534 results match your criteria Archives of osteoporosis[Journal]


Incidence and excess mortality of hip fractures in a predominantly Caucasian population in the South of Brazil.

Arch Osteoporos 2019 Apr 16;14(1):47. Epub 2019 Apr 16.

Endocrine Center of UFPR, Universidade Federal do Paraná, Curitiba, Brazil.

Introduction: Osteoporosis is a very common disease, and data on its epidemiology is important for health care strategy implementation. Brazil is a developing country; its population is aging, leading to an expected increase in hip fractures and their undesirable consequences.

Objective: Assess the incidence of osteoporotic hip fractures and subsequent mortality in Southern Brazil as part of a large epidemiological study aiming to reinforce the data for FRAX Brazil. Read More

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http://dx.doi.org/10.1007/s11657-019-0597-yDOI Listing

Endocrine parameters in association with bone mineral accrual in young female vocational ballet dancers.

Arch Osteoporos 2019 Apr 9;14(1):46. Epub 2019 Apr 9.

Research Centre for Sport, Exercise and Performance, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Walsall Campus, Gorway Rd, Walsall, WS1 3BD, UK.

Less is known on bone mass gains in dancers involved in vocational dance training. The present study found that, as young vocational dancers progress on their professional training, their bone health remains consistently lower compared to non-exercising controls. Endocrine mechanisms do not seem to explain these findings. Read More

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http://dx.doi.org/10.1007/s11657-019-0596-zDOI Listing

Differing impact of clinical factors on the risk of fracture in younger and older women in the general population and an osteoporosis clinic population.

Arch Osteoporos 2019 Apr 8;14(1):45. Epub 2019 Apr 8.

Quantify Research, Stockholm, Sweden.

This study assesses the impact of risk factors for fracture in women aged 80+ and 60-79. The results suggest that risk assessment which fits younger women may not be suited for the 80+ strata as many common risk factors are less predictive in the older compared to the younger cohort.

Purpose: This study assesses whether the impact of classical risk factors for fracture due to osteoporosis is different in women aged 80+ and women aged 60-79. Read More

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http://dx.doi.org/10.1007/s11657-019-0592-3DOI Listing
April 2019
1 Read

Secondary prevention of minor trauma fractures: the effects of a tailored intervention-an observational study.

Arch Osteoporos 2019 Mar 29;14(1):44. Epub 2019 Mar 29.

Department of Orthopaedic and Trauma Surgery, Cantonal Hospital Lucerne, Spitalstrasse, Lucerne, 6000, Switzerland.

Introduction: Minor trauma fractures (MTF) in the elderly are associated with an increase in mortality, morbidity, and the risk of subsequent fractures. Often, these patients who sustain MTF have an underlying bone disease, such as osteopenia or osteoporosis. Osteoporosis is known to be underdiagnosed and undertreated, and adequate treatment is essential to reduce the occurrence of MTFs. Read More

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http://dx.doi.org/10.1007/s11657-019-0595-0DOI Listing
March 2019
1 Read

The effect of a multidisciplinary co-management program for the older hip fracture patients in Beijing: a "pre- and post-" retrospective study.

Arch Osteoporos 2019 Mar 22;14(1):43. Epub 2019 Mar 22.

Department of Orthopaedic and Traumatology, Beijing Jishuitan Hospital, Beijing, China.

Hip fracture becomes a major public health issue with the growing aging population. This study evaluated a multidisciplinary co-management program for older hip fracture patients and found it significantly improved the best practice indicators. It provided preliminary evidence to support the use of such intervention in hip fracture management. Read More

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http://dx.doi.org/10.1007/s11657-019-0594-1DOI Listing
March 2019
1 Read

Adherence to bisphosphonates in the general population: a study in patients referred to a primary care service.

Arch Osteoporos 2019 Mar 21;14(1):42. Epub 2019 Mar 21.

Department of Internal Medicine and Medical Disciplines, "Sapienza" Rome University, Viale del Policlinico 155, 00161, Rome, Italy.

Purpose: The aim of the study was to evaluate the adherence to treatment with bisphosphonates in women with postmenopausal osteoporosis referred to a primary care clinic.

Methods: A total of 7257 outpatients were referred to the primary care service where the study was conducted. We retrieved data of postmenopausal women to which bisphosphonates have been prescribed in the period January 1, 2000-December 31, 2014, and analyzed the group of patients who had discontinued the drug. Read More

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http://link.springer.com/10.1007/s11657-019-0593-2
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http://dx.doi.org/10.1007/s11657-019-0593-2DOI Listing
March 2019
4 Reads

Oral bisphosphonate use and the risk of female breast, ovarian, and cervical cancer: a nationwide population-based cohort study.

Arch Osteoporos 2019 Mar 19;14(1):41. Epub 2019 Mar 19.

Department of Family Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Bisphosphonate use was not associated with the risk of female breast, ovarian, or cervical cancer. The results according to bisphosphonate type or concurrent drug uses were not associated with the cancer risk. The protective effect of bisphosphonate use on female breast cancer was significant in the low comorbidity group. Read More

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http://dx.doi.org/10.1007/s11657-019-0588-zDOI Listing
March 2019
1 Read

Predictors of long-term survival after hip fractures?-5-year results of a prospective study in Germany.

Arch Osteoporos 2019 Mar 16;14(1):40. Epub 2019 Mar 16.

Center for Orthopaedics and Trauma Surgery, University Hospital Giessen and Marburg GmbH, Baldingerstrasse, 35043, Marburg, Germany.

The incidence of hip fractures is increasing due to demographic transition. Data on long-term survival and influencing factors are sparse. Our prospective observational study with 395 patients shows a survival of 38% after 5 years. Read More

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http://dx.doi.org/10.1007/s11657-019-0586-1DOI Listing
March 2019
1 Read

The 2018 Guidelines for the diagnosis and treatment of osteoporosis in Greece.

Arch Osteoporos 2019 Mar 15;14(1):39. Epub 2019 Mar 15.

Hellenic Society for the Study of Bone Metabolism, Athens, Greece.

We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting.

Purpose: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011.

Methods: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece. Read More

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http://dx.doi.org/10.1007/s11657-019-0584-3DOI Listing

Epidemiological and clinical study of hip fracture in hospitalized elderly patients in Shanghai, China.

Arch Osteoporos 2019 Mar 12;14(1):37. Epub 2019 Mar 12.

Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Shanghai, 200040, China.

In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications.

Introduction: We attempted to explore the epidemiology and clinical characteristics of hip fracture in the elderly. Read More

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http://dx.doi.org/10.1007/s11657-019-0580-7DOI Listing
March 2019
2 Reads

Stages of sarcopenia, bone mineral density, and the prevalence of osteoporosis in older women.

Arch Osteoporos 2019 Mar 13;14(1):38. Epub 2019 Mar 13.

Faculty of Physical Education, University of Brasília, Asa Norte, Brasilia, Distrito Federal, 70910-900, Brazil.

A better understanding of the relationship between osteoporosis and sarcopenia may help to develop effective preventive and therapeutic strategies. In the present study, the association between different stages of sarcopenia, BMD, and osteoporosis was examined. The salient findings indicate that a dose-response relationship exists between sarcopenia stages and bone-related phenotypes. Read More

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http://link.springer.com/10.1007/s11657-019-0591-4
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http://dx.doi.org/10.1007/s11657-019-0591-4DOI Listing
March 2019
15 Reads

Association between serum high-density lipoprotein cholesterol and bone health in the general population: a large and multicenter study.

Arch Osteoporos 2019 Mar 9;14(1):36. Epub 2019 Mar 9.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.

This study was a cross-sectional study and enrolled 14,147 participants after excluding. We performed a large number of data analyses to indicate that HDL-C levels were related to bone health. A high HDL-C level is an independent risk factor for bone loss both in males and females. Read More

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http://link.springer.com/10.1007/s11657-019-0579-0
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http://dx.doi.org/10.1007/s11657-019-0579-0DOI Listing
March 2019
3 Reads

Effects of denosumab on bone metabolism and bone mineral density in kidney transplant patients: a systematic review and meta-analysis.

Arch Osteoporos 2019 Mar 9;14(1):35. Epub 2019 Mar 9.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 N. State St, Jackson, MS, 39216, USA.

Objective: The use of immunosuppressive agents, especially glucocorticoids, are associated with increased risks of bone loss in kidney transplant patients. Denosumab, a potent antiresorptive agent, has been shown to increase bone mineral density (BMD) in patients with CKD. However, its effects on bone metabolism and BMD in kidney transplant patients remain unclear. Read More

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http://dx.doi.org/10.1007/s11657-019-0587-0DOI Listing
March 2019
1 Read

The association between hepatitis and osteoporosis: a nested case-control study using a national sample cohort.

Arch Osteoporos 2019 Mar 9;14(1):34. Epub 2019 Mar 9.

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, South Korea.

The prevalence of hepatitis B was higher in osteoporosis patients than the control group, especially in females. However, the prevalence of hepatitis C was not different. The matching for various factors improved to have same conditions between osteoporosis patients and the control group. Read More

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http://dx.doi.org/10.1007/s11657-019-0590-5DOI Listing
March 2019
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Revised FRAX®-based intervention thresholds for the management of osteoporosis among postmenopausal women in Sri Lanka.

Arch Osteoporos 2019 Mar 9;14(1):33. Epub 2019 Mar 9.

Department of Pharmacy, Faculty of Allied Health Sciences, Galle, Sri Lanka.

This paper revised the fixed intervention thresholds (ITs) based on the Sri Lankan fracture risk assessment tool (FRAX) published in 2013 and introduced new ITs, hybrid and two-tier, aiming to help clinicians in the management of postmenopausal osteoporosis. The hybrid and two-tier ITs have a better discriminatory power than age-dependent and revised fixed ITs.

Introduction: This study revised the Sri Lankan FRAX®-based intervention thresholds (ITs) previously published in 2013. Read More

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http://dx.doi.org/10.1007/s11657-019-0585-2DOI Listing
March 2019
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The epidemiology of osteoporosis, associated fragility fractures, and management gap in China.

Authors:
Fan Yu Weibo Xia

Arch Osteoporos 2019 Mar 8;14(1):32. Epub 2019 Mar 8.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese, Academy of Medical Science, Shuaifuyuan No. 1, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Osteoporosis has been one of the most common but largely under-diagnosed clinical problems among elderly population. The disease burden is even greater in China because of limited medical resources and large population size. This article is aimed to provide an overview of disease burden, secular trend, and management gap of osteoporosis and related fractures in China. Read More

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http://dx.doi.org/10.1007/s11657-018-0549-yDOI Listing
March 2019
2 Reads

Body compositions differently contribute to BMD in different age and gender: a pilot study by QCT.

Arch Osteoporos 2019 Mar 7;14(1):31. Epub 2019 Mar 7.

Department of Radiology, Shanghai TenthPeople's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

The study was to investigate the correlation between body compositions and bone mineral density (BMD) and to evaluate the body composition contribution to BMD. In male, LM showed positive effect on BMD. In female, SAT showed positive, and FM and F/L showed negative effect on BMD. Read More

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http://dx.doi.org/10.1007/s11657-019-0574-5DOI Listing
March 2019
8 Reads

Celiac disease and severe vitamin D deficiency: the case for anti-tissue transglutaminase antibody screening.

Authors:
Riad A Sulimani

Arch Osteoporos 2019 Mar 4;14(1):30. Epub 2019 Mar 4.

Department of Internal Medicine, College of Medicine, King Saud University, P.O Box 7805, Riyadh, 11472, Saudi Arabia.

Vitamin D-deficient Saudi adolescent girls were screened for anti-tissue transglutaminase (IgA-tTG) antibodies to determine whether the presence of severe vitamin D deficiency was associated with celiac disease. All 9 participants who were positive for IgA-tTG antibodies had severe vitamin D deficiency (25(OH)D < 12.5 nmol/l), suggesting that this population should be screened for celiac disease. Read More

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http://dx.doi.org/10.1007/s11657-018-0554-1DOI Listing
March 2019
1 Read

Physical activity as measured by accelerometer in NHANES 2005-2006 is associated with better bone density and trabecular bone score in older adults.

Arch Osteoporos 2019 Mar 2;14(1):29. Epub 2019 Mar 2.

Section of Endocrinology, Diabetes, and Metabolism, University of Chicago Medicine, Chicago, IL, 60611, USA.

In an analysis of NHANES 2005-2006, older, but not younger, women and men with higher levels of physical activity had higher TBS, total hip T-score, and femoral neck T-score. Even modest levels of physical activity may be a crucial component of bone health maintenance.

Purpose: Physical activity is associated with improved bone parameters in adolescence, but it is not clear if this persists into adulthood. Read More

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http://dx.doi.org/10.1007/s11657-019-0583-4DOI Listing
March 2019
1 Read

The Dutch Hip Fracture Audit: evaluation of the quality of multidisciplinary hip fracture care in the Netherlands.

Arch Osteoporos 2019 Mar 1;14(1):28. Epub 2019 Mar 1.

Department of Trauma Surgery, Ziekenhuisgroep Twente, Almelo-Hengelo, The Netherlands.

The nationwide Dutch Hip Fracture Audit (DHFA) is initiated to improve the quality of hip fracture care by providing insight into the actual quality of hip fracture care in daily practice. The baseline results demonstrate variance in practice, providing potential starting points to improve the quality of care.

Purpose: The aim of this study is to describe the development and initiation of the DHFA. Read More

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http://dx.doi.org/10.1007/s11657-019-0576-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397305PMC
March 2019
1 Read

Exploring the association between number, severity, location of fracture, and occiput-to-wall distance.

Arch Osteoporos 2019 Feb 28;14(1):27. Epub 2019 Feb 28.

Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.

This study of women with a suspected vertebral fracture determined the association between vertebral fracture characteristics and posture. The number of fractures was associated with posture. Severity of fracture was associated with posture when adjusting for pain. Read More

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http://dx.doi.org/10.1007/s11657-019-0582-5DOI Listing
February 2019
1 Read

Bone age as a correction factor for the analysis of trabecular bone score (TBS) in children.

Arch Osteoporos 2019 Feb 27;14(1):26. Epub 2019 Feb 27.

Clinical Epidemiology Unit, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

Trabecular bone score (TBS) is a tool to improve evaluation of DXA scans, barely used in children. We proposed to evaluate TBS with bone age (BA) compared to chronological age (CA). In girls, TBS value using BA is constant until age 8, and in boys until age 10, and then starts to increase steadily. Read More

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http://dx.doi.org/10.1007/s11657-019-0573-6DOI Listing
February 2019
3 Reads

Correction to: Estimated expenditures for hip fractures using merged healthcare insurance data for individuals aged ≥ 75 years and long-term care insurance claims data in Japan.

Arch Osteoporos 2019 Feb 27;14(1):25. Epub 2019 Feb 27.

Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

The article Estimated expenditures for hip fractures using merged healthcare insurance data for individuals aged ≥ 75 years and long-term care insurance claims data in Japan. Read More

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http://dx.doi.org/10.1007/s11657-019-0562-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394440PMC
February 2019

Risk factors for conservative treatment failure in acute osteoporotic vertebral compression fractures (OVCFs).

Arch Osteoporos 2019 Feb 26;14(1):24. Epub 2019 Feb 26.

Department of Spine Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 76 Nanguo Road, Nanshao gate, Xi'an, 710054, Shaan'xi Province, China.

This study aimed to identify risk factors for failure of conservative treatment of acute OVCFs. The results showed age, BMD, BMI, mFI, and IVC were high-risk factors for failure of conservative treatment of acute OVCFs.

Purpose: This study aimed to identify risk factors for failure of conservative treatment of acute osteoporotic vertebral compression fractures (OVCFs). Read More

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http://dx.doi.org/10.1007/s11657-019-0563-8DOI Listing
February 2019
3 Reads

Changes in femoral bone mineral density after total knee arthroplasty: a systematic review and meta-analysis.

Arch Osteoporos 2019 Feb 23;14(1):23. Epub 2019 Feb 23.

Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, UWMF Centennial Building, 1685 Highland Avenue, 6th Floor, Madison, WI, 53705, USA.

Background: Bone loss after total knee arthroplasty (TKA) may lead to periprosthetic fractures that are associated with significant costs (morbidity, economic, etc.) and pose a challenge to operative fixation. This meta-analysis quantifies the change in bone mineral density (BMD) of the distal femur after primary TKA. Read More

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http://dx.doi.org/10.1007/s11657-019-0572-7DOI Listing
February 2019
2 Reads

Vitamin D cutoff point in relation to parathyroid hormone: a population based study in Riyadh city, Saudi Arabia.

Arch Osteoporos 2019 Feb 20;14(1):22. Epub 2019 Feb 20.

Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.

The current recommended cutoff value for low vitamin D may result in overestimation of hypovitaminosis D. Vitamin D levels at 30.0 nmol/L can diagnose the hyperparathyroid cases leading to bone loss, with moderate accuracy, in the Saudi population. Read More

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http://dx.doi.org/10.1007/s11657-019-0565-6DOI Listing
February 2019
1 Read

Ex vivo cortical porosity and thickness predictions at the tibia using full-spectrum ultrasonic guided-wave analysis.

Arch Osteoporos 2019 Feb 20;14(1):21. Epub 2019 Feb 20.

Berlin-Brandenburg School for Regenerative Therapies (BSRT), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

The estimation of cortical thickness (Ct.Th) and porosity (Ct.Po) at the tibia using axial transmission ultrasound was successfully validated ex vivo against site-matched micro-computed tomography. Read More

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http://dx.doi.org/10.1007/s11657-019-0578-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394459PMC
February 2019

Osteoporosis strategic plan for the Middle East and North Africa region.

Arch Osteoporos 2019 Feb 14;14(1):20. Epub 2019 Feb 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Shariati Hospital, Tehran University of Medical Sciences, Kargar st., Tehran, Iran.

The first step to achieve a world without fragility fractures is to devise a strategic plan to improve research and planning, and assisting member states to acquire the required financial, technical, and other resources. This article aims to outline the first strategic plan devised for the Middle East and North Africa region proposed by the International Osteoporosis Foundation's (IOF) Middle East and North Africa (MENA) Regional Advisory Council (RAC).

Purpose: Osteoporosis is no exception in this rising tide of non-communicable diseases, not only sharing common risk factors but also contributing substantially to a heavy social and economic burden on society. Read More

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http://dx.doi.org/10.1007/s11657-019-0567-4DOI Listing
February 2019
1 Read

Rationale, study design, and descriptive data of the Lucky Bone™ Fracture Liaison Service.

Arch Osteoporos 2019 Feb 12;14(1):19. Epub 2019 Feb 12.

CIUSSS Nord de l'Ile de Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 bl. Gouin ouest, Montreal, QC, H4J 1C5, Canada.

The study design of a multidisciplinary Fracture Liaison Service (2-year follow-up) aiming to optimize fragility fracture management in an outpatient setting is presented. Patient characteristics, investigation, and treatment initiation data at baseline were recorded. Results corroborate the care gap in osteoporosis management, reinforcing the need for secondary fracture prevention programs. Read More

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http://dx.doi.org/10.1007/s11657-019-0571-8DOI Listing
February 2019
2 Reads

Automated quantitative morphometry of vertebral heights on spinal radiographs: comparison of a clinical workflow tool with standard 6-point morphometry.

Arch Osteoporos 2019 Feb 11;14(1):18. Epub 2019 Feb 11.

Department of Radiology, University of California, San Francisco, CA, USA.

A workflow tool for measurements of vertebral heights on lateral spine radiographs based on automated placements of 6 points per vertebra was evaluated. The tool helps to standardize point placement among operators. Its success rate is very good in normal vertebrae but lower in vertebrae with more severe fractures. Read More

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http://dx.doi.org/10.1007/s11657-019-0577-2DOI Listing
February 2019

Physical activity modifies the effect of calcium supplements on bone loss in perimenopausal and postmenopausal women: subgroup analysis of a randomized controlled trial.

Arch Osteoporos 2019 Feb 8;14(1):17. Epub 2019 Feb 8.

Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

We aimed to determine whether the effect of calcium supplements on bone metabolism is modified by physical activity (PA) through a subgroup analysis of an RCT. PA may be a favorable effect modifier of the association between calcium intake and bone loss in perimenopausal and postmenopausal women.

Purpose: Physical exercise can potentially modify bone metabolism. Read More

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http://dx.doi.org/10.1007/s11657-019-0575-4DOI Listing
February 2019

Glucocorticoid-induced osteoporosis preventive care in rheumatology patients.

Arch Osteoporos 2019 Feb 5;14(1):16. Epub 2019 Feb 5.

Department of Medicine, Division of Rheumatology, University of Alberta, 8-130 Clinical Sciences Building, 11350 83rd Avenue NW, Edmonton, AB, T6G 2G3, Canada.

Glucocorticoid-induced osteoporosis (GIOP) is common in patients prescribed with long-term glucocorticoids. Guidelines suggest patients receiving moderate-dose glucocorticoid therapy receive GIOP preventive care. Previous studies have shown preventive care rates are not optimal. Read More

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http://dx.doi.org/10.1007/s11657-019-0570-9DOI Listing
February 2019
2 Reads

Knowledge, attitudes, beliefs, and health behaviors of bone health among Caribbean Hispanic/Latino adults.

Arch Osteoporos 2019 Feb 4;14(1):14. Epub 2019 Feb 4.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, 3 Solomont Way, Suite 4, Lowell, MA, 01854, USA.

Few studies have examined knowledge and perceptions of osteoporosis among Caribbean Latino adults. Confusion regarding the term osteoporosis was noted. Doctors were viewed as trusted sources of health information, although descriptions of a paradoxical relationship emerged. Read More

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http://dx.doi.org/10.1007/s11657-019-0566-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448586PMC
February 2019
9 Reads

Effect of abaloparatide on vertebral, nonvertebral, major osteoporotic, and clinical fractures in a subset of postmenopausal women at increased risk of fracture by FRAX probability.

Arch Osteoporos 2019 Feb 5;14(1):15. Epub 2019 Feb 5.

Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.

We evaluated the efficacy of abaloparatide in women who were at increased risk for fracture, based on CHMP recommended risk thresholds, at the Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) study baseline. Among patients at high risk based on FRAX probabilities, 18 months of abaloparatide significantly decreased risk for all fracture endpoints compared with placebo.

Purpose: Abaloparatide, a novel anabolic agent for the treatment of postmenopausal osteoporosis, significantly reduced the risk of vertebral and nonvertebral fractures in the ACTIVE study compared with placebo. Read More

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http://dx.doi.org/10.1007/s11657-019-0564-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373333PMC
February 2019
2 Reads

Imminent fracture risk assessments in the UK FLS setting: implications and challenges.

Arch Osteoporos 2019 Feb 2;14(1):12. Epub 2019 Feb 2.

Nuffield Department of Orthopaedics, Rheumatology and Orthopaedic Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s11657-019-0569-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398567PMC
February 2019

Bone mineral density and its correlation with vitamin D status in healthy school-going children of Western India.

Arch Osteoporos 2019 Feb 2;14(1):13. Epub 2019 Feb 2.

Department of Pediatrics, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

Studies on vitamin D deficiency status and its impact on bone health in a developing country are limited. We assessed the bone mineral density and vitamin D levels in healthy school-going children of Western India. Around 65% children had vitamin D deficiency and vitamin D levels had good correlation with bone mineral density. Read More

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http://link.springer.com/10.1007/s11657-019-0568-3
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http://dx.doi.org/10.1007/s11657-019-0568-3DOI Listing
February 2019
4 Reads

An observational cohort study to produce and evaluate an improved tool to screen older women with back pain for osteoporotic vertebral fractures (Vfrac): study protocol.

Arch Osteoporos 2019 Jan 25;14(1):11. Epub 2019 Jan 25.

Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.

The aim of this study is to produce an easy to use checklist for general practitioners to complete whenever a woman aged over 65 years with back pain seeks healthcare. This checklist will produce a binary output to determine if the patient should have a radiograph to diagnose vertebral fracture.

Purpose: People with osteoporotic vertebral fractures are important to be identified as they are at relatively high risk of further fractures. Read More

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http://dx.doi.org/10.1007/s11657-019-0558-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347587PMC
January 2019
2 Reads

Serum 25-hydroxy-vitamin D and the risk of fractures in the teriparatide versus risedronate VERO clinical trial.

Arch Osteoporos 2019 Jan 18;14(1):10. Epub 2019 Jan 18.

CHU Brugmann, ULB, Brussels, Belgium.

Purpose: Using data from the 2-year, randomized, double-dummy VERO trial, we examined the changes in 25-hydroxy-vitamin D (25[OH]D) concentrations over time, and whether the fracture risk reduction of teriparatide versus risedronate varies by baseline 25(OH)D sufficiency category.

Methods: Postmenopausal women with established osteoporosis received subcutaneous daily teriparatide 20 μg or oral weekly risedronate 35 mg, with concomitant 500-1000 mg of elemental calcium and 400-800 IU/day of vitamin D supplements. Fracture endpoints were analyzed by predefined subgroups of 25(OH)D insufficient and sufficient patients. Read More

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http://dx.doi.org/10.1007/s11657-019-0561-xDOI Listing
January 2019
8 Reads

Osteoporosis knowledge and awareness among university students in Saudi Arabia.

Arch Osteoporos 2019 Jan 14;14(1). Epub 2019 Jan 14.

Biochemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

Awareness and knowledge about any disease is the first step to prevent and treat it, so this study evaluates osteoporosis awareness and knowledge in university students. Our results showed a high awareness and good knowledge of osteoporosis. Females were better informed than males. Read More

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http://link.springer.com/10.1007/s11657-019-0560-y
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http://dx.doi.org/10.1007/s11657-019-0560-yDOI Listing
January 2019
16 Reads

An epidemiological evaluation of fractures and its determinants among Lebanese schoolchildren: a cross-sectional study.

Arch Osteoporos 2019 Jan 15;14(1). Epub 2019 Jan 15.

Division of Endocrinology, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon.

The purpose of this study is to establish the prevalence and determinants of fractures among 974 Lebanese schoolchildren aged 8-18. Fractures might be less common in the Lebanese pediatric population compared to western populations. Male gender and high SES are independent risk factors for fractures, while 25(OH)D and BMI have no impact. Read More

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http://dx.doi.org/10.1007/s11657-019-0559-4DOI Listing
January 2019

An unusual Chinese case of celiac disease presenting as hypocalcemia and low bone density.

Arch Osteoporos 2019 Jan 10;14(1). Epub 2019 Jan 10.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.

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http://link.springer.com/10.1007/s11657-019-0557-6
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http://dx.doi.org/10.1007/s11657-019-0557-6DOI Listing
January 2019
10 Reads

Risk factors for loss of bone mineral density after curative esophagectomy.

Arch Osteoporos 2019 Jan 9;14(1). Epub 2019 Jan 9.

Metabolic Medicine, University College Dublin, Conway Institute of Biomedical and Biomolecular Research, Dublin 4, Ireland.

Micronutrient and fat malabsorption and altered enteroendocrine signaling occur after esophagectomy for cancer; however, the impact of malnutrition on bone health in this cohort has not been previously investigated. In this study, the prevalence of osteoporosis increased after curative surgery, associated with disease-specific, treatment-related, and population risk factors.

Purpose: Improved oncologic outcomes in esophageal cancer (EC) have resulted in increased survivorship and a focus on long-term quality of life. Read More

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http://link.springer.com/10.1007/s11657-018-0556-z
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http://dx.doi.org/10.1007/s11657-018-0556-zDOI Listing
January 2019
18 Reads

Effect of treatment on back pain and back extensor strength with a spinal orthosis in older women with osteoporosis: a randomized controlled trial.

Arch Osteoporos 2019 Jan 9;14(1). Epub 2019 Jan 9.

Division of Family Medicine and Primary Care, department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.

The treatment effect of an activating spinal orthosis on back pain and back extensor strength was compared to a training group and to a control group. Between the groups, there was no significant difference in back pain, back extensor strength, or kyphosis index after the 6 months of treatment.

Purpose: The aim of this study was to study the effect of treatment with an activating spinal orthosis on back pain, back extensor strength, and kyphotic index. Read More

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http://link.springer.com/10.1007/s11657-018-0555-0
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http://dx.doi.org/10.1007/s11657-018-0555-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325994PMC
January 2019
1 Read

Vitamin D supplementation and muscle strength in pre-sarcopenic elderly Lebanese people: a randomized controlled trial.

Arch Osteoporos 2018 Dec 19;14(1). Epub 2018 Dec 19.

Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, 63000, Clermont-Ferrand, France.

Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in muscle mass and muscle strength. In our study, vitamin D supplementation showed significant improvements in vitamin D concentrations as well as appendicular muscle mass in pre-sarcopenic older Lebanese people. However, we found no significant effect on muscle strength. Read More

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http://dx.doi.org/10.1007/s11657-018-0553-2DOI Listing
December 2018

Association between visual classification of kyphosis and future ADL decline in community-dwelling elderly people: the Kurabuchi study.

Arch Osteoporos 2018 Dec 18;14(1). Epub 2018 Dec 18.

Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16 Omorinishi, Ota-ku, Tokyo, 143-8540, Japan.

This cohort study conducted in Japan showed that severe age-related kyphosis was visually detected. The visual assessment of kyphosis was associated with declines in ADL, suggesting that we can easily identify people at high risk to develop future ADL reduction in the community setting.

Purpose: Age-related kyphosis is related with declines in activities of daily living (ADL). Read More

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http://dx.doi.org/10.1007/s11657-018-0551-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299049PMC
December 2018
1 Read

Oral bisphosphonates and incidence of cancers in patients with osteoporosis: a systematic review and meta-analysis.

Arch Osteoporos 2018 Dec 17;14(1). Epub 2018 Dec 17.

Department of Oncology, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining, 810000, China.

Purpose: Several previous studies have shown that oral bisphosphonates (BPs) are associated with the incidence of 13 specific cancers, including lung cancer, esophageal cancer, gastric cancer, and colorectal cancer (CRC). However, the findings are heterogeneous.

Methods And Results: Relevant studies published in databases such as PubMed, Embase database, and Cochrane library were systematically retrieved from inception to August 25th, 2018, regardless of language, by two investigators independently. Read More

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http://dx.doi.org/10.1007/s11657-018-0552-3DOI Listing
December 2018

Sarcopenia-related features and factors associated with low muscle mass, weak muscle strength, and reduced function in Chinese rural residents: a cross-sectional study.

Arch Osteoporos 2018 Dec 17;14(1). Epub 2018 Dec 17.

Research Center of Sports and Health Science, Division of Sports Science and Physical Education, Tsinghua University, No.1 Tsinghua Yuan, Haidian District, Beijing, 100084, China.

Muscle strength and function declined more than the concomitant loss of muscle mass. Measures of muscle strength and function are an effective way to assess functional ability and physical health in older people. A healthy lifestyle such as physical exercise, good nutrition, and higher BMI can benefit older people. Read More

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http://dx.doi.org/10.1007/s11657-018-0545-2DOI Listing
December 2018
1 Read

Bone mineral density, vitamin D status, and calcium intake in healthy female university students from different socioeconomic groups in Turkey.

Arch Osteoporos 2018 Dec 4;13(1):135. Epub 2018 Dec 4.

Department of Nuclear Medicine, School of Medicine, Celal Bayar University, Manisa, Turkey.

Peak bone mass is reached in late adolescence. Low peak bone mass is a well recognized risk factor for osteoporosis later in life. Our data do not support a link between vitamin D status, bone mineral density (BMD), and socioeconomic status (SES). Read More

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http://link.springer.com/10.1007/s11657-018-0482-0
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http://dx.doi.org/10.1007/s11657-018-0482-0DOI Listing
December 2018
19 Reads

Initial hospitalization with rigorous bed rest followed by bracing and rehabilitation as an option of conservative treatment for osteoporotic vertebral fractures in elderly patients: a pilot one arm safety and feasibility study.

Arch Osteoporos 2018 Nov 23;13(1):134. Epub 2018 Nov 23.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba-city, Ibaraki, 305-8575, Japan.

We assessed the safety and feasibility of a unified conservative treatment protocol for osteoporotic vertebral fractures in the elderly patients with a 24-week follow-up. Our results showed that initial hospitalization with rigorous bed rest followed by a rehabilitation program using a Jewett brace was safe and feasible in managing patients.

Purpose: The purpose of this study was to prove the safety and feasibility of a unified conservative treatment protocol, which included initial hospitalization with rigorous bed rest followed by a rehabilitation program with Jewett brace for osteoporotic vertebral fractures (OVFs) in the elderly patients with a 24-week follow-up. Read More

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http://dx.doi.org/10.1007/s11657-018-0547-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267386PMC
November 2018
15 Reads

Referral pattern for DXA scanning in a tertiary care centre from southern India.

Arch Osteoporos 2018 Nov 20;13(1):133. Epub 2018 Nov 20.

Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

Referral patterns for bone mineral density testing by dual energy X-ray absorptiometry (DXA) scanning are seldom studied. In our study, the overall proportion of referrals from specialties remained low. This highlights the need for adequate utilisation of DXA by specialties treating subjects at risk for osteoporosis. Read More

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http://dx.doi.org/10.1007/s11657-018-0548-zDOI Listing
November 2018
19 Reads