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    gene and borderline hemoglobin Ain Saudi population.
    Arch Med Sci 2018 Jan 19;14(1):230-236. Epub 2017 Dec 19.
    Department of Biochemistry, University of Dammam, Dammam, Saudi Arabia.
    Introduction: Elevated HbA(hemoglobin A) level is considered the most reliable hematological parameter for the detection of β-thalassemia carriers. However, some carriers are difficult to recognize because the level of HbAis not in the distinctive carrier range, i.e. Read More

    Differential action of polyunsaturated fatty acids and eicosanoids on bleomycin-induced cytotoxicity to neuroblastoma cells and lymphocytes.
    Arch Med Sci 2018 Jan 19;14(1):207-229. Epub 2017 Dec 19.
    BioScience Research Centre, Gayatri Vidya Parishad College of Engineering Campus, Madhurawada, Andhra Pradesh, India.
    Introduction: This study was conducted to examine whether bleomycin-induced growth inhibitory action on human neuroblastoma cells (IMR-32) is influenced by anti-inflammatory metabolites of polyunsaturated fatty acids (PUFAs): lipoxin A4 (LXA4), resolvin D1 and protectin D1.

    Material And Methods: Thestudy was conducted using monolayer cultures of exponentially growing IMR-32 cells. The effects of various PUFAs and eicosanoids and anti-inflammatory metabolites of PUFAs such as lipoxin A4 (LXA4), resolvin D1 and protectin D1 on the growth of IMR-32 cells and human lymphocyteswere investigated. Read More

    Aerobic and concentration training and allele 7 in the dopamine receptor D4 () gene increase chances of smoking cessation in young Polish women.
    Arch Med Sci 2018 Jan 19;14(1):199-206. Epub 2017 Dec 19.
    Department of Dance Sciences, Poznan University of Physical Education, Poznan, Poland.
    Introduction: One reason for the limited effectiveness of the available smoking cessation methods is the fact that the causes of tobacco addiction have not been adequately explained yet. Numerous anti-smoking programs aimed at women involve intense physical activity. The goal of the study was to evaluate the effectiveness of health training for smoking cessation by young women in connection with the dopamine receptor gene () in their genetic profile. Read More

    How does the activity level of the parents influence their children's activity? The contemporary life in a world ruled by electronic devices.
    Arch Med Sci 2018 Jan 19;14(1):190-198. Epub 2017 Dec 19.
    Faculty of Health, School of Medicine, University Witten/Herdecke, Germany.
    Introduction: Apart from many positive changes associated with technical civilization, there are also - from the health point of view - some threats. The reduction in the level of physical activity is one of them. The aim of the study was to investigate whether there are any relationships between children's physical activity and behaviors, and to assess the impact of the adults' activity on their children's habits. Read More

    What does the Cantril Ladder measure in adolescence?
    Arch Med Sci 2018 Jan 20;14(1):182-189. Epub 2016 Jun 20.
    Department of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland.
    Introduction: The Cantril Scale (CS) is a simple visual scale which makes it possible to assess general life satisfaction. The result may depend on the health, living, and studying conditions, and quality of social relations. The objective of this study is to identify key factors influencing the CS score in Polish adolescents. Read More

    The validity of self-reported vs. measured body weight and height and the effect of self-perception.
    Arch Med Sci 2018 Jan 22;14(1):174-181. Epub 2016 Jul 22.
    Department of Public Health, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Introduction: The objective was to assess the validity of self-reported body weight and height and the possible influence of self-perception of body mass index (BMI) status on the actual BMI during the adolescent period.

    Material And Methods: This cross sectional study was conducted on 3918 high school students. Accurate BMI perception occurred when the student's self-perception of their BMI status did not differ from their actual BMI based on measured height and weight. Read More

    Persistence of primitive reflexes and associated motor problems in healthy preschool children.
    Arch Med Sci 2018 Jan 13;14(1):167-173. Epub 2016 Jun 13.
    Rehabilitation Developmental Laboratory, Department of Physiotherapy, Faculty of Health Sciences, Medical University of Wroclaw, Wroclaw, Poland.
    Introduction: Retained primitive reflexes can disturb natural development and involve difficulties in social and educational children's life. They can also impact on psychomotor development. Mature responses in a child's psychomotor progress can only occur if the central nervous system itself has reached maturity. Read More

    GABRG2 C588T gene polymorphisms might be a predictive genetic marker of febrile seizures and generalized recurrent seizures: a case-control study in a Romanian pediatric population.
    Arch Med Sci 2018 Jan 17;14(1):157-166. Epub 2016 Nov 17.
    Department of Cell and Molecular Biology, University of Medicine and Pharmacy of Târgu-Mureş, Târgu-Mureş, Romania.
    Introduction: This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein - GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) - in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures.

    Material And Methods: One hundred and fourteen children with idiopathic generalized epilepsy (group 1) or febrile seizures (group 2) were compared to 153 controls. Peripheral blood samples were assessed using polymerase chain reaction-restriction fragment length polymorphism analysis, with results interpreted based on the disappearance of a restriction site in the C allele (122 bp) compared to the T allele (100 bp + 22 bp). Read More

    Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?
    Arch Med Sci 2018 Jan 27;14(1):151-156. Epub 2016 Apr 27.
    Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
    Introduction: Dyshomeostasis of essential trace elements including iron and copper plays a key role in the pathogenesis of a myriad of serious conditions including iron deficiency (ID) anemia, in which impaired cellular energy metabolism is prominent. Although experimental studies documented decreased activity of cytochrome c oxidase (CytOx) in ID, there are not enough clinical data. The present study was conducted to determine serum copper levels and activity of mitochondrial CytOx in isolated lymphocytes of patients with iron deficiency. Read More

    The influence of various therapeutic regimens on early clinical and laboratory response and outcome of children with secondary hemophagocytic lymphohistiocytosis.
    Arch Med Sci 2018 Jan 4;14(1):138-150. Epub 2016 Mar 4.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Introduction: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening syndrome of severe hyperinflammation which is often triggered by infection or autoimmune disease (macrophage activation syndrome - MAS). The aim of our study was to assess the frequency of sHLH/MAS in children treated in our institution and to compare the effectiveness of various therapeutic interventions.

    Material And Methods: Between 2005 and 2013, 24 children (age: 1-17 years) were consecutively treated for sHLH/MAS. Read More

    Usefulness of molecular diagnosis in egg allergic children.
    Arch Med Sci 2018 Jan 23;14(1):132-137. Epub 2016 Mar 23.
    Department of Pediatrics, University of Chieti, Chieti, Italy.
    Introduction: Egg allergy is one of the most common food allergies in children. Egg white, including ovomucoid (OVM or Gal d 1) and ovalbumin (OVA or Gal d 2), is the major source of allergens. The aim of this study was to assess the role of Gal d 1 and Gal d 2 in predicting the risk of anaphylaxis caused by eggs in children, and to compare this new diagnostic tool with established methods of allergen-specific IgE detection. Read More

    Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis.
    Arch Med Sci 2018 Jan 29;14(1):122-131. Epub 2016 Aug 29.
    Departament of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital, Lodz, Poland.
    Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis.

    Material And Methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Read More

    Vitamin D deficiency is associated with urinary tract infection in children.
    Arch Med Sci 2018 Jan 26;14(1):115-121. Epub 2016 Oct 26.
    Department of Clinical and Chemical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt.
    Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) levels and the risk of first time febrile UTI in children.

    Material And Methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls. Read More

    Prognostic value of assessment of stool and serum IL-1β, IL-1ra and IL-6 concentrations in children with active and inactive ulcerative colitis.
    Arch Med Sci 2018 Jan 30;14(1):107-114. Epub 2017 Jun 30.
    Department of Pediatrics, Gastroenterology and Nutrition, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Interleukin-1β (IL-1β), interleukin-1 receptor antagonist (IL-1ra) and interleukin-6 (IL-6) contribute to the pathogenesis of ulcerative colitis (UC). The aim of our study was to evaluate the serum and stool IL-1β, IL-1ra and IL-6 concentrations as potential prognostic factors in children with UC.

    Material And Methods: Thirty-eight children with UC (20 active, 18 inactive) and 14 healthy controls were prospectively included in the study. Read More

    Enteric parasites can disturb leptin and adiponectin levels in children.
    Arch Med Sci 2018 Jan 20;14(1):101-106. Epub 2016 Jun 20.
    Department of Pediatrics, Children Hospital, Faculty of Medicine, Mansoura, Egypt.
    Introduction: Infection by intestinal parasites in childhood may be the main cause of many health-related problems in developed countries such as anemia, anorexia, loss of appetite, retarded growth and development. The aim of the present study was to assess the effect of different intestinal parasites on white adipose tissue hormones.

    Material And Methods: Eighty-one children infected by different parasites and 35 apparently healthy children were enrolled in this study. Read More

    Histologic recovery among children with celiac disease on a gluten-free diet. A long-term follow-up single-center experience.
    Arch Med Sci 2018 Jan 19;14(1):94-100. Epub 2017 Dec 19.
    First Pediatric Clinic, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    Introduction: Celiac disease (CD) is defined by gluten-induced immune-mediated enteropathy, affecting approximately 1% of the genetically predisposed population. The immunologic response to gluten causes characteristic intestinal alterations with gradual development. Histologic recovery of intestinal architecture was reported to occur within 6-12 months after starting a gluten-free diet, simultaneously with clinical remission. Read More

    Hydrogen excretion in pediatric lactose malabsorbers: relation to symptoms and the dose of lactose.
    Arch Med Sci 2018 Jan 20;14(1):88-93. Epub 2016 Jul 20.
    2 Department and Clinic of Pediatrics, Gastroenterology and Nutrition, Medical University of Wroclaw, Wroclaw, Poland.
    Introduction: Lactose malabsorption arises from lactase deficiency and may lead to lactose intolerance - gastrointestinal symptoms after lactose ingestion. Occurrence and severity of the symptoms are influenced by many factors, including the dose of lactose and the intensity of its colonic fermentation to short chain fatty acids and gases.

    Material And Methods: The hydrogen breath test (HBT) after 30 g or 50 g of lactose was performed in 387 children. Read More

    Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?
    Arch Med Sci 2018 Jan 6;14(1):81-87. Epub 2016 Sep 6.
    Laboratory of Clinical Chemistry and Microbiology, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
    Introduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). It is clear that obesity is one of the main risk factors involved in NAFLD pathogenesis, even if specific mechanisms have yet to be elucidated. We investigated the distribution of intestinal bifidobacteria and lactobacilli in the stools of four groups of children: obese, obese with NAFL, obese with NASH, and healthy, age-matched controls (CTRLs). Read More

    Diagnostic yield of esophagogastroduodenoscopy in children with chronic abdominal pain.
    Arch Med Sci 2018 Jan 31;14(1):74-80. Epub 2017 Jul 31.
    Department of Pathology, Kanuni Training and Research Hospital, Trabzon, Turkey.
    Introduction: Chronic abdominal pain (CAP) is one of the most common indications of esophagogastroduodenoscopy (EGD) in the pediatric population. However, there is not enough information about the diagnostic yield of EGD in children with CAP. We aimed to evaluate the diagnostic yield of EGD in children with CAP in the Eastern Black Sea region of Turkey. Read More

    Stool antigen detection versusC-urea breath test for non-invasive diagnosis of pediatricinfection in a limited resource setting.
    Arch Med Sci 2018 Jan 1;14(1):69-73. Epub 2016 Jul 1.
    Department of Clinical Pathology, Cairo University, Cairo, Egypt.
    Introduction: The prevalence of childhood infection withis high, especially in developing countries. Non-invasive methods for detection of infection in children should be inexpensive, easy to perform, well tolerated and have a high diagnostic accuracy. We aimed to compare the reliability, specificity and sensitivity of thestool antigen (HpSA) test with theC-urea breath test (C-UBT) for the diagnosis ofinfection in a limited resource setting. Read More

    Winter ambient training conditions are associated with increased bronchial hyperreactivity and with shifts in serum innate immunity proteins in young competitive speed skaters.
    Arch Med Sci 2018 Jan 19;14(1):60-68. Epub 2017 Dec 19.
    Department of Immunology, Rheumatology and Allergy, Healthy Ageing Research Centre, Medical University of Lodz, Lodz, Poland.
    Introduction: Regular training modulates airway inflammation and modifies susceptibility to respiratory infections. The impact of exercise and ambient conditions on airway hyperreactivity and innate immunity has not been well studied. We aimed to assess exercise-related symptoms, lung function, airway hyperresponsiveness and innate immunity proteins in relation to meteorological conditions and exercise load in competitive athletes. Read More

    Parental knowledge and metabolic control of children and young adults with type 1 diabetes.
    Arch Med Sci 2018 Jan 16;14(1):52-59. Epub 2016 Mar 16.
    Chair and Clinics of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.
    Introduction: The authors aimed to answer the following questions: 1) What level of knowledge of type 1 diabetes do the parents of children and young adults with this disease have? 2) Will this level of knowledge increase after 1 year of observation? 3) Does improving the knowledge of young adults and their parents result in better metabolic control of the patients?

    Material And Methods: This study included 227 patients between the ages of 5 and 20 years with type 1 diabetes. The research was conducted from March 2009 to June 2011. The following two time points were examined: the beginning of the study (test 1a) and one year later (test 1b). Read More

    An assessment of health status and health behaviours in adolescents: main points and methods of the SOPKARD-Junior programme.
    Arch Med Sci 2018 Jan 17;14(1):38-51. Epub 2016 Nov 17.
    Department of Preventive Medicine and Education, Medical University of Gdansk, Gdansk, Poland.
    Introduction: The study involved preparing and implementation a model of complex screening programme for adolescents and comparison of anthropometric examinations between the population of the SOPKARD-Junior programme and representative sample of Polish children in the same age.

    Material And Methods: The screening programme in 14-15 year old pupils (= 282) included: anthropometric, blood pressure, echocardiographic, electrocardiographic, carotid arteries, kidney and thyroid ultrasound examinations, as well as respiratory, dental and masticatory system, orthopaedic, psychological and psychiatric assessment. Blood and urine tests were also performed. Read More

    Relationship between urine lipid peroxidation, anthropometric parameters and parameters associated with goitre formation in school-age children.
    Arch Med Sci 2018 Jan 19;14(1):30-37. Epub 2017 Dec 19.
    Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
    Introduction: Oxidative stress has been implicated in the normal ageing process and the pathogenesis of several diseases, including goitre. The aim of the study was to evaluate the relationship between urine lipid peroxidation (LPO) and anthropometric parameters as well as the parameters associated with goitre formation in children.

    Material And Methods: The subjects included 172 healthy children (93 girls and 79 boys) aged 8-15, divided into 4 age groups - group I (8-9 years), group II (10-11 years), group III (12-13 years) and group IV (14-15 years) - and into 2 groups based on the BSA: the BSA-1 group (≤ 0. Read More

    Is there a rapid increase in prevalence of obesity in Polish children? An 18-year prospective observational study in Gdansk, Poland.
    Arch Med Sci 2018 Jan 19;14(1):22-29. Epub 2017 Dec 19.
    Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdansk, Poland.
    Introduction: The prevalence of overweight and obesity is not regularly screened among Polish children. Very few longitudinal data exist on the prevalence and increase of overweight and obesity in this population. The aim of the study was to analyze the prevalence of overweight and obesity among selected age categories of children from Gdansk, on the basis of 1992-2012 data. Read More

    Hypercholesterolaemia - practical information for non-specialists.
    Arch Med Sci 2018 Jan 19;14(1):1-21. Epub 2017 Dec 19.
    Cardiovascular Research Group, Faculty of Biology, Medicine & Health, University of Manchester, UK.
    Hypercholesterolaemia is amongst the most common conditions encountered in the medical profession. It remains one of the key modifiable cardiovascular risk factors and there have been recent advances in the risk stratification methods and treatment options available. In this review, we provide a background into hypercholesterolaemia for non-specialists and consider the merits of the different risk assessment tools available. Read More

    SOX10-MITF pathway activity in melanoma cells.
    Arch Med Sci 2017 Oct 17;13(6):1493-1503. Epub 2016 Jun 17.
    Department of Clinical Pharmacology and Pharmaceutical Care, Medical University of Warsaw, Warsaw, Poland.
    Melanoma is one of the most dangerous and lethal skin cancers, with a considerable metastatic potential and drug resistance. It involves a malignant transformation of melanocytes. The exact course of events in which melanocytes become melanoma cells remains unclear. Read More

    Care of cancer patients with liver and bone metastases - the place of pharmaceutical care in a balanced plan, focused on the patient's needs and goals.
    Arch Med Sci 2017 Oct 13;13(6):1483-1492. Epub 2016 Jun 13.
    Department of Pharmaceutica, Medical University of Silesia, Katowice, Poland.
    Metastatic cancer, especially in the growing population of geriatric patients, presents a big challenge to these patients, as well as to treatment teams and the entire health care system. This article describes some common medical problems faced by patients with metastases to liver and bone, and presents a diagnostic approach, and therapeutic management of various symptoms, relevant to advanced stages of the malignant disease. The article highlights the importance of patient education on various aspects of metastatic cancer, and underscores the unique position of pharmacists practicing pharmaceutical care, which is particularly beneficial in this group of patients with advanced malignancy. Read More

    Quality of life of patients from rural and urban areas in Poland with head and neck cancer treated with radiotherapy. A study of the influence of selected socio-demographic factors.
    Arch Med Sci 2017 Oct 31;13(6):1474-1482. Epub 2017 Oct 31.
    Institute of Public Health, Collegium Masoviensae, Lodz, Poland.
    Introduction: The quality of life (QoL) experienced by cancer patients depends both on their state of health and on sociodemographic factors. Tumours in the head and neck region have a particularly adverse effect on patients psychologically and on their social functioning.

    Material And Methods: The study involved 121 patients receiving radiotherapy treatment for head and neck cancers. Read More

    Survivin expression, HPV positivity and microvessel density in oropharyngeal carcinomas and relationship with survival time.
    Arch Med Sci 2017 Oct 27;13(6):1467-1473. Epub 2016 Apr 27.
    Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey.
    Introduction: Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis.

    Material And Methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Read More

    Pain, acceptance of illness, adjustment to life with cancer and coping strategies in prostate cancer patients.
    Arch Med Sci 2017 Oct 8;13(6):1459-1466. Epub 2016 Mar 8.
    Department of Public Health, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Prostate cancer is the second most common type of carcinoma in men. The rate of prostate cancer has increased approximately fivefold lover the last 30 years. The purpose of the study was to evaluate coping strategies, pain management, illness acceptance, and adjustment to cancer in patients diagnosed with prostate carcinoma and the effect of socioeconomic variables on the above-mentioned issues. Read More

    Updated analysis of vitamin D receptor gene FokI polymorphism and prostate cancer susceptibility.
    Arch Med Sci 2017 Oct 16;13(6):1449-1458. Epub 2016 Aug 16.
    Department of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu Province, China.
    Introduction: Polymorphisms of the vitamin D receptor (VDR) gene have been investigated in various case-control studies to evaluate prostate cancer susceptibility; however, published data on the association between vitamin D receptor gene FokI polymorphism and prostate cancer risk are inconclusive.

    Material And Methods: To assess the impact of vitamin D receptor gene FokI polymorphism, we performed a meta-analysis of eligible studies including 9,720 patients and 9,710 control subjects.

    Results: The overall results indicated no obvious association of this variant on prostate cancer risk. Read More

    Intensive rehabilitation as an independent determinant of better outcome in patients with lung tumors treated by thoracic surgery.
    Arch Med Sci 2017 Oct 20;13(6):1442-1448. Epub 2016 Jun 20.
    Department of Pulmonary Circulation and Thromboembolic Diseases, Centre of Postgraduate Medical Education, Otwock, Poland.
    Introduction: The frequency of postoperative complications after thoracic surgery remains high. Rehabilitation may become a procedure characterized by a high cost-effectiveness ratio. The aim of the study was to determine the independent importance of intensive rehabilitation in patients with lung tumors treated by thoracic surgery. Read More

    promoter methylation as a potential prognostic marker for acute leukemia.
    Arch Med Sci 2017 Oct 31;13(6):1433-1441. Epub 2017 Oct 31.
    Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland.
    Introduction: It has been proved that genetic and epigenetic changes play a significant role in the development and progression of acute leukemia. The aim of our study was to evaluate the frequency and prognostic implications of genetic and epigenetic alterations in,,andgenes in acute leukemias.

    Material And Methods: We included in the study 59 patients with acute leukemia. Read More

    Hindgut neuroendocrine neoplasms - characteristics and prognosis.
    Arch Med Sci 2017 Oct 6;13(6):1427-1432. Epub 2017 Jan 6.
    Department of Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: The aim of the study was to analyze the clinicopathologic characteristics and prognostic factors of hindgut-rectal neuroendocrine neoplasms.

    Material And Methods: The study included 38 patients with rectal neuroendocrine tumors who were treated at the Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland from February 2010 to December 2015. The clinicopathological data were retrospectively reviewed, extracted, analyzed, and patients were followed up to determine their survival status. Read More

    One-step nucleic acid amplification analysis of sentinel lymph nodes in papillary thyroid cancer patients.
    Arch Med Sci 2017 Oct 25;13(6):1416-1426. Epub 2017 Jan 25.
    Department of General and Oncological Surgery, Medical University of Lodz, Lodz, Poland.
    Introduction: It is essential to look for methods to define the need for central lymphadenectomy for papillary thyroid cancer patients. The aim is to determine the efficacy of one-step nucleic acid amplification (OSNA) and sentinel lymph node (SLN) biopsy in the intraoperative detection of nodal involvement.

    Material And Methods: This prospective, experimental study enrolled 49 patients with clinically negative lymph nodes. Read More

    Retrospective evaluation of histopathological examinations in invasive ductal breast cancer of no special type: an analysis of 691 patients.
    Arch Med Sci 2017 Oct 4;13(6):1408-1415. Epub 2016 Mar 4.
    Department of Pathomorphology, Military Institute of Medicine, Warsaw, Poland.
    Introduction: Invasive ductal carcinoma (IDC) is the most common type of breast cancer in women and accounts for about 80% of all breast cancers.

    Material And Methods: The material consisted of histological preparations derived from 691 patients treated for IDC-NST.

    Results: In our own study material, invasive ductal breast cancer of no special type accounted for more than 60% of cases, with the largest percentage of tumors being classified as G2 (53. Read More

    Application of artificial neural networks for predicting presence of non-sentinel lymph node metastases in breast cancer patients with positive sentinel lymph node biopsies.
    Arch Med Sci 2017 Oct 5;13(6):1399-1407. Epub 2016 May 5.
    Surgical Oncology Clinic, Collegium Medicum, Nicolaus Copernicus University, Oncology Center, Bydgoszcz, Poland.
    Introduction: The aim of this study was to present a new predictive tool for non-sentinel lymph node (nSLN) metastases.

    Material And Methods: One thousand five hundred eighty-three patients with early-stage breast cancer were subjected to sentinel lymph node biopsy (SLNB) between 2004 and 2012. Metastatic SLNs were found in 348 patients - the retrospective group. Read More

    Investigation of clinicopathological parameters in emergency colorectal cancer surgery: a study of 67 patients.
    Arch Med Sci 2017 Oct 20;13(6):1394-1398. Epub 2016 Jul 20.
    Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran.
    Introduction: The aim of the present study was to establish, having adjusted for case mix, the size of the differences in postoperative mortality and 5-year survival between patients presenting as an emergency with evidence of obstruction and perforation and the association of clinicopathological factors with mortality (bivariate analyses).

    Material And Methods: The study included 67 patients who presented with colorectal cancer (CRC) between 2009 and 2013 in Iran. The mean age of the patients was 59. Read More

    Sorafenib combined with hepatectomy in patients with intermediate-stage and advanced hepatocellular carcinoma.
    Arch Med Sci 2017 Oct 31;13(6):1383-1393. Epub 2017 Oct 31.
    Department of Hepatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    Introduction: Guidelines based on the Barcelona Clinic Liver Cancer (BCLC) classification system recommend that hepatic resection should be performed only in patients in BCLC stage A. Patients with stage B or stage C should receive palliative or no treatment. However, actual clinical practice varies, and a recent analysis of hepatocellular carcinoma (HCC) surgery outcomes in high volume surgical centers throughout the world concluded that hepatectomy can provide survival benefit for selected patients in all three BCLC stages. Read More

    Immunohistochemical features and staging of early gastric cancer.
    Arch Med Sci 2017 Oct 22;13(6):1373-1382. Epub 2016 Mar 22.
    University of Medicine and Pharmacy, Tirgu-Mureş, Romania.
    Introduction: The aim of this study was to analyze the particularities of early gastric cancer (EGC) and their importance for staging, prognosis, and therapy.

    Material And Methods: A total of 338 GCs diagnosed and surgically removed in three medical institutes from Eastern Europe were retrospectively examined, and the EGCs were further examined. Besides the demographic factors and tumor characteristics, immunostains were performed with E-cadherin, HER-2, p53, Ki67, MLH-1, MSH-2, COX-2, VEGF-A, CD31, and CD105. Read More

    Preoperative immunonutrition regulates tumor infiltrative lymphocytes and increases tumor angiogenesis in gastric cancer patients.
    Arch Med Sci 2017 Oct 19;13(6):1365-1372. Epub 2016 May 19.
    Department of General Surgery and Subspecialty (Gastrointestinal) Surgery, Faculty of Health Sciences, Istanbul Medeniyet University, Istanbul, Turkey.
    Introduction: An increased number of tumor infiltrative lymphocytes (TILs) is considered a favorable prognostic factor in various cancers because it is a marker of antitumoral activity of the immune system. In this prospective, non-randomized clinical trial, we evaluated the impact of preoperative immunonutrition on tumor infiltrative lymphocytes and neoangiogenesis in cancerous tissue in patients with locoregional and resectable gastric adenocarcinoma.

    Material And Methods: Patients with locoregional and resectable gastric adenocarcinoma were divided non-randomly into two study groups. Read More

    Stem cell factor in the serum of patients with esophageal cancer in relation to its histological types.
    Arch Med Sci 2017 Oct 9;13(6):1357-1364. Epub 2016 Aug 9.
    Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
    Introduction: Hematopoietic growth factors (HGFs), such as stem cell factor (SCF), may stimulate proliferation and differentiation of hematopoietic progenitor cells. Stem cell factor is also able to affect the growth of malignant tumors, including esophageal cancer (EC). The prognosis of EC patients' survival is still unfavorable. Read More

    Down-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma.
    Arch Med Sci 2017 Oct 20;13(6):1352-1356. Epub 2016 May 20.
    Department of Orthopedic Surgery, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
    Introduction: The aim of this study was to investigate the expression levels of microRNA-182 and microRNA-183 and their association with clinicopathological features in patients with osteosarcoma.

    Material And Methods: Total RNA was purified from samples and noncancerous bone tissues and then quantitative real-time polymerase chain reaction was applied to evaluate the expression levels of microRNAs, and their relationship with clinicopathological features and survival in osteosarcoma patients.

    Results: Our findings showed that expression of MiR-182 was clearly lower in osteosarcoma bone tissue (mean ± SD: 2. Read More

    Diagnostic investigations of PLA2G16 and CDH11 expression levels as independent prognostic markers of human osteosarcoma.
    Arch Med Sci 2017 Oct 5;13(6):1347-1351. Epub 2016 May 5.
    Department of Orthopedic and Traumatology, Universitätsklinikum Bonn, Bonn, Germany.
    Introduction: The aim of this study was to facilitate and deepen the understanding of the associations of the clinical significance of PLA2G16 and CDH11 in patients with osteosarcoma.

    Material And Methods: We collected 50 paired osteosarcoma tissues and adjacent normal bone tissues and evaluated the expression of PLA2G16 and CDH11 by quantitavise reverse transcriptase real-time polymerase chain reaction.

    Results: PLA2G16 expression was upregulated in osteosarcoma tissues when compared with adjacent normal bone tissues, and the difference was statistically significant (4. Read More

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