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    1493 results match your criteria Archives of medical science : AMS[Journal]

    1 OF 30

    The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention.
    Arch Med Sci 2018 Apr 23;14(3):701-706. Epub 2016 Mar 23.
    Department of Medicine, Unit of Internal Medicine and Hepatology, University Campus Bio-Medico, Rome, Italy.
    In recent years, close links between intestinal microbiota and host metabolism have been recognized. Intestinal bacteria can participate in the extraction of calories from food, and circulation of bacterial products, in particular lipopolysaccharides (LPS), is responsible for the "metabolic endotoxemia", which contributes to insulin resistance and its complications, such as non-alcoholic fatty liver disease (NAFLD). Indeed, qualitative and quantitative intestinal dysbiotic changes have been clearly documented in NAFLD patients, and several mechanisms by which the intestinal microbiota can directly promote liver fat deposition, inflammation and fibrosis have also been described. Read More

    The number of strata in propensity score stratification for a binary outcome.
    Arch Med Sci 2018 Apr 16;14(3):695-700. Epub 2016 Aug 16.
    School of Biology, University of St. Andrews, St. Andrews, Scotland, UK.
    Introduction: Non-interventional and other observational studies have become important in medical research. In such observational, non-randomized studies, groups usually differ in some baseline covariates. Propensity scores are increasingly being used in the statistical analysis of these studies. Read More

    Analysis of Web-based learning methods in emergency medicine: randomized controlled trial.
    Arch Med Sci 2018 Apr 4;14(3):687-694. Epub 2016 Mar 4.
    Helicopter Emergency Medical Service, Poland.
    Introduction: In medical education, Web-based learning is increasingly used as a complement to practical classes. The objective of the study was to perform a comparative analysis of three different forms of e-learning course on emergency medicine in terms of an indicator of knowledge growth and students' satisfaction.

    Material And Methods: For the purpose of the study, we developed and implemented a tool in the form of an online course: A - non-animated presentation, B - video, C - interactive video. Read More

    High lncRNA HULC expression is associated with poor prognosis and promotes tumor progression by regulating epithelial-mesenchymal transition in prostate cancer.
    Arch Med Sci 2018 Apr 27;14(3):679-686. Epub 2017 Jul 27.
    Department of Urologic Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan, China.
    Introduction: Recently, increasing evidence has shown that long non-coding RNAs (lncRNAs) play critical roles in tumor progression and development. However, the expression pattern and biological function of lncRNA HULC (highly upregulated in liver cancer) in prostate cancer (PCa) remain largely unclear.

    Material And Methods: The expression of lncRNA HULC in 53 paired PCa tissues and cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

    Indomethacin-induced gastric damage in rats and the protective effect of donkey milk.
    Arch Med Sci 2018 Apr 20;14(3):671-678. Epub 2016 May 20.
    Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey.
    Introduction: Indomethacin is an anti-inflammatory drug with clearly known side effects on gastric mucosa. New treatment and side effect prevention methods are being studied. Donkey milk, as a nutritional support, has recently come into the spotlight with its anti-oxidant features, high antibody content and low allergenic properties. Read More

    Ringer's lactate solution enhances the inflammatory response during fluid resuscitation of experimentally induced haemorrhagic shock in rats.
    Arch Med Sci 2018 Apr 5;14(3):655-670. Epub 2017 Sep 5.
    Department of General, Gastroenterological and Endocrine Surgery, Poznan University of Medical Science, Poznan, Poland.
    Introduction: Hemorrhagic shock leads to systemic oxygen deficit (hypoxaemia) that results in systemic inflammatory response syndrome (SIRS), a recognised cause of late mortality in this case. The aim of this study was to analyse the impact of fluid resuscitation, using two Ringer solutions, on the microcirculation changes that take place during experimentally induced haemorrhagic shock.

    Material And Methods: A model of the rat cremaster muscle was used to assess microcirculation . Read More

    The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats.
    Arch Med Sci 2018 Apr 6;14(3):645-654. Epub 2016 Jun 6.
    Department of Pharmacology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
    Introduction: We compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats.

    Material And Methods: Three groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were doubled in another set of study groups (K-60, T-30, and KTA groups, respectively). Read More

    Therapeutic inhibition of CXC chemokine receptor 2 by SB225002 attenuates LPS-induced acute lung injury in mice.
    Arch Med Sci 2018 Apr 6;14(3):635-644. Epub 2017 Jan 6.
    Department of Pediatric Cardiology, Shanghai Jiao Tong University Affiliated Shanghai Children's Medical Center, Shanghai, China.
    Introduction: Sustained neutrophilic infiltration is known to contribute to organ damage, such as acute lung injury (ALI). CXC chemokine receptor 2 (CXCR2) is the major receptor regulating inflammatory neutrophil recruitment in acute and chronic inflamed tissues. The purpose of this study was to investigate the functional relevance of the CXCR2 inhibitor SB225002 in LPS-induced acute lung injury. Read More

    Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.
    Arch Med Sci 2018 Apr 10;14(3):629-634. Epub 2017 Aug 10.
    Department of Cardiology, the First Affiliated Hospital of Sun Yat-sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China.
    Introduction: The effects of statins on lipoprotein-associated phospholipase A2 (Lp-PLA2) are controversial, and the present study aimed to investigate whether atorvastatin could reduce Lp-PLA2 in rats with dyslipidemia.

    Material And Methods: A high-fat and high-cholesterol diet was prescribed to produce a dyslipidemia model. Thereafter, low-dose atorvastatin (5 mg/kg/day), high-dose atorvastatin (20 mg/kg/day) or saline (without-treatment group) was prescribed for 14 days. Read More

    Sequencing of exons 4, 5, 12 of COCH gene in patients with postlingual sensorineural hearing loss accompanied by vestibular lesion.
    Arch Med Sci 2018 Apr 20;14(3):625-628. Epub 2016 May 20.
    Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics, Medical University of Lodz, Lodz, Poland.
    Introduction: Mutations at the DFNA9 locus on chromosome 14q12 are the third most common form of DFNA hearing loss, which is clinically characterized by late onset (in adulthood) progressive sensorineural hearing loss accompanied by vestibular dysfunction. The aim of the study was to search for COCH gene mutations (P51S, V66G, G87W, G88E, V104del, I109N, W117R, A119T, M512T, C542Y) in patients with severe or profound sensorineural hearing loss accompanied by a vestibular lesion.

    Material And Methods: The study was based on a group of 30 patients. Read More

    Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation.
    Arch Med Sci 2018 Apr 12;14(3):617-624. Epub 2016 May 12.
    Department of Orthopedics, Henan Provincial People's Hospital, Henan, China.
    Introduction: Osteoarthritis is an inflammatory disorder associated with oxidative stress and apoptosis leading to cartilage destruction and impairment of cartilage formation. In the present study, we studied the protective effect of lutein against monosodium iodoacetate (MIA)-induced osteoarthritis in primary chondrocyte cells.

    Material And Methods: Oxidative stress was determined through testing antioxidant status, reactive oxygen species levels and lipid peroxide content. Read More

    Effects of single and combined low frequency electromagnetic fields and simulated microgravity on gene expression of human mesenchymal stem cells during chondrogenesis.
    Arch Med Sci 2018 Apr 16;14(3):608-616. Epub 2016 May 16.
    Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, Ludwig-Maximilians-University, Munich, Germany.
    Introduction: Low frequency electromagnetic fields (LF-EMF) and simulated microgravity (SMG) have been observed to affect chondrogenesis. A controlled bioreactor system was developed to apply LF-EMF and SMG singly or combined during chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in 3D culture.

    Material And Methods: An external motor gear SMG bioreactor was combined with magnetic Helmholtz coils for EMF (5 mT; 15 Hz). Read More

    Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia.
    Arch Med Sci 2018 Apr 26;14(3):597-607. Epub 2016 Oct 26.
    Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
    Introduction: Inadequate trophoblast invasion and placentation are widely believed to contribute to preeclampsia, and multiple lines of evidence indicate the involvement of hypoxia in preeclampsia. However, the molecular mechanisms underlying the association of placental hypoxia with preeclampsia are not clear.

    Material And Methods: The present study focused on the role in preeclampsia of heme oxygenase 1 (HO-1), which is an inducible isoform of HO in response to hypoxia, via examining the expression of HO-1 and the expression and phosphorylation (Tyr705) of Signal transducer and activator of transcription (STAT) 3 in preeclamptic placentas via the immunohistochemical method, western blotting assay and RT-qPCR method. Read More

    MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1.
    Arch Med Sci 2018 Apr 30;14(3):588-596. Epub 2017 Jun 30.
    Department of Cardiothoracic Surgery, Xinxiang Central Hospital, Xinxiang, Henan, China.
    Introduction: Abnormal expression of microRNAs (miRNAs) contributes to cancer development through regulating proliferation, apoptosis and drug resistance in cancer cells. The present study was designed to explore the effect and mechanism of miR-141 on gastric cardia adenocarcinoma (GCA).

    Material And Methods: Forty-one paired GCA tissues and adjacent normal tissues were obtained from GCA patients never treated by chemotherapy or radiotherapy. Read More

    Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53.
    Arch Med Sci 2018 Apr 16;14(3):579-587. Epub 2018 Apr 16.
    Department of Pharmacology and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
    Introduction: Vascular smooth muscle cell (VSMC) proliferation plays a major role in the progression of vascular diseases. In the present study, we established the efficacy and the mechanisms of action of hinokitiol, a tropolone derivative found in , Cupressaceae, in relation to platelet-derived growth factor-BB (PDGF-BB) and serum-dependent VSMC proliferation.

    Material And Methods: Primary cultured rat VSMCs were pre-treated with hinokitiol and then stimulated by PDGF-BB (10 ng/ml) or serum (10% fetal bovine serum). Read More

    Augmented reality in neurosurgery.
    Arch Med Sci 2018 Apr 22;14(3):572-578. Epub 2016 Mar 22.
    Department of Electrical Engineering and Information Systems, University of Pannonia, Veszprém, Hungary.
    Neurosurgery is a medical specialty that relies heavily on imaging. The use of computed tomography and magnetic resonance images during preoperative planning and intraoperative surgical navigation is vital to the success of the surgery and positive patient outcome. Augmented reality application in neurosurgery has the potential to revolutionize and change the way neurosurgeons plan and perform surgical procedures in the future. Read More

    Sequentiality of treatment in the rheumatoid arthritis drug programme in the years 2009-2014.
    Arch Med Sci 2018 Apr 31;14(3):569-571. Epub 2016 Mar 31.
    Department of Quality, Procedures and Medical Standards, Medical University of Lodz, Lodz, Poland.
    Approximately 1% of the population suffers from rheumatoid arthritis (RA) worldwide (0.45% in Poland). The therapy consists of the use of disease-modifying antirheumatic drugs (DMARDs). Read More

    Hepatitis C coinfection adversely affects the life expectancy of people living with HIV in northwestern Poland.
    Arch Med Sci 2018 Apr 23;14(3):554-559. Epub 2016 Mar 23.
    Department of Infectious, Tropical Diseases and Immune Deficiency, Pomeranian Medical University, Szczecin, Poland.
    Introduction: Hepatitis C (HCV) infection adversely affects survival among people living with HIV, increasing mortality risk due to liver-related causes. In Poland HCV is found among ~30% of HIV infected individuals, with only a small percentage successfully treated for this coinfection. This study aimed to analyze the HCV-associated influence on the life expectancy among HIV/HCV coinfected patients from northwestern Poland. Read More

    Suspected unexpected and other adverse reactions to antiretroviral drugs used as post-exposure prophylaxis of HIV infection - five-year experience from clinical practice.
    Arch Med Sci 2018 Apr 5;14(3):547-553. Epub 2016 May 5.
    Department for Adults' Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
    Introduction: With increased use of antiretroviral drugs (ARVs) in HIV uninfected persons, proper reporting on suspected unexpected serious adverse reactions (SUSARs) and continued insight into adverse drug reactions (ADRs) are needed for adequate information on safety of ARVs in such populations.

    Material And Methods: Medical documentation of persons receiving ARVs after non-occupational HIV exposure (non-occupational post-exposure prophylaxis - nPEP) during 5 successive years (2009-2013) was evaluated by two HIV physicians. Adverse drug reactions s and SUSARs were defined according to international standards. Read More

    Prevalence of bacteria and fungi in samples of cornea preservation fluid.
    Arch Med Sci 2018 Apr 31;14(3):541-546. Epub 2016 Mar 31.
    Department of Dental Microbiology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Recipients of corneal transplants are at risk of healthcare-associated infections, which, apart from other causes of surgical site infections, may also occur as a result of the transfer of infected corneal tissue. In this study we assessed the risk of bacterial and fungal infections based on the results of routine microbiological testing of cornea preservation fluid samples.

    Material And Methods: We examined a total of 725 samples of corneal preservation fluid, obtained during a period of 3 years (2011-2013). Read More

    Radiographic features of anatomic relationship between impacted third molar and inferior alveolar canal on coronal CBCT images: risk factors for nerve injury after tooth extraction.
    Arch Med Sci 2018 Apr 23;14(3):532-540. Epub 2016 Mar 23.
    Department of Oral and Maxillofacial Surgery, Nanjing Medical University, Nanjing, China.
    Introduction: The present study was aimed to identify the radiographic signs between impacted third molar root and inferior alveolar canal (IAC) on cone-beam CT (CBCT) images as risk factors and prognostic predictors associated with inferior alveolar nerve (IAN) damage following tooth removal.

    Material And Methods: A retrospective clinical study was performed involving 136 patients with 257 impacted lower third molars from January 2013 to December 2014. The neurosensory function of the lower lip and chin was subjectively evaluated and assessed by neurosensory tests before and after surgery. Read More

    Decline in ovarian reserve may be an undiagnosed reason for unexplained infertility: a cohort study.
    Arch Med Sci 2018 Apr 23;14(3):527-531. Epub 2016 Mar 23.
    Department of Gynecology and Obstetrics, Katip Celebi University Faculty of Medicine, Ataturk Research and Training Hospital, Izmir, Turkey.
    Introduction: Unexplained infertility refers to the absence of a definable cause for a couple's failure to achieve pregnancy. Reproductive aging plays a role in pathogenesis of unexplained infertility. We investigated the results of ovarian reserve tests in unexplained infertility. Read More

    Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism.
    Arch Med Sci 2018 Apr 23;14(3):521-526. Epub 2016 Mar 23.
    Department of Endocrinology, Faculty of Medicine, Hitit University, Corum, Turkey.
    Introduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. Read More

    Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease.
    Arch Med Sci 2018 Apr 23;14(3):516-520. Epub 2016 Mar 23.
    Leumit Health Fund, Israel.
    Introduction: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20-25%, and that of celiac antibodies is 2-5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. Read More

    Mortality of adult intensive care units in Turkey using the APACHE II and SOFA systems (outcome assessment in Turkish intensive care units).
    Arch Med Sci 2018 Apr 5;14(3):510-515. Epub 2016 May 5.
    Medical Biostatistics Department, Faculty of Medicine, University of Ankara, Ankara, Turkey.
    Introduction: The aim of this study was to evaluate intensive care unit (ICU) performance using risk-adjusted ICU mortality rates nationally, assessing patients who died or had been discharged from the ICU. For this purpose, this study analyzed the Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) databases, containing detailed clinical and physiological information and mortality of mixed critically ill patients in a medical ICU at secondary and tertiary referral ICUs in Turkey.

    Material And Methods: A total of 690 adult intensive care units in Turkey were included in the study. Read More

    Risk factors and prognostic role of an electrical storm in patients after myocardial infarction with an implanted ICD for secondary prevention.
    Arch Med Sci 2018 Apr 5;14(3):500-509. Epub 2016 May 5.
    First Department of Cardiology, Medical University of Silesia, Katowice, Poland.
    Introduction: The aim of our study was to determine the risk factors for electrical storm (ES) and to assess the impact of ES on the long-term prognosis in patients after myocardial infarction (MI) with an implantable cardioverter-defibrillator (ICD) for secondary prevention of sudden cardiac death (SCD).

    Material And Methods: We retrospectively analyzed 416 patients with coronary artery disease after MI who had an implanted ICD for secondary prevention of SCD. Fifty (12%) patients had one or more incidents of an electrical storm - the ES (+) group. Read More

    Left ventricular structural and functional changes evaluated by echocardiography and two-dimensional strain in patients with sickle cell disease.
    Arch Med Sci 2018 Apr 23;14(3):493-499. Epub 2016 Mar 23.
    Post-graduate Program in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Introduction: Patients with sickle cell disease have increased left ventricular size, which is not usually accompanied by changes in systolic function indexes. We assessed echocardiographic abnormalities present in patients with sickle cell anemia (SCA) and compared echocardiographic parameters to other sickle cell diseases (OSCD).

    Material And Methods: A blind cross-sectional study with 60 patients with SCA and 16 patients with OSCD who underwent transthoracic echocardiography was performed. Read More

    Utility and safety of three-dimensional contrast low-dose dobutamine echocardiography in the evaluation of myocardial viability early after an acute myocardial infarction.
    Arch Med Sci 2018 Apr 17;14(3):488-492. Epub 2016 Mar 17.
    First Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: The aim of the study was to determine the utility and safety of three-dimensional contrast low-dose dobutamine echocardiography (3DCLDDE) in the evaluation of myocardial viability early after ST-elevation myocardial infarction (STEMI).

    Material And Methods: We prospectively evaluated a group of 100 consecutive patients. Myocardial viability was assessed using dobutamine echocardiography in 76 patients with segmental wall motion abnormalities, including 37 patients evaluated using 3DCLDDE and 39 patients evaluated using a standard low-dose dobutamine echocardiography protocol (LDDE), alternately. Read More

    Skin perfusion pressure for the prediction of wound healing in critical limb ischemia: a meta-analysis.
    Arch Med Sci 2018 Apr 8;14(3):481-487. Epub 2016 Sep 8.
    Department of Burns and Wound Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
    Introduction: The purpose of this meta-analysis was to determine the value and efficacy of skin perfusion pressure (SPP) for the prediction of wound healing in patients with critical limb ischemia.

    Material And Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched from inception until December 31, 2014 using combinations of the following keywords: skin perfusion pressure, limb ischemia, wound healing, prediction. Randomized controlled trials, 2-arm prospective studies, and retrospective studies that measured SPP in patients with limb ischemia were included. Read More

    Prophylaxis of medial compartment gonarthrosis in varus knee - current state of knowledge.
    Arch Med Sci 2018 Mar 29;14(2):454-459. Epub 2016 Mar 29.
    Department of Pediatric Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznan, Poland.
    The progression of gonarthrosis results in reduction of physical activity. One of the factors that increase the risk of osteoarthrosis may be joint overload related to the malalignment of the mechanical axis of the lower extremity. The medial compartment (MC) of the knee is particularly susceptible to overload due to the external knee adduction moment (EKAM). Read More

    Morphological and clinical aspects of the occurrence of accessory (multiple) renal arteries.
    Arch Med Sci 2018 Mar 17;14(2):442-453. Epub 2016 Mar 17.
    Department of Angiology, Interfaculty Chair of Anatomy and Histology, Medical University of Lodz, Lodz, Poland.
    Renal vascularization variants vastly differ between individuals due to the very complex embryogenesis of the kidneys. Moreover, each variant may have implications for clinical and surgical interventions. The number of operating procedures continues to grow, and includes renal transplants, aneurysmorrhaphy and other vascular reconstructions. Read More

    Natural approaches in metabolic syndrome management.
    Arch Med Sci 2018 Mar 19;14(2):422-441. Epub 2017 Jul 19.
    CGH Medical Center, Sterling, Illinois; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Metabolic syndrome (MetS) is characterized as a group of cardiometabolic risk factors that raise the risk for heart disease and other health problems, such as diabetes mellitus and stroke. Treatment strategies include pharmacologic interventions and supplementary (or "alternative") treatments. Nutraceuticals are derived from food sources (isolated nutrients, dietary supplements and herbal products) that are purported to provide health benefits, in addition to providing basic nutritional value. Read More

    Identification of toxic metals in human embryonic tissues.
    Arch Med Sci 2018 Mar 22;14(2):415-421. Epub 2015 Oct 22.
    Department of Mother's and Child's Health, Gynecologic and Obstetrical University Hospital, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: The cause of a significant number of miscarriages remains unexplained. There is a need to identify the potential role of environmental, dietary and lifestyle factors in the risk of pregnancy loss. The present study was the first to investigate the content of miscarried embryonic material with respect to eight metals (aluminium, cadmium, chromium, copper, manganese, nickel, lead and zinc). Read More

    Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency.
    Arch Med Sci 2018 Mar 21;14(2):407-414. Epub 2018 Feb 21.
    Department of Biology, Lund University, Lund, Sweden.
    Introduction: The standard therapy for exocrine pancreatic insufficiency (EPI) is porcine-derived pancreatic enzyme replacement therapy (PERT). In the present study we tested a new approach with a mixture of pancreatic-like enzymes of microbial origin (PLEM) in a 1-week efficacy study in EPI pigs. In addition to the conventionally used coefficient of fat and nitrogen absorption (CFA and CNA), parameters that more accurately reflect the nutritional and health status, such as changes in the lipemic index (LI), plasma triglyceride (TG) and non-esterified fatty acid (NEFA) levels, and somatic growth, were determined. Read More

    Preventive effects of total saponins of on fatty liver fibrosis in mice.
    Arch Med Sci 2018 Mar 26;14(2):396-406. Epub 2016 Oct 26.
    Medical College of China Three Gorges University, Yichang, China.
    Introduction: Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Fatty liver fibrosis, a severe form of NAFLD, is a key step which can be reversed by effective medical intervention. This paper aims to describe the protective role and mechanisms of action of total saponins of (SPJ) against fatty liver fibrosis in mice. Read More

    Age-related differences in function and structure of rat livers subjected to ischemia/reperfusion.
    Arch Med Sci 2018 Mar 21;14(2):388-395. Epub 2018 Feb 21.
    Department of Pharmacology, Wroclaw Medical University, Wroclaw, Poland.
    Introduction: Liver function is affected during ischemia/reperfusion (IR). The current state of knowledge about liver aging processes during IR is incomplete. We evaluated the effects of aging on liver structure and function under IR conditions. Read More

    The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study.
    Arch Med Sci 2018 Mar 30;14(2):381-387. Epub 2016 May 30.
    Department of Histology and Embryology, School of Medicine, Ankara University, Ankara, Turkey.
    Introduction: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy.

    Material And Methods: A total of 30 male Sprague-Dawley rats were divided into 3 groups. Read More

    The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation.
    Arch Med Sci 2018 Mar 18;14(2):370-380. Epub 2016 Nov 18.
    Department of Anaesthesiology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
    Introduction: The aim was to devise an animal model showing some of the neuropathological changes seen in senile dementia, and to investigate the effect of celastrol on cognition neuropathology in this model.

    Material And Methods: Forty male Sprague Dawley rats weighing 300-350 g were randomly divided into 5 groups ( = 8 each): control (Con); inhaled sevoflurane (Sev); diabetes mellitus (DM); diabetes mellitus + inhaled sevoflurane (DM/Sev); diabetes + inhaled sevoflurane + celastrol (Cel). Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ). Read More

    Expression of selected genes of dendritic and Treg cells in blood and skin of morphea patients treated with UVA1 phototherapy.
    Arch Med Sci 2018 Mar 21;14(2):361-369. Epub 2018 Feb 21.
    Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Morphea is a chronic autoimmune disease characterized by fibrosis of the skin. Dendritic cells (DC) and regulatory T cells (Tregs) play a significant role in development of autoimmune and tolerance mechanisms. The aim of the study was to establish the expression of selected genes of plasmacytoid and myeloid DC, Treg cells, and the microenvironment of cytokines (interleukin-17A (IL-17A), transforming growth factor β (TGF-β)) in blood and skin of morphea patients. Read More

    spp. co-infections in patients with skin changes and lymphadenopathy.
    Arch Med Sci 2018 Mar 13;14(2):357-360. Epub 2016 Jun 13.
    National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland.
    Introduction: Tularemia and spotted fever group rickettsioses (SFG) can be transmitted by ticks and have a number of common clinical symptoms. Most characteristic are a maculopapular or vesicular rash or an eschar at the site of the tick or insect bite accompanied by painful lymph nodes. The aim of this study was to determine whether spp. Read More

    The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on mite infection.
    Arch Med Sci 2018 Mar 17;14(2):353-356. Epub 2016 Jun 17.
    Department of Histology and Embryology, Biostructure Center, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Two human-specific species have been described: and . A medical condition caused by the presence of is called demodicosis.

    Material And Methods: The study material comprised eyelashes collected from 1499 patients. Read More

    Evaluation of the validity of treatment decisions based on surrogate country models before introduction of the Polish FRAX and recommendations in comparison to current practice.
    Arch Med Sci 2018 Mar 23;14(2):345-352. Epub 2016 Jun 23.
    Department of Orthopaedics and Traumatology of the Locomotor System, Baby Jesus Clinical Hospital, Warsaw, Poland.
    Introduction: Patients diagnosed before the Polish FRAX was introduced may require re-evaluation and treatment changes if the diagnosis was established according to a surrogate country FRAX score. The aim of the study was to evaluate the validity of treatment decisions based on the surrogate country model before introduction of the Polish FRAX and to provide recommendations based on the current practice.

    Material And Methods: We evaluated a group of 142 postmenopausal women (70. Read More

    Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results.
    Arch Med Sci 2018 Mar 21;14(2):336-344. Epub 2018 Feb 21.
    Health Sciences Faculty, Anahuac University, State of Mexico, Mexico.
    Introduction: Insufficient wound healing related to chronic inflammation of chronic venous leg ulcers (CVUs) represents an important public health problem. The aim of this study was to evaluate the effects of a carbohydrate polymer with zinc oxide therapy on CVUs.

    Material And Methods: Forty patients with CVUs were recruited for this study and were divided into a study group and control group. Read More

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