9,713 results match your criteria Arkhiv patologii[Journal]


[The anniversary of the European Society of Pathology. The Society's activity in the twentieth century].

Authors:
N M Anichkov

Arkh Patol 2019 ;81(2):66-72

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

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http://dx.doi.org/10.17116/patol20198102166DOI Listing
January 2019

[Histological differential diagnosis of granulomatous lung diseases (Part II)].

Arkh Patol 2019 ;81(2):59-65

Pulmonology Research Institute, Federal Biomedical Agency of Russia, Moscow, Russia; A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia; Research Institute of Human Morphology, Moscow, Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.

Granulomatous diseases are a heterogeneous group of the diseases of different etiology, which are manifested by a variety of clinical syndromes and variants of tissue changes, by non-uniform sensitivity to therapy and by the predominance of the common dominant histologic sign - the presence of granulomas that determine the clinical and morphological essence of each disease. Granuloma is a chronic inflammatory response, which involves macrophages and other inflammatory cells. After antigen exposure, the activation of T lymphocytes, macrophages, epithelioid cells, and multinucleated giant cells results in granuloma formation. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2019/2/dow
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http://dx.doi.org/10.17116/patol20198102159DOI Listing
January 2019
1 Read

[Carcinoma with unknown primary site: Morphological diagnosis].

Authors:
A S Zhuravlev

Arkh Patol 2019 ;81(2):51-58

OOO 'YUNIM' Pathology Laboratory, Moscow, Russia.

Carcinoma with unknown primary site (CUPs) is a group of malignant tumors, the first manifestation of which is metastatic dissemination. A primary tumor cannot be usually identified by a physical examination of patients with CUPs; a postmortem study plays a significant role in the diagnosis of the origin of metastasis. The paper gives the data available in the literature data on the postmortem diagnosis of CUPs and considers the morphological characteristics of metastases and the possibilities of immunohistochemical diagnosis and a molecular genetic method in the search for a primary focus. Read More

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http://dx.doi.org/10.17116/patol20198102151DOI Listing
January 2019

[The personified accounting and intra-team distribution of the workload of pathologists, by using a procedure for their work quota setting].

Arkh Patol 2019 ;81(2):47-50

Irkutsk State Medical University, Ministry of Health of Russia, Irkutsk, Russia.

The paper considers approaches to applying the methods for setting work quotas in pathologists for the personified accounting and intra-team distribution of their workload. These approaches include an algorithm and all necessary formulas for the calculation of the relevant indicators that make it possible to use the methods for work quota setting. The essence of the proposed approaches is demonstrated with a specific example. Read More

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http://dx.doi.org/10.17116/patol20198102147DOI Listing
January 2019

[Solitary ganglioneuroma of the oropharynx].

Arkh Patol 2019 ;81(2):43-46

Research and Clinical Centre for Otorhinolaryngology, Federal Biomedical Agency of Russia, Moscow, Russia.

Mucosal neuromas, or ganglioneuromas, attract attention as a frequent component of multiple endocrine neoplasia (MEN) syndrome type 2B. The paper describes a clinical and morphological case of solitary oropharyngeal ganglioneuroma in a 60-year-old man, whose observation has not revealed its apparent association with the MEN syndrome. Read More

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http://dx.doi.org/10.17116/patol20198102143DOI Listing
January 2019

[Central nervous system atypical teratoid/rhabdoid tumor without loss of nuclear expression of INI1].

Arkh Patol 2019 ;81(2):36-42

Acad. N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of Russia, Moscow, Russia.

The paper describes a clinical case of atypical teratoid/rhabdoid tumor with preserved INI1 expression and SMARCA4 gene mutations in an 8-month-old girl. Genome-wide DNA methylation, hierarchical clustering, and next-generation sequencing were used to make a tumor diagnosis. However, BRG1 immunohistochemical examination may be recommended in the routine practice of diagnosis and study of childhood CNS malignant tumors. Read More

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http://dx.doi.org/10.17116/patol20198102136DOI Listing
January 2019
1 Read

[Prevalence of hepatitis B and C viral infection according to the data on fetal outcomes in Moscow in 2015-2017].

Arkh Patol 2019 ;81(2):29-35

Department of Pathological Anatomy, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.

Objective: To elucidate the prevalence of hepatitis B and C viral infection among the people who died in Moscow in 2015-2017, by studying the primary medical records of a representative sample of fatal outcomes, followed by the mathematical extrapolation of the data obtained to the total number of all deaths.

Material And Methods: The 2015-2017 primary medical documentations from 8 therapeutic-and-preventive establishments with morbid anatomy units in the administrative districts and from 2 infectious diseases hospitals of the Moscow Healthcare Department were studied. The sample of those who died was 11. Read More

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http://dx.doi.org/10.17116/patol20198102129DOI Listing
January 2019

[The nasal mucosa and outcomes of dacryocystorhinostomy].

Arkh Patol 2019 ;81(2):24-28

Research Institute of Eye Diseases, Moscow, Russia.

Objective: To investigate the impact of the nasal mucosa on the outcomes of dacryocystorhinostomy on the basis of morphologic findings.

Material And Methods: The investigation enrolled 73 patients who had undergone endonasal endoscopic dacryocystorhinostomy. Nasal mucosal biopsies were intraoperatively taken from all the patients. Read More

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http://dx.doi.org/10.17116/patol20198102124DOI Listing
January 2019

[Expression of the antiapoptotic protein survinin and its gene in primary breast carcinoma].

Arkh Patol 2019 ;81(2):18-23

Educational Establishment 'Vitebsk State Order of Peoples' Friendship Medical University', Vitebsk, Republic of Belarus.

Aim: To study the expression of the anti-apoptotic survivin protein, as well as the expression of the BIRC5 gene of its encoding primary breast carcinoma as a potential procnostic and predictive marker.

Material And Methods: With the help of immunohistochemistry (IHC), as well as polymerase chain reaction in real time (real-time PCR), 67 samples (biopsy) of the primary breast carcinoma were studied for the presence of expression of the survivin protein and the gene of its encoding BIRC5.

Results: Expression of survivin was determined in 47 mammary carcinoma samples, which was 70. Read More

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http://dx.doi.org/10.17116/patol20198102118DOI Listing
January 2019

[Comparative assessment of the expression of Muc 2, Muc 5AC, and Muc 6 in serrated neoplasms of the colon].

Arkh Patol 2019 ;81(2):10-17

Research Institute of Human Morphology, Moscow, Russia.

In the course of the serrated pathway of carcinogenesis, there are changes in the expression of mucins with a characteristic immunophenotypic sign, such as a late loss of intestinal differentiation and an increase in gastric differentiation.

Objective: To comparatively assess the expression of Muc 2, Muc 5AC, and Muc 6 in hyperplastic polyps (HPs), sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) of the colon for determination of their role in differential diagnosis.

Material And Methods: Sixty-five serrated masses from 52 patients were examined. Read More

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http://dx.doi.org/10.17116/patol20198102110DOI Listing
January 2019
1 Read

[PD-L1 status in breast cancer].

Arkh Patol 2019 ;81(2):3-9

Regional Clinical Oncology Dispensary, Ryazan, Russia.

Objective: To investigate the expression of PD-L1 in triple-negative and luminal B, HER2-negative breast carcinoma and to assess the association of the tumor PD-L1 status with the prognosis of the disease.

Subject And Methods: The PD-L1-status of primary tumor was studied in 72 patients with breast cancer, by using an immunohistochemical method.

Results: Differences were found in the incidence of carcinomas with PD-L1 expression in tumor cells depending on the molecular genetic type: there was a positive PD-L1 status in luminal B, HER2-negative tumors in 4 (14. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2019/2/dow
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http://dx.doi.org/10.17116/patol2019810213DOI Listing
January 2019
1 Read

[First Research and Practical Conference of Pathologists of the Ural Federal District].

Arkh Patol 2019;81(1):79-80

South Ural Federal State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia.

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http://dx.doi.org/10.17116/patol20198101179DOI Listing
January 2019

[Morphofunctional features of non-functioning pituitary adenomas].

Arkh Patol 2019;81(1):71-78

National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Non-functioning pituitary adenomas (NFPAs) account for about 30% of all pituitary tumors. NFPAs are characterized by the lack of secretory potential or its weak expression insufficient for determination of the blood level of adenohypophyseal tropic hormones and for development of a specific clinical picture. Morphologically, NFPAs are a heterogeneous group of tumors, the classification of which was previously based only on immunoreactivity for pituitary tropic hormones. Read More

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http://dx.doi.org/10.17116/patol20198101171DOI Listing
January 2019

[Histological differential diagnosis of granulomatous lung diseases (part I)].

Arkh Patol 2019;81(1):65-70

Pulmonology Research Institute, Federal Biomedical Agency of Russia, Moscow, Russia; A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia; Research Institute of Human Morphology, Moscow, Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia.

Granulomatous diseases are a heterogeneous group of the diseases of different etiology, which are manifested by a variety of clinical syndromes and variants of tissue changes, by non-uniform sensitivity to therapy, and by the predominance of the common dominant histologic sign - the presence of granulomas that determine the clinical and morphological essence of each disease. Granuloma is a chronic inflammatory response, which involves macrophages and other inflammatory cells. After exposure to an antigen, T-lymphocytes, macrophages, epithelioid cells, and multinucleated giant cells are activated, resulting in the formation of granulomas. Read More

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http://dx.doi.org/10.17116/patol20198101165DOI Listing
January 2019
4 Reads

[Diagnosis of isolated cardiac sarcoidosis].

Arkh Patol 2019;81(1):57-64

Belarusian State Medical University, Minsk, Republic of Belarus.

Heart involvement in sarcoidosis is diagnosed in vivo in 5-7%, at autopsy in 25% of cases as a manifestation of a systemic process and an isolated one. Difficulties in the diagnosis of isolated sarcoidosis are due to the absence of known causes of the disease and to the lack of specificity of clinical manifestations. The main symptoms include cardiac conduction and rhythm disturbances, cardiomyopathy with the development of heart failure, as well as pericardial involvement. Read More

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http://dx.doi.org/10.17116/patol20198101157DOI Listing
January 2019
4 Reads

[Role of adipose tissue in the development and progression of colorectal cancer].

Arkh Patol 2019;81(1):52-56

Smolensk State Medical University, Ministry of Health of Russia, Smolensk, Russia; Smolensk Regional Institute of Pathology, Smolensk, Russia.

The paper gives the current data available in the literature on the relationship and pathogenetic mechanisms of influence of adipose tissue on colorectal carcinogenesis. It considers the aspects of changes in adipose tissue and microenvironment of the tumor itself, including those under the influence of biologically active substances secreted by adipocytes; differences in subcutaneous and visceral fat and their importance in the development and progression of colorectal cancer (CRC), as well as the role of adipose tissue-derived stem cells. Understanding these mechanisms for adipose tissue influence on CRC will assist not only in preventing this disease, but also in searching for new therapeutic targets. Read More

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http://dx.doi.org/10.17116/patol20198101152DOI Listing
January 2019

[Histopatological and molecular genetic characteristics of clinically aggressive variants of papillary thyroid carcinoma].

Arkh Patol 2019;81(1):46-51

V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; National Research Technological University 'Moscow Institute of Steel and Alloys', Moscow, Russia.

Papillary carcinoma is the most commonly diagnosed form of well-differentiated thyroid cancer that is generally characterized by a favorable prognosis. However, a number of relatively rare variants of this tumor, such as papillary carcinoma of high cells, papillary carcinoma of columnar cells, a diffuse sclerosing variant and recently described cancer of shoe nail cell type, are characterized by a less favorable clinical course, a high frequency of distant metastasis, and relatively low overall and relapse-free survival rates. In this connection, it is important to recognize these options at the stage of a primary morphological study. Read More

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http://dx.doi.org/10.17116/patol20198101146DOI Listing
January 2019

[Application of tissue-marking dyes for pathologic examination of surgical and autopsy specimens].

Arkh Patol 2019;81(1):40-45

Pathoanatomical Department of Clinical Molecular Morphology, E.E. Eichwald Clinic, I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Objective: To assess the applicability of imported tissue-marking dyes and the samples of experimental dyes and decorative acrylic paints to mark the resection margins of a surgical specimen.

Material And Methods: Three sets of tissue-marking dyes: 2 imported sets and 1 experimental set, each containing red, orange, yellow, green, blue, purple, and black dyes, and a set of decorative acrylic paints containing black, blue, light blue, green, yellow, ocher, orange, magenta, and purple dyes. The experimental dyes and imported ones were used to mark tonsillar fragments obtained at tonsillectomy. Read More

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http://dx.doi.org/10.17116/patol20198101140DOI Listing
January 2019
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[Value of liver biopsy in the diagnosis of hereditary hemochromatosis].

Arkh Patol 2019;81(1):35-39

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper gives an update on the pathogenesis and main clinical manifestations of primary (hereditary) hemochromatosis and its diagnostic methods. It emphasizes the importance of genetic research in the diagnosis of the disease. Its clinical manifestations are associated with iron deposition in organs, such as the liver, pancreas, joints, skin, and heart. Read More

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http://dx.doi.org/10.17116/patol20198101135DOI Listing
January 2019
3 Reads

[Trichilemmal carcinoma in a patient with squamous cell skin cancer].

Arkh Patol 2019;81(1):31-34

State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of Russia, Moscow, Russia.

Trichilemmal carcinoma is a rare skin tumor that mainly occurs in the elderly (mean age, 71 years) and is localized in the repeatedly sun-exposed areas, most commonly on the face, scalp, neck, and dorsa of the hands. Its differential diagnosis is made with squamous cell skin cancer, clear-cell porocarcinoma, hidradenocarcinoma, and melanoma. The prognosis of trichilemmal carcinoma is most favorable than that of other skin tumors during radical removal. Read More

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http://dx.doi.org/10.17116/patol20198101131DOI Listing
January 2019
4 Reads

[The expression of apoptosis and autophagy markers in transplantable rat kidney cancer with the administration of flavonoid-containing hedge hyssop ( L.) extract].

Arkh Patol 2019;81(1):24-30

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia.

Objective: To establish the mechanisms of pathomorphism of transplantable kidney cancer in rats that used flavonoid-containing hedge hyssop (Gratiola officinalis L.) extract in an in vivo experiments.

Material And Methods: The experiment was carried out on 30 male Wistar rats with transplantable kidney cancer PA. Read More

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http://dx.doi.org/10.17116/patol20198101124DOI Listing
January 2019

[Features of filiform papillary lesion of the tongue and its mucosal microflora biofilm in patients with gastroesophageal reflux disease].

Arkh Patol 2019;81(1):18-23

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.

Objective: To identify filiform papillary lesions, localization changes, and the composition of the microflora of the dorsal lingual surface in patients with gastroesophageal reflux disease (GERD).

Material And Methods: Dorsal lingual surface biopsy specimens were investigated in 7 patients with GERD (3 men, 4 women) and in 6 individuals without digestive diseases (3 men, 3 women). The diagnosis of GERD was based on a set of clinical data, daily pH-metry, EGDS, and the specialized GerdQ questionnaire. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2019/1/dow
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http://dx.doi.org/10.17116/patol20198101118DOI Listing
January 2019
6 Reads

[Current possibilities of the differential diagnosis of plaque parapsoriasis and the early stages of mycosis fungoides].

Arkh Patol 2019;81(1):9-17

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Mycosis fungoides (MF) is the most common primary cutaneous epidermotropic T-cell lymphoma (80%). The accurate diagnosis of MF confirmed only by clinical, histological and immunohistochemical signs amounts to 50-75%.

Objective: To investigate genetic markers (FOXP3, STAT4, IL-12B) for the early diagnosis of MF, to estimate the informative value of used diagnostic techniques (histology, immunophenotyping), and to determine clonality by the T-cell receptor γ-chain genes. Read More

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http://dx.doi.org/10.17116/patol2019810119DOI Listing
January 2019
3 Reads

[Ultrastructure of epidermocytes in true pemphigus acantholysis].

Arkh Patol 2019;81(1):3-8

Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.

Objective: To investigate the ultrastructure of epidermocytes in skin biopsy specimens, by taking into account an update on the pathomorphogenesis of true pemphigus acantholysis.

Material And Methods: Affected skin biopsy specimens from 4 patients with Pemphigus vulgaris (a mixed mucosal-epidermal variant) and from 1 patient with P. foliaceus at the onset of the disease in the absence of therapy were examined by light microscopy of semifine sections and by transmission electron microscopy. Read More

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http://dx.doi.org/10.17116/patol2019810113DOI Listing
January 2019
1 Read

[Legal, clinical and statistical problems in pathologists activity].

Authors:
E F Lushnikov

Arkh Patol 2018;80(6):78-81

A.F.Tsyb Medical Radiology Research Centre, Branch, National Medical Radiology Reseach Centre, Ministry of Health of Russia, Obninsk, Russia.

The article discusses important problems of practice and science: rights of a pathologists, clinico-anatomical comparisons and causes of death. Read More

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http://dx.doi.org/10.17116/patol20188006178DOI Listing
January 2018

[The decisive importance of constitutional interferons in human and animal ontogenesis].

Arkh Patol 2018;80(6):68-72

Research Institute of Human Morphology, Moscow, Russia.

Biomedical publications contain little information on the constitutional (endogenous) interferons (IFNs) produced by different cells without prior exposure to viruses and oncogenic factors. Literature analysis has provided a generalized concept that these interferons play different functional roles according to ontogenetic stages. The maximum production of high-molecular- weight immature forms of IFNα/β was detected in the embryos of mice, Syrian hamsters, and humans and in the syncytiotrophoblast of placental villi. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/6/dow
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http://dx.doi.org/10.17116/patol20188006168DOI Listing
January 2018
4 Reads

[Role of biological heterogeneity in recurrent and metastatic breast cancer].

Arkh Patol 2018;80(6):62-67

Russian Medical Academy of Continuing Professional Education, Moscow, Russia.

Breast cancer (BC) is a heterogeneous tumor, the biological characteristics of which vary with its growth and progression. Information on key tumor receptors (ER, PR, HER2, and Ki-67) is the basis for individualizing the diagnostic and treatment algorithm at all BC stages; however, the feasibility of biopsy of distant metastases and the re-testing of the biological subtype of BC in its suspected progression are being actively discussed in clinical practice. This review presents an update on the features of metastasis in different biological BC subtypes and assesses the clinical and prognostic role of biopsy of distant metastases in the lung, bones, liver, and brain. Read More

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http://dx.doi.org/10.17116/patol20188006162DOI Listing
January 2018
1 Read

[Neurogenesis in the adult human brain: morphological aspects].

Arkh Patol 2018;80(6):55-61

V.A. Almazov National Medical Research Center, Ministry of Health of Russia, Saint Petersburg, Russia; Saint Petersburg State University, Saint Petersburg, Russia.

The high prevalence of diseases leading to brain injury disability makes it extremely relevant to study the various mechanisms of neurorehabilitation, among which neurogenesis has recently received a great attention. Over the past 20 years, there has been ample evidence for neurogenesis in the adult animal brain. Despite the fact that the prenatal development of the human brain has been thoroughly studied, the number of works on the process by which new neurons form in the adult human brain is not so large. Read More

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http://dx.doi.org/10.17116/patol20188006155DOI Listing
January 2018

[Primary uterine cervix melanoma].

Arkh Patol 2018;80(6):50-54

Belgorod Pathological Anatomy Bureau, Belgorod, Russia.

The purpose of this paper is to present a rare clinical case of primary uterine cervix melanoma. Clinical data and histological specimens were a material for this investigation. The paper describes a case of primary uterine cervix melanoma in a 47-year-old patient who visited a gynecologist for contact bleeding from the genital tract. Read More

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http://dx.doi.org/10.17116/patol20188006150DOI Listing
January 2018
1 Read

[A revised 4 edition WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, 2017: myeloid neoplasms].

Authors:
A M Kovrigina

Arkh Patol 2018;80(6):43-49

National Medical Research Center for Hematology, Ministry of Health of Russia, Moscow, Russia.

The paper presents new molecular data, the principles of the classification of myeloid neoplasms, and criteria for their diagnosis according to the new edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, 2017. Current concepts of clonal hematopoiesis and models of clonal evolution are presented to characterize the common features of the molecular pathogenesis of myeloid neoplasms. There are new data and general principles of diagnosis of myeloid neoplasms: Ph-negative myeloproliferative diseases, myelodysplastic syndromes, myeloid/lymphoid neoplasms with eosinophilia and rearrangements of PDGFRA, PDGFRB, FGFR1, and PCM1-JAK2, diseases from the group of myelodysplastic/myeloproliferative diseases. Read More

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http://dx.doi.org/10.17116/patol20188006143DOI Listing
January 2018
1 Read

[Investigation of markers for myocardial remodeling during experimental hypobaric hypoxia in the correction with cytoflavin].

Arkh Patol 2018;80(6):35-42

S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.

The limited possibilities of determining myocardial morphological changes in the clinic make it necessary to investigate the effects of intermittent hypobaric hypoxia in an experiment setting.

Objective: To reveal the peculiarities of changes in the markers of myocardial remodeling in experimental hypobaric hypoxia.

Material And Methods: The investigation was conducted on 26 mature male Wistar rats weighing 220-310 g, which were divided into 3 groups: 1) 6 intact animals; 2) 10 rats that were exposed to 30-day simulated hypobaric hypoxia without correction; 3) 10 rats that were given once-daily intraperitoneal injections of cytoflavin solution at a rate of 0. Read More

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http://dx.doi.org/10.17116/patol20188006135DOI Listing
January 2018

[Effect of human brain extracts on cultured neuroblastoma cells].

Arkh Patol 2018;80(6):29-34

Laboratory of Cell Biology and Virology, Institute of Molecular Biology, National Academy of the Republic of Armenia, Yerevan, Republic of Armenia.

Objective: To identify the effect of brain extracts from people of different age groups on possible changes in cell physiology and behavior in vitro.

Material And Methods: Human frontal cortical segments were obtained 12-24 hours after autopsy. Brain tissue extract was taken from young people who died at age of 22. Read More

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http://dx.doi.org/10.17116/patol20188006129DOI Listing
January 2018
1 Read

[Gelatinases A and B and their endogenous regulators in the corpus uteri in squamous cell cervical carcinoma].

Arkh Patol 2018;80(6):22-28

V.N. Orekhovich Institute of Biomedical Chemistry, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the expression of gelatinases A and B (matrix metalloproteinases (MMP 2 and MMP 9) and endogenous regulators of their activity, such as a tissue inhibitor of MMP - TIMP-2 and a Pro-MMP-9 activator - urokinase-type plasminogen activator (uPA) as factors of corpus uteri invasion in squamous cell cervical carcinoma (SCCC).

Material And Methods: The surgical material obtained after hysterectomy in patients diagnosed with SCCC was examined. RT-PCR, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay were used. Read More

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http://dx.doi.org/10.17116/patol20188006122DOI Listing
January 2018
1 Read

[The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis].

Arkh Patol 2018;80(6):14-21

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia; Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in different forms of adenomyosis.

Material And Methods: Fifty uteri removed for diffuse adenomyosis and for adenomyomas were examined in reproductive-aged (n=25) and premenopausal (n=25) women. A comparison group included 20 uteri removed for intramural and subserosal fibroids in reproductive-aged and premenopausal women. Read More

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http://dx.doi.org/10.17116/patol20188006114DOI Listing
January 2018

[Ultrastructural features of cardiomyocytes in infants with tetralogy of Fallot in the first year of life].

Arkh Patol 2018;80(6):3-13

A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russia, Moscow, Russia.

Objective: To analyze cardiomyocyte (CMC) ultrastructural changes in the right ventricle outflow tract (RVOT) of infants with tetralogy of Fallot (TF) in the first years of life and to compare the findings with clinical parameters in these patients.

Material And Methods: Intraoperative RVOT myocardial biopsy specimens obtained from 51 patients aged 3-33 months with TF during radical correction of defect were investigated. CMC diameter and length were measured using the semithin myocardial sections stained with periodic acid-Schiff. Read More

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http://dx.doi.org/10.17116/patol2018800613DOI Listing
January 2018
2 Reads

[Chronic diseases, precancer, and cancer of the lung, which are associated with pathology of the club cells of respiratory and terminal bronchioles].

Arkh Patol 2018;80(5):63-68

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The review of the literature deals with the participation of Clara cells now called club cells (CCs) of the epithelium in the respiratory and terminal bronchioles in the pathogenesis and morphogenesis of chronic inflammatory diseases, precancer, and cancer of the lung, which develop in the respiratory segments. The review summarizes data on the histophysiology of CCs and their participation in the pathogenesis and morphogenesis of chronic interstitial lung diseases, pneumoconiosis, chronic obstructive diseases, adenomatosis, and adenocarcinoma of the lung. In this area, there is a bronchioloalveolar junction area (BAJA), one of the most important stem cell niches. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/5/dow
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http://dx.doi.org/10.17116/patol20188005163DOI Listing
March 2019
13 Reads

[Autoimmune/inflammatory syndrome induced by adjuvants].

Arkh Patol 2018;80(5):56-62

N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

The development of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is associated with the hyperergic reaction of the human immune system. The development of autoimmune inflammation is preceded by contact with internal or external trigger factors (adjuvants) of immune disorders. ASIA is associated with an individual genetic predisposition that is probably associated with the carriage of HLA-DRB1*01 or HLA-DRB4. Read More

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http://dx.doi.org/10.17116/patol20188005156DOI Listing
March 2019
4 Reads

[The disciplines of choice in the teaching of pathoanatomy].

Authors:
B B Saltykov

Arkh Patol 2018;80(5):54-55

Academician A.I. Strukov Department of Pathoanatomy, I.M. Sechenov First Moscow State Medical University, Ministery of Health of Russia, Moscow, Russia.

The changes caused by scientific and technological progress have required that the pedagogical process should be substantially restructured. This is solved to a large extent by the discipline of choice (electives). Free choice and contact with leading experts on the topic of interest to a particular student increase the quality of teaching and the level of its theoretical and practical training. Read More

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http://dx.doi.org/10.17116/patol20188005154DOI Listing

[A method for preparation of an endothelial cell monolayer sample from the blood vessel intima].

Authors:
N A Solovyeva

Arkh Patol 2018;80(5):51-53

Department of Pathoanatomy, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper describes the procedure to prepare endothelial cell monolayer samples from the vascular intima, which is suitable for studying various morphological processes. To obtain high-quality multicellular specimens, it is recommended to preliminarily remove excess tissue from the outside of the vessel and to free the intima; ways to dry the surface and to separate endothelial cells are examined. The paper gives the figures of specimens stained by the Romanowsky-Giemsa method and identifies factor VIII, an endothelial marker, and Chlamydia pneumoniae inclusions in the cytoplasm of endothelial cells. Read More

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http://dx.doi.org/10.17116/patol20188005151DOI Listing

[A case of solid pseudopapillary tumor of the pancreas: features of the course, difficulty in diagnosis].

Arkh Patol 2018;80(5):46-50

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Solid pseudopapillary tumor is a low-grade malignant neoplasm of the pancreas. The clinical manifestations are variable, ranging from an asymptomatic course to cases with severe symptoms that dramatically impair the patients' status. The paper describes the rare case of a solid pseudopapillary tumor in a 34-year-old woman, which was accompanied by difficulties in the interpretation of clinical data and morphological patterns. Read More

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http://dx.doi.org/10.17116/patol20188005146DOI Listing

[Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene].

Arkh Patol 2018;80(5):40-45

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper describes a case of essential cryoglobulinemia unassociated with hepatitis B and C viruses. The morphological substrate of the disease was exclusively proliferative endothrombovasculitis without destructive changes in the walls of affected vessels. In addition, in the late stage of the disease, there was its unusual manifestation associated with inflammation of the mesentery arteriolar walls and with the formation of occlusive blood clots in their lumens, which led to severe abdominal diseases. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/5/dow
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http://dx.doi.org/10.17116/patol20188005140DOI Listing
March 2019
14 Reads

[The morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with hereditary thrombophilias and undifferentiated connective tissue dysplasia].

Arkh Patol 2018;80(5):33-39

Dr. Dimitry Kolosovsky's Hematological Office, Moscow, Russia.

Hereditary thrombophilias (HT) and undifferentiated connective tissue dysplasia (uCTD) are important causes of female infertility. Moreover, there are signs of their common pathogenesis: a number of proteins, such as PAI-1, play an important role in the pathogenesis of both conditions, as well as in the development of infertility in patients with HT and uCTD OBJECTIVE: To determine the morphological substrate and molecular mechanisms of impaired pregnancy outcomes in women with uCTD and HT. SUBJECT AND METHODS: A study group included 130 reproductive-aged female patients with primary infertility and a control group consisted of 11 patients (surrogate mothers). Read More

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http://dx.doi.org/10.17116/patol20188005133DOI Listing
March 2019
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[Comparative morphological characteristics and immunophenotype of urothelial carcinomas of the renal pelvis and bladder].

Arkh Patol 2018;80(5):23-32

Department of Pathoanatomy, Tashkent Medical Academy, Tashkent, Respublica Uzbekistan.

Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/5/dow
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http://dx.doi.org/10.17116/patol20188005123DOI Listing
March 2019
7 Reads

[Growth mechanisms and morphological structural features of large uterine leiomyoma].

Arkh Patol 2018;80(5):16-22

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the growth mechanisms of large uterine leiomyoma (LULM) on the basis of a clinical morphology examination, by providing immunohistochemical (IHC) characteristics of the expression of growth factors (transforming growth factor-beta (TGFβ) and platelet-derived endothelial cell growth factor (PD-ECGF)) and markers of stemness (CD117/c-kit, Connexin 43, Nestin) and proliferation (Ki-67).

Subject And Methods: The investigators examined surgical specimens from 38 women diagnosed with simple uterine leiomyoma (ULM), who had been divided into two groups: 1) 21 patients with LULM (>6 cm in diameter) (a study group); 2) 17 patients with small ULM (<4 cm in diameter) (a comparison group). Each group was also divided into two age subgroups (younger (<45 years) and older (≥45 years) subgroups (1a (n=12), 1b (n=9), 2a (n=8) and 2b (n=9), respectively. Read More

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http://dx.doi.org/10.17116/patol20188005116DOI Listing
March 2019
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[Costal cartilage changes in children with pectus excavatum and pectus carinatum].

Arkh Patol 2018;80(5):8-15

Institute of Regenerative Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.

Pectus excavatum (PE) and pectus carinatum (PC) in children are the most common congenital deformities that cause complications in the thoracic organs; however, the role of chondrocytes and cartilage canals in the pathogenesis of these conditions remains unexplored.

Objective: To investigate qualitative and quantitative changes of cartilage lacunae and canals in the costal cartilages in children with PE and PC compared to those with normal chests.

Subject And Methods: Costal cartilages were investigated in 10 children with normal chests (a control group), in 12 children with PE, and in 12 children with PC. Read More

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http://dx.doi.org/10.17116/patol2018800518DOI Listing
March 2019
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[Alma mater of Russian pathoanatomy (on the occasion of the 170th anniversary of the Department of Pathoanatomy, I.M. Sechenov First Moscow State Medical University)].

Authors:
V S Paukov

Arkh Patol 2018;80(5):3-7

Department of Pathoanatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

The paper describes the history of the Department of Pathoanatomy, I.M. Sechenov First Moscow Medical University (Sechenov University) from its establishment in 1849 to the present time. Read More

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http://dx.doi.org/10.17116/patol2018800513DOI Listing

[Clinical and morphological characteristics of parathyroid carcinoma].

Arkh Patol 2018;80(4):65-72

M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia.

Parathyroid carcinoma (PTC) is a rare malignant tumor with the clinical manifestation of hyperparathyroidism, reliable morphological signs of invasive growth, and poor clinical prognosis. The differential diagnosis of PTC due to the rarity of this pathology, not always explicit morphological criteria, and the lack of a certain immunohistochemical panel is complex and needs further clarification. The paper summarizes an update on the clinical and morphological characteristics of PTC. Read More

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http://dx.doi.org/10.17116/patol201880465DOI Listing
February 2019
2 Reads

[Role of intercellular slit-like contacts (connexins) in the pathogenesis of erythroderma].

Arkh Patol 2018;80(4):61-64

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Erythroderma is a skin lesion characterized by redness, swelling, infiltration, and desquamation of greater than 90% of the skin. The etiology of erythroderma is not completely clear and the lesion can be manifestations of various chronic dermatoses, including atopic dermatitis, psoriasis, eczema, and toxicodermia, and be represented by erythrodermic mycosis fungoides. The pathogenesis of erythroderma especially at the genetic level remains little studied. Read More

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http://dx.doi.org/10.17116/patol201880461DOI Listing
February 2019
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[Inherited epidermolysis bullosa].

Arkh Patol 2018;80(4):54-60

Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.

Objective: To summarize an update on epidermolysis bullosa as a polymorphic group of inherited diseases with a failure of epidermal-dermal integrity. Emphasis is placed on the role of transmission electron microscopy in diagnosis and search directions for new types of the abnormality and its molecular markers. Despite numerous mutations in the genes encoding the components of desmosomes and epithelial basement membrane, the stereotyped manifestations of pathological processes in the group of epidermolysis bullosa have been identified. Read More

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http://dx.doi.org/10.17116/patol201880454DOI Listing
February 2019

[Left ventricular noncompaction].

Arkh Patol 2018;80(4):47-53

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.

This paper provides a literature review on left ventricular noncompaction (noncompact cardiomyopathy). It details the historical aspects, epidemiology, ethology, pathophysiology, clinical features, diagnosis, treatment, and prognosis of this abnormality. Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2018/4/dow
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http://dx.doi.org/10.17116/patol201880447DOI Listing
February 2019
1 Read