1,252 results match your criteria Archives of physiology and biochemistry[Journal]


Exercise training decreases oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension.

Arch Physiol Biochem 2020 May 25:1-9. Epub 2020 May 25.

Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session, at 60% of VO max. Read More

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http://dx.doi.org/10.1080/13813455.2020.1769679DOI Listing

MicroRNA-143 inhibits proliferation and migration of prostate cancer cells.

Arch Physiol Biochem 2020 May 25:1-7. Epub 2020 May 25.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Prostate cancer (PC) is one of the most prevalent types of malignancies in males. Here, we replaced the miRNA-143 in PC cells by using a vector-based miRNA-143 transfection approach. The miRNA-143 vector was transfected into the cells and qRT-PCR was applied to assess the expression of target genes in PC3 cells. Read More

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http://dx.doi.org/10.1080/13813455.2020.1769678DOI Listing

The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF.

Arch Physiol Biochem 2020 May 25:1-10. Epub 2020 May 25.

Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang, China.

Gene expression microarray and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure the expression of miR-126. In model of diabetic nephropathy, we demonstrated that miR-126 expression was down-regulated, compared with control group. Down-expression of miR-126 promoted cell apoptosis and increased inflammation (as indicated by the levels of IL-1β, IL-6, IL-18 and TNF-α) of diabetic nephropathy . Read More

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http://dx.doi.org/10.1080/13813455.2020.1767146DOI Listing

Identification of amyloid antibodies for Alzheimer disease - immunotherapy.

Arch Physiol Biochem 2020 May 25:1-8. Epub 2020 May 25.

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

The current study identified the specific antibodies that recognise amyloid protein for Alzheimer disease - immunotherapy. The immune-selection of random sequences from a phage display library and sequencing to obtain the random 12 amino acids peptide library for each antibody, and then we analysed these peptides for unique and common sequences, relation to Aβ42 sequence and shape and pattern of the amino acid reaction to the antibody to predict the epitopes. Data obtained for 4G8 showed that, the sequence segment related to the putative epitope of 4G8 was LVFFAED. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767147DOI Listing

Determination of carnitine ester profile in the children with type 1 diabetes: a valuable step towards a better management.

Arch Physiol Biochem 2020 May 24:1-6. Epub 2020 May 24.

Growth and Development Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

This study is designed to investigate the levels of carnitine and acylcarnitines (ACs) in the children with diabetes type 1 compared to the healthy subjects. Forty-two type 1 diabetic children and healthy subjects were recruited in the study, respectively. In addition to FBS and Hb A1C, free carnitine and ACs in butyl-ester form in the fasting blood samples were assessed by isotope dilution mass spectrometry for all diabetics and controls using the tandem mass spectrometry system. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762662DOI Listing

Allopurinol and valproic acid improve cardiac triglyceride and Na-K-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance.

Arch Physiol Biochem 2020 May 23:1-7. Epub 2020 May 23.

Department of Physiology, HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

Studies have shown that cardiac triglyceride accumulation and impaired Na-K-ATPase activity are linked to diabetes- related cardiovascular disease, particularly in women. We hypothesised that allopurinol (ALL) and valproic acid (VPA) treatment would improve cardiac triglyceride and Na-K-ATPase activity independent of circulating aldosterone in Combined Oral Contraceptive (COC)-induced dysglycemia Rats received COC (1.0 μg ethinylestradiol and 5. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767148DOI Listing

Variation in the expression level of MALAT1, MIAT and XIST lncRNAs in coronary artery disease patients with and without type 2 diabetes mellitus.

Arch Physiol Biochem 2020 May 23:1-8. Epub 2020 May 23.

Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran.

: The MALAT1, MIAT, and XIST long noncoding RNAs (lncRNAs) participate in the pathogenesis of complex diseases and also serve as diagnostic markers. The study aimed to assess their expressions in CAD patients with or without T2DM against diabetic and non-diabetic controls.: The expression levels of three lncRNAs in 50 CAD patients (with or without diabetes) and 50 non-CAD subjects (with or without diabetes) were evaluated by using the TaqMan Assay method. Read More

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http://dx.doi.org/10.1080/13813455.2020.1768410DOI Listing

An investigation of the relationship between new fasting hormone asprosin, obesity and acute-chronic exercise: current systematic review.

Arch Physiol Biochem 2020 May 19:1-12. Epub 2020 May 19.

Faculty of Sports Sciences, Coaching Science Department, Mugla Sitki Kocman University, Muğla, Turkey.

The purpose of this study was to reveal the relationship between new fasting hormone asprosin, obesity, and acutechronic exercise. The prisma guidelines were followed in forming the methodological model of this review. The articles between 2016 and 2020 (including March) were identified by scanning Google Scholar, Pub Med, and Science Direct databases. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767652DOI Listing

Zaprinast and avanafil increase the vascular endothelial growth factor, vitamin D, bone morphogenic proteins 4 and 7 levels in the kidney tissue of male rats applied the glucocorticoid.

Arch Physiol Biochem 2020 May 18:1-7. Epub 2020 May 18.

Department of Biochemistry, Medical Faculty, Sakarya University, Sakarya, Turkey.

This study investigated effect of zaprinast and avanafil on vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 4 and 7, and vitamin D levels against the negative effect of dexamethazone. Rats were randomly divided into four groups ( = 6). Control: Empty a syringe was immersed and removed subcutaneously. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767149DOI Listing

Circulating microRNA-944 and its target gene EPHA7 as a potential biomarker for colorectal cancer.

Arch Physiol Biochem 2020 May 18:1-7. Epub 2020 May 18.

Department of Biochemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.

MicroRNAs (miRNAs) have critical roles in colorectal cancer (CRC) tumorigenesis and development. It has been reported that Eph receptor A7 (EphA7) was a potential target of miR-944 which is transcriptionally activated in cancer. The aim of this study was to explore the expression profile of miR-944 and its target gene EPHA7 in the serum of Egyptian CRC patients. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762658DOI Listing

A blockade of microRNA-155 signal pathway has a beneficial effect on neural injury after intracerebral haemorrhage via reduction in neuroinflammation and oxidative stress.

Arch Physiol Biochem 2020 May 15:1-7. Epub 2020 May 15.

Department of Anesthesiology, The First Hospital of Jilin University, Changchun, China.

MicroRNAs (miRNAs) have important contributions to multiple pathophysiological processes for cellular response to stress and are considered as promising therapeutic targets with respect to drug development due to their small size, relative ease of delivery, and sequence specificity. Thus, in the current report, we examined the effects of inhibiting miRNA-155 (miR-155) on the levels of pro-inflammatory cytokines (PICs), oxidative stress products as well as vascular endothelial growth factor (VEGF) in the parietal cortex and hippocampus of rats following intracerebral haemorrhage (ICH). Real time PCR was used to examine the levels of miR-155 in the parietal cortex and hippocampus of rats; and ELISA to measure IL-1β, IL-6 and TNF-α, oxidative 8-iso PGF2α and 8-OHdG, and VEGF. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764047DOI Listing

The effect of interval training on adipokine plasmatic levels in rats with induced myocardial infarction.

Arch Physiol Biochem 2020 May 15:1-5. Epub 2020 May 15.

Department of Health and Human Performance, Marymount University, Arlington, VA, USA.

Exercise has been demonstrated to reduce pro-inflammatory while boosting anti-inflammatory adipokines; yet research in relation to Myocardial infarction (MI) is limited. The aim of this study was to investigate the effect of an interval exercise-training programme on concentrations of Lipocalin-2 and Adiponectin plasmatic levels in rats with induced MI. The experimental study design comprised of three groups, including: a control group, MI control group and MI training group that participated in an interval training protocol for six weeks. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764049DOI Listing

Effects of acute endurance exercise on follistatin-like 1 and apelin in the circulation and metabolic organs in rats.

Arch Physiol Biochem 2020 May 15:1-5. Epub 2020 May 15.

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.

Follistatin-like 1 (FSTL1) and apelin exert a favourable effect on energy metabolism. We examined the effects of acute endurance exercise on the levels of FSTL1 and apelin in the serum and metabolic organs of rats. Rats were divided into two groups: a sedentary control (CON,  = 8) group and exercise (EX,  = 8) group. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764050DOI Listing

Alteration of miR-21, miR-433 and miR-590 tissue expression related to the TGF-β signaling pathway in ulcerative colitis patients.

Arch Physiol Biochem 2020 May 15:1-5. Epub 2020 May 15.

Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of medical sciences, Tehran, Iran.

Ulcerative colitis (UC) is an inflammatory disease, and studies have suggested a role for TGF-β signalling pathway in the pathogenesis of UC. In the present study, we evaluated expression of TGF-β signalling genes and their regulatory microRNAs in patients with UC and control subjects. The expression of TGF-β1, SMAD2, SMAD3, miR-21, miR-101, miR-433, and miR-590 were evaluated using real-time PCR in biopsy samples of the patients and controls. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762656DOI Listing

Can miR-145-5p be used as a marker in diabetic patients?

Arch Physiol Biochem 2020 May 15:1-6. Epub 2020 May 15.

Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In the light of emerging global epidemics of type 2 diabetes mellitus significant efforts are continuing to discover novel biomarkers for early detection of the disease. Since miRNAs play an important role in both the initiation and progress of many pathologic processes such as diabetes, in this study we aimed to evaluate expression level of plasma miR-145-5p in diabetics and pre-diabetics in comparison to the control group and assess its use as a biomarker in diagnosis of T2D. The plasma level of miR-145-5p was assessed in three groups including 20 prediabetic patients, 20 T2D patients and 20 healthy controls using RT-qPCR. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762657DOI Listing

Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days.

Arch Physiol Biochem 2020 May 15:1-7. Epub 2020 May 15.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.

Lam. has been used traditionally for the treatment of different cardio-metabolic disorders. So, the aim was to assess its leaf extracts in metabolic syndrome rat model. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762661DOI Listing

The effects of metformin on the hippo pathway in the proliferation of melanoma cancer cells: a preclinical study.

Arch Physiol Biochem 2020 May 14:1-6. Epub 2020 May 14.

Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

YAP and TAZ, two closely related transcriptional regulators, have crucial roles in tissue repair upon injury, organ size control, and cancer treatment. Some drugs, such as metformin, that alter cell metabolism can play a role in the regulation of the Hippo pathway. The cells were treated with various concentrations of metformin, dacarbazine (IC), and both of them. Read More

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http://dx.doi.org/10.1080/13813455.2020.1760304DOI Listing

The synergic effects of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric measurements and the serum levels of VEGF, NO, sirtuin-1, and PGC1-α in obese people undergoing a weight loss diet.

Arch Physiol Biochem 2020 May 14:1-7. Epub 2020 May 14.

Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.

The anti-obesity effects of Alpha-lipoic acid (α-LA) and isotonic contraction has been reported. However, the underlying mechanism is not fully understood. This study aimed to investigate the effect of 1200 mg/day α-LA supplementation and 3 sessions per week of Faradic (an electrical stimulating system) on anthropometric parameters, body composition, VEGF, Sirtuin-1, nitric oxide (NO), and PGC1-α in obese people undergoing a weight loss regime. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762660DOI Listing

-Chalcone inhibits transforming growth factor-β1 and connective tissue growth factor-dependent collagen expression in the heart of high-fat diet-fed rats.

Arch Physiol Biochem 2020 May 14:1-4. Epub 2020 May 14.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Non-alcoholic fatty liver disease (NAFLD) is one of the main risk factors for cardiovascular mortality and morbidity. This study, for the first time, explored the effects of -chalcone on cardiac expressions of myocardial fibrosis-related genes, including transforming growth factor -β1 (TGF-β1), connective tissue growth factor (CTGF/CCN2), and collagen type I. Twenty-eight rats were randomly divided into four groups: control, received 10% tween 80; chalcone, received -chalcone; HFD, received high-fat diet (HFD) and 10% tween 80; HFD + chalcone, received HFD and -chalcone, by once-daily gavage for 6 weeks. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764045DOI Listing

Angiotensin-converting enzyme gene insertion/deletion polymorphism and hypertension disease.

Arch Physiol Biochem 2020 May 13:1-5. Epub 2020 May 13.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

The renin-angiotensin system (RAS), which is important for controlling haemostasis in the body, can increase the development of essential hypertension (HTN). Various surveys have shown that ACE I/D polymorphism that influences ACE activity, a key component of RAS, has been known to be associated with the risk of HTN. The goal of this study was to investigate the correlation between ACE (I/D) polymorphism and HTN. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762225DOI Listing

Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats.

Arch Physiol Biochem 2020 May 13:1-6. Epub 2020 May 13.

Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.

Present study investigated the effect of continued training (CT) and interval training (IT) with crocin (C) supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetes (T2D) rats. Forty-eight high fat diet and streptozotocin- induced diabetic rats (mean age: 20 weeks, mean weight: 360.12 ± 12. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762663DOI Listing

Effects of dexmedetomidine on new oxidative stress markers on renal ischaemia-reperfusion injury in rats: thiol/disulphide homeostasis and the ischaemia-modified albumin.

Arch Physiol Biochem 2020 May 13:1-6. Epub 2020 May 13.

Department of Biochemistry, Sakarya University, Sakarya, Turkey.

This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Read More

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http://dx.doi.org/10.1080/13813455.2020.1754431DOI Listing

Impact of acute inflammation on Band 3 protein anion exchange capability in human erythrocytes.

Arch Physiol Biochem 2020 May 13:1-7. Epub 2020 May 13.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

The impact of acute inflammation, revealed by C-reactive protein (CRP) plasma levels, has been studied on the erythrocytes anion exchanger Band 3 protein. Anion exchange capability through Band 3 protein, lipid peroxidation, -SH membrane groups and intracellular GSH levels have been measured on erythrocytes from patients with CRP >8mg/L. Under acute inflammation, a significant increase in anion exchange capability, increased lipid peroxidation, decreased-SH groups and GSH content were observed. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764048DOI Listing

New insights into the , and antihyperglycemic mechanisms of gallic acid and -coumaric acid.

Arch Physiol Biochem 2020 May 13:1-7. Epub 2020 May 13.

Faculty of Pharmacy, The British University, Cairo, Egypt.

To explore the probable and mechanisms of gallic acid (GA) and -coumaric acid (PCA) as anti-hyperglycemic agents. Male albino rats were allocated into four groups, group1 was used as normal control. Group 2 was established as a diabetic control and group3 and 4 were treated with an oral dose of GA and PCA, respectively. Read More

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http://dx.doi.org/10.1080/13813455.2020.1762659DOI Listing

Baicalein maintains redox balance in experimental hyperlipidemic rats.

Arch Physiol Biochem 2020 May 12:1-9. Epub 2020 May 12.

Department of Biochemistry, University of Allahabad, Allahabad, India.

An altered lipid profile may lead to the development of CVD. We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats. Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0. Read More

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http://dx.doi.org/10.1080/13813455.2020.1760890DOI Listing

Association of calorie and carbohydrate intake with tumour grade in early diagnosis of breast cancer: a case-control study.

Arch Physiol Biochem 2020 May 6:1-4. Epub 2020 May 6.

Department of Basic Sciences and Cellular and Molecular Nutrition, Faculty of Nutrition Sciences and Food Technology and National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study aimed to investigate the association of calorie and carbohydrate intake with tumour grade in early detection of breast cancer (BC) in Iranian women. This case-control study carried out on 62 women with high grade BC and 93 women with low grade BC. Information about confounding variables was collected through a questionnaire. Read More

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http://dx.doi.org/10.1080/13813455.2020.1754430DOI Listing

Comparative study on effect of mesenchymal stem cells and endothelial progenitor cells on treatment of experimental CCL4-induced liver fibrosis.

Arch Physiol Biochem 2020 May 6:1-10. Epub 2020 May 6.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.

We speculated impacts of BM-MSCs and UC-EPCs on reversal of hepatic injury induced by carbon tetrachloride (CCl4). Fifty adult rats were divided into five groups: control group, CCl4A group, CCl4B group, CCl4/BM-MSCs group and CCl4/UC-EPCs group. Blood samples were driven to measure concentration of albumin and ALT. Read More

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http://dx.doi.org/10.1080/13813455.2020.1752256DOI Listing

β-cryptoxanthin alleviates myocardial ischaemia/reperfusion injury by inhibiting NF-κB-mediated inflammatory signalling in rats.

Arch Physiol Biochem 2020 May 2:1-8. Epub 2020 May 2.

TEDA International Cardiovascular Hospital, Tianjin, China.

The present study aimed to explore the function and molecular mechanism of β-cryptoxanthin on myocardial ischaemia-reperfusion injury (MIRI). Left anterior descending coronary artery ligation with reperfusion was utilised to establish a MIRI rat model. The results indicated that β-cryptoxanthin decreases infarct size and ameliorates signs of pathological histology in MIRI. Read More

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http://dx.doi.org/10.1080/13813455.2020.1760302DOI Listing

Bee bread attenuates high fat diet induced renal pathology in obese rats via modulation of oxidative stress, downregulation of NF-kB mediated inflammation and Bax signalling.

Arch Physiol Biochem 2020 Apr 22:1-17. Epub 2020 Apr 22.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Global prevalence of obesity is increasing. To study the effect of bee bread (BB) on serum renal function parameters, oxidative stress, inflammatory and B-cell associated protein X (Bax) in the kidneys of high fat diet (HFD) obese rats. Thirty-six male Sprague Dawley rats were used. Read More

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http://dx.doi.org/10.1080/13813455.2020.1752258DOI Listing

Relevance of circulating MiRNA-21 and MiRNA-181 in prediction of glioblastoma multiforme prognosis.

Arch Physiol Biochem 2020 Apr 21:1-6. Epub 2020 Apr 21.

Biochemistry Department, Genetic Engineering and Biotechnology Research Division, High Throughput Molecular and Genetic laboratory, Center for Excellences for Advanced Sciences, National Research Centre, Giza, Egypt.

Authors aimed to investigate the clinical role of miR-21 and miR-181 among glioblastoma multiforme (GBM) patients. Expression for both miRs were detected in blood samples from newly diagnosed twenty GBM patients before and after treatment along with 20 healthy individuals using QPCR technology. MiR-21 reported increase expression while miR-181 reported decreased expression in GBM patients. Read More

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http://dx.doi.org/10.1080/13813455.2020.1739716DOI Listing

Stimulating effects of vardenafil, tadalafil, and udenafil on vascular endothelial growth factor, angiogenesis, vitamin D, bone morphogenic proteins in ovariectomized rats.

Arch Physiol Biochem 2020 Apr 21:1-7. Epub 2020 Apr 21.

Medical Faculty, Department of Biochemistry, Sakarya University, Sakarya, Turkey.

This study investigated the effect of vardenafil, tadalafil, and udenafil from phosphodiesterase-5 inhibitors (PDE-5Is) on bone morphogenic-protein (BMP)2 and 4 levels, along with angiogenesis in ovariectomized rat's kidney. Rats were randomly divided into five groups ( = 10). Sham: abdomen was opened, and closed. Read More

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http://dx.doi.org/10.1080/13813455.2020.1755695DOI Listing

Effects of aminophylline on the levels of neutrophil gelatinase-associated lipocalin (NGAL) in asphyxiated term neonates.

Arch Physiol Biochem 2020 Apr 17:1-6. Epub 2020 Apr 17.

Department of Pediatrics, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Our study evaluates the effects of aminophylline in the reduction of NGAL levels in perinatal asphyxia. Term neonates with hypoxic ischaemic encephalopathy who were divided into two groups, the treatment and placebo. Urine NGAL levels were measured on day one and four of the treatment using BIOPORTO kits in both the groups. Read More

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http://dx.doi.org/10.1080/13813455.2020.1752259DOI Listing

LncRNA RPSAP52 regulates miR-423-5p/GSTM1 axis to suppress hypoxia-induced renal proximal tubular epithelial cell apoptosis.

Arch Physiol Biochem 2020 Apr 17:1-5. Epub 2020 Apr 17.

Injury Prevention Research Center, Shantou University Medical College, Shantou, P.R. China.

This study aimed to investigate the roles of RPSAP52 in renal failure. Our results showed that RPSAP52 was upregulated in plasma of renal failure patients in comparison to healthy controls. Dual luciferase reporter assay showed that RPSAP52 could interact with miR-423-5p, while overexpression of RPSAP52 and miR-423-5p did not alter the expression of each other in human renal proximal tubular epithelial cells (HRPTEpCs). Read More

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http://dx.doi.org/10.1080/13813455.2020.1750657DOI Listing

PBMCs: a new source of diagnostic and prognostic biomarkers.

Arch Physiol Biochem 2020 Apr 15:1-7. Epub 2020 Apr 15.

Department of Genetics and Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

There are various types of molecular biomarkers that are derived from distinct starting materials. Although many indirect biomarkers are found in blood, their detection remains a challenging issue because of the high degree of fragmentation, minute quantity and a vast amount of non-specific background. The present review points out the sensitivity and specificity of peripheral blood mononuclear cells (PBMCs) as an intact source of biomarkers in a variety of diseases. Read More

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http://dx.doi.org/10.1080/13813455.2020.1752257DOI Listing

Chaperone duality: the role of extracellular and intracellular HSP70 as a biomarker of endothelial dysfunction in the development of atherosclerosis.

Arch Physiol Biochem 2020 Apr 15:1-8. Epub 2020 Apr 15.

Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Ijuí, Brazil.

The 70-kDa heat shock proteins (HSP70) may provide relevant information about the endothelial dysfunction in cardiovascular diseases. Located in the intracellular milieu (iHSP70), they are essential chaperones that inhibit nuclear factor kappa B activation, stimulate nitric oxide production and superoxide dismutase activity, and inhibit apoptosis. However, under stressful conditions, HSP70 can be released into the extracellular medium (eHSP70) and act as an inflammatory mediator. Read More

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http://dx.doi.org/10.1080/13813455.2020.1745850DOI Listing

Clinical role of MiRNA 29a and MiRNA 335 on breast cancer management: their relevance to MMP2 protein level.

Arch Physiol Biochem 2020 Apr 8:1-8. Epub 2020 Apr 8.

Biochemistry Department, Genetic Engineering and Biotechnology Research Division, Giza, Egypt.

Circulating miRNAs are novel biomarkers, authors aimed to investigate the expression level of miR-29a and miR-335 and their relevance to CEA, CA15.3, and matrix metalloproteinase-2 (MMP2). Breast cancer (BC) patients ( = 44), benign breast lesion patients ( = 25), and healthy individuals ( = 19) were enrolled for detection of miRNA expression levels, MMP2 and biochemical markers using quantitative polymerase chain reaction (PCR) and ELISA, respectively. Read More

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http://dx.doi.org/10.1080/13813455.2020.1749085DOI Listing

MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage.

Arch Physiol Biochem 2020 Apr 7:1-8. Epub 2020 Apr 7.

Central of Translation Medicine, Zibo Central Hospital, Shandong University, Zibo, China.

The membrane-bound transcription factor protease site 2 (MBTPS2) is an intramembranous metalloprotease involved in the regulation of ER stress response, however, whether it is associated with DN is unknown. Results: We report that MBTPS2 expression is upregulated in the renal cortex of diabetic mice induced by streptozotocin (STZ), a murine model of insulinopenic type 1 DN. Functionally, in vivo, MBTPS2 overexpression exacerbates and its knockdown attenuates albuminuria, which indicate a detrimental role of MBTPS2 played in albuminuria development in DN mice. Read More

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http://dx.doi.org/10.1080/13813455.2020.1749084DOI Listing

Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation.

Arch Physiol Biochem 2020 Apr 7:1-11. Epub 2020 Apr 7.

Reproductive Physiology and Endocrinology Laboratory, Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, India.

The antiobesity effect of dietary calcium by preventing fat accumulation and weight gain was well established from several epidemiological and animal studies. To evaluate the effect of dietary calcium against obesity-associated with renal injury in high fat diet induced obese rats. Materials and Methods: Obesity was induced by high fat diet (HFD) and then given either low or high calcium HFD (0. Read More

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http://dx.doi.org/10.1080/13813455.2020.1746812DOI Listing

Association between HDACs and pro-inflammatory cytokine gene expressions in obesity.

Arch Physiol Biochem 2020 Apr 2:1-7. Epub 2020 Apr 2.

Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Histone deacetylases (HDACs) are important players in a variety of physiological and pathological conditions. Few studies have addressed HDAC expressions in human adipose tissue in obese individuals, and their association with pro-inflammatory cytokines. Here, we compared 20 non-obese and 20 obese women to investigate possible changes in gene expressions of HDAC2, 4, 5, and 6 in the subcutaneous adipose tissues (SAT) and visceral adipose tissues (VAT) of these individuals. Read More

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http://dx.doi.org/10.1080/13813455.2020.1734843DOI Listing

Vitamin D attenuates endothelial dysfunction in streptozotocin induced diabetic rats by reducing oxidative stress.

Authors:
Mona A Said

Arch Physiol Biochem 2020 Apr 1:1-5. Epub 2020 Apr 1.

Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt.

Diabetes mellitus (DM) is associated with micro- and macrovascular complications and increased cardiovascular risk. Vitamin D deficiency is the most common nutrient deficiency in the world. This study aimed to examine the effects of diabetes on the endothelial function and the role of vitamin D supplementation. Read More

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http://dx.doi.org/10.1080/13813455.2020.1741645DOI Listing

Nutritional interventions for improving the endurance performance in athletes.

Arch Physiol Biochem 2020 Mar 30:1-8. Epub 2020 Mar 30.

Department of Biochemistry, CSIR-CFTRI, Mysuru, India.

Endurance refers to the ability of skeletal muscles to perform continuously withstanding the hardships of exercise. Endurance exercises have three phases: pre-, during-, and post-workout phase. The nutritional requirements that drive these phases vary on intensity, type of workout, individual's body composition, training, weather conditions, etc. Read More

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http://dx.doi.org/10.1080/13813455.2020.1733025DOI Listing

Crosstalk between kidney and liver in non-alcoholic fatty liver disease: mechanisms and therapeutic approaches.

Arch Physiol Biochem 2020 Mar 30:1-15. Epub 2020 Mar 30.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, Pilani, Rajasthan, India.

Liver and kidney are vital organs that maintain homeostasis and injury to either of them triggers pathogenic pathways affecting the other. For example, non-alcoholic fatty liver disease (NAFLD) promotes the progression of chronic kidney disease (CKD), vice versa acute kidney injury (AKI) endorses the induction and progression of liver dysfunction. Progress in clinical and basic research suggest a role of excessive fructose intake, insulin resistance, inflammatory cytokines production, activation of the renin-angiotensin system, redox imbalance, and their impact on epigenetic regulation of gene expression in this context. Read More

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http://dx.doi.org/10.1080/13813455.2020.1745851DOI Listing

Astragalin, (3-O-glucoside of kaempferol), isolated from leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes.

Arch Physiol Biochem 2020 Mar 27:1-7. Epub 2020 Mar 27.

Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

Inhibition of adipogenesis is crucial and is a key area of research to develop antiobesity drugs. In this study, 3-O-glucoside of kaempferol (astragalin) was isolated from leaves and evaluated for its lipolytic and antiadipogenic activity in 3T3-L1 adipocytes. Astragalin has substantially reduced the triglycerides content and lipid accumulation in 3T3-L1 adipocytes and enhanced the glycerol release in a dose dependent manner. Read More

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http://dx.doi.org/10.1080/13813455.2020.1740742DOI Listing

Brazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome.

Arch Physiol Biochem 2020 Mar 26:1-8. Epub 2020 Mar 26.

Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.

In this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model of metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD and extract, and HPD and extract. HPD increased serum interleukin-6 (IL-6) levels. Read More

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http://dx.doi.org/10.1080/13813455.2020.1743723DOI Listing

Synthesis, characterisation and enhanced apoptotic effect of gemcitabine-loaded albumin nanoparticles coating with chitosan.

Arch Physiol Biochem 2020 Mar 26:1-9. Epub 2020 Mar 26.

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Gemcitabine was loaded in albumin nanoparticles then coated with chitosan. The diameter of GEM-ANPs/CS was 200 ± 4 nm. Gemcitabine was loaded in GEM-ANPs/CS with an efficacy of 75%. Read More

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http://dx.doi.org/10.1080/13813455.2020.1742165DOI Listing

Comparison of two anti-diabetic monoestolides regarding effects on intact murine liver tissue.

Arch Physiol Biochem 2020 Mar 25:1-8. Epub 2020 Mar 25.

Department of Physiology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.

Monoestolides belonging to the fatty acid-hydroxy fatty acid (FAHFA) family have recently emerged as promising insulin sensitizers. To investigate and compare impact of two selected FAHFA isomers, namely 9-hexadecanoyloxy-octadecanoic acid [9-PAHSA] and 9-(9Z-octadecenoyloxy)-octadecanoic acid [9-OAHSA], on intact livers in C57BL/6J mice. Short-term study with intragastric gavage of 13 mg/kg of substances. Read More

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http://dx.doi.org/10.1080/13813455.2020.1743322DOI Listing

Can zaprinast and avanafil induce the levels of angiogenesis, bone morphogenic protein 2, 4 and 7 in kidney of ovariectomised rats?

Arch Physiol Biochem 2020 Mar 24:1-6. Epub 2020 Mar 24.

Department of Biochemistry, Medical Faculty, Van Yuzuncu Yıl University, Van, Turkey.

This study investigated effects of zaprinast and avanafil on angiogenesis, vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 2, 4 and 7. Female rats were randomly divided into four groups ( = 6). Sham; abdomen was approximately 2 cm opened and closed. Read More

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http://dx.doi.org/10.1080/13813455.2020.1740743DOI Listing

Spirulina reduces diet-induced obesity through downregulation of lipogenic genes expression in .

Arch Physiol Biochem 2020 Mar 24:1-9. Epub 2020 Mar 24.

INSERM U1231, University of Burgundy Franche-Comté, Dijon, France.

The present study evaluates the protective effect of spirulina against diet-induced obesity and metabolic disorders in , an animal model of metabolic syndrome. lives on a low-energy diet, in order to remain healthy. However, under a standard laboratory chow diet (SLCD), this animal exhibits insulin resistance, which occurs as a result of obesity. Read More

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http://dx.doi.org/10.1080/13813455.2020.1743724DOI Listing

Some sulfonamides as aldose reductase inhibitors: therapeutic approach in diabetes.

Arch Physiol Biochem 2020 Mar 23:1-6. Epub 2020 Mar 23.

Department of Chemistry, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Turkey.

In this study, aldose reductase (AR) was purified from sheep kidney using chromatographic methods and examined the interactions between some sulfonamides and the enzyme. According to results, sulfonamides display effective inhibitor features for sheep kidney AR with IC values in the range of 37.27-87. Read More

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http://dx.doi.org/10.1080/13813455.2020.1742166DOI Listing

Evaluation of changing the pattern of CTRP5 and inflammatory markers levels in patients with coronary artery disease and type 2 diabetes mellitus.

Arch Physiol Biochem 2020 Mar 23:1-6. Epub 2020 Mar 23.

Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

It has recently found that adipokines, play a numerous functional roles in inflammation, lipids and glucose metabolism and in the pathogenically conditions such as atherosclerosis and insulin resistance. Therefore, for the first time we aimed the present study to evaluating serum levels of CTRP5 and inflammatory cytokines patients with CAD and T2DM in comparison with controls. This study was done on 44 patients with CAD, 45 type 2 diabetes mellitus (T2DM), 41 CAD + T2DM and 41 controls. Read More

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http://dx.doi.org/10.1080/13813455.2020.1742164DOI Listing