4,396 results match your criteria Archivum immunologiae et therapiae experimentalis[Journal]


The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study.

Arch Immunol Ther Exp (Warsz) 2019 Jan 18. Epub 2019 Jan 18.

1st Chair and Department of Gynecological Oncology and Gynecology, Medical University of Lublin, Staszica 16, 20-081, Lublin, Poland.

The aim of the study was to assess the activity of fucoidan on the uterine sarcomas (MES-SA and ESS-1) and carcinosarcoma cell lines (SK-UT-1 and SK-UT-1B) and its toxicity on the human skin fibroblasts (HSF). Two uterine sarcomas and two carcinosarcoma cell lines were examined, as a control HSF were used. Cell viability was assessed with MTT test, apoptosis with caspase-3 activity and cell cycle by assessment of DNA synthesis. Read More

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http://link.springer.com/10.1007/s00005-019-00534-9
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http://dx.doi.org/10.1007/s00005-019-00534-9DOI Listing
January 2019
5 Reads

Correction to: Building the Prestige of Archivum Immunologiae et Therapiae Experimentalis: From a Little Known to an Internationally Recognized Journal.

Arch Immunol Ther Exp (Warsz) 2019 Feb;67(1):67

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wrocław, Poland.

According to JCR data, updated in October 2018 by Clarivate Analytics. Read More

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http://dx.doi.org/10.1007/s00005-018-0533-7DOI Listing
February 2019
1 Read

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy.

Arch Immunol Ther Exp (Warsz) 2018 Nov 15. Epub 2018 Nov 15.

Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regimens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. Read More

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http://link.springer.com/10.1007/s00005-018-0532-8
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http://dx.doi.org/10.1007/s00005-018-0532-8DOI Listing
November 2018
10 Reads

Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond.

Arch Immunol Ther Exp (Warsz) 2018 Nov 2. Epub 2018 Nov 2.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, Tehran, 14194, Iran.

Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. Read More

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http://dx.doi.org/10.1007/s00005-018-0531-9DOI Listing
November 2018
14 Reads
3.180 Impact Factor

Characterization of Regulatory T Cells in Preterm and Term Infants.

Arch Immunol Ther Exp (Warsz) 2019 Feb 29;67(1):49-54. Epub 2018 Oct 29.

Department of Medical Biochemistry, School of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.

Our study aimed to study regulatory T cells (Tregs) and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. In an observational study, we used a three-color flow cytometry for determination of Tregs and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. The percentages of CD4CD25Foxp3, CD39 Tregs, HLA-DR Tregs and the expression of Foxp3 in CD4CD25Foxp3 Tregs cells were significantly lower in neonates when compared to healthy adult controls. Read More

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http://link.springer.com/10.1007/s00005-018-0530-x
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http://dx.doi.org/10.1007/s00005-018-0530-xDOI Listing
February 2019
16 Reads
3.180 Impact Factor

Building the Prestige of Archivum Immunologiae et Therapiae Experimentalis: From a Little Known to an Internationally Recognized Journal.

Arch Immunol Ther Exp (Warsz) 2018 Dec 16;66(6):407-413. Epub 2018 Oct 16.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wrocław, Poland.

Archivum Immunologiae et Therapiae Experimentalis (AITE) was founded in 1953 by Ludwik Hirszfeld, a world famous Polish physician and scientist in the field of microbiology and immunology. Initially, AITE was published in Polish, but within a few years, it changed to English to increase the range and number of international readers. In its over 65 year history, AITE has had several Editors and a number of Publishers. Read More

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http://link.springer.com/10.1007/s00005-018-0529-3
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http://dx.doi.org/10.1007/s00005-018-0529-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245239PMC
December 2018
5 Reads

Human Microbiome: Composition and Role in Inflammatory Skin Diseases.

Arch Immunol Ther Exp (Warsz) 2019 Feb 9;67(1):1-18. Epub 2018 Oct 9.

Section of Dermatology and Venereology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, NA, Italy.

This review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases. Read More

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http://link.springer.com/10.1007/s00005-018-0528-4
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http://dx.doi.org/10.1007/s00005-018-0528-4DOI Listing
February 2019
11 Reads

Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis.

Arch Immunol Ther Exp (Warsz) 2018 Oct 5. Epub 2018 Oct 5.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Chodzki 4a, 20-093, Lublin, Poland.

Psoriasis is a chronic debilitating skin disease with an estimated prevalence reaching 2% of the worldwide population. Psoriatic disease is driven by a network of complicated reciprocal interactions among innate and adaptive mechanisms of immune system with structural components of the skin. Interleukin (IL)-22 mediates keratinocyte proliferation and epidermal hyperplasia, inhibits terminal differentiation of keratinocytes, and induces the production of antimicrobial proteins. Read More

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http://dx.doi.org/10.1007/s00005-018-0527-5DOI Listing
October 2018
2 Reads

Precision/Personalized Medicine in Allergic Diseases and Asthma.

Arch Immunol Ther Exp (Warsz) 2018 Dec 24;66(6):431-442. Epub 2018 Sep 24.

Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.

Like many other chronic diseases, every allergic patient has different characteristics based on clinical course, treatment responsiveness and disease outcomes, which are associated with the genetic and epigenetic control of molecular mechanisms and environment. This variability necessitates the establishment of patient-tailored and precision approaches in handling allergic disorders. Better understanding of the underlying pathophysiological mechanisms for the development of allergic disorders will provide more rationale strategies based on individual cases in controlling and treating these disorders. Read More

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http://dx.doi.org/10.1007/s00005-018-0526-6DOI Listing
December 2018
17 Reads

Cellular Interactions in the Intestinal Stem Cell Niche.

Arch Immunol Ther Exp (Warsz) 2019 Feb 21;67(1):19-26. Epub 2018 Sep 21.

Chair of Immunology, Jagiellonian University Medical College, Czysta 18, 31-121, Kraków, Poland.

Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Read More

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http://link.springer.com/10.1007/s00005-018-0524-8
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http://dx.doi.org/10.1007/s00005-018-0524-8DOI Listing
February 2019
77 Reads
3.180 Impact Factor

Role of Monocytes in the Pathogenesis of Dengue.

Arch Immunol Ther Exp (Warsz) 2019 Feb 20;67(1):27-40. Epub 2018 Sep 20.

Grupo de Inmunovirología. Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.

Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this feature is not well understood. One of the main target cells for DENV infection is monocytes; these phagocytes can play a dual role, since they are essential to control viremia, but they also participate in the induction of tissue damage during DENV infection. Read More

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http://dx.doi.org/10.1007/s00005-018-0525-7DOI Listing
February 2019
2 Reads

Manipulation of Non-canonical NF-κB Signaling by Non-oncogenic Viruses.

Arch Immunol Ther Exp (Warsz) 2019 Feb 8;67(1):41-48. Epub 2018 Sep 8.

Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Ciszewskiego 8, 02-786, Warsaw, Poland.

Nuclear factor (NF)-κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Read More

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http://link.springer.com/10.1007/s00005-018-0522-x
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http://dx.doi.org/10.1007/s00005-018-0522-xDOI Listing
February 2019
11 Reads

TLR2 Expression on Leukemic B Cells from Patients with Chronic Lymphocytic Leukemia.

Arch Immunol Ther Exp (Warsz) 2019 Feb 8;67(1):55-65. Epub 2018 Sep 8.

Independent Clinical Transplantology Unit, Medical University of Lublin, Lublin, Poland.

Antigenic stimulation is considered as a possible trigger of neoplastic transformation in chronic lymphocytic leukemia (CLL). B-cell receptor plays a key role in the interactions between the microenvironment and leukemic cells; however, an important role has also been attributed to Toll-like receptors (TLRs). It is believed that disorders of TLR expression may play a part in the pathogenesis of CLL. Read More

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http://dx.doi.org/10.1007/s00005-018-0523-9DOI Listing
February 2019
11 Reads

Celiac Disease Autoimmunity.

Arch Immunol Ther Exp (Warsz) 2018 Dec 25;66(6):423-430. Epub 2018 Aug 25.

Department of Experimental Biology, University of Jaén, Jaén, Spain.

Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Read More

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http://dx.doi.org/10.1007/s00005-018-0520-zDOI Listing
December 2018
1 Read
3.180 Impact Factor

Systemic Treatment for Severe Atopic Dermatitis.

Arch Immunol Ther Exp (Warsz) 2018 Aug 22. Epub 2018 Aug 22.

Division of Clinical Immunology and Allergy, University of São Paulo School of Medicine, Artur Ramos 178 ap.211A, Jd. América, São Paulo, SP, CEP: 01454-904, Brazil.

Atopic dermatitis (AD) is a chronic inflammatory, relapsing disease of the skin, characterized by intense pruritus, maculopapular or vesicular erythematous lesions and scaling, sometimes accompanied by oozing, crusts and/or lichenification that has a negative impact on patients' quality of life. Prevalence is higher in children, around 15%, and approximately 5% in adults. Before introducing systemic therapy, it is mandatory to review patients' adherence to the correct use of topical treatments (corticosteroids, calcineurin inhibitors or cresoborole) and/or phototherapy. Read More

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http://link.springer.com/10.1007/s00005-018-0521-y
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http://dx.doi.org/10.1007/s00005-018-0521-yDOI Listing
August 2018
10 Reads

Innate Lymphoid Cells in Inflammatory Bowel Disease.

Arch Immunol Ther Exp (Warsz) 2018 Dec 29;66(6):415-421. Epub 2018 Aug 29.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL, 32610, USA.

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex chronic inflammatory condition of the human gut of unknown causes. Traditionally, dysregulated adaptive immune responses are thought to play a major role; however, accumulating evidence suggests that innate immunity also contributes to this process. Innate lymphoid cells (ILCs) are recently identified important components of innate immunity. Read More

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http://dx.doi.org/10.1007/s00005-018-0519-5DOI Listing
December 2018
5 Reads

Baicalin Attenuates Joint Pain and Muscle Dysfunction by Inhibiting Muscular Oxidative Stress in an Experimental Osteoarthritis Rat Model.

Arch Immunol Ther Exp (Warsz) 2018 Dec 3;66(6):453-461. Epub 2018 Aug 3.

Department of Sports Injury and Arthroscopy, Tianjin Hospital, Tianjin, 300222, People's Republic of China.

Osteoarthritis (OA) is the most common degenerative joint disease, and causes major pain and disability in adults. It has been reported that muscle weakness and inflammation contribute to osteoarthritis development and progression. Oxidative stress plays important roles in muscle dysfunction and inflammation in osteomyelitis. Read More

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http://dx.doi.org/10.1007/s00005-018-0518-6DOI Listing
December 2018
3 Reads

Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts.

Arch Immunol Ther Exp (Warsz) 2018 Jul 10. Epub 2018 Jul 10.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center' Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.

Xenotransplantation is an attractive solution to the problem of allograft shortage. However, transplants across discordant species barriers are subject to vigorous immunologic and pathobiologic hurdles, some of which might be overcome with the induction of immunologic tolerance. Several strategies have been designed to induce tolerance to a xenograft at both the central (including induction of mixed chimerism and thymic transplantation) and peripheral (including adoptive transfer of regulatory cells and blocking T cell costimulation) levels. Read More

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http://link.springer.com/10.1007/s00005-018-0517-7
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http://dx.doi.org/10.1007/s00005-018-0517-7DOI Listing
July 2018
19 Reads

Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis.

Arch Immunol Ther Exp (Warsz) 2018 Oct 27;66(5):365-377. Epub 2018 Jun 27.

Section for Molecular and Cellular Pharmacology, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. Read More

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http://link.springer.com/10.1007/s00005-018-0516-8
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http://dx.doi.org/10.1007/s00005-018-0516-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154033PMC
October 2018
12 Reads

Deviations in Peripheral Blood Cell Populations are Associated with the Stage of Primary Biliary Cholangitis and Presence of Itching.

Arch Immunol Ther Exp (Warsz) 2018 Dec 27;66(6):443-452. Epub 2018 Jun 27.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

To evaluate the role of Th17, Treg cells, activated T CD3 and B CD19 lymphocytes in primary biliary cholangitis (PBC) patients. 40 female patients with PBC and 20 healthy donors were enrolled in this study. The percentages and absolute counts of Th17, Treg, activated T CD3, B CD19, NK, NKT-like lymphocytes were measured by flow cytometry. Read More

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http://dx.doi.org/10.1007/s00005-018-0515-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245241PMC
December 2018
18 Reads

Differences in the Expression of TLR-2, NOD2, and NF-κB in Placenta Between Twins.

Arch Immunol Ther Exp (Warsz) 2018 Dec 23;66(6):463-470. Epub 2018 May 23.

Chair and Department of Oncologic Pathology and Prophylactics, Greater Poland Cancer Center, Poznań University of Medical Sciences and Department of Oncologic Pathology, Poznan, Poland.

Dizygotic twins share the same type of genetic relationship as non-twin siblings. Whereas monozygotic (MZ) twins are considered to have identical genetic material, they still differ. There is a number of reasons for early MZ twin discordance, including differences in the in utero environment, stochasticity, genetic mosaicism, and epigenetic factors. Read More

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http://dx.doi.org/10.1007/s00005-018-0514-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245244PMC
December 2018
8 Reads
3.180 Impact Factor

Changes in MiRNA-5196 Expression as a Potential Biomarker of Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis Patients.

Arch Immunol Ther Exp (Warsz) 2018 May 9. Epub 2018 May 9.

Department of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.

In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Read More

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http://link.springer.com/10.1007/s00005-018-0513-y
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http://dx.doi.org/10.1007/s00005-018-0513-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154007PMC
May 2018
14 Reads

Detection of 16α-Hydroxyestrone-histone 1 Adduct as High-Affinity Antigen for Rheumatoid Arthritis Autoantibodies.

Arch Immunol Ther Exp (Warsz) 2018 Oct 30;66(5):379-388. Epub 2018 Apr 30.

Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Kingdom of Saudi Arabia.

Increased concentrations of 16α-hydroxyestrone (16α-OHE) have been observed in rheumatoid arthritis (RA), but the underlying mechanism of this remains elusive. Here we aimed to identify the role played by 16α-OHE in RA. In 40 RA patients, the specificities of antibodies from the sera of these patients were checked by direct binding, inhibition ELISA, and quantitative precipitation titration. Read More

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http://dx.doi.org/10.1007/s00005-018-0512-zDOI Listing
October 2018
10 Reads
3.180 Impact Factor

Role of Chicoric Acid and 13-Cis Retinoic Acid in Mycobacterium tuberculosis Infection Control by Human U937 Macrophage.

Arch Immunol Ther Exp (Warsz) 2018 Oct 27;66(5):399-406. Epub 2018 Apr 27.

Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Mycobacterium tuberculosis (Mtb) survives and proliferates within the main cells of the innate immune system, macrophages. The goal of our study was to investigate the immunostimulatory effects of 13-cis retinoic acid (RA) and chicoric acid (CA) in human U937 macrophages against H37Ra Mtb infection by evaluating its potential role in the cell surface expression of HLA-DR, CD14 molecules as well as nitric oxide (NO) production and prevention of the Mtb growth within macrophages. In this study, we investigated the effects of 13-cis RA and CA on Mtb-infected macrophages using flowcytometry and Griess methods, respectively. Read More

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http://link.springer.com/10.1007/s00005-018-0511-0
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http://dx.doi.org/10.1007/s00005-018-0511-0DOI Listing
October 2018
19 Reads

The Microbial Endocrinology of Pseudomonas aeruginosa: Inflammatory and Immune Perspectives.

Arch Immunol Ther Exp (Warsz) 2018 Oct 14;66(5):329-339. Epub 2018 Mar 14.

Translational Respiratory Research Laboratory, Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Level 12, Clinical Sciences Building, Singapore, 308232, Singapore.

Pseudomonas aeruginosa is a major pathogen responsible for both acute and chronic infection. Known as a colonising pathogen of the cystic fibrosis (CF) lung, it is implicated in other settings such as bronchiectasis. It has the ability to cause acute disseminated or localised infection particularly in the immunocompromised. Read More

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http://dx.doi.org/10.1007/s00005-018-0510-1DOI Listing
October 2018
7 Reads

Muscle Stem/Progenitor Cells and Mesenchymal Stem Cells of Bone Marrow Origin for Skeletal Muscle Regeneration in Muscular Dystrophies.

Arch Immunol Ther Exp (Warsz) 2018 Oct 13;66(5):341-354. Epub 2018 Mar 13.

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Muscular dystrophies represent a group of diseases which may develop in several forms, and severity of the disease is usually associated with gene mutations. In skeletal muscle regeneration and in muscular dystrophies, both innate and adaptive immune responses are involved. The regenerative potential of mesenchymal stem/stromal cells (MSCs) of bone marrow origin was confirmed by the ability to differentiate into diverse tissues and by their immunomodulatory and anti-inflammatory properties by secretion of a variety of growth factors and anti-inflammatory cytokines. Read More

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http://dx.doi.org/10.1007/s00005-018-0509-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154032PMC
October 2018
22 Reads

Intestinal Barrier Impairment and Immune Activation in HIV-Infected Advanced Late Presenters are Not Dependent on CD4 Recovery.

Arch Immunol Ther Exp (Warsz) 2018 Aug 21;66(4):321-327. Epub 2018 Feb 21.

Department of Infectious Diseases and Hepatology, Medical University of Lodz, Kniaziewicza 1/5, 91-347, Lodz, Poland.

Damage of the mucosal barrier in HIV infection, microbial translocation, and immune activation can persist even in patients on successful antiretroviral therapy (ART) especially advanced late presenters. The aim of this study was to find factors that determine immune activation and bacterial translocation in HIV-infected advanced late presenters on suppressive ART. Forty-three late presenters (CD4 < 200 cells/µl prior to ART) on successful ART (more than 2 years of ART) with optimal and suboptimal CD4 recovery were enrolled into this study. Read More

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http://dx.doi.org/10.1007/s00005-018-0508-8DOI Listing
August 2018
9 Reads

Adverse Effects Associated with Clinical Applications of CAR Engineered T Cells.

Arch Immunol Ther Exp (Warsz) 2018 Aug 9;66(4):283-288. Epub 2018 Feb 9.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 170, New York, NY, 10065, USA.

Cancer has been ranked as the second leading cause of death in the United States. To reduce cancer mortality, immunotherapy is gaining momentum among other therapeutic modalities, due to its impressive results in clinical trials. The genetically engineered T cells expressing chimeric antigen receptors (CARs) are emerging as a new approach in cancer immunotherapy, with the most successful outcomes in the refractory/relapse hematologic malignancies. Read More

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http://dx.doi.org/10.1007/s00005-018-0507-9DOI Listing
August 2018
10 Reads

Humanized Mice as Unique Tools for Human-Specific Studies.

Arch Immunol Ther Exp (Warsz) 2018 Aug 7;66(4):245-266. Epub 2018 Feb 7.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore.

With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Read More

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http://dx.doi.org/10.1007/s00005-018-0506-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061174PMC
August 2018
21 Reads
1 Citation
3.180 Impact Factor

The Phenomenon of Neutrophil Extracellular Traps in Vascular Diseases.

Arch Immunol Ther Exp (Warsz) 2018 Aug 5;66(4):273-281. Epub 2018 Feb 5.

Department of Immunology, Medical University of Bialystok, J. Waszyngtona 15A, 15-269, Bialystok, Poland.

Vascular diseases constitute a global health issue due to the increasing number of cases of patients with these diseases. The pathogenesis of the majority of these diseases, including atherosclerosis and thrombosis, is complex and not yet fully understood. One of the major causes for their occurrence can be immune disorders resulting in the development of a chronic inflammation within the vessels. Read More

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http://dx.doi.org/10.1007/s00005-018-0505-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061175PMC
August 2018
13 Reads

Application of Genome Editing Techniques in Immunology.

Arch Immunol Ther Exp (Warsz) 2018 Aug 17;66(4):289-298. Epub 2018 Jan 17.

Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such receptors, there is also a need for disruption of certain genes in the immune cells to achieve more potent disease-targeted actions, to produce universal chimeric antigen receptor-based therapies or to study the signaling pathways in detail. Read More

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http://dx.doi.org/10.1007/s00005-018-0504-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061149PMC
August 2018
18 Reads

Biomedical Research in Wrocław: A Combined Density-Equalizing Mapping and Scientometric Analysis.

Arch Immunol Ther Exp (Warsz) 2018 Feb 3;66(1):1-9. Epub 2018 Jan 3.

Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt, Germany.

The aim of this study was to assess the evolution of biomedical scientific activities of Wrocław scientists in the post-war time when this field of academics was rebuilt by the works of Ludwik Hirszfeld and colleagues. Using the NewQIS platform and the Web of Science database, novel procedures such as density-equalizing mapping were combined to bibliometric tools to visualize scientific progression. In total, 10,366 biomedical research articles originating from Wrocław were identified. Read More

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http://dx.doi.org/10.1007/s00005-017-0502-6DOI Listing
February 2018
16 Reads

Thymus Colonization: Who, How, How Many?

Authors:
Andreas Krueger

Arch Immunol Ther Exp (Warsz) 2018 Apr 29;66(2):81-88. Epub 2017 Dec 29.

Institute for Molecular Medicine, Goethe University Frankfurt am Main, 60590, Frankfurt am Main, Germany.

De novo generation of T cells depends on continual colonization of the thymus by bone marrow-derived progenitors. Thymus seeding progenitors (TSPs) constitute a heterogeneous population comprising multipotent and lineage-restricted cell types. Entry into the thymic microenvironment is tightly controlled and recent quantitative studies have revealed that the adult murine thymus only contains approximately 160 niches to accommodate TSPs. Read More

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http://dx.doi.org/10.1007/s00005-017-0503-5DOI Listing
April 2018
10 Reads

Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock.

Arch Immunol Ther Exp (Warsz) 2018 Aug 27;66(4):299-306. Epub 2017 Dec 27.

Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.

Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. Read More

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http://dx.doi.org/10.1007/s00005-017-0499-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061141PMC
August 2018
8 Reads
3.180 Impact Factor

Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis.

Arch Immunol Ther Exp (Warsz) 2018 Aug 18;66(4):307-313. Epub 2017 Dec 18.

Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated. The aim of this study is to assess the frequencies of CD4CD25Foxp3 (CD4Tregs) and CD8CD25Foxp3 (CD8Tregs) regulatory T lymphocytes in the peripheral blood of children with AR. In fresh whole blood of 60 children with AR and 40 healthy controls, the frequencies of CD4Tregs and CD8Tregs were examined by flow cytometry. Read More

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http://dx.doi.org/10.1007/s00005-017-0498-yDOI Listing
August 2018
20 Reads
3.180 Impact Factor

Allergen-Specific T Cells in IgE-Mediated Food Allergy.

Arch Immunol Ther Exp (Warsz) 2018 Jun 18;66(3):161-170. Epub 2017 Dec 18.

Food Allergy and Anaphylaxis Program, Division of Immunology and Allergy, The Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.

Food allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4 T cells have a pivotal role in causing and maintaining the allergic response to food allergens. Read More

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http://link.springer.com/10.1007/s00005-017-0501-7
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http://dx.doi.org/10.1007/s00005-017-0501-7DOI Listing
June 2018
56 Reads

NK and NKT-Like Cells in Patients with Recurrent Furunculosis.

Arch Immunol Ther Exp (Warsz) 2018 Aug 13;66(4):315-319. Epub 2017 Dec 13.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Read More

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http://dx.doi.org/10.1007/s00005-017-0500-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061139PMC
August 2018
20 Reads

Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer.

Arch Immunol Ther Exp (Warsz) 2018 Jun 12;66(3):221-229. Epub 2017 Dec 12.

Department of Trauma and Orthopedics, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, Shandong, People's Republic of China.

C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. Read More

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http://dx.doi.org/10.1007/s00005-017-0497-zDOI Listing
June 2018
13 Reads

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Arch Immunol Ther Exp (Warsz) 2018 Jun 6;66(3):211-220. Epub 2017 Dec 6.

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006, Warsaw, Poland.

Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. Read More

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http://dx.doi.org/10.1007/s00005-017-0496-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956016PMC
June 2018
22 Reads

The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression.

Arch Immunol Ther Exp (Warsz) 2018 Jun 5;66(3):183-197. Epub 2017 Dec 5.

Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Read More

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http://dx.doi.org/10.1007/s00005-017-0494-2DOI Listing
June 2018
31 Reads
3.180 Impact Factor

Adaptive Immune Cell Dysregulation and Role in Acute Pancreatitis Disease Progression and Treatment.

Arch Immunol Ther Exp (Warsz) 2018 Jun 30;66(3):199-209. Epub 2017 Nov 30.

Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa.

Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. Read More

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http://dx.doi.org/10.1007/s00005-017-0495-1DOI Listing
June 2018
9 Reads

Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives.

Arch Immunol Ther Exp (Warsz) 2018 Apr 14;66(2):113-123. Epub 2017 Oct 14.

Immunomodulation Group, Navarrabiomed Biomedical Research Center, Navarre Institute for Health Research (IdiSNA), Pamplona, Spain.

The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main suppressive mechanisms used by these cell subsets in tumor-bearing hosts. Read More

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http://dx.doi.org/10.1007/s00005-017-0492-4DOI Listing
April 2018
16 Reads

Are We Right to Consider Mesenchymal Stem Cells to Be a New Perspective for Patients with Juvenile Idiopathic Arthritis?

Arch Immunol Ther Exp (Warsz) 2018 Aug 13;66(4):267-271. Epub 2017 Oct 13.

Department of Pediatric Rheumatology, Medical University of Lodz, Sporna 36/50, 91-738, Lodz, Poland.

Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. Read More

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http://dx.doi.org/10.1007/s00005-017-0493-3DOI Listing
August 2018
22 Reads

Immunotherapy as an Option for Cancer Treatment.

Arch Immunol Ther Exp (Warsz) 2018 Apr 12;66(2):89-96. Epub 2017 Oct 12.

Department of General, Visceral, and Transplantation Surgery, University Hospital of the LMU, Marchioninistr. 15, 81377, Munich, Germany.

The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the field of cancer immunotherapy. Currently, there is a wide variety of immunotherapeutic approaches and critical improvements are continually being made. Read More

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http://dx.doi.org/10.1007/s00005-017-0491-5DOI Listing
April 2018
39 Reads

Correction to: Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.

Arch Immunol Ther Exp (Warsz) 2017 12;65(6):521

Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland.

The original article has been published without acknowledgment section. The acknowledgement section is given below for your reading. Read More

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http://dx.doi.org/10.1007/s00005-017-0490-6DOI Listing
December 2017
20 Reads

The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis.

Arch Immunol Ther Exp (Warsz) 2018 Jun 3;66(3):231-243. Epub 2017 Oct 3.

Department of Parasitology, Institute of Zoology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland.

Helminths use various immunomodulatory and anti-inflammatory strategies to evade immune attack by the host. During pathological conditions, these strategies alter the course of disease by reducing immune-mediated pathology. The study examines the therapeutic effect of the nematode L4 stage based on an in vivo model of multiple sclerosis, monophasic encephalomyelitis (EAE), induced by sensitization with MOG peptide in C57BL/6 female mice infected with the intestinal nematode Heligmosomoides polygyrus. Read More

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http://dx.doi.org/10.1007/s00005-017-0489-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956022PMC
June 2018
22 Reads

Biological and Pro-Angiogenic Properties of Genetically Modified Human Primary Myoblasts Overexpressing Placental Growth Factor in In Vitro and In Vivo Studies.

Arch Immunol Ther Exp (Warsz) 2018 Apr 26;66(2):145-159. Epub 2017 Sep 26.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.

Cardiovascular diseases are a growing problem in developing countries; therefore, there is an ongoing intensive search for new approaches to treat these disorders. Currently, cellular therapies are focused on healing the damaged heart by implanting stem cells modified with pro-angiogenic factors. This approach ensures that the introduced cells are capable of fulfilling the complex requirements of the environment, including the replacement of the post-infarction scar with cells that are able to contract and promote the formation of new blood vessels that can supply the ischaemic region with nutrients and oxygen. Read More

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http://dx.doi.org/10.1007/s00005-017-0486-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851700PMC
April 2018
18 Reads

Novel Therapeutic Approaches to Atopic Dermatitis.

Arch Immunol Ther Exp (Warsz) 2018 Jun 31;66(3):171-181. Epub 2017 Aug 31.

Department of Pediatric Respiratory Diseases and Allergy, Medical University of Warsaw, Żwirki i Wigury 63A, 02-091, Warsaw, Poland.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. The number of people affected by AD is relatively high and seems to be rising. Although mild and moderate forms of the disease can be well controlled by the use of emollients, topical corticosteroids, and topical calcineurin inhibitors, treatment of severe is still a huge challenge. Read More

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http://dx.doi.org/10.1007/s00005-017-0487-1DOI Listing
June 2018
28 Reads

Natural Agents-Mediated Targeting of Histone Deacetylases.

Arch Immunol Ther Exp (Warsz) 2018 Feb 30;66(1):31-44. Epub 2017 Aug 30.

Clinical Oncology Department, Alexandria University, Alexandria, Egypt.

In the past few years, basic and clinical scientists have witnessed landmark achievements in many research projects, such as those conducted by the US National Institutes of Health Roadmap Epigenomics Mapping Consortium, the International Human Epigenome Consortium, The Cancer Genome Atlas Network and the International Cancer Genome Consortium, which have provided near-complete resolution of epigenetic landscape in different diseases. Furthermore, genome sequencing of tumors has provided compelling evidence related to frequent existence of mutations in readers, erasers and writers of epigenome in different cancers. Histone acetylation is an intricate mechanism modulated by two opposing sets of enzymes and deeply studied as a key biological phenomenon in 1964 by Vincent Allfrey and colleagues. Read More

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http://dx.doi.org/10.1007/s00005-017-0488-0DOI Listing
February 2018
90 Reads

Comparative Assessment of Induced Immune Responses Following Intramuscular Immunization with Fusion and Cocktail of LeIF, LACK and TSA Genes Against Cutaneous Leishmaniasis in BALB/c Mice.

Arch Immunol Ther Exp (Warsz) 2018 Feb 4;66(1):55-64. Epub 2017 Aug 4.

Department of Parasitology and Entomology, Faculty of Medical Sciences, Tarbiat Modares University, P. O. Box 14115-331, Tehran, Iran.

In the present study, we evaluated induced immune responses following DNA vaccine containing cocktail or fusion of LeIF, LACK and TSA genes or each gene alone. Mice were injected with 100 µg of each plasmid containing the gene of insert, plasmid DNA alone as the first control group or phosphate buffer saline as the second control group. Then, cellular and humoral responses, lesion size were measured for all groups. Read More

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http://dx.doi.org/10.1007/s00005-017-0484-4DOI Listing
February 2018
14 Reads