Biological characterization of wild-bird-origin avian avulavirus 1 and efficacy of currently applied vaccines against potential infection in commercial poultry.
- Rania F El Naggar,
- Mohammed A Rohaim,
- AbdelHamid H Bazid,
- Kawkab A Ahmed,
- Hussein A Hussein,
- Muhammad Munir
Arch Virol 2018 Jun 19. Epub 2018 Jun 19.
The Pirbright Institute, Ash Road, Woking, Surrey, GU24 0NF, UK.
Newcastle disease virus (NDV), the type member of the species Avian avulavirus 1 (formerly known as avian paramyxovirus serotype 1), causes a highly contagious and economically important disease in a myriad of avian species around the globe. While extensive vaccination programs have been implemented in ND-endemic countries, the disease is continuously spreading in commercial, backyard, and wild captive poultry. In order to investigate the evolution of the virus and assess the efficiency of the vaccine regimens that are currently being applied in commercial poultry, four wild-bird-origin NDV strains were characterized biologically, based on mean death time and intracerebral pathogenicity index, and genetically, based on the cleavage motif (RRQKRF) in the fusion (F) protein. Read More