2,918 results match your criteria Archives of medical research[Journal]


High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis.

Arch Med Res 2018 Oct;49(7):504-511

Unidad de Investigación Médica en Inmunoquímica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Dr. Bernardo Sepúlveda Gutiérrez, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México; Servicio de Cirugía Gastrointestinal, Unidad Médica de Alta Especialidad, Hospital de Especialidades Dr. Bernardo Sepúlveda Gutiérrez, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Introduction: Cell damage in Acute Pancreatitis (AP) lead to release of cytokines and HMGB1 and Hsp70. While Hsp70 plays a role in cytoprotection, when released to extracellular milieu constitutes, as HMGB1, a danger signal and trigger pro-inflammatory responses. These molecules seem to be related to the clinical progression; but because no evidence exists about them as molecular network in AP development, we quantify HSP70, HMGB1, and cytokines in patients with AP and search for correlations with severity and prognosis. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.003DOI Listing
October 2018
1 Read

Downregulation of Adrenomedullin Leads to the Inhibition of the Tumorigenesis via VEGF Pathway in Human and Nude Mice Osteosarcoma Models.

Arch Med Res 2019 Mar 16. Epub 2019 Mar 16.

Department of Orthopaedics, The First Affiliated Hospital, Health Science Center, Xi'an Jiaotong University, Xi'an, China. Electronic address:

Background And Aims: Osteosarcoma is one of the most pernicious primary bone tumor characterized by high malignancy and metastasis, however its pathogenesis remain largely unknown. Our previous study showed elevated expression of adrenomedullin (ADM) is correlated with prognosis and disease severity in osteosarcoma patients. In this research, we continue to study the mechanisms of ADM-induced osteosarcoma cells proliferation in vitro and in vivo osteosarcoma models. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.03.002DOI Listing
March 2019
1 Read

Therapeutic Potential of Helminths and Helminth-Derived Antigens for Resolution of Inflammation in Inflammatory Bowel Disease.

Authors:
Amir Abdoli

Arch Med Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran; Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address:

Inflammation plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD), and treatment of IBD mainly targets on inhibition of pro-inflammatory mediators. Helminth-based therapy is a novel strategy for resolution of inflammation in IBD, because helminths have great immunomodulatory properties. Helminth-based therapy may be efficacious as a vaccine for patients with IBD. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.03.001DOI Listing
March 2019
1 Read

Association of APOE and CETP TaqIB Polymorphisms with Type 2 Diabetes Mellitus.

Arch Med Res 2018 Oct 7;49(7):479-485. Epub 2019 Mar 7.

Department of Clinical Chemistry, School of Allied Health Sciences, Walailak University, Thaiburi, Thasala, Nakhon Si Thammarat, Thailand. Electronic address:

Apolipoprotein E (APOE) and cholesteryl ester transfer protein (CETP) play an important role in the lipid metabolism. Dyslipidemia is one of the complications that found in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to investigate the association of APOE and CETP TaqIB polymorphisms with T2DM and its related metabolic parameters in Southern Thai population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183079
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http://dx.doi.org/10.1016/j.arcmed.2019.02.005DOI Listing
October 2018
5 Reads

Genotypes of Common Polymorphisms in the PON1 Gene Associated with Paraoxonase Activity as Cardiovascular Risk Factor.

Arch Med Res 2018 Oct 8;49(7):486-496. Epub 2019 Mar 8.

Laboratorio de Investigación en Epidemiología Clínica y Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, México. Electronic address:

Background: Paraoxonase-1(PON1) exhibits hydrolytic activity and prevents the oxidation of high and low-density lipoproteins. Polymorphisms in the PON1 gene have been associated with variations in paraoxonase activity and with the risk of coronary artery disease (CAD).

Aim Of The Study: This study analyzed the association between the frequencies of genotypes of the L55 M and Q192 R SNPs in the PON1 gene with the PON1 activity and with CAD risk factors. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.002DOI Listing
October 2018
1 Read

Response to: Chikungunya and Zika in Huila: Mapping their Incidence in a Neglected Area of Colombia.

Arch Med Res 2018 Oct 6;49(7):514. Epub 2019 Mar 6.

Facultad de Medicina, Universidad de Colima, Colima, Colima, México; Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Colima, Colima, México.

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http://dx.doi.org/10.1016/j.arcmed.2019.01.010DOI Listing
October 2018
1 Read

New Advances of Heparanase and Heparanase-2 in Human Diseases.

Authors:
Hao Jin Min Cui

Arch Med Res 2018 Oct 6;49(7):423-429. Epub 2019 Mar 6.

The Second Department of General Surgery, Zhuhai People's Hospital, No. 79 of Kangning Road, Xiangzhou District, Zhuhai City, Guangdong Province, China. Electronic address:

As we all know, heparanase plays an important role in human diseases. As a kind of endo-β-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically. HS is a vital component of extracellular matrix(ECM). Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.004DOI Listing
October 2018

Chikungunya and Zika in Huila: Mapping their Incidence in a Neglected Area of Colombia.

Arch Med Res 2018 Oct 21;49(7):512-513. Epub 2019 Feb 21.

Department of Internal Medicine, Hospital Universitario Hernando Moncaleano Perdomo, Universidad Surcolombiana, Neiva, Huila, Colombia.

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http://dx.doi.org/10.1016/j.arcmed.2019.01.009DOI Listing
October 2018

MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.

Arch Med Res 2018 Oct 18;49(7):471-478. Epub 2019 Feb 18.

Laboratorio de Genómica Funcional, Instituto Nacional de Medicina Genómica, Ciudad de México, México. Electronic address:

Background: MT4-MMP is a member of the metalloproteinases family, although with a controversial role in the extracellular matrix remodelation. Overexpression of this metalloproteinase has been observed in breast cancer and it has been suggested that it can regulate tumor growth and cancer progression. The mechanisms by which MT4-MMP participates in breast cancer includes tumor blood vessels desestabilization, the activation of an angiogenic switch, and increase of EGFR signaling. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.001DOI Listing
October 2018
2 Reads

Therapeutic Intranasal Vaccine HB-ATV-8 Prevents Atherogenesis and Non-alcoholic Fatty Liver Disease in a Pig Model of Atherosclerosis.

Arch Med Res 2018 Oct 18;49(7):456-470. Epub 2019 Feb 18.

Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address:

Background And Aims: Atherosclerosis as an inflammatory disease involved in the etiology of cardiovascular disease worldwide, in our days demands an array of different therapeutic approaches in order to soon be able to visualize an effective prevention. Based on an immunotherapeutic approach, we designed a non-invasive vaccine (HB-ATV-8), contained in a micellar nanoparticle composed of lipids and a peptide segment derived from the C-terminus of the cholesterol-ester transfer protein (CETP). Now we extend our successful proof of concept from the rabbit to a porcine model and investigated its effect in an attempt to undoubtedly establish the efficacy of vaccination in a model closer to the human. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.01.007DOI Listing
October 2018

Valproic Acid Induced Neurotoxicological Manifestations and its Mitigation by Melatonin in Rat Brain Synaptosomes.

Arch Med Res 2018 Oct 18;49(7):441-450. Epub 2019 Feb 18.

Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India. Electronic address:

Background And Aims: A short branched chain fatty acid, valproic acid (VPA), has been used worldwide for decades in the intervention of seizure disorders, neuropathic pain and migraine. However, several adverse effects of VPA have been reported over the years. The aim of our investigation was to evaluate the adverse effects of VPA on synaptic functions by using synaptosomal preparation of rat brain as an in vitro model and the possible protective role of melatonin against VPA induced neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.01.004DOI Listing
October 2018
1 Read

New and Future Parenteral Therapies for the Management of Lipid Disorders.

Arch Med Res 2018 Nov 8;49(8):538-547. Epub 2019 Feb 8.

Piedmont Heart Institute in Atlanta, Atlanta, GA, USA. Electronic address:

Cardiovascular disease (CVD) is the leading cause of death in the world. According to the World Health Organization, an estimated 17.9 million people died from CVD in 2016, representing 31% of all global deaths. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.01.001DOI Listing
November 2018

Arturo Zárate-Treviño.

Arch Med Res 2018 Oct 4;49(7):430-431. Epub 2019 Feb 4.

Head of National Research, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

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http://dx.doi.org/10.1016/j.arcmed.2019.01.006DOI Listing
October 2018

Cardiovascular Diseases: A Challenge for the New Era.

Arch Med Res 2018 Nov 2;49(8):515. Epub 2019 Feb 2.

Departamento de Cardiología, Hospital Universitario Santiago de Compostela, Santiago de Compostela, España.

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http://dx.doi.org/10.1016/j.arcmed.2019.01.003DOI Listing
November 2018

STEMI and NSTEMI: Real-world Study in Mexico (RENASCA).

Arch Med Res 2018 Nov 2;49(8):609-619. Epub 2019 Feb 2.

Unidad de Investigación y Educación en Salud Política, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction: Mexico is the country with the highest mortality due to acute myocardial infarction in adults older than 45 years old according to the OECD (28 vs. 7.5% of the average). Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.01.005DOI Listing
November 2018
6 Reads

Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Diabetic Patients and Its Association with Early Nephropathy.

Arch Med Res 2018 Oct 1;49(7):451-455. Epub 2019 Feb 1.

División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Delegación Jalisco, Instituto Mexicano del Seguro Social, Guadalajara, México. Electronic address:

Introduction: Diabetic nephropathy is a leading cause of chronic kidney disease (CKD). In diabetes, changes in serum levels of both soluble alpha Klotho (sKL) and fibroblast growth factor 23 (FGF-23) have been associated with CKD progression.

Objective: To evaluate the associations of circulating levels of sKL and FGF-23 with the presence of early nephropathy (EN) in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.01.008DOI Listing
October 2018
5 Reads

Thrombolysis Therapy in Specialized and Non-specialized Stroke Units.

Arch Med Res 2018 Nov 14;49(8):588-597. Epub 2019 Jan 14.

University of South Carolina, School of Medicine, Greenville, SC, USA. Electronic address:

Background: The benefits of a special stroke care unit (SSCU) over a non-specialized stroke care unit (NSSCU) is well documented in the literature. However, there are concerns that the benefits seen in the SSCU do not consider clinical risk factors that affect thrombolysis therapy.

Method: Retrospective data were collected from a stroke registry between January 1, 2010-June 30, 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183074
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http://dx.doi.org/10.1016/j.arcmed.2019.01.002DOI Listing
November 2018
8 Reads

Protein Kinase A as a Promising Target for Heart Failure Drug Development.

Arch Med Res 2018 Nov 11;49(8):530-537. Epub 2019 Jan 11.

Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA. Electronic address:

Heart failure (HF) is a clinical syndrome characterized by impaired ability of the heart to fill or eject blood. HF is rather prevalent and it represents the foremost reason of hospitalization in the United States. The costs linked to HF overrun those of all other causes of disabilities, and death in the United States and all over the developed as well as the developing countries which amplify the supreme significance of its prevention. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451668PMC
November 2018
2 Reads

Clostridium Difficile Infection: An Immunological Conundrum.

Arch Med Res 2018 Aug 4;49(6):359-364. Epub 2019 Jan 4.

División de Posgrado, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address:

The lack of comprehensive understanding of the way immunity backfires on incidence and complications has made Clostridium difficile infection (CDI), the infectious disease of our times, as evidenced by in the parallel course it follows along epidemic of chronic degenerative diseases. Within these ailments, if as suspected the main effect of Clostridium difficile A and B toxins depends on inflammation, then aberrant immune function due to antibiotics would explain IBD triggering after treatment but also, the higher incidence and mortality surrounding disorders that are inflammatory and/or that show abatement of neutrophils. This review will discuss severity of the disease in terms of challenges to immunity during the progression of acute illness. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.002DOI Listing

Innovative Strategies in Heart Failure: Present and Future.

Arch Med Res 2018 Nov 31;49(8):558-567. Epub 2018 Dec 31.

Departamento de Cardiología, Hospital Universitario Santiago de Compostela, Santiago de Compostela, España; Instituto para el Desarrollo e Integración de la Salud, Santiago de Compostela, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Madrid, España. Electronic address:

Heart failure (HF) is a progressively debilitating disease that considerably decreases the life expectancy and quality of life. It has become an important area of focus since it remains one of the most common reasons for admission in patients over the age of 65. Importantly, the incidence of HF has not declined within the past 20 years, but the survival after onset has increased in younger patients and men. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.011DOI Listing
November 2018
1 Read

Pathological Findings Observed in the Kidneys of Postnatal Male Rats Exposed to the 2100 MHz Electromagnetic Field.

Arch Med Res 2018 Oct 29;49(7):432-440. Epub 2018 Dec 29.

Department of Biochemistry, Recep Tayyip Erdogan University of Medical Faculty, Rize, Turkey.

Background: The widespread use by young people of modern communication devices such as mobile phones means that they are particularly exposed to electromagnetic fields (EMF) and other problems. However, few studies have researched the effects of long-term exposure to EMF in the kidney. We therefore investigated oxidative stress and apoptosis in long-term exposure to 2100 megahertz (MHz) in a rat model. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.010DOI Listing
October 2018

Overexpression of miRNA-143 Inhibits Colon Cancer Cell Proliferation by Inhibiting Glucose Uptake.

Arch Med Res 2018 Oct 27;49(7):497-503. Epub 2018 Dec 27.

Department of Colorectal Surgery, Cancer Hospital of China Medical University; Liaoning Cancer Hospital and Institute, Xiaoheyan Road, Dadong District, Shenyang City, Liaoning Province, P R China. Electronic address:

MiRNA-143 overexpression is related to upregulated blood glucose level in diabetic mice, and downregulated miRNA-143 has been observed in several types of cancers, indicating its role as a tumor suppression miRNA. Glucose metabolism plays pivotal roles in tumor growth. Therefore, miRNA-143 may target glucose metabolism to inhibit tumor growth. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.009DOI Listing
October 2018
1 Read
2.406 Impact Factor

Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis.

Arch Med Res 2018 Aug 27;49(6):391-398. Epub 2018 Dec 27.

Laboratorio de Desarrollo, Envejecimiento y Enfermedades Neurodegenerativas, División de Neurociencias, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system (CNS). Neuroinflammation and oxidative stress are involved in the pathogenesis of MS, promoting tissue damage and demielinization. Current research findings suggest that melatonin has antioxidant and neuroprotective effects. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.004DOI Listing

Clinical Use of Marijuana: The Thin Line Between Good and Evil?

Arch Med Res 2018 Aug 27;49(6):421-422. Epub 2018 Dec 27.

Universidad Católica de Cuenca, Provincia Azuay, República del Ecuador.

From centuries ago cannabis has been known as a botanic product with several properties, with medical use in the ancient world. Nowadays, it is recognized as the active component of marijuana, the drug with the highest rates of illicit use and abuse worldwide according to data provided by the World Health Organization. A huge debate has emerged in these past years with the growing interest to employ cannabis-based products with therapeutic purposes, a strategy that has increased in various European countries, Canada and more than half of the states that conform the United States, simultaneously with an important increase of flexibility in laws and regulations regarding the recreational use of this substance, especially in North America. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183079
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http://dx.doi.org/10.1016/j.arcmed.2018.12.003DOI Listing
August 2018
1 Read

Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure.

Arch Med Res 2018 Nov 21;49(8):583-587. Epub 2018 Dec 21.

Qilu Hospital of Shandong University, Jinan, Shandong, China.

Nicorandil, the first clinically applied ATP-sensitive K channel (KATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure and the potential mechanisms remain unclear. In this study, we investigated the effects of nicorandil on cardiac function, LV remodeling, and Bax expression in myocardium of LV in rats with ischemic heart failure. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.006DOI Listing
November 2018
3 Reads

Tryptase Promotes the Profibrotic Phenotype Transfer of Atrial Fibroblasts by PAR2 and PPARγ Pathway.

Arch Med Res 2018 Nov 21;49(8):568-575. Epub 2018 Dec 21.

Department of Cardiology, Tongji Hosipital of Tongji University, Shanghai, China. Electronic address:

Background: As shown in clinical and experimental studies, atrial fibrosis is an important mechanism for the occurrence and development of atrial fibrillation, the most common arrhythmia in the clinic with high disability and mortality. Some studies have shown the possible involvement of tryptase, a protease released by mast cells, in the fibrosis of heart tissues, but the effect and mechanism of tryptase on extracellular matrix (ECM) remodeling and atrial fibrosis is not clear yet.

Material And Method: This study evaluated the effects of tryptase on the proliferation, migration, ECM remodeling and the balance between matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) of fibroblasts by in vitro culture of atrial fibroblasts. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.002DOI Listing
November 2018
3 Reads

Sir William Osler's 'Influences' for the Successful Physician, A Reappraisal After 126 Years.

Arch Med Res 2018 Aug 19;49(6):418-420. Epub 2018 Dec 19.

Reta Lila Weston Institute of Neurological Studies, University College London, London, UK.

Background: The vertiginous pace with which modern medicine advances, can seem overwhelming to students and young doctors.

Aim Of The Study: To reappraise an oration by William Osler delivered to medical students at the point of their graduation.

Methods: Narrative review. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.008DOI Listing
August 2018
1 Read

Implementation of a Nationwide Strategy for the Prevention, Treatment, and Rehabilitation of Cardiovascular Disease "A Todo Corazón".

Arch Med Res 2018 Nov 20;49(8):598-608. Epub 2018 Dec 20.

Dirección de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The cardiovascular diseases (CVDs) have a growing impact over the world mortality, affecting mostly low and middle-income countries. This is due to changes in the population pyramid and the increase in unhealthy lifestyles that predispose the global population to cardiovascular risk factors such as overweight, obesity, smoking, hypertension, diabetes, dyslipidemias and metabolic syndrome. Ischemic heart disease and the cerebral vascular event remain the first causes of death reported by the World Health Organization (WHO) for more than a decade. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183086
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http://dx.doi.org/10.1016/j.arcmed.2018.12.007DOI Listing
November 2018
13 Reads

Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.

Arch Med Res 2018 Aug 17;49(6):381-390. Epub 2018 Dec 17.

Clinical Laboratory, First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi Province, China.

Objective: To investigate interaction between autophagy and PKC-ε in lipid metabolism of NAFLD cell models.

Methods: HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy. 3-MA was used to inhibit cell autophagy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183014
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http://dx.doi.org/10.1016/j.arcmed.2018.11.006DOI Listing
August 2018
12 Reads

Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review.

Arch Med Res 2018 Aug 17;49(6):405-417. Epub 2018 Dec 17.

Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland.

Background: Serum or plasma ferritin concentration is recommended by WHO as a biomarker to assess iron status in individuals and populations.

Methods: A systematic review was undertaken to summarise the evidence for ferritin reflecting iron status and to assess the cut-off points in different populations. Electronic databases were searched for studies evaluating ferritin concentrations compared against bone marrow aspirates for iron deficiency and to liver biopsies for risk of iron overload. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.12.005DOI Listing
August 2018
5 Reads

Ischemic Preconditioning Preserves Liver Energy Charge and Function on Hepatic Ischemia/Reperfusion Injury in Rats.

Arch Med Res 2018 Aug 13;49(6):373-380. Epub 2018 Dec 13.

División de Investigación Quirúrgica, Centro de Investigación Biomédica de Occidente, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México; Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Background: Cell energy during ischemia/reperfusion depends on mechanisms including adenosine diphosphate degradation, oxygen species and cytokine liberation, neutrophil infiltration, and endothelial dysfunction. Preconditioning-a brief ischemic episode that confers a state of protection against subsequent ischemia-reperfusion injury-involves NO and adenosine production, reduction in oxygen species liberation, and preservation of microcirculation. During hypoxia, constitutive NO production assures adequate oxygen delivery and reduced energy loss. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.004DOI Listing
August 2018
2 Reads

Lyme Neuroborreliosis is a Severe and Frequent Neurological Disease in Mexico.

Arch Med Res 2018 Aug 13;49(6):399-404. Epub 2018 Dec 13.

Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Unidad Médica de Alta Especialidad Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Objective: To describe clinical cases with neurological manifestations associated with Borrelia burgdorferi infection in a large cohort of children and adults from Mexico.

Material And Methods: Patients with neurological manifestation (cranial neuritis, radiculoneuritis, meningitis and encephalomyelitis) were recruited in one pediatric and two general hospitals, during January 2006-December 2015. Blood and cerebrospinal fluid (CSF) samples were drawn from each patient at inclusion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183035
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http://dx.doi.org/10.1016/j.arcmed.2018.11.007DOI Listing
August 2018
21 Reads

Metabolic Syndrome and Cardiovascular Disease: A Health Challenge.

Arch Med Res 2018 Nov 24;49(8):516-521. Epub 2018 Oct 24.

Western Diabetes Institute, Western University of Health Sciences, Pomona, California, USA.

Metabolic Syndrome (MetS) is a cluster of risk factors that, taken alone or synergically, are independent predictors of type 2 diabetes and cardiovascular disease (CVD), which are both major public health problems that requires urgent containment actions. Current controversies regarding MetS are focused on ascertain the unifying explanation of molecular and pathophysiological mechanisms originating the syndrome, involving insulin resistance and low-grade chronic inflammation. This review aims to present the clinical relevance of MetS and its complications, as well as the hypotheses addressing its etiopathogenic relation with CVD. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.003DOI Listing
November 2018

New Challenges for Hypertension Treatment.

Arch Med Res 2018 Nov 5;49(8):548-557. Epub 2018 Dec 5.

Programa "A todo corazón", Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

In Mexico around 22.3 million adult Mexicans have hypertension. An estimated 65 million adult Americans, or nearly one in four of the adult population of the United States, have hypertension. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.005DOI Listing
November 2018

High-accuracy Detection of Preoperative Thyroid Nodules Using Combination of BRAF Mutation and TMPRSS4 mRNA Level.

Arch Med Res 2018 Aug 3;49(6):365-372. Epub 2018 Dec 3.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background: Papillary thyroid cancer (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid cancers. Though the fine needle aspiration biopsy (FNAB) represents as the golden standard for the diagnostics of thyroid nodules, there is a ∼25% risk of indeterminate cytological features. TMPRSS4 is a newly found transmembrane serine protease which was overexpressed in papillary thyroid cancer (PTC). Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.003DOI Listing
August 2018
9 Reads
2.406 Impact Factor

Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.

Arch Med Res 2018 Jul 16;49(5):335-341. Epub 2018 Nov 16.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. Electronic address:

Background: Sphingosine kinase (SphK) is considered as a potential target for developing novel therapeutics of cancer and other diseases including diabetes. As the major SphK isoform in the liver, much less is known the role of SphK2 involved in regulating hepatic glucose metabolism.

Method: In this study, RNA interference, real time RT-PCR, western blot and immunoprecipitation method was used to investigate the regulation of SphK2 in hepatic glucose metabolism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183072
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http://dx.doi.org/10.1016/j.arcmed.2018.11.001DOI Listing
July 2018
11 Reads

Reduction of No Reflow with a Loading Dose of Atorvastatin before Primary Angioplasty in Patients with Acute ST Myocardial Infarction.

Arch Med Res 2018 Nov 13;49(8):620-629. Epub 2018 Nov 13.

Código Infarto, Hospital de Cardiología, Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Background: No reflow defined as an altered myocardial reperfusion and failure at microvascular level is a frequent complication in acute myocardial infarction that attenuates beneficial effect of reperfusion therapy leading to poor outcomes. There is not enough evidence to support that previous use of statins improves coronary flow in patients undergoing primary percutaneous coronary intervention (PCI).

Aim Of Study: To determine if a loading dose of 80 mg of atorvastatin before primary angioplasty reduces the frequency of no reflow, hs-CRP, IL6 intracoronary levels, and major combined cardiovascular events at 30 d. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.006DOI Listing
November 2018
8 Reads

Clinical Interest of Circulating Tumor DNA in Oncology.

Arch Med Res 2018 Jul 7;49(5):297-305. Epub 2018 Nov 7.

Université de Lorraine, CNRS UMR 7039 CRAN, Institut de Cancérologie de Lorraine, Service de Biopathologie, Nancy, France. Electronic address:

Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heterogeneity. In various body fluids like plasma, somatic mutations have been identified. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.007DOI Listing

Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway.

Arch Med Res 2018 Jul 5;49(5):314-322. Epub 2018 Nov 5.

College of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi, China. Electronic address:

Background: Hepatic gluconeogenesis plays an important role in regulating fasting plasma glucose levels and is a target of anti-diabetic drugs. Several kinds of iridoid glucosides exhibit hypoglycemic effect, whereas the mechanism was not clear.

Aim Of The Study: In this study, the effects of geniposide and gentiopicroside, two natural iridoid glucosides, on hepatic gluconeogenesis were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183023
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http://dx.doi.org/10.1016/j.arcmed.2018.10.005DOI Listing
July 2018
19 Reads

Predicting Human miRNA-like Sequences within Human Papillomavirus Genomes.

Arch Med Res 2018 Jul 3;49(5):323-334. Epub 2018 Nov 3.

Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Unidad Médica de Alta Especialidad, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Background: This study presents a prediction of putative miRNA within several Human Papillomavirus (HPV) types by using bioinformatics tools and a strategy based on sequence and structure alignment. Currently, little is known about HPV miRNAs.

Methods: Computational methods have been widely applied in the identification of novel miRNAs when analyzing genome sequences. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183070
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http://dx.doi.org/10.1016/j.arcmed.2018.10.008DOI Listing
July 2018
17 Reads

Antioxidant Activity and Protective Effect of Carob Honey in CCl-induced Kidney and Liver Injury.

Arch Med Res 2018 Jul 17;49(5):306-313. Epub 2018 Oct 17.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco.

Background/aim: Various honey samples exhibited protective effect against drug and chemical induced toxicity. The study was designed to determine the antioxidant content and activity of carob honey and to investigate its hepato-renal protective effect in carbon tetrachloride (CCl4) induced kidney and liver injury in rats.

Material And Methods: Phenolic, flavone and flavonol in carob honey were quantified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01884409183032
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http://dx.doi.org/10.1016/j.arcmed.2018.09.011DOI Listing
July 2018
24 Reads

Association Studies of HSPA1A and HSPA1L Gene Polymorphisms With Schizophrenia.

Arch Med Res 2018 Jul 17;49(5):342-349. Epub 2018 Oct 17.

Department of Medical Genetics, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.

Background: Schizophrenia is a severe psychiatric disorder with a strong genetic component. The HSP70 chaperones are particularly interesting in terms of schizophrenia, especially with regard to neurodevelopmental hypothesis, because they are critical regulators in normal neural physiological function as well as in cell stress responses.

Aim Of The Study: The present study aimed to determine whether genetic variants in the HSPA1A (rs1008438, rs562047) and HSPA1L (rs2075800) genes are associated with the risk of paranoid schizophrenia and the clinical presentation of the disease. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.002DOI Listing
July 2018
13 Reads

Varicella-Zoster Virus in Cerebrospinal Fluid at Relapses of Multiple Sclerosis is Infective in Vitro.

Arch Med Res 2018 Jul 17;49(5):350-355. Epub 2018 Oct 17.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México. Electronic address:

Background: We have reported the presence of varicella-zoster virus (VZV) DNA and viral particles in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation. It is not known whether these viruses are infective.

Aim: To determine whether the VZV found in CSF of MS patients in exacerbation phase are infective. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.001DOI Listing
July 2018
2 Reads

Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line.

Arch Med Res 2018 May 9;49(4):226-234. Epub 2018 Oct 9.

Department of Biosciences, Jamia Millia Islamia, New Delhi.

Aim Of The Study: Rutin and Silibinin are active flavonoid compounds, well-known for possessing multiple biological activities. We have studied how Rutin and Silibinin in combination modulate wide range intracellular signaling cascades as evidenced by in-vitro research. Data obtained from preclinical studies provide evidence to be supportive to bridge basic and translational studies. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.09.008DOI Listing
May 2018
19 Reads

Response to: Chikungunya in Bolivia: Still a Neglected Disease?

Arch Med Res 2018 May 9;49(4):289. Epub 2018 Oct 9.

Center for Health and the Global Environment, Harvard T.H. Chan School of Public Health, USA; Facultad de Ingeniería Civil, Universidad de Colima, Coquimatlán, Colima, México; T.H. Chan School of Public Health, Center for Health and the Global Environment, Harvard University, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arcmed.2018.09.003DOI Listing
May 2018
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Vaccination Status and Another Preventive Measures in Medical Schools. Big Needs and Opportunities.

Arch Med Res 2018 May 6;49(4):286-287. Epub 2018 Oct 6.

Member of the Advisory Board, Archives of Medical Research, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address:

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http://dx.doi.org/10.1016/j.arcmed.2018.09.010DOI Listing
May 2018
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Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder.

Arch Med Res 2018 May 3;49(4):261-269. Epub 2018 Oct 3.

College of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, China. Electronic address:

Background And Aims: The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings.

Materials/methods: To clarify such contradiction, a comprehensive meta-analysis was conducted by searching PubMed, EMBASE, Web of Science and China Knowledge Resource Integrated Database. Odd ratios (ORs) and 95% confidence intervals (Cis) were used to evaluate the strength of the association. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.08.010DOI Listing

Association Between miR-149 Gene rs2292832 Polymorphism and Risk of Gastric Cancer.

Arch Med Res 2018 May 28;49(4):270-277. Epub 2018 Sep 28.

Department of Oncology, Jinhua Central Hospital, Jinhua Hospital of Zhejiang University, East Renmin Road, Jinhua, Zhejiang, China. Electronic address:

Background And Aims: Accumulating evidence suggested that microRNA (miRNA) genes take part in different processes associated with gastric cancer (GC). The single nucleotide polymorphisms (SNPs) located on miRNA sequences may affect the interaction with their target mRNAs and consequently the genetic susceptibility to GC.

Materials/methods: A hospital-based case-control study with 320 cases and 354 controls was conducted to investigate the association between miR-149 gene rs2292832 polymorphism and GC susceptibility in a Chinese Han population. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.09.012DOI Listing

Effect of Fat Graftıng on Postoperatıve Intraabdomınal Adhesions on a Rat Model.

Arch Med Res 2018 May 28;49(4):235-239. Epub 2018 Sep 28.

Department of Plastic, Reconstructive and Aesthetic Surgery, Medicana International Samsun Hospital, Samsun, Turkey.

Background: We aimed to evaluate the effect of fat grafting on postoperative intraabdominal adhesions by promoting mesothelial healing on a rat model.

Methods: Thirty Wistar albino rats were grouped as control and fat grafted group. They all underwent laparotomy, anterior cecal wall abrasion and peritoneal injury. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.09.009DOI Listing
May 2018
4 Reads