1,707 results match your criteria Arquivos brasileiros de endocrinologia e metabologia[Journal]


PTPN2 gene polymorphisms are associated with type 1 diabetes mellitus in Brazilian subjects?

Arq Bras Endocrinol Metabol 2014 Dec;58(9):980-1

Laboratory of Human Pancreatic Islet Biology, Endocrine Division, Hospital de Clínicas de Porto Alegre, Brazil.

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http://dx.doi.org/10.1590/0004-2730000003664DOI Listing
December 2014
1 Read

PTPN2, a potential therapeutic target for type 1 diabetes?

Arq Bras Endocrinol Metabol 2014 Dec;58(9):978-9

Department of Health Evaluation, Shanghai Pudong Institute for Health Development, Shanghai, PR China.

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http://dx.doi.org/10.1590/0004-2730000003561DOI Listing
December 2014
3 Reads

Response to the letter: Red cell distribution width in subclinical hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):976-7

Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Eulji University Hospital, Daejeon, Republic of Korea.

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0004-2730000003552DOI Listing
December 2014
6 Reads

Red cell distribution width in subclinical hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):974-5

Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.

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http://dx.doi.org/10.1590/0004-2730000003452DOI Listing
December 2014
2 Reads

Response to the letter: Angiotensin-II induced insulin resistance.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):972-3

Endocrinology Unit, University Hospital of Los Andes, Mérida, Venezuela.

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http://dx.doi.org/10.1590/0004-2730000003649DOI Listing
December 2014

Angiotensin-II induced insulin resistance.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):970-1

Department of Endocrinology and Metabolism, Ankara Numune Research and Training Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1590/0004-2730000003260DOI Listing
December 2014
2 Reads

[Giant metastasis of thyroid papillar carcinoma].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):967-9

Departamento de Cirurgia de Cabeça e Pescoço, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/0004-2730000003387DOI Listing
December 2014
27 Reads

A case of thyroid hormone resistance: a rare mutation.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):962-6

Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal.

Reduced sensitivity to thyroid hormones (RSTH) is a rare disease that affects about 3,000 individuals, belonging to about 1,000 families. It results from reduced intracellular action of thyroid hormones (TH) genetically determined and manifests as persistent hyperthyroxinemia with non-suppressed thyroid-stimulating hormone (TSH). We describe a 67-years old, Caucasian woman, with past history of subtotal thyroidectomy due to diffuse goiter, who presents with a recurrence of goiter. Read More

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http://www.scielo.br/pdf/abem/v58n9/0004-2730-abem-58-9-0962
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http://dx.doi.org/10.1590/0004-2730000003297DOI Listing
December 2014
11 Reads

Large thyroid cyst in a patient with congenital hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):958-61

Department of Nuclear Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Thyroid hormone biosynthetic defects are rare causes of congenital hypothyroidism. Although, initial presentations are usually diffuse goiter and hypothyroidism, subsequently they may develop thyroid nodules and or thyroid cancer. We describe a case of hypothyroidism due to dyshormonogenesis whose one of the previously solid nodules degenerates into a large cyst. Read More

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http://dx.doi.org/10.1590/0004-2730000003287DOI Listing
December 2014

Marrow hypoplasia: a rare complication of untreated Grave's disease.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):953-7

Institute of Diabetes and Endocrinology Luiz Capriglione, Rio de Janeiro, RJ, Brazil.

Atypical presentation forms of hyperthyroidism are always a challenge to the clinician. We present a female patient with the typical symptoms of thyrotoxicosis, without any thionamides treatment before, associated with pancytopenia, which recovered after euthyroidism state was achieved. Although the major cases of pancytopenia in Grave's disease are seen as a complication of antithyroid drugs (thioamides), in this case report the alteration in blood tests was associated with untreated hyperthyroidism. Read More

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http://dx.doi.org/10.1590/0004-2730000003216DOI Listing
December 2014
7 Reads

[Reduction of functional mobility and cognitive capacity in type 2 diabetes mellitus].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):946-52

LIM-18, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Objectives: The aim of the present study was to evaluate the functional mobility and its relationship to cognitive ability in patients with type 2 diabetes (T2DM), age between 50 and 65 years and under 10 years of diagnosis.

Materials And Methods: An observational, analytical and cross-sectional study, involving no diabetic and type 2 diabetic individuals with inadequate glycemic control, selected by convenience sampling. In both groups, were administered structured questionnaire and cognitive assessment with Mini-Mental State Examination (MMSE) and the clock drawing test (CDT), besides assessment of functional mobility by the Timed Up & Go (TUG). Read More

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http://dx.doi.org/10.1590/0004-2730000003097DOI Listing
December 2014
1 Read

Evaluation of cytopathological findings in thyroid nodules with macrocalcification: macrocalcification is not innocent as it seems.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):939-45

Department of Endocrinology and Metabolism, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey.

Objective: Microcalcification is strongly correlated with papillary thyroid cancer. It is not clear whether macrocalcification is associated with malignancy. In this study, we aimed to assess the result of fine needle aspiration biopsies (FNAB) of thyroid nodules with macrocalcifications. Read More

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http://dx.doi.org/10.1590/0004-2730000003602DOI Listing
December 2014
15 Reads

Thyroid nodules and thyroid cancer in Graves' disease.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):933-8

Department of Endocrinology and Metabolism, Yıldırım Beyazıt University, Ankara, Turkey.

Objective: The frequency of thyroid nodules accompanying Graves' disease and the risk of thyroid cancer in presence of accompanying nodules are controversial. The aim of this study was to evaluate the frequency of thyroid nodules and the risk of thyroid cancer in patients operated because of graves' disease.

Subjects And Methods: Five hundred and twenty-six patients in whom thyroidectomy was performed because of Graves' disease between 2006 and 2013 were evaluated retrospectively. Read More

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http://dx.doi.org/10.1590/0004-2730000003569DOI Listing
December 2014
35 Reads

The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):926-32

Medical University of Sofia, University Hospital of Endocrinology, Sofia, Bulgaria.

Objective: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects.

Materials And Methods: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14. Read More

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http://dx.doi.org/10.1590/0004-2730000003538DOI Listing
December 2014
1 Read

The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):918-25

Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Objective: The aim of this study was to investigate the association between the rs7903146 (C/T) polymorphism in the TCF7L2 gene and type 2 diabetes mellitus, in a Southern-Brazilian population.

Materials And Methods: The TCF7L2 rs7903146 polymorphism was genotyped in 953 type 2 diabetic patients and 535 non-diabetic subjects. All subjects were white. Read More

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http://dx.doi.org/10.1590/0004-2730000003510DOI Listing
December 2014
11 Reads

Evaluation of percutaneous ethanol injections in benign thyroid nodules.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):912-7

Department of Endocrinology and Metabolism, Hospital de Clinicas, Federal University of Paraná, Curitiba, PR, Brazil.

Objective: The objective of this study was to evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules.

Subjects And Methods: We evaluated 120 patients with benign thyroid nodules. Patients underwent evaluation of serum TSH and free T4, cervical ultrasound, and thyroid scintigraphy (in those with suppressed TSH levels). Read More

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http://dx.doi.org/10.1590/0004-2730000003444DOI Listing
December 2014
4 Reads

An international survey of screening and management of hypothyroidism during pregnancy in Latin America.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):906-11

Department of Biorregulation, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil.

Objective: To determine how endocrinologists in Latin America deal with clinical case scenarios related to hypothyroidism and pregnancy.

Materials And Methods: In January 2013, we sent an electronic questionnaire on current practice relating to management of hypothyroidism in pregnancy to 856 members of the Latin American Thyroid Society (LATS) who manage pregnant patients with thyroid disease. Subsequently, we have analyzed responses from physician members. Read More

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http://dx.doi.org/10.1590/0004-2730000003382DOI Listing
December 2014
31 Reads
1 Citation
0.682 Impact Factor

[Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):900-5

Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.

Objective: To assess the association of the G54D (rs1800450) polymorphism of the gene MBL2 in the gestational diabetes mellitus with the need for additional treatment and the occurrence of large newborns for the gestational age.

Subjects And Methods: One hundred and five patients recruited in Joinville--Brazil were evaluated between November 2010 and October 2012. Pregnant women were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. Read More

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http://dx.doi.org/10.1590/0004-2730000002819DOI Listing
December 2014

Brown adipose tissue: what have we learned since its recent identification in human adults.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):889-99

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Brown adipose tissue, an essential organ for thermoregulation in small and hibernating mammals due to its mitochondrial uncoupling capacity, was until recently considered to be present in humans only in newborns. The identification of brown adipose tissue in adult humans since the development and use of positron emission tomography marked with 18-fluorodeoxyglucose (PET-FDG) has raised a series of doubts and questions about its real importance in our metabolism. In this review, we will discuss what we have learnt since its identification in humans as well as both new and old concepts, some of which have been marginalized for decades, such as diet-induced thermogenesis. Read More

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http://dx.doi.org/10.1590/0004-2730000003492DOI Listing
December 2014
12 Reads

Bariatric surgery--an update for the endocrinologist.

Authors:
Marcio C Mancini

Arq Bras Endocrinol Metabol 2014 Dec;58(9):875-88

Endocrinology & Metabolism Department, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Obesity is a major public health problem, is associated with increased rates of mortality risk and of developing several comorbidities, and lessens life expectancy. Bariatric surgery is the most effective treatment for morbidly obese patients, reducing risk of developing new comorbidities, health care utilization and mortality. The establishment of centers of excellence with interdisciplinary staff in bariatric surgery has been reducing operative mortality in the course of time, improving surgical safety and quality. Read More

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http://dx.doi.org/10.1590/0004-2730000003413DOI Listing
December 2014
3 Reads

Images in endocrinology: multinodular goitre.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):873-4. Epub 2014 Nov 1.

Department of Diagnostic Sciences, Division of Radiology and Interventional Radiology, San Carlo Borromeo Hospital.

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November 2014
6 Reads

Breast cancer metastasis to the pituitary gland.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):869-72. Epub 2014 Nov 1.

Department of Endocrinology, Hospital Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil.

Metastatic tumors to the pituitary gland are an unusual complication typically seen in elderly patients with diffuse malignant disease. Breast and lung are the commonest sites of the primary tumor. Prognosis of patients with breast cancer metastasis is poor and depends on the primary neoplastic extension. Read More

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November 2014
1 Read

IgG4-related Hashimoto's thyroiditis--a new variant of a well known disease.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):862-8. Epub 2014 Nov 1.

Department of Endocrinology and Diabetology, Hospital Garcia de Orta, Almada, Portugal.

Hashimoto's thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered a heterogeneous disease. IgG4-related HT is a new subtype characterized by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic IgG4-related disease. Read More

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November 2014
7 Reads

[Clinical heterogeneity of atypical fractures during prolonged use of bisphosphonates--risk factors and bone turnover markers].

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):855-61. Epub 2014 Nov 1.

Departamento de Clínica Médica do Hospital de Clínicas, UFPR, Curitiba, PR, Brasil.

We describe four cases of atypical femoral fractures treated at the Department of Endocrinology, Hospital de Clínicas, Federal University of Paraná (SEMPR) which, although characteristic of this type of fracture, presented clinical peculiarities that should be considered and serve as a warning in these patients, such as: late diagnosis with maintenance of bisphosphonates; absence of co-morbidities with excellent result; failure of fracture healing; use of anabolic medication after the fracture and the use of bone turnover markers at the follow up. Read More

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November 2014
49 Reads

Papillary thyroid cancer case masked by subacute thyroiditis.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):851-4. Epub 2014 Nov 1.

Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey.

Subacute thyroiditis (SAT) association with thyroid carcinoma has been rarely reported in the literature. We present a patient with SAT and papillary thyroid cancer that was suspected by ultrasonographic evaluation (US) following SAT treatment. A fifty-four-year old female patient referred to our department due to tachycardia, jitteriness and pain in cervical region for the past one month. Read More

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November 2014
5 Reads
2 Citations
0.682 Impact Factor

Determination of cortisol and cortisone in human saliva by a liquid chromatography-tandem mass spectrometry method.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):844-50. Epub 2014 Nov 1.

Steroid Laboratories, Grupo Fleury, São Paulo, SP, Brazil.

Objective: Salivary cortisol measurement plays an important role in the evaluation of adrenal function. Its high correlation with free serum cortisol, the easy of sampling and the limited presence of interfering steroids, generated multiple recent studies of its application, in special in the screening of adrenal hyperfunction. In this paper we present our experience in the development of a high pressure liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for salivary cortisol and cortisone measurement. Read More

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November 2014
2 Reads

[Old and new anthropometric indices as insulin resistance predictors in adolescents].

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):838-43. Epub 2014 Nov 1.

Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil.

Objective: Despite the importance of insulin resistance (IR) on chronic diseases development, its diagnosis remains invasive. Thus, it's necessary to develop alternative methods to predict IR on clinical practice, and the anthropometric indices are a good alternative to it. Given that, this study's purpose is to evaluate these indices behavior in relation to HOMA-IR (Homeostasis Model Assessment of Insulin Resistance). Read More

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November 2014
2 Reads

Short-term effects of triiodothyronine on thyroid hormone receptor alpha by PI3K pathway in adipocytes, 3T3-L1.

Arq Bras Endocrinol Metabol 2014 Nov;58(8):833-7

Department of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, Botucatu, SP, Brazil.

Objective: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRα) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.

Materials And Methods: It was examined the involvement of PI3K pathway in mediating T3 effects by treating 3T3-L1 adipocytes with physiological (P=10nM) or supraphysiological (SI =100 nM) T3 doses during one hour (short time), in the absence or the presence of PI3K inhibitor (LY294002). The absence of any treatment was considered the control group (C). Read More

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November 2014
6 Reads

Mutation screening of the sodium iodide symporter gene in a cohort of 105 China patients with congenital hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):828-32. Epub 2014 Nov 1.

Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region.

Objective: Dyshormonogenetic congenital hypothyroidism (CH) was reported to be associated with a mutation in the sodium iodide symporter (NIS) gene. The present study was undertaken in the Guangxi Zhuang Autonomous Region of China, to determine the nature and frequency of NIS gene mutations among patients with CH due to dyshormonogenesis.

Subjects And Methods: Blood samples were collected from 105 dyshormonogenetic CH patients in Guangxi Zhuang Autonomous Region, China, and genomic DNA was extracted from peripheral blood leukocytes. Read More

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November 2014
1 Read

Thyroid volume in patients with glucose metabolism disorders.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):824-7. Epub 2014 Nov 1.

Department of Endocrinology and Metabolism, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objective: Thyroid volume and the prevalence of thyroid nodules are higher in patients with insulin resistance. A relationship between thyroid volume and glucose metabolism disorders (GMD) has not as yet been clarified. The present retrospective study aimed to investigate the association between GMD and thyroid volume. Read More

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November 2014
39 Reads

Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):817-23. Epub 2014 Nov 1.

Department of Cardiovascular Diseases, West China Hospital, School of Clinical Medicine, Sichuan University, Chengdu, China.

Objective: This meta-analysis aimed to investigate the association of leptin levels with pathogenetic risk of CHD and stroke.

Materials And Methods: Studies were identified in the PubMed, Embase, and Springer link database without language restriction. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used as effect indexes. Read More

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November 2014
5 Reads

Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor?

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):812-6. Epub 2014 Nov 1.

Endocrinology Service, Santa Casa de Belo Horizonte, MG, Brazil.

Objective: To determine whether the currently recommended therapy for papillary thyroid carcinoma (PTC) that show no classical factors indicating a poor prognosis is also effective in cases with a family history of this tumor.

Subjects And Methods: Forty-two patients were studied; 10 were submitted to lobectomy and 32 to total thyroidectomy, including 23 without lymph node dissection and 9 with lymph node dissection. None of the patients received radioiodine or was maintained under TSH suppression. Read More

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November 2014
3 Reads

Screening for acromegaly in adult patients not reporting enlargement of the extremities, but with arterial hypertension associated with another comorbidity of the disease.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):807-11. Epub 2014 Nov 1.

Neuroendocrinology Department, Santa Casa de Belo Horizonte, Brazil.

Objective: To determine the value of acromegaly screening in adult patients not reporting enlargement of the extremities, but who present arterial hypertension associated with at least one other comorbidity of the disease.

Subjects And Methods: Patients seen by general practitioners at primary health care units were evaluated. Among the patients without extremity enlargement, those with recently diagnosed arterial hypertension associated with at least one other comorbidity were selected. Read More

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November 2014
3 Reads

Sitting-height measures are related to body mass index and blood pressure levels in children.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):802-6. Epub 2014 Nov 1.

Universidade de São Paulo, Universidade Federal do Espírito Santo, UVV, Vila Velha, ES, Brazil.

Objective: Sitting height (SH) is an important parameter in the evaluation of children with growth and pubertal disorders. Besides this, it has been viewed as a biomarker of cardiovascular risk, which is increased in adults with relatively short legs. So, the aim of this study was to evaluate the relationship between body proportions and cardiovascular risk markers in children. Read More

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November 2014
7 Reads

Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):798-801. Epub 2014 Nov 1.

Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.

Objective: To evaluate the clinical usefulness of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion for the detection of early tubular damage in type 2 diabetes mellitus (T2DM).

Subjects And Methods: Thirty six patients with T2DM were divided into two groups based on urinary albumin to creatinine ratio (ACR): normoalbuminuria (ACR <30 mg/g; n=19) and microalbuminuria (ACR =30-300 mg/g; n=17). The following parameters were determined in both groups: urinary NAG and albumin, serum and urine creatinine, fasting plasma glucose and glycated hemoglobin (HbA1c). Read More

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November 2014
2 Reads

Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):783-97. Epub 2014 Nov 1.

Department of Genome Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence from the literature, and demonstrating the effect of LRT in LS patients. Read More

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November 2014
9 Reads

[Thyrotoxic hypokalemic periodic paralysis in patients of African descent].

Arq Bras Endocrinol Metabol 2014 Oct;58(7):779-81

Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Brasil.

Thyrotoxic hypokalemic periodic paralysis (THPP) is an endocrine emergency marked by recurrent attacks of muscle weakness associated with hypokalemia and thyrotoxicosis. Asiatic male patients are most often affected. On the other hand, African descents rarely present this disease. Read More

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October 2014
8 Reads

A rare case of a parathyroid adenoma inside a parathyroid cyst.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):776-8

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Parathyroid cysts (PCs) are rare lesions, located in the neck and anterior mediastinal region. The vast majority are non-functioning, presented as nodular cervical lesions. Large, non-functioning PCs can manifest with compressive symptoms of the surrounding tissues. Read More

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October 2014
1 Read

Maturity onset diabetes of young type 2 due to a novel de novo GKC mutation.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):772-5

Centro Hospitalar Barreiro Montijo, Hospital Nossa Senhora do Rosário, Portugal.

Maturity Onset Diabetes of Young (MODY) is a heterogeneous group of monogenic disorders that result in β-cell dysfunction, with an estimated prevalence of 1%-2% in industrialized countries. MODY generally occurs in non-obese patients with negative autoantibodies presenting with mild to moderate hyperglycemia. The clinical features of the patients are heterogeneous, depending on the different genetic subtypes. Read More

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October 2014
2 Reads

Ten-year evaluation of a Neonatal Screening Program for congenital adrenal hyperplasia.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):765-71

Endocrine Pediatric Department, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil.

Objective: Evaluate the Neonatal Screening Program (NSP) for congenital adrenal hyperplasia (CAH) of the Department of Health of the State of Santa Catarina (Secretaria de Estado da Saúde de Santa Catarina, SES/SC), and provide information to improve the program.

Subjects And Methods: Descriptive, retrospective study of 748,395 children screened between January 2001 and December 2010. We analyzed the coverage of the NSP-SES/SC prevalence of CAH, child's age when the first sample for 17-hydroxyprogesterone (17OHP) measurement was collected, levels of 17OHP, mean age at treatment onset and main clinical manifestations. Read More

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October 2014
5 Reads

[Technical and functional aspects of catheterization of inferior petrosal sinuses in ACTH dependent Cushing's syndrome].

Arq Bras Endocrinol Metabol 2014 Oct;58(7):758-64

Departamento de Neurocirurgia, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

Objective: To describe and analyze technique for bilateral catheterization of inferior petrosal sinus in our service, discussing the difficulties and success rates found.

Subjects And Methods: Fourteen patients with suspected Cushing's syndrome underwent bilateral inferior petrosal sinuses (IPS) catheterization between 2009 and 2012. The technique for catheterization and for hormone analysis were described. Read More

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October 2014
38 Reads

[Impairment of muscle vasodilation during mental stress in women with subclinical hypothyroidism].

Arq Bras Endocrinol Metabol 2014 Oct;58(7):750-7

Unidade de Investigação Cardiovascular e Fisiologia do Exercício, Hospital Universitário.

Objective: To test the hypothesis that women with subclinical hypothyroidism (SH) have forearm vascular conductance (FVC) impaired during mental stress.

Subjects And Methods: We evaluated 20 women with SH and 21 euthyroid (Control group), matched for age (p = 0.699) and body mass index (p = 0. Read More

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October 2014
5 Reads

The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):744-9

Tehran University of Medical Sciences, Tehran, Iran.

Objective: Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it's relation with vitamins A, E and C intake in 30 obese women.

Subjects And Methods: General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Read More

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October 2014
9 Reads

Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):737-43

Department of Nutrology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Objective: Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms.

Subjects And Methods: ZnT8A were analyzed in sera from T1D patients (n = 72, mean age of 30. Read More

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October 2014
15 Reads

Is it necessary to increase the dose of levothyroxine in patients with hypothyroidism who use omeprazole?

Arq Bras Endocrinol Metabol 2014 Oct;58(7):731-6

Department of Endocrinology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Objective: It is believed that gastric pH interferes in levothyroxine absorption. Omeprazole, which acts by blocking the secretion of gastric acid, might interfere in hypothyroidism control in patients using levothyroxine and this effect could be dose dependent. The present study aimed to investigate this possibility. Read More

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October 2014
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[Evaluation of fructosamine as a parameter of blood glucose control in diabetic pregnant women].

Arq Bras Endocrinol Metabol 2014 Oct;58(7):724-30

Departamento de Obstetrícia e Ginecologia, Maternidade Professor José Maria de Magalhães Netto, Salvador, BA, Brasil.

Objective: To evaluate the alternative parameters to monitor glycemia in pregnant women with diabetes studying the relationship between fructosamine testing and self monitoring of blood glucose in pregnant women with diabetes.

Materials And Methods: Serum fructosamine levels and the self monitoring of blood glucose over 14 days before the collection of fructosamine were evaluated in 47 diabetic pregnant women.

Results: Seventy-one fructosamine levels and 2,238 glucose measurements (CGs) were analysed. Read More

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October 2014
3 Reads

The prevalence of glucose metabolism disturbances in Chinese Muslims and possible risk factors: a study from northwest China.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):715-23

Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To survey the prevalence of diabetes mellitus (DM) and pre-diabetes mellitus (PDM) in the Muslim population in northwest China, and discuss the risk factor.

Materials And Methods: According to the income and the population, we randomly selected 3 villages with stratified and cluster sampling. The subjects were residents ≥ 20 years of age, and were from families which have been local for > 3 generations. Read More

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October 2014
3 Reads

Serum levels of retinol binding protein 4 in women with different levels of adiposity and glucose tolerance.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):709-14

Laboratory of Investigation on Metabolism and Diabetes, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.

Objective: Retinol-binding protein 4 (RBP4) is an adipokine responsible for vitamin A (retinol) transportation. Studies associated RBP4 increased levels with severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The study aimed to quantify RBP4 serum standards in women with a wide range of body mass index (BMI) and glucose tolerance level. Read More

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October 2014
4 Reads

The role of imaging in congenital adrenal hyperplasia.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):701-8

Division of Radiology, Clinical Hospital, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Congenital adrenal hyperplasia (CAH) is an autossomic recessive disorder caused by impaired steroidogenesis. Patients with CAH may present adrenal insufficiency with or without salt-wasting, as well as various degrees of virilization and fertility impairment, carrying a high incidence of testicular adrenal rest tumors and increased incidence of adrenal tumors. The diagnosis of CAH is made based on the adrenocortical profile hormonal evaluation and genotyping, in selected cases. Read More

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October 2014
13 Reads

Diagnosis, treatment, and follow-up of medullary thyroid carcinoma: recommendations by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism.

Arq Bras Endocrinol Metabol 2014 Oct;58(7):667-700

Divisão de Endocrinologia, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Introduction: Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and represents 3-4% of the malignant neoplasms that affect this gland. Approximately 25% of these cases are hereditary due to activating mutations in the REarranged during Transfection (RET) proto-oncogene. The course of MTC is indolent, and survival rates depend on the tumor stage at diagnosis. Read More

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October 2014
4 Reads