Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives.
- Maria Ibáñez-Vea,
- Miren Zuazo,
- Maria Gato,
- Hugo Arasanz,
- Gonzalo Fernández-Hinojal,
- David Escors,
- Grazyna Kochan
Arch Immunol Ther Exp (Warsz) 2017 Oct 14. Epub 2017 Oct 14.
Immunomodulation Group, Navarrabiomed Biomedical Research Center, Navarre Institute for Health Research (IdiSNA), Pamplona, Spain.
The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main suppressive mechanisms used by these cell subsets in tumor-bearing hosts. Read More