3,075 results match your criteria Archives of medical research[Journal]


Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain.

Arch Med Res 2020 May 22. Epub 2020 May 22.

BioScience Research Centre and Department of Medicine, Gayatri Vidya Parishad Medical College and Hospital, Visakhapatnam, India; UND Life Sciences, Battle Ground, Washington, USA. Electronic address:

Objective: To study whether resolvin D1 (RvD1), a metabolite of docosahexaenoic acid (DHA), prevents NA-STZ-induced type 2 diabetes mellitus (type 2 DM) in vivo and if so, what could be the mechanism of this action.

Material And Methods: Single intra-peritoneal (i.p) injection of NA-STZ (175 mg/kg body weight of NA and 65 mg/kg of STZ) was injected simultaneously with RvD1 (60 ng/animal) (injected for 5 consecutive days) to Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.05.002DOI Listing

A Reusable Mask for Coronavirus Disease 2019 (COVID-19).

Arch Med Res 2020 Apr 10. Epub 2020 Apr 10.

Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan. Electronic address:

The outbreak of Novel Coronavirus is causing an intensely feared globally. World Health Organization has even declared that it is a global health emergency. The simplest method to limit the spread of this new virus and for people to protect themselves as well as the others is to wear a mask in crowded places. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151523PMC

Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV.

Arch Med Res 2020 May 6. Epub 2020 May 6.

Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

At the end of the year 2019, the novel coronavirus (2019-nCoV) was spreading in Wuhan, China, and the outbreak process has a high speed. It was recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Coronaviruses are enveloped and single-stranded RNA that have several families including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200354PMC

Ongoing Challenges Faced in the Global Control of COVID-19 Pandemic.

Arch Med Res 2020 Apr 29. Epub 2020 Apr 29.

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

The recent pandemic caused by SARS-CoV-2 has now spread worldwide and caused more than 51,000 deaths, by April 2nd 2020. As predicted, there are several obstacles for medical and governmental authorities to efficiently manage this respiratory illness. In spite of appropriated supplies, most hospitals are suffering from a scarcity of free beds, protective masks, sanitizing liquids and even ECMO machines for patients with severe cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188630PMC

Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More.

Arch Med Res 2020 May 12. Epub 2020 May 12.

Department of Biotechnology, School of Life Science & Biotechnology, Adamas University, Kolkata, India.

COVID-19 is now pandemic throughout the world. Scientist, doctors are searching for effective therapy of this diseases. The remdesivir, an antiviral drug, is appeared as 'molecule of hope' for the treatment of this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214327PMC

COVID-19 and Dysfunctional Endothelium: The Mexican Scenario.

Arch Med Res 2020 May 15. Epub 2020 May 15.

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogenesis, Hospital General Regional No.1, Dr. Carlos MacGregor Sánchez Navarro, Instituto Mexicano del Seguro Social, Ciudad de México, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225698PMC

Survival Comparision of Three-dimensional Radiotherapy Alone with Chemoradiotherapy for Esophageal Squamous Cell Carcinoma.

Arch Med Res 2020 May 14. Epub 2020 May 14.

Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China.

Background And Objective: To compare the survival of esophageal squamous cell carcinoma (ESCC) patients who received chemoradiotherapy (CRT) or radiotherapy (RT) alone.

Methods: A total of 753 well-matched patients were enrolled. A total of 299 patients were treated with CRT, and 454 patients were treated with RT alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.013DOI Listing

A Review of Current Interventions for COVID-19 Prevention.

Arch Med Res 2020 Apr 30. Epub 2020 Apr 30.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan, Deemed to be University, Bhubaneswar, Odisha, India. Electronic address:

The recent outbreak of CoVID-19 is declared as a global public health emergency of international concern by the World Health Organization (WHO). A fresh figure of 2268011 positive cases and 155185 death records (till April 18 2020) across the worldwide signify the severity of this viral infection. CoVID-19 infection is a pandemic, surface to surface communicable disease with a case fatality rate of 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190516PMC

P38 MAPK and Nrf2 Activation Mediated Naked Gold Nanoparticle Induced Heme Oxygenase-1 Expression in Rat Aortic Vascular Smooth Muscle Cells.

Arch Med Res 2020 May 11. Epub 2020 May 11.

School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Background And Aims: Heme oxygenase 1 (HO-1) is mainly regulated by the redox-sensitive transcription factor, namely nuclear factor erythroid 2-related factor 2 (Nrf2). We previously found a physically-made gold nanoparticle (GNP) can affect migration, adhesion, and proliferation of rat aortic vascular smooth muscle cells (VSMCs). This study was sought to investigate whether the GNP can affect HO-1 expression level in VSMCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.015DOI Listing

COVID-19: Developing from an Outbreak to A Pandemic.

Arch Med Res 2020 May 13. Epub 2020 May 13.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219390PMC

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection.

Arch Med Res 2020 Apr 30. Epub 2020 Apr 30.

Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, La Escalera, Gustavo A. Madero 07320, Ciudad de México, México.

The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation, cell death, and other pathophysiological processes, which could be link with a redox imbalance or oxidative stress. These phenomena are substantially increased during aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190501PMC

D-Dimer as a Biomarker of Severity and Adverse Outcomes in Patients With Community Acquired Pneumonia.

Arch Med Res 2020 Apr 24. Epub 2020 Apr 24.

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Hospial General Regional, No 1. Dr. Carlos Mac Gregor Sánchez Navarro, Instituto Mexicano de Seguridad Social, Ciudad de México, Mexico. Electronic address:

Background: Community-acquired pneumonia (CAP) stands as a main cause of hospitalization and mortality worldwide. Because of their limitation scoring systems such as CURB-65 and Pneumonia Severity Index (PSI) may underestimate the severity of the disease. Intravascular and intra-alveolar activation of coagulation factors may lead to fibrin deposition in alveoli and lung interstitium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.014DOI Listing

COVID-19 and Moral Imperialism in Multinational Clinical Research.

Arch Med Res 2020 Apr 29. Epub 2020 Apr 29.

UNESCO Chair and Post Graduate Program in Bioethics, University of Brasilia, Brasilia, DF, Brazil.

A TV debate in April 2020 between two French doctors regarding the benefits of testing a coronavirus vaccine in Africa where there are no masks or treatments available has led to international criticism. This case highlights a problematic ethical double standard in multinational clinical research: trials that would be considered unethical in high income countries (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188637PMC

Sofosbuvir as Repurposed Antiviral Drug Against COVID-19: Why Were We Convinced to Evaluate the Drug in a Registered/Approved Clinical Trial?

Arch Med Res 2020 Apr 29. Epub 2020 Apr 29.

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

COVID-19 is a devastating global pandemic around the world. While the majority of infected cases appear mild, in some cases individuals present respiratory complications with possible serious lung damage. There are no specific treatments for COVID-19 as yet, though a number are under evaluation, including experimental antivirals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188631PMC

Tackling the COVID-19 Pandemic.

Arch Med Res 2020 Apr 24. Epub 2020 Apr 24.

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

After the initial outbreak of the SARS-CoV-2 epidemic (now called COVID-19)-in Wuhan, China-and its subsequent fast dispersion throughout the world, many questions regarding its pathogenesis, genetic evolution, prevention, and transmission routes remain unanswered but fast explored. More than 100,000 confirmed, infected cases within a relatively short period of time globally corroborated the presumption that a pandemic will develop; such a pandemic will require a suite of global intervention measures. Consequently, different countries have reacted differently to the COVID-19 outbreak, but a uniform global response is necessary for tackling the pandemic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180380PMC

Histological and Mechanical Behavior of INC 01 and 02 Bare Metal Stents against a Commercial Stent: A Preclinical Study in a Porcine Model.

Arch Med Res 2020 May 3. Epub 2020 May 3.

Subdirección de Innovación y Desarrollo Tecnológico, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address:

Background: PCI is an expensive procedure in our population and it implies a huge cost for the institutions and National Health Service.

Aim Of The Study: The main objective was to evaluate the technical and biological success of two stents designed in Mexico.

Methods: Ten York pigs, 4-6 months of age, underwent implantation of the bare metal INC-01 (10 stents) and INC-02 (6 stents) coronary stent in addition to a conventional commercial stent (10 stents). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.016DOI Listing

Influenza A H1N1 Virus 2009 Synthetic Hemagglutinin and Neuraminidase Peptides for Antibody Detection.

Arch Med Res 2020 Apr 30. Epub 2020 Apr 30.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico. Electronic address:

Background: Influenza serologic diagnosis is mainly based on hemagglutination inhibition and microneutralization methods, both methods require handling living viruses under an enhanced biosafety level.

Aim: The current study was performed for developing an ELISA using synthetic peptides to detect influenza A H1N1 virus 2009 specific antibodies in serum and saliva.

Methods: Alignments were made with H1N1 hemagglutinin and neuraminidase (HA and NA, respectively) sequences; only conserved sites were used for antigenicity prediction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.011DOI Listing

Reply to: Bioactive Lipids and Coronavirus (COVID-19)-further Discussion.

Authors:
Undurti N Das

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

UND Life Sciences, Battle Ground, WA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158824PMC

Inappropriate Antibiotic Consumption as a Possible Cause of Inflammatory Storm and Septic Shock in Patients Diagnosed with Coronavirus Disease 2019 (COVID-19).

Arch Med Res 2020 Apr 4. Epub 2020 Apr 4.

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

The novel coronavirus (SARS-CoV-2) infection which has been known as Coronavirus diseases 2019 (COVID-19) has become an endemic emergent situation by the World Health Organization. So far, no successful specific treatment has been found for this disease. As has been reported, most of non-survivor patients with COVID-19 (70%) had septic shock which was significantly higher than survived ones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129207PMC

Barriers and Facilitators in Timely Detection of Chronic Kidney Disease: Evidences for Decision-Makers.

Arch Med Res 2020 Apr 23. Epub 2020 Apr 23.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico.

Chronic Kidney Disease (CKD) is classified, according to the glomerular filtratation rate. Timely diagnosis during the first three stages represents a lower expenditure for health systems in the treatment of this disease. Thus, this study intends to identify barriers and facilitators in timely detection of CKD, from the perspective of healthcare providers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.009DOI Listing

Immunomodulatory and Tissue-preserving Effects of Human Dental Follicle Stem Cells in a Rat Cecal Ligation and Perforation Sepsis Model.

Arch Med Res 2020 Apr 16. Epub 2020 Apr 16.

Department of Anesthesiology and Reanimation, School of Medicine, Marmara University, Istanbul, Turkey. Electronic address:

Background: Mesenchymal stem cells may be used for the treatment of sepsis. Dental follicle stem cells (DFSCs) are easily accessible but have not been studied in vivo or in clinical trials in sepsis models.

Aim Of The Study: We aim to elucidate DFSC effects on host immunological functions in a rat cecal ligation and perforation (CLP) sepsis model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.010DOI Listing

Global Threat of SARS-CoV-2/COVID-19 and the Need for More and Better Diagnostic Tools.

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Colombia; Grupo de Investigación Biomedicina, Facultad de Medicine, Fundación Universitaria Autónoma de las Americas, Pereira, Risaralda, Colombia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158838PMC
April 2020
2.406 Impact Factor

Case-finding: Fast, Available, and Efficient Font-line Diagnostics for SARS-CoV-2.

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

Faculty of Medical Sciences, Department of Bacteriology, Tarbiat Modares University, Tehran, Iran. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158788PMC

Comparative Global Epidemiological Investigation of SARS-CoV-2 and SARS-CoV Diseases Using Meta-MUMS Tool Through Incidence, Mortality, and Recovery Rates.

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

COVID-19 is a novel coronavirus that was reported by the world health organization in late December 2019. As an unexplained respiratory disease epidemic, which is similar to respiratory syndrome coronavirus SARS-CoV, it rapidly spread all over the world. The study aims to compare several parameters of COVID-19 and SARS-CoV infectious diseases in terms of incidence, mortality, and recovery rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158781PMC
April 2020
2.406 Impact Factor

Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19.

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

The current outbreak of COVID-19 (coronavirus) has been identified by World Health Organization (WHO) as a global pandemic. With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. Bioactive lipids with an array of known health-promoting properties can be suggested as effective agents in alleviating acute respiratory stress induced by virus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158763PMC
April 2020
2.406 Impact Factor

Optimal Medical Treatment or Invasive Approach in Patients with Significantly Obstructive Coronary Artery Disease and Ischemia.

Arch Med Res 2020 Apr 20. Epub 2020 Apr 20.

Nuclear Cardiology Department, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City, Mexico; Physiology Department, School of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico. Electronic address:

Introduction: Stable ischemic heart disease (SIHD) is a condition that develops in subjects after myocardial infarction. Evidence suggests that optimal medical treatment (OMT) is not inferior to intervention (INT) using percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).

Aim: To compare clinical outcomes in subjects with SIHD who only received OMT and those who received INT+OMT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.002DOI Listing

Bioactive Lipids and Coronavirus (COVID-19).

Arch Med Res 2020 Apr 15. Epub 2020 Apr 15.

Department of Community Medicine, Dr DY Patil University, Pune, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158796PMC

Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats.

Arch Med Res 2020 Apr 10. Epub 2020 Apr 10.

Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México. Electronic address:

Background: Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.013DOI Listing
April 2020
2.406 Impact Factor

Response to: Knee Osteoarthritis and Hip Osteoarthritis: Is there a Shared Susceptibility?

Arch Med Res 2020 Apr 9. Epub 2020 Apr 9.

Department of Orthopedics, the First Hospital of Tianshui City, Tianshui, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.010DOI Listing

Response to: Night Shift Work and Breast Cancer in Mexican Women.

Arch Med Res 2020 Apr 9;51(3):279. Epub 2020 Apr 9.

Decanato de Ciencias de la Salud, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.002DOI Listing

An Overview of Nicotinic Cholinergic System Signaling in Neurogenesis.

Arch Med Res 2020 Apr 9. Epub 2020 Apr 9.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Persian Medicine, Faculty of Persian Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; East-Azerbaijan Comprehensive Stroke Program, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

The production of new neurons continues in the adult mammalian brain because of the sustained proliferation and differentiation of neural stem cells (NSCs) in neurogenic regions. The subventricular zone (SVZ), lining the lateral ventricle, and the subgranular zone (SGZ), which is in the dentate gyrus (DG) of the hippocampus, are the central regions of neurogenesis in the brain. Neurogenesis brings great hope for repairing a damaged brain and motivates researchers to detect the controlling signals of this process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.014DOI Listing
April 2020
2.406 Impact Factor

Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?

Arch Med Res 2020 Apr 4. Epub 2020 Apr 4.

Departamento de Medicina Interna, Hospital General, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico. Electronic address:

In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that has been recognized as target to which the virus bind to cells. Although this hypothesis is possible, it may also have other explanations which are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128661PMC

Variants in FGF18 Gene and Knee Osteoarthritis.

Arch Med Res 2020 Apr 9. Epub 2020 Apr 9.

Honorary Professor, dr DY Patil University, Pune, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.009DOI Listing

Clinical Spectrum and Long-term Outcome of 183 Cases of Ebstein's Anomaly, Experience of Mexican Population.

Arch Med Res 2020 Apr 3. Epub 2020 Apr 3.

Consulta externa, Instituto Nacional de Cardiología, Ignacio Chavez, Ciudad de México, México.

Background: Ebstein's anomaly (EA) is a myopathy of the right ventricle that causes a variable spectrum of tricuspid valve delamination failure with diverse clinical and anatomical presentation. We reviewed our data of EA to establish an association between clinical and echocardiographic findings with mortality.

Methods: We divided patients in infants, Children/adolescents (Ch/A), and adults, according to age of presentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.008DOI Listing

Transthyretin Regulated by linc00657/miR-205-5p Promoted Cholesterol Metabolism by Inducing SREBP2-HMGCR and Inhibiting LXRα-CYP7A1.

Arch Med Res 2020 Mar 30. Epub 2020 Mar 30.

Department of Vascular Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:

Background: Transthyretin functions as a serum transport protein for retinol. Transthyretin has been found associated with amyloid diseases and it is an important nutrition indicator. For this study, we aimed to investigate the up and down stream molecular mechanisms of Transthyretin in cholesterol metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.009DOI Listing

Practical Strategies Against the Novel Coronavirus and COVID-19-the Imminent Global Threat.

Arch Med Res 2020 04 27;51(3):280-281. Epub 2020 Mar 27.

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

The last month of 2019 harbingered the emergence of a viral outbreak that is now a major public threat globally. COVID-19 was first diagnosed and confirmed in a couple of cases with unknown pneumonia; the patients lived in, or travelled to, Wuhan, the capital of China's Hubei province. People now face a complex challenge that deserves urgent intervention by all involved in medical healthcare globally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.005DOI Listing

Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin.

Arch Med Res 2020 Mar 27. Epub 2020 Mar 27.

Unidad de Investigación Médica-Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas, México. Electronic address:

Background: Diabetic foot ulcers (DFUs) are one of the main complications in patients with type 2 diabetes mellitus (DM2), previous studies have reported that DM2 patients have lower production of host defense peptides (HDP).

Aim Of The Study: To investigate the expression of RNase 7, cathelicidin, HBD-2, and psoriasin in biopsies obtained from DM2 patients with or without DFU.

Methods: Biopsies from DFU patients grade 3 according to Wagner's classification, from diabetic patients without ulcer and from healthy donors were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.006DOI Listing

Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?

Authors:
Undurti N Das

Arch Med Res 2020 04 27;51(3):282-286. Epub 2020 Mar 27.

UND Life Sciences, Battle Ground, WA. Electronic address:

SARS-CoV-2, SARS and MERS are all enveloped viruses that can cause acute respiratory syndrome. Arachidonic acid (AA) and other unsaturated fatty acids (especially eicosapentaenoic acd, EPA and docosahexaenoic acid DHA) are known to inactivate enveloped viruses and inhibit proliferation of various microbial organisms. The pro-inflammatory metabolites of AA and EPA such as prostaglandins, leukotrienes and thromboxanes induce inflammation whereas lipoxins, resolvins, protectins and maresins derived from AA, EPA and DHA not only suppress inflammation but also enhance would healing and augment phagocytosis of macrophages and other immunocytes and decrease microbial load. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.004DOI Listing

ER Stress Amelioration by Saxagliptin Protects the Liver Against Fructose-induced Insulin Resistance.

Arch Med Res 2020 Mar 26. Epub 2020 Mar 26.

Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Demiroglu Bilim University, Istanbul, Turkey. Electronic address:

Background/aim: The study is aimed to demonstrate whether saxagliptin treatment may reduce endoplasmic reticulum (ER) stress, oxidative damage, and inflammation in the liver of fructose-induced insulin resistance (IR) rats.

Material And Methods: Twenty-eight rats were divided as control, IR, saxagliptin treatment (ST) and IR+ST groups. IR caused by fructose (10%) administration for 10 weeks and, ST was administered for 15 d. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.007DOI Listing

Brugada Syndrome Caused by Sodium Channel Dysfunction Associated with a SCN1B Variant A197V.

Arch Med Res 2020 Apr 16;51(3):245-253. Epub 2020 Mar 16.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. Electronic address:

Objective: We aimed to identify and characterize a SCN1B variant, A197V, associated with Brugada Syndrome (BrS).

Methods: Whole-exome sequencing was employed to explore the potential causative genes in 8 unrelated clinically diagnosed BrS patients. A197V variant was only detected in exon 4 of SCN1B in a 46 year old patient, who was admitted due to syncope. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.003DOI Listing

Night Shift Work and Breast Cancer in Mexican Women.

Arch Med Res 2020 Apr 10;51(3):278. Epub 2020 Mar 10.

Dirección de Administración y Desarrollo de Personal, Instituto de Seguridad Social del Estado de México y Municipios, Unidad de Enseñanza e Investigación, Toluca de Lerdo, Mexico. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.003DOI Listing

Potential Anticancer Effect of Celastrol on Hepatocellular Carcinoma by Suppressing CXCR4-related Signal and Impeding Tumor Growth in Vivo.

Arch Med Res 2020 Mar 10. Epub 2020 Mar 10.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background: Potential agents that can effectively treat hepatocellular carcinoma (HCC) are being continuously explored.

Methods: Celastrol extracted from roots of an ancient Chinese herb, Tripterygium wilfordii (Thunder god vine), has been identified as a potential anti-tumor agent. In this study, the molecular mechanisms underlying the action of celastrol on cell proliferation and chemokine CXCR4-related signal pathway associated with tumor growth were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.03.001DOI Listing

Serum C1q/TNF-Related Protein-2 (CTRP2) Levels are Associated with Coronary Artery Disease.

Arch Med Res 2020 Feb 6;51(2):167-172. Epub 2020 Mar 6.

Department of Laboratory Sciences, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran. Electronic address:

Recent studies have shown that complement C1q tumor necrosis factor related proteins (CTRPs) such as adiponectin, have different regulatory roles on the cardiovascular system. CTRP2 is the most similar to adiponectin and one of the best characterized beneficial adipokines important in the regulation of whole body metabolism. However, there were no studies about the relationship between CTRP2 and Coronary artery disease (CAD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.01.009DOI Listing
February 2020
2.406 Impact Factor

Helveticoside Exhibited p53-dependent Anticancer Activity Against Colorectal Cancer.

Arch Med Res 2020 Apr 6;51(3):224-232. Epub 2020 Mar 6.

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Background: Investigation into the anti-cancer activities of natural products and their derivatives represents an efficient approach to develop safe and effective chemotherapeutic agents for the treatment of colorectal cancer. Helveticoside is a biologically active component of the seed extract of Descurainia sophia. This compound has been reported to regulate the genes related to cell proliferation and apoptosis in lung cancer cells, however its anticancer activity has not been fully explored yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.007DOI Listing

Oral Ciprofloxacin Pharmacokinetics in Healthy Mexican Volunteers and Other Populations: Is There Interethnic Variability?

Arch Med Res 2020 Apr 3;51(3):268-277. Epub 2020 Mar 3.

Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México. Electronic address:

Background: There is evidence that the pharmacokinetics of certain drugs in Mexicans may differ with respect to other ethnic groups. On the other hand, there is controversy about the existence of interethnic variability in the pharmacokinetics of ciprofloxacin.

Aim Of The Study: To study oral ciprofloxacin pharmacokinetics in Mexicans at various dose levels and make comparisons with other populations in order to gain insight on interethnic variability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.008DOI Listing

CpG Oligodeoxynucleotides Induces Apoptosis of Human Bladder Cancer Cells via Caspase-3-Bax/Bcl-2-p53 Axis.

Arch Med Res 2020 Apr 3;51(3):233-244. Epub 2020 Mar 3.

School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address:

Objective: To evaluate the anti-cancer effect of unmethylated cytosine-phosphorothioate-guanine (CpG)-containing oligodeoxynucleotides (ODNs) on human bladder cancer UM-UC-3 cells, our study was carried out.

Methods: The viability of cells (UM-UC-3, T24 and SV-HUC-1) with CpG ODN treatments was examined by cell counting kit-8 (CCK-8) assay. Apoptosis and cell cycle phase were determined by flow cytometry analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.005DOI Listing

Qualitative Study of the Processes of Transgender-Men Identity Development.

Arch Med Res 2020 01 26;51(1):95-101. Epub 2020 Feb 26.

Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico. Electronic address:

Objective: Describe and analyze the mental health service and medical needs of a group of transgender men from the point when they changed their gender identity to male.

Material And Method: Transgender men volunteers who attended a specialized care center in Mexico City answered a qualitative semi-structured interview to explore their needs as well as the adversities they unnecessarily face due to the lack of information and care for their condition. Interviews were audio-recorded and transcribed for thematic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.01.003DOI Listing
January 2020

Autologous CXCR4+ Hematopoietic Stem Cells Injected into the Scar Tissue of Chronic Myocardial Infarction Patients Normalizes Tissue Contractility and Perfusion.

Arch Med Res 2020 Feb 26;51(2):135-144. Epub 2020 Feb 26.

Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Background: Chronic myocardial infarction (CMI), represents a public health and a financial burden. Since stem cell transplant is used to regenerate cardiac tissue after acute myocardial infarction.

Aim Of The Study: To determine if autologous CXCR4 stem cells could restore damaged myocardial tissue in patients with CMI lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2019.12.014DOI Listing
February 2020

γδ T Cells Number, CD200, and Flt3 Expression Is Associated with Higher Progression Free Survival in Patients with Chronic Myeloid Leukemia.

Arch Med Res 2020 Apr 26;51(3):194-203. Epub 2020 Feb 26.

Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México. Electronic address:

Background: Tumor immunoedition involves alterations in cells of immune system, which may play an important role in the immunosurveillance of patients with cancer diseases.

Aim Of The Study: To determine the association between the number of immune cells and the expression of surface markers in leukemic cells of patients with de novo CML who achieved molecular response.

Methods: A longitudinal study was conducted in 31 patients with de novo CML. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.01.013DOI Listing

LDLR Gene Mutation p.Asp360His and Familial Hypercholesterolemia in a Mexican Community.

Arch Med Res 2020 Feb 26;51(2):153-159. Epub 2020 Feb 26.

División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. Electronic address:

Background: Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by an increased LDL-cholesterol (LDLc) serum concentration and premature cardiovascular disease. Screening of small populations where at least one homozygous (HoFH) patient has been identified may be a proper approach for detecting FH patients. Previously, we reported an HoFH patient carrying the mutation p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2019.12.017DOI Listing
February 2020