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    4366 results match your criteria Archivum immunologiae et therapiae experimentalis[Journal]

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    Application of Genome Editing Techniques in Immunology.
    Arch Immunol Ther Exp (Warsz) 2018 Jan 17. Epub 2018 Jan 17.
    Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
    The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such receptors, there is also a need for disruption of certain genes in the immune cells to achieve more potent disease-targeted actions, to produce universal chimeric antigen receptor-based therapies or to study the signaling pathways in detail. Read More

    Biomedical Research in Wrocław: A Combined Density-Equalizing Mapping and Scientometric Analysis.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 3;66(1):1-9. Epub 2018 Jan 3.
    Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt, Germany.
    The aim of this study was to assess the evolution of biomedical scientific activities of Wrocław scientists in the post-war time when this field of academics was rebuilt by the works of Ludwik Hirszfeld and colleagues. Using the NewQIS platform and the Web of Science database, novel procedures such as density-equalizing mapping were combined to bibliometric tools to visualize scientific progression. In total, 10,366 biomedical research articles originating from Wrocław were identified. Read More

    Thymus Colonization: Who, How, How Many?
    Arch Immunol Ther Exp (Warsz) 2017 Dec 29. Epub 2017 Dec 29.
    Institute for Molecular Medicine, Goethe University Frankfurt am Main, 60590, Frankfurt am Main, Germany.
    De novo generation of T cells depends on continual colonization of the thymus by bone marrow-derived progenitors. Thymus seeding progenitors (TSPs) constitute a heterogeneous population comprising multipotent and lineage-restricted cell types. Entry into the thymic microenvironment is tightly controlled and recent quantitative studies have revealed that the adult murine thymus only contains approximately 160 niches to accommodate TSPs. Read More

    Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 27. Epub 2017 Dec 27.
    Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
    Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. Read More

    Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 18. Epub 2017 Dec 18.
    Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
    The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated. The aim of this study is to assess the frequencies of CD4+CD25+Foxp3+ (CD4+Tregs) and CD8+CD25+highFoxp3+ (CD8+Tregs) regulatory T lymphocytes in the peripheral blood of children with AR. In fresh whole blood of 60 children with AR and 40 healthy controls, the frequencies of CD4+Tregs and CD8+Tregs were examined by flow cytometry. Read More

    Allergen-Specific T Cells in IgE-Mediated Food Allergy.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 18. Epub 2017 Dec 18.
    Food Allergy and Anaphylaxis Program, Division of Immunology and Allergy, The Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.
    Food allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food allergens. Read More

    NK and NKT-Like Cells in Patients with Recurrent Furunculosis.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 13. Epub 2017 Dec 13.
    Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.
    To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Read More

    Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 12. Epub 2017 Dec 12.
    Department of Trauma and Orthopedics, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, Shandong, People's Republic of China.
    C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. Read More

    Oxidative Stress in Kidney Diseases: The Cause or the Consequence?
    Arch Immunol Ther Exp (Warsz) 2017 Dec 6. Epub 2017 Dec 6.
    Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006, Warsaw, Poland.
    Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. Read More

    The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 5. Epub 2017 Dec 5.
    Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
    Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Read More

    Adaptive Immune Cell Dysregulation and Role in Acute Pancreatitis Disease Progression and Treatment.
    Arch Immunol Ther Exp (Warsz) 2017 Nov 30. Epub 2017 Nov 30.
    Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa.
    Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. Read More

    Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 14. Epub 2017 Oct 14.
    Immunomodulation Group, Navarrabiomed Biomedical Research Center, Navarre Institute for Health Research (IdiSNA), Pamplona, Spain.
    The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main suppressive mechanisms used by these cell subsets in tumor-bearing hosts. Read More

    Are We Right to Consider Mesenchymal Stem Cells to Be a New Perspective for Patients with Juvenile Idiopathic Arthritis?
    Arch Immunol Ther Exp (Warsz) 2017 Oct 13. Epub 2017 Oct 13.
    Department of Pediatric Rheumatology, Medical University of Lodz, Sporna 36/50, 91-738, Lodz, Poland.
    Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. Read More

    Immunotherapy as an Option for Cancer Treatment.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 12. Epub 2017 Oct 12.
    Department of General, Visceral, and Transplantation Surgery, University Hospital of the LMU, Marchioninistr. 15, 81377, Munich, Germany.
    The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the field of cancer immunotherapy. Currently, there is a wide variety of immunotherapeutic approaches and critical improvements are continually being made. Read More

    Correction to: Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.
    Arch Immunol Ther Exp (Warsz) 2017 Dec;65(6):521
    Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
    The original article has been published without acknowledgment section. The acknowledgement section is given below for your reading. Read More

    The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 3. Epub 2017 Oct 3.
    Department of Parasitology, Institute of Zoology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland.
    Helminths use various immunomodulatory and anti-inflammatory strategies to evade immune attack by the host. During pathological conditions, these strategies alter the course of disease by reducing immune-mediated pathology. The study examines the therapeutic effect of the nematode L4 stage based on an in vivo model of multiple sclerosis, monophasic encephalomyelitis (EAE), induced by sensitization with MOG35-55 peptide in C57BL/6 female mice infected with the intestinal nematode Heligmosomoides polygyrus. Read More

    Biological and Pro-Angiogenic Properties of Genetically Modified Human Primary Myoblasts Overexpressing Placental Growth Factor in In Vitro and In Vivo Studies.
    Arch Immunol Ther Exp (Warsz) 2017 Sep 26. Epub 2017 Sep 26.
    Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
    Cardiovascular diseases are a growing problem in developing countries; therefore, there is an ongoing intensive search for new approaches to treat these disorders. Currently, cellular therapies are focused on healing the damaged heart by implanting stem cells modified with pro-angiogenic factors. This approach ensures that the introduced cells are capable of fulfilling the complex requirements of the environment, including the replacement of the post-infarction scar with cells that are able to contract and promote the formation of new blood vessels that can supply the ischaemic region with nutrients and oxygen. Read More

    Novel Therapeutic Approaches to Atopic Dermatitis.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 31. Epub 2017 Aug 31.
    Department of Pediatric Respiratory Diseases and Allergy, Medical University of Warsaw, Żwirki i Wigury 63A, 02-091, Warsaw, Poland.
    Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. The number of people affected by AD is relatively high and seems to be rising. Although mild and moderate forms of the disease can be well controlled by the use of emollients, topical corticosteroids, and topical calcineurin inhibitors, treatment of severe is still a huge challenge. Read More

    Natural Agents-Mediated Targeting of Histone Deacetylases.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 30;66(1):31-44. Epub 2017 Aug 30.
    Clinical Oncology Department, Alexandria University, Alexandria, Egypt.
    In the past few years, basic and clinical scientists have witnessed landmark achievements in many research projects, such as those conducted by the US National Institutes of Health Roadmap Epigenomics Mapping Consortium, the International Human Epigenome Consortium, The Cancer Genome Atlas Network and the International Cancer Genome Consortium, which have provided near-complete resolution of epigenetic landscape in different diseases. Furthermore, genome sequencing of tumors has provided compelling evidence related to frequent existence of mutations in readers, erasers and writers of epigenome in different cancers. Histone acetylation is an intricate mechanism modulated by two opposing sets of enzymes and deeply studied as a key biological phenomenon in 1964 by Vincent Allfrey and colleagues. Read More

    Comparative Assessment of Induced Immune Responses Following Intramuscular Immunization with Fusion and Cocktail of LeIF, LACK and TSA Genes Against Cutaneous Leishmaniasis in BALB/c Mice.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 4;66(1):55-64. Epub 2017 Aug 4.
    Department of Parasitology and Entomology, Faculty of Medical Sciences, Tarbiat Modares University, P. O. Box 14115-331, Tehran, Iran.
    In the present study, we evaluated induced immune responses following DNA vaccine containing cocktail or fusion of LeIF, LACK and TSA genes or each gene alone. Mice were injected with 100 µg of each plasmid containing the gene of insert, plasmid DNA alone as the first control group or phosphate buffer saline as the second control group. Then, cellular and humoral responses, lesion size were measured for all groups. Read More

    The PD-1/PD-L1 Inhibitory Pathway is Altered in Primary Glomerulonephritides.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 2. Epub 2017 Aug 2.
    Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital in Lublin, Lublin, Poland.
    The pathogenesis of primary proliferative and non-proliferative glomerulonephritides (PGN and NPGN) is still not fully understood, however, current evidence suggests that most cases of PGN and NPGN are the results of immunologic response to different etiologic agents that activates various biological processes leading to glomerular inflammation and injury. Programmed cell death protein 1 (PD-1) is the major inhibitory receptor regulating T cell exhaustion. The aim of this study was to evaluate the frequencies of PD-1-positive and PD-ligand 1 (PD-L1)-positive T and B lymphocytes in patients with NPGN and PGN in relation to clinical parameters for the first time. Read More

    STING Signaling in Cancer Cells: Important or Not?
    Arch Immunol Ther Exp (Warsz) 2017 Jul 26. Epub 2017 Jul 26.
    Laboratory of Experimental Medicine, Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
    Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. Read More

    Role of TGF-β in Self-Peptide Regulation of Autoimmunity.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 21;66(1):11-19. Epub 2017 Jul 21.
    Department of Microbiology & Immunology, Centre for Human Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.
    Transforming growth factor (TGF)-β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide epitopes that downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese diabetic (NOD) mice. These include multiple peptide epitopes derived from the islet β-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin B-chain (Ins. Read More

    Possible Immunomodulating Effect of Retinol on Cytokines Secretion in Patients with Recurrent Furunculosis.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 20;66(1):73-79. Epub 2017 Jul 20.
    Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.
    Recurrent furunculosis is an infection of hair follicles which results in formation of abscesses. Previous studies showed that the pathogenesis of the disease may include an immune-mediated component as the proliferative response of peripheral blood lymphocytes to staphylococcal antigen is depressed. The aim of our study was to evaluate cytokines concentration in the plasma of patients with recurrent furunculosis and to determine whether retinol affects the secretion of those cytokines in patients with recurrent furunculosis and healthy subjects. Read More

    Tumor-Associated Macrophages as Target for Antitumor Therapy.
    Arch Immunol Ther Exp (Warsz) 2017 Jun 28. Epub 2017 Jun 28.
    Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland.
    It is well known that the microenvironment of solid tumors is rich in inflammatory cells that influence tumor growth and development. Macrophages, called tumor-associated macrophages (TAMs), are the most abundant immune cell population present in tumor tissue. Several studies have demonstrated that the density of TAMs is associated with a poor prognosis and positively correlates with tumor growth. Read More

    Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response Against B16 Melanoma.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 21;65(6):553-564. Epub 2017 Jun 21.
    Department of Tumor Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114, Wrocław, Poland.
    Crosslinking of glucocorticoid-induced TNF family-related receptor (GITR) with agonist antibodies restores cancer immunity by enhancing effector T cell (Teff) responses while interfering with intra-tumor regulatory T cell (Treg) stability and/or accumulation. However, how anti-GITR antibody infusion changes T cell receptor (TCR) repertoire of Teffs and Tregs engaged in anti-tumor immune response is unclear. Here, we used a transgenic mouse model (TCRmini) where T cells express naturally generated but limited TCR repertoire to trace the fate of individual T cells recognizing B16 melanoma in tumor-bearing mice, treated or non-treated with an anti-GITR monoclonal antibody DTA-1. Read More

    Skin Immunity.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 16;66(1):45-54. Epub 2017 Jun 16.
    Faculty of Health Science, Wroclaw Medical University, Wrocław, Poland.
    Skin is the largest organ of the body with a complex network of multitude of cell types that perform plastic and dynamic cellular communication to maintain several vital processes such as inflammation, immune response including induction of tolerance and disease prevention, wound healing, and angiogenesis. Of paramount importance are immunological functions of the skin that protect from harmful exposure coming from external and internal environments. Awareness of skin immunity can provide a better comprehension of inflammation, autoimmunity, cancer, graft-versus-host disease, vaccination, and immunotherapy approaches. Read More

    Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 7;65(6):477-499. Epub 2017 Jun 7.
    Section of Human Anatomy and Histology, Laboratory of Cell Biology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 1, 70124, Bari, Italy.
    Amphiregulin (AREG) is a well-characterized member of the epidermal growth factor (EGF) family and is one of the ligands of the EGF receptor (EGFR). AREG plays a key role in mammalian development and in the control of branching morphogenesis in various organs. Furthermore, AREG participates in a wide range of physiological and pathological processes activating the major intracellular signalling cascades governing cell survival, proliferation and motility. Read More

    The Immune Response in Periodontal Tissues.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 6;65(5):421-429. Epub 2017 Jun 6.
    Department of Periodontology and Oral Diseases, Medical University of Warsaw, Miodowa 18, Warsaw, 00-246, Poland.
    The uniqueness of periodontal diseases is caused by several factors. This group of diseases is caused by numerous bacterial species formed in the dental biofilm, and one cannot distinguish the specific pathogen that is responsible for the disease initiation or progress (though Gram-negative anaerobic rods are associated with the advanced form of the disease). The disease is both infectious and inflammatory in its nature, and in the state of health there is always a subclinical level of inflammatory response, caused by the so-called harmless bacteria. Read More

    Heterogeneity Among Neutrophils.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 30;66(1):21-30. Epub 2017 May 30.
    Department of Immunology, Medical University of Bialystok, J. Waszyngtona 15A, 15-269, Białystok, Poland.
    Neutrophils (PMNs) play a key role in innate defence mechanisms. Generally, PMNs were considered to have a homogeneous population of mature and diversified cells. It seems, however, that their pleiotropic action results from the existence of different subpopulations in this group of cells. Read More

    Interleukin (IL)-23 Receptor, IL-17A and IL-17F Gene Polymorphisms in Brazilian Patients with Rheumatoid Arthritis.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 25;65(6):537-543. Epub 2017 May 25.
    Departamento de Biologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, CEP 52171-900, Brazil.
    Rheumatoid arthritis (RA) is a progressive, autoimmune disease for which the previous studies have shown that some functional polymorphisms can influence its etiology. Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), -197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population. A total of 127 RA patients and 134 healthy controls were recruited for the analyses of polymorphic variants. Read More

    Ficolin-2 Gene rs7851696 Polymorphism is Associated with Delayed Graft Function and Acute Rejection in Kidney Allograft Recipients.
    Arch Immunol Ther Exp (Warsz) 2018 Feb 23;66(1):65-72. Epub 2017 May 23.
    Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
    Ficolin-2 is an activator of the complement system that acts via the lectin pathway. Complement activation plays a substantial role in the renal injury inherent to kidney transplantation. In this study, we examined the associations between ficolin-2 gene polymorphisms in exon 8 and kidney allograft function. Read More

    KIR, LILRB and their Ligands' Genes as Potential Biomarkers in Recurrent Implantation Failure.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 18;65(5):391-399. Epub 2017 May 18.
    Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wrocław, Poland.
    Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Read More

    The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 18;65(5):381-389. Epub 2017 May 18.
    Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
    Gli-similar 3 (Glis3) belongs to a Glis subfamily of Krüppel-like zinc-finger transcription factors characterized to regulate a set of downstream targets essential for cellular functions, including pancreatic development, β-cell maturation and maintenance, and insulin production. Examination of the DNA-binding domain of Glis3 reveals that this domain contains a repeated cysteine 2/histidine 2 (Cys2/His2) zinc-finger motif in the central region where the recognized DNA sequence binds. The loss of the production of pancreatic hormones, such as insulin 1 and 2, is linked to the down-regulation of β cells-related genes and promotes the apoptotic death of β cells found in mutant Glis3. Read More

    Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 5;65(6):501-520. Epub 2017 May 5.
    Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
    Immunosuppressive activity of regulatory T and B cells is critical to limit autoimmunity, excessive inflammation, and pathological immune response to conventional antigens or allergens. Both types of regulatory cells are intensively investigated, however, their development and mechanisms of action are still not completely understood. Both T and B regulatory cells represent highly differentiated populations in terms of phenotypes and origin, however, they use similar mechanisms of action. Read More

    Expanding Diversity and Common Goal of Regulatory T and B Cells. II: In Allergy, Malignancy, and Transplantation.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 3;65(6):523-535. Epub 2017 May 3.
    Department Pneumonology, Medical University of Warsaw, Warsaw, Poland.
    Regulation of immune response was found to play an important role in the course of many diseases such as autoimmune diseases, allergy, malignancy, organ transplantation. The studies on immune regulation focus on the role of regulatory cells (Tregs, Bregs, regulatory myeloid cells) in these disorders. The number and function of Tregs may serve as a marker of disease activity. Read More

    CD1: A Singed Cat of the Three Antigen Presentation Systems.
    Arch Immunol Ther Exp (Warsz) 2017 Jun 6;65(3):201-214. Epub 2017 Apr 6.
    Laboratory of Glycoconjugate Immunochemistry, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
    Contrary to general view that the MHC Class I and II are the kapellmeisters of recognition and response to antigens, there is another big player in that part of immunity, represented by CD1 glycoproteins. In contrast to MHC Class I or II, which present peptides, CD1 molecules present lipids. Humans express five CD1 proteins (CD1a-e), four of which (CD1a-d) are trafficked to the cell surface, where they may display lipid antigens to T-cell receptors. Read More

    Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 6;65(6):545-552. Epub 2017 Apr 6.
    ENT Department, School of Medicine, Medical University of Silesia in Katowice, Katowice, Poland.
    The human gyrovirus-Apoptin (HGyv-Apoptin) is a protein that gained attention because it is selectively cytotoxic toward cancer cells. In this study, we have investigated the effect of HGyv-Apoptin on cell cycle progression of cancer cells. We also compared HGyv-Apoptin's action to its homologue chicken anemia virus Apoptin (CAV-Apoptin). Read More

    Evaluation of Endothelial Function by Flow-Mediated Dilation: a Comprehensive Review in Rheumatic Disease.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 30;65(6):463-475. Epub 2017 Mar 30.
    University of Milan, Milan, Italy.
    Flow-mediated dilation (FMD) represents a non-invasive marker of endothelial function to evaluate vascular homeostasis, which reflects the effects of several mechanisms, including vessel tone regulation, cell proliferation, and inflammatory responses. Beyond classical atherosclerotic risk factors such as arterial hypertension, diabetes mellitus, smoking, obesity, and dyslipidemia, chronic inflammation contributes to the endothelial dysfunction causing plaque formation and there is growing evidence of a significantly higher cardiovascular morbidity associated with autoimmune diseases. The endothelium reacts to several endogenous and exogenous stimuli, through surface receptors and intracellular signalling, and releases numerous vasoactive substances, including endothelins, prostacyclins, and nitric oxide (NO). Read More

    Tumor-Associated Macrophages and Regulatory T Cells Infiltration and the Clinical Outcome in Colorectal Cancer.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 25;65(5):445-454. Epub 2017 Mar 25.
    Department of Internal Medicine, Medical University of Silesia in Katowice, Żeromskiego 7, 41-902, Bytom, Poland.
    The aim of the study is the assessment of the intensity of the infiltration of tumor-associated macrophages (TAMs) CD68+/iNOS- and Tregs CD8+/FoxP3+ in colorectal cancer (CRC) patients as prognostic factors with respect to disease-free survival (DFS) and overall survival (OS). In this retrospective study, tissue samples were obtained from 89 patients undergoing resection for CRC (stage IIA, pT3N0M0 and stages IIIB and IIIC, pT3N1-2M0). Recurrence was observed in 45 patients at the time of the follow-up (10 local recurrences, 35 distant metastases). Read More

    The transplantation of mesenchymal stem cells derived from unconventional sources: an innovative approach to multiple sclerosis therapy.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 25;65(5):363-379. Epub 2017 Mar 25.
    Department of Experimental Neurology Laboratory, IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124, Messina, Italy.
    In recent years, in the effort to find a potential innovative therapy for multiple sclerosis (MS), researchers focused on transplantation of mesenchymal stem cells (MSCs) due to their well-recognized ability to suppress inflammatory/autoimmune responses and exert neuroregenerative properties. MSCs are a heterogeneous subset of pluripotent non-hematopoietic stromal cells that can be isolated from many different adult tissues, characterized by the capability to differentiate into various cell lineages, and to translocate into damaged areas, providing immunomodulatory effects. To date, several encouraging results were obtained mainly from the use of MSCs derived from the bone marrow (BM-MSCs) in experimental models of MS as well as in clinical trials. Read More

    Acute Thymic Involution and Mechanisms for Recovery.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 22;65(5):401-420. Epub 2017 Mar 22.
    Department of Basic Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, Hubei, China.
    Acute thymic involution (ATI) is usually regarded as a virulence trait. It is caused by several infectious agents (bacteria, viruses, parasites, fungi) and other factors, including stress, pregnancy, malnutrition and chemotherapy. However, the complex mechanisms that operate during ATI differ substantially from each other depending on the causative agent. Read More

    Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 17;65(4):285-297. Epub 2017 Mar 17.
    Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, 24020-141, Brazil.
    Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER) stress-induced cytotoxicity, and antioxidant activity owing to their activity as free radical scavengers, inhibition of coenzyme Q synthesis, activation of antioxidant-responsive elements (inducing detoxification enzymes) and induction of apoptosis. Activation of ER-stress responses generates reactive oxygen species (ROS), which are highly reactive free radicals mainly produced during mitochondrial electron transfer for adenosine triphosphate (ATP) synthesis. When cells are subjected to oxidative stress conditions, there is an accumulation of ROS that can lead to irreversible cell injury caused primarily by lipid peroxidation, protein aggregation and/or DNA damage. Read More

    Effects of IFN-β1a and IFN-β1b treatment on the expression of cytokines, inducible NOS (NOS type II), and myelin proteins in animal model of multiple sclerosis.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 15;65(4):325-338. Epub 2017 Mar 15.
    Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
    The aim of this study was to investigate the effects of interferon (IFN)-β1a and IFN-β1b treatment on inflammatory factors and myelin protein levels in the brain cortex of the Lewis rat experimental autoimmune encephalomyelitis (EAE), animal model of multiple sclerosis. To induce EAE, rat were immunized with inoculums containing spinal cord guinea pig homogenized in phosphate-buffered saline and emulsified in Freund's complete adjuvant containing 110 µg of the appropriate antigen in 100 µl of an emulsion and additionally 4-mg/ml Mycobacterium tuberculosis (H37Ra). The rats were treated three times per week with subcutaneous applications of 300,000 units IFN-β1a or IFN-β1b. Read More

    Pre-Pregnancy Levels of Peripheral Natural Killer Cells as Markers for Immunomodulatory Treatment in Patients with Recurrent Miscarriage.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 11;65(4):339-346. Epub 2017 Mar 11.
    Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
    Immunological risk factors in patients with recurrent miscarriage (RM) are discussed controversially. Abnormalities of natural killer cells (NK) have been described in RM patients. Lipid infusions are known to modulate lymphocyte subsets. Read More

    Neuronal Differentiation Capability of Nasal Polyps of Chronic Rhinosinusitis.
    Arch Immunol Ther Exp (Warsz) 2017 Oct 9;65(5):431-443. Epub 2017 Mar 9.
    Department of Otorhinolaryngology, University Medical Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
    Chronic rhinosinusitis with nasal polyps is considered a subgroup of chronic rhinosinusitis and a significant health problem, but the pathogenesis remains unclear to date. Therefore, we investigated the stemness to determine the role of stem cells in nasal polyps, with additional analysis of the neuronal differentiation potential of nasal polyp cells. We determined gene and protein expression profiles of stem cells in nasal polyp tissues, using whole genome microarray, quantitative real-time PCR (qPCR), immunohistochemistry, and flow cytometry. Read More

    Sildenafil, a Phosphodiesterase Type 5 Inhibitor, Downregulates Osteopontin in Human Peripheral Blood Mononuclear Cells.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 16;65(4):347-353. Epub 2017 Feb 16.
    Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Poland, Nowogrodzka 59, 02-006, Warsaw, Poland.
    The aim of this study was to investigate the ability of sildenafil to regulate osteopontin (OPN) gene and protein in peripheral blood mononuclear cells (PBMCs) from healthy blood donors. OPN is expressed by a wide variety of cell types, including immune cells. OPN functions are linked to various physiological and pathological conditions. Read More

    The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 15;65(4):355-361. Epub 2017 Feb 15.
    Department of Periodontology, Dental School University of Bern, Bern, Switzerland.
    The rich bacterial flora of oral cavity is controlled by innate immune response, including antibacterial peptides and among them human neutrophil peptides 1-3 (HNP1-3). The knowledge of the involvement of HNPs in innate and acquired immunity of the periodontium is fragmentary. The aim of the study was to assess alterations in HNP1-3 levels in the gingival crevicular fluid (GCF) of chronic periodontitis patients before and after nonsurgical periodontal therapy. Read More

    Identification of Clinicopathological Spectrum, Platelet Glycoprotein IIb/IIIa complex and Platelet Antibodies in Egyptian Children with Glanzmann's Thrombasthenia.
    Arch Immunol Ther Exp (Warsz) 2017 Dec 4;65(6):565-571. Epub 2017 Feb 4.
    Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
    Glanzmann's thrombasthenia (GT) is a rare genetic bleeding disorder. The aim of our study was to evaluate the clinicopathological spectrum of this syndrome and to study the platelet glycoprotein IIb/IIIa complex and platelet antibodies by flow cytometry in a cohort of children with GT in a tertiary care center in Upper Egypt. Forty children with GT were assessed for the expression of GPIIb-IIIa on the platelet surface and platelet antibodies by using flow cytometry, to determine the most common GT subtypes among Egyptian children. Read More

    Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature.
    Arch Immunol Ther Exp (Warsz) 2017 Aug 25;65(4):299-309. Epub 2017 Jan 25.
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona, Bellinzona, Switzerland.
    Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease. It is often associated with extrahepatic autoimmune diseases. Skin disorders are sporadically reported in association with PBC. Read More

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