an ML study. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.007952DOI Listing

Frailty in patients with mild autonomous cortisol secretion is higher than in patients with nonfunctioning adrenal tumors.

J Clin Endocrinol Metab 2020 Jul 6. Epub 2020 Jul 6.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN.

Context: Mild autonomous cortisol secretion (MACS) affects up to 50% of patients with adrenal adenomas. Frailty is a syndrome characterized by the loss of physiological reserves and an increase in vulnerability, and serves as a marker of declining health.

Objective: To compare frailty in patients with MACS versus nonfunctioning adrenal tumors (NFAT). Read More

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http://dx.doi.org/10.1210/clinem/dgaa410DOI Listing

In Children and Adolescents From Brugada Syndrome-Families, Only Mutation Carriers Develop a Type-1 ECG Pattern Induced By Fever.

Circulation 2020 Jul 6;142(1):89-91. Epub 2020 Jul 6.

Department of Pediatric Cardiology, Emma Children's Hospital (P.J.P, N.A.B., A.S.V., S.-A.B.C.), Amsterdam University Medical Center, location Academic Medical Center (AMC), The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.045720DOI Listing

Standard procedures in nonoperating room anesthesia.

Curr Opin Anaesthesiol 2020 Aug;33(4):539-547

Department of Anesthesiology, Nonoperating Room Anesthesia, Yale University School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: This article provides an overview of standard procedures currently performed in nonoperating room anesthesia (NORA) and highlights anesthetic implications.

Recent Findings: Novel noninvasive interventional procedures remain on the rise, accelerating demand for anesthesia support outside the conventional operating room. The field of interventional oncology has introduced a variety of effective minimally invasive therapies making interventional radiology gain a major role in the management of cancer. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000898DOI Listing

Cardiac tamponade: an educational review.

Eur Heart J Acute Cardiovasc Care 2020 Jul 6:2048872620939341. Epub 2020 Jul 6.

University Cardiology, AOU Città della Salute e della Scienza di Torino, Italy.

Cardiac tamponade is a pericardial syndrome characterised by an impairment of the diastolic filling of the ventricles causing reduction of cardiac output, usually producing signs and symptoms of cardiac arrest, if untreated. The main causes of cardiac tamponade include percutaneous cardiac interventions, malignacies, infectious/inflammatory causes, mechanical complications of myocardial infarction and aortic dissection. The diagnosis of cardiac tamponade is a clinical diagnosis based on a suggestive history and clinical presentation with worsening dyspnoea, distended jugular veins, muffled heart sounds and pulsus paradoxus, and should be confirmed by echocardiography. Read More

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http://dx.doi.org/10.1177/2048872620939341DOI Listing

Multi-method assessment of palatable food exposure in women with and without eating disorders.

Eur Eat Disord Rev 2020 Jul 6. Epub 2020 Jul 6.

TEDp (Temple Eating Disorders Program), Temple University, 1701 North 13th Street, Philadelphia, Pennsylvania, 19122, USA.

Objective: Eating disorders (EDs) are characterized by dysregulated responses to palatable food. Using a multi-method approach, this study examined responses to palatable food exposure and subsequent ad libitum eating in women with binge-eating disorder (BED: n = 64), anorexia nervosa (AN: n = 16), and bulimia nervosa (BN: n = 35) and 26 healthy controls (HCs).

Method: Participants were exposed to palatable food followed by an ad libitum eating opportunity. Read More

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http://dx.doi.org/10.1002/erv.2746DOI Listing

The inaugural meeting of the Africa Heart Rhythm Association (AFHRA).

Cardiovasc J Afr 2020 May/Jun;31(3):162-164

West Yorkshire Arrhythmia Service, Leeds General Infirmary, Leeds, UK.

Cardiorhythm Africa, the inaugural conference of AFHRA, was conceived during the biennial PASCAR congress held in Johannesburg in November 2019, with the ambition to be the largest ever pan-African conference focused purely on arrhythmia. Significant aims were to (1) bring together arrhythmia specialists from across Africa and from the diaspora; and (2) announce the newly formed African Heart Rhythm Association (AFHRA), an affiliate organisation of PASCAR formed from the amalgamation of the Cardiac Pacing and Arrhythmias taskforces. The meeting held in Nairobi (29-31 January 2020) was organised to provide a focus on resource-constrained arrhythmia management within the African context and novel/advanced and potentially home-grown solutions. Read More

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http://dx.doi.org/10.5830/CVJA-2020-019DOI Listing

Risk factors for agitation and hyperactive delirium in adult postcardiotomy patients with extracorporeal membrane oxygenation support: an observational study.

Perfusion 2020 Jul 4:267659120937549. Epub 2020 Jul 4.

Center for Cardiac Intensive Care, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Agitation and delirium in critically ill patients after cardiac surgery carry poor in-hospital prognosis. Identifying risk factors may promote its prevention and management. Accordingly, this study aimed to evaluate the incidence of agitation and hyperactive delirium in postcardiotomy patients during the extracorporeal membrane oxygenation support and to identify the risk factors for its development. Read More

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http://dx.doi.org/10.1177/0267659120937549DOI Listing

Impact of Left Common Pulmonary Veins in the Contact-Force vs. Cryoballoon Atrial Fibrillation Ablation (CIRCA-DOSE) Study.

J Cardiovasc Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

Heart Rhythm Services, Department of Medicine, University of British Columbia, Canada.

Background: Concerns remain regarding the effectiveness of PVI using the fixed diameter non-compliant cryoballoon in the presence of a left common pulmonary vein (LCPV). We sought to evaluate the effectiveness of PVI performed by contact-force guided radiofrequency (CF-RF) versus second-generation cryoballoon-based ablation in patients with LCPV.

Methods And Results: We enrolled 346 patients with paroxysmal AF and randomized them to CF-RF or cryoballoon ablation. Read More

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http://dx.doi.org/10.1111/jce.14652DOI Listing

Implantable cardiac defibrillator leads dysfunction after LVAD implantation.

Pacing Clin Electrophysiol 2020 Jul 5. Epub 2020 Jul 5.

Univ Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, Rennes, F-35000, France.

Background: Implantable cardioverter-defibrillator (ICD) lead dysfunction have been reported after left ventricular assist device (LVAD) implantation in limited single-center studies. We aimed to describe and characterize the incidence of ICD lead parameters dysfunction after LVAD implantation.

Methods: Among the 652 patients enrolled in the ASSIST-ICD study, only patients with an ICD prior to LVAD were included (n = 401). Read More

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http://dx.doi.org/10.1111/pace.14004DOI Listing

The impact of oral nicorandil pre-treatment on ST resolution and clinical outcome of patients with acute ST-segment elevation myocardial infarction undergoing primary coronary angioplasty: A randomized placebo controlled trial.

J Cardiovasc Thorac Res 2020 8;12(2):90-96. Epub 2020 May 8.

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Literature has shown the effects of intravenous/intracoronary nicorandil on increased myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) treated with mechanical reperfusion. However, the possible cardioprotective effect of oral nicorandil on the clinical outcome prior to primary coronary angioplasty is not well documented. Our aim was to assess the effect of oral nicorandil on primary percutaneous coronary intervention (PPCI). Read More

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http://dx.doi.org/10.34172/jcvtr.2020.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321000PMC

Reference values for a novel ambulatory-based frequency domain T-wave alternans in subjects without structural heart disease.

J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, Japan.

Background: Conventional frequency domain T wave alternans (FD-TWA) is a noninvasive risk stratification marker for identifying arrhythmic sudden cardiac death, but the conventional FD-TWA device that was considered the gold standard device has been discontinued commercially. Recently, a newly developed ambulatory electrocardiogram (AECG) device that can detect FD-TWA continuously for 24 h has become available in clinical settings. However, information on the normal values using the novel AECG-based frequency domain TWA (FD-TWA) is lacking. Read More

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http://dx.doi.org/10.1016/j.jjcc.2020.06.002DOI Listing

A Teenager with Congenital Heart Defect and Covid-19.

Cardiol Young 2020 Jul 6:1-5. Epub 2020 Jul 6.

Kinderkardiologie/Herzchirurgie für angeborene Herzfehler, Universitäres Herz- und Gefäßzentrum UKE Hamburg, Universitätsklinikum Hamburg Eppendorf.

A 16 year-old girl with history of treated congenital mitral valve disease and signs of respiratory infection was admitted to our pediatric cardiology department. She was tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite her severe preexisting cardiac conditions with pulmonary hypertension, atrial arrhythmias and mitral valve stenosis, the infection did not lead to any cardiac or pulmonary deterioration. Read More

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http://dx.doi.org/10.1017/S1047951120002127DOI Listing

Relationship With Calcium, Nutritional Risk, QTc Interval, Tp-e Interval and Tp-e/QTc Ratio of Critical Care Patients.

JPEN J Parenter Enteral Nutr 2020 Jul 5. Epub 2020 Jul 5.

Department of General Surgery, Health Science University, Adana City Research and Training Hospital, Adana, Turkey.

Background: To the best of our knowledge, there are studies related to QTc interval in critical care patients whose nutritional scores are evaluated, but there are no studies evaluating T wave peak and end interval (Tp-e interval), Tp-e/QT and Tp-e/QTc ratios used to evaluate cardiac arrhythmia risk and ventricular repolarization changes rates. Therefore, we aimed to investigate whether there is a change in Tp-e interval, Tp-e/QT and Tp-e/QTc ratios in patients whose nutritional scores are evaluated.

Methods: This study was planned as a retrospective cross-sectional study. Read More

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http://dx.doi.org/10.1002/jpen.1955DOI Listing

Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle.

Auton Neurosci 2020 Jun 26;227:102696. Epub 2020 Jun 26.

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Background: Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102696DOI Listing

The association between regular cocaine use, with and without tobacco co-use, and adverse cardiovascular and respiratory outcomes.

Drug Alcohol Depend 2020 Jun 27;214:108136. Epub 2020 Jun 27.

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, 3131 Harvey Avenue, Cincinnati, OH 45229, USA; Center for Addiction Research, University of Cincinnati College of Medicine, 3131 Harvey Avenue, Cincinnati, OH 45229, USA.

Background: Understanding the potential impact of cocaine use on health is increasingly important as cocaine use rises in the U.S.

Objectives: This study evaluated the associations of regular cocaine use, with and without tobacco co-use, with cardiovascular and respiratory outcomes. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108136DOI Listing

Prophylactic (hydroxy)chloroquine in COVID-19: potential relevance for cardiac arrhythmia risk.

Heart Rhythm 2020 Jul 2. Epub 2020 Jul 2.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands; European Cardiac Arrhythmia Genetics Focus Group (ECGen) of the European Heart Rhythm Association (EHRA). Electronic address:

(Hydroxy)chloroquine ((H)CQ) is being investigated as treatment for COVID-19, but studies have so far demonstrated either no or a small benefit. However, these studies have been mostly performed in patients admitted to hospital and hence likely already (severely) affected. Another suggested approach employs prophylactic (H)CQ treatment aimed at preventing either SARS-CoV-2 infection or development of disease. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.07.001DOI Listing

Cantú syndrome versus Zimmermann-Laband syndrome: Report of nine individuals with ABCC9 variants.

Eur J Med Genet 2020 Jul 2:103996. Epub 2020 Jul 2.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Cantú syndrome (CS) is a rare developmental disorder characterized by a coarse facial appearance, macrocephaly, hypertrichosis, skeletal and cardiovascular anomalies and caused by heterozygous gain-of-function variants in ABCC9 and KCNJ8, encoding heterooctameric ATP-sensitive potassium (K) channels. CS shows considerable clinical overlap with Zimmermann-Laband syndrome (ZLS), a rare condition with coarse facial features, hypertrichosis, gingival overgrowth, intellectual disability of variable degree, and hypoplasia or aplasia of terminal phalanges and/or nails. ZLS is caused by heterozygous gain-of-function variants in KCNH1 or KCNN3, and gain-of-function KCNK4 variants underlie the clinically similar FHEIG (facial dysmorphism, hypertrichosis, epilepsy, intellectual disability/developmental delay, and gingival overgrowth) syndrome; KCNH1, KCNN3 and KCNK4 encode potassium channels. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103996DOI Listing

Adults with Congenital Heart Disease and Arrhythmia Management.

Cardiol Clin 2020 Aug 7;38(3):417-434. Epub 2020 Jun 7.

Electrophysiology Service and Adult Congenital Heart Disease Center; Department of Medicine, Montreal Heart Institute, Université de Montréal, 5000 Bélanger Street, Montreal, Quebec H1T 1C8, Canada.

Arrhythmia management in adult congenital heart disease (ACHD) encompasses a wide range of problems from bradyarrhythmia to tachyarrhythmia, sudden death, and heart failure-related electrical dyssynchrony. Major advances in the understanding of the pathophysiology and treatments of these problems over the past decade have resulted in improved therapeutic strategies and outcomes. This article attempts to define these problems and review contemporary management for the patient with ACHD presenting with cardiac arrhythmia. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.006DOI Listing

The Adult Patient with a Fontan.

Cardiol Clin 2020 Aug;38(3):379-401

Adult Congenital Heart Disease, Heart Centre, King Faisal Specialist Hospital and Research Centre, Zahrawi Street, Al Maather, Al Maazer, Riyadh 12713, Saudi Arabia. Electronic address:

The authors summarize the most important anatomic and physiologic substrates of Fontan circulation. Common anatomic substrates include hypoplastic left heart syndrome, tricuspid atresia, double inlet left ventricle, and unbalanced atrioventricular septal defects. After the Fontan operation exercise capacity is limited and the key hemodynamic drivers is limited preload due to a relatively fixed pulmonary vascular resistance. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.05.002DOI Listing

Atrial Septal Defect.

Cardiol Clin 2020 Aug 6;38(3):317-324. Epub 2020 Jun 6.

Mount Sinai Cardiovascular Institute, The Children's Heart Center, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, 1190 5th Avenue, Box 1030, New York, NY 10029, USA. Electronic address: https://twitter.com/AliZaidi%20MD.

Atrial septal defects are common congenital heart defects, characterized by insufficient/absent tissue at the interatrial septum. An unrepaired defect may be associated with right heart volume overload, atrial arrhythmia or pulmonary arterial hypertension. The 3 major types of atrial septal defect are: ostium secundum defect, ostium primum defect, and sinus venosus. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.001DOI Listing

Metformin Preferentially Provides Neuroprotection Following Cardiac Ischemia/Reperfusion in Non-Diabetic Rats.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 1:165893. Epub 2020 Jul 1.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Following acute myocardial infarction, re-establishment of coronary perfusion aggravates further injuries in the heart and remote organs including the brain as a consequence of ischemia/reperfusion (I/R) injury. Since pretreatment with metformin attenuated both cardiac and cerebral I/R injury via AMP-activated protein kinase (AMPK) pathways, we hypothesized that metformin given after ischemia mitigates both cardiac and brain pathologies following cardiac I/R. Male Wistar rats were subjected to either cardiac I/R (30 min-ischemia/120 min-reperfusion; n=30) or sham operation (n=5). Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165893DOI Listing

INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).

Heart Rhythm 2020 Jul 1. Epub 2020 Jul 1.

Section of Pediatric Cardiology; Departments of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University.

Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially pro-arrhythmic Hydroxychloroquine (HCQ) and Azithromycin (AZN).

Objectives: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment.

Methods: A single center retrospective chart review was undertaken and included all patients with 1) symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328618PMC

Resting High Frequency Heart Rate Variability and PTSD Symptomatology in Veterans: Effects of Respiration, Role in Elevated Heart Rate, and Extension to Spouses.

Biol Psychol 2020 Jul 1:107928. Epub 2020 Jul 1.

University of Utah, United States.

Heart rate variability (HRV) associated with parasympathetic activity (i.e., cardiac vagal tone) is reduced in posttraumatic stress disorder (PTSD), but possible confounding effects of respiration have not been studied sufficiently. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2020.107928DOI Listing

[A crosscorrelation analysis of fluctuations in heart rate and breathing when diagnosing the autonomic disorders in patients with hypotonic type of functional dysphonia].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):60-66

Research Center of Neurology, Moscow, Russia.

Objective: To conduct a cross-correlation analysis of the frequency of breathing and heart rhythm variability (HRV) in the diagnosis of autonomic disorders in patients with hypotonic type of functional dysphonia.

Material And Methods: Twenty-eight women, aged between 21 and 63 years, with hypotonic type of functional dysphonia were examined. The examination of patients included an analysis of anamnesis, an objective ENT study by common methods, videostroboscopy of the larynx, and determination of the functional state of the autonomic nervous system (ANS). Read More

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http://dx.doi.org/10.17116/jnevro202012005160DOI Listing
January 2020

Value of Defibrillation Threshold Testing in Children with Non-Transvenous Implantable Cardioverter Defibrillators - Are routine DFT tests indicated?

Pacing Clin Electrophysiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Cardiology and Intensive Care Medicine, Georg August University Medical Center, Göttingen, Germany.

Background: Non-transvenous implanted cardioverter defibrillators (NT-ICD) are used in infants and small children with life-threatening ventricular tachyarrhythmias. With growth, shock vector shift may result in increase of defibrillation threshold (DFT) and fatal ICD failure.

Objectives: Up to date, the only way to verify ICD function in children with NT-ICD is repetitive DFT testing which is potentially harmful and may even be life-threatening. Read More

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http://dx.doi.org/10.1111/pace.14003DOI Listing

Characterization of troponin I levels post synchronized direct current cardioversion of atrial arrhythmias in patients with and without cardiomyopathy.

J Interv Card Electrophysiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiology, Cork University Hospital, Cork, Ireland.

Background: Cardiac-specific markers of myocardial injury, such as troponin I (TnI), are often elevated following procedures that stimulate the myocardium. This study aimed to determine the effect of synchronized direct current (DC) cardioversion of atrial arrhythmias on myocardial injury 6-h post-procedure, as measured by cardiac TnI in patients with and without cardiomyopathy.

Methods: Seventy-three individuals (59 M:14 F) participated in this study. Read More

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http://dx.doi.org/10.1007/s10840-020-00814-xDOI Listing

Cav1.2 channelopathies causing autism: new hallmarks on Timothy syndrome.

Pflugers Arch 2020 Jul 3. Epub 2020 Jul 3.

Department of Drug Science, Laboratory of Cellular and Molecular Neuroscience, N.I.S. Centre, Corso Raffaello 30, 10125, Torino, Italy.

Cav1.2 L-type calcium channels play key roles in long-term synaptic plasticity, sensory transduction, muscle contraction, and hormone release. De novo mutations in the gene encoding Cav1. Read More

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http://dx.doi.org/10.1007/s00424-020-02430-0DOI Listing

Autophagy in cardiovascular health and disease.

Prog Mol Biol Transl Sci 2020 12;172:87-106. Epub 2020 May 12.

Department of Cardiology, Medical University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria; Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia. Electronic address:

Autophagy is a cellular housekeeping and quality control mechanism that is essential for homeostasis and survival. By virtue of this role, any perturbations to the flow of this process in cardiac or vascular cells can elicit harmful effects on the cardiovascular system, and subsequently affect whole organismal health. In this chapter, we summarize the preclinical evidence supporting the role of autophagy in sustaining cardiovascular health during homeostasis and disease. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2020.04.022DOI Listing

Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea is Safe and Effective in Patients with Concomitant Cardiac Devices.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Central sleep apnea is common in heart failure patients. Transvenous phrenic nerve stimulation (TPNS) requires placing a lead to stimulate the phrenic nerve and activate the diaphragm. Data are lacking concerning the safety and efficacy of TPNS in patients with concomitant cardiovascular implantable electronic devices (CIEDs). Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.023DOI Listing

Late atrial arrhythmias after lung transplantation: a meta-analysis.

J Cardiovasc Med (Hagerstown) 2020 Aug;21(8):577-582

Division of Cardiology, Department of Medical Sciences, 'Città della Salute e della Scienza di Torino' Hospital, University of Turin, Turin.

Background: Atrial arrhythmias are common following noncardiac thoracic surgery. In particular, early postoperative atrial arrhythmias after lung transplantation are very frequent, especially atrial fibrillation (AFib). Late atrial arrhythmia occurrence following lung transplantation, instead, has been less commonly reported. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001012DOI Listing

Mechanism of Spontaneous Initiation of Ventricular Fibrillation in Patients with Implantable Defibrillators.

J Cardiovasc Electrophysiol 2020 Jul 3. Epub 2020 Jul 3.

Cardiac Arrhythmia Service, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, Maryland, 21287, USA.

Introduction: To improve the mechanistic understanding of spontaneous initiation of ventricular fibrillation (VF), we characterized the patterns of premature ventricular complex (PVC) preceding spontaneous VF in primary and secondary ICD recipients.

Methods And Results: A single-center, cross-sectional analysis of 1209 patients with primary and secondary prevention ICD identified 190 patients who received ICD therapy (firing or anti-tachycardia pacing) for VF or monomorphic ventricular tachycardia (MMVT). Initiation was quantified by the coupling interval (CI), the cycle length immediately preceding the CI [CL(-1)], the CI corrected by CL(-1) using Fridericia's formula (CIc), and the prematurity index (PI). Read More

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http://dx.doi.org/10.1111/jce.14648DOI Listing

Electrocardiographic Localization of Ventricular Arrhythmias Successfully Ablated from the Distal Great Cardiac Vein.

J Cardiovasc Electrophysiol 2020 Jul 3. Epub 2020 Jul 3.

Northwell Health, Division of Electrophysiology, Manhasset, New York, USA.

Background: Idiopathic ventricular arrhythmias (IVA) from the left ventricular (LV) summit may be successfully ablated from the distal great cardiac vein (dGCV). Using a 12-lead electrocardiogram (ECG) to localize IVAs that can be ablated from the dGCV is valuable for ablation planning.

Objective: To determine if a "w" wave, a notch in the q wave in lead I, and other ECG features can identify IVAs that can be successfully ablated from the dGCV. Read More

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http://dx.doi.org/10.1111/jce.14650DOI Listing

Evaluation of a Novel Antiplatelet Therapy Strategy in Patients Undergoing Elective Percutaneous Coronary Intervention.

J Pharm Pract 2020 Jul 3:897190020933469. Epub 2020 Jul 3.

Division of Cardiology, VA San Diego Healthcare System, San Diego, CA, USA.

Background: Ticagrelor presents less thrombotic risk compared to clopidogrel in acute coronary syndromes. However, its role in dual antiplatelet therapy (DAPT)-naive patients with stable ischemic heart disease (SIHD) undergoing elective percutaneous intervention (PCI) remains unclear, including uncertainty in the method of conversion to clopidogrel for adequate coverage without increased bleeding risk.

Objective: Determine the safety and efficacy of ticagrelor loading and transitioning to clopidogrel in patients with SIHD undergoing elective PCI. Read More

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http://dx.doi.org/10.1177/0897190020933469DOI Listing

The molecular genetic basis of atrial fibrillation.

Hum Genet 2020 Jul 2. Epub 2020 Jul 2.

Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, 466 Newport Middle Road, Haizhu District, Guangzhou, 510317, Guangdong, China.

As the most common cardiac arrhythmia, atrial fibrillation (AF) is a major risk factor for stroke, heart failure, and premature death with considerable associated costs. However, no available treatment options have optimal benefit-harm profiles currently, reflecting an incomplete understanding of the biological mechanisms underlying this complex arrhythmia. Recently, molecular epidemiological studies, especially genome-wide association studies, have emphasized the substantial genetic component of AF etiology. Read More

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http://dx.doi.org/10.1007/s00439-020-02203-wDOI Listing

Atrial pacing and administration of nifekalant hydrochloride for unstable atrial fibrillation: a case report.

Eur Heart J Case Rep 2020 Jun 14;4(3):1-5. Epub 2020 May 14.

Department of Cardiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, Fukuoka 810-8563, Japan.

Background: Atrial fibrillation (AF) is a common arrhythmia in patients with hypertrophic cardiomyopathy (HCM) and can deteriorate haemodynamic status.

Case Summary: We report a case of a 77-year-old woman with cardiogenic shock due to paroxysmal AF, complicated with HCM and aortic stenosis. Atrial fibrillation was successfully managed with temporary atrial pacing and administration of nifekalant hydrochloride without invasive mechanical circulatory support until surgery. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319856PMC

Anomalous left coronary artery from the pulmonary artery: a rare cause of an out-of-hospital cardiac arrest in an adult-a case report.

Eur Heart J Case Rep 2020 Jun 17;4(3):1-5. Epub 2020 Apr 17.

Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

Background: Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital disorder resulting in ischaemia and myocardial infarction which can act as a potential substrate for life-threatening arrhythmias and sudden cardiac death.

Case Summary: A 19-year-old man was admitted to the hospital after successful resuscitation from an out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation occurring during jogging. In the diagnostic work-up of the OHCA, computed tomography identified an ALCAPA. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319838PMC

Deleterious effect of right ventricular pacing in patients with cardiac transthyretin amyloidosis: potential clinical benefit of cardiac resynchronization therapy.

Eur Heart J Case Rep 2020 Jun 1;4(3):1-5. Epub 2020 May 1.

Cardiology Department, GCS-Groupement des Hôpitaux de l'Institut Catholique Lillois/Faculté de médecine et de maïeutique, UCLille, F-59000 Lille, France.

Background: Cardiac amyloidosis involvement is associated with a detrimental outcome including frequent arrhythmias, heart failure, and conduction disturbances which may need permanent pacing.

Cases Summary: We report two cases of patients with transthyretin amyloidosis (ATTR) who developed heart failure and depressed left ventricular ejection fraction (LVEF) following permanent right ventricular (RV) pacing but highly responded to cardiac resynchronization therapy (CRT).

Discussion: The impact of RV pacing and CRT in cardiac amyloidosis is not known. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319833PMC

Coronavirus Disease 2019 Myocarditis: Insights into Pathophysiology and Management.

Eur Cardiol 2020 Feb 17;15:e51. Epub 2020 Jun 17.

Department of Cardiology, Faculty of Medicine, Alexandria University Alexandria, Egypt.

The world is dealing with a global pandemic of severe acute respiratory coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19), which is the illness caused by SARS-CoV-2, is overwhelming healthcare systems around the world. Although the main clinical manifestations of COVID-19 are respiratory symptoms, several reports have noted myocarditis, cardiomyopathy, arrhythmias and cardiac arrests as COVID-19 complications. Read More

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http://dx.doi.org/10.15420/ecr.2020.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325211PMC
February 2020

Dietary supplementation of 25-hydroxycholecalciferol improves cardiac function and livability in broiler breeder hens-amelioration of blood pressure and vascular remodeling.

Poult Sci 2020 Jul 17;99(7):3363-3373. Epub 2020 Apr 17.

Department of Animal Science, National Chung Hsing University, Taichung, Taiwan; Innovation and Development Center of Sustainable Agriculture (IDCSA), National Chung Hsing University, Taichung, Taiwan; The IEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Research Center for Sustainable Energy and Nanotechnology, National Chung Hsing University, Taichung, Taiwan. Electronic address:

A supplement of 69 μg 25-hydroxycholecalciferol (25-OH-D3)/kg feed suppressed the mortality in feed-restricted broiler breeder hens and in hens allowed ad libitum feed intake (Ad-hens) in a feeding trial from age 26 to 60 wk. Outcomes for the mechanisms found that 25-OH-D3 relieved systemic hypoxia, pathological cardiac remodeling and arrhythmias, and hepatopathology to improve hens' livability. In the study, we further evaluated the effect of 25-OH-D3 on blood pressure and vascular remodeling relative to cardiac pathogenesis of sudden death (SD). Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.015DOI Listing

Sudden cardiac death in COVID-19 patients, a report of three cases.

Future Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Associate Professor of Cardiology, Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

The mortality rate of coronavirus disease-19 (COVID-19) has been reported as 1-6% in most studies. The cause of most deaths has been acute pneumonia. Nevertheless, it has been noted that cardiovascular failure can also lead to death. Read More

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http://dx.doi.org/10.2217/fca-2020-0082DOI Listing

Yield and clinical significance of genetic screening in elite and amateur athletes.

Eur J Prev Cardiol 2020 Jul 2:2047487320934265. Epub 2020 Jul 2.

CEINGE - Biotecnologie Avanzate, Italy.

Aims: The purpose of this study was to assess the value of genetic testing in addition to a comprehensive clinical evaluation, as part of the diagnostic work-up of elite and/or amateur Italian athletes referred for suspicion of inherited cardiac disease, following a pre-participation screening programme.

Methods: Between January 2009-December 2018, of 5892 consecutive participants, 61 athletes were investigated: 30 elite and 31 amateur athletes. Elite and amateur athletes were selected, on the basis of clinical suspicion for inherited cardiac disease, from two experienced centres for a comprehensive cardiovascular evaluation. Read More

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http://dx.doi.org/10.1177/2047487320934265DOI Listing

High-intensity endurance training is associated with left atrial fibrosis.

Am Heart J 2020 May 30;226:206-213. Epub 2020 May 30.

Comprehensive Arrhythmia Research & Management Center (CARMA) University of Utah, Salt Lake City, UT; Tulane University Heart and Vascular Institute, New Orleans, LA.

Introduction: Endurance athletes are at higher risk for developing atrial fibrillation as compared to the general population. The exact mechanism to explain this observation is incompletely understood. Our study aimed to determine whether degree of left atrial fibrosis detected by late gadolinium-enhancement magnetic resonance imaging (LGE-MRI) differed between Masters athletes and non-athlete controls. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.015DOI Listing

Should we still monitor QTc duration in frail older patients on low-dose haloperidol? A prospective observational cohort study.

Age Ageing 2020 Jul 2. Epub 2020 Jul 2.

Cardiology Department, Maastricht University Medical Centre, Maastricht 6229 HX, The Netherlands.

Background: Haloperidol at high dosage is associated with QTc prolongation and polymorphic ventricular arrhythmia but the effects of low-dose haloperidol remain unknown.

Objective: To evaluate the effects of low-dose haloperidol on QTc-duration in frail hospitalized elderly patients with delirium.

Methods: A prospective observational study including hospitalized patients aged ≥70 years with Groningen Frailty Index-score > 3. Read More

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http://dx.doi.org/10.1093/ageing/afaa066DOI Listing

Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling.

JACC Basic Transl Sci 2020 Jun 22;5(6):579-581. Epub 2020 Jun 22.

Department of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jacbts.2020.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315227PMC

Association of Atrial Fibrillation Episode Duration With Arrhythmia Recurrence Following Ablation: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open 2020 Jul 1;3(7):e208748. Epub 2020 Jul 1.

Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada.

Importance: Contemporary guidelines recommend that atrial fibrillation (AF) be classified based on episode duration, with these categories forming the basis of therapeutic recommendations. While pragmatic, these classifications are not based on pathophysiologic processes and may not reflect clinical outcomes.

Objective: To evaluate the association of baseline AF episode duration with post-AF ablation arrhythmia outcomes. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.8748DOI Listing

Hot balloon vs. cryoballoon ablation for persistent atrial fibrillation: lesion area, efficacy, and safety.

J Cardiovasc Electrophysiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

Introduction: The clinical efficacy and safety of hot balloon ablation (HBA) for treatment of persistent AF (PerAF) remain unclear. We aimed to evaluate the clinical efficacy and safety of HBA vs. cryoballoon ablation (CBA) as treatment for PerAF. Read More

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http://dx.doi.org/10.1111/jce.14646DOI Listing