533 results match your criteria Archives of endocrinology and metabolism[Journal]


Challenges in monitoring GnRH analog treatment in central precocious puberty.

Arch Endocrinol Metab 2020 Apr 8;64(2):103-104. Epub 2020 May 8.

Unidade de Desenvolvimento e Laboratório de Hormônios e Genética Molecular LIM-42, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000241DOI Listing

The diagnosis of primary hyperparathyroidism in developing countries remains in the past century: still with bones, stone and groans.

Arch Endocrinol Metab 2020 Apr 8;64(2):101-102. Epub 2020 May 8.

Divisão de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000240DOI Listing

Factors associated with overweight and abdominal obesity in Brazilian school-aged children: a comprehensive approach.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Laboratório de Farmacologia Molecular, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brasil.

Objective: We investigated the association between demographic, socio-economic, perinatal, parental and lifestyle-related factors with general and abdominal obesity among prepubertal children aged 6 to 8 years in a Southeastern city of Brazil.

Subjects And Methods: A total of 486 children were randomly selected from public schools in the city of Patos de Minas, and examined to determine body mass index (BMI) and waist circumference (WC). Demographic, socio-economic, perinatal, parental and lifestyle-related data were obtained and assessed as independent risk factors for overweight/obesity and abdominal obesity, using multiple regression analysis. Read More

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http://dx.doi.org/10.20945/2359-3997000000239DOI Listing

Evaluation of factors affecting sexual dysfunction in female patients with diabetes mellitus.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Clinic of Urology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Objective: Our objective in this study was to evaluate the factors predicting female sexual dysfunction (FSD) in patients with diabetes mellitus (DM).

Subjects And Methods: The study included 149 women with DM. Sexual function was evaluated with the Female Sexual Function Index (FSFI) questionnaire, in which total scores under 26. Read More

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http://dx.doi.org/10.20945/2359-3997000000238DOI Listing

Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brasil.

Objective: Prematurity and low birth weight predispose preterm infants to cardiovascular disease in later life. Is the metabolic profile of these children impacted by the relation between birth weight and gestational age (GA)? This study aimed to evaluate whether the relationship between birth weight and GA of preterm infants has a positive correlation with the metabolic profile from birth to the sixth month of corrected age.

Subjects And Methods: This is a longitudinal, prospective study with a cohort of 70 preterm and 54 term infants, who were enrolled in the study and shared into two groups: Appropriate for GA (AGA) and Small for GA (SGA), both classified at birth by Fenton and Kim curves. Read More

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http://dx.doi.org/10.20945/2359-3997000000237DOI Listing

ARMC5 mutations are associated with high levels of proliferating cell nuclear antigen and the presence of the serotonin receptor 5HT4R in PMAH nodules.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Instituto de Ciências Biomédicas, Departamento de Anatomia, Universidade de São Paulo, São Paulo, SP, Brasil.

Objective: To analyze the morphological and functional characteristics of primary macronodular adrenal hyperplasia (PMAH) nodules carrying or not carrying ARMC5 mutations and the consequences of the presence of mutations in terms of the pattern of macronodule composition and functional state.

Subjects And Methods: The analyses were performed by hematoxylin-eosin staining, immunohistochemistry, microdissection of spongiocyte tissue and RT-qPCR of histological sections from 16 patients diagnosed with PMAH with germline (5) or germline/somatic mutations (5) and without mutations (6) in the ARMC5 gene.

Results: Hyperplastic nodules were predominantly composed of spongiocytes in mutated and nonmutated sections. Read More

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http://dx.doi.org/10.20945/2359-3997000000236DOI Listing

Central and peripheral blood pressures and arterial stiffness increase in hypoparathyroidism.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

University of Health Sciences Turkey, Keçiören Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.

Objective: The aim of the present study was to evaluate whether arterial stiffness is affected in the patients with hypoparathyroidism through pulse wave analysis (PWA).

Subjects And Methods: Sixty-three patients diagnosed with hypoparathyroidism and sixty volunteers were evaluated for the study. When 21 patients were excluded in the hypoparathyroidism group due to exclusion criteria, the research continued with 42 patients and 60 volunteers who are similar to the patients in terms of age, gender and body mass index (BMI). Read More

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http://dx.doi.org/10.20945/2359-3997000000234DOI Listing

Determining the relationship between dietary iodine intake, urinary iodine excretion and thyroid functions in people with type 2 diabetes mellitus.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Ankara Yildirim Beyazit University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.

Objective: Type 2 diabetes mellitus (T2DM) is a worldwide health problem, and medical nutrition therapy is essential for improving the quality of life of patients with type 2 diabetes. Salt restriction may lead to iodine deficiency in these patients. Moreover, type 2 diabetes can be an indirect reason for thyroid disorders. Read More

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http://dx.doi.org/10.20945/2359-3997000000233DOI Listing

Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

División Endocrinología, Hospital General de Agudos Dr. Carlos G. Durand, Buenos Aires, Argentina.

The usual clinical presentation of non-functioning pituitary adenoma (NFPA) consists of symptoms of mass effect and hypopituitarism. NFPA is a rare condition in young women and an uncommon complication during pregnancy. We present the outcome of three patients with NFPA during pregnancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000232DOI Listing

Neonatal presentation of growth hormone deficiency in CHARGE syndrome: the benefit of early treatment on long-term growth.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Unidade de Endocrinologia e Diabetologia Pediátrica, Departamento de Pediatria, Centro Hospitalar Universitário de São João, Porto, Portugal.

CHARGE syndrome is a complex disorder involving multiple congenital anomalies and is caused by heterozygous mutations in the CHD7 gene. Growth retardation is a characteristic finding and about 10% of cases present growth hormone (GH) deficiency. GH treatment of short stature in CHARGE syndrome has shown some benefit, but normal height is rarely attained. Read More

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http://dx.doi.org/10.20945/2359-3997000000231DOI Listing

Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo (USP), São Paulo, SP, Brasil.

Objective: Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone - PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Read More

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http://dx.doi.org/10.20945/2359-3997000000230DOI Listing

Comparison of glucose measurement on dried blood spots versus plasma samples in pregnant women with and without anemia.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Medicina Interna, Unidade de Diabetes e Nutrologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: Compare the concordance degree between plasma glucose and glucose measurements on Dried Blood Spots (DBS) during pregnancy.

Subjects And Methods: Glucose measurement was performed in pregnant women after a fast of 8-12 hours. Venous blood was collected with sodium fluoride, the plasma was separated, and glucose measured by the enzymatic oxidase glucose method. Read More

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http://dx.doi.org/10.20945/2359-3997000000229DOI Listing

Relationship between sleep disturbances, lipid profile and insulin sensitivity in type 1 diabetic patients: a cross-sectional study.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Medicina Clínica, Universidade Federal Fluminense (UFF), Niterói, RJ, Brasil.

Objective: The consequences of sleep deprivation in type 1 diabetes (T1D) patients are poorly understood. Our aim was to determine how sleep disorders influence lipid profile and insulin sensitivity in T1D patients.

Materials And Methods: This was a cross-sectional study at a public university hospital. Read More

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http://dx.doi.org/10.20945/2359-3997000000228DOI Listing

Decreased serum levels of IL-27and IL-35 in patients with Graves disease.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Department of Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

Objectives: Graves' disease (GD) is an autoimmune disease causing the overproduction of the thyroid hormone from thyroid gland. This disease is mainly the result of the production of antibodies against TSH receptors. Cytokines play an important role in orchestrating the pathophysiology in autoimmune thyroid disease. Read More

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http://dx.doi.org/10.20945/2359-3997000000227DOI Listing

Agreement between equations-estimated resting metabolic rate and indirect calorimetry-estimated resting metabolic rate in low-income obese women.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brasil.

Objectives: Indirect calorimetry is established as a gold standard to determine the resting metabolic rate (RMR), however, its clinical use is limited, especially in low-income settings. Thus, the use of predictive equations appear as an alternative to estimate the RMR, but its precision is debatable, especially in obese individuals and in populations without specifically developed equations. To evaluate the agreement between the RMR estimated by equations and by indirect calorimetry in low-income obese women. Read More

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http://dx.doi.org/10.20945/2359-3997000000226DOI Listing

Effects of yacon flour associated with an energy restricted diet on intestinal permeability, fecal short chain fatty acids, oxidative stress and inflammation markers levels in adults with obesity or overweight: a randomized, double blind, placebo controlled clinical trial.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Universidade Federal de Viçosa, Departamento de Nutrição e Saúde, Viçosa, MG, Brasil.

Objectives: Yacon flour is rich in bioactive compounds (phenolic compounds and fructooligosaccharides (FOS)), and may therefore reduce the risk of diseases associated with excess body weight. However, its effect on fecal short chain fatty acids (SCFA), intestinal permeability, oxidative stress and inflammation markers has not been studied in adult humans with excess body weight. Thus, we evaluated the effect of the consumption of yacon flour on these variables. Read More

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http://dx.doi.org/10.20945/2359-3997000000225DOI Listing

Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Programa de Pós-graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointed out as an important therapy for increasing and recovering sensitivity to FGF21. Read More

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http://dx.doi.org/10.20945/2359-3997000000224DOI Listing

Health-related quality of life associated with diabetic retinopathy in patients at a public primary care service in southern Brazil.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Programa de Pós-Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Objective: This study aimed to establish the utility values of different health states associated with diabetic retinopathy in a Brazilian sample to provide input to model-based economic evaluations.

Subjects And Methods: This cross-sectional study was performed in a sample of patients with type 2 diabetes mellitus (T2D) who underwent teleophthalmology screening at a primary care service from 2014 to 2016. Five diabetic retinopathy health states were defined: absent, non-sight-threatening, sight-threatening, and bilateral blindness. Read More

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http://dx.doi.org/10.20945/2359-3997000000223DOI Listing

A two-year follow-up of asfotase alfa replacement in a patient with hypophosphatasia: clinical, biochemical, and radiological evaluation.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Medicina, Disciplina de Endocrinologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.

Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benefit in the treatment of HPP. Read More

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http://dx.doi.org/10.20945/2359-3997000000222DOI Listing

Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Unit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University Hospital of Siena, Siena, Italy.

Checkpoint inhibitors have substantially improved the prognosis for patients with advanced malignancy. Treatment with immunomodulants has the ability to reactivate the immune system against tumor cells, but can also trigger the development of immune-related adverse events that reflects a loss of tolerance of the immune system for self-antigens. Regarding the endocrine system, thyroid and pituitary are the most frequent glands involved; in particular hypophysitis is commonly observed with anti-CTLA4 with a variable impaired anterior pituitary dysfunction (mainly ACTH and TSH dysregulation) while a posterior pituitary dysfunction has been rarely described. Read More

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http://dx.doi.org/10.20945/2359-3997000000221DOI Listing

Short-term renal and metabolic effects of low dose vildagliptin treatment added-on insulin therapy in non-proteinuric patients with type 2 diabetes: open-label randomized prospective study.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Institute of Endocrinology , Almazov National Medical Research Centre , Saint Petersburg , Russia.

Objective: The aim of this randomized comparative study was to assess renal and metabolic effects of vildagliptin in insulin-treated type 2 diabetes (T2DM) patients without overt chronic kidney disease.

Subjects And Methods: We randomized 47 insulin-treated non-proteinuric patients with satisfactory controlled T2DM and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m 2 either to continue insulin therapy (control) or to receive combined insulin-vildagliptin treatment (VIG group). Read More

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http://dx.doi.org/10.20945/2359-3997000000220DOI Listing

A comparison of the quantitative evaluation of in situ parathyroid gland perfusion by indocyanine green fluorescence angiography and by visual examination in thyroid surgery.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Istanbul Bagcilar Training and Research Hospital , Department of General Surgery , Istanbul , Turkey.

Objective: The most vital complications of thyroidectomy are recurrent nerve damage and hypocalcaemia. We aimed to compare the tissue perfusion scores (PS) of IG fluorescence angiography (IGFA) and visual examination by the surgeon after total thyroidectomy.

Subjects And Methods: Forty-three patients were accepted into the study. Read More

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http://dx.doi.org/10.20945/2359-3997000000219DOI Listing

Visceral fat index: a novel predictor for coronary collateral circulation.

Arch Endocrinol Metab 2020 Apr 27;64(2):150-158. Epub 2020 Mar 27.

Departments of Cardiology, Training and Research Hospital, University of Health Sciences Antalya, Antalya, Turkey.

Objective This study was designed to investigate the role of visceral adiposity along with other clinical parameters in predicting poor coronary collateral circulation (CCC) among patients with severe obstructive coronary artery disease (CAD). Subjects and methods A total of 135 patients with severe obstructive CAD and good (n = 70) or poor (n = 65) CCC were included. Data on angiographically detected CCC, the quality criteria for CCC (Rentrop scores) and visceral fat index (VFI) obtained via bioelectrical impedance were compared between good and poor CCC groups. Read More

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http://dx.doi.org/10.20945/2359-3997000000218DOI Listing

Determining an optimal cut-off value for follicle-stimulating hormone to predict microsurgical testicular sperm extraction outcome in patients with non-obstructive azoospermia.

Arch Endocrinol Metab 2020 Apr 27;64(2):165-170. Epub 2020 Mar 27.

Department of Radiology, Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective To determine the optimal cut-off value for follicle stimulating hormone (FSH) to predict the outcome of microsurgical testicular sperm extraction (micro-TESE) in patients with nonobstructive azoospermia (NOA). Subjects and methods We included a total number of 180 patients with NOA. The serum level of FSH was determined and all the subjects underwent micro-TESE. Read More

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http://dx.doi.org/10.20945/2359-3997000000217DOI Listing

Diabetes-Specific Questionnaires Validated in Brazilian Portuguese: A Systematic Review.

Arch Endocrinol Metab 2020 Apr 27;64(2):111-120. Epub 2020 Mar 27.

Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.

Two researchers conducted independent searches on five different electronic databases: PubMed/MEDLINE, Embase, SciELO, LiLACS and Web of Science. Studies were selected that covered cross-cultural adaptation methodology and validation in Brazil with type 1 and type 2 diabetes patients of any age. After reading the full-text articles, data related to psychometric characteristics were extracted from each study selected. Read More

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http://dx.doi.org/10.20945/2359-3997000000216DOI Listing

Cholestatic syndrome as initial manifestation of pancreatic metastasis of papillary thyroid carcinoma: case report and review.

Arch Endocrinol Metab 2020 Apr 27;64(2):179-184. Epub 2020 Mar 27.

Unidade de Endocrinologia Oncológica, Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, RJ, Brasil.

Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome. Read More

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http://dx.doi.org/10.20945/2359-3997000000215DOI Listing

The rs11755527 polymorphism in the BACH2 gene and type 1 diabetes mellitus: case control study in a Brazilian population.

Arch Endocrinol Metab 2020 Apr 27;64(2):138-143. Epub 2020 Mar 27.

Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.

Objective Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by a complex interaction between environmental and genetic risk factors. BTB domain and CNC homolog 2 (BACH2) gene encodes a transcription factor that acts on the differentiation and formation of B and T lymphocytes. BACH2 is also involved in the suppression of apoptosis and inflammation in pancreatic beta-cells, indicating a role for it in the development of T1DM. Read More

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http://dx.doi.org/10.20945/2359-3997000000214DOI Listing

Validation to Brazilian Portuguese of the Self-Care Inventory-revised for adults with type 2 diabetes.

Arch Endocrinol Metab 2020 Apr 27;64(2):190-194. Epub 2020 Mar 27.

Departamento de Medicina Interna, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Objective The aim of this study was to cross-culturally adapt and validate the Brazilian Portuguese version of SCI-R to adults with type 2 diabetes. Materials and methods The SCI-R is a 15-question survey that reflects how well patients with diabetes have adhered to treatment recommendations. A pretest (n = 40) was first performed to improve comprehension of the survey items. Read More

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http://dx.doi.org/10.20945/2359-3997000000213DOI Listing

Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment.

Arch Endocrinol Metab 2020 Apr 27;64(2):121-127. Epub 2020 Mar 27.

Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Objective To determine whether first-voided urinary LH (FV-ULH) - level measurement can adequately assess pubertal suppression as much as standard tests can. Subjects and methods The study group included patients with central precocious puberty and rapidly progressing early puberty who received up to 3 - 4 doses of GnRHa therapy monthly and did not have adequate hormonal suppression after GnRH stimulation (90-minute LH level > 4 IU/L). Design: All of the participants underwent an LHRH test just after admission to the study. Read More

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http://dx.doi.org/10.20945/2359-3997000000212DOI Listing

Primary hyperparathyroidism in developing world: a systematic review on the changing clinical profile of the disease.

Arch Endocrinol Metab 2020 Apr 27;64(2):105-110. Epub 2020 Mar 27.

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

While the developed world is focusing on laying guidelines for selecting out cases of Asymptomatic primary hyperparathyroidism (PHPT) for surgical intervention and promoting minimal access surgery, the developing world is observing a change in disease spectrum from advanced symptomatic to lesser degree of symptomatic disease and not many with associated Vitamin D deficiency. Few studies from the developing countries of the world have focused on the changing clinical spectrum of PHPT. Objective of this study is to review the changing profile of PHPT in developing world. Read More

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http://dx.doi.org/10.20945/2359-3997000000211DOI Listing

Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy.

Arch Endocrinol Metab 2020 Apr 27;64(2):144-149. Epub 2020 Mar 27.

Endocrinology Department, Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal.

Objectives Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). Subjects and methods Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. Read More

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http://dx.doi.org/10.20945/2359-3997000000210DOI Listing

Selective case finding versus universal screening for detecting hypothyroidism in the first trimester of pregnancy: a comparative evaluation of a group of pregnant women from Rio de Janeiro.

Arch Endocrinol Metab 2020 Apr 27;64(2):159-164. Epub 2020 Mar 27.

Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Objective Maternal hypothyroidism during pregnancy may lead to adverse outcomes. Recently published guidelines by the American Thyroid Association (ATA) do not advocate for universal screening but recommend a case-finding approach in high-risk pregnant women. The present study aims to evaluate the accuracy of this approach in identifying women with thyroid dysfunction during early pregnancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000209DOI Listing

EIF1AX c.338-2A>T splice site mutation in a patient with trabecular adenoma and cytological indeterminate lesion.

Arch Endocrinol Metab 2020 Apr 27;64(2):185-189. Epub 2020 Mar 27.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

The EIF1AX gene mutations have been recently associated with papillary thyroid carcinoma and anaplastic thyroid cancer. According with these reports, the gene as been considered as a drive gene for thyroid cancer development. However, the occurrence of these alterations in benign thyroid lesions is not known and is still under investigation. Read More

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http://dx.doi.org/10.20945/2359-3997000000208DOI Listing

Aspiration with or without lavage in the treatment of acute suppurative thyroiditis secondary to pyriform sinus fistula.

Arch Endocrinol Metab 2020 Apr 27;64(2):128-137. Epub 2020 Mar 27.

Department of Otolaryngology, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu, China.

Objective There is currently no consensus regarding the optimal management of acute suppurative thyroiditis (AST) secondary to pyriform sinus fistula (PSF). To investigate the benefits and adverse events of aspiration with or without lavage for the treatment of AST secondary to PSF. Subjects and methods This was a retrospective analysis of consecutive patients with AST secondary to PSF who were admitted at the Affiliated Changzhou No. Read More

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http://dx.doi.org/10.20945/2359-3997000000207DOI Listing

Tri-ponderal mass index and body mass index in prediction of pediatric metabolic syndrome: the CASPIAN-V study.

Arch Endocrinol Metab 2020 Apr 27;64(2):171-178. Epub 2020 Mar 27.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective Body mass index (BMI) and tri-ponderal mass index (TMI) are anthropometric measures to evaluate body adiposity in the various age groups. The present study aims to compare the predictive value of TMI and BMI for metabolic syndrome (Mets) in children and adolescents of both genders. Subjects and methods A cross-sectional study conducted on 3731 Iranian children and adolescents aged 7-18 years obtained from the fifth survey of 'Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease' (CASPIAN-V) study. Read More

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http://dx.doi.org/10.20945/2359-3997000000206DOI Listing

Evaluation of the application of the Diabetes Quality of Life Questionnaire in patients with diabetes mellitus.

Arch Endocrinol Metab 2020 Feb 13;64(1):59-65. Epub 2020 Mar 13.

Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brasil.

Objective Diabetes mellitus (DM) is a chronic disease with great impact on patients' quality of life (QoL). This variable can be measured using reliable, standardized, and validated instruments. The purpose of this study was to evaluate the application and reporting of the Diabetes Quality of Life Measure (DQOL) or the Diabetes Quality of Life for Youths Measure (DQOLY), an adapted version for young patients with DM. Read More

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http://dx.doi.org/10.20945/2359-3997000000196DOI Listing
February 2020

Polycystic ovary syndrome: new insights on the puzzle of adiposity, chronic low-grade inflammation and metabolic disturbances.

Arch Endocrinol Metab 2020 02 13;64(1):2-3. Epub 2020 Mar 13.

Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000205DOI Listing
February 2020

News for a New Year.

Arch Endocrinol Metab 2020 02 13;64(1). Epub 2020 Mar 13.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000204DOI Listing
February 2020

Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin.

Arch Endocrinol Metab 2020 Feb 13;64(1):4-10. Epub 2020 Mar 13.

Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Objective The aim of this study was to investigate polycystic ovary syndrome (PCOS) and to explore the relationship between body fat percentage and metabolic markers. Subjects and methods Sedentary women were assigned to PCOS (N = 60) and CONTROL (N = 60) groups. Each group was subdivided into three subgroups according to body fat percentage (22-27%, 27-32% and 32-37%). Read More

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http://dx.doi.org/10.20945/2359-3997000000197DOI Listing
February 2020

Insufficient iodine intake in pregnant women in different regions of the world: a systematic review.

Authors:

Arch Endocrinol Metab 2020 02 13;64(1):96. Epub 2020 Mar 13.

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http://dx.doi.org/10.20945/2359-3997000000202DOI Listing
February 2020

High-sugar diet leads to obesity and metabolic diseases in ad libitum -fed rats irrespective of caloric intake.

Arch Endocrinol Metab 2020 Feb 13;64(1):71-81. Epub 2020 Mar 13.

Programa de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil.

Objective Provide a comprehensive view of the events surrounding the sugar consumption, under conditions of energy equivalence; through the analysis of behavioral aspects of intake, and of biochemical, metabolic and physiological parameters, as well as the effect of this nutrient on the plasticity of adipose tissue. Materials and methods Newly weaned male Wistar rats were classified in two groups and subjected to the following normocaloric diets: standard chow diet or to high-sugar diet (HSD) ad libitum for 18 weeks. Results The animals submitted to the HSD were associated with a lower caloric intake during the 18 weeks of experimentation. Read More

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http://dx.doi.org/10.20945/2359-3997000000199DOI Listing
February 2020

Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition.

Arch Endocrinol Metab 2020 Feb 13;64(1):89-95. Epub 2020 Mar 13.

Departamento de Pós-Graduação em Distúrbios do Desenvolvimento, Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brasil.

Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Read More

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http://dx.doi.org/10.20945/2359-3997000000201DOI Listing
February 2020

Is biochemical hypoglycemia necessary during an insulin tolerance test?

Arch Endocrinol Metab 2020 Feb 13;64(1):82-88. Epub 2020 Mar 13.

Department of Endocrinology, Medical School, Erciyes University, Kayseri, Turkey.

Objective The insulin tolerance test (ITT) has been accepted as the gold standard test for assessing the integrity of the growth hormone (GH) - insulin-like growth factor (IGF-1) axis and the hypothalamic-pituitary-adrenal (HPA) axis. The goal of the test is to achieve clinical and biochemical hypoglycemia at a blood glucose level ≤ 40 mg/dL to effectively and correctly assess the HPA and GH-IGF-1 axes. In this study, the GH and cortisol responses of patients who achieved and failed to achieve biochemical hypoglycemia during an ITT were compared. Read More

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http://dx.doi.org/10.20945/2359-3997000000200DOI Listing
February 2020

Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients.

Arch Endocrinol Metab 2020 Feb 13;64(1):66-70. Epub 2020 Mar 13.

Biochemistry Department, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.

Objective Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Read More

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http://dx.doi.org/10.20945/2359-3997000000198DOI Listing
February 2020

The position of combined medical treatment in acromegaly.

Arch Endocrinol Metab 2019 Nov-Dec;63(6):646-652

Department of Medicine, Section Endocrinology, Pituitary Center Rotterdam, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Advances in combination medical treatment have offer new perspectives for acromegaly patients with persistent disease activity despite receiving the available medical monotherapies. The outcomes of combination medical treatment may reflect both additive and synergistic effects. This review focuses on combination medical treatment and its current position in acromegaly, based on clinical studies evaluating the efficacy and safety of combined medical treatment(s) and our own experiences with combination therapy. Read More

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http://dx.doi.org/10.20945/2359-3997000000195DOI Listing
February 2020

Acromegaly in the elderly patient.

Arch Endocrinol Metab 2019 Nov-Dec;63(6):638-645

Unidade de Neuroendocrinologia, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Acromegaly is an insidious disease, usually resulting from growth hormone hypersecretion by a pituitary adenoma. It is most often diagnosed during the 3rd to 4th decade of life. However, recent studies have shown an increase in the incidence and prevalence of acromegaly in the elderly, probably due to increasing life expectancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000194DOI Listing
February 2020

Determinants of morbidities and mortality in acromegaly.

Arch Endocrinol Metab 2019 Nov-Dec;63(6):630-637

Centro de Pesquisa em Neuroendocrinologia, Divisão de Endocrinologia, Faculdade de Medicina e Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Acromegaly is a systemic disease associated with increased morbidity, presenting cardiovascular, metabolic, respiratory, neoplastic, endocrine, articular and bone complications. Most of these comorbidities can be prevented or delayed with adequate disease treatment and, more recent studies with the use of modern treatments of acromegaly, have shown a change in the severity and prevalence of these complications. In addition, acromegaly is associated with increased mortality, but recent studies (especially those published in the last decade) have shown a different scenario than older studies, with mortality no longer being increased in adequately controlled patients and a change in the main cause of death from cardiovascular disease to malignancy. Read More

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http://dx.doi.org/10.20945/2359-3997000000193DOI Listing
February 2020

Laboratory investigations in the diagnosis and follow-up of GH-related disorders.

Arch Endocrinol Metab 2019 Nov-Dec;63(6):618-629

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.

In addition to auxiological, clinical and metabolic features measurements of growth hormone (GH) and insulin-like growth factor I (IGF-I) complement our tools in diagnosis and follow-up of GH-related disorders. While comparably robust during the pre-analytical phase, measurement and interpretation of concentrations of both hormones can be challenging due to analytical issues and biological confounders. Assay methods differ in terms of antibody specificity, interference from binding proteins, reference preparations and sensitivity. Read More

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http://dx.doi.org/10.20945/2359-3997000000192DOI Listing
February 2020