2,097 results match your criteria Arhiv za higijenu rada i toksikologiju[Journal]


Urine tropenol ester levels in workers handling tiotropium bromide synthesis: implications for exposure prevention and biomonitoring.

Arh Hig Rada Toksikol 2019 Jun;70(2):118-122

Institute of Occupational, Social and Environmental Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Tropenol ester is a highly toxic anticholinergic substance and an intermediate used in industrial production of the bronchodilator tiotropium bromide. The aim of this study was to systematically test workers involved in its production for tropenol ester in urine to identify any exposure pathways and define additional preventive measures. Twelve workers performing tasks involving potential exposure to tropenol ester were repeatedly monitored at the end of each production cycle. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3206DOI Listing
June 2019
1 Read

Management recommendations for body stuffers at emergency units.

Arh Hig Rada Toksikol 2019 Jun;70(2):90-96

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Managing body packers and stuffers is a challenge to emergency physicians, stuffers in particular, as there is no systematic approach to their treatment. The aim of this study was therefore to review all available literature on body stuffing and propose a guide to manage these patients. We searched Medline/PubMed, Google Scholar, and Scopus for published work on body stuffers using key words "body stuffer", "body stuffing", "poisoning", "toxicity", and "treatment" without a time limit and retrieved 290 articles, of which 61 remained after exclusion of those on "body packers" and repetitive documents. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3199DOI Listing
June 2019
9 Reads

Employment status and other predictors of mental health and cognitive functions in older Croatian workers.

Arh Hig Rada Toksikol 2019 Jun;70(2):109-117

Faculty of Economics and Business, University of Zagreb, Croatia.

The aim of this study was to examine mental health and cognitive functions in older Croatian workers (50-65 years) taking into account their employment status, self-assessed health, and a set of demographic characteristics. We analysed the data collected on 650 older workers (71 % employed) in the Wave 6 of the Survey of Health, Ageing and Retirement in Europe (SHARE). Unemployed workers reported symptoms of loneliness more often than the employed, while in rural areas unemployment was additionally associated with more pronounced symptoms of depression. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3254DOI Listing
June 2019
1 Read

Faecal indicator bacteria and antibiotic-resistant β-lactamase producing Escherichia coli in blackwater: a pilot study.

Arh Hig Rada Toksikol 2019 Jun;70(2):140-148

Department of Sanitary Engineering, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.

The aim of this study was to identify and quantify faecal indicator bacteria in blackwater collected from a source separation unit and determine the amount of E. coli isolates resistant to antimicrobials and their potential to produce extended spectrum β-lactamases (ESβLs) and metallo-β-lactamases (MβLs), which hydrolyse the most important antibiotics used in clinical practice. Most of the isolates were resistant to amoxicillin with clavulanic acid (36. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3212DOI Listing

Pyrethroid exposure and neurotoxicity: a mechanistic approach.

Arh Hig Rada Toksikol 2019 Jun;70(2):74-89

Student Research Committee,Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Pyrethroids are a class of synthetic insecticides that are used widely in and around households to control the pest. Concerns about exposure to this group of pesticides are now mainly related to their neurotoxicity and nigrostriatal dopaminergic neurodegeneration seen in Parkinson's disease. The main neurotoxic mechanisms include oxidative stress, inflammation, neuronal cell loss, and mitochondrial dysfunction. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3263DOI Listing
June 2019
1 Read
0.727 Impact Factor

The relationship between antioxidant activity, first electrochemical oxidation potential, and spin population of flavonoid radicals.

Authors:
Ante Miličević

Arh Hig Rada Toksikol 2019 Jun;70(2):134-139

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

I have shown that by averaging antioxidant activity (AA) values measured by different methods it is possible to obtain an excellent correlation (R2=0.960) between the first electrochemical oxidation potential, Ep1, and AA. Separate correlations using the AA values obtained with each of the four methods [R2 were 0. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3290DOI Listing
June 2019
1 Read

Determined and declared nicotine content in refill liquids for electronic cigarettes marketed in North Macedonia.

Arh Hig Rada Toksikol 2019 Jun;70(2):130-133

Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, Skopje, North Macedonia.

The use of electronic cigarettes or vaping has been gaining momentum among Macedonian smokers but has also raised great many concerns about the toxicity of liquid refills and its aerosols, especially as the nicotine levels in refill liquids (e-liquids) are not required to be declared accurately or at all by current regulations. The aim of this study was therefore to determine nicotine levels in fifteen samples of e-liquids purchased in specialised shops in Macedonia using gas chromatography. Nicotine concentrations deviated from manufacturer's declarations in nine of the twelve samples: in five they were higher and in four lower than declared, ranging from -16. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3191DOI Listing
June 2019
2 Reads

Gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol addiction: a serious health threat.

Arh Hig Rada Toksikol 2019 Jun;70(2):149-150

Department for Nephrology, Internal Clinic, University Hospital Merkur, Zagreb, Croatia.

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http://dx.doi.org/10.2478/aiht-2019-70-3295DOI Listing
June 2019
1 Read

Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation.

Arh Hig Rada Toksikol 2019 Jun;70(2):104-108

Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.

Individuals chronically exposed to low-level ionising radiation (IR) run the risk of harmful and long-term adverse health effects, including gene mutations and cancer development. The search for reliable biomarkers of IR exposure in human population is still of great interest, as they may have a great implementation potential for the surveillance of occupationally exposed individuals. In this context, and considering previous literature, this study aimed to identify mutations in the human interferon alpha-2b (hIFNα-2b) as a potential biomarker of occupational chronic low-dose IR exposure linking low-IR exposure to the effects on haematopoiesis and reduced immunity. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3202DOI Listing
June 2019
2 Reads

Dynamics of exhaled breath temperature after smoking a cigarette and its association with lung function changes predictive of COPD risk in smokers: a cross-sectional study.

Arh Hig Rada Toksikol 2019 Jun;70(2):123-129

Department of Pulmonology, University Hospital Center Osijek, Osijek, Croatia.

Exhaled breath temperature (EBT) is a biomarker of inflammation and vascularity of the airways already shown to predict incident COPD. This cross-sectional study was aimed to assess the potential of EBT in identifying "healthy" smokers susceptible to cigarette smoke toxicity of the airways and to the risk of developing COPD by analysing the dynamics of EBT after smoking a cigarette and its associations with their demographics (age, smoking burden) and lung function. The study included 55 current smokers of both sexes, 29-62 years of age, with median smoking exposure of 15 (10-71. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3211DOI Listing
June 2019
1 Read

The association between the OPRM1 A118G polymorphism and addiction in a Turkish population.

Arh Hig Rada Toksikol 2019 Jun;70(2):97-103

Gazi University, Faculty of Pharmacy Department of Toxicology, Ankara, Turkey.

Susceptibility to addiction has a complex genetic basis that includes genes associated with the action and metabolism of drugs of abuse. One important gene in that respect is OPRM1, which codes for the μ-opioid receptor and has an important role in mediating the rewarding effects of addiction substances. The aim of our study was to assess the prevalence of the OPRM1 A118G polymorphism (rs1799971) in Turkish population and to investigate its association with opioid and other substance addiction. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3153DOI Listing
June 2019
4 Reads

The role of physics in radioecology and radiotoxicology.

Arh Hig Rada Toksikol 2019 Mar;70(1):3-13

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

This article gives an overview of physical concepts important for radioecology and radiotoxicology to help bridge a gap between non-physicists in these scientific disciplines and the intricate language of physics. Relying on description and only as much mathematics as necessary, we discuss concepts ranging from fundamental natural forces to applications of physical modelling in phenomenological studies. We first explain why some atomic nuclei are unstable and therefore transmute. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3225DOI Listing
March 2019
10 Reads

Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells.

Arh Hig Rada Toksikol 2019 Mar;70(1):18-29

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA;

Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary metabolite 3,5-dimethylaminophenol (3,5-DMAP) showed that this compound causes oxidative stress, changes antioxidant enzyme activities, and leads to death of different mammalian cells. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3159DOI Listing
March 2019
3 Reads

Inspiratory muscle strength affects anaerobic endurance in professional athletes.

Arh Hig Rada Toksikol 2019 Mar;70(1):42-48

Department of Pulmonology, University Hospital Centre Osijek, Osijek, Croatia.

To the best of our knowledge, little is known about the role of respiratory muscle strength and endurance on athlete performance in anaerobic conditions of maximal exertion. The aim of this cross-sectional study was therefore to examine the association between the strength/endurance of inspiratory muscles in a group of 70 healthy male professional athletes (team sports) and their ventilatory and metabolic parameters at the anaerobic threshold (second ventilatory threshold; VT2) and beyond it at maximum load during the cardiopulmonary exercise test (CPET) on a treadmill. Ventilatory parameters at VT2, at maximal effort, and their differences were tested for association with inspiratory muscle strength (PImax) and endurance (Tlim), measured as time to maintain inspiration at or above 80% of PImax. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3182DOI Listing
March 2019
23 Reads

The effects of occupational lead exposure on selected inflammatory biomarkers.

Arh Hig Rada Toksikol 2019 Mar;70(1):36-41

Provincial Health Directorate,Malatya, Turkey.

In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-α) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-α) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3214DOI Listing
March 2019
11 Reads

The role of basic psychological needs in the perception of job insecurity.

Arh Hig Rada Toksikol 2019 Mar;70(1):54-59

University of Novi Sad, Faculty of Medicine, Department of Psychology, Novi Sad, Serbia.

The aim of this study was to investigate whether satisfied basic psychological needs reduce the perception of threat generated by job insecurity, defined as self-assessment of the availability of the working role to its performers in the foreseeable future. The study included 310 participants employed in 24 companies, who completed the Perception of Job Insecurity Scale and Need Satisfaction Scale. The hypotheses were tested with multiple regression analyses. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3156DOI Listing
March 2019
15 Reads

Inhalation poisoning with palytoxin from aquarium coral: case description and safety advice.

Arh Hig Rada Toksikol 2019 Mar;70(1):14-17

Institute of Biological Basis of Animal Production, Faculty of Biology, Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, Lublin, Poland.

Palythoa spp. corals and some other marine organisms contain one of the most poisonous substances ever known - palytoxin (PTX). Due to their modest life requirements and ease of breeding, these corals are popular in home aquariums. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3209DOI Listing
March 2019
3 Reads

The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning.

Arh Hig Rada Toksikol 2019 Mar;70(1):49-53

Toxicological Research Center, Center for Excellence in Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3162DOI Listing
March 2019
35 Reads

Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats.

Arh Hig Rada Toksikol 2019 Mar;70(1):30-35

University of Zagreb, School of Medicine, Department of Pharmacology, Zagreb, Croatia.

The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3215DOI Listing
March 2019
1 Read

Happy 70, Archives! - our mission and vision for the years to come.

Arh Hig Rada Toksikol 2019 Mar;70(1):1-2

Institute for Medical Research and Occupational Health, Zagreb, Croatia;

This year we turn 70! Lucky for journals, they don't get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you - our readers and authors - where we see Archives in the years to come. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3272DOI Listing
March 2019
3 Reads

Keeping children safe from harmful household products: a survey on safety practices in Croatia.

Arh Hig Rada Toksikol 2019 03;70(1):60-61

Institute for Medical Research and Occupational Health, Croatian Poison Control Centre, Occupational Health and Environmental Medicine Unit, Zagreb, Croatia.

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http://dx.doi.org/10.2478/aiht-2019-70-3247DOI Listing
March 2019
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Praćenje vršnog ekspiratornog protoka u dijagnozi profesionalne astme.

Arh Hig Rada Toksikol 2018 Dec;69(4):354-363

Institut za medicinska istraživanja i medicinu rada, Zagreb, Croatia.

Prema podacima iz Registra profesionalnih bolesti Hrvatskoga zavoda za zaštitu zdravlja i sigurnost na radu, u posljednjih deset godina (2008. ‒ 2017.) prijavljeno je samo 20 slučajeva profesionalne astme od ukupno 2234 prijavljene profesionalne bolesti. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3155DOI Listing
December 2018

Seasonal diversity of biodeteriogenic, pathogenic, and toxigenic constituents of airborne mycobiota in a sacral environment.

Arh Hig Rada Toksikol 2018 Dec;69(4):317-327

Department for Algology, Mycology and Lichenology, Belgrade, Serbia.

The main purpose of this study was to isolate airborne fungi and assess seasonal variations in air contamination with their particulates by determining the levels of their propagules in the nave and exonarthex of a church. We also monitored indoor microclimate as a determining factor for fungal proliferation on wall paintings, spore release, and transmission through the air. The temperature and relative humidity of the nave favoured fungal growth. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3194DOI Listing
December 2018
13 Reads

Effect of pretreatments on mycotoxin profiles and levels in dried figs.

Arh Hig Rada Toksikol 2018 Dec;69(4):328-333

Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology, Osijek, Croatia.

The aim of this explorative study was to investigate how effective drying preservation methods are in reducing mycotoxin content in figs. Dried autochthonous varieties of white and dark figs (Petrovača Bijela and Šaraguja, respectively) were analysed for mycotoxins using an LC-MS/MS "dilute and shoot" method capable of determining 295 fungal and bacterial secondary metabolites. Before drying in a cabinet dryer the figs were preserved with 0. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3147DOI Listing
December 2018
30 Reads

A unique case of a 70-hour decompression sickness latency.

Arh Hig Rada Toksikol 2018 Dec;69(4):350-353

Polyclinic Salus, Pula, Croatia.

We report a unique and well-documented case of a type II decompression sickness (DCS) with a latency interval of 70 hours. It may raise divers' awareness and help medical practitioners to keep suspect divers under close observation longer than before and identify and treat DCS accordingly. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3174DOI Listing
December 2018
6 Reads

Organic dust exposure in veterinary clinics: a case study of a small-animal practice in Portugal.

Arh Hig Rada Toksikol 2018 Dec;69(4):309-316

Health & Technology Research Center, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisboa, Portugal.

Literature about occupational health in small-animal veterinary practices is scarce, but most of it has recognised a number of risks to be considered, including organic dust exposure. The aim of this pilot study was to assess organic dust, bacterial, and fungal contamination in the indoor environment of a typical Portuguese veterinary clinic but also to screen for azoleresistant fungi. To complement these findings we also analysed workers' nasal exudates for resistant bacteriota. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3171DOI Listing
December 2018
11 Reads

Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys.

Arh Hig Rada Toksikol 2018 Dec;69(4):286-303

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Chloride/formate exchanger (CFEX; SLC26A6) mediates oxalate transport in various mammalian organs. Studies in Cfex knockout mice indicated its possible role in development of male-dominant hyperoxaluria and oxalate urolithiasis. Rats provide an important model for studying this pathophysiological condition, but data on Cfex (rCfex) localisation and regulation in their organs are limited. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3157DOI Listing
December 2018
11 Reads
0.727 Impact Factor

Residential green and blue space associated with better mental health: a pilot follow-up study in university students.

Authors:
Angel M Dzhambov

Arh Hig Rada Toksikol 2018 Dec;69(4):340-349

Department of Hygiene and Ecomedicine, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria.

Previous research has suggested that natural urban environment (green space and blue space) benefit mental health, but only a few longitudinal studies have explored the underlying mechanisms. In this pilot study we aimed to examine mechanisms/variables mediating associations between residential green/blue space and symptoms of anxiety/depression in 109 Bulgarian students from Plovdiv university. The students were followed from the beginning to the end of the school year (October 2017 to May 2018). Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3166DOI Listing
December 2018
1 Read

Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay.

Arh Hig Rada Toksikol 2018 Dec;69(4):304-308

Department of Biology and Human Genetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Harmful effects of elevated levels of catecholamines are mediated by various mechanisms, including gene transcription and formation of oxidation products. The aim of this study was to see whether the molecular mechanisms underlying the damaging action of adrenaline on DNA are mediated by reactive oxygen species (ROS). To do that, we exposed human whole blood cells to 10 μmol L-1adrenaline or 50 μmol L-1H2O2(used as positive control) that were separately pre-treated or post-treated with 500 μmol L-1of quercetin, a scavenger of free radicals. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3154DOI Listing
December 2018
2 Reads

Removing aflatoxin M1 from milk with native lactic acid bacteria, centrifugation, and filtration.

Arh Hig Rada Toksikol 2018 Dec;69(4):334-339

University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, Croatia.

In order to minimise human exposure to aflatoxin M1 (AFM1) the levels of this highly carcinogenic mycotoxin in milk, heat-treated milk, and other dairy products have been limited to <0.05 μg kg-1. However, its removal from dairy products presents a challenge for dairy producers, as commercial additives change organoleptic properties, and filtration alone yields poor results. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3160DOI Listing
December 2018
17 Reads

Sodium-glucose cotransporters: new targets of cancer therapy?

Arh Hig Rada Toksikol 2018 Dec;69(4):278-285

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3204DOI Listing
December 2018
27 Reads
0.727 Impact Factor

Urban honey - the aspects of its safety.

Arh Hig Rada Toksikol 2018 Sep;69(3):264-274

University of Belgrade Faculty of Chemistry, Belgrade, Serbia.

To contribute to the development of urban beekeeping, we designed this study to obtain more information about the contamination of urban bee products with toxic metals, polycyclic aromatic hydrocarbons (PAHs), and pesticides. The samples of honey (N=23), pollen (N=13), and floral nectar (N=6) were collected from the experimental stationary apiary of the Belgrade University Faculty of Agriculture located in centre of Zemun (a municipality of the Belgrade metropolitan area) in 2015 and 2016. Metals (Pb, Cd, As, Cu, Zn, Fe, Mn, Ni, Cr, and Hg) were determined with inductively coupled plasma quadrupole mass spectrometry (ICP-QMS). Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3126DOI Listing
September 2018
11 Reads

Employment status of workers with a diagnosed occupational disease in Croatia: a 10-year trend (2005-2014).

Arh Hig Rada Toksikol 2018 Sep;69(3):220-225

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Occupational diseases (ODs) often have a chronic, progressive course, resulting in reduced work capacity and quality of life, prolonged sick leaves, unemployment, early retirements, and disability claims. The aim of this retrospective study was to see how diagnosed ODs affected the employment of 95 Croatian workers between 2005 and 2014. To do that, we reviewed archived data and made a telephone survey. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3132DOI Listing
September 2018
3 Reads

Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure.

Arh Hig Rada Toksikol 2018 Sep;69(3):238-249

H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal.

Healthcare workers who prepare or administer cytotoxic agents run the risk of exposure, and the risks for health are real even at doses lower than those applied in cancer patients, because, in theory, no dose is safe. The most common and problematic route of exposure is through the skin, especially as work surfaces can remain contaminated even after cleaning. This pilot study aimed to demonstrate the importance of having an effective surface decontamination protocol by determining surface contamination with cyclophosphamide, 5-fluorouracil, and paclitaxel as the most common cytotoxic drugs in an oncology day service. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3137DOI Listing
September 2018
49 Reads

Occupational exposure to bioburden in Portuguese bakeries: an approach to sampling viable microbial load.

Arh Hig Rada Toksikol 2018 Sep;69(3):250-257

Health & Technology Research Centre, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal.

In bakeries, a number of operations such as mixing are associated with exposure to air-suspended flour dust and related bioburden. The aim of this study was to find the best active sampling approach to the assessment of occupational exposure to bioburden in Portuguese bakeries based on the data obtained with the use of specific impaction and impinger devices. We used impaction to collect fungal particles from 100 L air samples onto malt extract agar (MEA) supplemented with chloramphenicol (0. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3116DOI Listing
September 2018
3 Reads

Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants.

Arh Hig Rada Toksikol 2018 Sep;69(3):215-219

Institute for Medical Research, Division of Clinical & Experimental Immunology, Military Medical Academy School of Medicine, Belgrade, Serbia.

Clara cell protein 16 (CC16) is a small protein mainly produced by non-ciliated Clara cells in the respiratory epithelium. It has an anti-inflammatory role in chronic upper and lower airway eosinophilic inflammations. Decreased levels of CC16 are found in the nasal secretions and plasma of patients with chronic eosinophilic inflammatory disorders, such as asthma, allergic rhinitis, and chronic rhinosinusitis with or without nasal polyps, as well as in people exposed to high levels of air pollutants. Read More

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http://content.sciendo.com/view/journals/aiht/69/3/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3081DOI Listing
September 2018
3 Reads

A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments.

Arh Hig Rada Toksikol 2018 Sep;69(3):226-237

Careggi University Hospital, Medicina del Lavoro - Laboratorio di Igiene e Tossicologia Industriale, Florence, Italy.

Cytotoxic antineoplastic drugs (ADs) pose occupational risk and therefore require safe handling practices. We created, optimised, and validated an innovative monitoring protocol for simultaneously assessing 21 ADs in the healthcare environment, and also proposed surface exposure levels (SELs) to facilitate the interpretation of monitoring results, as there are currently no occupational exposure limits for ADs. The environmental AD monitoring data were collected in nine Italian hospitals between 2008 and 2017 and include 74,565 measurements in 4,814 wipe samples. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3125DOI Listing
September 2018
4 Reads

How sulphur dioxide and storage temperature contribute to patulin degradation in homemade apple juice.

Arh Hig Rada Toksikol 2018 Sep;69(3):258-263

Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia.

Mycotoxin patulin is one of the quality indicators for apple juice. Like other mycotoxins, it raises consumer health concerns. The issue of low quality is particularly relevant for apples provided by small producers, whose quality control may not be standardised. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3097DOI Listing
September 2018
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Whole blood exchange transfusion as a promising treatment of aluminium phosphide poisoning.

Arh Hig Rada Toksikol 2018 Sep;69(3):275-277

Department of Internal Medicine, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A 37-year-old male was referred to us about one hour after deliberate ingestion of two 3-gram aluminium phosphide (ALP) tablets. Three hours after admission, his blood pressure dropped to 85/55 mmHg, his heart rate increased to 120 bpm, O2 saturation dropped to 82 %, and the electrocardiogram showed junctional rhythm. We started whole blood exchange, and gross haematuria and jaundice ensued. Read More

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http://content.sciendo.com/view/journals/aiht/69/3/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3129DOI Listing
September 2018
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Yesterday masked, today modified; what do mycotoxins bring next?

Arh Hig Rada Toksikol 2018 Sep;69(3):196-214

Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek, Croatia.

Mycotoxins are secondary metabolites produced by toxigenic fungi in crops worldwide. In (micro)organisms such as plants, fungi, bacteria, or animals they may be further metabolised and modified, but this is also true for food processing, which may lead to a wide range of masked mycotoxin forms. These often remain undetected by analytical methods and are the culprits for underestimates in risk assessments. Read More

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http://content.sciendo.com/view/journals/aiht/69/3/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3108DOI Listing
September 2018
3 Reads

Non-target toxicity of novel insecticides.

Arh Hig Rada Toksikol 2018 Jun;69(2):86-102

Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. Read More

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http://content.sciendo.com/view/journals/aiht/69/2/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3111DOI Listing
June 2018
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Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings.

Arh Hig Rada Toksikol 2018 Jun;69(2):109-125

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3118DOI Listing
June 2018
9 Reads

Levels of polychlorinated biphenyls in human milk samples in European countries.

Arh Hig Rada Toksikol 2018 Jun;69(2):135-153

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Polychlorinated biphenyls (PCBs) are persistent pollutants, harmful to human health, which enter the human body mainly through food and bind to body fat. For these reasons their use in most countries is prohibited. Human milk has an advantage over other types of human samples in measuring human exposure to PCBs, as it is obtained with non-invasive sampling methods. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3120DOI Listing
June 2018
7 Reads

Dihydroxyacetone as a definitive treatment for aluminium phosphide poisoning in rats.

Arh Hig Rada Toksikol 2018 Jun;69(2):169-177

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Aluminium phosphide (AlP), a very toxic pesticide also known as the rice tablet, releases phosphine gas upon contact with water, moisture, or gastric acid. Its mortality rate in humans is 70-100 % due to cardiogenic shock and refractory hypotension. Dihydroxyacetone (DHA) is a simple ketonic carbohydrate, mainly used for sunless skin tanning. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3106DOI Listing
June 2018
4 Reads

Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids.

Arh Hig Rada Toksikol 2018 Jun;69(2):178-185

National Poison Control Centre, Military Medical Academy, Medical Faculty University of Defense, Belgrade, Serbia.

A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3096DOI Listing
June 2018
28 Reads

New insights into the organophosphate-induced intermediate syndrome.

Arh Hig Rada Toksikol 2018 Jun;69(2):191-195

Department of Internal Medicine and Toxicology, "Sf. Spiridon" Clinical Emergency Hospital, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Romania.

Acute organophosphate (OP) poisoning can be deadlier than any other type of chemical poisoning. So far, only a few cases have been described that include extensive neurological complications. We present an outstanding case of severe oral OP poisoning with intermediate syndrome developed on the fourth day after hospital admission. Read More

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http://content.sciendo.com/view/journals/aiht/69/2/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3121DOI Listing
June 2018
52 Reads

A case of synthetic cannabinoid poisoning in Croatia.

Arh Hig Rada Toksikol 2018 Jun;69(2):186-190

Department of Pathology and Forensic Medicine, University Hospital Centre Split, Croatia.

The number of new psychoactive substances (NPS), synthetic cannabinoids (SCs) in particular, is growing constantly. Because of the insufficiently explored effects on consumer health, they have become a major problem in the emergency departments. They are difficult to identify, and there are no antidotes that could reverse their detrimental effects. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3100DOI Listing
June 2018
60 Reads

Redox imbalance caused by pesticides: a review of OPENTOX-related research.

Arh Hig Rada Toksikol 2018 Jun;69(2):126-134

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Pesticides are a highly diverse group of compounds and the most important chemical stressors in the environment. Mechanisms that could explain pesticide toxicity are constantly being studied and their interactions at the cellular level are often observed in well-controlled in vitro studies. Several pesticide groups have been found to impair the redox balance in the cell, but the mechanisms leading to oxidative stress for certain pesticides are only partly understood. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3105DOI Listing
June 2018
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Oxidative stress, cholinesterase activity, and DNA damage in the liver, whole blood, and plasma of Wistar rats following a 28-day exposure to glyphosate.

Arh Hig Rada Toksikol 2018 Jun;69(2):154-168

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

In this 28 day-study, we evaluated the effects of herbicide glyphosate administered by gavage to Wistar rats at daily doses equivalent to 0.1 of the acceptable operator exposure level (AOEL), 0.5 of the consumer acceptable daily intake (ADI), 1. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3114DOI Listing
June 2018
12 Reads

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals.

Arh Hig Rada Toksikol 2018 Jun;69(2):103-108

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3144DOI Listing
June 2018
1 Read