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J Curr Glaucoma Pract 2020 Sep-Dec;14(3):81-86

Department of Ophthalmology, McMaster University, Hamilton, Ontario, Canada.

Aim: To describe the current practice patterns and perceptions of Canadian ophthalmologists using laser trabeculoplasty (LTP).

Materials And Methods: A cross-sectional survey of 124 members of the Canadian Ophthalmological Society (COS) who perform LTP was conducted. Descriptive statistics and Chi-square comparative analyses were performed on anonymous self-reported survey data. Read More

Eye (Lond) 2021 Feb 9. Epub 2021 Feb 9.

Centre for Public Health, Queen's University, Belfast, UK.

To assess the comparative effectiveness and safety of different surgical and laser techniques in people with pseudoexfoliation glaucoma (PXFG). We conducted a systematic review including randomized controlled trials (RCT) that compared any pair of surgical or laser treatment versus other type of intervention in PXFG. RCT were identified by a highly sensitive search of electronic databases and two individuals independently assessed trial eligibility, abstracted data and assessed risk of bias. Read More

Acta Ophthalmol 2021 May 29;99(3):269-274. Epub 2020 Oct 29.

Department of Clinical Sciences, Ophthalmology, Umeå University, Umeå, Sweden.

Purpose: To evaluate the intraocular pressure (IOP)-lowering effect of laser trabeculoplasty (LTP) in eyes which IOP had been substantially reduced by intensive topical treatment for one week.

Methods: Patients with newly diagnosed open-angle glaucoma were randomized to treatment with three IOP-lowering substances. One week later, 360° argon or selective LTP was performed. Read More

Am J Ophthalmol 2020 Sep 1. Epub 2020 Sep 1.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:

Purpose: To comprehensively evaluate the effectiveness of different types of laser trabeculoplasty (LT) in the treatment of open-angle glaucoma.

Design: Systematic review and network meta-analysis.

Methods: Eligible randomized controlled trials (RCT) were identified by searching PubMed, EMBASE, Cochrane Library, SCOPUS, CNKI, and CBM for studies published between January 1, 2000 and April 20, 2020. Read More

Am J Ophthalmol Case Rep 2020 Sep 29;19:100835. Epub 2020 Jul 29.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe the results of selective laser trabeculoplasty (SLT) in eyes with angle recession glaucoma (ARG). To our knowledge, this is the first report of SLT being used as treatment modality for angle recession glaucoma. Argon laser trabeculoplasty (ALT) was used for ARG but showed a little therapeutic effect. Read More

J Glaucoma 2020 08;29(8):e91-e92

Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ.

Purpose: To provide the first report on argon laser peripheral iridoplasty (ALPI) to restore XEN-45 Gel stent patency after iris occlusion.

Methods: Case description, laser technique, and relevant clinical imaging.

Results: A 53-year-old African American male patient presented with progressive advanced stage primary open-angle glaucoma. Read More

Indian J Ophthalmol 2020 04;68(4):615-619

Department of Glaucoma, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India.

Purpose: To determine the safety and efficacy of mitomycin C (MMC) injection versus sponge during trabeculectomy.

Methods: It is a prospective analysis of patients who underwent trabeculectomy with MMC and followed up for 1 year, divided into two groups, namely, group 1- injection (n = 21), group 2-> sponge (n = 21). The same concentration of MMC was used for both groups. Read More

Ophthalmology 2020 02;127(2):e13

West Virginia University, Morgantown, West Virginia. Electronic address:

Ophthalmology 2019 11;126(11):e83

Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Curr Opin Ophthalmol 2019 Nov;30(6):484-490

Department of Ophthalmology, Stony Brook University, Stony Brook, New York, New York, USA.

Purpose Of Review: As humans spend a considerable portion of life in the horizontal position, it is vital to better understand the effect of sleep position on glaucoma.

Recent Findings: The mean positional increase from the supine position to the lateral decubitus position (LDP) in recent literature is less than 2 mmHg for each eye in its dependent position and less than 1 mmHg in the nondependent position. The right LDP is most commonly favored sleeping position. Read More

Vestn Oftalmol 2019 ;135(4):103-107

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Laser trabeculoplasty is one of the methods used to decrease intraocular pressure (IOP) as part of comprehensive glaucoma treatment. Argon laser trabeculoplasty (ALT) and diode laser trabeculoplasty (DLT) are two of the most widely used laser trabeculoplasty techniques. The mechanism of its hypotensive action is based on the effect that laser emission photocoagulate has on trabecular meshwork and subsequent outflow facilitation, but the difference in wavelength and emission energy determine the difference in direct laser action and the features of postoperative clinical appearance. Read More

J Glaucoma 2019 09;28(9):767-771

Department of Ophthalmology, Saint Joseph Hospital.

Precis: Argon laser peripheral iridoplasty (ALPI) was performed on 48 eyes with plateau iris syndrome (PIS). Indentation gonioscopy was used to monitor the opening of the iridocorneal angle. Mean intraocular pressure (IOP) at 5 years decreased from 15. Read More

Klin Monbl Augenheilkd 2019 May 16;236(5):647-652. Epub 2019 May 16.

Augenklinik, Universitätsmedizin Mainz.

Many clinical studies have demonstrated the benefit of topical anti-inflammatory medication before and after glaucoma surgery, especially for trabeculectomy, and that they improve the long term outcome. Pre- and postoperative topical steroids improve the outcome of trabeculectomy, but duration and intensity of treatment should be adapted individually. Systemic steroid or oral immunomodulation have significant impact on the outcome in uveitic glaucoma, but not in other glaucoma subtypes. Read More

Acta Ophthalmol 2020 Feb 15;98(1):58-64. Epub 2019 May 15.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Purpose: To explore the efficacy of selective laser trabeculoplasty (SLT) within eyes with exfoliative glaucoma and history of prior argon laser trabeculoplasty (ALT).

Methods: A single-centre trial consisting of 47 patients (47 eyes) with uncontrolled exfoliative glaucoma. The main outcome measure was intraocular pressure (IOP) reduction 3 and 9 months after SLT. Read More

Eye (Lond) 2019 01 22;33(1):110-119. Epub 2018 Nov 22.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

Acute primary angle closure requires emergency management that involves a rapid lowering of the intraocular pressure and resolution of relative pupil block - the most common mechanism of angle closure. Emergency strategies for lowering intraocular pressure include medical treatment and argon laser peripheral iridoplasty. Anterior chamber paracentesis and diode laser transcleral cyclophotocoagulation may be considered in special situations. Read More

Ophthalmology 2019 02 29;126(2):223-232. Epub 2018 Sep 29.

Department of Ophthalmology, Western University, Ontario, Canada. Electronic address:

Purpose: The effectiveness of selective laser trabeculoplasty (SLT) was compared with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically uncontrolled open-angle glaucoma who have previously received 360° SLT.

Design: An active equivalence parallel armed randomized control trial.

Participants: Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syndrome were enrolled into the study from 7 different sites across Canada. Read More

Clin Ophthalmol 2018 6;12:1359-1365. Epub 2018 Aug 6.

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan,

Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan.

Study Design: A single-center, retrospective case series.

Methods: We retrospectively reviewed all medical records of bullous keratopathy (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Read More

Acta Ophthalmol 2018 Aug 14;96(5):e582-e591. Epub 2018 Apr 14.

Department of Ophthalmology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Purpose: To report on the efficacy and safety of CO laser-assisted sclerectomy surgery (CLASS) compared with trabeculectomy in primary open-angle glaucoma and exfoliative glaucoma.

Methods: One hundred and thirty-one patients underwent CLASS (66 patients) or trabeculectomy (65 patients) and were followed up for 12 months. 'Complete success' was defined as intraocular pressure (IOP) between 10 and 18 mmHg and reduced by at least 30% from the baseline without medications, while 'qualified success' was compliant with the above criteria with or without the medications. Read More

Adv Ther 2018 05 11;35(5):619-630. Epub 2018 Apr 11.

Department of Ophthalmology, Hospital Universitario "Principe de Asturias," Universidad de Alcalá, Alcalá de Henares, Spain.

In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. Read More

Klin Monbl Augenheilkd 2019 Oct 11;236(10):1192-1200. Epub 2018 Apr 11.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg.

Background: Laser trabeculoplasty (LTP) is a well established treatment modality in the management of chronic open angle glaucoma. Nonetheless there is much variation in practice.

Methods: A literature search in the PubMed database was conducted and the most important evidence-based results were summarised. Read More

Ghana Med J 2017 Dec;51(4):175-180

Department of Ophthalmology, University of Ibadan College of Medicine, Ibadan, Oyo, Nigeria.

Aim: To report the safety and efficacy of Argon Laser Trabeculoplasty (ALT) in reducing intraocular pressure (IOP).

Settings And Design: This was a retrospective study performed on 25 eyes of 25 patients.

Methods And Materials: Consecutive patients who met the inclusion criteria for ALT were recruited from the ophthalmic clinic of the University College Hospital Ibadan, Nigeria and followed up for a minimum period of six months. Read More

Rom J Ophthalmol 2017 Apr-Jun;61(2):117-122

"Gr. T. Popa" University of Medicine and Pharmacy, Iași, Romania.

We present the therapeutic options and functional results in patients with plateau iris (syndrome or configuration) in consecutive case series. Our study included newly diagnosed patients with acute angle closure by "plateau iris" (configuration or syndrome), between June 2016 and April 2017. Series of 8 consecutive patients met the inclusion criteria, all being females. Read More

Can J Ophthalmol 2018 02 27;53(1):70-75. Epub 2017 Sep 27.

Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, N.S.

Objective: Laser trabeculoplasty effectively reduces intraocular pressure (IOP) in primary open angle glaucoma, with argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) showing equivalent outcomes. However, it is unclear which laser modality is more effective in pseudoexfoliation (PXE) glaucoma. This study aims to compare the effectiveness of ALT and SLT in PXE glaucoma. Read More

J Glaucoma 2018 07;27 Suppl 1:S91-S94

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB, Canada.

Argon laser trabeculoplasty as well as selective laser trabeculoplasty can be used in patients with exfoliation syndrome with similar safety and efficacy. However, treatment effect may abruptly reverse and patients need to be followed regularly to monitor intraocular pressure control. Newer laser treatment modalities including micropulse laser trabeculoplasty, titanium sapphire laser trabeculoplasty and pattern scanning trabeculoplasty show promising results but need to be studied in exfoliation patients. Read More

Eye (Lond) 2018 05 5;32(5):863-876. Epub 2018 Jan 5.

Department of Glaucoma, Moorfields Eye Hospital, London, UK.

Over the past two decades, selective laser trabeculoplasty (SLT) has increasingly become an established laser treatment used to lower intraocular pressure in open-angle glaucoma and ocular hypertensive patients. In this review we trace the origins of SLT from previous argon laser trabeculoplasty and review the current role it has in clinical practice. We outline future directions of SLT research and introduce emerging technologies that are further developing this intervention in the treatment paradigm of glaucoma. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Jan 17;256(1):181-186. Epub 2017 Nov 17.

Clinica Oculistica Università di Genova DiNOGMI - Ospedale Policlinico San Martino, Viale Benedetto XV, 5, 16136, Genoa, Italy.

Purpose: Our purpose was to evaluate the clinical safety and efficacy of CO laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG).

Methods: This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. Read More

Eur J Ophthalmol 2018 Jan;28(1):119-122

1 Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA.

Purpose: To provide a clinical description of the long-term outcome of a Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.

Methods: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. Read More

J Cataract Refract Surg 2017 07;43(7):886-891

From the Dipartimento di Scienze Chirurgiche (Fea), Clinica Oculistica di Torino, Torino, Italy; the Department of Ophthalmology (Rekas), Military Institute of Medicine, Warsaw, Poland; the Manchester Royal Eye Hospital (Au), Central Manchester Foundation Trust, Manchester, United Kingdom.

Purpose: To evaluate the efficacy and the safety of a new Schlemm canal scaffold microstent (Hydrus) combined with cataract surgery in routine clinical practice.

Settings: Clinics in Italy, Poland, and the United Kingdom.

Design: Retrospective case series. Read More

Klin Monbl Augenheilkd 2017 Nov 28;234(11):1362-1371. Epub 2017 Jun 28.

Augenheilkunde, Tagesklinik Ambimed, Basel, Schweiz.

Worldwide, in recent years, selective laser trabeculoplasty (SLT) has developed into a very successful therapy for glaucoma. The article provides a review of the literature from PubMed and clinical experience. SLT is equally efficacious to argon laser trabeculoplasty (ALT) and to a first-line glaucoma medication. Read More

Cochrane Database Syst Rev 2017 02 23;2:CD010746. Epub 2017 Feb 23.

Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, Michigan, USA, 48105.

Background: Glaucoma is the international leading cause of irreversible blindness. Intraocular pressure (IOP) is the only currently known modifiable risk factor; it can be reduced by medications, incisional surgery, or laser trabeculoplasty (LTP). LTP reduces IOP by 25% to 30% from baseline, but early acute IOP elevation after LTP is a common adverse effect. Read More