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    1373 results match your criteria Archives of medical science : AMS[Journal]

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    Race, sense of control over life, and short-term risk of mortality among older adults in the United States.
    Arch Med Sci 2017 Aug 9;13(5):1233-1240. Epub 2016 May 9.
    Department of Psychiatry and Center for Research on Ethnicity, Culture, and Health (CRECH), University of Michigan, Ann Arbor, USA.
    Introduction: Sense of control over life has been shown to have protective health effects in studies that have mostly enrolled White middle class individuals. It is unknown, however, whether populations differ in the protective health gain associated with sense of control over life. This study compared a nationally representative sample of Black and White older adults for protective effects of sense of control over life on short-term risk of all-cause mortality in the United States. Read More

    Does genetic testing for ERα gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women?
    Arch Med Sci 2017 Aug 22;13(5):1224-1232. Epub 2016 Sep 22.
    Department for Woman Health, Institute of Rural Health, Lublin, Poland.
    It is commonly considered that cognitive abilities decrease with age, especially with respect to processing and psychomotor speed. It is an interesting issue whether, apart from the ageing process, the undergoing of menopause itself deteriorates cognitive functions, compared to women at reproductive age. Hopes for improvement of cognitive functions were pinned on the use of menopausal hormone therapy. Read More

    The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications.
    Arch Med Sci 2017 Aug 13;13(5):1217-1223. Epub 2017 Jan 13.
    Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
    Hemorrhagic stroke, accounting for 10-30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. Read More

    The evolution of natriuretic peptide augmentation in management of heart failure and the role of sacubitril/valsartan.
    Arch Med Sci 2017 Aug 3;13(5):1207-1216. Epub 2017 Jul 3.
    Cardiology Division, Department of Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY, USA.
    Heart failure (HF) is one of the leading causes of morbidity, mortality, and health care expenditures in the US and worldwide. For three decades, the pillars of treatment of HF with reduced ejection fraction (HFrEF) were medications that targeted the sympathetic nervous system (SNS) and the renin-angiotensin-aldosterone system (RAAS). Prior attempts to augment the natriuretic peptide system (NPS) for the management of HF failed either due to lack of significant clinical benefit or due to the unacceptable side effect profile. Read More

    Prevalence of chronic pain in the elderly Polish population - results of the PolSenior study.
    Arch Med Sci 2017 Aug 6;13(5):1197-1206. Epub 2016 Jun 6.
    International Institute of Molecular and Cell Biology, Warsaw, Poland.
    Introduction: Pain is the most common complaint of elderly people. In Poland, no large studies on the prevalence of chronic pain in the elderly were conducted until recently.

    Material And Methods: The study was a part of the PolSenior project, a cross-sectional multidisciplinary study on ageing of the Polish population, and included a randomly selected group of 716 people aged 55-59 years, and 4979 people over 65 years. Read More

    Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women.
    Arch Med Sci 2017 Aug 19;13(5):1188-1196. Epub 2017 Jul 19.
    Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
    Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women.

    Material And Methods: A total of 150 postmenopausal women were included in this cross-sectional study. Read More

    Impact of beverage consumption, age, and site dependency on dual energy X-ray absorptiometry (DEXA) measurements in perimenopausal women: a prospective study.
    Arch Med Sci 2017 Aug 14;13(5):1178-1187. Epub 2017 Feb 14.
    Department of Radiology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, China.
    Introduction: The aim of this study was to determine the best site for bone mineral density (BMD) measurements based on T-scores, age, and beverage consumption.

    Material And Methods: In this prospective study, 271 women stratified by age (average age: 61.9 years) underwent dual energy X-ray absorptiometry (DEXA) scanning of their lumbar spine, hips, and forearms. Read More

    Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia.
    Arch Med Sci 2017 Aug 17;13(5):1168-1177. Epub 2017 Jul 17.
    Department of Clinical Psychology and Neuropsychology, Institute of Psychology, University of Gdansk, Gdansk, Poland.
    Introduction: The aim of this research, based on 7 years of observations, was to assess the relationship between the dynamics of changes in the realm of cognitive functions in the early stages of observations and the presence of neuropsychiatric symptoms as well as further progression of cognitive function impairments in people diagnosed with mild cognitive impairment (MCI).

    Material And Methods: One hundred and ninety three individuals were included in the study, all of whom referred themselves to the Mental Health Clinic and were diagnosed with MCI based on the criteria of the Working Group on MCI. It was assumed that these individuals would be subjected to systematic psychiatric and neuropsychological observation until they were diagnosed with dementia. Read More

    Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction.
    Arch Med Sci 2017 Aug 23;13(5):1160-1167. Epub 2016 May 23.
    Department of Neurology, The University of Oklahoma Health Sciences Center & VA Medical Center, Oklahoma City, OK, USA.
    Introduction: Cortical atrophy is known to be a valuable sign of cognitive decline. The purpose of this study was to assess the association between low thyroid-stimulating hormone (TSH), posterior cortical atrophy (Koedam score - KS) and nitro-oxidative stress in elderly patients.

    Material And Methods: A study (SG) and a control group (CG), each subdivided by gender, were investigated. Read More

    Postmenopausal cognitive changes and androgen levels in the context of apolipoprotein E polymorphism.
    Arch Med Sci 2017 Aug 10;13(5):1148-1159. Epub 2016 Oct 10.
    Lou Ruvo Brain Wellness Center, Neurological Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA.
    Introduction: The focus of this study was to assess cognitive functions in relation to androgens and specifically testosterone and dehydroepiandrosterone in postmenopausal women as well as the correlation between cognitive functions and these two androgens according to polymorphism of the apolipoprotein E gene (APOE).

    Material And Methods: A group of 402 women was recruited to the study (minimum 2 years after the last menstruation, follicle-stimulating hormone (FSH) more than 30 U/ml and no dementia signs on Montreal Cognitive Assessment). The computerized battery of the Central Nervous System Vital Signs test was used to diagnose cognitive functions. Read More

    Interleukin-21 gene polymorphism rs2221903 is associated with disease activity in patients with rheumatoid arthritis.
    Arch Med Sci 2017 Aug 17;13(5):1142-1147. Epub 2017 Jul 17.
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
    Introduction: Interleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the IL-21 gene may alter the synthesis of IL-21. The aim of this study was to examine IL-21 and IL-21R polymorphisms in patients with RA. Read More

    Five gene variants in nonagenarians, centenarians and average individuals.
    Arch Med Sci 2017 Aug 3;13(5):1130-1141. Epub 2017 Aug 3.
    Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
    Introduction: Genetic factors contribute to the variation of human life span which is believed to be more profound after 85 years of age. The aim of the present study was to evaluate the frequency of 5 gene polymorphisms between nonagenarians, centenarians and average individuals.

    Material And Methods: Single nucleotide polymorphisms (SNPs) of telomerase reverse transcriptase (TERT; rs2736098), insulin-like growth factor-1 binding protein-3 (IGFBP3; A-202C, rs2857744), fork-head box O3A (FOXO3A; rs13217795 and rs2764264) factor and adiponectin (ADIPOQ; rs2241766) were evaluated in 405 individuals: n = 256 nonagenarians and centenarians (study group) and n = 149 average lifespan individuals (control group aged 18 - < 80 years). Read More

    Predictive abilities of baseline measurements of fluid overload, assessed by bioimpedance spectroscopy and serum N-terminal pro-B-type natriuretic peptide, for mortality in hemodialysis patients.
    Arch Med Sci 2017 Aug 19;13(5):1121-1129. Epub 2017 Jul 19.
    Nephrology Department, Dialysis and Renal Transplant Center, "Dr. C.I. Parhon" University Hospital, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Introduction: Fluid overload is one of the most important, yet modifiable, risk factors associated with worse outcomes in hemodialysis (HD) patients. However, its precise assessment in clinical practice is still under investigation.

    Material And Methods: This is an observational prospective study which included 285 stable patients with end-stage renal disease on standard thrice-weekly HD therapy. Read More

    Cardiac surgery related cardio-renal syndrome assessed by conventional and novel biomarkers - under or overestimated diagnosis?
    Arch Med Sci 2017 Aug 4;13(5):1111-1120. Epub 2017 Aug 4.
    Department of Anesthesia, Intensive Care and Acute Poisoning, Pomeranian Medical University, Szczecin, Poland.
    Introduction: Serum creatinine is a 'gold standard' criterion of recognizing and staging of acute kidney injury (AKI) despite it being a suboptimal, delayed indicator. The interpretation of increased values of biomarkers imposes great difficulty regarding cardiac surgery procedures performed with cardiopulmonary bypass and may lead to under- or overestimated diagnosis. The aim of this study was to evaluate the clinical utility of the sole serum creatinine or urine neutrophil gelatinase-associated lipocalin (NGAL) concentration used for identification of patients with AKI after cardiac surgery. Read More

    A randomized clinical trial comparing hemodynamic responses to ketamine-propofol combination (ketofol) versus etomidate during anesthesia induction in patients with left ventricular dysfunction undergoing coronary artery bypass graft surgery.
    Arch Med Sci 2017 08 25;13(5):1102-1110. Epub 2016 Oct 25.
    Department of Medical-Surgical Nursing, Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran.
    Introduction: Anesthesia induction is often accompanied by a period of hemodynamic instability, which could be a significant problem in patients with compromised ventricular function. The aim of this study is to compare the hemodynamic responses to etomidate versus a combination of ketamine and propofol (ketofol) for anesthetic induction in patients with left ventricular dysfunction undergoing coronary artery bypass graft (CABG) surgery.

    Material And Methods: In a double-blind randomized clinical study, a total of 84 patients with ischemic left ventricular dysfunction (EF < 40%) were randomly assigned to two groups (A and B). Read More

    Improvement of exercise tolerance in cardiopulmonary testing with sustained safety after regular training in outpatients with systolic heart failure (NYHA III) and an implantable cardioverter-defibrillator. Prospective 18-month randomized study.
    Arch Med Sci 2017 Aug 23;13(5):1094-1101. Epub 2016 Aug 23.
    2 Department of Coronary Artery Disease, Institute of Cardiology, Warsaw, Poland.
    Introduction: The aim of the study was to evaluate the impact of individual training on the level of physical capacity and echocardiographic parameters in patients with systolic heart failure (SHF), NYHA III and an implantable cardioverter-defibrillator (ICD).

    Material And Methods: The study included 84 patients with SHF, randomly assigned to one of two groups: with regular training (ICD-Ex) and a control group (ICD-control). The ICD-Ex group participated in a hospital rehabilitation program which after discharge was individually continued for 6 months in an outpatient setting. Read More

    C-reactive protein levels predict systolic heart failure and outcome in patients with first ST-elevation myocardial infarction treated with coronary angioplasty.
    Arch Med Sci 2017 Aug 3;13(5):1086-1093. Epub 2017 Aug 3.
    Department of Cardiology, University of Erlangen-Nuremberg, Erlangen, Germany.
    Introduction: There is growing evidence that inflammation plays a pivotal role in the etiology and progression of atherosclerosis. High C-reactive protein (CRP) levels have been associated with high mortality in patients with acute myocardial infarction (AMI). Furthermore, in animal models CRP has been found to significantly increase infarct size. Read More

    Lipoprotein(a) is associated with left ventricular systolic dysfunction in a Chinese population of patients with hypertension and without coronary artery disease.
    Arch Med Sci 2017 Aug 12;13(5):1078-1085. Epub 2016 May 12.
    Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Introduction: Data on relationship between lipoprotein(a) (Lp(a)) and non-ischemic heart dysfunction are limited. This study is aimed to assess the association between Lp(a) and left ventricular systolic dysfunction in a Chinese population of patients with hypertension and without coronary artery disease (CAD).

    Material And Methods: This cross-sectional study included 1611 patients with hypertension and without CAD in China. Read More

    Interleukin-6 signaling in patients with chronic heart failure treated with cardiac resynchronization therapy.
    Arch Med Sci 2017 Aug 17;13(5):1069-1077. Epub 2016 Mar 17.
    Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
    Introduction: Increased expression of interleukin-6 (IL-6) has been described in left ventricular dysfunction in the course of chronic heart failure. Cardiac resynchronization therapy (CRT) is a unique treatment method that may reverse the course of chronic heart failure (CHF) with reduced ejection fraction (HF-REF). We aimed to evaluate the IL-6 system, including soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130), in HF-REF patients, with particular emphasis on CRT effects. Read More

    Effects of aspiration pneumonia on the intensive care requirements and in-hospital mortality of hospitalised patients with acute cerebrovascular disease.
    Arch Med Sci 2017 Aug 30;13(5):1062-1068. Epub 2016 Jun 30.
    Department of Biostatistics, Medical Faculty, Sakarya University, Sakarya, Turkey.
    Introduction: In this study, we aimed to evaluate the effects of the development of aspiration pneumonia (AP) on the intensive care unit (ICU) requirements and in-hospital mortality of patients hospitalised in the neurology ward due to an acute cerebrovascular accident (CVA).

    Material And Methods: Five hundred and three patients hospitalised in the neurology ward following an acute CVA were retrospectively analysed. The patients were divided into two groups: those with AP (group 1) and those without AP (group 2). Read More

    Prior transient ischemic attacks may have a neuroprotective effect in patients with ischemic stroke.
    Arch Med Sci 2017 Aug 17;13(5):1057-1061. Epub 2016 Nov 17.
    Department of Neurology, LiaoCheng Hospital, Liaocheng, China.
    Introduction: Although functional recovery and survival after ischemic infarction seem to improve in patients with prior transient ischemic attack (TIA), little is known about the role of characteristics of prior TIA in subsequent cerebral infarction. Thus, the objective of this study was to explore how the characteristics of prior TIA have a neuroprotective effect on patients with ischemic stroke.

    Material And Methods: A total of 221 patients admitted consecutively to a primary care center for first-ever ischemic stroke were divided into two groups on the basis of the presence or absence of prior TIAs. Read More

    The impact of hyperglycemia and hyperlipidemia on plasma P-selectin and platelet markers after ischemic stroke.
    Arch Med Sci 2017 Aug 1;13(5):1049-1056. Epub 2017 Feb 1.
    Department of Pathophysiology and Clinical Immunology, Medical University of Lodz, Lodz, Poland.
    Introduction: Platelet activation plays a key role in the pathogenesis of ischemic cerebrovascular diseases. Thus, it is very important to identify novel pharmacological targets for platelet inhibition to improve ischemic stroke treatment. The aim of the study was to assess the relationship between metabolic disorders and platelet activity markers in patients with acute ischemic stroke. Read More

    Cardiovascular diseases, metabolic syndrome and health behaviours of postmenopausal women working in agriculture.
    Arch Med Sci 2017 Aug 19;13(5):1040-1048. Epub 2017 Jul 19.
    Institute of Statistics and Demography, Warsaw School of Economics, Warsaw, Poland.
    Introduction: The objective of the study was to examine the impact of occurrence of cardiovascular diseases (CVDs) and metabolic syndrome (MS) diagnoses on the frequency of health behaviours in postmenopausal women working in agriculture.

    Material And Methods: Eight hundred and ten postmenopausal women living in rural areas and working in agriculture, aged 46-70 and at least 12 months from the last menstrual period, were examined. Analysis of variance with multiple comparison tests was used to compare the Inventory of Health Behaviours among the women with and without CVDs and MS. Read More

    Plasma soluble CD36, carotid intima-media thickness and cognitive function in patients with type 2 diabetes.
    Arch Med Sci 2017 Aug 22;13(5):1031-1039. Epub 2016 Jun 22.
    Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
    Introduction: Diabetes and atherosclerosis are both risk factors of cognitive deficits. Scavenger receptor CD36 is associated with increasing risk of diabetes and atherosclerosis, and may play a role in cognitive deficits. The aim of this study is to determine the correlations of plasma soluble CD36 concentrations with carotid intima-media thickness (IMT) and cognitive function in patients with type 2 diabetes. Read More

    Diabetes as a risk factor of hospitalization in the surgical ward due to cancer in the elderly and middle-aged population.
    Arch Med Sci 2017 Aug 22;13(5):1025-1030. Epub 2016 Mar 22.
    General Surgery Ward with Urology and Vascular Surgery Subdivisions, Specialist District Hospital, Stalowa Wola, Poland.
    Introduction: Diabetes can be considered as a risk factor of several types of malignancy. Surgery is one of the primary methods of cancer treatment. The objective of this study was to evaluate the association between diabetes and hospital admissions to the surgery unit due to malignancy among elderly and middle-aged people. Read More

    Antiplatelet and anticoagulant therapy in elderly people with type 2 diabetes mellitus in Poland (based on the PolSenior Study).
    Arch Med Sci 2017 Aug 17;13(5):1018-1024. Epub 2017 Jul 17.
    Department of Neurology in Zabrze, Medical University of Silesia, Katowice, Poland.
    Introduction: Type 2 diabetes mellitus (T2DM) is an important and common cardiovascular risk factor. The purpose of the study was to evaluate the frequency of use of oral antiplatelet drugs (OAPs) and oral anticoagulant drugs (OACs) among the elderly with T2DM in Poland.

    Material And Methods: The study was based on the data collected in the Polish national PolSenior study. Read More

    Modalities of ventricular pacing for cardiac resynchronization therapy in patients with heart failure: a meta-analysis and systematic review.
    Arch Med Sci 2017 Aug 31;13(5):1006-1017. Epub 2017 Jan 31.
    Department of Gastrointestinal Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
    Introduction: This meta-analysis evaluated 14 studies which compared clinical and functional outcomes after different cardiac resynchronization therapy (CRT) modalities.

    Material And Methods: Relevant studies were selected from the Medline, PubMed, Cochrane, and Google Scholar databases until June 27(th), 2016. We analyzed and compared the clinical outcomes (peak O2 consumption and LVEF) and functional outcomes (6-min walk distance and quality of life (SF-36)) of HF patients who received different CRT modalities with outcomes in patients who received conventional univentricular therapy. Read More

    Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
    Arch Med Sci 2017 Aug 4;13(5):965-1005. Epub 2017 Aug 4.
    Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland; Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group; Polish Lipid Association (PoLA).

    Additive effects of atorvastatin combined with sitagliptin on rats with myocardial infarction: a pilot study.
    Arch Med Sci 2017 Jun 12;13(4):956-961. Epub 2017 Jun 12.
    Department of Cardiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
    Introduction: Atorvastatin and sitagliptin are able to exert cardio-protective effects. However, whether atorvastatin plus sitagliptin could confer additive benefits for rats with myocardial infarction (MI) is unknown.

    Material And Methods: Forty rats with MI were produced and 37 surviving rats were randomly divided into atorvastatin (10 mg/kg daily, n = 9), sitagliptin (10 mg/kg daily, n = 9), combined (10 mg/kg daily atorvastatin plus 10 mg/kg daily sitagliptin, n = 9), and control groups (3 ml normal saline daily, n = 10). Read More

    The influence of rapamycin on the early cardioprotective effect of hypoxic preconditioning on cardiomyocytes.
    Arch Med Sci 2017 Jun 5;13(4):947-955. Epub 2016 May 5.
    Department of Anesthesiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
    Introduction: The purpose of this study was to examine the effects of rapamycin on the cardioprotective effect of hypoxic preconditioning (HPC) and on the mammalian target of rapamycin (mTOR)-mediated hypoxia-inducible factor 1 (HIF-1) signaling pathway.

    Material And Methods: Primary cardiomyocytes were isolated from rat pups and underwent rapamycin and/or HPC, followed by hypoxia/re-oxygenation (H/R) injury. Cell viability and cell injury were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays, and qRT-PCR was used to measure HIF-1α and mTOR mRNA expression. Read More

    Repeated positive acceleration exposure exacerbates endothelial dysfunction in high-fat-diet-induced hyperlipidemic rats.
    Arch Med Sci 2017 Jun 12;13(4):937-946. Epub 2017 Jun 12.
    Center of Clinical Aviation Medicine, General Hospital of PLA Air Force, Beijing, China.
    Introduction: It remains unclear whether exposure to repeated positive acceleration (+Gz) can exacerbate endothelial dysfunction on the basis of hyperlipidemia. The aim of this study was to investigate the effect of repeated +Gz exposure on endothelial function in high-fat-diet-induced hyperlipidemic rats.

    Material And Methods: Male Sprague-Dawley rats were randomly divided into control, repeat +Gz exposure, high-fat diet (HFD), and +Gz + HFD groups. Read More

    Genetic disruption of multidrug resistance-associated protein 1 improves endothelial function and attenuates atherosclerosis in MRP1(-/-) LDLr(-/-) double knockout mice.
    Arch Med Sci 2017 Jun 12;13(4):930-936. Epub 2017 Jun 12.
    Klinik II für Innere Medizin, Universität Bonn, Bonn, Germany.
    Introduction: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo. However, pharmacological inhibitors of MRP1 lack selectivity, which prompted us to study the in vivo impact of a genetic disruption of MRP1 on endothelial dysfunction, reactive oxygen species formation and atherogenesis in an atherosclerotic mouse model. Read More

    PCSK9 inhibitors - from discovery of a single mutation to a groundbreaking therapy of lipid disorders in one decade.
    Arch Med Sci 2017 Jun 19;13(4):914-929. Epub 2017 Jan 19.
    Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
    Hypercholesterolemia is one of the main risk factors for coronary heart disease and significantly contributes to the high mortality associated with cardiovascular diseases. Statin therapy represents the gold standard in the reduction of low-density lipoprotein cholesterol concentration. Nevertheless, many patients still cannot achieve the recommended target levels, due to either inadequate effectiveness or intolerance of these drugs. Read More

    Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3.
    Arch Med Sci 2017 Jun 22;13(4):897-913. Epub 2016 Mar 22.
    Nephrology Department, Dialysis and Renal Transplant Center, "C.I. Parhon" University Hospital, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e. Read More

    MicroRNAs and metabolic disorders - where are we heading?
    Arch Med Sci 2017 Jun 19;13(4):885-896. Epub 2017 Jan 19.
    Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
    MicroRNAs (miRNAs, miRs) are short, non-coding molecules engaged in normal functioning of eukaryotic cells, as negative regulators of gene expression. Since the first discovery of miRNA in the early 1990s, hundreds of different miRNAs and their targets have been identified. A growing number of studies have aimed to search for microRNAs which have a key role in the regulation of insulin signaling and metabolic homeostasis. Read More

    Obstructive sleep apnea and hormones - a novel insight.
    Arch Med Sci 2017 Jun 5;13(4):875-884. Epub 2016 Aug 5.
    Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznan, Poland.
    Obstructive sleep apnea (OSA), a disorder characterized by repetitive collapse of the upper respiratory tract during sleep, occurs in about 4% of middle-aged men and 2% of women. The incidence of the disorder is rising due to an increase in obesity and ageing of the population. Patients with obstructive sleep apnea are at elevated risk of some endocrinal and metabolic disorders, which may lead to serious consequences including shortening of life expectancy. Read More

    Clinical importance of epicardial adipose tissue.
    Arch Med Sci 2017 Jun 26;13(4):864-874. Epub 2016 Oct 26.
    MTA-SE Cardiovascular Imaging Research Group, Budapest, Hungary.
    Different visceral fat compartments have several systemic effects and may play a role in the development of both insulin resistance and cardiovascular diseases. In the last couple of years special attention has been paid to the epicardial adipose tissue (EAT), which can be quantified by non-invasive cardiac imaging techniques. The epicardial fat is a unique fat compartment between the myocardium and the visceral pericardium sharing a common embryologic origin with the visceral fat depot. Read More

    Obesity and inflammation: the linking mechanism and the complications.
    Arch Med Sci 2017 Jun 31;13(4):851-863. Epub 2016 Mar 31.
    Faculty of Public Health, Al Quds University of Gaza, Palestine.
    Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. Read More

    Fibroblast growth factor 23, iron and inflammation - are they related in early stages of chronic kidney disease?
    Arch Med Sci 2017 Jun 17;13(4):845-850. Epub 2016 Mar 17.
    2 Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.
    Introduction: Fibroblast growth factor 23 (FGF-23) levels are elevated in impaired renal function. Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney disease (CKD). Read More

    Clinical SYNTAX Score - a good predictor for renal artery stenosis in acute myocardial infarction patients: analysis from the REN-ACS trial.
    Arch Med Sci 2017 Jun 6;13(4):837-844. Epub 2016 Jun 6.
    Department of Nephrology, University of Medicine 'Gr. T. Popa', Iasi, Romania.
    Introduction: In ST-elevation myocardial infarction (STEMI) patients, multisite artery disease represents a serious issue influencing evolution, outcomes and prognosis. We evaluated for the first time the power of the Myocardial Infarction SYNTAX Score (MI SS) and Clinical SYNTAX Score (MI CSS) as predictors for renal artery stenosis (RAS) in STEMI. We also stratified the study population according to the two scores, and identified the variables correlated with the higher score. Read More

    Moderate-dose atorvastatin improves arterial endothelial function in patients with angina pectoris and normal coronary angiogram: a pilot study.
    Arch Med Sci 2017 Jun 12;13(4):827-836. Epub 2017 Jun 12.
    Centre for Preventive Cardiology, Department of Vascular Medicine, Division of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
    Introduction: Endothelial dysfunction could contribute to the pathophysiology of angina pectoris (AP) in patients with normal coronary angiograms. Besides lipid-lowering effects, statins exert pleiotropic effects including improving endothelial function.

    Material And Methods: Our double-blind study included 58 patients with AP, noninvasively confirmed myocardial ischemia and a normal coronary angiogram. Read More

    Phenotype distribution of the paraoxonase gene in patients with cardiac disease.
    Arch Med Sci 2017 Jun 25;13(4):820-826. Epub 2016 May 25.
    Department of Biochemistry, Tepecik Education and Research Hospital of Ministry of Health, Izmir, Turkey.
    Introduction: Paraoxonase (PON1) is an enigmatic enzyme with multiple enzymatic properties including arylesterase and lactonase activities besides its ability to hydrolyze the toxic metabolite of parathion, paraoxon. The aim of this study was to determine the phenotype distribution of PON1 in patients with cardiac disease who were classified in coronary artery bypass grafting (CABG), heart valve disease (HVD), heart failure (HF) and ST elevation myocardial infarction (STEMI) groups and healthy subjects as a control group.

    Material And Methods: A total of 300 people (100 cardiac surgery (70 CABG and 30 HVD), 70 HF, 30 STEMI patients and 100 healthy controls) were admitted to this study. Read More

    Apolipoprotein A1 polymorphisms and risk of coronary artery disease: a meta-analysis.
    Arch Med Sci 2017 Jun 19;13(4):813-819. Epub 2017 Jan 19.
    Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou, China.
    Introduction: It has been reported that APOA1 -75G/A polymorphism might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between APOA1-75G/A polymorphism and the risk of CAD.

    Material And Methods: A systematic search of studies on the association of single nucleotide polymorphisms (SNP) with susceptibility to CAD was conducted. Read More

    Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia.
    Arch Med Sci 2017 Jun 12;13(4):807-812. Epub 2017 Jun 12.
    Department of Cardiology, The First People's Hospital of Xianyang, Xianyang, Shanxi, China.
    Introduction: Dyslipidemia is associated with increased rho-associated kinase 2 (ROCK2) concentration. Whether moderate aerobic exercise could attenuate leukocyte ROCK2 concentration is unknown.

    Material And Methods: One hundred subjects with dyslipidemia and without statin treatment were enrolled and assigned to exercise and control groups. Read More

    The importance of two metabolic syndrome diagnostic criteria and body fat distribution in predicting clinical severity and prognosis of acute myocardial infarction.
    Arch Med Sci 2017 Jun 5;13(4):795-806. Epub 2016 May 5.
    Cardiac Catheterization Laboratory, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
    Introduction: The interrelation between metabolic syndrome (MetS) (the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF)) and obesity indices in predicting clinical severity and prognosis of acute ST-elevation myocardial infarction (STEMI) is insufficiently known.

    Material And Methods: This prospective study included 250 acute STEMI patients treated with primary percutaneous coronary intervention. The patients with/without MetS were analyzed by baseline (medical history, demography and obesity indices: overall - body mass index (BMI) vs. Read More

    The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome.
    Arch Med Sci 2017 Jun 31;13(4):785-794. Epub 2017 Jan 31.
    Department of Cardiology, Medical University of Lodz, Lodz, Poland.
    Introduction: The aim of this study was to evaluate the predictive value of selected adipokines in the improvement in the ejection fraction and in the development of adverse cardiac remodeling during 12 months of follow-up among patients with an ST-segment elevation acute myocardial infarction (STEMI) in the presence of metabolic syndrome (MeS).

    Material And Methods: The study population consisted of 69 patients (49 male; mean age: 59 ±10 years) with a first STEMI that was treated with a primary percutaneous coronary intervention (pPCI). In this group, 36 patients (18 male; mean age: 60 ±15 years) had MeS according to the definition of the International Diabetes Federation. Read More

    Increased plasma concentrations of interleukin 35 in patients with coronary artery disease.
    Arch Med Sci 2017 Jun 18;13(4):778-784. Epub 2016 Nov 18.
    Department of Internal Diseases and Clinical Pharmacology, Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Lodz, Poland.
    Introduction: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. Read More

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