2,086 results match your criteria Arhiv za higijenu rada i toksikologiju[Journal]


The role of physics in radioecology and radiotoxicology.

Arh Hig Rada Toksikol 2019 Mar;70(1):3-13

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

This article gives an overview of physical concepts important for radioecology and radiotoxicology to help bridge a gap between non-physicists in these scientific disciplines and the intricate language of physics. Relying on description and only as much mathematics as necessary, we discuss concepts ranging from fundamental natural forces to applications of physical modelling in phenomenological studies. We first explain why some atomic nuclei are unstable and therefore transmute. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3225DOI Listing
March 2019
1 Read

Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells.

Arh Hig Rada Toksikol 2019 Mar;70(1):18-29

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA;

Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary metabolite 3,5-dimethylaminophenol (3,5-DMAP) showed that this compound causes oxidative stress, changes antioxidant enzyme activities, and leads to death of different mammalian cells. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3159DOI Listing
March 2019
1 Read

Inspiratory muscle strength affects anaerobic endurance in professional athletes.

Arh Hig Rada Toksikol 2019 Mar;70(1):42-48

Department of Pulmonology, University Hospital Centre Osijek, Osijek, Croatia.

To the best of our knowledge, little is known about the role of respiratory muscle strength and endurance on athlete performance in anaerobic conditions of maximal exertion. The aim of this cross-sectional study was therefore to examine the association between the strength/endurance of inspiratory muscles in a group of 70 healthy male professional athletes (team sports) and their ventilatory and metabolic parameters at the anaerobic threshold (second ventilatory threshold; VT2) and beyond it at maximum load during the cardiopulmonary exercise test (CPET) on a treadmill. Ventilatory parameters at VT2, at maximal effort, and their differences were tested for association with inspiratory muscle strength (PImax) and endurance (Tlim), measured as time to maintain inspiration at or above 80% of PImax. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3182DOI Listing
March 2019
3 Reads

The effects of occupational lead exposure on selected inflammatory biomarkers.

Arh Hig Rada Toksikol 2019 Mar;70(1):36-41

Provincial Health Directorate,Malatya, Turkey.

In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-α) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-α) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3214DOI Listing
March 2019
4 Reads

The role of basic psychological needs in the perception of job insecurity.

Arh Hig Rada Toksikol 2019 Mar;70(1):54-59

University of Novi Sad, Faculty of Medicine, Department of Psychology, Novi Sad, Serbia.

The aim of this study was to investigate whether satisfied basic psychological needs reduce the perception of threat generated by job insecurity, defined as self-assessment of the availability of the working role to its performers in the foreseeable future. The study included 310 participants employed in 24 companies, who completed the Perception of Job Insecurity Scale and Need Satisfaction Scale. The hypotheses were tested with multiple regression analyses. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3156DOI Listing
March 2019
1 Read

Inhalation poisoning with palytoxin from aquarium coral: case description and safety advice.

Arh Hig Rada Toksikol 2019 Mar;70(1):14-17

Institute of Biological Basis of Animal Production, Faculty of Biology, Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, Lublin, Poland.

Palythoa spp. corals and some other marine organisms contain one of the most poisonous substances ever known - palytoxin (PTX). Due to their modest life requirements and ease of breeding, these corals are popular in home aquariums. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3209DOI Listing
March 2019
2 Reads

The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning.

Arh Hig Rada Toksikol 2019 Mar;70(1):49-53

Toxicological Research Center, Center for Excellence in Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3162DOI Listing
March 2019
7 Reads

Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats.

Arh Hig Rada Toksikol 2019 Mar;70(1):30-35

University of Zagreb, School of Medicine, Department of Pharmacology, Zagreb, Croatia.

The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3215DOI Listing

Happy 70, Archives! - our mission and vision for the years to come.

Arh Hig Rada Toksikol 2019 Mar;70(1):1-2

Institute for Medical Research and Occupational Health, Zagreb, Croatia;

This year we turn 70! Lucky for journals, they don't get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you - our readers and authors - where we see Archives in the years to come. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3272DOI Listing

Keeping children safe from harmful household products: a survey on safety practices in Croatia.

Arh Hig Rada Toksikol 2019 03;70(1):60-61

Institute for Medical Research and Occupational Health, Croatian Poison Control Centre, Occupational Health and Environmental Medicine Unit, Zagreb, Croatia.

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http://dx.doi.org/10.2478/aiht-2019-70-3247DOI Listing

Praćenje vršnog ekspiratornog protoka u dijagnozi profesionalne astme.

Arh Hig Rada Toksikol 2018 Dec;69(4):354-363

Institut za medicinska istraživanja i medicinu rada, Zagreb, Croatia.

Prema podacima iz Registra profesionalnih bolesti Hrvatskoga zavoda za zaštitu zdravlja i sigurnost na radu, u posljednjih deset godina (2008. ‒ 2017.) prijavljeno je samo 20 slučajeva profesionalne astme od ukupno 2234 prijavljene profesionalne bolesti. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3155DOI Listing
December 2018

Seasonal diversity of biodeteriogenic, pathogenic, and toxigenic constituents of airborne mycobiota in a sacral environment.

Arh Hig Rada Toksikol 2018 Dec;69(4):317-327

Department for Algology, Mycology and Lichenology, Belgrade, Serbia.

The main purpose of this study was to isolate airborne fungi and assess seasonal variations in air contamination with their particulates by determining the levels of their propagules in the nave and exonarthex of a church. We also monitored indoor microclimate as a determining factor for fungal proliferation on wall paintings, spore release, and transmission through the air. The temperature and relative humidity of the nave favoured fungal growth. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3194DOI Listing
December 2018
3 Reads

Effect of pretreatments on mycotoxin profiles and levels in dried figs.

Arh Hig Rada Toksikol 2018 Dec;69(4):328-333

Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology, Osijek, Croatia.

The aim of this explorative study was to investigate how effective drying preservation methods are in reducing mycotoxin content in figs. Dried autochthonous varieties of white and dark figs (Petrovača Bijela and Šaraguja, respectively) were analysed for mycotoxins using an LC-MS/MS "dilute and shoot" method capable of determining 295 fungal and bacterial secondary metabolites. Before drying in a cabinet dryer the figs were preserved with 0. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3147DOI Listing
December 2018
2 Reads

A unique case of a 70-hour decompression sickness latency.

Arh Hig Rada Toksikol 2018 Dec;69(4):350-353

Polyclinic Salus, Pula, Croatia.

We report a unique and well-documented case of a type II decompression sickness (DCS) with a latency interval of 70 hours. It may raise divers' awareness and help medical practitioners to keep suspect divers under close observation longer than before and identify and treat DCS accordingly. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3174DOI Listing
December 2018

Organic dust exposure in veterinary clinics: a case study of a small-animal practice in Portugal.

Arh Hig Rada Toksikol 2018 Dec;69(4):309-316

Health & Technology Research Center, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisboa, Portugal.

Literature about occupational health in small-animal veterinary practices is scarce, but most of it has recognised a number of risks to be considered, including organic dust exposure. The aim of this pilot study was to assess organic dust, bacterial, and fungal contamination in the indoor environment of a typical Portuguese veterinary clinic but also to screen for azoleresistant fungi. To complement these findings we also analysed workers' nasal exudates for resistant bacteriota. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3171DOI Listing
December 2018
4 Reads

Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys.

Arh Hig Rada Toksikol 2018 Dec;69(4):286-303

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Chloride/formate exchanger (CFEX; SLC26A6) mediates oxalate transport in various mammalian organs. Studies in Cfex knockout mice indicated its possible role in development of male-dominant hyperoxaluria and oxalate urolithiasis. Rats provide an important model for studying this pathophysiological condition, but data on Cfex (rCfex) localisation and regulation in their organs are limited. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3157DOI Listing
December 2018
1 Read
0.727 Impact Factor

Residential green and blue space associated with better mental health: a pilot follow-up study in university students.

Authors:
Angel M Dzhambov

Arh Hig Rada Toksikol 2018 Dec;69(4):340-349

Department of Hygiene and Ecomedicine, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria.

Previous research has suggested that natural urban environment (green space and blue space) benefit mental health, but only a few longitudinal studies have explored the underlying mechanisms. In this pilot study we aimed to examine mechanisms/variables mediating associations between residential green/blue space and symptoms of anxiety/depression in 109 Bulgarian students from Plovdiv university. The students were followed from the beginning to the end of the school year (October 2017 to May 2018). Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3166DOI Listing
December 2018

Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay.

Arh Hig Rada Toksikol 2018 Dec;69(4):304-308

Department of Biology and Human Genetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Harmful effects of elevated levels of catecholamines are mediated by various mechanisms, including gene transcription and formation of oxidation products. The aim of this study was to see whether the molecular mechanisms underlying the damaging action of adrenaline on DNA are mediated by reactive oxygen species (ROS). To do that, we exposed human whole blood cells to 10 μmol L-1adrenaline or 50 μmol L-1H2O2(used as positive control) that were separately pre-treated or post-treated with 500 μmol L-1of quercetin, a scavenger of free radicals. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3154DOI Listing
December 2018

Removing aflatoxin M1 from milk with native lactic acid bacteria, centrifugation, and filtration.

Arh Hig Rada Toksikol 2018 Dec;69(4):334-339

University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, Croatia.

In order to minimise human exposure to aflatoxin M1 (AFM1) the levels of this highly carcinogenic mycotoxin in milk, heat-treated milk, and other dairy products have been limited to <0.05 μg kg-1. However, its removal from dairy products presents a challenge for dairy producers, as commercial additives change organoleptic properties, and filtration alone yields poor results. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3160DOI Listing
December 2018
4 Reads

Sodium-glucose cotransporters: new targets of cancer therapy?

Arh Hig Rada Toksikol 2018 Dec;69(4):278-285

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3204DOI Listing
December 2018
5 Reads
0.727 Impact Factor

Urban honey - the aspects of its safety.

Arh Hig Rada Toksikol 2018 Sep;69(3):264-274

University of Belgrade Faculty of Chemistry, Belgrade, Serbia.

To contribute to the development of urban beekeeping, we designed this study to obtain more information about the contamination of urban bee products with toxic metals, polycyclic aromatic hydrocarbons (PAHs), and pesticides. The samples of honey (N=23), pollen (N=13), and floral nectar (N=6) were collected from the experimental stationary apiary of the Belgrade University Faculty of Agriculture located in centre of Zemun (a municipality of the Belgrade metropolitan area) in 2015 and 2016. Metals (Pb, Cd, As, Cu, Zn, Fe, Mn, Ni, Cr, and Hg) were determined with inductively coupled plasma quadrupole mass spectrometry (ICP-QMS). Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3126DOI Listing
September 2018
4 Reads

Employment status of workers with a diagnosed occupational disease in Croatia: a 10-year trend (2005-2014).

Arh Hig Rada Toksikol 2018 Sep;69(3):220-225

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Occupational diseases (ODs) often have a chronic, progressive course, resulting in reduced work capacity and quality of life, prolonged sick leaves, unemployment, early retirements, and disability claims. The aim of this retrospective study was to see how diagnosed ODs affected the employment of 95 Croatian workers between 2005 and 2014. To do that, we reviewed archived data and made a telephone survey. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3132DOI Listing
September 2018
2 Reads

Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure.

Arh Hig Rada Toksikol 2018 Sep;69(3):238-249

H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal.

Healthcare workers who prepare or administer cytotoxic agents run the risk of exposure, and the risks for health are real even at doses lower than those applied in cancer patients, because, in theory, no dose is safe. The most common and problematic route of exposure is through the skin, especially as work surfaces can remain contaminated even after cleaning. This pilot study aimed to demonstrate the importance of having an effective surface decontamination protocol by determining surface contamination with cyclophosphamide, 5-fluorouracil, and paclitaxel as the most common cytotoxic drugs in an oncology day service. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3137DOI Listing
September 2018
25 Reads

Occupational exposure to bioburden in Portuguese bakeries: an approach to sampling viable microbial load.

Arh Hig Rada Toksikol 2018 Sep;69(3):250-257

Health & Technology Research Centre, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal.

In bakeries, a number of operations such as mixing are associated with exposure to air-suspended flour dust and related bioburden. The aim of this study was to find the best active sampling approach to the assessment of occupational exposure to bioburden in Portuguese bakeries based on the data obtained with the use of specific impaction and impinger devices. We used impaction to collect fungal particles from 100 L air samples onto malt extract agar (MEA) supplemented with chloramphenicol (0. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3116DOI Listing
September 2018

Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants.

Arh Hig Rada Toksikol 2018 Sep;69(3):215-219

Institute for Medical Research, Division of Clinical & Experimental Immunology, Military Medical Academy School of Medicine, Belgrade, Serbia.

Clara cell protein 16 (CC16) is a small protein mainly produced by non-ciliated Clara cells in the respiratory epithelium. It has an anti-inflammatory role in chronic upper and lower airway eosinophilic inflammations. Decreased levels of CC16 are found in the nasal secretions and plasma of patients with chronic eosinophilic inflammatory disorders, such as asthma, allergic rhinitis, and chronic rhinosinusitis with or without nasal polyps, as well as in people exposed to high levels of air pollutants. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3081DOI Listing
September 2018
2 Reads

A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments.

Arh Hig Rada Toksikol 2018 Sep;69(3):226-237

Careggi University Hospital, Medicina del Lavoro - Laboratorio di Igiene e Tossicologia Industriale, Florence, Italy.

Cytotoxic antineoplastic drugs (ADs) pose occupational risk and therefore require safe handling practices. We created, optimised, and validated an innovative monitoring protocol for simultaneously assessing 21 ADs in the healthcare environment, and also proposed surface exposure levels (SELs) to facilitate the interpretation of monitoring results, as there are currently no occupational exposure limits for ADs. The environmental AD monitoring data were collected in nine Italian hospitals between 2008 and 2017 and include 74,565 measurements in 4,814 wipe samples. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3125DOI Listing
September 2018
1 Read

How sulphur dioxide and storage temperature contribute to patulin degradation in homemade apple juice.

Arh Hig Rada Toksikol 2018 Sep;69(3):258-263

Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia.

Mycotoxin patulin is one of the quality indicators for apple juice. Like other mycotoxins, it raises consumer health concerns. The issue of low quality is particularly relevant for apples provided by small producers, whose quality control may not be standardised. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3097DOI Listing
September 2018

Whole blood exchange transfusion as a promising treatment of aluminium phosphide poisoning.

Arh Hig Rada Toksikol 2018 Sep;69(3):275-277

Department of Internal Medicine, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A 37-year-old male was referred to us about one hour after deliberate ingestion of two 3-gram aluminium phosphide (ALP) tablets. Three hours after admission, his blood pressure dropped to 85/55 mmHg, his heart rate increased to 120 bpm, O2 saturation dropped to 82 %, and the electrocardiogram showed junctional rhythm. We started whole blood exchange, and gross haematuria and jaundice ensued. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3129DOI Listing
September 2018
3 Reads

Yesterday masked, today modified; what do mycotoxins bring next?

Arh Hig Rada Toksikol 2018 Sep;69(3):196-214

Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek, Croatia.

Mycotoxins are secondary metabolites produced by toxigenic fungi in crops worldwide. In (micro)organisms such as plants, fungi, bacteria, or animals they may be further metabolised and modified, but this is also true for food processing, which may lead to a wide range of masked mycotoxin forms. These often remain undetected by analytical methods and are the culprits for underestimates in risk assessments. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3108DOI Listing
September 2018
2 Reads

Non-target toxicity of novel insecticides.

Arh Hig Rada Toksikol 2018 Jun;69(2):86-102

Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. Read More

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http://content.sciendo.com/view/journals/aiht/69/2/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3111DOI Listing
June 2018
3 Reads

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings.

Arh Hig Rada Toksikol 2018 Jun;69(2):109-125

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3118DOI Listing
June 2018
7 Reads

Levels of polychlorinated biphenyls in human milk samples in European countries.

Arh Hig Rada Toksikol 2018 Jun;69(2):135-153

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Polychlorinated biphenyls (PCBs) are persistent pollutants, harmful to human health, which enter the human body mainly through food and bind to body fat. For these reasons their use in most countries is prohibited. Human milk has an advantage over other types of human samples in measuring human exposure to PCBs, as it is obtained with non-invasive sampling methods. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3120DOI Listing
June 2018
5 Reads

Dihydroxyacetone as a definitive treatment for aluminium phosphide poisoning in rats.

Arh Hig Rada Toksikol 2018 Jun;69(2):169-177

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Aluminium phosphide (AlP), a very toxic pesticide also known as the rice tablet, releases phosphine gas upon contact with water, moisture, or gastric acid. Its mortality rate in humans is 70-100 % due to cardiogenic shock and refractory hypotension. Dihydroxyacetone (DHA) is a simple ketonic carbohydrate, mainly used for sunless skin tanning. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3106DOI Listing
June 2018
2 Reads

Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids.

Arh Hig Rada Toksikol 2018 Jun;69(2):178-185

National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia.

A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3096DOI Listing
June 2018
10 Reads

New insights into the organophosphate-induced intermediate syndrome.

Arh Hig Rada Toksikol 2018 Jun;69(2):191-195

Department of Internal Medicine and Toxicology, "Sf. Spiridon" Clinical Emergency Hospital, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Romania.

Acute organophosphate (OP) poisoning can be deadlier than any other type of chemical poisoning. So far, only a few cases have been described that include extensive neurological complications. We present an outstanding case of severe oral OP poisoning with intermediate syndrome developed on the fourth day after hospital admission. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3121DOI Listing
June 2018
18 Reads

A case of synthetic cannabinoid poisoning in Croatia.

Arh Hig Rada Toksikol 2018 Jun;69(2):186-190

Department of Pathology and Forensic Medicine, University Hospital Centre Split, Croatia.

The number of new psychoactive substances (NPS), synthetic cannabinoids (SCs) in particular, is growing constantly. Because of the insufficiently explored effects on consumer health, they have become a major problem in the emergency departments. They are difficult to identify, and there are no antidotes that could reverse their detrimental effects. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3100DOI Listing
June 2018
32 Reads

Redox imbalance caused by pesticides: a review of OPENTOX-related research.

Arh Hig Rada Toksikol 2018 Jun;69(2):126-134

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Pesticides are a highly diverse group of compounds and the most important chemical stressors in the environment. Mechanisms that could explain pesticide toxicity are constantly being studied and their interactions at the cellular level are often observed in well-controlled in vitro studies. Several pesticide groups have been found to impair the redox balance in the cell, but the mechanisms leading to oxidative stress for certain pesticides are only partly understood. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3105DOI Listing
June 2018
4 Reads

Oxidative stress, cholinesterase activity, and DNA damage in the liver, whole blood, and plasma of Wistar rats following a 28-day exposure to glyphosate.

Arh Hig Rada Toksikol 2018 Jun;69(2):154-168

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

In this 28 day-study, we evaluated the effects of herbicide glyphosate administered by gavage to Wistar rats at daily doses equivalent to 0.1 of the acceptable operator exposure level (AOEL), 0.5 of the consumer acceptable daily intake (ADI), 1. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3114DOI Listing
June 2018
8 Reads

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals.

Arh Hig Rada Toksikol 2018 Jun;69(2):103-108

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3144DOI Listing

Discrepancies in the evaluation of incapacity for work in a patient with epidermolysis bullosa acquisita between public pension fund and occupational medicine expert raise the issue of competencies.

Authors:
Hrvoje Lalić

Arh Hig Rada Toksikol 2018 Mar;69(1):77-80

1Rijeka University Faculty of Medicine, Rijeka, Croatia.

Abstrat A 50-year-old female patient suffering from a severe form of epidermolysis bullosa acquisita (EBA) took legal action against the Croatian Pension Insurance Institute (CPII) in an attempt to overturn their assessment that she was no longer capable of working as a seamstress but still capable of doing administrative jobs. Her claim was that she was not capable of doing any job at all. She was first diagnosed EBA in 2000, and the disease progressed slowly with intermittent remissions. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3072DOI Listing
March 2018
2 Reads

The efficiency of lactic acid bacteria against pathogenic fungi and mycotoxins.

Arh Hig Rada Toksikol 2018 Mar;69(1):32-45

3Department of Chemistry, Poznan University of Life Sciences, Wojska Polskiego 75, Poznań, Poland.

Mycotoxins are produced by some fungal species of the genera Aspergillus, Penicillium, and Fusarium and are common contaminants of a wide range of food commodities. Numerous strategies are used to minimise fungal growth and mycotoxin contamination throughout the food chain. This review addresses the use of lactic acid bacteria, which can inhibit fungal growth and participate in mycotoxin degradation and/or removal from contaminated food. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3051DOI Listing
March 2018
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Antimycobacterial potential of the juniper berry essential oil in tap water.

Arh Hig Rada Toksikol 2018 Mar;69(1):46-54

2Department of Microbiology and Parasitology, University of Rijeka, Rijeka, Croatia.

Mycobacterium avium complex-related diseases are often associated with poorly maintained hot water systems. This calls for the development of new control strategies. The aim of this study was to investigate the activity of essential oils (EOs) from the Mediterranean plants, common juniper, immortelle, sage, lavandin, laurel, and white cedar against Mycobacterium avium ssp. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3085DOI Listing
March 2018
3 Reads

Evaluation of breath alcohol analysers by comparison of breath and blood alcohol concentrations.

Arh Hig Rada Toksikol 2018 Mar;69(1):69-76

2Forensic Science Centre Ivan Vučetić, Ministry of the Interior, Zagreb, Croatia.

The main goal of this study was to determine the reliability of hand-held breath alcohol analysers currently approved for roadside screening of traffic offenders. The first part of the study included a retrospective data analysis of 714 offence records collected in 2011. Blood alcohol concentrations (BAC) obtained from the offenders 0-303 min after the police had screened them for breath alcohol concentration (BrAC) were back-calculated (cBAC) to assess the accuracy of breathalyser screening. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3064DOI Listing

Glutathionylation: a regulatory role of glutathione in physiological processes.

Arh Hig Rada Toksikol 2018 Mar;69(1):1-24

2PhD, Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia.

Glutathione (γ-glutamyl-cysteinyl-glycine) is an intracellular thiol molecule and a potent antioxidant that participates in the toxic metabolism phase II biotransformation of xenobiotics. It can bind to a variety of proteins in a process known as glutathionylation. Protein glutathionylation is now recognised as one of important posttranslational regulatory mechanisms in cell and tissue physiology. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-2966DOI Listing

Occupational exposure to blood and bodily fluids among healthcare workers in Serbian general hospitals.

Arh Hig Rada Toksikol 2018 Mar;69(1):61-68

4Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

The risk of occupational bloodborne infections (HBV, HCV, and HIV) among healthcare workers remains a serious issue in developing countries. The aim of this study was to estimate occupational exposure to bloodborne infections among general hospital workers in Serbia. This cross-sectional study was conducted in the spring of 2013 and included 5,247 healthcare workers from 17 general hospitals. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3047DOI Listing
March 2018
2 Reads

Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis.

Arh Hig Rada Toksikol 2018 Mar;69(1):25-31

2Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.

Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) resulting in neurological impairment and disability. There is evidence that adequate vitamin D levels may lower the risk of MS development. The aetiology of MS is complex and involves both genetic and environmental factors. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3065DOI Listing
March 2018
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Canned sea fish marketed in Serbia: their zinc, copper, and iron levels and contribution to the dietary intake.

Arh Hig Rada Toksikol 2018 Mar;69(1):55-60

3Institute of Meat Hygiene and Technology, Belgrade, Serbia.

The aim of this study was to determine the levels of Zn, Cu, and Fe in three canned fish species marketed Serbia to see if they meet recommended daily intake requirements or exceed safety limits. We collected a total of 207 samples of canned tuna, sardine, and mackerel, in oil or tomato sauce and analysed them with inductively coupled plasma mass spectrometry (ICP-MS) after acid digestion. The highest levels were obtained for Zn (15. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3069DOI Listing
March 2018
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Comparison of the solid phase and liquid-liquid extraction methods for methadone determination in human serum and whole blood samples using gas chromatography/mass spectrometry.

Arh Hig Rada Toksikol 2017 Dec;68(4):308-314

1University of Split School of Medicine, Department of Forensic Medicine, Šoltanska 2, 21000 Split, Croatia.

The aim of this study was to determine the optimal biological sample and the optimal extraction technique for monitoring methadone concentrations in biological samples. We analysed methadone in serum and whole blood samples using gas chromatography/mass spectrometry (GC/MS). Before analysis, we compared five solid-phase extraction (SPE) and two liquid-liquid extraction (LLE) methods and determined that SPE with Supelco LC-18 in serum yielded the best extraction efficiency. Read More

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http://content.sciendo.com/view/journals/aiht/68/4/article-p
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http://dx.doi.org/10.1515/aiht-2017-68-2953DOI Listing
December 2017
16 Reads

Forgotten public health impacts of cancer - an overview.

Arh Hig Rada Toksikol 2017 Dec;68(4):287-297

4Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia.

Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs). Read More

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http://dx.doi.org/10.1515/aiht-2017-68-3005DOI Listing
December 2017
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Radiological risk assessment: an overview of the ERICA Integrated Approach and the ERICA Tool use.

Arh Hig Rada Toksikol 2017 Dec;68(4):298-307

1Institute for Medical Research and Occupational Health, Zagreb, Croatia.

The ERICA project (Environmental Risk from Ionising Contaminants: Assessment and Management) was co-funded by the European Union as part of the 6th Framework Programme (FP EURATOM). The project was carried out between 2004 and 2007 as the collective work of 15 organisations in seven European countries. Two significant outputs of the project are the ERICA Integrated Approach and the ERICA Tool. Read More

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http://dx.doi.org/10.1515/aiht-2017-68-3020DOI Listing
December 2017
2 Reads