9,780 results match your criteria Arkhiv patologii[Journal]


[Abnormal gut microbiota-induced hypoestrogenemia as a possible risk factor for malignancy in endometrioid heterotopia].

Arkh Patol 2020 ;82(2):57-61

Smolensk State Medical University, Ministry of Health of Russia, Smolensk, Russia; Smolensk Regional Institute of Pathology, Ministry of Health of Russia, Smolensk, Russia.

This paper reveals the pathogenetic impact of the abnormal gut microbiota on the development of female reproductive system diseases. A dynamic imbalance between the altered microbiota and the macroorganism has many manifestations as hormonal homeostatic disorders, one of which is dysbiosis-induced hypoestrogenemia. Using endometrioid heterotopia as an example, the authors trace the possibility of its progression and malignancy due to the occurrence of primary breakdown of the PTEN tumor-suppressor gene with subsequent genetic abnormalities in the ARID1A and TP53 genes. Read More

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http://dx.doi.org/10.17116/patol20208202157DOI Listing

[Clinical and morphological analysis of a caseof Parkinson's disease].

Arkh Patol 2020 ;82(2):52-56

Research Center of Neurology, Moscow, Russia.

Parkinson's disease (PD) is a neurodegenerative disease that belongs to a group of cerebral proteinopathies. The main pathomorphological signs of PD are neuronal degeneration in the midbrain substantia nigra and detection of pathological forms of the synaptic protein α-synuclein in the nigral neurons. At the same time, the pathological forms of α-synuclein in this disease have been recently shown to accumulate in the cells of not only the central, but also peripheral autonomic nervous system. Read More

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http://dx.doi.org/10.17116/patol20208202152DOI Listing

[Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children].

Arkh Patol 2020 ;82(2):43-51

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Secretory carcinoma of the salivary gland is a tumor that was first described less than 10 years ago and that mainly occurs in the parotid salivary gland in the elderly. Analyzing the literature over 8 years since the first description of the tumor identifies the main clinical, morphological, and genetic signs of the diagnosis of secretory carcinoma with a focus on the pediatric population. Four new cases of secretory carcinoma of the salivary glands, which have been diagnosed in children of the youngest age encountered in the literature, are also described. Read More

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http://dx.doi.org/10.17116/patol20208202143DOI Listing

[A new one in the classification of benign colon epithelial tumors (WHO, 2019, 5th edition)].

Arkh Patol 2020 ;82(2):35-42

Lomonosov Moscow State University, Medical Research and Educational Center, 119192, Russian Federation, Moscow, Lomonosovsky Prospekt, 27-10.

The 2019 WHO Classification of Benign Colon Epithelial Neoplasms includes serrated dysplasia, adenomatous polyps, and glandular intraepithelial neoplasia. Serrated dysplasia (ICD-O 8213/0 and 8213/2) is former serrated masses. There is an expected change in its terminology: it is proposed to use the term 'sessile serrated lesion' (SSL) instead of that 'sessile serrated polyp/adenoma' that causes a lot of discussion. Read More

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http://dx.doi.org/10.17116/patol20208202135DOI Listing

[Impaired expression of cell-cycle regulatory proteins in seborrheic keratosis].

Arkh Patol 2020 ;82(2):30-34

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Seborrheic keratosis (SK) is a benign skin tumor of unknown etiology and pathogenesis. Many details remain unclear despite that there have been a number of studies of cell-cycle abnormalities.

Aim: to investigate the expression of the cell-cycle regulatory proteins p53 and p16 and the cell proliferation marker Ki-67 in SK. Read More

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http://dx.doi.org/10.17116/patol20208202130DOI Listing

[The morphological characteristics and immunophenotype of renal cell carcinomas with eosinophilic cytoplasm].

Arkh Patol 2020 ;82(2):20-29

Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; Department of Pathological Anatomy, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Eosinophilic cellular renal cell carcinomas embrace a wide range of histological types described in the 2016 WHO International Classification of Kidney Tumors. A variety of histological manifestations associated with the features of tumor morphogenesis in this group poses difficulties in differential diagnosis.

Aim: to investigate the morphological and immunophenotypic features of rare types of renal cell carcinomas with eosinophilic cytoplasm. Read More

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http://dx.doi.org/10.17116/patol20208202120DOI Listing

[Pathological anatomy of tuberculosis in the presence of human immunodeficiency virus infection].

Arkh Patol 2020 ;82(2):12-19

S.P. Botkin Clinical Infectious Diseases Hospital, Saint Petersburg, Russia.

Tuberculosis occupies a leading position among secondary infections in the structure of mortality in HIV-positive patients. Moreover, the concurrence of these diseases frequently makes a morphological diagnosis most difficult due to the atypical course of tuberculosis (TB) in the presence of immunosuppression.

Aim: to assess the clinical and morphological characteristics of concurrent TB/HIV infection. Read More

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http://dx.doi.org/10.17116/patol20208202112DOI Listing

[Claudin-3 expression in gastric cancer].

Arkh Patol 2020 ;82(2):5-11

Medical Research and Educational Center, M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, Moscow, Russia.

Claudins are a family of transmembrane proteins which are essential for the formation and maintenance of epithelial tight junctions. Altered expression of claudins may lead to structural and functional damage of tight junctions, which plays an important role in tumorigenesis and cancer progression. The expression of claudin-3 in gastric cancer is not yet well understood. Read More

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http://dx.doi.org/10.17116/patol2020820215DOI Listing

[Cancer-associated fibroblasts and their significance in tumor progression].

Arkh Patol 2020 ;82(1):68-77

M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Carcinogenesis and tumor progression are not caused not only by malignant epithelial cells, but also by the tumor stroma around cancer stem cells which performs regulatory, nutritional and 'framework' functions. It is represented by mesenchymal cells of various types predominantly by cancer-associated fibroblasts (CAF). αSMA, FAP-1, desmin, podoplanin, neuron-glial antigen 2 (NG2), PDGFR-α and -β are used for CAF identification but there is no universal markers due to the plasticity of the cell population that underlies the subpopulation division CAF. Read More

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http://dx.doi.org/10.17116/patol20208201168DOI Listing
February 2020

[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?]

Arkh Patol 2020 ;82(1):62-67

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia.

Objective: To reveal the morphological characteristics of simultaneously diagnosed leiomyoma of the corpus uteri and vulva.

Subject And Methods: The paper describes a case of multiple uterine leiomyomas concurrent with vulvar leiomyoma in a 39-year-old patient with progressive tumor nodule growth over 2 years. Vulvar tumor was biopsied simultaneously with extirpation of the uterus; vulvar leiomyoma was removed six months later. Read More

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http://dx.doi.org/10.17116/patol20208201162DOI Listing
February 2020

[Biphasic (dedifferentiated) osteosarcoma of the lung in the light of current ideas on biphasic tumors].

Arkh Patol 2020 ;82(1):56-61

Tomsk Regional Clinical Hospital, Tomsk, Russia; Tomsk Regional Prosectorium, Tomsk, Russia.

The paper presents a case of biphasic (dedifferentiated) osteosarcoma arising primarily on the lung, which has not previously encountered in the literature. It provides a detailed description of its clinical, instrumental, and morphological pattern. It also analyzes the literature on the study of primary pulmonary osteosarcoma and extraskeletal osteosarcoma with high-grade transformation. Read More

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http://dx.doi.org/10.17116/patol20208201156DOI Listing
February 2020

[Fatal dengue fever].

Arkh Patol 2020 ;82(1):52-55

Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.

Dengue fever is acute zooanthroponic infection from a group of vector-borne viral hemorrhagic fevers. Since 2013, Russia has introduced the mandatory registration of dengue fever cases. The paper presents data on the epidemiology, etiology, and pathogenesis of Dengue fever and describes a case of a fatal outcome in severe dengue fever and morphological changes in organs and tissues. Read More

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http://dx.doi.org/10.17116/patol20208201152DOI Listing
February 2020

[Liver alveococcosis concurrent with hepatocellular carcinoma (autopsy observation)].

Arkh Patol 2020 ;82(1):47-51

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

The paper presents a unique case of an autopsy study of the concurrence of two diseases, such as liver alveococcosis and hepatocellular carcinoma, in a 46-year-old woman with obvious hypercoagulability syndrome caused by parasitic invasion. It gives the macroscopic and histological characteristics of this case. Read More

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http://dx.doi.org/10.17116/patol20208201147DOI Listing
February 2020

[Tanatogenetic role of type 2 diabetes in neurosurgical patients].

Arkh Patol 2020 ;82(1):38-46

A.L. Polenov Russian Neurosurgical Institute, Branch, V.A. Almazov National Medical Research Center, Ministry of Health of Russia, Saint-Petersburg, Russia.

The idea of diabetes in the aspects of its impact on the course of different diseases and tanatogenesis remains little investigated.

Objective: To define the tanatogenetic significance of 2 type diabetes in neurosurgical patients.

Subject And Methods: Forty-three patients aged 22-75 years, who had died after neurosurgery, were examined. Read More

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http://dx.doi.org/10.17116/patol20208201138DOI Listing
February 2020

[Role of IL-17A and neutrophilic granulocytes in the pathogenesis of psoriasis].

Arkh Patol 2020 ;82(1):30-37

State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of Russia, Moscow, Russia.

Objective: To study the expression of IL-17A in the inflammatory infiltrating cells in the plaques as one of the key points in the pathological process in moderate to severe psoriasis.

Material And Methods: The material obtained from 50 patients with moderate and severe psoriasis was examined by an indirect immunofluorescence assay to determine the composition of cell infiltrate and the type of IL-17A-producing cells in the foci of lesion. The markers of lymphocytes (CD3), dendritic cells (CD11c), neutrophilic granulocytes (Mpo), and mast cells (Trp) were used. Read More

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http://dx.doi.org/10.17116/patol20208201130DOI Listing
February 2020

[Pathomorphological features of the placentas and the placental sites after in vitro fertilization with a donor egg].

Arkh Patol 2020 ;82(1):23-29

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Objective: To identify the structural and immunohistochemical features of the placentas and the placental sites after in vitro fertilization (IVF) with a donor egg (surrogate motherhood).

Subject And Methods: Morphological and immunohistochemical studies were performed on the placental (a placental disk) and placental bed materials obtained after caesarean delivery. The investigation enrolled 26 patients whose pregnancy occurred with IVF with a donor egg according to the surrogacy (IVF-S) program. Read More

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http://dx.doi.org/10.17116/patol20208201123DOI Listing
February 2020

[Thyroid follicular cell tumors: cytohistological comparisons in the context of the new international classification].

Arkh Patol 2020 ;82(1):15-22

National Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Objective: To carry out a correlation retrospective analysis of the histological and cytological findings of follicular cell neoplasms over a two-year period after the publication of the new WHO classification of thyroid tumors (2017), which identifies a category of follicular tumors of uncertain malignant potential (T-UMP).

Material And Methods: The investigators of the Clinic, National Medical Research Center for Endocrinology, Ministry of Health of Russia, made a cytohistological comparison of morphological findings, by using the material of surgically removed follicular cell neoplasms.

Results: The investigation showed the lack of unreasonably common usage of the histological classification category of T-UMP (3. Read More

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http://dx.doi.org/10.17116/patol20208201115DOI Listing
February 2020

[Immunohistochemical study of the MSI phenotype of urothelial bladder cancer].

Arkh Patol 2020 ;82(1):5-14

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the MSI phenotype of urothelial bladder cancer (BC) by immunohistochemistry (IHC) and to assess its relationship to the prognostic factors of the disease and PD-L1 status of BC.

Material And Methods: Using the surgical and biopsy materials obtained from 50 patients with BC during examination and treatment, the investigators studied the MSI phenotype by IHC. A system was proposed to assess the IHC expression of MSI proteins, by taking into account the intensity of nuclear staining and the area occupied by tumor cells with stained nuclei. Read More

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http://dx.doi.org/10.17116/patol2020820115DOI Listing
February 2020

[Updated 2018 ASCO/CAP recommendations on the definition of human epidermal growth factor receptor type 2 (HER2) in breast cancer].

Arkh Patol 2019 ;81(6):82-85

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

A summary of the updated recommendations of the 2018 American Society of Clinical Oncology (ASCO) / College of American Pathologists (CAP), devoted to testing type 2 human epidermal growth factor receptor (HER2) in breast cancer. Read More

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http://dx.doi.org/10.17116/patol20198106182DOI Listing
December 2019

[Primary splenic angiosarcoma].

Arkh Patol 2019 ;81(6):78-81

State Research Center A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow, Russia.

Primary splenic angiosarcoma is a rare and high-grade vascular tumor having a significant metastatic potential. The authors give the data available in the literature and describe their own case of primary splenic angiosarcoma in a 42-year-old male patient with multiple distant metastases in the lymph nodes and skin. The paper shows some difficulties in the morphologic diagnosis of this tumor. Read More

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http://dx.doi.org/10.17116/patol20198106178DOI Listing
December 2019

[Gastric damage in systemic sarcoidosis].

Arkh Patol 2019 ;81(6):74-77

V.A. Almazov National Medical Research Center, Ministry of Health of Russia, Saint-Petersburg, Russia.

Sarcoidosis is a multisystem disease of unknown etiology, characterized by specific granulomas without caseous necrosis in the affected organs and tissues. Along with respiratory organs, the gastrointestinal tract may be affected by sarcoidosis. Due to the rarity of gastric involvement of sarcoidosis, substantial difficulties arise in verifying the diagnosis, making a differential diagnosis, and examining gastric biopsy specimens. Read More

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http://dx.doi.org/10.17116/patol20198106174DOI Listing
December 2019

[Protocol for histological examination of liver transplant dysfunction].

Arkh Patol 2019 ;81(6):71-73

A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia, Moscow, Russia.

The protocol for histological examination of liver transplant dysfunction, which is used at the A.I. Burnazyan, Federal Medical and Biophysical Center and has been developed on the basis of the liver transplant rejection protocol designed at the University of Pittsburgh, is proposed for routine use. Read More

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http://dx.doi.org/10.17116/patol20198106171DOI Listing
December 2019

[Mast cells in the microenvironment of uveal melanoma].

Arkh Patol 2019 ;81(6):63-70

Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of Russia, Moscow, Russia.

Objective: To study the morphological features of the microenvironment of a tumor nodule in the eyes with uveal melanoma, focusing on mast cells.

Material And Methods: A total of 43 enucleated eyes with uveal melanoma (260 histological specimens) were examined. The patients' age averaged 54±2. Read More

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http://dx.doi.org/10.17116/patol20198106163DOI Listing
December 2019

[Role of clustered HER2/neu amplification as a marker for a special sensitivity to neoadjuvant anti-HER2 therapy with trastuzumab in patients with stage II-III breast cancer].

Arkh Patol 2019 ;81(6):56-62

Russian Medical Academy of Continuing Professional Education, Moscow, Russia.

Objective: To evaluate the influence of clinical and morphological factors and HER2 copy numbers on pathologic complete response (pCR) rates in patients with HER2-positive stage II-III breast cancer (BC).

Material And Methods: Treatment results were studied in 73 patients with HER2-positive Stage II-III BC, who received treatment at the N.N. Read More

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http://dx.doi.org/10.17116/patol20198106156DOI Listing
December 2019

[HER2/neu gene amplification as a mechanism of clonal heterogeneity in breast cancer].

Arkh Patol 2019 ;81(6):49-55

GBU 'Rostov Regional Bureau of Pathology', Rostov-on-Don, Russia.

Objective: To estimate the heterogeneity of HER2/neu gene amplification in HER2/neu-positive breast cancer (BC).

Material And Methods: Fluorescence in situ hybridization (FISH) assay was used to estimate HER2/neu gene amplification and HER2/CEP17 ratios in BC samples with an immunohistochemical evaluation of HER2/neu2+ expression. The results were interpreted according to the 2018 ASCO/CAP guidelines. Read More

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http://dx.doi.org/10.17116/patol20198106149DOI Listing
December 2019

[Endometrial morphological characteristics in patients with hysteromyoma and chronic endometritis in infertility].

Arkh Patol 2019 ;81(6):41-48

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia.

Objective: To characterize endometrial structural and functional state and receptivity in women with hysteromyoma (HM) and chronic endometritis (CE) in infertile couples.

Material And Methods: A total of 130 patients who had HM and/or CE in an infertile couple were examined. Group 1 included 64 women with HM and CE; Group 2 consisted of 24 patients with HM; group 3 comprised 42 patients with EC. Read More

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http://dx.doi.org/10.17116/patol20198106141DOI Listing
December 2019

[The expression of EMMPRIN and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma].

Arkh Patol 2019 ;81(6):34-40

V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the features of expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma (CSCC).

Material And Methods: The investigation was conducted using the surgical material obtained after hysterectomy in patients diagnosed as having CSCC. RT-PCR, immunohistochemistry (IHC), and enzymatic assays were used. Read More

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http://dx.doi.org/10.17116/patol20198106134DOI Listing
December 2019

[Expression of LMP-1 protein in tumor cells and glandular epithelium of the peritumoral tissue in gastric cancer].

Arkh Patol 2019 ;81(6):24-33

Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Objective: To study the relationship of LMP-1 expression with the clinical and morphological characteristics of gastric cancer and to study LMP-1 expression in the glandular epithelium of the peritumoral tissue.

Material And Methods: Samples of gastric cancer surgical material from 67 patients were included in this study. Primary mouse monoclonal antibodies to LMP-1 protein were used. Read More

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http://dx.doi.org/10.17116/patol20198106124DOI Listing
December 2019

[The cellular composition of explanted bioprosthetic heart valves in infective endocarditis].

Arkh Patol 2019 ;81(6):16-23

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.

Objective: To perform immunohistochemical typing of cells as a component of bioprosthetic (BP) heart valves explanted during reoperations for prosthetic valve endocarditis.

Material And Methods: The authors investigated 8 models of KemCor and PeriCor artificial heart valves produced by NeoCor Company (Kemerovo, Russia), which were explanted from the mitral position due to infection of xenogeneic implanted material. The following markers: CD3 (T-lymphocytes), CD20 (B-lymphocytes), CD34 and VEGFR2 (endotheliocytes), CD68 (monocytes/macrophages), vimentin (fibroblasts), and α-smooth muscle actin (smooth muscle cells), were used for immunohistochemical typing of cells as a component of the analyzed samples. Read More

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http://dx.doi.org/10.17116/patol20198106116DOI Listing
December 2019

[Hypertrophic cardiomyopathy. Cardiomyocyte ultrastructure, the specific or stereotypic signs].

Arkh Patol 2019 ;81(6):5-15

A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russia, Moscow, Russia.

Hypertrophic cardiomyopathy (HCM) is a congenital disease caused by mutations in a number of sarcomere proteins. According to the type of mutation, clinical observations record similar clinical manifestations, myocardial pathological changes, and the timing of manifestation of the disease in HCM patients.

Objective: To study cardiomyocyte (CMC) ultrastructural changes in the interventricular septum (IVS) of patients with HCM and evaluate their specificity for this pathology. Read More

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http://dx.doi.org/10.17116/patol2019810615DOI Listing
December 2019

[Molecular genetic markers and criteria for the prediction of adrenocortical carcinoma].

Arkh Patol 2019 ;81(5):92-96

National Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Studies of the last decade have demonstrated that the morphological and immunophenotypic patterns of adrenocortical carcinoma (ACC) have a high heterogeneity in both the occurrence of various tumors and the development of a solitary tumor. Carcinogenesis of ACC, like most neoplastic processes, is associated with mutations in at least 15 driver genes, with a wide range of chromosomal aberrations, epigenomic changes, and alterations of the microRNA profile. According to the literature, isolated genetic damage is also insufficient for the manifestation of the malignant phenotype of adrenocortical cells. Read More

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http://dx.doi.org/10.17116/patol20198105192DOI Listing
December 2019
2 Reads

[Congenital giant melanocytic nevi].

Arkh Patol 2019 ;81(5):89-91

Urals Research Institute for Maternal and Child Care, Ministry of Health of Russia, Yekaterinburg, Russia.

The paper describes a case of a rare tumor disease with massive involvement of the skin, mainly that of the occipital head and brain and liver tissues in a newborn infant. It considers the morphological and immunohistochemical characteristics of a giant tumor cell nidus in the skin of the occipital head. Read More

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http://dx.doi.org/10.17116/patol20198105189DOI Listing
December 2019
9 Reads

[The morphological and molecular genetic characteristics of nephroblastomas in immature ovarian teratoma in adult patients].

Arkh Patol 2019 ;81(5):80-88

D.D. Pletnev City Clinical Hospital, Moscow Healthcare Department, Moscow, Russia.

The paper describes 2 cases of immature ovarian teratoma with elements of nephroblastoma (ICD-0 code 9080/3) in patients aged 61 and 70 years. Microscopic examination revealed that both cases had blastemal cells with scant cytoplasm and basophil nuclei sticking together. Epidermal, glandular, rhabdomyoblastic, chondroid, bone, neuroectodermal, and histiocytic components were determined. Read More

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http://dx.doi.org/10.17116/patol20198105180DOI Listing
December 2019
1 Read

[Tumor-like amyloidosis of the upper respiratory tract].

Arkh Patol 2019 ;81(5):74-79

Research and Clinical Center for Otorhinolaryngology, Federal Biomedical Agency of Russia, Moscow, Russia.

The paper describes 11 cases of local tumor-like amyloidosis (LTA) of the upper respiratory tract, among which laryngeal amyloidosis was most common. The clinical diagnosis of suspected local amyloidosis was made in only two cases. The diagnosis of local amyloidosis was established at a morphological examination of a distant neoplasm, by using special Congo red staining followed by polarizing microscopy. Read More

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http://dx.doi.org/10.17116/patol20198105174DOI Listing
December 2019

[A case of Lambl's excrescences of the mitral valve concurrent with myocardial infarction].

Arkh Patol 2019 ;81(5):70-73

Research Institute of Human Morphology, Moscow. Russia.

Lambl's excrescences are a rare disease that is characterized by a lesion of the heart valves as filamentous growths on their surface mainly along the coaptation lines and that is mostly asymptomatic. Due to traumatic injuries during heart contractions, fibrin masses can be deposited on the surface of the growths, contributing to thromboembolic events or infection. The paper provides the data available in the literature and demonstrates a postmortem observation of Lambl's excrescences on the ventricular surface of the mitral valve concurrent with myocardial infarction. Read More

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http://dx.doi.org/10.17116/patol20198105170DOI Listing
December 2019

[Evaluation of the effect of remaxol on hepatocytes in non-alcoholic fatty liver dystrophy modeling in laboratory C57BL/6 mice].

Arkh Patol 2019 ;81(5):64-69

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia.

Objective: To provide a morphological evaluation of the effectiveness of incorporating remaxol into a treatment regimen for non-alcoholic fatty liver disease.

Material And Methods: The investigation was conducted using 32 male C57BL/6 mice weighing 35-44 g, which were divided into 4 groups. In Group 1, eight mice were fed with a standard diet for 75 days; the animals from Groups 2 and 3 received a hypercaloric diet for the same period of time. Read More

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http://dx.doi.org/10.17116/patol20198105164DOI Listing
December 2019

[Morphology of the thymus and the specific features of its cellular composition in experimental acute and chronic ulcerative colitis].

Arkh Patol 2019 ;81(5):53-63

Research Institute of Human Morphology, Ministry of Science and Higher Education of Russia, Moscow, Russia.

Objective: To investigate morphological changes in the thymus, the subpopulation composition of lymphocytes and its non-lymphoid cells in dextran-induced experimental acute ulcerative colitis and in different periods of chronic ulcerative colitis.

Material And Methods: Acute and chronic ulcerative colitis was simulated in C57BL/6 mice, by replacing drinking water with a 1% aqueous dextran sulfate sodium solution. Thymic changes were morphometrically assessed; the number and absolute area of thymic corpuscles and epithelial cells were calculated; and the subpopulation composition of lymphocytes and thymic stromal cells was determined using flow cytofluorimetry; the Kruskal-Wallis test and the Mann-Whitney test were used to compare the groups. Read More

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http://dx.doi.org/10.17116/patol20198105153DOI Listing
December 2019
1 Read

[Inflammatory infiltrates, vasa vasorum, and endothelial NO synthase in the wall of thoracic aortic aneurysm].

Arkh Patol 2019 ;81(5):45-52

National Medical Research Center of Cardiology, Ministry of Health of Russia, Moscow, Russia; Research Institute of Human Morphology, Ministry of Science and Higher Education of Russia, Moscow, Russia.

Objective: To elucidate whether there is a relationship between inflammation of the wall of aortic aneurysm and the number of vasa vasorum in it.

Material And Methods: The investigation material was aortic aneurysm wall segments obtained during surgery. Among the patients, there were 20 men and 5 women. Read More

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http://dx.doi.org/10.17116/patol20198105145DOI Listing
December 2019
1 Read

[Morphological and immunohistochemical characteristics of the molecular subtypes of urothelial carcinomas].

Arkh Patol 2019 ;81(5):35-44

Department of Anatomic Pathology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan.

The molecular subtypes of urothelial carcinoma in each classification scheme have characteristic immunohistochemical features. At the same time, the results of conducted studies often demonstrate a discrepancy between the genomic profile of urothelial carcinoma and its immunophenotype, which complicates the immunohistochemical verification of the molecular subtypes of these tumors.

Objective: To compare the morphological and immunophenotypic characteristics of the molecular subtypes of urothelial carcinoma. Read More

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http://dx.doi.org/10.17116/patol20198105135DOI Listing
December 2019
2 Reads

[Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy].

Arkh Patol 2019 ;81(5):30-34

People's Friendship University of Russia, Moscow, Russia

Objective: To investigate the expression of Ki-67, phosphohistone H-3 (PHH3), and cytokeratin 15 (CK15) proteins in the cells of the oral mucosa (OM) according to the degree of its malignant transformation.

Material And Methods: OM biopsy specimens from 69 patients diagnosed with focal epithelial hyperplasia, intraepithelial squamous cell neoplasia, cancer in situ, and squamous cell carcinoma were examined. Tissue antigens were determined using mouse Ki-67 monoclonal antibodies, rabbit PHH3 polyclonal antibodies, and mouse CK15 monoclonal antibodies. Read More

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http://dx.doi.org/10.17116/patol20198105130DOI Listing
December 2019
1 Read

[Morphological features of IgG4-related lesions at various sites].

Arkh Patol 2019 ;81(5):22-29

A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia, Moscow, Russia.

Objective: To determine the morphological features of IgG4-related lesions and to improve pathomorphological criteria for diagnosing various clinical variants of IgG4-related disease.

Material And Methods: Biopsy and surgical materials from 100 patients with tumor-like lesions at various sites (63 cases of IgG4-related lesion and 37 cases of non-IgG4-related inflammatory processes) were studied. Histological and immunohistochemical studies were conducted to determine the absolute counts of CD138+ cells, IgG+ and IgG4+ in the inflammatory infiltrates, as well as IgG4/IgG and IgG4/CD138 cell ratios. Read More

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http://dx.doi.org/10.17116/patol20198105122DOI Listing
December 2019
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[Differential diagnostic value of the expression of the transcription factor PDX-1 in neuroendocrine and non-neuroendocrine tumors of the pancreas and other organs].

Arkh Patol 2019 ;81(5):11-21

M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia.

An important role in the differentiation of tissues in different organs is played by transforming factors (TFs); pancreatic and duodenal homebox 1 (PDX-1) is one of the earliest factors for pancreatic cells. Many malignant tumors, including neuroendocrine tumors (NETs), are similar in structure, and therefore the actual problem of oncomorphology is to search for narrow-specific markers and TFs.

Aim: to comparatively analyze and assess the value of the expression of the TF PDX-1 in NETs and non-NETs of different localization and histogenetic origin. Read More

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http://dx.doi.org/10.17116/patol20198105111DOI Listing
December 2019
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[Study of the PD-L1 status in breast cancer, by using the SP142 monoclonal antibody, and the prospects for determining treatment policy].

Arkh Patol 2019 ;81(5):5-10

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Objective: To investigate the expression of programmed death ligand 1 (PD-L1) in triple-negative and luminal B, HER2-negative breast cancer, by using the SP142 antibody and to assess the association of the PD-L1 status with prognosis for patients.

Material And Methods: The study was conducted using surgical materials (full sections) obtained from 72 patients. The sections were stained with the SP142 PD-L1 antibody. Read More

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http://dx.doi.org/10.17116/patol2019810515DOI Listing
December 2019

[Report on a round of the quality control of immunohistochemical studies].

Arkh Patol 2019;81(4):83-84

FGBOU DPO 'Russian Medical Academy of Continuing Professional Education', Moscow, Russia.

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http://www.mediasphera.ru/issues/arkhiv-patologii/2019/4/dow
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http://dx.doi.org/10.17116/patol20198104183DOI Listing
October 2019
3 Reads

[Features of the development of latent autoimmune diabetes in adults (LADA)].

Arkh Patol 2019 ;81(4):78-82

Akad. A.I. Strukov Department of Pathologic Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

The study of the sociomedical problems of diabetes mellitus led to the discovery of latent autoimmune diabetes in adults (LADA), a special form of the disease. The slow onset of the disease, the clinical signs of type 2 diabetes mellitus concurrent with the autoantibody pancreatic β-cell destruction mechanism that is characteristic of type 1 diabetes. Genetic factors play an important role in the genesis of the disease. Read More

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http://dx.doi.org/10.17116/patol20198104178DOI Listing
October 2019
2 Reads

[Circulatory intranatal hypoxia].

Authors:
V V Vlasyuk

Arkh Patol 2019 ;81(4):73-77

Department of Forensic Medicine, S.M. Kirov Military Medical Academy, Ministry of Defense of Russia, Saint Petersburg, Russia.

The paper considers one of the types of intranatal fetal hypoxia - circulatory hypoxia. It discusses the issues of fetal head configuration during childbirth and the compensatory-adaptive mechanisms when the fetal head passes through the maternal parturient canal. The relationships and differences between circulatory hypoxia and birth trauma are investigated. Read More

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http://dx.doi.org/10.17116/patol20198104173DOI Listing
October 2019

[Correct use of Kreatech DNA probes to detect MYC gene amplification in medulloblastomas by fluorescence in situ hybridization].

Arkh Patol 2019 ;81(4):66-72

Acad. N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of Russia, Moscow, Russia.

In most cases, oncogene amplification are prognostic and predictive markers for various tumors, therefore DNA probes are unable to reveal changes in the copy numbers should not be used to diagnose malignant tumors.

Objective: To comparatively analyze DNA probes from different manufacturers to detect MYC gene amplification in routine practice.

Material And Methods: The study material was formalin-fixed paraffin-embedded medulloblastoma fragments from 4 patients, with discrepancies in the results in the detection of MYC gene amplification. Read More

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http://dx.doi.org/10.17116/patol20198104166DOI Listing
October 2019
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[Effects of cytoflavin on neuronal apoptotic processes in the murine cerebral cortex on a model of physiologicaland pathological aging].

Arkh Patol 2019 ;81(4):59-65

Astrakhan State University, Astrakhan, Russia.

Involutional changes in the cerebral cortex substantially affect the activity of the cortex itself and the function of target organs. This necessitates pharmacological correction of age-related diseases, primarily a high level of cell death.

Objective: To investigate the role of cytoflavin in mechanisms for the apoptotic regulation of cerebral cortical cells during physiological and pathological aging (in the presence of HER-2/neu overexpression). Read More

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http://dx.doi.org/10.17116/patol20198104159DOI Listing
October 2019

[Clinical and morphological characteristics of thyroid tumors in children of the Chelyabinsk Region].

Arkh Patol 2019 ;81(4):53-58

Chelyabinsk Regional Forensic Medical Examination Bureau, Ministry of Health of the Chelyabinsk Region, Chelyabinsk, Russia.

Objective: To carry out a clinical and morphological analysis of thyroid cancer cases in the children of the Chelyabinsk Region.

Subject And Methods: Thyroid tumor pathology was verified in 50 of the 196 patients aged 7-17 years, who had been operated on in 2000-2016. Clinical and morphological features, including immunohistochemical and ultrastructural characteristics of thyroid cancer, were studied. Read More

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http://dx.doi.org/10.17116/patol20198104153DOI Listing
October 2019
4 Reads

[Nosological structure of congenital malformations in the fetuses and babies of the Aral Sea Region(the Republic of Kazakhstan)].

Arkh Patol 2019 ;81(4):48-52

Regional Postmortem Office, Public Health Department of the Kyzylorda Region, Kyzylorda, Republic of Kazakhstan.

Objective: To study the trend in the incidence and nosological structure of congenital malformations (CMFs) in the fetuses and babies of the Kyzylorda Region (Aral Sea Region) of the Republic of Kazakhstan in the period 2016-2018.

Material And Methods: Over 2016-2018, the investigators analyzed 550 childbirth histories, the protocol (records) of autopsy in fetuses and babies who had died at the maternity hospitals and children's hospitals of the Kyzylorda Region (Aral Sea Region, Kazakhstan).

Results: Throughout the follow-up period, the structure of CMFs in the Kyzylorda Region, the Republic of Kazakhstan, was found to have 3 major systemic defects: multiple defects; cardiovascular defects, and central nervous system defects, which can be considered as an indicator for environmental problems in the region. Read More

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http://dx.doi.org/10.17116/patol20198104148DOI Listing
October 2019
3 Reads