4,442 results match your criteria Archivum immunologiae et therapiae experimentalis[Journal]


WNT7A Expression is Downregulated in T Lymphocytes after T-Cell Receptor Activation Due to Histone Modifications and in T-ALL by DNA Methylation.

Arch Immunol Ther Exp (Warsz) 2020 May 26;68(3):18. Epub 2020 May 26.

División de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada #800, Guadalajara, Jalisco, Mexico.

WNT signaling pathway regulates several processes involved in the homeostasis of normal cells. Its dysregulation is associated with pathological outcomes like cancer. We previously demonstrated that downregulation of WNT7A correlates with higher proliferation rates in acute lymphoblastic leukemia. Read More

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http://dx.doi.org/10.1007/s00005-020-00583-5DOI Listing

Decreased Serum Adiponectin Reflects Low Vitamin D, High Interleukin 6, and Poor Physical Performance in Knee Osteoarthritis.

Arch Immunol Ther Exp (Warsz) 2020 May 24;68(3):16. Epub 2020 May 24.

Department of Orthopaedics, Vinai Parkpian Orthopaedic Research Center, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand.

Obesity is a major contributor to deterioration of physical function toward sarcopenia in knee osteoarthritis (OA) due to its effect mediated through adipokines-derived molecules that have pro-/anti-inflammatory properties. This study aimed to investigate relationships of serum adiponectin, 25-hydroxyvitamin D (25(OH)D), interleukin (IL)-6, and physical performance in knee OA patients. A total of 175 knee OA patients and 52 healthy controls were recruited. Read More

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http://dx.doi.org/10.1007/s00005-020-00580-8DOI Listing

Exopolysaccharide from Lactobacillus rhamnosus KL37 Inhibits T Cell-dependent Immune Response in Mice.

Arch Immunol Ther Exp (Warsz) 2020 May 25;68(3):17. Epub 2020 May 25.

Department of Immunology, Jagiellonian University Medical College, Czysta 18, 31-121, Kraków, Poland.

Exopolysaccharides (EPSs), major components of the bacterial biofilm, display strong strain-specific immunomodulatory properties. Previously, we have shown that crude EPS derived from Lactobacillus rhamnosus KL37 depresses the production of arthritogenic anti-collagen IgG and ameliorates collagen-induced arthritis (CIA) in DBA/1 mice, when lipopolysaccharide (LPS) was used as adjuvant. In this study, we used highly purified EPS from L. Read More

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http://dx.doi.org/10.1007/s00005-020-00581-7DOI Listing

BW5147 and Derivatives for the Study of T Cells and their Antigen Receptors.

Arch Immunol Ther Exp (Warsz) 2020 May 18;68(3):15. Epub 2020 May 18.

Department of Biomedical Research, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.

Like B cells, T cells can be immortalized through hybridization with lymphoma cells, a technique that has been particularly useful in the study of the T cell receptors (TCR) for antigen. In T cell hybridizations, the AKR mouse strain-derived thymus lymphoma BW5147 is by far the most popular fusion line. However, the full potential of this technology had to await inactivation of the productively rearranged TCR-α and -β genes in the lymphoma. Read More

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http://dx.doi.org/10.1007/s00005-020-00579-1DOI Listing

HLA-A and -B Type and Haplotype Frequencies in IgG Subclass Deficiency Subgroups.

Arch Immunol Ther Exp (Warsz) 2020 Apr 20;68(3):14. Epub 2020 Apr 20.

Southern Iron Disorders Center, Birmingham, AL, USA.

We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal IgG1/IgG3) and controls (1,321 for types; 751 for haplotypes). We selected types and haplotypes because their uncorrected frequencies differed significantly from controls in a previous adult IgGSD/common variable immunodeficiency cohort: A*24; B*14; B*35; B*40; B*49; B*50; B*58; B*62; A*01,B*08; A*02,B*44; A*02,B*60; A*03,B*07; A*03,B*14; A*03,B*44; A*31,B*40; and A*32,B*14. Read More

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http://dx.doi.org/10.1007/s00005-020-00572-8DOI Listing

Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes.

Arch Immunol Ther Exp (Warsz) 2020 Apr 15;68(2):13. Epub 2020 Apr 15.

Foundation of Research and Science Development, Warsaw, Poland.

Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. Read More

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http://dx.doi.org/10.1007/s00005-020-00578-2DOI Listing

Specific T-Cell Subsets Can Predict the Efficacy of Anti-TNF Treatment in Inflammatory Bowel Diseases.

Arch Immunol Ther Exp (Warsz) 2020 Apr 4;68(2):12. Epub 2020 Apr 4.

Department of Rheumatology and Immunology, Faculty of Medicine, Albert Szent-Györgyi Health Center, University of Szeged, Kálvária sgt. 57, Szeged, 6725, Hungary.

The effect of TNF-blockers on T-lymphocyte subsets is largely unknown in inflammatory bowel diseases (IBDs). The aim of the present study was to analyze the prevalence of T-cell subtypes and their correlation to therapeutic response. Sixty-eight patients with Crohn's disease (CD), 46 with ulcerative colitis (UC) were enrolled. Read More

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http://dx.doi.org/10.1007/s00005-020-00575-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128008PMC

Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease.

Arch Immunol Ther Exp (Warsz) 2020 Apr 1;68(2):10. Epub 2020 Apr 1.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Chronic inflammation of the gastrointestinal system is mediated by both the immune system activity and homeostasis, mainly through releasing of various cytokines and chemokines, as well as the transmigration of the inflammatory cells to the affected site. In between, macrophages are key mediators of the immune system, nearly located all over the gastrointestinal tract. Macrophages have vital influence on the inflammatory condition with both pro-inflammatory and anti-inflammatory functions. Read More

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http://dx.doi.org/10.1007/s00005-020-00576-4DOI Listing
April 2020
3.176 Impact Factor

In Vitro Immunological Effects of CXCR3 Inhibitor AMG487 on Dendritic Cells.

Arch Immunol Ther Exp (Warsz) 2020 Apr 1;68(2):11. Epub 2020 Apr 1.

Department of Hematology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

AMG 487 is the targeted blocker of chemokine receptor CXCR3 and improves inflammatory symptoms by blocking the inflammatory cycle. Here we investigated whether AMG 487 affects dendritic cell (DC) biology and function. The expression of co-stimulatory markers on DCs was reduced, indicating the semi-mature state of DC when AMG 487 was added throughout the in vitro differentiation period. Read More

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http://dx.doi.org/10.1007/s00005-020-00577-3DOI Listing

Food Allergy Insights: A Changing Landscape.

Arch Immunol Ther Exp (Warsz) 2020 Apr 1;68(2). Epub 2020 Apr 1.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

The panorama of food allergies (FA) has changed profoundly in recent years. In light of recent advances in knowledge of pathogenetic mechanisms and a greater attention to the multifaceted range of possible clinical manifestations, there is a need for a critical review of past classifications. Changes in nutrition, environment and lifestyles around the world are modifying the global FA epidemiology and new FA phenotypes are also emerging. Read More

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http://dx.doi.org/10.1007/s00005-020-00574-6DOI Listing

Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis.

Arch Immunol Ther Exp (Warsz) 2020 Apr 1;68(2). Epub 2020 Apr 1.

Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.

One of many hypotheses of psoriasis pathogenesis supposes an overexpression of heat shock proteins (Hsps) in different skin layers and systemic immunologic response to them. Hsp90 is one of the most abundant chaperone in eukaryotic cells. The number of studies concerning the role of Hsp90 and anti-Hsp90 antibodies in etiopathogenesis of various diseases is also constantly expanding. Read More

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http://dx.doi.org/10.1007/s00005-020-00573-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113222PMC

Correction to: Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis.

Arch Immunol Ther Exp (Warsz) 2020 Feb 20;68(1). Epub 2020 Feb 20.

ENT Department, School of Medicine, Medical University of Silesia in Katowice, Katowice, Poland.

The authors would like to correct the following error. Read More

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http://dx.doi.org/10.1007/s00005-020-00570-wDOI Listing
February 2020
3.176 Impact Factor

Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.

Arch Immunol Ther Exp (Warsz) 2020 Feb 19;68(1). Epub 2020 Feb 19.

Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, 266000, China.

Allergic rhinitis (AR) is an IgE-mediated inflammation which causes olfactory dysfunction. Antihistamines have been widely used to treat AR while few studies have investigated the effect of antihistamines on improving the sense of smell. In addition, the underlying mechanisms are not well elucidated. Read More

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http://dx.doi.org/10.1007/s00005-020-00569-3DOI Listing
February 2020

Autotransplantation of the Adipose Tissue-Derived Mesenchymal Stromal Cells in Therapy of Venous Stasis Ulcers.

Arch Immunol Ther Exp (Warsz) 2020 Feb 14;68(1). Epub 2020 Feb 14.

Research and Development Centre, Regional Specialist Hospital, Kamienskiego 73a, 51-154, Wroclaw, Poland.

Adipose tissue is a reliable source of mesenchymal stromal cells (MSC) for use in regenerative medicine. The aim of this pilot study was to describe the method, and assess the safety and the potential efficacy of transplantation of autologous adipose tissue-derived MSC for the treatment of chronic venous stasis ulcers. Study group consisted of 11 patients (mean age: 66. Read More

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http://dx.doi.org/10.1007/s00005-020-00571-9DOI Listing
February 2020

Can Interferon-γ Release Assays Be Useful for Monitoring the Response to Anti-tuberculosis Treatment?: A Systematic Review and Meta-analysis.

Arch Immunol Ther Exp (Warsz) 2020 Feb 3;68(1). Epub 2020 Feb 3.

Pediatric Infectious Disease Research Center, Children's Medical Center Hospital, Tehran University of Medical Sciences, Dr. Gharib Street, Keshavarz Boulevard, Tehran, Iran.

The number of studies which evaluated interferon-gamma release assays (IGRAs) results after anti-tuberculosis (TB) treatment has been rapidly increasing. The aim of this study was to investigate the potential use of IGRAs (QFT-GIT, T-SPOT.TB, QFT-Plus) in assessing the response to anti-TB treatment. Read More

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http://dx.doi.org/10.1007/s00005-020-00568-4DOI Listing
February 2020

Treatment with Lycopodium clavatum 200dH Intensifies Kidney and Liver Injury in Mice Infected with Toxoplasma gondii.

Arch Immunol Ther Exp (Warsz) 2020 Jan 21;68(1). Epub 2020 Jan 21.

Departamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil.

The effects of infection with Toxoplasma gondii vary from asymptomatic to the development of alterations in various organs (including the liver and kidneys) which may be irreversible, and lead to the death of the host. Whereas homeopathy is an alternative and effective method for treating various diseases, including those caused by protozoa, we questioned the effect of using Lycopodium clavatum in mice infected with T. gondii. Read More

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http://dx.doi.org/10.1007/s00005-020-00567-5DOI Listing
January 2020

Type III Interferons (Lambda Interferons) in Rheumatic Autoimmune Diseases.

Arch Immunol Ther Exp (Warsz) 2020 Jan 9;68(1). Epub 2020 Jan 9.

Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.

The last 2 decades have witnessed the discovery and characterization of a new family of cytokines with immunological characteristics similar to those described for type I interferons, type III or lambda interferons. Unraveling the molecular mechanisms underlying each type of interferon has allowed us to understand how some autoimmune diseases can be considered as interferonopathies. Under normal conditions, type III interferons play a key role in the defense against viruses by modulating the functioning of several types of innate and adaptive immune cells. Read More

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http://dx.doi.org/10.1007/s00005-019-00564-3DOI Listing
January 2020

HER2-Positive Breast Cancer Immunotherapy: A Focus on Vaccine Development.

Arch Immunol Ther Exp (Warsz) 2020 Jan 9;68(1). Epub 2020 Jan 9.

Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Clinical progress in the field of HER2-positive breast cancer therapy has been dramatically improved by understanding of the immune regulatory mechanisms of tumor microenvironment. Passive immunotherapy utilizing recombinant monoclonal antibodies (mAbs), particularly trastuzumab and pertuzumab has proved to be an effective strategy in HER2-positive breast cancer treatment. However, resistance to mAb therapy and relapse of disease are still considered important challenges in clinical practice. Read More

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http://dx.doi.org/10.1007/s00005-019-00566-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223380PMC
January 2020
3.176 Impact Factor

Modulatory Effect of the Euro-Lupus Low-Dose Intravenous Cyclophosphamide Regimen on Circulating Immune Cells in Systemic Lupus Erythematosus.

Arch Immunol Ther Exp (Warsz) 2019 Dec 16;67(6):415-425. Epub 2019 Oct 16.

Department of Immunology, Faculty of Medicine and Dentistry, Palacký University Olomouc, University Hospital Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.

A Euro-Lupus regimen of low-dose intravenous cyclophosphamide (CFA) is commonly used to treat severe organ manifestations of systemic lupus erythematosus (SLE), particularly lupus nephritis (LN). There are no data on the distributions and dynamics of immune cell populations in patients with various treatment outcomes. The circulating immune cells of 11 female SLE patients were assessed before and after Euro-Lupus regimen (cumulative dose of 3000 mg CFA) by flow cytometry together with those of 16 healthy women. Read More

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http://dx.doi.org/10.1007/s00005-019-00563-4DOI Listing
December 2019
2 Reads

Gut Microbiota in Neurological Disorders.

Arch Immunol Ther Exp (Warsz) 2019 Dec 1;67(6):375-383. Epub 2019 Oct 1.

Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland.

The incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD) is increasing throughout the world, but their pathogenesis remains unclear and successful treatment remains elusive. Bidirectional communications between the central nervous system and gut microbiota may play some role in the pathogenesis of the above disorders. Up to a thousand bacterial species reside in human intestine; they colonize the gut shortly after birth and remain for life. Read More

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http://dx.doi.org/10.1007/s00005-019-00561-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805802PMC
December 2019
1 Read

Retinoids as an Immunity-modulator in Dermatology Disorders.

Arch Immunol Ther Exp (Warsz) 2019 Dec 24;67(6):355-365. Epub 2019 Sep 24.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

The skin is the largest epithelial surface protecting the body from invading microbes. Vitamin A plays vital roles in the host defence of the skin, including promoting epithelial cell integrity, proliferation, and differentiation and even mediating immune responses. Furthermore, vitamin A derivatives, retinoid drugs, are widely used to treat skin diseases, such as acne and psoriasis. Read More

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http://dx.doi.org/10.1007/s00005-019-00562-5DOI Listing
December 2019
1 Read

Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis.

Arch Immunol Ther Exp (Warsz) 2019 Dec 18;67(6):427-432. Epub 2019 Sep 18.

Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.

Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case-control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. Read More

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http://dx.doi.org/10.1007/s00005-019-00560-7DOI Listing
December 2019
1 Read
3.176 Impact Factor

Correction to: Significance and Role of Pattern Recognition Receptors in Malignancy.

Arch Immunol Ther Exp (Warsz) 2019 Oct;67(5):351

Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.

The authors would like to correct the following error. Read More

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http://dx.doi.org/10.1007/s00005-019-00557-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732119PMC
October 2019

90th Birthday of Prof. Czesław Radzikowski.

Arch Immunol Ther Exp (Warsz) 2019 10 30;67(5):271. Epub 2019 Aug 30.

Laboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wrocław, Poland.

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http://dx.doi.org/10.1007/s00005-019-00558-1DOI Listing
October 2019

Clinical and Immunological Features of 78 Adult Patients with Primary Selective IgG Subclass Deficiencies.

Arch Immunol Ther Exp (Warsz) 2019 Oct 30;67(5):325-334. Epub 2019 Jul 30.

Program in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California at Irvine, Irvine, CA, USA.

The purpose of this study is to describe both clinical and immunological features in large cohort of adult patients with IgG subclass deficiency, and response to immunoglobulin therapy. This is a retrospective study of data obtained from electronic medical records and paper charts of 78 patients with IgG subclass deficiency seen and followed at our immunology clinics from 2010 to 2016. Both isolated selective IgG subclass deficiency as well as combined (two) subclass deficiencies were observed. Read More

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http://link.springer.com/10.1007/s00005-019-00556-3
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http://dx.doi.org/10.1007/s00005-019-00556-3DOI Listing
October 2019
1 Read

Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts.

Arch Immunol Ther Exp (Warsz) 2019 Dec 19;67(6):401-414. Epub 2019 Jul 19.

Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Ciszewskiego 8, 02-786, Warsaw, Poland.

Poxviruses utilize multiple strategies to prevent activation of extrinsic and intrinsic apoptotic pathways for successful replication. Mitochondrial heat shock proteins (mtHsps), especially Hsp60 and its cofactor Hsp10, are engaged in apoptosis regulation; however, until now, the influence of poxviruses on mtHsps has never been studied. We used highly infectious Moscow strain of ectromelia virus (ECTV) to investigate the mitochondrial heat shock response and apoptotic potential in permissive L929 fibroblasts. Read More

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http://dx.doi.org/10.1007/s00005-019-00554-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805811PMC
December 2019
6 Reads

Interleukin-1 Genotype in Periodontitis.

Arch Immunol Ther Exp (Warsz) 2019 Dec 19;67(6):367-373. Epub 2019 Jul 19.

Department of Periodontology, Medical University of Warsaw, Warsaw, Poland.

This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe periodontitis. The significance of this test for prevention of periodontitis and its therapy has been discussed. Read More

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http://dx.doi.org/10.1007/s00005-019-00555-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805812PMC
December 2019
1 Read

Role of Macrophages in Pregnancy and Related Complications.

Arch Immunol Ther Exp (Warsz) 2019 Oct 8;67(5):295-309. Epub 2019 Jul 8.

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.

Macrophages (MФs) are the leukocytes produced from differentiation of monocytes and are located in almost all tissues of human body. They are involved in various processes, such as phagocytosis, innate and adaptive immunity, proinflammatory (M1) and anti-inflammatory (M2) activity, depending on the tissue microenvironment. They play a crucial role in pregnancy, and their dysfunction or alteration of polarity is involved in pregnancy disorders, like preeclampsia, recurrent spontaneous abortion, infertility, intrauterine growth restriction, and preterm labor. Read More

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http://dx.doi.org/10.1007/s00005-019-00552-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140981PMC
October 2019
3 Reads

Induction of Chronic Subclinical Systemic Inflammation in Sprague-Dawley Rats Stimulated by Intermittent Bolus Injection of Lipopolysaccharide.

Arch Immunol Ther Exp (Warsz) 2019 Dec 5;67(6):385-400. Epub 2019 Jul 5.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

Chronic subclinical systemic inflammation has a key role in stimulating several chronic conditions associated with cardiovascular diseases, cancer, rheumatoid arthritis, diabetes, and neurodegenerative diseases. Hence, developing in vivo models of chronic subclinical systemic inflammation are essential to the study of the pathophysiology and to measure the immunomodulatory agents involved. Male Sprague-Dawley rats were subjected to intraperitoneal, intermittent injection with saline, or lipopolysaccharide (LPS) (0. Read More

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http://dx.doi.org/10.1007/s00005-019-00553-6DOI Listing
December 2019
5 Reads
3.176 Impact Factor

Adjuvant Allergen Fusion Proteins as Novel Tools for the Treatment of Type I Allergies.

Arch Immunol Ther Exp (Warsz) 2019 Oct 20;67(5):273-293. Epub 2019 Jun 20.

Vice President's Research Group: Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich Str. 51-59, 63225, Langen, Germany.

While acute allergic symptoms can be managed by emergency medication, to date, allergen-specific immunotherapy (SIT) with allergen extracts is the only available curative treatment option. However, the risk of anaphylactic reactions, long treatment duration, varying extract quality, and underrepresentation of certain allergens currently prevent many patients from successfully undergoing SIT. Novel strategies are needed to enhance efficacy, safety, and convenience of allergy treatment. Read More

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http://dx.doi.org/10.1007/s00005-019-00551-8DOI Listing
October 2019
9 Reads

Diverse Activity of IL-17 Cells in Chronic Skin and Mucosa Graft-Versus-Host Disease.

Arch Immunol Ther Exp (Warsz) 2019 Oct 8;67(5):311-323. Epub 2019 Jun 8.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114, Wroclaw, Poland.

Excessive inflammatory environment in a course of chronic graft-versus-host disease (cGvHD) is associated with T-cell trafficking into inflamed tissues. This study focused on the identification of IL-17-producing cells in the tissue biopsies of cGvHD patients. Forty-one biopsy specimens of cGvHD lesions of the skin (n = 27), gastrointestinal tract (n = 9) and oral mucosa (n = 5), examined in 24 patients, were morphologically defined according to the NIH criteria and analyzed for the presence of cellular infiltrations including: IL-17, FOXP3 and CCR6 cells. Read More

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http://dx.doi.org/10.1007/s00005-019-00549-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732123PMC
October 2019
24 Reads

CTLA-4 Expression Inversely Correlates with Kidney Function and Serum Immunoglobulin Concentration in Patients with Primary Glomerulonephritides.

Arch Immunol Ther Exp (Warsz) 2019 Oct 8;67(5):335-349. Epub 2019 Jun 8.

Department of Nephrology, Medical University of Lublin, Lublin, Poland.

Major causes of chronic kidney disease are primary proliferative and nonproliferative glomerulonephritides (PGN and NPGN). However, the pathogenesis of PGN and NPGN is still not fully understood. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a T-cell membrane receptor that plays a key role in T-cell inhibition. Read More

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http://dx.doi.org/10.1007/s00005-019-00548-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732130PMC
October 2019
10 Reads

Variant and Specific Forms of Autoimmune Cholestatic Liver Diseases.

Arch Immunol Ther Exp (Warsz) 2019 Aug 5;67(4):197-211. Epub 2019 Jun 5.

Institute of Internal Medicine and Hepatology, Larissa, Greece.

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. IgG4-associated sclerosing cholangitis is another distinct immune-mediated cholestatic disorder of unknown aetiology that is frequently associated with autoimmune pancreatitis or other IgG4-related diseases. Although the majority of PBC and PSC patients have a typical presentation, there are common and uncommon important variants or specific subgroups that observed in everyday routine clinical practice. Read More

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http://dx.doi.org/10.1007/s00005-019-00550-9DOI Listing
August 2019
8 Reads

Proportion of Cytotoxic Peripheral Blood Natural Killer Cells and T-Cell Large Granular Lymphocytes in Recurrent Miscarriage and Repeated Implantation Failure: Case-Control Study and Meta-analysis.

Arch Immunol Ther Exp (Warsz) 2019 Aug 30;67(4):225-236. Epub 2019 May 30.

Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Service de Médecine Interne, Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DHU i2B), 75005, Paris, France.

We aimed to compare the proportion of peripheral blood natural killer (NK) cells (CD3CD56) and T-cell large granular lymphocytes (CD8CD57) during preconception in a homogenous group of women with unexplained well-defined recurrent miscarriage (RM) and repeated implantation failure (RIF) vs healthy controls in relation to pregnancy outcomes. This case-control study followed by a literature review and meta-analysis was conducted in three university hospitals. Patients and controls were consecutively recruited from December 2015 to October 2017. Read More

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http://dx.doi.org/10.1007/s00005-019-00546-5DOI Listing
August 2019
10 Reads

Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.

Arch Immunol Ther Exp (Warsz) 2019 Aug 29;67(4):249-261. Epub 2019 May 29.

College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Visfatin is involved in the body's inflammation and immune response. Inflammation could promote, while visfatin may directly or indirectly mitigate the effects of apoptosis and autophagy. Whether visfatin lessens the detrimental effects of lipopolysaccharide (LPS)-induced mouse acute lung injury (ALI) is poorly understood yet. Read More

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http://dx.doi.org/10.1007/s00005-019-00544-7DOI Listing
August 2019
3 Reads

MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases?

Arch Immunol Ther Exp (Warsz) 2019 Aug 28;67(4):213-223. Epub 2019 May 28.

Department of Allergology, Medical University of Gdańsk, Dębinki 7, 80-210, Gdańsk, Poland.

MicroRNAs (miRNAs) are small non-coding RNA molecules that are 18-22 nucleotides long and highly conserved throughout evolution. Currently, they are considered one of the fundamental regulatory mechanisms of genes expression. It has been demonstrated that miRNAs are involved in many biologic processes, such as signal transduction, cell proliferation and differentiation, apoptosis and stress responses. Read More

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http://link.springer.com/10.1007/s00005-019-00547-4
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http://dx.doi.org/10.1007/s00005-019-00547-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597590PMC
August 2019
18 Reads

IgG from Non-atopic Individuals Induces In Vitro IFN-γ and IL-10 Production by Human Intra-thymic γδT Cells: A Comparison with Atopic IgG and IVIg.

Arch Immunol Ther Exp (Warsz) 2019 Aug 13;67(4):263-270. Epub 2019 May 13.

Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 500, 3rd Floor, 05403-000, São Paulo, Brazil.

Matured in the thymus, γδT cells can modulate the development of allergy in humans. The main γδT cell subsets have been described as interleukin (IL)-17A or interferon (IFN)-γ producers, but these cells can also produce other modulatory cytokines, such as IL-4 and IL-10. Here, we aimed to evaluate whether IgG can modulate the profile of cytokine production by γδT cells during their maturation in the thymus and after its migration to peripheral tissues. Read More

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http://dx.doi.org/10.1007/s00005-019-00545-6DOI Listing
August 2019
3 Reads

The Influence of Antidepressants on the Immune System.

Arch Immunol Ther Exp (Warsz) 2019 Jun 29;67(3):143-151. Epub 2019 Apr 29.

Department of Adult Psychiatry, Medical University of Gdańsk, Gdańsk, Poland.

Depression is one of the most frequently diagnosed condition in psychiatry. Despite the availability of many preparations, over 30% of treated patients do not achieve remission. Recently the emphasis is put on the contribution of the body's inflammatory response as one of the causes of depression. Read More

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http://dx.doi.org/10.1007/s00005-019-00543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509093PMC
June 2019
5 Reads

Conjugation of Meningococcal Lipooligosaccharides Through Their Non-Reducing Terminus Results in Improved Induction a Protective Immune Response.

Arch Immunol Ther Exp (Warsz) 2019 Aug 27;67(4):237-248. Epub 2019 Apr 27.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wrocław, Poland.

The present studies prove that conjugation of meningococcal lipooligosaccharides through their non-reducing terminus conserves their inner epitopes resulting in conjugates potent to induce a protective immune response. Four different oligosaccharides were obtained by specific degradations of the same L7 lipooligosaccharide (L7-LOS), and each was linked to tetanus toxoid by direct reductive amination. Two were truncated oligosaccharides with incomplete inner epitopes and were obtained by mild acid hydrolysis of lipooligosaccharide. Read More

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http://link.springer.com/10.1007/s00005-019-00542-9
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http://dx.doi.org/10.1007/s00005-019-00542-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597602PMC
August 2019
7 Reads

Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function.

Arch Immunol Ther Exp (Warsz) 2019 Jun 26;67(3):171-177. Epub 2019 Apr 26.

Department of Nephrology and Transplantation Medicine, Faculty of Postgraduate Medical Training, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland.

The complement system is one of the crucial pathophysiological mechanisms that directly influence the function of a transplanted kidney. Since the complement pathways' activation potential can be easily determined via their functional activity measurement, we focused on fluctuation in the cascade activity in the early post-transplant period. The aim of the study was to relate the kidney transplantation-induced complement system response to allograft outcome. Read More

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http://dx.doi.org/10.1007/s00005-019-00541-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509066PMC
June 2019
16 Reads

Heterogeneous Mixture of Amniotic Cells is Likely a Better Source of Stem Cells than Adipose Tissue.

Arch Immunol Ther Exp (Warsz) 2019 Jun 16;67(3):189-196. Epub 2019 Apr 16.

Chair and Department of Descriptive and Topographic Anatomy, School of Medicine, Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze Rokitnica, Poland.

Stem cells are increasingly being used in the course of burn treatment. As several different types of stem cells are available for the purposes, it is important to chose the most efficient and the most practicable stem cell type. The aim of this study was to compare the potential of heterogeneous amnion cell mixture with the presently used standard therapy, the adipose tissue-derived stem cells. Read More

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http://dx.doi.org/10.1007/s00005-019-00538-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509077PMC
June 2019
11 Reads
3.176 Impact Factor

Significance and Role of Pattern Recognition Receptors in Malignancy.

Arch Immunol Ther Exp (Warsz) 2019 Jun 11;67(3):133-141. Epub 2019 Apr 11.

Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.

Pattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Read More

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http://dx.doi.org/10.1007/s00005-019-00540-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509067PMC
June 2019
3 Reads

Natural Killer and Natural Killer T Cells in Juvenile Systemic Lupus Erythematosus: Relation to Disease Activity and Progression.

Arch Immunol Ther Exp (Warsz) 2019 Jun 4;67(3):161-169. Epub 2019 Apr 4.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71526, Egypt.

The contribution of innate immune cells, including natural killer (NK) and natural killer T (NKT) cells, in systemic lupus erythematosus (SLE) is still unclear. Herein, we examined the frequency of peripheral NK cells, CD56 and CD56 NK cells, and NKT cells in patients with juvenile SLE and their potential relations to SLE-related clinical and laboratory parameters. The study included 35 SLE children and 20 apparently healthy controls. Read More

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http://dx.doi.org/10.1007/s00005-019-00537-6DOI Listing
June 2019
10 Reads

PD-L1 Ameliorates Murine Acute Graft-Versus-Host Disease by Suppressing Effector But Not Regulatory T Cells Function.

Arch Immunol Ther Exp (Warsz) 2019 Jun 29;67(3):179-187. Epub 2019 Mar 29.

Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

There is increasing evidence that interaction between programmed death 1 (PD-1) and its ligands PD-1 (PD-L1) plays a critical role in the pathology of acute graft-versus-host disease (aGVHD). However, the role of PD-L1 in the development of aGVHD has been controversial in recent mouse studies. In this study, we carried out studies in a murine aGVHD model to clarify the role of PD-L1 in aGVHD pathogenesis. Read More

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http://dx.doi.org/10.1007/s00005-019-00539-4DOI Listing
June 2019
2 Reads

Theaflavin-3, 3'-Digallate Attenuates Rheumatoid Inflammation in Mice Through the Nuclear Factor-κB and MAPK Pathways.

Arch Immunol Ther Exp (Warsz) 2019 Jun 14;67(3):153-160. Epub 2019 Mar 14.

Department of Rheumatic Immunology, Daqing Oilfield General Hospital, No. 9 Zhongkang Road, Daqing, 163000, Heilongjiang, China.

Rheumatoid arthritis (RA) is a common autoimmune disease which impacts a large number of patients worldwide, and new drugs are required for lower the disease burden. Theaflavin-3, 3'-digallate (TFDG) is polyphenol exhibiting inhibition on inflammatory factors. This study aimed to explore the attenuation of TFDG on RA. Read More

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http://dx.doi.org/10.1007/s00005-019-00536-7DOI Listing
June 2019
5 Reads

The Expression of the SLIT-ROBO Family in Adult Patients with Acute Myeloid Leukemia.

Arch Immunol Ther Exp (Warsz) 2019 Apr 28;67(2):109-123. Epub 2019 Feb 28.

Department of Hematology, Medical University, Lodz, Poland.

Introduction: SLIT-ROBO is a ligand-receptor family of neuronal guidance cues that has been involved in pathological and physiological angiogenesis. SLIT-ROBO expression is altered in many tumours. However, no data exist about the role of the whole family in acute myelogenous myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1007/s00005-019-00535-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420492PMC
April 2019
5 Reads

The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study.

Arch Immunol Ther Exp (Warsz) 2019 Apr 18;67(2):125-131. Epub 2019 Jan 18.

1st Chair and Department of Gynecological Oncology and Gynecology, Medical University of Lublin, Staszica 16, 20-081, Lublin, Poland.

The aim of the study was to assess the activity of fucoidan on the uterine sarcomas (MES-SA and ESS-1) and carcinosarcoma cell lines (SK-UT-1 and SK-UT-1B) and its toxicity on the human skin fibroblasts (HSF). Two uterine sarcomas and two carcinosarcoma cell lines were examined, as a control HSF were used. Cell viability was assessed with MTT test, apoptosis with caspase-3 activity and cell cycle by assessment of DNA synthesis. Read More

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http://link.springer.com/10.1007/s00005-019-00534-9
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http://dx.doi.org/10.1007/s00005-019-00534-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420609PMC
April 2019
23 Reads

Correction to: Building the Prestige of Archivum Immunologiae et Therapiae Experimentalis: From a Little Known to an Internationally Recognized Journal.

Arch Immunol Ther Exp (Warsz) 2019 02;67(1):67

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wrocław, Poland.

According to JCR data, updated in October 2018 by Clarivate Analytics. Read More

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http://dx.doi.org/10.1007/s00005-018-0533-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828296PMC
February 2019
4 Reads

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy.

Arch Immunol Ther Exp (Warsz) 2019 Apr 15;67(2):79-88. Epub 2018 Nov 15.

Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regimens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. Read More

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http://link.springer.com/10.1007/s00005-018-0532-8
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http://dx.doi.org/10.1007/s00005-018-0532-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420452PMC
April 2019
28 Reads

Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond.

Arch Immunol Ther Exp (Warsz) 2019 Apr 2;67(2):89-102. Epub 2018 Nov 2.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, Tehran, 14194, Iran.

Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. Read More

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http://dx.doi.org/10.1007/s00005-018-0531-9DOI Listing
April 2019
35 Reads
3.180 Impact Factor