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What Interpersonal Problems Are Related to Different Therapeutic Techniques Early in Treatment?

Clin Psychol Psychother 2019 Apr 24. Epub 2019 Apr 24.

Derner School of Psychology, Adelphi University.

The current study seeks to explore the relationship between patient-reported interpersonal problems and therapist interventions in early psychodynamic psychotherapy for 71 outpatients. Pre-treatment ratings on the Inventory of Interpersonal Problems (IIP-C; Horowitz, Alden, Wiggins, & Pincus, 2000) total and subscale scores were examined in relation to early treatment process. Independent clinicians reliably rated therapist use of Psychodynamic-Interpersonal (PI) and Cognitive-Behavioral (CB) interventions using the CPPS (Hilsenroth, Blagys, Ackerman, Bonge, & Blais, 2005) over two early treatment sessions (3 & 9 ). Read More

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http://dx.doi.org/10.1002/cpp.2370DOI Listing

A Case of Chronic and Relapsing Paget Disease of the Vulva.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatovenereology, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.

Extramammary Paget disease is a rare neoplastic condition that more commonly affects postmenopausal Caucasian women. Although the vulvar area is the most frequently affected location, it corresponds solely to 1 to 2% of all vulvar malignancies. A 72-year-old female patient was observed in our outpatient clinic with a 2-year history of an erythematous and pruritic plaque on the vulva. Read More

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http://dx.doi.org/10.1055/s-0039-1687861DOI Listing
April 2019
1 Read

Objective assessment of blinking and facial expressions in Parkinson's disease using vertical electrooculogram and facial surface electromyography.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Istituto di BioRobotica, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, Pontedera, 56025, ITALY.

Objective: Hypomimia is a common and early symptom of Parkinson's disease (PD), which reduces the ability of PD patients in manifesting emotions. Currently, it is visually evaluated by the neurologist during neurological examinations for PD diagnosis as described in task 3.2 of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Read More

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http://dx.doi.org/10.1088/1361-6579/ab1c05DOI Listing

Associations between self-generated strategy use and MET-Home performance in adults with stroke.

Neuropsychol Rehabil 2019 Apr 24:1-15. Epub 2019 Apr 24.

e School of Occupational Therapy , Texas Woman's University , Dallas , TX , USA.

Self-generated strategy use has substantial potential for improving community living outcomes in adults with impaired executive function after stroke. However, little is known about how self-generated strategies support task performance in people with post-stroke executive function impairments living in the community. We explored strategy use among home-dwelling persons with stroke and neurologically-healthy control participants during the Multiple Errands Test-Home Version (MET-Home), a context-specific assessment with evidence of ecological validity designed to examine how post-stroke executive dysfunction manifests during task performance in the home environment. Read More

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http://dx.doi.org/10.1080/09602011.2019.1601112DOI Listing

Layer-by-Layer Assembly of Three-Dimensional Optical Functional Nanostructures.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Nanotransfer printing (nTP) technology can generate highly functional three-dimensional (3D) nanostructures in a low-cost and high-throughput fashion. Nevertheless, the fabrication yield and quality of the transferred nanostructures are often limited by the merging of the surface patterns of replica stamps during transfer printing. Here, an nTP technology was developed to fabricate large-area and crack-free 3D multilayer nanostructures. Read More

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http://dx.doi.org/10.1021/acsnano.9b00549DOI Listing

A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value.

FEBS J 2019 Apr 24. Epub 2019 Apr 24.

Biochemistry, Biochemical Analysis& Matrix Pathobiochemistry Research Group, Department of Chemistry, University of Patras, 26504, Patras, Greece.

Hyaluronan is a unique non-sulfated glycosaminoglycan that contributes to breast cancer cells growth and functional properties, including cell migration, invasion, adhesion, as well as tumor-associated angiogenesis in different stages of breast cancer progression and especially metastasis. Latest data show that the levels of hyaluronan and/or low molecular mass hyaluronan in blood serum and plasma of breast cancer patients may be a useful biomarker for breast cancer prognosis, differential diagnosis and patients' treatment monitoring. Therefore, the qualitative and quantitative determination of hyaluronan in biological samples is an emerging area of research. Read More

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http://dx.doi.org/10.1111/febs.14860DOI Listing
April 2019
1 Read

The diagnostic ability of high-fluorescent cells combined with carcinoembryonic antigen for malignant pleural effusion.

Int J Lab Hematol 2019 Apr 24. Epub 2019 Apr 24.

Department of Clinical Laboratory, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Introduction: High-fluorescent cells (HFCs) that are detected with an automated hematology analyzer may be useful for the detection of tumor cells; however, the diagnostic ability of HFCs for differentiating malignant pleural effusion is limited. The aim of this study was to investigate the diagnostic value of the combined detection of HFCs with the tumor marker carcinoembryonic antigen (CEA) for the identification of malignant hydrothorax.

Methods: A total of 115 pleural effusions were collected. Read More

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http://dx.doi.org/10.1111/ijlh.13034DOI Listing

Infiltrating CD4+ T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing, China.

Background: Chemotherapy with Docetaxel (Doc) is efficient in a subset of prostate cancer (PCa) cases; however, most patients ultimately develop resistance to Docetaxel. The tumor immune microenvironment and secreted cytokines play a substantial role in development of resistance to chemotherapy. Our previous study has demonstrated that CD4+ T cells in prostate tumor microenvironment contribute to PCa progression; meanwhile, we found increased CD4+ T-cell infiltration in tumor area after Doc treatment; however, their effects on PCa chemosensitivity remain unclear. Read More

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http://dx.doi.org/10.1002/pros.23810DOI Listing

Plant protection product dose rate estimation in apple orchards using a fuzzy logic system.

PLoS One 2019 24;14(4):e0214315. Epub 2019 Apr 24.

University of Maribor, Faculty of Mechanical Engineering, Laboratory for Structure Evaluation, Maribor, Slovenia.

In the process of applying a plant protection product mixed with water (spray mixture) at the prescribed concentration with conventional sprayers for chemical protection of tree canopies in an orchard, standard models are used to express the dose rate of the plant protection product. Characteristic properties of the tree canopy in an orchard are not taken into consideration. Such models result in fixed quantities of spray mixture being sprayed through individual nozzles into a tree canopy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214315PLOS

Stakeholders' perceptions of protected area management following a nationwide community-based conservation reform.

PLoS One 2019 24;14(4):e0215437. Epub 2019 Apr 24.

Department of Arctic and Marine Biology, UIT-The Arctic University of Norway, Tromsø, Norway.

People's perceptions can point to reasons for conservation support or lack thereof. In this study, we surveyed the perceptions of conservation among local stakeholders who participated in protected area (PA) management following a reform towards community-based conservation in Norway. We analyzed the link between perceptions of threats to conservation values, prioritized management actions and trust in PA governance, and assessed how these perceptions aligned with the stakeholders' preferred overarching conservation approach and their support for PAs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215437PLOS

Infant crying and the calming response: Parental versus mechanical soothing using swaddling, sound, and movement.

PLoS One 2019 24;14(4):e0214548. Epub 2019 Apr 24.

Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands.

Background: Frequent infant crying is associated with parental exhaustion, depression, or even infant hospitalization and shaken baby syndrome. Effective prompt soothing methods are lacking for infants under 6 months. We examined whether swaddling, sound, and movement evoked an immediate calming response (CR) when parents soothed their infants and using a smart crib, and whether infant age affected the CR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214548PLOS

Mobility and social identity in the Mid Upper Paleolithic: New personal ornaments from Poiana Cireșului (Piatra Neamț, Romania).

PLoS One 2019 24;14(4):e0214932. Epub 2019 Apr 24.

"Princely Court" National Museum Târgovişte, Museum of Human Evolution and Technology in Paleolithic, Târgovişte, Dâmboviţa County, Romania.

Most of the Paleolithic art and ornaments discovered in Romania come from the site of Poiana Cireșului. Four Paleolithic layers have been studied at this site-the oldest one belongs to the Early Gravettian period between 30 ka and 31 ka BP. The ornaments discovered in this layer include perforated shells from three species of mollusks: freshwater Lithoglyphus naticoide and Lithoglyphus apertus as well as Homalopoma sanguineum (an exclusively Mediterranean species). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214932PLOS

Insights into the timing, intensity and natural setting of Neanderthal occupation from the geoarchaeological study of combustion structures: A micromorphological and biomarker investigation of El Salt, unit Xb, Alcoy, Spain.

PLoS One 2019 24;14(4):e0214955. Epub 2019 Apr 24.

Instituto Universitario de Biorgánica Antonio González, Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain.

Middle Paleolithic lithic and faunal assemblages throughout Eurasia reflect short-term Neanderthal occupations, which suggest high group mobility. However, the timing of these short-term occupations, a key factor to assess group mobility and territorial range, remains unresolved. Anthropogenic combustion structures are prominent in the Middle Paleolithic record and conceal information on the timing and intensity and natural setting of their associated human occupations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214955PLOS

Diaphragm sniff ultrasound: Normal values, relationship with sniff nasal pressure and accuracy for predicting respiratory involvement in patients with neuromuscular disorders.

PLoS One 2019 24;14(4):e0214288. Epub 2019 Apr 24.

Service de Physiologie-Explorations fonctionnelles, CHU Raymond Poincaré, APHP, Université de Versailles saint Quentin en Yvelines, Garches, France.

Background: In patients with neuromuscular disorders, assessment of respiratory function relies on forced vital capacity (FVC) measurements. Providing complementary respiratory outcomes may be useful for clinical trials. Diaphragm sniff ultrasound (US) is a noninvasive technique that can assess diaphragm function that may be affected in patients with neuromuscular disorders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214288PLOS

Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data.

PLoS One 2019 24;14(4):e0202063. Epub 2019 Apr 24.

VCU Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.

Genome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the disorder and provide incomplete mechanistic understanding of this complex trait. Integrating brain ethanol-responsive gene expression networks from model organisms with human genetic data on alcohol dependence could aid in identifying dependence-associated genes and functional networks in which they are involved. This study used a modification of the Edge-Weighted Dense Module Searching for genome-wide association studies (EW-dmGWAS) approach to co-analyze whole-genome gene expression data from ethanol-exposed mouse brain tissue, human protein-protein interaction databases and alcohol dependence-related genome-wide association studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202063PLOS
April 2019
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Impact of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae.

PLoS One 2019 24;14(4):e0200978. Epub 2019 Apr 24.

College of Marine Sciences, South China Agricultural University, Guangzhou, China.

1,3-Propanediol (1,3-PDO) is an important compound that is mainly used in industry for polymer production. Fermentation of 1,3-PDO from glycerol by Klebsiella pneumoniae is accompanied by formation of 2,3-butanediol (2,3-BDO) as one of the main byproduct. The first step in the formation of 2,3-BDO from pyruvate is catalyzed by acetolactate synthase (ALS), an enzyme that competes with 1,3-PDO oxidoreductase for the cofactor NADH. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200978PLOS

Defining a Core Data Set for Registry of Esophageal Atresia in the Northwest of Iran.

J Registry Manag 2018 ;45(3):132-135

Defining the core data set is the main step for establishing a registry system. The aim of this study was to define the core data set for the registry of esophageal atresia in the northwest of Iran.

Methods: First, the preliminary list of data elements was extracted from the related registries of other countries, as well as from the literature. Read More

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January 2018

Validation of the Spanish Version of the Beginning Breastfeeding Survey-Cumulative: A Follow-up Study.

J Hum Lact 2019 Apr 24:890334419840003. Epub 2019 Apr 24.

2 Department of Nursing, University of Alicante, Alicante, Spain.

Background: The Beginning Breastfeeding Survey-Cumulative (BBSC) is an instrument that assesses the overall maternal perception of breastfeeding effectiveness during the early postpartum period.

Research Aims: The aims of this study were to adapt and validate a Spanish version of the BBSC and provide new evidence regarding its validity.

Methods: A standard forward and back-translation process was used to obtain the Spanish version of the questionnaire (BBSC-E). Read More

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http://dx.doi.org/10.1177/0890334419840003DOI Listing

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.

FASEB J 2019 Apr 24:fj201802711R. Epub 2019 Apr 24.

Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Osteoporosis is a major health problem, making bones fragile and susceptible to fracture. Previous works showed that mechanical loading stimulated bone formation and accelerated fracture healing. Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis. Read More

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http://dx.doi.org/10.1096/fj.201802711RDOI Listing

Magnetite Coated Boron Nitride Nanosheets for the Removal of Arsenic (V) from Water.

ACS Appl Mater Interfaces 2019 Apr 24. Epub 2019 Apr 24.

It is widely known that the existence of arsenic (As) in water negatively impacts the humans and the environment. We report the synthesis, characterization and application of boron nitride nanosheets (BNNSs) and Fe3O4 functionalized BNNS (BNNS-Fe3O4) nanocomposite for removal of As(V) ions from aqueous systems. The morphology, surface properties and compositions of synthesized nanomaterials were examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), surface area analysis, zero-point charge and magnetic moment determination. Read More

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http://dx.doi.org/10.1021/acsami.8b22401DOI Listing

Selectively Metalized 2D Materials for Simple Logic Devices.

ACS Appl Mater Interfaces 2019 Apr 24. Epub 2019 Apr 24.

We herein demonstrate, for the first time, transparent, flexible, and large-area monolithic MoS2 transistors and logic gates. Each single transistor consists of only two components: a monolithic chemical vapor deposition (CVD)-grown MoS2 layer and an ion-gel gate dielectric. Additional electrode materials are not required. Read More

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http://dx.doi.org/10.1021/acsami.9b03078DOI Listing

Silver Nanoparticle-doped 3D Porous Carbon Nanofibers as Separator Coating for Stable Lithium Metal Anodes.

ACS Appl Mater Interfaces 2019 Apr 24. Epub 2019 Apr 24.

The ever-increasing demand for electric devices and vehicles prompts the fast development of energy storage systems. Lithium metal is thought to be the most promising electrode for high performance batteries. However, the growth of lithium dendrites impedes the industrial production of lithium metal batteries. Read More

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http://dx.doi.org/10.1021/acsami.9b04122DOI Listing

Pharmacological modulation of the spatiotemporal disposition of micromotions in the intact resting urinary bladder of the rabbit; their pattern is under both myogenic and autonomic control.

BJU Int 2019 Apr 24. Epub 2019 Apr 24.

Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.

Objectives: To explore and characterize the disposition and dynamics of micromotions in the wall of the intact resting teradotoxinized urinary bladder of the rabbit before and after the administration of adrenergic and cholinergic pharmaceutical agents.

Methods: Spatiotemporal maps and related intravesical pressure were used to analyse propagating patches of contractions (PPCs) and their component individual myogenic contractions [propagating individual contractions (PICs)] in the wall of the tetradotoxinized urinary bladder.

Results: The bladder wall exhibited two contractile states that were of similar frequencies to those of the two types of electrophysiological discharge described in previous studies; the first, in which cyclic PPCs predominated, the second in which small irregular PICs predominated. Read More

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http://dx.doi.org/10.1111/bju.14715DOI Listing

Zebrafish fin regeneration involves transient serotonin synthesis.

Wound Repair Regen 2019 Apr 24. Epub 2019 Apr 24.

Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.

The zebrafish is a vertebrate organism capable of regenerating many of its organs. Notably, it can undergo epimorphic regeneration of its fins after amputation. This process occurs through the formation of a wound epithelium and the dedifferentiation of mesenchymal and bone-forming cells, which form a proliferative blastema. Read More

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http://dx.doi.org/10.1111/wrr.12719DOI Listing

The development of inflammatory arthritis and enthesitis in patients on dupilumab: a case series.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

St. John's Institute of Dermatology, Guy's and St, Thomas' Hospital NHS Trust, Great Maze Pond, London, SE1 9RT.

Dupilumab (Dupixent , Sanofi), a fully human monoclonal antibody that blocks interleukin (IL)-4 and IL-13 signaling, is the first biologic approved in the UK for adult patients with moderate-to-severe atopic dermatitis (AD). In phase III studies, dupilumab was an effective treatment with 44-51% of patients achieving at least 75% improvement in Eczema Area and Severity Index (EASI). To date, dupilumab has been well tolerated; common adverse reactions reported from phase III data include injection-site reactions (8-19%), allergic conjunctivitis (3-19%) and oral herpes (2-5%). Read More

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http://dx.doi.org/10.1111/bjd.18031DOI Listing

Sustained Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Severe Chronic Plaque Psoriasis from a Randomised, Double-Blind, Phase 3 Study.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Venerology and Allergy, Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Adalimumab (Humira , AbbVie Inc, USA) is EMA approved for children ages ≥4 years with severe plaque-psoriasis.

Objectives: Evaluate long-term efficacy and safety of adalimumab in children with severe plaque psoriasis.

Methods: Results are from the 52-week long-term extension (LTE) of the randomized, double-blind, double-dummy, phase-3 trial, in children with severe plaque psoriasis (results from prior periods are published). Read More

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http://dx.doi.org/10.1111/bjd.18029DOI Listing

A Multi-Institutional International Analysis of Textbook Outcomes Among Patients Undergoing Curative-Intent Resection of Intrahepatic Cholangiocarcinoma.

JAMA Surg 2019 Apr 24:e190571. Epub 2019 Apr 24.

The Ohio State University Wexner Medical Center, Columbus.

Importance: Composite measures may be superior to individual measures for the analysis of hospital performance and quality of surgical care.

Objective: To determine the incidence of a so-called textbook outcome, a composite measure of the quality of surgical care, among patients undergoing curative-intent resection of intrahepatic cholangiocarcinoma.

Design, Setting, And Participants: This cohort study involved an analysis of a multinational, multi-institutional cohort of patient from 15 major hepatobiliary centers in North America, Europe, Australia, and Asia who underwent curative-intent resection of intrahepatic cholangiocarcinoma between 1993 and 2015. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0571DOI Listing
April 2019
1 Read

Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Universite de Lorraine, INSERM Unite 1116, Vandoeuvre les Nancy, France.

Importance: Whether anticoagulation benefits patients with heart failure (HF) in sinus rhythm is uncertain. The COMMANDER HF randomized clinical trial evaluated the effects of adding low-dose rivaroxaban to antiplatelet therapy in patients with recent worsening of chronic HF with reduced ejection fraction, coronary artery disease (CAD), and sinus rhythm. Although the primary end point of all-cause mortality, myocardial infarction, or stroke did not differ between rivaroxaban and placebo, there were numerical advantages favoring rivaroxaban for myocardial infarction and stroke. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.1049DOI Listing

Regression models for the erector spinae muscle (ESM) cross-sectional area (CSA): Asymptomatic populations.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Associate Professor, Department of Industrial and Systems Engineering, Auburn University, Auburn, AL 36849, USA.

Understanding low back morphology is critical to understanding spinal loading and the underlying injury mechanisms, which helps to characterize risk and, therefore, minimize low back pain injuries. Individualized erector spinae muscle (ESM) cross-sectional area (CSA) allows biomechanics practitioners to calculate individualized force-generating capacities and spinal loadings for given tasks. The objective is to perform morphological analyses and then provide regression models to estimate the ESM CSA of an individual with his/her subject characteristics. Read More

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http://dx.doi.org/10.1115/1.4043558DOI Listing

Personalized Design of Functional Gradient Bone Tissue Engineering Scaffold.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing 210016, Jiangsu Province, People's Republic of China.

The porous structure of the natural bone not only has the characteristics of lightweight and high strength, but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Read More

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http://dx.doi.org/10.1115/1.4043559DOI Listing

Detecting Developmental Delay and Autism Through Machine Learning Models Using Home Videos of Bangladeshi Children: Development and Validation Study.

J Med Internet Res 2019 Apr 24;21(4):e13822. Epub 2019 Apr 24.

Division of Systems Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, United States.

Background: Autism spectrum disorder (ASD) is currently diagnosed using qualitative methods that measure between 20-100 behaviors, can span multiple appointments with trained clinicians, and take several hours to complete. In our previous work, we demonstrated the efficacy of machine learning classifiers to accelerate the process by collecting home videos of US-based children, identifying a reduced subset of behavioral features that are scored by untrained raters using a machine learning classifier to determine children's "risk scores" for autism. We achieved an accuracy of 92% (95% CI 88%-97%) on US videos using a classifier built on five features. Read More

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http://dx.doi.org/10.2196/13822DOI Listing

Serum C-reactive protein relationship in high- versus low-virulence pathogens in the diagnosis of periprosthetic joint infection.

J Med Microbiol 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstrasse 2, 22767 Hamburg, Germany.

Little is known about the relationship between the virulence of pathogens in periprosthetic joint infection (PJI) and C-reactive protein (CRP) levels. In this context, we assessed the performance of CRP for PJI. We collected the following data from 987 cases of total joint revision due to PJI and 386 cases of aseptic revision: age, gender, comorbidities, values for serum CRP, leukocytes, microbiology for preoperatively taken aspirations and at least 2 intraoperative biopsies, and presence or absence of a draining sinus. Read More

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http://dx.doi.org/10.1099/jmm.0.000958DOI Listing

Neuroprotective and long term potentiation improving effects of vitamin E in juvenile hypothyroid rats.

Int J Vitam Nutr Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

8 Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Protective effects of vitamin E (Vit E) on long term potentiation (LTP) impairment, neuronal apoptosis and increase of nitric oxide (NO) metabolites in the hippocampus of juvenile rats were examined. The rats were grouped (n=13) as: (1) control; (2) hypothyroid (Hypo) and (3) Hypo-Vit E. Propylthiouracil (PTU) was given in drinking water (0. Read More

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http://dx.doi.org/10.1024/0300-9831/a000533DOI Listing

The Evolution of Hypnosis in the Profession of Nursing: We've Come a Long Way, Baby, and Still Have a Long Way to Go.

Authors:
Linda Thomson

Am J Clin Hypn 2019 Apr;61(4):370-393

a Springfield Medical Care Systems , Springfield, Vermont , USA.

Registered nurses (RNs) are the largest, most diverse, and most respected of all healthcare professions in the United States, numbering over 3.5 million (Gallup poll, 2017). Nurses have evolved from being the handmaidens of physicians and bedpan handlers to highly trained and educated clinicians who have assumed an important, integral, and indispensable role in the healthcare system. Read More

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http://dx.doi.org/10.1080/00029157.2018.1500879DOI Listing
April 2019
2 Reads

A practical guide to test blueprinting.

Med Teach 2019 Apr 24:1-8. Epub 2019 Apr 24.

b Mayo Clinic College of Medicine and Science , Rochester , MN , USA.

A test blueprint describes the key elements of a test, including the content to be covered, the amount of emphasis allocated to each content area, and other important features. This article offers practical guidelines for developing test blueprints. We first discuss the role of learning outcomes and behavioral objectives in test blueprinting, and then describe a four-stage process for creating test blueprints. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1595556DOI Listing

Quantification of 1D, a novel derivative of curcumin with potential antitumor activity, in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study in rats.

Pharm Biol 2019 Dec;57(1):287-294

a Department of Pharmacy , the Affiliated Hospital of Qingdao University , Qingdao , PR China.

Context: 1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines.

Objective: To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 D in rat plasma.

Materials And Methods: An aliquot of 50 μL plasma sample was processed by protein precipitation with methanol. Read More

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http://dx.doi.org/10.1080/13880209.2019.1603243DOI Listing
December 2019

Auditory system dysfunction in Brazilian gasoline station workers.

Int J Audiol 2019 Apr 24:1-13. Epub 2019 Apr 24.

d Department of Communication Sciences and Disorders , University of Cincinnati , Cincinnati , OH , USA.

Objective: To examine the auditory system of Brazilian gasoline station workers using an extensive audiological test battery.

Design: This was a cross-sectional study. The audiological evaluation included a questionnaire, pure-tone audiometry, acoustic immittance tests, transient-evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR) and P300 auditory-evoked potentials. Read More

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http://dx.doi.org/10.1080/14992027.2019.1597286DOI Listing

Does choice of antiretroviral drugs matter for inflammation?

Expert Rev Clin Pharmacol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a HIV Infection Unit, Infectious Diseases Department , Hospital de la Santa Creu i Sant Pau Institut de Recerca del Hospital de la Santa Creu i Sant Pau , Barcelona , Spain.

Introduction: The massive implementation of combination antiretroviral therapy (cART) has forever changed the landscape of HIV infection. This unprecedented success has turned HIV infection into a manageable chronic disease. The increased survival of people living with HIV is, however, shadowed by a high burden of aging-related comorbidities. Read More

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http://dx.doi.org/10.1080/17512433.2019.1605902DOI Listing

Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: A randomized pilot study.

J Dermatolog Treat 2019 Apr 24:1-16. Epub 2019 Apr 24.

a Department of Zhoupu Hospital , Pudong New Area , Shanghai , 201318 , China.

Objective: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea.

Methods: A total of 130 (randomized 1:1) were externally administered either artemether emulsion (1%) or metronidazole emulsion (3%) twice daily for 4 weeks with an open-label 8-week follow-up. The primary endpoints included the proportion of patients who achieved clinical effective responses, as well as erythema and papule and pustule score at week 4. Read More

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http://dx.doi.org/10.1080/09546634.2019.1610549DOI Listing

Fruit and Vegetable Intake is Inversely Associated with Cancer Risk in Mexican-Americans.

Nutr Cancer 2019 Apr 24:1-9. Epub 2019 Apr 24.

b Department of Epidemiology , University of Texas Health Science Center-Houston, School of Public Health , Brownsville , Texas , USA.

Objective: There is inconsistent evidence and limited data in the Hispanic population concerning fruit and vegetable intake and cancer risk. This study explored the effect of fruit and vegetable intake on cancer risk in Mexican-Americans.

Methods: Participants in this cross-sectional study were drawn from the Cameron County Hispanic Cohort. Read More

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https://www.tandfonline.com/doi/full/10.1080/01635581.2019.1
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http://dx.doi.org/10.1080/01635581.2019.1603315DOI Listing
April 2019
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Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest.

Biomarkers 2019 Apr 24:1-24. Epub 2019 Apr 24.

a Department of Cardiology , Copenhagen University Hospital , Rigshospitalet , Copenhagen , Denmark.

Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome.

Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 hours after OHCA. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1609580DOI Listing

Validity of the CES-D for depression screening in military service members with a history of mild traumatic brain injury.

Brain Inj 2019 Apr 24:1-9. Epub 2019 Apr 24.

b Defense and Veterans Brain Injury Center (DVBIC) San Antonio VA Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System , San Antonio , Texas , USA.

Primary Objective: To advance knowledge about the value of the Center for Epidemiologic Studies - Depression scale (CES-D) for depression screening in military service members with a history of mild traumatic brain injury (mTBI).

Research Design: Retrospective data from 336 military service members with a history of mTBI were extracted from a TBI Repository at a large military medical center. Participants included in this study screened positive for mTBI in a primary care clinic or soldier readiness processing center and were enrolled in the TBI repository from November 6, 2014 to May 31, 2017. Read More

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http://dx.doi.org/10.1080/02699052.2019.1610191DOI Listing

Pharmacological Chaperones for the Treatment of α-Mannosidosis.

J Med Chem 2019 Apr 24. Epub 2019 Apr 24.

α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation in the lysosome, leading to severe pathology. Many of the AM causative mutations compromise enzyme folding and could be rescue with purpose-designed pharmacological chaperones (PCs). We found that PCs combining a LAMAN glycone-binding motif based on the 5N,6O-oxomethylidenemannonojirimycin (OMJ) glycomimetic core and different aglycones, in either mono or multivalent displays, elicit binding modes involving glycone and nonglycone enzyme regions that reinforce the protein folding and stabilization potential. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00153DOI Listing

Ultrathin Polyamide Nanofiltration Membrane Fabricated on Brush-Painted Single-Walled Carbon Nanotube Network Support for Ion Sieving.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Recently, polyamide membranes with nanomaterials coated supports were reportedly overcoming the limitation of conventional supports and thus opening a new insight on the formation of ultrathin polyamide layer with unprecedented high separation performance. However, the feasibility of the new generation nanomaterials coated supports for stable large-scale polyamide membrane fabrication is still unclear. Herein, we report a simple and highly controllable large-scale fabrication technique for single-walled carbon nanotube (SWCNT) coated support membranes, where the SWCNT interlayer was prepared via large area brush painting. Read More

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http://dx.doi.org/10.1021/acsnano.8b09761DOI Listing

Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.

Int J Mol Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via deacetylation. As they serve a necessary function in inflammation and metabolism, SIRTs are considered to link inflammation and metabolic syndrome. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4173DOI Listing

IL-17A Inhibitor Switching - Efficacy of Ixekizumab Following Secukinumab Failure. A Single-Center Experience.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Rabin Medical Center - Beilinson Hospital, 4941492 Petach, Israel.

Interleukin-17A inhibitors are a promising alternative to tumor necrosis factor-α inhibitors for the treatment of psoriasis. In-class switch has been hardly investigated for interleukin-17A inhibitors. We report the experience (2017-2018) of a tertiary medical center with interleukin-17A-inhibitor switch in patients with moderate-to-severe psoriasis. Read More

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http://dx.doi.org/10.2340/00015555-3200DOI Listing

Records of breeding in Wilson's Plover Charadrius wilsonia with new localities for Brazil.

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Biologia, Programa de Pós-graduação em Etinobiologia e Conservação da Natureza - PPGEtno, Universidade Federal Rural de Pernambuco - UFRPE, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, CEP 52171-900, Recife, PE, Brasil.

Wilson's Plover, Charadrius wilsonia, is widely distributed in coastal areas of the Americas. This report presents the first record of breeding in this species on Coroa do Avião Island, on the coast of Pernambuco, and in the estuary of the Cardoso and Camurupim rivers, on the coast of Piauí, in northeastern Brazil, extending the known area of reproduction of this species in this region. One breeding pair was observed on October 29th 2014 on Coroa do Avião Island, and a second pair was recorded on April 6th 2016 in the Cardoso/Camurupim estuary on the Piauí coast. Read More

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http://dx.doi.org/10.1590/1519-6984.191183DOI Listing

Germination of Crotalaria and Lupinus (Fabaceae) seeds submitted to different pre-germination treatments and their effect on enzymatic activity during early germination.

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Laboratório de Fisiologia Vegetal, Pós-graduação em Produção Agroalimentar nos Trópicos, Área Agrícola, Colegio de Postgraduados - CP, Campus Tabasco, Periférico Carlos A. Molina, s/n, 86500, H. Cárdenas, Tabasco, México.

Most of the wild and native legume seeds has a hard and impermeable testa, which causes physical dormancy and prevents them from germinating even when environmental conditions are favorable. The study evaluated the effect of scarification treatments on germination and enzymatic activity of Crotalaria longirostrata (Cl) and Lupinus exaltatus (Le) seeds. After scarification treatments, germination percentage (GP) and rate (GR) were assessed during 30 days after seeding (DAS); and water absorption (WA) and specific enzymatic activity (SEA) during early germination (0, 6, 18, 36, 72, 120 h) in a growing chamber at 25 °C and photoperiod of 12 h. Read More

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http://dx.doi.org/10.1590/1519-6984.185813DOI Listing

Nursing theories in the conceptual expansion of good practices in nursing.

Rev Bras Enferm 2019 Mar-Apr;72(2):577-581. Epub 2019 Apr 18.

Universidade Federal do Rio de Janeiro, Escola de Enfermagem Anna Nery. Rio de Janeiro-RJ, Brasil.

Objective: To discuss the contribution of nursing theories in the conceptual expansion of good practices in the area for the construction of the unified health system (Sistema Único de Saúde - SUS).

Method: Theoretical production of reflection, based on the neomodern framework of philosophy of science.

Results: The knowledge and political, social and epistemological commitments of nursing are discussed, highlighting the relationship of the theories with good practices for the construction and application of knowledge in the area in the context of the Brazilian health care system. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0395DOI Listing

Translation and cultural adaptation of Patient Perceptions of Hemodialysis Scale in Brazil.

Rev Bras Enferm 2019 Mar-Apr;72(2):314-320. Epub 2019 Apr 18.

Federal University of São Carlos São Carlos-SP, Brazil.

Objective: To translate and adapt the Patient Perceptions of Hemodialysis Scale (PPHS) to the Brazilian context.

Method: A methodological study, in which the stages of initial translation, synthesis of translations, back translation, evaluation by an expert committee and pre-test of the PPHS were performed.

Results: Two initial translations by independent translators, experienced in the health area and fluent in English. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0052DOI Listing
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