Search Our Scientific Publications & Authors

Eye (Lond) 2019 01 22;33(1):110-119. Epub 2018 Nov 22.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

Acute primary angle closure requires emergency management that involves a rapid lowering of the intraocular pressure and resolution of relative pupil block - the most common mechanism of angle closure. Emergency strategies for lowering intraocular pressure include medical treatment and argon laser peripheral iridoplasty. Anterior chamber paracentesis and diode laser transcleral cyclophotocoagulation may be considered in special situations. Read More

Ophthalmology 2019 Feb 29;126(2):223-232. Epub 2018 Sep 29.

Department of Ophthalmology, Western University, Ontario, Canada. Electronic address:

Purpose: The effectiveness of selective laser trabeculoplasty (SLT) was compared with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically uncontrolled open-angle glaucoma who have previously received 360° SLT.

Design: An active equivalence parallel armed randomized control trial.

Participants: Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syndrome were enrolled into the study from 7 different sites across Canada. Read More

Clin Ophthalmol 2018 6;12:1359-1365. Epub 2018 Aug 6.

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan,

Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan.

Study Design: A single-center, retrospective case series.

Methods: We retrospectively reviewed all medical records of bullous keratopathy (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Read More

Acta Ophthalmol 2018 Aug 14;96(5):e582-e591. Epub 2018 Apr 14.

Department of Ophthalmology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Purpose: To report on the efficacy and safety of CO laser-assisted sclerectomy surgery (CLASS) compared with trabeculectomy in primary open-angle glaucoma and exfoliative glaucoma.

Methods: One hundred and thirty-one patients underwent CLASS (66 patients) or trabeculectomy (65 patients) and were followed up for 12 months. 'Complete success' was defined as intraocular pressure (IOP) between 10 and 18 mmHg and reduced by at least 30% from the baseline without medications, while 'qualified success' was compliant with the above criteria with or without the medications. Read More

Adv Ther 2018 May 11;35(5):619-630. Epub 2018 Apr 11.

Department of Ophthalmology, Hospital Universitario "Principe de Asturias," Universidad de Alcalá, Alcalá de Henares, Spain.

In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. Read More

Klin Monbl Augenheilkd 2018 Apr 11. Epub 2018 Apr 11.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg.

Background: Laser trabeculoplasty (LTP) is a well established treatment modality in the management of chronic open angle glaucoma. Nonetheless there is much variation in practice.

Methods: A literature search in the PubMed database was conducted and the most important evidence-based results were summarised. Read More

Ghana Med J 2017 Dec;51(4):175-180

Department of Ophthalmology, University of Ibadan College of Medicine, Ibadan, Oyo, Nigeria.

Aim: To report the safety and efficacy of Argon Laser Trabeculoplasty (ALT) in reducing intraocular pressure (IOP).

Settings And Design: This was a retrospective study performed on 25 eyes of 25 patients.

Methods And Materials: Consecutive patients who met the inclusion criteria for ALT were recruited from the ophthalmic clinic of the University College Hospital Ibadan, Nigeria and followed up for a minimum period of six months. Read More

Rom J Ophthalmol 2017 Apr-Jun;61(2):117-122

"Gr. T. Popa" University of Medicine and Pharmacy, Iași, Romania.

We present the therapeutic options and functional results in patients with plateau iris (syndrome or configuration) in consecutive case series. Our study included newly diagnosed patients with acute angle closure by "plateau iris" (configuration or syndrome), between June 2016 and April 2017. Series of 8 consecutive patients met the inclusion criteria, all being females. Read More

Can J Ophthalmol 2018 02 27;53(1):70-75. Epub 2017 Sep 27.

Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, N.S.

Objective: Laser trabeculoplasty effectively reduces intraocular pressure (IOP) in primary open angle glaucoma, with argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) showing equivalent outcomes. However, it is unclear which laser modality is more effective in pseudoexfoliation (PXE) glaucoma. This study aims to compare the effectiveness of ALT and SLT in PXE glaucoma. Read More

J Glaucoma 2018 Jul;27 Suppl 1:S91-S94

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB, Canada.

Argon laser trabeculoplasty as well as selective laser trabeculoplasty can be used in patients with exfoliation syndrome with similar safety and efficacy. However, treatment effect may abruptly reverse and patients need to be followed regularly to monitor intraocular pressure control. Newer laser treatment modalities including micropulse laser trabeculoplasty, titanium sapphire laser trabeculoplasty and pattern scanning trabeculoplasty show promising results but need to be studied in exfoliation patients. Read More

Eye (Lond) 2018 05 5;32(5):863-876. Epub 2018 Jan 5.

Department of Glaucoma, Moorfields Eye Hospital, London, UK.

Over the past two decades, selective laser trabeculoplasty (SLT) has increasingly become an established laser treatment used to lower intraocular pressure in open-angle glaucoma and ocular hypertensive patients. In this review we trace the origins of SLT from previous argon laser trabeculoplasty and review the current role it has in clinical practice. We outline future directions of SLT research and introduce emerging technologies that are further developing this intervention in the treatment paradigm of glaucoma. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Jan 17;256(1):181-186. Epub 2017 Nov 17.

Clinica Oculistica Università di Genova DiNOGMI - Ospedale Policlinico San Martino, Viale Benedetto XV, 5, 16136, Genoa, Italy.

Purpose: Our purpose was to evaluate the clinical safety and efficacy of CO laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG).

Methods: This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. Read More

Eur J Ophthalmol 2018 Jan;28(1):119-122

1 Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA.

Purpose: To provide a clinical description of the long-term outcome of a Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.

Methods: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. Read More

J Cataract Refract Surg 2017 Jul;43(7):886-891

From the Dipartimento di Scienze Chirurgiche (Fea), Clinica Oculistica di Torino, Torino, Italy; the Department of Ophthalmology (Rekas), Military Institute of Medicine, Warsaw, Poland; the Manchester Royal Eye Hospital (Au), Central Manchester Foundation Trust, Manchester, United Kingdom.

Purpose: To evaluate the efficacy and the safety of a new Schlemm canal scaffold microstent (Hydrus) combined with cataract surgery in routine clinical practice.

Settings: Clinics in Italy, Poland, and the United Kingdom.

Design: Retrospective case series. Read More

Klin Monbl Augenheilkd 2017 Nov 28;234(11):1362-1371. Epub 2017 Jun 28.

Augenheilkunde, Tagesklinik Ambimed, Basel, Schweiz.

Worldwide, in recent years, selective laser trabeculoplasty (SLT) has developed into a very successful therapy for glaucoma. The article provides a review of the literature from PubMed and clinical experience. SLT is equally efficacious to argon laser trabeculoplasty (ALT) and to a first-line glaucoma medication. Read More

Cochrane Database Syst Rev 2017 02 23;2:CD010746. Epub 2017 Feb 23.

Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, Michigan, USA, 48105.

Background: Glaucoma is the international leading cause of irreversible blindness. Intraocular pressure (IOP) is the only currently known modifiable risk factor; it can be reduced by medications, incisional surgery, or laser trabeculoplasty (LTP). LTP reduces IOP by 25% to 30% from baseline, but early acute IOP elevation after LTP is a common adverse effect. Read More

Medicine (Baltimore) 2016 Dec;95(52):e5745

aStatistics Department and Public Health Department, Federal University of Juiz de Fora bOphthalmology Department, Santa Casa de Misericórdia Hospital cGlaucoma Department, Paletta Guedes Ophthalmological Center, Juiz de Fora, MG, Brazil.

Background: The aim of this study is to determine the most cost-effective strategy for the treatment of primary open-angle glaucoma (POAG) in Brazil, from the payer's perspective (Brazilian Public Health System) in the setting of the Glaucoma Referral Centers.

Methods: Study design was a cost-effectiveness analysis of different treatment strategies for POAG. We developed 3 Markov models (one for each glaucoma stage: early, moderate and advanced), using a hypothetical cohort of POAG patients, from the perspective of the Brazilian Public Health System (SUS) and a horizon of the average life expectancy of the Brazilian population. Read More

Int J Ophthalmol 2016 18;9(11):1684-1690. Epub 2016 Nov 18.

Department of Ophthalmology, V.M.M.C & Safdarjung Hospital, Newdelhi 110029, India.

The treatment of glaucoma in and around pregnancy offers the unique challenge of balancing the risk of vision loss to the mother as against the potential harm to the fetus or newborn. Most anti-glaucoma drugs ( beta-blockers, prostaglandin analogues, carbonic anhydrase inhibitors topical and systemic, cholinergics, anticholinesterases, and apraclonidine) are considered category C agents and ophthalmologists are usually limited to treating patients with the category B drugs of brimonidine and dipivefrin. Brimonidine is generally the preferred first-line drug in the first, second and early third trimester. Read More

Semin Ophthalmol 2018 14;33(2):260-264. Epub 2016 Dec 14.

a Mayo Clinic Department of Ophthalmology , Rochester , MN , USA.

Purpose: To describe IOL haptic with iris or ciliary body touch on ultrasound biomicroscopy (UBM) in pseudophakic patients with unexplained recurrent hyphema or vitreous hemorrhage.

Methods: Retrospective chart review of 10 patients who presented with unexplained recurrent hyphema and or vitreous hemorrhage.

Results: There were eight posterior chamber intraocular lenses (PCIOL) and two sulcus lenses. Read More

Turk J Ophthalmol 2016 Jan 5;46(1):38-40. Epub 2016 Jan 5.

Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey.

We present a case of transpupillary argon laser cyclophotocoagulation (TALC) in a patient with traumatic aniridia and aphakia secondary to blunt trauma who had previous bilateral trabeculectomy. Four months after the trauma the patient's intraocular pressure (IOP) rose to 35 mmHg despite topical antiglaucomatous medication. Inferior 180 degrees cyclophotocoagulation was performed with transpupillary argon laser in the first session and his IOP fell to values of 12-17 mmHg. Read More

Ophthalmology 2016 10 29;123(10):2085-92. Epub 2016 Aug 29.

Departments of Anesthesia and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To assess the ability of latanoprost-eluting contact lenses to lower the intraocular pressure (IOP) of glaucomatous eyes of cynomolgus monkeys.

Design: Preclinical efficacy study of 3 treatment arms in a crossover design.

Participants: Female cynomolgus monkeys with glaucoma induced in 1 eye by repeated argon laser trabeculoplasty. Read More

Invest Ophthalmol Vis Sci 2016 Apr;57(4):2012-20

Orthoptics and Visual Science, Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.

Purpose: To develop a large-scale real clinical database of glaucoma (Japanese Archive of Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect of treatment.

Methods: The study included a total of 1348 eyes of 805 primary open-angle glaucoma patients with 10 visual fields (VFs) measured with 24-2 or 30-2 Humphrey Field Analyzer (HFA) and intraocular pressure (IOP) records in 10 institutes in Japan. Those with 10 reliable VFs were further identified (638 eyes of 417 patients). Read More

Eye Vis (Lond) 2016 5;3:10. Epub 2016 Apr 5.

Department of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium ; Department of Ophthalmology, University Hospital Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium.

Background: Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma medication. We wondered if selective laser trabeculoplasty (SLT) could be a useful alternative.

Methods:

Inclusion Criteria: controlled trials comparing efficacy of SLT in adult patients with any form of open angle glaucoma or ocular hypertension and case reports on side effects of SLT. Read More

Open Ophthalmol J 2016 29;10:56-67. Epub 2016 Feb 29.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA.

There has been tremendous progress in the past decades in the utilization of lasers for treating patients with glaucoma. This article reviews the use of lasers in different areas of glaucoma, including the shift from argon laser trabeculoplasty (ALT) to selective laser trabeculoplasty (SLT), laser trabeculoplasty as an initial treatment for glaucoma, new laser trabeculoplasty procedures under investigation, and other recent laser treatment modalities such as endoscopic cyclophotocoagulation and laser-assisted deep sclerectomy. Read More

Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):63-9

From the University of Colorado School of Medicine, Department of Ophthalmology, Aurora, CO.

Selective laser trabeculoplasty (SLT) is an effective treatment option for the reduction of intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma. The mechanism by which SLT lowers IOP is not completely understood and is likely multifactorial. Published studies indicate that SLT is at least as effective as argon laser trabeculoplasty or medications at lowering IOP in many forms of glaucoma. Read More

Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):59-62

From the Department of Ophthalmology, The University of Hong Kong, Hong Kong, China.

Primary angle-closure glaucoma (PACG) is a progressive optic nerve degeneration and is defined as a glaucomatous optic neuropathy with associated characteristic enlargement of optic disc cupping and visual field loss that is secondary to ocular hypertension caused by closure of the drainage angle. Angle closure is caused by appositional approximation or adhesion between the iris and the trabecular meshwork. The main treatment strategy for PACG lies in the reduction of intraocular pressure, reopening of the closed angle, and possible prevention of further angle closure. Read More

PLoS One 2016 25;11(1):e0147963. Epub 2016 Jan 25.

Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwang-ju, Republic of Korea.

Purpose: To investigate the effect of argon laser trabeculoplasty (ALT) on posture-induced intraocular pressure (IOP) changes in patients with open angle glaucoma (OAG).

Methods: Thirty eyes of 30 consecutive patients with OAG who underwent ALT were prospectively analyzed. The IOP was measured using Icare PRO in the sitting position, supine position, and dependent lateral decubitus position (DLDP) before ALT and at 1 week, 1 month, 2 months, and 3 months after ALT. Read More

J Ophthalmol 2015 29;2015:370371. Epub 2015 Oct 29.

Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.

Pseudoexfoliation syndrome (PES) is a systemic disorder caused by progressive accumulation of extracellular material over various tissues. PES usually determines increased intraocular pressure, changes in the anatomical aspects of the optic nerve, and visual field alterations leading to the diagnosis of pseudoexfoliation glaucoma (PEG). Use of topical medical treatment usually leads to poor results in terms of long-term follow-up but many surgical techniques, such as Argon Laser or Selective Laser Trabeculoplasty, have been proposed for the management of PEG affected patients. Read More

Br J Ophthalmol 2016 Jan 16;100(1):94-7. Epub 2015 Sep 16.

Department of Ophthalmology, Caritas Medical Centre, Kowloon, Hong Kong.

Laser trabeculoplasty has an increasing important role in the management of glaucoma as more emphasis is placed on minimally invasive therapies. In recent years, the following laser trabeculoplasty technologies have been introduced: micropulse laser trabeculoplasty, titanium-sapphire laser trabeculoplasty and pattern scanning trabeculoplasty. These lasers help to reduce the intraocular pressure (IOP) and the burden of glaucoma medical therapy. Read More

Clin Exp Ophthalmol 2016 Jan-Feb;44(1):33-42. Epub 2015 Dec 7.

Department of Pathology, University of Western Ontario, London, Ontario, Canada.

Background: Matrix metalloproteinases (MMPs) are reported to contribute to the mechanism of argon laser trabeculoplasty, but it is unknown whether they are also secreted after selective laser trabeculoplasty (SLT). The aim of this study was to investigate whether human primary trabecular meshwork (HTM) cells secrete MMP-3 after stimulation by SLT. The relationship between SLT and the two principal forms of cell death, apoptosis and necrosis, was also examined. Read More

Acta Ophthalmol 2016 May 27;94(3):217-25. Epub 2015 Jun 27.

Wills Eye Hospital, Philadelphia, PA, USA.

Primary angle-closure glaucoma is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide. Angle closure is characterized by appositional approximation or contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly positioned or pushed lenses, and angle crowding. Read More

J Ophthalmol 2015 12;2015:476138. Epub 2015 May 12.

Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, Mail Stop F-731, Aurora, CO 80045, USA.

Purpose. To compare morphologic changes in human trabecular meshwork (TM) after selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT). Design. Read More

Clin Ophthalmol 2015 22;9:907-19. Epub 2015 May 22.

First and Third Departments of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Exfoliative glaucoma is the most common type of secondary open-angle glaucoma worldwide. It is characterized by high intraocular pressure (IOP) and worse 24-hour IOP characteristics. In order to minimize progression, treatment of exfoliative glaucoma has to provide a low long-term mean IOP and good 24-hour IOP control. Read More

Clin Ophthalmol 2015 11;9:833-41. Epub 2015 May 11.

Westmead Hospital, Westmead, NSW, Australia ; Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW, Australia ; Save Sight Institute, University of Sydney, Sydney, NSW, Australia.

Selective laser trabeculoplasty (SLT) has been used in the treatment of glaucoma for just over a decade. Here, we review the current literature in terms of suggested mechanism, efficacy, method of treatment, predictors of success, adverse events, repeatability, and cost of SLT. The exact mechanism by which SLT lowers intraocular pressure (IOP) remains unknown although circumstantial evidence has come in many forms in relation to structural alteration; oxidative stress and inflammatory responses; tight junction integrity; proliferative responses; and microbubble formation. Read More

J Ophthalmic Vis Res 2014 Oct-Dec;9(4):444-8

Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.

Purpose: To evaluate long term intraocular pressure (IOP) control after repeat selective laser trabeculoplasty (SLT).

Methods: This single center study retrospectively reviews the electronic medical records of patients with open angle glaucoma undergoing repeat SLT. Eyes with prior argon laser trabeculoplasty, or incisional surgery before or during the study period were excluded. Read More

J Glaucoma 2016 Mar;25(3):e157-61

*Department of Ophthalmology ‡Francis I. Proctor Foundation §Department of Epidemiology and Biostatistics, Division of Preventive Medicine and Public Health, University of California San Francisco ∥Department of Ophthalmology, San Francisco Veterans Affairs Medical Center, San Francisco, CA †Department of Ophthalmology, Oregon Health and Science University, Portland, OR.

Purpose: To compare intraocular pressure (IOP) reduction and complications of resident-performed argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT).

Patients And Methods: This was a retrospective, interventional, comparative case series performed at the San Francisco Veterans Affairs Hospital. The study included 77 patients each undergoing 1 resident-performed ALT procedure from April 2006 through November 2009, and 81 patients each undergoing 1 resident-performed SLT procedure from November 2009 through December 2011. Read More

Middle East Afr J Ophthalmol 2015 Jan-Mar;22(1):2-9

Department of Ophthalmology, Cairo University, Giza, Egypt.

Noninvasive glaucoma procedures (NIGPs) represent a new dawn in the management of glaucoma. They try to fill the gap between the shortcoming of invasive glaucoma surgeries and antiglaucoma medications. NIGPs were introduced as an adjunct or alternative treatments for glaucoma. Read More

Rom J Ophthalmol 2015 Jan-Mar;59(1):68-70

The paper presents a case of a pseudoexfoliative glaucoma previously treated with argon laser trabeculoplasty in a tertiary center, who was scheduled for canaloplasty in the Ophthalmology Department of the County Hospital Piatra Neamt, Romania. Although the status post laser trabeculoplasty is not among the best indications for canaloplasty, the article confirms the fact that this procedure can also be successfully performed in these cases. Read More

Clinicoecon Outcomes Res 2014 4;6:523-30. Epub 2014 Dec 4.

Department of Ophthalmology, University Hospital Ayr, South Ayrshire, UK ; Faculty of Medicine, University of Glasgow, Glasgow, UK.

Glaucoma is the second highest cause of blindness worldwide with an estimated half of the glaucoma population unaware of their disease. To date, intraocular pressure is the most important modifiable risk factor and lowering it has been proven to reduce progression of visual field loss associated with glaucoma. Different strategies are available to lower intraocular pressure and include medical, laser, or surgical treatment in the form of topical or systemic medications, argon or selective laser trabeculoplasty, and glaucoma drainage surgery such as trabeculectomy, deep sclerectomy, or other drainage devices. Read More

J Fr Ophtalmol 2014 Dec 14;37(10):812-7. Epub 2014 Nov 14.

Département d'ophtalmologie, hôpital Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.

Purpose: To determine long-term efficacy of selective Laser Trabeculoplasty (SLT) over 12 years in chronic open-angle glaucoma (OAG) patients.

Methods: In this retrospective study, all patients treated by SLT between 1997 and 1999 for OAG were included and followed up every 6 months. The procedure was performed with a Coherent Selecta 7000 Nd:YAG with 100 ± 10 non overlapping 400 μm spots over 360 degrees centered on the trabecular meshwork. Read More

Clin Exp Ophthalmol 2015 May-Jun;43(4):320-7. Epub 2014 Nov 4.

Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia.

Background: To investigate the effects of current intraocular pressure-lowering medications on the efficacy of selective laser trabeculoplasty.

Design: Retrospective chart review of records from an urban glaucoma clinic in Sydney, Australia.

Participants: Patients who received their first selective laser trabeculoplasty between 2002 and 2005 were studied (grouped from 0 to 3 according to the number of pre-selective laser trabeculoplasty medications, and followed for 5 years). Read More

Surv Ophthalmol 2015 Jan-Feb;60(1):36-50. Epub 2014 Jul 2.

Department of Ophthalmology, The University of Hong Kong, Hong Kong SAR, People's Republic of China.

Selective laser trabeculoplasty (SLT) is a relatively new type of laser used in treating open-angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and argon laser trabeculoplasty (ALT). We summarize available evidence for considering SLT as an alternative treatment in OAG through systematic review and meta-analysis. Among OAG patients who range from newly diagnosed to those on maximally tolerated medical therapy, SLT results in a 6. Read More

Ophthalmologe 2014 Oct;111(10):948-53

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Leipzig AöR, Liebigstr. 10-14, 04103, Leipzig, Deutschland.

Introduction: Argon laser trabeculoplasty (ALT) and pattern laser trabeculoplasty (PLT) are two laser surgery methods for treatment of open angle glaucoma and the effect in reducing intraocular pressure (IOP) of these methods was compared in a retrospective study.

Methods: The IOP, the best corrected visual acuity (BCVA) and the eye drop glaucoma medication used by patients who were treated by ALT or PLT in this clinic between January 2011 and December 2012 were compiled and evaluated.

Results: An ALT was carried out on 22 eyes from 22 patients (13 right and 9 left eyes in patients with an average age of 71. Read More

Curr Eye Res 2014 Sep 21;39(9):908-16. Epub 2014 Feb 21.

Department of Ophthalmology .

Purpose: Patterned laser trabeculoplasty (PLT) was introduced as it claimed to cause less thermal damage and provide more uniform coverage of the trabecular meshwork than argon laser trabeculoplasty (ALT). The objective of this study was to investigate morphologic changes in the trabecular meshwork after PLT or ALT in cats.

Materials And Methods: We performed ALT in the right eyes and PLT in the left eyes of 6 domestic cats. Read More

PLoS One 2013 19;8(12):e84270. Epub 2013 Dec 19.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.

Objective: To examine possible differences in clinical outcomes between selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT) in open-angle glaucoma at different times post-treatment.

Methods: Randomized controlled trials (RCTs) comparing SLT versus ALT were searched through August 2013. The main outcome measure was IOP, and secondary outcomes included the number of glaucoma medications, the success rate, and adverse events. Read More

Clin Exp Ophthalmol 2014 Sep-Oct;42(7):675-81. Epub 2014 Jan 27.

Ivey Eye Institute, St. Joseph's Hospital, London, Ontario, Canada.

Selective laser trabeculoplasty is a safe and effective treatment for glaucoma, with greater cost effectiveness than its pharmacological and surgical alternatives. Nevertheless, although the basic science literature on selective laser trabeculoplasty continues to grow, there remains uncertainty over the mechanism by which laser trabeculoplasty reduces intraocular pressure. To address this uncertainty, the evidence behind several potential biological and mechanical mechanisms of selective laser trabeculoplasty were reviewed. Read More

Eye (Lond) 2014 Mar 6;28(3):249-58. Epub 2013 Dec 6.

College of Medicine, Swansea University, Singleton Park, Swansea, UK.

Purpose: Systemic review to compare selective laser trabeculoplasty (SLT) to other glaucoma treatment options in terms of their intraocular pressure (IOP)-lowering effect.

Methods: Searches of the following databases were performed: PubMed, Cochrane Central Register of Controlled Trials, Ovid, EMBASE, metaRegister of Controlled Trials, and ClinicalTrials.gov. Read More

Am J Ophthalmol 2013 Nov 15;156(5):927-935.e2. Epub 2013 Aug 15.

Mayo Clinic, Department of Ophthalmology, Rochester, Minnesota.

Purpose: To determine outcomes of ab interno trabeculotomy for treatment of open-angle glaucoma (OAG).

Design: Retrospective interventional single-surgeon, single-center case series.

Methods: Data were collected from 246 patients undergoing ab interno trabeculotomy between September 1, 2006, and December 1, 2010, with 3 months' follow-up or longer. Read More

Am J Ophthalmol 2013 Nov 7;156(5):936-940.e2. Epub 2013 Aug 7.

Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To assess the effect of selective laser trabeculoplasty (SLT) following failed phacoemulsification cataract extraction combined with ab interno trabeculectomy (AIT) using the Trabectome (phaco-trabectome).

Design: Randomized, interventional case series.

Methods: Retrospectively, the medical records of patients who underwent SLT between March 2010 and July 2012 by 1 surgeon at a single center after a failed phaco-AIT were evaluated. Read More

J Glaucoma 2015 Jun-Jul;24(5):344-7

*Department of Ophthalmology, University of Western Ontario, London †Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON ‡Department of Ophthalmology, University of Alberta, Edmonton ∥Department of Ophthalmology, University of Calgary, Calgary, AB §Department of Ophthalmology, University of Montreal, Montreal, QC, Canada.

Purpose: To evaluate the efficacy of selective laser trabeculoplasty (SLT) versus argon laser trabeculoplasty (ALT) in lowering the intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension secondary to pseudoexfoliation.

Design: Multicentered randomized clinical trial.

Participants: A total of 76 eyes from 60 patients with pseudoexfoliation and uncontrolled IOP were recruited from 5 Canadian academic institutions. Read More