565 results match your criteria Argyria

Systemic argyria with severe anemia (hemoglobin 2.4 g/L).

Proc (Bayl Univ Med Cent) 2022 18;35(3):382-384. Epub 2022 Jan 18.

Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas.

Argyria is a rare disease in which chronic usage of products with a high silver content leads to deposition of silver granules in organs such as the skin, resulting in a permanent blue-gray discoloration. We present a 68-year-old woman with a 10-year history of chronic anemia of unknown etiology who was admitted for progressive generalized weakness, dyspnea, and a widespread slate-gray tint to her skin. She had previously consumed 1 tablespoon per day of colloidal silver orally for 7 years. Read More

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January 2022

Complex management of lentigo maligna in the setting of chrysiasis, argyriasis, and tattoo using in vivo reflectance confocal microscopy.

J Dermatol 2022 May 5. Epub 2022 May 5.

The Melanoma Institute of Australia, New South Wales, Australia.

Lentigo maligna (LM) can be difficult to diagnose and recurrence is not uncommon. In vivo reflectance confocal microscopy (RCM) improves diagnostic accuracy of LM. LM can be difficult to discern from coexistent metal-induced cutaneous hyperpigmentation (MICH). Read More

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Local Argyria due to Silver-Coated Megaprosthesis.

Am J Med 2022 Jun 5;135(6):e116. Epub 2022 Feb 5.

Orthopedic Surgery Department, Limoges Teaching Hospital, Limoges, France.

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Graphite Foreign Body Misdiagnosed as a Blue Naevus-Like Localised Argyria.

Anushka Sharma

Clin Cosmet Investig Dermatol 2021 16;14:1253-1256. Epub 2021 Sep 16.

Institute of Clinical Sciences, Imperial College School of Medicine, London, UK.

Pencil-tip injuries, although usually insignificant, have the potential to provoke granulomatous reactions. Other undesirable consequences of such injuries include pigmentation and abscess formation. Despite the rarity of such outcomes, it is important that clinicians are aware of the varying presentations of pencil-tip injury, as this can cause diagnostic uncertainty. Read More

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September 2021

[Ocular argyria after long-term application of eyelash and eyebrow tints].

Ophthalmologe 2021 Sep 17. Epub 2021 Sep 17.

Klinik für Augenheilkunde, Universitätsklinikum Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

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September 2021

Distribution, metabolism, excretion, and toxicity of implanted silver: a review.

Drug Chem Toxicol 2021 Aug 30:1-10. Epub 2021 Aug 30.

Division for Food Technology, Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark, Lyngby, Denmark.

Some implantable medical devices contain silver. We aimed to assess at what amount implanted silver becomes toxic. Silver was elevated in bodily fluids and tissues surrounding silver-containing implants. Read More

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Argyria From a Topical Home Remedy.

Cutis 2021 06;107(6):E10-E11

Dr. Reader is from St. Joseph Mercy Health System, Ypsilanti, Michigan. Drs. Dillon and Halleman are from Largo Medical Center, Florida.

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When self-medication goes wrong: the case of argyria at the Padua Morgagni Museum of Pathology.

Virchows Arch 2022 Jun 9;480(6):1283-1288. Epub 2021 Jul 9.

University Museums Centre CAM, University of Padua, Via A. Gabelli, 61, 35121, Padua, Italy.

A unique specimen of argyria is preserved in the Morgagni Museum of Pathological Anatomy at the University of Padua (Italy). It is a stuffed head belonging to a man who decided to cure his syphilis by himself with the so-called infernal stone (silver nitrate) every day for years, thus developing argyria in the second half of the nineteenth century. Paleopathological and historical studies were performed on the specimen to confirm the diagnosis of argyria. Read More

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Localized cutaneous argyria: Review of a rare clinical mimicker of melanocytic lesions.

Ann Diagn Pathol 2021 Oct 26;54:151776. Epub 2021 Jun 26.

Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. Electronic address:

Localized cutaneous argyria is a rare cutaneous disorder that has been associated with occupational exposure, dental procedures, topical agents, acupuncture, earrings, and nasal piercings. In this paper, we review the current literature on localized cutaneous argyria, highlight its clinical and histologic diagnostic features, and then discuss the clinical and histological differential diagnoses for blue-gray skin and black dermal pigment, respectively. We also discuss the utility of ancillary techniques, such as deeper histologic levels, special stains, darkfield microscopy, and advanced micro-analytical techniques in helping diagnose localized cutaneous argyria. Read More

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October 2021

Exogenous pigmentation by silver nitrate: Dermatological and toxicological aspects, case report

Biomedica 2021 06 29;41(2):234-239. Epub 2021 Jun 29.

Grupo de Investigación, Universidad CES, Medellín, Colombia.

Exogenous pigmentation by silver nitrate is a rare disease whose clinical manifestations appear even years after the contact, making its diagnosis difficult on occasions. It is characterized by the presence of blue-gray macules or plaques on the skin or mucosa in the contact area, sometimes very similar to melanocytic lesions and melanoma, which constitute the main differential diagnosis. We report the case of a male patient from Medellín, Colombia, with a family history of melanoma and the presence of these lesions throughout his body. Read More

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Clinical and Forensic Aspects of the Different Subtypes of Argyria.

J Clin Med 2021 May 13;10(10). Epub 2021 May 13.

Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.

Argyria encompasses the different cosmetic alterations that can develop if enough silver particles deposit in a specific tissue, typically in the skin, ranging from localized dark-blue macules to a generalized slate-gray/bluish tinge following systemic absorption. This work aims to fully review the state of the art regarding pathophysiology, diagnosis, treatment, and relevant clinical and forensic features of argyria. Argyria has been diagnosed in a wide range of ages, both sexes and varied ethnicities, with no known individual predisposing factors. Read More

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The role of silver coating for arthroplasty components.

Bone Joint J 2021 Mar;103-B(3):423-429

Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.

Periprosthetic joint infection (PJI) is one of the most dreaded complications after arthroplasty surgery; thus numerous approaches have been undertaken to equip metal surfaces with antibacterial properties. Due to its antimicrobial effects, silver is a promising coating for metallic surfaces, and several types of silver-coated arthroplasty implants are in clinical use today. However, silver can also exert toxic effects on eukaryotic cells both in the immediate vicinity of the coated implants and systemically. Read More

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Occupational Localized Cutaneous Argyria With Pseudo-Ochronosis in a Jeweler.

Am J Dermatopathol 2021 Nov;43(11):822-826

Department of Dermatopathology, St George's University Hospital, London, United Kingdom.

Abstract: A case of localized argyria in a 36-year-old female jeweler is described who presented with 2 discrete and asymptomatic bluish-black pigmented macules on the pulp of her left middle finger. A skin biopsy from both lesions demonstrated deposition of brown/black pigmented granules along the basement membrane zone of eccrine glands, blood vessels, nerves, and the dermo-epidermal junction fully in keeping with silver deposition. In addition, there was yellow-brown deposition seen within the interstitial dermis mimicking an early form of ochronosis, so called "pseudo-ochronosis. Read More

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November 2021

Silver in biology and medicine: opportunities for metallomics researchers.

Metallomics 2021 01;13(1)

Department of Chemistry, The University of Adelaide, North Terrace, SA 5005, Australia.

The antibacterial properties of silver have been known for centuries and the threat of antibiotic-resistant bacteria has led to renewed focus on the noble metal. Silver is now commonly included in a range of household and medical items to imbue them with bactericidal properties. Despite this, the chemical fate of the metal in biological systems is poorly understood. Read More

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January 2021

[Neurological patient with greyblue skin colour of unknown origin].

Dtsch Med Wochenschr 2021 01 19;146(2):73-74. Epub 2021 Jan 19.

Abteilung für Pneumologie und Infektiologie, Christliches Krankenhaus Quakenbrück GmbH, Quakenbrück.

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January 2021

Toxicity of colloidal silver products and their marketing claims in Finland.

Toxicol Rep 2021 26;8:106-113. Epub 2020 Dec 26.

School of Pharmacy/Toxicology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Aims: The aim was to investigate the marketing practices, beliefs and health claims regarding the use of colloidal silver in Finland. Silver nanoparticles (AgNPs) are potentially toxic due to their small size and Ag-release capabilities, and the use of colloidal silver products containing AgNPs can cause a wide variety of adverse effects such as argyria.

Methods: Contents of three company websites selling colloidal silver were reviewed, and the claims used in the marketing of colloidal silver were compared to the scientific information about silver. Read More

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December 2020

Argyria: a cause of pseudocyanosis.

QJM 2021 08;114(5):341

Catholic Health System, Sisters of Charity Hospital, University at Buffalo, Buffalo, NY 14214, USA.

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Generalized Argyria Successfully Treated with Q-switched Alexandrite Laser: A Case Report.

Acta Derm Venereol 2020 Dec 14;100(19):adv00348. Epub 2020 Dec 14.

Department of Dermatology, Graduate School of Medicine, the University of Tokyo, 113-8655 Tokyo, Japan.

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December 2020

Localized argyria with pseudo-ochronosis.

J Cutan Pathol 2020 08;47(8):671-674

Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

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Successful treatment of acupuncture-induced argyria using Q-switched 1064-nm Nd:YAG laser.

JAAD Case Rep 2020 Oct 3;6(10):984-987. Epub 2020 Aug 3.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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October 2020

Occurrence of primary progressive multiple sclerosis in a patient with argyria: Causality or coincidence?

Mult Scler Relat Disord 2020 Nov 31;46:102465. Epub 2020 Aug 31.

Department of Ophthalmology Tübingen, University of Tübingen, Tübingen, Germany.

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November 2020

Silver-coated megaprosthesis in prevention and treatment of peri-prosthetic infections: a systematic review and meta-analysis about efficacy and toxicity in primary and revision surgery.

Eur J Orthop Surg Traumatol 2021 Feb 5;31(2):201-220. Epub 2020 Sep 5.

Azienda ospedaliera Sant'Orsola Malpighi, Bologna, Italy.

Aim: Prosthetic joint infection (PJI) is a common complication following orthopedic megaprosthetic implantations (EPR), estimated up to 50%. Silver coatings were introduced in order to reduce the incidence of PJI, by using the antibacterial activity of silver. Three different silver coatings are available: MUTARS (Implantcast), Agluna (Accentus Medical), PorAg (Waldemar Link). Read More

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February 2021

A clinical mimicker of melanoma with distinctive histopathology: Topical silver nitrate exposure.

J Cutan Pathol 2020 Dec 15;47(12):1205-1210. Epub 2020 Sep 15.

Dartmouth-Hitchcock Medical Center, Department of Pathology and Laboratory Medicine, Lebanon, New Hampshire, USA.

Exposure to silver-containing compounds can result in reversible discoloration of the skin, presenting as an irregular brown or black macule, which can have a clinical appearance similar to melanoma. Both the clinical scenario and the histopathology are unique. Silver nitrate darkens with exposure to light, and the area can appear to change over time. Read More

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December 2020

Argyria, an Unexpected Case of Skin Discoloration From Colloidal Silver Salt Ingestion.

J Emerg Med 2020 Aug 23;59(2):e39-e41. Epub 2020 Jun 23.

Department of Emergency Medicine, Denver Health, Denver, Colorado.

Background: Argyria is a rare condition characterized by gray/blue dislocation of the skin caused by chronic exposure to silver salts.

Case Report: We review the case of an 81-year-old man who presented to the emergency department after a motor vehicle accident, was incidentally found to have skin discoloration, and was ultimately diagnosed with argyria. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Although most emergency physicians will not complete a toxicology fellowship, all emergency physicians are on the front line of toxicological presentations and should be able to recognize argyria and differentiate this condition from other causes of skin discoloration. Read More

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Effective laser treatment options for argyria: Review of literatures.

J Cosmet Dermatol 2020 Aug 3;19(8):1877-1882. Epub 2020 Jul 3.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Argyria results from silver accumulation in the skin. It is a stressful condition for patients due to skin discoloration. In the past, no effective treatments were available. Read More

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Phomopsidione-Loaded Chitosan Polyethylene Glycol (PEG) Nanocomposite Dressing for Pressure Ulcers.

J Pharm Sci 2020 09 11;109(9):2884-2890. Epub 2020 Jun 11.

Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

Pressure ulcers are commonly associated with microbial infections on the wounds which require an effective wound dressing for treatment. Thus far, the available silver dressing has shown tremendous result, however, it may cause argyria and complicate the internal organ function. Hence, our study aims to develop and characterize phomopsidione-loaded chitosan-polyethylene glycol nanocomposite hydrogel (C/PEG/Ph) as an antimicrobial dressing. Read More

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September 2020

Pulmonary toxicity of silver vapours, nanoparticles and fine dusts: A review.

Regul Toxicol Pharmacol 2020 Aug 28;115:104690. Epub 2020 May 28.

National Research Centre for the Working Environment, DK, 2100, Copenhagen, Denmark. Electronic address:

Silver is used in a wide range of products, and during their production and use, humans may be exposed through inhalation. Therefore, it is critical to know the concentration levels at which adverse effects may occur. In rodents, inhalation of silver nanoparticles has resulted in increased silver in the lungs, lymph nodes, liver, kidney, spleen, ovaries, and testes. Read More

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PBPK Modeling of Slightly Soluble Silver Nanomaterials and Regulatory Acceptance.

Small 2020 09 25;16(36):e1907667. Epub 2020 May 25.

Pennsylvania Bio Nano Systems, LLC, 69 Homestead Drive, Doylestown, PA, 18901, USA.

International efforts to promote predictive toxicology incorporate some form of modeling based on the regularities, insights, and hypotheses gained from analyzing laboratory studies compiled in databases. While there has been a broad commentary on definitions, metadata, and test methodologies, all necessary to establishing data repositories, there has been less on translating the resulting insights into computational models. The recent use of a computational model to support a recommended exposure limit for nanoparticulate silver is an opportunity to examine physiologically based toxicokinetics in terms of data availability, model verification and validation, and regulatory acceptance. Read More

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September 2020

In vitro intestinal toxicity of commercially available spray disinfectant products advertised to contain colloidal silver.

Sci Total Environ 2020 Aug 14;728:138611. Epub 2020 Apr 14.

National Institute for Occupational Safety and Health, Morgantown, WV 26506, United States.

The use of colloidal silver-containing products as dietary supplements, immune boosters and surface disinfectants has increased in recent years which has elevated the potential for human exposure to silver nanoparticles and ions. Product mislabeling and long-term use of these products may put consumers at risk for adverse health outcomes including argyria. This study assessed several physical and chemical characteristics of five commercial products as well as their cytotoxicity using a rat intestinal epithelial cell (IEC-6) model. Read More

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