1,707 results match your criteria Arquivos Brasileiros de Endocrinologia e Metabologia[Journal]


PTPN2 gene polymorphisms are associated with type 1 diabetes mellitus in Brazilian subjects?

Arq Bras Endocrinol Metabol 2014 Dec;58(9):980-1

Laboratory of Human Pancreatic Islet Biology, Endocrine Division, Hospital de Clínicas de Porto Alegre, Brazil.

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December 2014

PTPN2, a potential therapeutic target for type 1 diabetes?

Arq Bras Endocrinol Metabol 2014 Dec;58(9):978-9

Department of Health Evaluation, Shanghai Pudong Institute for Health Development, Shanghai, PR China.

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December 2014

Response to the letter: Red cell distribution width in subclinical hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):976-7

Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Eulji University Hospital, Daejeon, Republic of Korea.

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December 2014

Red cell distribution width in subclinical hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):974-5

Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.

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December 2014

Response to the letter: Angiotensin-II induced insulin resistance.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):972-3

Endocrinology Unit, University Hospital of Los Andes, Mérida, Venezuela.

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December 2014

Angiotensin-II induced insulin resistance.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):970-1

Department of Endocrinology and Metabolism, Ankara Numune Research and Training Hospital, Ankara, Turkey.

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December 2014

[Giant metastasis of thyroid papillar carcinoma].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):967-9

Departamento de Cirurgia de Cabeça e Pescoço, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

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December 2014

A case of thyroid hormone resistance: a rare mutation.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):962-6

Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal.

Reduced sensitivity to thyroid hormones (RSTH) is a rare disease that affects about 3,000 individuals, belonging to about 1,000 families. It results from reduced intracellular action of thyroid hormones (TH) genetically determined and manifests as persistent hyperthyroxinemia with non-suppressed thyroid-stimulating hormone (TSH). We describe a 67-years old, Caucasian woman, with past history of subtotal thyroidectomy due to diffuse goiter, who presents with a recurrence of goiter. Read More

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December 2014

Large thyroid cyst in a patient with congenital hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):958-61

Department of Nuclear Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Thyroid hormone biosynthetic defects are rare causes of congenital hypothyroidism. Although, initial presentations are usually diffuse goiter and hypothyroidism, subsequently they may develop thyroid nodules and or thyroid cancer. We describe a case of hypothyroidism due to dyshormonogenesis whose one of the previously solid nodules degenerates into a large cyst. Read More

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December 2014

Marrow hypoplasia: a rare complication of untreated Grave's disease.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):953-7

Institute of Diabetes and Endocrinology Luiz Capriglione, Rio de Janeiro, RJ, Brazil.

Atypical presentation forms of hyperthyroidism are always a challenge to the clinician. We present a female patient with the typical symptoms of thyrotoxicosis, without any thionamides treatment before, associated with pancytopenia, which recovered after euthyroidism state was achieved. Although the major cases of pancytopenia in Grave's disease are seen as a complication of antithyroid drugs (thioamides), in this case report the alteration in blood tests was associated with untreated hyperthyroidism. Read More

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December 2014

[Reduction of functional mobility and cognitive capacity in type 2 diabetes mellitus].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):946-52

LIM-18, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Objectives: The aim of the present study was to evaluate the functional mobility and its relationship to cognitive ability in patients with type 2 diabetes (T2DM), age between 50 and 65 years and under 10 years of diagnosis.

Materials And Methods: An observational, analytical and cross-sectional study, involving no diabetic and type 2 diabetic individuals with inadequate glycemic control, selected by convenience sampling. In both groups, were administered structured questionnaire and cognitive assessment with Mini-Mental State Examination (MMSE) and the clock drawing test (CDT), besides assessment of functional mobility by the Timed Up & Go (TUG). Read More

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December 2014

Evaluation of cytopathological findings in thyroid nodules with macrocalcification: macrocalcification is not innocent as it seems.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):939-45

Department of Endocrinology and Metabolism, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey.

Objective: Microcalcification is strongly correlated with papillary thyroid cancer. It is not clear whether macrocalcification is associated with malignancy. In this study, we aimed to assess the result of fine needle aspiration biopsies (FNAB) of thyroid nodules with macrocalcifications. Read More

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December 2014

Thyroid nodules and thyroid cancer in Graves' disease.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):933-8

Department of Endocrinology and Metabolism, Yıldırım Beyazıt University, Ankara, Turkey.

Objective: The frequency of thyroid nodules accompanying Graves' disease and the risk of thyroid cancer in presence of accompanying nodules are controversial. The aim of this study was to evaluate the frequency of thyroid nodules and the risk of thyroid cancer in patients operated because of graves' disease.

Subjects And Methods: Five hundred and twenty-six patients in whom thyroidectomy was performed because of Graves' disease between 2006 and 2013 were evaluated retrospectively. Read More

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December 2014

The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):926-32

Medical University of Sofia, University Hospital of Endocrinology, Sofia, Bulgaria.

Objective: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects.

Materials And Methods: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14. Read More

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December 2014

The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):918-25

Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Objective: The aim of this study was to investigate the association between the rs7903146 (C/T) polymorphism in the TCF7L2 gene and type 2 diabetes mellitus, in a Southern-Brazilian population.

Materials And Methods: The TCF7L2 rs7903146 polymorphism was genotyped in 953 type 2 diabetic patients and 535 non-diabetic subjects. All subjects were white. Read More

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December 2014

Evaluation of percutaneous ethanol injections in benign thyroid nodules.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):912-7

Department of Endocrinology and Metabolism, Hospital de Clinicas, Federal University of Paraná, Curitiba, PR, Brazil.

Objective: The objective of this study was to evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules.

Subjects And Methods: We evaluated 120 patients with benign thyroid nodules. Patients underwent evaluation of serum TSH and free T4, cervical ultrasound, and thyroid scintigraphy (in those with suppressed TSH levels). Read More

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December 2014

An international survey of screening and management of hypothyroidism during pregnancy in Latin America.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):906-11

Department of Biorregulation, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil.

Objective: To determine how endocrinologists in Latin America deal with clinical case scenarios related to hypothyroidism and pregnancy.

Materials And Methods: In January 2013, we sent an electronic questionnaire on current practice relating to management of hypothyroidism in pregnancy to 856 members of the Latin American Thyroid Society (LATS) who manage pregnant patients with thyroid disease. Subsequently, we have analyzed responses from physician members. Read More

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December 2014

[Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus].

Arq Bras Endocrinol Metabol 2014 Dec;58(9):900-5

Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.

Objective: To assess the association of the G54D (rs1800450) polymorphism of the gene MBL2 in the gestational diabetes mellitus with the need for additional treatment and the occurrence of large newborns for the gestational age.

Subjects And Methods: One hundred and five patients recruited in Joinville--Brazil were evaluated between November 2010 and October 2012. Pregnant women were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. Read More

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December 2014

Brown adipose tissue: what have we learned since its recent identification in human adults.

Arq Bras Endocrinol Metabol 2014 Dec;58(9):889-99

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Brown adipose tissue, an essential organ for thermoregulation in small and hibernating mammals due to its mitochondrial uncoupling capacity, was until recently considered to be present in humans only in newborns. The identification of brown adipose tissue in adult humans since the development and use of positron emission tomography marked with 18-fluorodeoxyglucose (PET-FDG) has raised a series of doubts and questions about its real importance in our metabolism. In this review, we will discuss what we have learnt since its identification in humans as well as both new and old concepts, some of which have been marginalized for decades, such as diet-induced thermogenesis. Read More

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December 2014

Bariatric surgery--an update for the endocrinologist.

Authors:
Marcio C Mancini

Arq Bras Endocrinol Metabol 2014 Dec;58(9):875-88

Endocrinology & Metabolism Department, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Obesity is a major public health problem, is associated with increased rates of mortality risk and of developing several comorbidities, and lessens life expectancy. Bariatric surgery is the most effective treatment for morbidly obese patients, reducing risk of developing new comorbidities, health care utilization and mortality. The establishment of centers of excellence with interdisciplinary staff in bariatric surgery has been reducing operative mortality in the course of time, improving surgical safety and quality. Read More

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December 2014

Images in endocrinology: multinodular goitre.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):873-4. Epub 2014 Nov 1.

Department of Diagnostic Sciences, Division of Radiology and Interventional Radiology, San Carlo Borromeo Hospital.

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November 2014

Breast cancer metastasis to the pituitary gland.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):869-72. Epub 2014 Nov 1.

Department of Endocrinology, Hospital Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil.

Metastatic tumors to the pituitary gland are an unusual complication typically seen in elderly patients with diffuse malignant disease. Breast and lung are the commonest sites of the primary tumor. Prognosis of patients with breast cancer metastasis is poor and depends on the primary neoplastic extension. Read More

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November 2014

IgG4-related Hashimoto's thyroiditis--a new variant of a well known disease.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):862-8. Epub 2014 Nov 1.

Department of Endocrinology and Diabetology, Hospital Garcia de Orta, Almada, Portugal.

Hashimoto's thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered a heterogeneous disease. IgG4-related HT is a new subtype characterized by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic IgG4-related disease. Read More

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November 2014

[Clinical heterogeneity of atypical fractures during prolonged use of bisphosphonates--risk factors and bone turnover markers].

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):855-61. Epub 2014 Nov 1.

Departamento de Clínica Médica do Hospital de Clínicas, UFPR, Curitiba, PR, Brasil.

We describe four cases of atypical femoral fractures treated at the Department of Endocrinology, Hospital de Clínicas, Federal University of Paraná (SEMPR) which, although characteristic of this type of fracture, presented clinical peculiarities that should be considered and serve as a warning in these patients, such as: late diagnosis with maintenance of bisphosphonates; absence of co-morbidities with excellent result; failure of fracture healing; use of anabolic medication after the fracture and the use of bone turnover markers at the follow up. Read More

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November 2014

Papillary thyroid cancer case masked by subacute thyroiditis.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):851-4. Epub 2014 Nov 1.

Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey.

Subacute thyroiditis (SAT) association with thyroid carcinoma has been rarely reported in the literature. We present a patient with SAT and papillary thyroid cancer that was suspected by ultrasonographic evaluation (US) following SAT treatment. A fifty-four-year old female patient referred to our department due to tachycardia, jitteriness and pain in cervical region for the past one month. Read More

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November 2014

Determination of cortisol and cortisone in human saliva by a liquid chromatography-tandem mass spectrometry method.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):844-50. Epub 2014 Nov 1.

Steroid Laboratories, Grupo Fleury, São Paulo, SP, Brazil.

Objective: Salivary cortisol measurement plays an important role in the evaluation of adrenal function. Its high correlation with free serum cortisol, the easy of sampling and the limited presence of interfering steroids, generated multiple recent studies of its application, in special in the screening of adrenal hyperfunction. In this paper we present our experience in the development of a high pressure liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for salivary cortisol and cortisone measurement. Read More

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November 2014

[Old and new anthropometric indices as insulin resistance predictors in adolescents].

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):838-43. Epub 2014 Nov 1.

Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil.

Objective: Despite the importance of insulin resistance (IR) on chronic diseases development, its diagnosis remains invasive. Thus, it's necessary to develop alternative methods to predict IR on clinical practice, and the anthropometric indices are a good alternative to it. Given that, this study's purpose is to evaluate these indices behavior in relation to HOMA-IR (Homeostasis Model Assessment of Insulin Resistance). Read More

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November 2014

Short-term effects of triiodothyronine on thyroid hormone receptor alpha by PI3K pathway in adipocytes, 3T3-L1.

Arq Bras Endocrinol Metabol 2014 Nov;58(8):833-7

Department of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, Botucatu, SP, Brazil.

Objective: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRα) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.

Materials And Methods: It was examined the involvement of PI3K pathway in mediating T3 effects by treating 3T3-L1 adipocytes with physiological (P=10nM) or supraphysiological (SI =100 nM) T3 doses during one hour (short time), in the absence or the presence of PI3K inhibitor (LY294002). The absence of any treatment was considered the control group (C). Read More

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November 2014

Mutation screening of the sodium iodide symporter gene in a cohort of 105 China patients with congenital hypothyroidism.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):828-32. Epub 2014 Nov 1.

Department of Genetic Metabolism, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region.

Objective: Dyshormonogenetic congenital hypothyroidism (CH) was reported to be associated with a mutation in the sodium iodide symporter (NIS) gene. The present study was undertaken in the Guangxi Zhuang Autonomous Region of China, to determine the nature and frequency of NIS gene mutations among patients with CH due to dyshormonogenesis.

Subjects And Methods: Blood samples were collected from 105 dyshormonogenetic CH patients in Guangxi Zhuang Autonomous Region, China, and genomic DNA was extracted from peripheral blood leukocytes. Read More

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November 2014

Thyroid volume in patients with glucose metabolism disorders.

Arq Bras Endocrinol Metabol 2014 Nov 1;58(8):824-7. Epub 2014 Nov 1.

Department of Endocrinology and Metabolism, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objective: Thyroid volume and the prevalence of thyroid nodules are higher in patients with insulin resistance. A relationship between thyroid volume and glucose metabolism disorders (GMD) has not as yet been clarified. The present retrospective study aimed to investigate the association between GMD and thyroid volume. Read More

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November 2014