1,613 results match your criteria Archives of medical science : AMS[Journal]


Pulmonary hypertension in left heart disease.

Arch Med Sci 2019 Jan 17;15(1):262-273. Epub 2017 Jul 17.

Division of Cardiology, New York Medical College, Valhalla, NY, USA.

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http://dx.doi.org/10.5114/aoms.2017.68938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348356PMC
January 2019

Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes.

Arch Med Sci 2019 Jan 30;15(1):250-261. Epub 2018 Dec 30.

Hebei North University, Hebei, China.

Introduction: Exposure to the fine particulate matter PM2.5 is strongly associated with atherosclerotic diseases, creating considerable public concern. Nevertheless, the mechanisms have not been fully elucidated. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.81039
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http://dx.doi.org/10.5114/aoms.2018.81039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348359PMC
January 2019
4 Reads

administration of quercetin ameliorates sperm oxidative stress, inflammation, preserves sperm morphology and functions in streptozotocin-nicotinamide induced adult male diabetic rats.

Arch Med Sci 2019 Jan 30;15(1):240-249. Epub 2018 Dec 30.

Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Introduction: Diabetes mellitus (DM) has been associated with sperm damage. In view of the fact that quercetin possesses antioxidant and anti-inflammatory activities, this compound may help to protect sperm against damage in DM. In this study, effects of quercetin on sperm parameters in DM were investigated. Read More

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http://dx.doi.org/10.5114/aoms.2018.81038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348351PMC
January 2019

Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis.

Arch Med Sci 2019 Jan 23;15(1):232-239. Epub 2017 Jan 23.

Department of Surgery, Samsun State Hospital, Samsun, Turkey.

Introduction: Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress.

Material And Methods: Fifty-two adult male Sprague-Dawley rats were divided into four groups: sham + saline, sham + EP, ANP + saline, and ANP + EP. Read More

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http://dx.doi.org/10.5114/aoms.2017.65231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348362PMC
January 2019
1 Read

effect of methanolic extract on stress-induced gastric ulcers in rats.

Arch Med Sci 2019 Jan 19;15(1):223-231. Epub 2016 Oct 19.

Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Introduction: (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress.

Material And Methods: The methanolic extract of PS was prepared in the dose of 500 mg/kg. Read More

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http://dx.doi.org/10.5114/aoms.2016.63156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348366PMC
January 2019
3 Reads

BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice.

Arch Med Sci 2019 Jan 30;15(1):214-222. Epub 2018 Dec 30.

Department of Emergency, Xin Hua Hospital affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.

Introduction: Exercise training is a coadjuvant therapy in preventive cardiology, and it delays cardiac dysfunction and exercise intolerance in heart failure (HF). However, the mechanisms underlying muscle function improvement and cardioprotection are poorly understood. In this study, we tested whether exercise training would counteract skeletal muscle atrophy via activation of the BDNF pathway in myocardial infarction (MI)-induced HF mice. Read More

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http://dx.doi.org/10.5114/aoms.2018.81037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348347PMC
January 2019

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma.

Arch Med Sci 2019 Jan 2;15(1):204-213. Epub 2018 Mar 2.

Department of Oncology, Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Introduction: Histone deacetylase inhibitors (HDACIs) inhibit human osteosarcoma growth and cause apoptosis. Previously, we reported that HDACIs induce autophagy via the FOXO1 pathway. Whether there is involvement of autophagy in anti-osteosarcoma activity of HDACIs is still unknown. Read More

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http://dx.doi.org/10.5114/aoms.2018.73860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348367PMC
January 2019
1.890 Impact Factor

Stilbene glycoside protects osteoblasts against oxidative damage via Nrf2/HO-1 and NF-κB signaling pathways.

Arch Med Sci 2019 Jan 28;15(1):196-203. Epub 2018 Nov 28.

The First Department of Orthopedics Ward, First People's Hospital of Yuyao, Yuyao, Zhejiang, China.

Introduction: Oxidative stress is currently proposed as a risk factor associated with the development and progression of osteoporosis. Here, the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glycoside (THSG) on oxidative damage was investigated in an osteoblast-like MC3T3-E1 cell model.

Material And Methods: In this study, MC3T3-E1 cells were treated with hydrogen peroxide (HO) (100 µM) and THSG (20, 50 and 100 μM), and alkaline phosphatase (ALP). Read More

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http://dx.doi.org/10.5114/aoms.2018.79937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348355PMC
January 2019
1 Read

The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major.

Arch Med Sci 2019 Jan 30;15(1):191-195. Epub 2018 Dec 30.

Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey.

Introduction: Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major (β-TM) patients. The role of complement system in the etiopathogenesis of hemolysis observed in β-TM were released. Hemolysis induced by activation of complement system is prevented by complement regulatory proteins. Read More

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http://dx.doi.org/10.5114/aoms.2018.81036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348341PMC
January 2019
1 Read

Roles of miR-210 in the pathogenesis of pre-eclampsia.

Arch Med Sci 2019 Jan 2;15(1):183-190. Epub 2018 Feb 2.

Third Department of Obstetrical, Hebei Cangzhou Central Hospital, Hebei, China.

Introduction: This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia.

Material And Methods: A JAR cell line cultured in standard or hypoxic conditions was used in this study. Expression levels of miR-210 and PTPN2 were determined using real-time polymerase chain reaction (RT-PCR). Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.73129
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http://dx.doi.org/10.5114/aoms.2018.73129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348360PMC
January 2019
3 Reads

Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway.

Arch Med Sci 2019 Jan 8;15(1):174-182. Epub 2018 Nov 8.

Departments of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.

Introduction: Glycyrrhizinic acid is a natural product of pharmacological relevance and its anticancer activity against breast cancer cell lines has not been evaluated. Therefore the main purpose of the present study was to investigate the anticancer effects of glycyrrhizinic acid in MCF-7 human breast cancer cells.

Material And Methods: The MTT assay was used to evaluate the anticancer effects while a clonogenic assay was used to study its effects on colony formation tendency. Read More

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http://dx.doi.org/10.5114/aoms.2018.79429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348358PMC
January 2019
1 Read

FAM40A alters the cytoskeleton of podocytes in familial focal and segmental glomerulosclerosis by regulating F-actin and nephrin.

Arch Med Sci 2019 Jan 2;15(1):165-173. Epub 2018 Feb 2.

Division of Nephrology, Shanghai Changzheng Hospital of Second Military Medical University, Kidney Institute of Chinese People's Liberation Army, Shanghai, China.

Introduction: Familial focal and segmental glomerulosclerosis (FFSGS) was found in a large cohort of patients in our previous study. Under the sponsorship of the National Natural Science Foundation of China, we conducted linkage analysis and full exon sequencing on the genomes of 54 patients diagnosed with FFSGS. The results revealed a FAM40A gene signature in those patients. Read More

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http://dx.doi.org/10.5114/aoms.2018.73138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348344PMC
January 2019
2 Reads

Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3K/AKT/mTOR pathway.

Arch Med Sci 2019 Jan 8;15(1):152-164. Epub 2018 Mar 8.

Department of Neurology, the BaZhou People's Hospital of XinJiang Uygur Autonomous Region, XinJiang Uygur Autonomous Region, China.

Introduction: The renin-angiotensin system is associated with blood pressure regulation, inflammation, oxidative stress and insulin resistance. It can decrease intracellular oxidative stress. Stimulation with HO leads to increased oxidative stress and activation of the AKT/mTOR pathway. Read More

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http://dx.doi.org/10.5114/aoms.2018.74026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348342PMC
January 2019
1 Read

Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial.

Arch Med Sci 2019 Jan 2;15(1):146-151. Epub 2018 Jan 2.

Paliative Care Unit, Oncology Chair, Medical University of Lodz, Lodz, Poland.

Introduction: Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. Read More

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http://dx.doi.org/10.5114/aoms.2018.72566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348368PMC
January 2019

Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures.

Arch Med Sci 2019 Jan 17;15(1):141-145. Epub 2016 Oct 17.

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Science, Tehran, Iran.

Introduction: It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Read More

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http://dx.doi.org/10.5114/aoms.2016.63013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348352PMC
January 2019

Prevalence and clinical characteristics of rheumatoid arthritis in Poland: a nationwide study.

Arch Med Sci 2019 Jan 13;15(1):134-140. Epub 2017 Dec 13.

Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland.

Introduction: There are no reliable data regarding the prevalence of rheumatoid arthritis (RA) in Poland.

Material And Methods: The first stage was a face-to-face survey on a nationwide representative sample of 3000 people, which identified respondents with a physician-confirmed diagnosis of RA. The second stage was a survey of RA patients, which characterized the disease course and treatment. Read More

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http://dx.doi.org/10.5114/aoms.2017.71371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348369PMC
January 2019
1 Read

Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study.

Arch Med Sci 2019 Jan 12;15(1):126-133. Epub 2018 Feb 12.

Department of Psychiatry, The Second Affiliated Hospital Of Xinxiang Medical University, Henan Mental Hospital, Xinxiang, Henan, China.

Introduction: Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood.

Material And Methods: A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. Read More

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http://dx.doi.org/10.5114/aoms.2018.73422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348357PMC
January 2019

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches - a preliminary report.

Arch Med Sci 2019 Jan 2;15(1):120-125. Epub 2018 Mar 2.

Department of Paediatrics and Paediatric Endocrinology, School of Medicine, Medical University of Silesia, Katowice, Poland.

Introduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. Read More

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http://dx.doi.org/10.5114/aoms.2018.73983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348343PMC
January 2019

Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy.

Arch Med Sci 2019 Jan 10;15(1):113-119. Epub 2018 Jan 10.

Department of Obstetrics and Gynecology, Health Sciences University Zeynep Kamil Maternity and Children's Research Hospital, Istanbul, Turkey.

Introduction: Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases.

Material And Methods: A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Read More

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http://dx.doi.org/10.5114/aoms.2017.72424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348354PMC
January 2019
2 Reads

An evaluation of the usefulness of extracorporeal liver support techniques in patients with severe liver dysfunction.

Arch Med Sci 2019 Jan 25;15(1):99-112. Epub 2017 May 25.

Department of Anaesthesiology and Intensive Therapy - Centre for Artificial Extracorporeal Kidney and Liver Support, Dr Wł. Biegański Regional Specialist Hospital, Lodz, Poland.

Introduction: The mortality rate in patients with severe liver dysfunction with no option of transplantation is unacceptably high. The main aim of this study was to evaluate the usefulness of applying extracorporeal liver support (ECLS) techniques in this group of patients.

Material And Methods: Data from hospital admissions of 101 patients with severe liver dysfunction who were admitted to the department of Anaesthesiology and intensive therapy between 2006 and 2015 were retrospectively analysed. Read More

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http://dx.doi.org/10.5114/aoms.2017.67998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348365PMC
January 2019
1 Read

Oxidative stress markers in patients with hereditary angioedema.

Arch Med Sci 2019 01 31;15(1):92-98. Epub 2017 Jul 31.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Introduction: Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kinins may have dual beneficial and deleterious effects in vascular and inflammation physiopathology by inducing oxidative stress. We aimed to assess the serum concentrations of advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) in patients affected by HAE. Read More

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http://dx.doi.org/10.5114/aoms.2017.66160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348350PMC
January 2019
1 Read

Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus.

Arch Med Sci 2019 Jan 14;15(1):86-91. Epub 2018 Nov 14.

Endocrinology and Metabolic Diseases Division, Tekirdag State Hospital, Tekirdag, Turkey.

Introduction: Endocan and endoglin have been shown to play a role in angiogenesis. Aberrant excessive angiogenesis is a main factor in the development of diabetic nephropathy. In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them with healthy subjects. Read More

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http://dx.doi.org/10.5114/aoms.2018.79488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348346PMC
January 2019
1 Read

Direct results of a prospective randomized study comparing ablation with the nMARQ catheter and the PVAC catheter used with and without a 3D system (MAPER 3D Study).

Arch Med Sci 2019 Jan 30;15(1):78-85. Epub 2017 May 30.

1 Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Our aim was to compare in a prospective randomized study the safety, direct results and periprocedural data of ablation using an nMARQ catheter, a PVAC catheter used with the EnSite system, or a PVAC catheter only under fluoroscopy control.

Material And Methods: One hundred two patients (70 male, 57 ±11 years) with atrial fibrillation (AF) were prospectively randomized to: group 1 - ablation performed with an nMARQ catheter and the CARTO 3 system; group 2 - a PVAC catheter used with the EnSite system; group 3 - ablation with a PVAC catheter without a 3D system.

Results: Complete isolation of 400/402 pulmonary veins (PV) (99. Read More

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http://dx.doi.org/10.5114/aoms.2017.68054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348353PMC
January 2019
1 Read

Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention.

Arch Med Sci 2019 Jan 15;15(1):72-77. Epub 2016 Nov 15.

Department of Internal Diseases and Cardiological Rehabilitation, Medical University of Lodz, Lodz, Poland.

Introduction: Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients. The aim of this study was to assess the usefulness of suPAR in the prediction of adverse cardiac events in patients with first myocardial infarction (MI) undergoing primary percutaneous coronary intervention. Additionally, the diagnostic power of suPAR was assessed. Read More

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http://dx.doi.org/10.5114/aoms.2016.63596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348361PMC
January 2019
1 Read

Increased platelet reactivity in dyslipidemic patients with coronary artery disease on dual anti-platelet therapy.

Arch Med Sci 2019 Jan 30;15(1):65-71. Epub 2018 Dec 30.

3 Medical Department, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria.

Introduction: The optimal duration of dual anti-platelet therapy (DAPT) following percutaneous coronary intervention (PCI) is still a matter of debate. Biomarkers may help to identify patients who will benefit from extended DAPT. The aim of the study was to test the interaction between lipid parameters and platelet function in patients with coronary artery disease (CAD) on DAPT. Read More

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http://dx.doi.org/10.5114/aoms.2018.81035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348363PMC
January 2019
1.890 Impact Factor

IgG4-related disease in endocrine practice.

Arch Med Sci 2019 Jan 20;15(1):55-64. Epub 2017 Oct 20.

Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.

IgG4-related disease is a set of symptoms resulting from a chronic, usually multiple organ inflammatory condition which affects various organs. It consists of lymphoplasmacytic infiltrations with attendant fibrosis and deep vein thrombosis. Frequently observed tissue lesions are accompanied by elevated IgG4 levels in serum. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2017.70889
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http://dx.doi.org/10.5114/aoms.2017.70889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348348PMC
January 2019
13 Reads

Efficacy and safety of various anti-rheumatic treatments for patients with rheumatoid arthritis: a network meta-analysis.

Arch Med Sci 2019 Jan 30;15(1):33-54. Epub 2018 Dec 30.

The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Introduction: Biologics and traditional disease-modifying anti-rheumatic drugs (DMARDs) are generally used in treating patients with rheumatoid arthritis (RA). Previous studies have presented abundant data and information about the efficacy of such treatments, but the results were incomplete and inconclusive. This network meta-analysis was conducted to compare and assess the efficacy and safety of 15 therapies employing biologics and DMARDs for RA patients. Read More

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http://dx.doi.org/10.5114/aoms.2018.73714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348345PMC
January 2019

Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis.

Arch Med Sci 2019 Jan 31;15(1):23-32. Epub 2017 Jul 31.

Department of Medicine, Hangzhou Seventh People's Hospital, Zhejiang, China.

Introduction: Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we analyzed the efficacy and safety data from studies evaluating the efficacy of serotonin receptor agonists in patients with FD. Read More

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http://dx.doi.org/10.5114/aoms.2017.69234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348349PMC
January 2019

A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations.

Arch Med Sci 2019 Jan 30;15(1):12-22. Epub 2018 Dec 30.

Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.

Introduction: Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs).

Material And Methods: The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1 February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Read More

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http://dx.doi.org/10.5114/aoms.2018.81034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348364PMC
January 2019

Interventions to increase research publications in graduate medical education trainees: a systematic review.

Arch Med Sci 2019 Jan 30;15(1):1-11. Epub 2018 Dec 30.

Department of Medicine, Reading Hospital, Tower Health System, West Reading, PA, USA.

Introduction: Competency-based educational models recommend trainee exposure to research, but the best methods for Graduate Medical Education (GME) programs to accomplish this have not been clarified. The objective of this study was to quantify published interventions to generate resident research and compare effectiveness among those interventions.

Material And Methods: A systematic review of English-language articles of studies of GME programs was performed, describing resident research interventions and quantifying the number of publications as an outcome. Read More

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http://dx.doi.org/10.5114/aoms.2018.81033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348370PMC
January 2019

Connexin 43 expression in the testes during postnatal development of finasteride-treated male rat offspring.

Arch Med Sci 2018 Oct 15;14(6):1471-1479. Epub 2016 Nov 15.

Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland.

Introduction: Hormone-dependent events that occur throughout the first wave of spermatogenesis, such as cellular communication within seminiferous epithelium during early postnatal testis maturation, are important for adult male fertility. Any changes in the T/DHT ratio in male progeny born from females fertilized by finasteride-treated male rats can result in impairment of testicular physiology. The aim of the study was to verify whether finasteride has a transgenerational effect on the expression of connexin 43 (Cx43), a gap junction protein in testes of the F1 generation. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2016.63022
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http://dx.doi.org/10.5114/aoms.2016.63022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209711PMC
October 2018
4 Reads

Comparative effects of methylprednisolone and tetracosactide (ACTH) on ischemia/reperfusion injury of the rabbit spinal cord.

Arch Med Sci 2018 Oct 31;14(6):1459-1470. Epub 2017 Jan 31.

Neurosurgery Clinic, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health, Ankara, Turkey.

Introduction: Tetracosactide is an engineered peptide that applies the same biological impacts as the endogenous adrenocorticotropic hormone. Previous studies indicated that tetracosactide has anti-inflammatory, antioxidant and neurotrophic activity. In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2017.65650
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http://dx.doi.org/10.5114/aoms.2017.65650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209702PMC
October 2018
9 Reads
1.890 Impact Factor

Protective effect of nebivolol on doxorubicin-induced cardiotoxicity in rats.

Arch Med Sci 2018 Oct 23;14(6):1450-1458. Epub 2018 Oct 23.

Department of Cardiology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction: The cardiotoxicity of doxorubicin is incompletely understood. We investigated the prophylactic effect of nebivolol on doxorubicin-induced cardiac toxicity.

Material And Methods: Thirty rats were divided into a control group, doxorubicin-treated group and nebivolol + doxorubicin-treated group. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.79008
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http://dx.doi.org/10.5114/aoms.2018.79008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209710PMC
October 2018
11 Reads

Health needs as a priority of local authorities in Poland based on the example of implementation of health policy cancer programmes.

Arch Med Sci 2018 Oct 12;14(6):1439-1449. Epub 2016 Sep 12.

Department of Cancer Prevention, Medical University of Warsaw, Warsaw, Poland.

Introduction: In developed countries, malignant tumours are the second most common cause of death after cardiovascular diseases. The estimates made by epidemiologists indicate that the incidence and death rate for malignant tumours all over the world, Poland included, will probably grow in the decades to come, specifically among patients who are over 65. The aim of the study was to evaluate how local government units address the health needs of citizens on the basis of an analysis of health policy programmes concerning malignant tumours completed in Poland in 2009-2014. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2016.62283
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http://dx.doi.org/10.5114/aoms.2016.62283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209714PMC
October 2018
6 Reads

Comparison of unilateral pedicle screw fixation and interbody fusion with PEEK cage vs. standalone expandable fusion cage for the treatment of unilateral lumbar disc herniation.

Arch Med Sci 2018 Oct 6;14(6):1432-1438. Epub 2018 Apr 6.

Department of Orthopaedics, Zhoukou City Central Hospital, The Affiliated Hospital of Xinxiang Medical College, Zhoukou Shi, China.

Introduction: This study was conducted to compare the clinical effects of unilateral pedicle screw fixation and interbody fusion with PEEK cage (UPSFC) and standalone expandable fusion cage (SAEFC) on unilateral lumbar disc herniation.

Material And Methods: From September 2011 to July 2014, a respective investigation was performed on 130 lumbar disc herniation patients treated with SAEFC or UPSFC. The hospital stay, operating time, blood loss, Japanese orthopaedic association scores (JOA), and visual analogue score (VAS) in the two groups were compared using Student's -test. Read More

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http://dx.doi.org/10.5114/aoms.2018.74890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209698PMC
October 2018
2 Reads

Evaluation of implant fit and frontal plane alignment after bi-compartmental knee arthroplasty using patient-specific instruments and implants.

Arch Med Sci 2018 Oct 23;14(6):1424-1431. Epub 2018 Oct 23.

Department of Orthopaedic Surgery, König-Ludwig-Haus, Julius-Maximilians-University, Würzburg, Germany.

Introduction: The goals of successful bi-compartmental knee arthroplasty are to achieve correct fit and positioning of the implant, while appropriately correcting the mechanical alignment of the leg after surgery. As these requirements are not always reliably fulfilled using off-the-shelf implant systems, newer approaches for bi-compartmental resurfacing have been explored.

Material And Methods: In this article we report the radiographic results of 30 patients with anteromedial osteoarthritis (OA) who were treated with a novel patient-specific fixed-bearing bi-compartmental knee resurfacing system using custom-made implants and instruments. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.79007
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http://dx.doi.org/10.5114/aoms.2018.79007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209715PMC
October 2018
12 Reads

The significance of enzyme and transporter polymorphisms for imatinib plasma levels and achieving an optimal response in chronic myeloid leukemia patients.

Arch Med Sci 2018 Oct 15;14(6):1416-1423. Epub 2018 Feb 15.

4 Department of Internal Medicine and Hematology, Charles University, Faculty Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic.

Introduction: Imatinib mesylate is the drug of choice for patients with chronic myeloid leukemia (CML). Imatinib pharmacokinetics is affected by a number of transport proteins and enzymes.

Material And Methods: In the present study we evaluated the association of eight polymorphisms in the seven genes CYP3A5*3 (rs776746), CYP3A4*1 (rs2740574), CYP2C9*3 (rs1057910), SLC22A1 (rs683369), ABCB1 (rs1045642, rs1128503), ABCG2 (rs2231142) and ABCC2 (rs717620) with imatinib plasma level and achieving an optimal clinical response in 112 CML patients (53 men and 59 women). Read More

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http://dx.doi.org/10.5114/aoms.2018.73538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209720PMC
October 2018
10 Reads

A novel approach for preventing recurrence of malign pleural effusion: early phase pleurodesis.

Arch Med Sci 2018 Oct 4;14(6):1404-1415. Epub 2018 Jan 4.

Department of Thoracic Surgery, University of Yuzuncu Yil, Van, Turkey.

Introduction: The effective control of malignant pleural effusion (MPE) is of paramount importance in the treatment of patients with disseminated cancer. In this study, we compared two different approaches (early pleurodesis versus late pleurodesis) to MPE.

Material And Methods: Patients (188 cases) whose primary tumor type was known and who were confirmed to have MPE, were included in the study and were separated into two groups. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2017.72543
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http://dx.doi.org/10.5114/aoms.2017.72543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209722PMC
October 2018
11 Reads

High-normal thyroid-stimulating hormone in euthyroid subjects is associated with risk of mortality and composite disease endpoint only in women.

Arch Med Sci 2018 Oct 26;14(6):1394-1403. Epub 2016 Oct 26.

Department of Cardiology, Suruç State Hospital, Şanliurfa, Turkey.

Introduction: The aim of the study was to evaluate whether serum thyroid-stimulating hormone (TSH) within the normal range in euthyroid subjects (having normal free triiodothyronine (fT3) and thyroxine (fT4)) is related to the risk of overall mortality or a composite endpoint of death and nonfatal events.

Material And Methods: In 614 middle-aged adult hospital screenees, free of uncontrolled diabetes at baseline, the association of sex-specific TSH tertiles with death was prospectively assessed using Cox regression, with the composite endpoint assessed using logistic regression in adjusted analyses, stratified by gender.

Results: In total, 64 deaths and additional incident nonfatal events in 141 cases were recorded at a mean 7. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2016.63264
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http://dx.doi.org/10.5114/aoms.2016.63264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209708PMC
October 2018
9 Reads

3.0-T multiparametric magnetic resonance imaging modifies the template of endoscopic, conventional radical prostatectomy in all cancer risk categories
.

Arch Med Sci 2018 Oct 17;14(6):1387-1393. Epub 2018 Jul 17.

Urology Clinic, Centre of Postgraduate Medical Education, Department of Urology, European Health Centre - Otwock, Poland.

Introduction: We aimed to evaluate the diagnostic performance of 3.0-T multiparametric magnetic resonance imaging (mpMRI) in preoperative staging of prostate cancer (PCa) and its influence on the extent of resection during endoscopic radical prostatectomy (ERP) among cancer risk groups.

Material And Methods: The data of 154 patients with PCa in whom mpMRI was performed prior to ERP between 2011 and 2015 were included. Read More

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http://dx.doi.org/10.5114/aoms.2018.77222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209726PMC
October 2018
8 Reads

Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, N-acetyl-β-D-glucosaminidase levels and mortality risk in septic patients with acute kidney injury.

Arch Med Sci 2018 Oct 23;14(6):1381-1386. Epub 2018 Oct 23.

Department of Intensive Care Unit, Ningbo First Hospital, Ningbo, China.

Introduction: The aim of the study was to confirm whether higher levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and N-acetyl-β-D-glucosaminidase (NAG) are associated with mortality risk scores in severe septic patients with acute kidney injury (AKI).

Material And Methods: A prospective observational study was performed in an adult critical care unit. A total of 135 patients were included. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.79006
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http://dx.doi.org/10.5114/aoms.2018.79006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209703PMC
October 2018
8 Reads

Arterial stiffness is associated with target organ damage in subjects with pre-hypertension.

Arch Med Sci 2018 Oct 31;14(6):1374-1380. Epub 2017 Jul 31.

Department of Intensive Unit, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, China.

Introduction: Present study was to evaluate whether increased arterial stiffness was associated with target organ damage in pre-hypertensive subjects.

Material And Methods: Pre-hypertensive subjects enrolled and echocardiography was used to evaluate left ventricular hypertrophy (LVH) and the first morning urine was collected to evaluate albumin and creatinine ratio (ALB/Cr ratio). Carotid-femoral pulse wave velocity (cf-PWV) was measured. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2017.69240
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http://dx.doi.org/10.5114/aoms.2017.69240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209717PMC
October 2018
11 Reads

Association of common polymorphisms in the and genes with type 2 diabetes-related traits in Mexicans.

Arch Med Sci 2018 Oct 28;14(6):1361-1373. Epub 2018 Mar 28.

South Texas Diabetes and Obesity Institute (STDOI), School of Medicine, University of Texas Rio Grande Valley, Mexico, Mexico.

Introduction: Genetic variants have been replicated for association with type 2 diabetes mellitus (T2D) and many of them with diabetes-related traits. Because T2D is highly prevalent in Mexico, this study aimed to test the association of , , , and gene polymorphisms (rs10811661, rs8192678, rs2010963, rs7896005 and rs659366 respectively) with metabolic traits in 415 unrelated Mexican mestizos with T2D under three models of inheritance.

Material And Methods: A total of 415 unrelated Mexican mestizos were genotyped by TaqMan assays. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.74757
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http://dx.doi.org/10.5114/aoms.2018.74757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209716PMC
October 2018
8 Reads
1.890 Impact Factor

Is subclinical atherosclerosis associated with visceral fat and fatty liver in adolescents with type 1 diabetes?

Arch Med Sci 2018 Oct 12;14(6):1355-1360. Epub 2018 Mar 12.

Department of Medicine, Port Said University, Port Said, Egypt.

Introduction: There is a 3-fold higher prevalence of cardiovascular complications in patients with type 1 diabetes. The aim was to assess the relationship between subclinical atherosclerosis and visceral fat and fatty liver in diabetic adolescents.

Material And Methods: The study was performed on 110 adolescents with type 1 diabetes (T1D) attending the Pediatric Diabetes Clinic of the University Hospital, Ismailia, Egypt. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.74226
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http://dx.doi.org/10.5114/aoms.2018.74226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209700PMC
October 2018
10 Reads

Expression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems.

Arch Med Sci 2018 Oct 23;14(6):1348-1354. Epub 2018 Oct 23.

Department of Laboratory Medicine, Yancheng Health Vocational and Technical College, Yancheng, Jiangsu Province, China.

Introduction: Specific immunotherapy is critical for alleviating symptoms associated with house dust mite allergy, such as asthma and rhinitis. However, this approach relies on crude extracts, which are often not of sufficient quality or purity and are not standardized. The use of recombinant allergens may enable safer, more effective treatment. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.79005
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http://dx.doi.org/10.5114/aoms.2018.79005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209719PMC
October 2018
7 Reads
1.890 Impact Factor

Evaluation of the effects of pregabalin on chondrocyte proliferation and , α, and gene expression.

Arch Med Sci 2018 Oct 2;14(6):1340-1347. Epub 2018 Feb 2.

Department of Neurosurgery, School of Medicine, Namik Kemal University, Tekirdag, Turkey.

Introduction: The aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II (), hypoxia-inducible factor 1-α (α), and chondroadherin () gene expression in osteoarthritic chondrocytes.

Material And Methods: Standard primary chondrocyte cultures were prepared using osteochondral tissues that were surgically obtained from 6 patients with gonarthrosis. Cell morphology was evaluated using an inverted microscope, and cell death and proliferation were determined through MTT analysis, which was confirmed by AO/PI staining and statistically evaluated. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.73134
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http://dx.doi.org/10.5114/aoms.2018.73134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209709PMC
October 2018
6 Reads

Down-regulation of miR-203a by lncRNA PVT1 in multiple myeloma promotes cell proliferation.

Arch Med Sci 2018 Oct 8;14(6):1333-1339. Epub 2018 Mar 8.

Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.

Introduction: Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play vital roles in multiple myeloma (MM) development and progression. However, the underlying mechanism of PVT1 in MM remains unclear.

Material And Methods: QRT-PCR was used to detect the expression of PVT1 and miR-203a in MM samples and cell lines. Read More

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http://dx.doi.org/10.5114/aoms.2018.73975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209721PMC
October 2018
15 Reads

MiR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating .

Arch Med Sci 2018 Oct 31;14(6):1321-1332. Epub 2017 Dec 31.

Department of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Introduction: Pancreatic cancer is a highly lethal malignancy with high invasion metastasis, which is difficult to diagnose and treat. MicroRNA-216b (miR-216b) plays an important role in many types of tumors. In this study, we explore how miR-216b affected human pancreatic cancer cell development by targeting . Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.72564
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http://dx.doi.org/10.5114/aoms.2018.72564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209705PMC
October 2018
8 Reads
1.890 Impact Factor

The function and clinical relevance of lncRNA UBE2CP3-001 in human gliomas.

Arch Med Sci 2018 Oct 23;14(6):1308-1320. Epub 2018 Oct 23.

Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China.

Introduction: Gliomas are the most frequent primary tumors in the human brain. Recent studies have identified a class of long noncoding RNAs, named lncRNAs, which were reported to participate in regulating the development of various diseases, including gliomas. In our previous studies, we found that lncRNA UBE2CP3-001 was overexpressed in gliomas but not in normal tissue. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.79004
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http://dx.doi.org/10.5114/aoms.2018.79004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209712PMC
October 2018
9 Reads

Efficacy of brain radiotherapy plus EGFR-TKI for EGFR-mutated non-small cell lung cancer patients who develop brain metastasis.

Arch Med Sci 2018 Oct 23;14(6):1298-1307. Epub 2018 Oct 23.

Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, China.

Introduction: To analyze the appropriate treatment methods or timing to use epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and brain radiation treatment (RT) for symptomatic and asymptomatic brain metastases (BM) in patients with EGFR mutation non-small cell lung cancer (NSCLC).

Material And Methods: We retrospectively studied patients diagnosed with EGFR gene mutated NSCLC who developed brain metastasis between June 2006 and December 2015 at Zhejiang Cancer Hospital. Treatment data were assessed in 181 patients with 49 symptomatic BM and 132 asymptomatic BM retrospectively. Read More

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https://www.termedia.pl/doi/10.5114/aoms.2018.78939
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http://dx.doi.org/10.5114/aoms.2018.78939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209704PMC
October 2018
7 Reads