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Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Sub-analysis of a prospective, randomized, controlled study (PRIME-V study).

J Diabetes Investig 2020 Jul 4. Epub 2020 Jul 4.

Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, 260-8677, Japan.

Introduction: Recent randomized clinical trials have suggested that sodium-glucose co-transporter-2 (SGLT2) inhibitors may reduce cardiovascular events and heart failure and have renal protective effects. Despite these remarkable benefits, the effects of SGLT2 inhibitors on bone and muscle are unclear.

Methods: A sub-analysis of a randomized controlled study was performed to evaluate the effects of the SGLT2 inhibitor, ipragliflozin, versus metformin on bone and muscle in Japanese patients with type 2 diabetes mellitus (baseline BMI ≥ 22 kg/m and HbA1c 7-10 %) who were already receiving sitagliptin. Read More

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http://dx.doi.org/10.1111/jdi.13340DOI Listing

Launching a public statewide tele(oral)medicine service in Brazil during COVID-19 pandemic.

Oral Dis 2020 Jul 5. Epub 2020 Jul 5.

Brazilian Institute for Digital Convergence, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

The State of Santa Catarina is located in the South of Brazil, covering an area of 95,730 km , and is divided into 295 municipalities, with an estimated population of 7.164.788 inhabitants. Read More

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http://dx.doi.org/10.1111/odi.13528DOI Listing

Impact of an extended postnatal home visiting programme on oral health among children in a disadvantaged area of Stockholm, Sweden.

Acta Paediatr 2020 Jul 4. Epub 2020 Jul 4.

Division of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Aim: To evaluate oral health outcomes and early oral health promotion of children in a Swedish, parental support programme conducted in a collaboration between Child Health Services and Social Services.

Methods: The intervention offered first-time parents six home visits from a paediatric nurse and a parental advisor with Social Services. On the fourth visit (infant age 6-8 months), parents received a toothbrush and fluoride toothpaste from non-dental staff. Read More

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http://dx.doi.org/10.1111/apa.15457DOI Listing

Methyl aminolevulinate photodynamic therapy for Bowen's disease on the fingers - Is monotherapy sufficiently effective?

Photodermatol Photoimmunol Photomed 2020 Jul 5. Epub 2020 Jul 5.

Medical University of Graz, Department of Dermatology and Venereology.

Bowen's disease (BD), also known as squamous cell carcinoma (SCC) in situ, most commonly involves the head and neck area as well as the extremities (1), but little epidemiological data exists about its prevalence on the fingers. Several treatment modalities are available for BD, including surgical excision, photodynamic therapy (PDT), topical 5-fluorouracil, imiquimod, and cryotherapy, but no single therapy has been proven to be superior to others.(2) Several case reports have previously shown that PDT may be an effective treatment for BD on the fingers. Read More

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http://dx.doi.org/10.1111/phpp.12586DOI Listing

Paediatric emergency department visits fell by more than 70% during the COVID-19 lockdown in Northern Italy.

Acta Paediatr 2020 Jul 4. Epub 2020 Jul 4.

Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

In February 2020 the COVID-19 pandemic flared up across Italy and the first cluster appeared in Southern Lombardy, which is still the most affected area (1). Schools. sports facilities and parks were closed on 1 March, followed by a strict lockdown on 10 March after a significant increase in infections and deaths. Read More

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http://dx.doi.org/10.1111/apa.15458DOI Listing

Assessing the current state of ecological connectivity in a large marine protected area system.

Conserv Biol 2020 Jul 5. Epub 2020 Jul 5.

School of BioSciences, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

The establishment of marine protected areas (MPAs) is a critical step in ensuring the continued persistence of marine biodiversity. While the area protected within MPAs is growing, the movement of individuals (or larvae) among MPAs, termed connectivity, has only recently been included as an objective of many MPAs. As such, assessing connectivity is often neglected or over-simplified in the planning process. Read More

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http://dx.doi.org/10.1111/cobi.13580DOI Listing

Expression of synaptophysin and BDNF in the medial prefrontal cortex following early life stress and neonatal hypoxia-ischemia.

Dev Psychobiol 2020 Jul 4. Epub 2020 Jul 4.

Laboratory of Experimental Physiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

This study aims at investigating whether early stress interacts with brain injury due to neonatal hypoxia-ischemia (HI). To this end, we examined possible changes in synaptophysin (SYN) and brain-derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC) of maternally separated rats that were subsequently exposed to a HI episode. Rat pups (n = 11) were maternally separated during postnatal days 1 to 6 (3hr/day), while another group was left undisturbed (n = 11). Read More

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http://dx.doi.org/10.1002/dev.22011DOI Listing

Waterborne agrichemicals compromise the anti-predatory behavior of zebrafish.

Environ Sci Pollut Res Int 2020 Jul 4. Epub 2020 Jul 4.

Programa de Pós-Graduação em Ciências Ambientais, Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.

Due to human activities, there is an increasing presence of agrochemicals residues in water bodies, which could be attributed to an increased use of these chemicals, incorrect disposal of packaging materials, and crop leaching. The effects of these residues on prey-predator relationship of aquatic animals are poorly known. Here, we show that fish acutely exposed to glyphosate, 2,4-D, and methylbenzoate-based agrichemicals have their anti-predatory responses impaired. Read More

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http://dx.doi.org/10.1007/s11356-020-09862-2DOI Listing

Evaluation of the Swat River, Northern Pakistan, water quality using multivariate statistical techniques and water quality index (WQI) model.

Environ Sci Pollut Res Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Environmental Sciences, University of Haripur, Haripur, 26620, Pakistan.

This study evaluates the characteristics of water along the Swat River, Northern Pakistan. For this purpose, water samples (n = 30) were collected and analyzed for physicochemical parameters including heavy metals (HM). The mean concentrations of physicochemical parameters and HM were within the drinking water guideline values set by the World Health Organization (WHO 2011) except 34%, 60%, and 56% of copper (Cu), nickel (Ni), and lead (Pb), respectively. Read More

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http://dx.doi.org/10.1007/s11356-020-09688-yDOI Listing

The impact of polycystic ovary syndrome and body mass index on the absorption of recombinant human follicle stimulating hormone.

J Assist Reprod Genet 2020 Jul 4. Epub 2020 Jul 4.

Brigham and Women's Hospital Center for Infertility and Reproductive Surgery, Harvard Medical School, 75 Francis Street, Boston, MA, USA.

Purpose: Women with polycystic ovary syndrome (PCOS) have an increased ovarian responsiveness to exogenous recombinant follicle stimulating hormone (rFSH) but also have high rates of obesity, which is known to affect serum FSH concentrations following exogenous injection. The purpose of this study was to compare rFSH absorption and ovarian response between lean and overweight/obese PCOS subjects and normo-ovulatory controls.

Methods: Fourteen women with PCOS aged 18-42 years old with a BMI of 18. Read More

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http://dx.doi.org/10.1007/s10815-020-01865-9DOI Listing

Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Harvard Medical School, Boston, MA, USA.

Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory conditions, towards the development of cardiovascular disease has garnered considerable interest. Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease, but risk of cardiovascular disease amongst patients with cutaneous lupus is less well known. Read More

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http://dx.doi.org/10.1007/s10067-020-05257-3DOI Listing

Systemic immune-inflammation index combined with ferritin can serve as a reliable assessment score for adult-onset Still's disease.

Clin Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

Objective: The diagnosis of adult-onset Still's disease (AOSD) is based on nonspecific symptoms and laboratory data, and several infectious, autoimmune, and malignant diseases must be ruled out. This study aimed to elucidate the value of various laboratory inflammatory scores, including the systemic immune-inflammation index (SII), C-reactive protein/albumin ratio (CAR), albumin/globulin ratio (AGR), prognostic nutritional index (PNI), and ferritin/erythrocyte sedimentation rate ratio (FER) as assessment factors for diagnosis and evaluation of disease activity in AOSD.

Methods: The medical records of patients suspected of AOSD between January 1999 and June 2019 were examined. Read More

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http://dx.doi.org/10.1007/s10067-020-05266-2DOI Listing

Restoration of euthyroidism in women with Hashimoto's thyroiditis changes bone microarchitecture but not estimated bone strength.

Endocrine 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Purpose: Fracture risk in hypothyroid patients is debated, and since the effects of hypothyroidism on bone microarchitecture and strength are unclarified, we investigated these characteristics by high-resolution peripheral quantitative computed tomography (HR-pQCT).

Methods: Two approaches were used: a cross-sectional control study, comparing 32 hypothyroid women (mean age; 47 ± 12 years) suffering from Hashimoto's thyroiditis with 32 sex-, age-, and menopause-matched healthy controls; a prospective study, where 27 of the women were reexamined 1 year after restoration of euthyroidism. HR-pQCT of the distal radius and tibia, and dual-energy X-ray absorptiometry (DXA) of the spine and hip were performed. Read More

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http://dx.doi.org/10.1007/s12020-020-02398-yDOI Listing

Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro.

Arch Toxicol 2020 Jul 4. Epub 2020 Jul 4.

Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090, Vienna, Austria.

Molds of the genus Alternaria produce several mycotoxins, some of which may pose a threat for health due to their genotoxicity. Due to the lack of adequate toxicological and occurrence data, they are currently not regulated. Interactions between mycotoxins, gut microbiota and food constituents might occur after food ingestion, modifying the bioavailability and, therefore, overall toxicity of mycotoxins. Read More

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http://dx.doi.org/10.1007/s00204-020-02831-1DOI Listing

Exploratory study on the presence of bisphenol A and bis(2-ethylhexyl) phthalate in the Santa Catarina River in Monterrey, N.L., Mexico.

Environ Monit Assess 2020 Jul 4;192(8):488. Epub 2020 Jul 4.

Universidad Autónoma de Chihuahua, Facultad de Ingeniería, UACH-CA-115, Circuito Universitario, Campus II, 31124, Chihuahua, Chih, Mexico.

The current problem related to the supply of drinking water for the metropolitan area of Monterrey, which comprises of five million inhabitants, and the important role played by the El Cuchillo Dam, found downstream of the Santa Catarina River basin as a surface source of drinking water for the city, renders this river an interesting site for assessment. This work evaluates the degree to which the surface water and the subsoil of the river are affected by emerging organic pollutants due to their existence, even at low concentrations, representing a toxic risk enhanced by the absence of stricter standards for regulating these substances. Based on fieldwork, three discharge points that could affect the quality of the surface water were selected: two points on the river stream, and three groundwater wells. Read More

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http://dx.doi.org/10.1007/s10661-020-08446-4DOI Listing

Matrix Metalloproteinases (MMP-2) and Tissue Inhibitors of Metalloproteinases (TIMP-2) in Patients with Inguinal Hernias.

World J Surg 2020 Jul 4. Epub 2020 Jul 4.

Department of Hernia and Abdominal Wall Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China.

Background: The development of inguinal hernia might be related with collagen metabolism, which was regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). The aim of this study was to evaluate the mRNA and protein expression levels of MMP-2 and TIMP-2 in anterior rectus sheath fascia to investigate the function of them in inguinal hernia formation.

Methods: The study enrolled 48 primary inguinal hernia patients: 32 participants had indirect inguinal hernia and 16 patients suffered direct inguinal hernia. Read More

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http://dx.doi.org/10.1007/s00268-020-05674-0DOI Listing

Agent-based modelling and parameter sensitivity analysis with a finite-element method for skin contraction.

Biomech Model Mechanobiol 2020 Jul 4. Epub 2020 Jul 4.

Delft Institute of Applied Mathematics, Delft University of Technology, Van Mourik Broekmanweg 6, 2628 XE, Delft, The Netherlands.

In this paper, we extend the model of wound healing by Boon et al. (J Biomech 49(8):1388-1401, 2016). In addition to explaining the model explicitly regarding every component, namely cells, signalling molecules and tissue bundles, we categorized fibroblasts as regular fibroblasts and myofibroblasts. Read More

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http://dx.doi.org/10.1007/s10237-020-01354-zDOI Listing

The role of MRI pelvimetry in predicting technical difficulty and outcomes of open and minimally invasive total mesorectal excision: a systematic review.

Tech Coloproctol 2020 Jul 4. Epub 2020 Jul 4.

Surgical Outcomes Research Centre (SOuRCe), Sydney, Australia.

Background: The difficulty of performing total mesorectal excision (TME) for rectal cancer partly relies on the surgeon's subjective assessment of the individual patient's pelvic anatomy and tumour characteristics, which generally influences the choice of platform used (open, laparoscopic, robotic or trans-anal surgery). Recent studies have found associations between several anatomical pelvic measurements and surgical difficulty. The aim of this study was to systematically review existing data reporting the use of magnetic resonance imaging (MRI)-based pelvic measurements to predict technical difficulty and outcomes of TME, and determine whether pelvimetry could optimise patient-specific selection of a particular surgical approach. Read More

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http://dx.doi.org/10.1007/s10151-020-02274-xDOI Listing

Comprehensive evaluation of Ga-PSMA-11 PET/CT parameters for discriminating pathological characteristics in primary clear-cell renal cell carcinoma.

Eur J Nucl Med Mol Imaging 2020 Jul 4. Epub 2020 Jul 4.

Department of Urology, Nanjing Drum Tower Hospital, Institute of Urology Nanjing University, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.

Purpose: To evaluate parameters derived from Ga-PSMA-11 PET/CT images for discriminating pathological characteristics in primary clear-cell renal cell carcinoma (ccRCC).

Methods: The study retrospectively examined data for 36 ccRCC patients with preoperative Ga-PSMA-11 PET/CT scan and surgical specimens. Radiological parameters including maximal tumor diameter, mean CT value, and maximal standard uptake value (SUV) were derived from PET/CT images. Read More

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http://dx.doi.org/10.1007/s00259-020-04916-6DOI Listing

Bone microstructure of adult patients with non-surgical hypoparathyroidism assessed by high-resolution peripheral quantitative computed tomography.

Osteoporos Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China.

There is limited evidence regarding changes in bone microstructure in patients with hypoparathyroidism. In the current study, we used a non-invasive technique to assess bone structure in hypoparathyroidism patients and discovered site-specific changes which were mainly influenced by age and menstrual status. Such changes were more prominent in the trabeculae as well as in non-surgical as opposed to post-surgical patients. Read More

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http://dx.doi.org/10.1007/s00198-020-05506-wDOI Listing

Complex Gait Is Related to Cognitive Functioning in Older People: A Cross-Sectional Study Providing an Innovative Test.

Gerontology 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Didactic of Music, Plastic and Body Expression, University of Jaén, Jaén, Spain.

Background: Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CGT performance and physical functioning and cognitive measures.

Methods: A total of 279 older people (60-97 years) were analyzed in 2019. Read More

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http://dx.doi.org/10.1159/000508245DOI Listing

Serum interleukin-8 as a potential diagnostic biomarker in esophageal squamous cell carcinoma.

Cancer Biomark 2020 Jun 24. Epub 2020 Jun 24.

The Cancer Hospital of Shantou University Medical College, Guangdong, China.

Background: Esophageal squamous cell carcinoma (ESCC) has poor prognosis mainly due to the difficulty of making early diagnosis. Therefore, novel biomarkers are critically needed.

Objective: We aimed to investigate the diagnostic value of serum interleukin-8 (IL-8) in ESCC. Read More

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http://dx.doi.org/10.3233/CBM-201687DOI Listing

Long intergenic noncoding RNA LINC00173 as a potential serum biomarker for diagnosis of non-small-cell lung cancer.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Background: Long intergenic non-coding RNA (lincRNA) belongs to a special type of RNA that is unable to encode proteins but has been proved to play a role in gene regulation and differentially expressed in various malignant tumors.

Objective: In this study, we aimed to identify whether lincRNA LINC00173 was differentially expressed in non-small-cell lung cancer (NSCLC) and whether it could serve as a potential diagnostic biomarker.

Methods: The quantification real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression of LINC00173 in serum and cultured cells. Read More

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http://dx.doi.org/10.3233/CBM-201616DOI Listing

The clinical significance of Interleukin 24 and its potential molecular mechanism in laryngeal squamous cell carcinoma.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Research, Guangxi Medical University Cancer Hospital, Guangxi, China.

Interleukin 24 (IL24) has been documented to be highly expressed in several cancers, but its role in laryngeal squamous cell carcinoma (LSCC) remains unclarified. In this study, to reveal the function and its clinical significance of IL24 in LSCC, multiple detecting methods were used comprehensively. IL24 protein expression was remarkably higher in LSCC (n= 49) than non-cancerous laryngeal controls (n= 26) as detected by in-house immunohistochemistry. Read More

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http://dx.doi.org/10.3233/CBM-201441DOI Listing

Multiple sclerosis with intractable vomiting and atypical area postrema lesion.

Mult Scler Relat Disord 2020 Jul 1;45:102348. Epub 2020 Jul 1.

National Neuroscience Institute of Singapore, Singapore. Electronic address:

Background: Area postrema syndrome is considered as one of the most typical presentations of neuromyelitis optica spectrum disorders (NMOSDs) (Wingerchuk et al., 2015). The involvement of area postrema is rarely seen in multiple sclerosis (MS). Read More

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http://dx.doi.org/10.1016/j.msard.2020.102348DOI Listing

Cardiogenic cerebral infarction in the parietal lobe predicts the development of post-stroke epilepsy.

Seizure 2020 Jun 20;80:196-200. Epub 2020 Jun 20.

Department of Neurology, Iizuka Hospital, 3-83 Yoshio-machi, Iizuka, 820-8505, Fukuoka, Japan. Electronic address:

Purpose: Post-stroke epilepsy (PSE) is a major late complication of cardioembolic cerebral infarction. However, few studies have examined the epileptogenicity and characteristics of first-occurrence cardioembolic cerebral infarctions.

Methods: This retrospective study included 93 consecutive patients with old cardioembolic cerebral infarctions who were classified into two groups based on their epileptic history: patients presenting with PSE or stroke without seizure (SWS). Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.018DOI Listing

Does power ultrasound (26 kHz) affect the hydrogen evolution reaction (HER) on Pt polycrystalline electrode in a mild acidic electrolyte?

Ultrason Sonochem 2020 Jun 26;69:105238. Epub 2020 Jun 26.

Hydrogen Energy and Sonochemistry Research Group, Department of Energy and Process Engineering, Faculty of Engineering, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway.

In this study, we investigated the effects of power ultrasound (26 kHz, up to ∼75 W/cm, up to 100% acoustic amplitude, ultrasonic horn) on the hydrogen evolution reaction (HER) on a platinum (Pt) polycrystalline disc electrode in 0.5 M HSO by cyclic and linear sweep voltammetry at 298 K. We also studied the formation of molecular hydrogen (H) bubbles on a Pt wire in the absence and presence of power ultrasound using ultra-fast camera imaging. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105238DOI Listing

The gluteus maximus V-Y advancement flap for reconstruction of extensive soft tissue loss following an advanced sacral pressure ulcer. A case report and mini review.

Int J Surg Case Rep 2020 Jun 17;73:15-21. Epub 2020 Jun 17.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Cameroon. Electronic address:

Background: The occurrence of pressure injuries (PIs) in an inpatient is a serious medical condition that requires a rigorous clinical evaluation. Management of these lesions should be comprehensive, including general measures and local care. Wound care occupies a large part of the treatment. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.060DOI Listing

Real-time conflict-based Bayesian Tobit models for safety evaluation of signalized intersections.

Accid Anal Prev 2020 Jul 2;144:105660. Epub 2020 Jul 2.

Department of Civil Engineering, University of British Columbia, 6250 Applied Science Lane, Vancouver, BC, V6T 1Z4, Canada. Electronic address:

The safety of signalized intersections has traditionally been evaluated at an aggregate level by relating historical collision records for several years to the annual traffic volume and the geometric characteristics of the intersection. This is a reactive and macroscopic approach that gives little insight into how important dynamic signal cycle-related variables can affect intersection safety such as the arrival type and the shock wave characteristics. The objective of this study is to develop traffic conflict-based real-time safety models for signalized intersections using several state-of-the-art techniques. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105660DOI Listing

Deep learning evaluation of pelvic radiographs for position, hardware presence, and fracture detection.

Authors:
Gene Kitamura

Eur J Radiol 2020 Jun 21;130:109139. Epub 2020 Jun 21.

University of Pittsburgh. University of Pittsburgh Medical Center (UPMC)Department of Radiology, 200 Lothrop St., UPMC Montefiore, Room NE 538, Pittsburgh, PA 15213, United States. Electronic address:

Purpose: Recent papers have shown the utility of deep learning in detecting hip fractures with pelvic radiographs, but there is a paucity of research utilizing deep learning to detect pelvic and acetabular fractures. Creating deep learning models also requires appropriately labeling x-ray positions and hardware presence. Our purpose is to train and test deep learning models to detect pelvic radiograph position, hardware presence, and pelvic and acetabular fractures in addition to hip fractures. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109139DOI Listing

The response of the mental health network of the Salamanca area to the COVID-19 pandemic: The role of the telemedicine.

Psychiatry Res 2020 Jul 1;291:113252. Epub 2020 Jul 1.

Psychiatry Service, University of Salamanca Healthcare Complex (USHC), Salamanca, Spain; Institute of Biomedicine of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain; School of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain.

The COVID-19 pandemic reached world-wide causing a great impact on healthcare services. The aim of this work is to describe the response of the Mental Health Network of the Salamanca´ Area (Spain) to this crisis and the reorganization of its resources within the first 8 weeks after the state of alarm was declared. The Psychiatry Service applied a contingency plan which included the reorganization of the human resources, the closure of some of the units and the implementation of telemedicine programs along with two specific programs, namely a mental health assistance program in the context of the infection by coronavirus, and another program for homeless people. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329660PMC

Dynamic Infrared Thermography (DIRT) in DIEP flap breast reconstruction: A clinical study with a standardized measurement setup.

Eur J Obstet Gynecol Reprod Biol 2020 May 30;252:166-173. Epub 2020 May 30.

Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, Multidisciplinary Breast Clinic, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B-2650, Antwerp, Belgium.

Objective: Breast reconstructions with perforator flaps from the lower abdomen, commonly known as Deep Inferior Epigastric artery Perforator flap (DIEP-flap), have become the golden standard for autologous breast reconstruction after breast amputation. During this surgical procedure multiple challenging steps are encountered such as the selection of a suitable perforator that provides sufficient blood supply for the flap, surgical dissection of the chosen perforator, determination of perfusion area of the chosen perforator, microsurgical anastomosis, flap inset and shaping the flap into a breast. The current gold standard for perforator mapping is Computed Tomography Angiography (CTA). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.038DOI Listing

Non-target and suspect screening of per- and polyfluoroalkyl substances in Chinese municipal wastewater treatment plants.

Water Res 2020 Jun 19;183:115989. Epub 2020 Jun 19.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, People's Republic of China. Electronic address:

Wastewater treatment plant (WWTP) is one of the major sources of per- and polyfluoroalkyl substances (PFASs) to the aquatic environment. In this study, wastewater samples were collected from 17 WWTPs in 17 cities of China to investigate emerging PFASs in WWTPs. To comprehensively identify PFASs in the wastewater samples, an integrated suspect screening, homologue-based and fragment-based non-target screening method is proposed. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115989DOI Listing

Can groundwater be protected from the pressure of china's urban growth?

Environ Int 2020 Jul 2;143:105911. Epub 2020 Jul 2.

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, China; State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, China. Electronic address:

Groundwater is expected to be more vulnerable to water-quality degradation in the future due to rapid urbanization. However, despite knowledge that protecting future groundwater resources is necessary for sustainable groundwater resource development, little is known about the role of groundwater policy in influencing the spatial distribution of urbanization. This study sheds light on how a policy that protects vulnerable groundwater could affect the distribution of urban expansion. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105911DOI Listing

Nanostructured-membrane electron phase plates.

Ultramicroscopy 2020 Jun 25;217:113053. Epub 2020 Jun 25.

Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

Electron beams can acquire designed phase modulations by passing through nanostructured material phase plates. These phase modulations enable electron wavefront shaping and benefit electron microscopy, spectroscopy, lithography, and interferometry. However, in the fabrication of electron phase plates, the typically used focused-ion-beam-milling method limits the fabrication throughput and hence the active area of the phase plates. Read More

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http://dx.doi.org/10.1016/j.ultramic.2020.113053DOI Listing

STEM electron beam-induced current measurements of organic-inorganic perovskite solar cells.

Ultramicroscopy 2020 Jun 11;217:113047. Epub 2020 Jun 11.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Technological University, Singapore 639798, Singapore; Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C), Forschungszentrum Jülich, Jülich, 52425, Germany.

We describe a new approach for preparing organic-inorganic perovskite solar cells for electron beam-induced current (EBIC) measurements in plan-view geometry. This method substantially reduces sample preparation artefacts, provides good electrical contact and keeps the preparation steps as close as possible to those for real devices. Our EBIC images were acquired simultaneously with annular dark-field scanning transmission electron microscopy images using a home-made highly sensitive EBIC amplifier. Read More

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http://dx.doi.org/10.1016/j.ultramic.2020.113047DOI Listing

Response of protist community dynamics and co-occurrence patterns to the construction of artificial reefs: A case study in Daya Bay, China.

Sci Total Environ 2020 Jun 27;742:140575. Epub 2020 Jun 27.

South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China; National Fishery Resources and Environment Dapeng Observation and Experimental Station, Shenzhen 518120, China; Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 510300, China; Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environment, Ministry of Agriculture and Rural Affair, Guangzhou 510300, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China.

Artificial reefs (ARs) are widely used for biodiversity conservation and coastal habitat restoration. Although protists play an important ecological role in marine ecosystems, the response of the protist community to ARs is still poorly understood. In the current study, an Illumina sequencing analysis of 18S rDNA was performed, and the diversity, community structure, and co-occurrence networks of protists in the ARs and open sea area (OW) in Daya Bay were described. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140575DOI Listing

Degradation of nanoplastics in the environment: Reactivity and impact on atmospheric and surface waters.

Sci Total Environ 2020 Jun 20;742:140413. Epub 2020 Jun 20.

Institute for Atmospheric and Earth System Research/Physics, Faculty of Science, University of Helsinki, FI-00014, Finland; Dipartimento di Chimica, Università di Torino, Via Pietro Giuria 5, 10125 Torino, Italy. Electronic address:

Microplastics (MPs) and nanoplastics (NPs) are ubiquitous and contaminate soil, surface waters, atmospheric aerosol, precipitations, indoor and outdoor environments. However, the occurrence, transformation and fate of NPs in the environment are still unclear. In this work, polystyrene nanoparticles (PS-NPs) are used as a proxy of NPs to study their reactivity and potential impact on atmospheric and surface waters. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140413DOI Listing

Industrial structure, urban governance and haze pollution: Spatiotemporal evidence from China.

Sci Total Environ 2020 May 11;742:139228. Epub 2020 May 11.

School of Public Economics and Administration, Shanghai University of Finance and Economics, Shanghai 200433, PR China. Electronic address:

As a negative external product of China's rapid development, haze pollution has seriously affected the quality of economic development and people's quality of life. This paper firstly explores the important reasons for the uncoordinated industrial structure caused by haze pollution, and puts forward the purpose of promoting the adjustment of industrial structure through urban governance in order to tackle with the urgent problem of haze pollution. Using panel data from 287 cities in China, this paper analyzes the relationship among industrial structure, urban governance and haze pollution using the Geographically and Temporally Weighted Regression (GTWR) model. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139228DOI Listing

Military training exercises, pollution, and their consequences for health.

J Health Econ 2020 Jun 18;73:102345. Epub 2020 Jun 18.

University of Toronto, Canada.

Militaries around the world perform training exercises in preparation for war. We study the relationship between in utero exposure to military exercises (bombing) and early-life health outcomes, combining data on naval bombing exercises in Vieques, Puerto Rico, and the universe of births from 1990 to 2003. Using a differences-in-differences design, we find that the sudden end of bombing practices is associated with a 56-79% decrease in the incidence of congenital anomalies. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102345DOI Listing

Nanoplatelet interactions in the presence of multivalent ions: The effect of overcharging and stability.

J Colloid Interface Sci 2020 Jun 19;579:573-581. Epub 2020 Jun 19.

Theoretical Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden; LINXS - Lund Institute of Advanced Neutron and X-ray Science, Scheelevägen 19, SE-223 70 Lund, Sweden. Electronic address:

Hypothesis: The stability of colloidal dispersions in the presence of multivalent ions depends strongly on the electrostatic interactions between the suspended particles. Of particular interest are colloidal particles having dimensions in the nanometric range and with an anisotropic shape due to its high surface area per unit mass, for example clay, which has the key characteristic of a negatively charged surface, surrounded by an oppositely charged rim.

Experiments: In this study, we investigate the interactions in nanoplatelet dispersions for the model system of Laponite® clay with addition of mono- and multivalent salt. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.045DOI Listing

Integrated environmental evaluation of heavy metals and metalloids bioaccumulation in invertebrates and seaweeds from different marine coastal areas of sardinia, mediterranean sea.

Environ Pollut 2020 Jun 27;266(Pt 2):115048. Epub 2020 Jun 27.

Department of Life and Environmental Science, Food Toxicology Unit, University of Cagliari, University Campus of Monserrato, SS 554, 09042, Cagliari, Italy. Electronic address:

In this work, three gastropods Patella vulgata, Osilinus turbinata, and Tahis clavigera, one echinoderm Parancetrotus lividus, one coelenterate Anemonia sulcata, and two seaweed Padina pavonica, and Cystoseira mediterranea were collected from three different marine areas of Sardinia in the Mediterranean sea and studied for heavy metals and metalloid content and accumulation trends. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used for the determination of Al, AS, B, Ba, Be, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Sb, Se, Sn, Sr, Te, Ti, V and Zn in the selected samples. The results showed that gastropods were capable of accumulating Al, Ba, Cu, Fe, Sr, and Zn; seaweeds can better concentrate Al, Fe, and Zn than all other species. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115048DOI Listing

Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.

J Ethnopharmacol 2020 Jul 2:113127. Epub 2020 Jul 2.

CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, UP, India. Electronic address:

Ethno-pharmacological Relevance: Lavender oil (LO) is an aromatic/essential oil extracted from Lavandula angustifolia and traditionally used as an aromatherapy massage oil due to its anti-inflammatory and wound healing property and also for providing the relief in other skin conditions such as psoriasis, dermatitis and eczema. However, LO has not been evaluated scientifically for psoriasis like skin inflammation.

Aim Of The Study: This study aimed to investigate the LO and its major components linalool (L) and linalyl acetate (LA) against psoriasis like skin inflammation. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113127DOI Listing

Identifying a supramodal language network in human brain with individual fingerprint.

Neuroimage 2020 Jul 2:117131. Epub 2020 Jul 2.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University & IDG/McGovern Institute for Brain Research, Beijing, 100875, China. Electronic address:

Where is human language processed in the brain independent of its form? We addressed this issue by analyzing the cortical responses to spoken, written and signed sentences at the level of individual subjects. By applying a novel fingerprinting method based on the distributed pattern of brain activity, we identified a left-lateralized network composed by the superior temporal gyrus/sulcus (STG/STS), inferior frontal gyrus (IFG), precentral gyrus/sulcus (PCG/PCS), and supplementary motor area (SMA). In these regions, the local distributed activity pattern induced by any of the three language modalities can predict the activity pattern induced by the other two modalities, and such cross-modal prediction is individual-specific. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117131DOI Listing

Graphene nanoribbons: A promising nanomaterial for biomedical applications.

J Control Release 2020 Jul 2. Epub 2020 Jul 2.

College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode 673008, Kerala, India. Electronic address:

Graphene nanoribbons (GNRs) are narrow lengthened strips of single-layer graphene. Among the graphene family of nanomaterials, GNRs are remarkable materials due to their attractive physical, chemical, electrical, mechanical, thermal, and optical properties. They have an ultra-high surface area. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.034DOI Listing

Predictors of progression from moderate to severe COVID-19: a retrospective cohort.

Clin Microbiol Infect 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430021, Hubei, China. Electronic address:

Objective: Most coronavirus disease 2019 (COVID-19) cases were identified as moderate, which is defined as having a fever or dry cough and lung imaging with ground-glass opacities. The risk factors and predictors of prognosis in such cohorts remain uncertain.

Methods: All adult patients with COVID-19 of moderate severity diagnosed using qRT-PCR and hospitalized at the Central Hospital of Wuhan, China, from Jan 1 to Mar 20, 2020 were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.033DOI Listing

Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease.

Life Sci 2020 Jul 2:118037. Epub 2020 Jul 2.

Department of Life Sciences and Biotechnology, University of Ferrara, Via Borsari, 36-44121 Ferrara, Italy.

Palmitoylethanolamide (PEA) is an endogenous lipid mediator that, also by blunting astrocyte activation, demonstrated beneficial properties in several in vitro and in vivo models of Alzheimer's disease (AD). In the present study, we used astrocyte-neuron co-cultures from 3xTg-AD mouse (i.e. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118037DOI Listing

Outcomes of Totally Endoscopic Beating-Heart Tricuspid Repair in Redo Cardiac Surgery.

Heart Lung Circ 2020 Jun 14. Epub 2020 Jun 14.

Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China. Electronic address:

Background: The role of endoscopic surgery in treating late severe tricuspid regurgitation after cardiac surgery has not been well investigated. The aim of this study was to evaluate the outcomes of a combination of a beating-heart, minimally invasive approach and a leaflet-augmentation technique in treating tricuspid regurgitation after cardiac surgery.

Method: This was a retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.05.100DOI Listing

Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis.

Bone 2020 Jul 2:115522. Epub 2020 Jul 2.

Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China. Electronic address:

Objective: To explore the role of cellular communication network factor 1 (CCN1) in cartilage inflammaging and osteoarthritis (OA) pathogenesis in the isolated primary human chondrocytes in vitro, cartilage explants ex vivo, and a pre-clinical mice model.

Methods: Recombinant human CCN1 stimulation and small interfering RNA inhibition were conducted in human chondrocytes. The RNA was extracted to quantify catabolic targets and pro-inflammatory genes and the proteins were probed with specific antibodies. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115522DOI Listing

Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair.

Bone 2020 Jul 2:115524. Epub 2020 Jul 2.

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Suite 2000, Los Angeles, CA 90033, United States of America. Electronic address:

Background: The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects.

Methods: Critical-sized femoral defects created surgically in immunocompromised rats were treated with ASCs transduced with a lentivirus encoding BMP-2 (Group 1, n = 14), or green fluorescent protein (Group 2, n = 5), nontransduced ASCs (Group 3, n = 5), or rhBMP-2 (Group 4, n = 14). Read More

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http://dx.doi.org/10.1016/j.bone.2020.115524DOI Listing
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