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    1873 results match your criteria Arquivos Brasileiros de Oftalmologia [Journal]

    1 OF 38

    A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):268-272
    Unidade de Oftalmologia, Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, SP, Brazil.
    Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i. Read More

    Bilateral acute angle closure in a patient with dengue fever: a case report.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):266-267
    Hospital General de Agudos Juan A. Fernández, Buenos Aires, Argentina.
    We report the case of a 46-year-old female patient who presented with bilateral acute angle closure during the course of dengue infection. Dengue diagnosis was confirmed by serological tests. The patient had plateau iris configuration identified by ultrasound biomicroscopy. Read More

    Choroidal neovascularization silent on optical coherence tomography: report of two cases.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):263-265
    Department of Ophthalmology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    Herein, we report two cases of vision loss after successful cataract surgery, associated with drusenoid retinal pigment epithelial detachment without features of choroidal neovascularization on optical coherence tomography along with angiographic examinations suggestive of choroidal neovascularization in which anatomical and functional improvements were achieved with intravitreal injections of anti-vascular endothelial growth factor. Read More

    Aqueous misdirection syndrome in persistent fetal vasculature (PFV).
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):260-262
    Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    We report a case of a 5-year-old girl with persistent fetal vasculature who presented with unilateral acute angle closure caused by aqueous misdirection syndrome that was apparently associated with regression of cycloplegia. Initial treatment with topical steroids, anti-glaucomatous drops, and atropine showed insufficient control of the intraocular pressure (IOP). Surgical treatment with lensectomy and vitrectomy resulted in satisfactory IOP control and no complications at the 6-month follow-up. Read More

    Optical coherence tomography angiography artifactual choroidal neovascularization in optic disc pit maculopathy.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):257-259
    Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    This case report describes a 19-year-old Caucasian man presented with decreased visual acuity in the right eye for 3 months. Dilated funds exam revealed optic disk pit associated with serous macular detachment. Optical coherence tomography identified communication between the optic disk pit and the macular serous detachment, and optical coherence tomography angiography displayed a subfoveal area suggestive of subfoveal choroidal neovascularization. Read More

    Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits' eyes.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):252-256
    Department of Statistics, Universidade Estadual de Londrina, Londrina, PR, Brazil.
    Purpose:: To evaluate and compare the effects of topical application and subconjunctival injection of bevacizumab on corneal neovascularization (CNV) in rabbits' eyes after chemical burning of the cornea.

    Methods:: The animals were randomly distributed into four groups of five animals. In one group, the drug was instilled, while in another, it was administered by subconjunctival injection. Read More

    Evaluation of the ocular surface following bariatric surgery.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):247-251
    General Surgery Department, Faculdade de Ciências Médicas da Santa Casa de São Paulo, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
    Purpose:: To identify and evaluate changes in the ocular surface in obese patients with bariatric surgery.

    Methods:: The study included 89 randomly selected patients; 81 (91.0%) were women, 35 were preoperative, 32 were included 0-12 months after surgery, and 22 were included >12 months after surgery. Read More

    Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):242-246
    Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
    Purpose:: To evaluate the clinical results of patients treated by amniotic membrane transplantation (AMT) following excision of conjunctival and limbal tumors.

    Methods:: A total of 14 eyes of 14 patients who underwent AMT after total lesion-free tumor excision and perilesional cryotherapy were evaluated.

    Results:: The excised tumors comprised 7 conjunctival intraepithelial neoplasia, 5 conjunctival nevus, 1 primary acquired melanosis, and 1 squamous cell carcinoma. Read More

    Assessment of eye drop instillation technique in glaucoma patients.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):238-241
    Department of Ophthalmology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Purpose:: To study the technique of eye drop instillation in glaucoma patients and identify independent factors that may influence their performance.

    Methods:: In this cross-sectional study, 71 consecutive patients with glaucoma or ocular hypertension, self-administering topical anti-glaucoma medications for ≥6 months were evaluated. All patients instilled a tear substitute into the eye with the worst eyesight using the technique normally used at home. Read More

    Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):234-237
    Department of Clinical Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey.
    Purpose:: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples.

    Methods:: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Read More

    Vitamin D level in patients with pterygium.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):229-233
    Department of Ophthalmology, Gaziantep University School of Medicine, Gaziantep, Turkey.
    Purpose:: To evaluate blood vitamin D level in patients with pterygium.

    Methods:: This prospective study, compared 58 eyes of 58 healthy individuals (control group) with 63 eyes of 63 patients with pterygium (study group). Subjects were stratified by time spent indoors or outdoors. Read More

    Alternative ways to optimize treatment for retinal vein occlusion with peripheral capillary non-perfusion: a pilot study.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):224-228
    Department of Ophthalmology, First Pavlov State Medical University of St. Petersburg, Saint Petersburg, Russian Federation.
    Purpose:: We compared the efficacy and safety of ranibizumab versus ranibizumab plus scatter laser photocoagulation (SLP) in patients with chronic post-central retinal vein occlusion (CRVO) macular edema (ME).

    Methods:: This prospective non-randomized pilot study included 250 patients with peripheral retinal ischemia and CRVO-related ME. The mean follow-up period was 24. Read More

    Indications for eye removal over a 13-year period at an ophthalmology referral center in São Paulo, Brazil.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):220-223
    Department of Ophthalmology and Visual Sciences, Ocular Oncology Service, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose:: To analyze the indications and types of eye removal at Latin America's highest-volume ophthalmic reference center in São Paulo, Brazil.

    Methods:: A retrospective analysis was conducted of surgical pathological reports in the electronic database of the Ophthalmology Department of the Universidade Federal de São Paulo Hospital of patients who underwent eye-removal procedures between January 2000 and December 2012.

    Results:: A total of 412 cases met the inclusion criteria for this study. Read More

    Retinal function in patients with the neuronal ceroid lipofuscinosis phenotype.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):215-219
    Laboratório de Eletrofisiologia Visual Clínica, Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
    Purpose:: To analyze the clinical features, visual acuity, and full-field electroretinogram (ERG) findings of 15 patients with the neuronal ceroid lipofuscinosis (NCL) phenotype and to establish the role of ERG testing in NCL diagnosis.

    Methods:: The medical records of five patients with infantile NCL, five with Jansky-Bielschowsky disease, and five with juvenile NCL who underwent full-field ERG testing were retrospectively analyzed.

    Results:: Progressive vision loss was the initial symptom in 66. Read More

    Topical tacrolimus for the treatment of severe allergic keratoconjunctivitis in children.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):211-214
    Department of Ophthalmology, Universidade Federal de São Paulo São Paulo, SP, Brazil.
    Purpose:: Administration of eye drops containing antihistamines or sodium cromoglycate and its derivatives for the treatment of allergic keratoconjunctivitis is often insufficient and usually requires the addition of corticosteroids. However, the risk of complications, such as glaucoma and cataract, limits the use of corticosteroids to short courses, resulting in inadequate long-term treatment response. Immunosuppressive drugs have been considered as a valid alternative to steroids for atopic keratoconjunctivitis and vernal keratoconjunctivitis. Read More

    Posterior argentinean flag-like sign during primary posterior continuous curvilinear capsulorhexis.
    Arq Bras Oftalmol 2017 Jun;80(3):199-201
    Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    We describe a unique complication during primary posterior continuous curvilinear capsulorhexis (PCCC) in a patient with megalocornea scheduled for phacoemulsification with toric multifocal intraocular lens (IOL) implantation. After nucleus emulsification and cortex removal, the capsular bag was filled with cohesive viscoelastic in preparation for PCCC to achieve reverse optic capture of the IOL, thus ensuring stability. However, as soon as the initial puncture was made using a 27-gauge needle to start the capsulotomy, the posterior capsule opening extended peripherally from 0º-180º. Read More

    Effects of hemodialysis on corneal and anterior chamber morphometry and intraocular pressure in patients with end-stage renal disease.
    Arq Bras Oftalmol 2017 Jun;80(3):176-180
    Department of Ophthalmology, Ataturk Research and Training Hospital, Ankara, Turkey.
    Purpose: To evaluate the effects of hemodialysis (HD) on corneal and anterior chamber morphometry, as well as intraocular pressure (IOP) in patients with end-stage renal disease.

    Methods: Fifty right eyes were examined 30 minutes before and after HD. IOP was measured with a Goldmann applanation tonometer, and Ehlers' formula was used to calculate the corrected IOP values. Read More

    Ultrasound parameters of normal lacrimal sac and chronic dacryocystitis.
    Arq Bras Oftalmol 2017 Jun;80(3):172-175
    Department of Ophthalmology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To compared the ultrasound findings of the lacrimal sac between subjects with normal lacrimal systems those with chronic dacryocystitis.

    Methods: A retrospective study of 10 subjects with a normal lacrimal system (Group 1) and 10 with chronic dacryocystitis (Group 2) diagnosed according to B-mode ultrasound with a 10-MHz transducer and the direct-contact technique (AVISO, Quantel Medical) for lacrimal sac assessment. We analyzed the dimensions, features, and content of the sacs. Read More

    Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children.
    Arq Bras Oftalmol 2017 Jun;80(3):186-188
    Cornea and External Eye Disease Clinic, Departamento de Oftalmologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To evaluate the use of supratarsal injection of triamcinolone acetonide in severe vernal keratoconjunctivitis (VKC) in children.

    Methods: Patients included in this open clinical trial were those with severe VKC-associated with keratitis, gelatinous limbal infiltrates, and/or giant papillae, with a history of recurrence and resistance to conventional topical antiallergic agents. Patients were treated with a supratarsal injection of 20 mg triamcinolone acetonide. Read More

    Solitary fibrous tumor of the lacrimal gland mimicking pleomorphic adenoma.
    Arq Bras Oftalmol 2017 Jun;80(3):189-191
    Ocular Plastic Sector, Centro de Referência em Oftalmologia, Universidade Federal de Goiás, Goiânia, GO, Brazil.
    Solitary fibrous tumor (SFT) is a rare mesenchymal spindle-cell neoplasm commonly found in the pleura; it is rare in the orbit and extremely rare in the lacrimal gland. We herein report a case of SFT of the lacrimal gland that mimicked a pleo morphic adenoma. We discuss the clinical, radiological, histopathological, and immunohistochemical findings that provided insight and rationale to accurately diagnose this case. Read More

    Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial.
    Arq Bras Oftalmol 2017 Jun;80(3):154-158
    Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, Brazil.
    Purpose: To assess the efficacy of monotherapy using tacrolimus eye drops versus sodium cromoglycate for the treatment of vernal keratoconjunctivitis (VKC).

    Methods: Randomized double-masked controlled trial comparing the efficacy of tacrolimus 0.03% eye drops t. Read More

    Multimodal assessment of patients with chronic central serous chorioretinopathy.
    Arq Bras Oftalmol 2017 Jun;80(3):181-185
    Department of Ophthalmology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
    Purpose: To examine differences between fluorescein angiography (FA) and indocyanine green angiography (ICG) findings in patients with chronic central serous chorioretinopathy (CSC), comparing these with optical coherence tomography (OCT) findings.

    Methods: Ten consecutive patients with chronic CSC (19 eyes; 7 men; mean age, 50.7 ± 8. Read More

    Corneal backscatter in insulin-dependent and non-insulin-dependent diabetes mellitus patients: a pilot study.
    Arq Bras Oftalmol 2017 Jun;80(3):148-153
    Optometry Research Group, Department of Optics & Optometry & Vision Sciences, University of Valencia, Valencia, Spain.
    Purpose: To compare central corneal backscatter obtained from Scheimpflug images between patients with insulin-dependent and non-insulin-dependent diabetes mellitus (IDDM and NIDDM, respectively) and healthy controls.

    Methods: Seven patients with IDDM (7 eyes), eleven patients with NIDDM (11 eyes), and sixteen healthy subjects (16 eyes) were included in this pilot study. Scheimpflug imaging system (Pentacam, Oculus Inc. Read More

    Effects of obesity on retrobulbar flow hemodynamics: color Doppler ultrasound evaluation.
    Arq Bras Oftalmol 2017 Jun;80(3):143-147
    Department of General Surgery, Antalya Training and Research Hospital, Antalya, Turkey.
    Purpose: To evaluate intraocular pressure (IOP) and extraocular orbital vessels with color Doppler ultrasound (CDU) and investigate the effects of obesity on retrobulbar blood flow.

    Methods: Fifty-nine patients were included in this prospective study. Patients were divided into two groups according to body mass index: Group 1 (31 obese patients) and Group 2 (28 non-obese patients). Read More

    Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification.
    Arq Bras Oftalmol 2017 Jun;80(3):165-167
    Oftalmed, Brasília, DF, Brazil.
    Purpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant.

    Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Read More

    Corneal properties and glaucoma: a review of the literature and meta-analysis.
    Arq Bras Oftalmol 2017 Jun;80(3):202-206
    Vision Sciences Study Center, Faculdade de Medicina, Universidade de Lisboa, Portugal.
    Purpose: Studies have suggested that corneal biomechanical properties influence intraocular pressure (IOP) measurements, namely central corneal thickness (CCT) and corneal hysteresis (CH). The present study aimed to investigate the associations of CH and CCT with glaucoma development.

    Methods: We performed a review of the literature and meta-analysis of observational studies (2006-2016) that included both adult glaucoma patients and controls and reported CCT and CH as outcomes. Read More

    Vision status, ophthalmic assessment, and quality of life in the very old.
    Arq Bras Oftalmol 2017 Jun;80(3):159-164
    Departament of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To determine the vision status, ophthalmic findings, and quality of life among the very elderly.

    Methods: This was a cross-sectional observational study of individuals aged 80 years and above. A comprehensive ophthalmic exam was performed with mea surement of both the presenting (PVA) and best-corrected visual acuity. Read More

    Photoreceptor assessment using adaptive optics in resolved central serous chorioretinopathy.
    Arq Bras Oftalmol 2017 Jun;80(3):192-195
    Department of Ophthalmology, Otorhinolaringology and Head and Neck Surgery, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    We present a case of a patient with resolved central serous chorioretinopathy (CSC) in the left eye with persistent mild visual alterations 4 years after the resolution of the disease. Left eye exam revealed a best corrected visual acuity of 20/25 and a slight change of macular pigmentation. Optical coherence tomography revealed only minor irregularities in the topography of retinal pigment epithelium and Bruch's membrane. Read More

    Successful treatment of fungal endophthalmitis using intravitreal caspofungin.
    Arq Bras Oftalmol 2017 Jun;80(3):196-198
    Department of Ophthalmology, University of Medicine and Pharmacy "Gr.T.Popa,", Iasi, Romania.
    Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Read More

    The reasons for evisceration after penetrating keratoplasty between 1995 and 2015.
    Arq Bras Oftalmol 2017 Jun;80(3):168-171
    Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
    Purpose: The purpose of this study was to determine the indications and frequency of evisceration after penetrating keratoplasty (PK).

    Methods: The medical records of all patients who underwent evisceration after PK between January 1, 1995 and December 31, 2015 at Ankara Training and Research Hospital were reviewed. Patient demographics and the surgical indications for PK, diagnosis for evisceration, frequency of evisceration, and the length of time between PK and evisceration were recorded. Read More

    Adjuvant treatment or primary topical monotherapy for ocular surface squamous neoplasia: a systematic review.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):131-136
    Faculdade de Medicina de Marília, Marília, SP, Brazil.
    In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN). The findings were: (i) adjuvant 5-fluorouracil (5-FU) reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR) A]. (ii) Primary topical mitomycin (MMC) produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A). Read More

    Oncocytoma of the lacrimal gland: a case report.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):128-130
    Hospital Oftalmológico de Brasília (HOB), Brasília, DF, Brazil.
    Here we describe a rare case of a benign tumor in the lacrimal gland of a healthy 4-year-old girl. Mild proptosis was the only abnormality observed on clinical examination. Magnetic resonance imaging of the right orbit revealed an oval, solid, well-circumscribed, homogeneous mass extending from the lacrimal gland and measuring 2. Read More

    Ocular sarcoidosis masked by positive IgM for toxoplasmosis.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):125-127
    Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    We report a case of ocular sarcoidosis with positive immunoglobulin (Ig) M and IgG serology for toxoplasmosis. The patient was a young female with red painful eyes, bilateral eyelid edema, and panuveitis with periphlebitis. In laboratory testing, she was IgM and IgG positive for toxoplasmosis and anergic in the tuberculin test. Read More

    Large colloid drusen analyzed with structural en face optical coherence tomography.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):122-124
    Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Drusen are extracellular deposits between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. Large colloid drusen (LCD) are located below the RPE and are characterized by multiple, large, dome-shaped RPE detachments, with marked attenuation of the ellipsoid zone overlaying the drusen. This report presents the structural en face optical coherence tomography (OCT) findings of LCD and relates them to findings from fluorescein and indocyanine green angiography. Read More

    Structure-functional correlation using adaptive optics, OCT, and microperimetry in a case of occult macular dystrophy.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):118-121
    Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
    We report retinal functional and structural changes of a 40-year-old man diagnosed with occult macular dystrophy. Comprehensive ophthalmological evaluation was performed, followed by spectral-domain optical coherence tomography (SD-OC - Heidelberg) and image acquisition using an adaptive optics (AO) camera (RTX1, Imagine Eyes) for photoreceptor density analysis. Functional tests included full-field ERG (ERG) and multifocal electroretinography (mfERG) (Diagnosys, LLC) and microperimetry with scanning laser ophthalmoscope (SLO) fixation controlled (MAIA, CenterVUE). Read More

    Iris-claw intraocular lens implantation in children with ectopia lentis.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):114-117
    Department of Ophthalmology, Görükle Kampüs, Uludag University, Bursa, Turkey.
    Purpose:: Artisan iris-claw lens implantation (AICLI) is a surgical technique for treating ectopia lentis. We aimed to compare visual outcomes and possible long-term complications of AICLI surgery in pediatric patients with ectopia lentis with or without a diagnosable hereditary disease.

    Methods:: Seventeen children with non-traumatic ectopia lentis were retros pectively classified into two groups: group 1 included children with a diagnosable hereditary disease (11 patients, 65%), and group 2 included children without any definable hereditary disease (six patients, 35%). Read More

    Quality of bevacizumab (Avastin®) repacked in single-use glass vials for intravitreal administration.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):108-113
    Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    Purpose:: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its division into single-use vials to meet the low volume and low-cost doses necessary for intraocular administration. However, the safety of compounding the drug in single-use vials is still under discussion. Read More

    Outcomes of phacoemulsification in patients with uveitis at a tertiary center in São Paulo, Brazil: a review of cases from 2007 to 2012.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):104-107
    Departament of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
    Purpose:: To evaluate the outcomes of phacoemulsification with intraocular lens (IOL) implantation in eyes with uveitis.

    Methods:: Consecutive patients with uveitis and cataracts who had phacoemulsification and acrylic IOL implantation during 2007-2012 were evaluated for visual outcomes, etiology, and complications. Inflammation was controlled for at least 3 months before surgery, and oral prednisone (0. Read More

    Incidence of anterior segment neovascularization during intravitreal treatment for macular edema secondary to central retinal vein occlusion.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):97-103
    Department of Ophthalmology, Universidade Federal de São Paulo, SP, Brazil.
    Purpose:: To analyze the effects of injections of intravitreal triamcinolone acetonide (IVTA) and intravitreal bevacizumab (IVB) on the incidence rates of anterior segment neovascularization (ASN) and neovascular glaucoma (NVG) in patients with macular edema secondary to central retinal vein occlusion (CRVO).

    Methods:: In this prospective, randomized, double-masked, sham-controlled study, 35 patients with macular edema following CRVO were randomized to intravitreal bevacizumab, intravitreal triamcinolone acetonide, or sham injections during the first 6 months of the study. The primary outcome was the incidence rate of ASN at month 6. Read More

    Topographic outcomes after corneal collagen crosslinking in progressive keratoconus: 1-year follow-up.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):93-96
    Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
    Purpose:: We aimed to report and analyze topographic and refractive outcomes following corneal collagen crosslinking (CXL) in patients with progressive keratoconus (KC).

    Methods:: We performed a retrospective, analytical, and observational study of 100 eyes from 74 progressive KC patients who underwent CXL at the Eye Hospital of Paraná. Keratometric values were analyzed preoperatively as well as 3 and 12 months postoperatively. Read More

    Keratoconus progression is not inhibited by reducing eyelid muscular force with botulinum toxin A treatment: a randomized trial.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):88-92
    Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Purpose:: To evaluate whether reducing eyelid muscular force through the administration of botulinum toxin type A (BTX-A) to the orbicularis oculi muscles of patients with keratoconus affected corneal parameters indicative of disease progression.

    Methods:: In this prospective parallel randomized clinical trial, 40 eyes of 40 patients with keratoconus were randomized into equally sized control and BTX-A groups. Patients in the BTX-A group received subcutaneous BTX-A injections into the orbicularis muscle. Read More

    Detection of herpes simplex-1 and -2 and varicella zoster virus by quantitative real-time polymerase chain reaction in corneas from patients with bacterial keratitis.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):84-87
    Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Objective:: Bacterial keratitis occurs worldwide, and despite recent developments, it remains a potentially blinding condition. This study assesses the presence of herpes simplex virus (HSV-1 and -2) and varicella zoster virus (VZV) by quantitative real-time polymerase chain reaction (qPCR) in corneal scrapings from patients with bacterial keratitis.

    Methods:: A total of 65 patients with clinical diagnoses of infectious corneal ulcers prospectively underwent clinical eye examinations. Read More

    Comparisons of choroidal nevus measurements obtained using 10- and 20-MHz ultrasound and spectral domain optical coherence tomography.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):78-83
    Department of Ophthalmology, Universidade Federal de São Paulo, SP, Brazil.
    Purpose:: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US).

    Methods:: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results). Anteroposterior (AP) and transverse (T) US sections corresponded to sections adjusted perpendicularly on SD-OCT. Read More

    Evaluation of nicotinamide as an anti-inflammatory and anti-angiogenic agent in uveal melanoma cell lines.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):74-77
    Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, Quebec, Canada.
    Purpose:: To investigate the effect of nicotinamide on the secretion of pro-an giogenic and pro-inflammatory cytokines in uveal melanoma cell lines.

    Methods:: Two human uveal melanoma cell lines (92.1 and OCM-1) were treated with nicotinamide (10 mmol/L) or control media for 48 hours in culture. Read More

    Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):69-73
    Department of Ophthalmology, School of Medicine, Cukurova University, Adana, Turkey.
    Purpose:: We aimed to compare the retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and the choroid thickness between patients with Behcet disease and healthy subjects by using spectral domain optical coherence tomography (SD-OCT).

    Methods:: Ninety eyes of 45 healthy subjects and 104 eyes of 52 patients with Behcet disease were included in this study. Rheumatoid factor and C-reactive protein levels were measured by blood testing in the patients. Read More

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