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    8934 results match your criteria Archives of Oral Biology[Journal]

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    The chemokine receptor type 4 antagonist, AMD3100, interrupts experimental tooth movement in rats.
    Arch Oral Biol 2017 Nov 11;86:35-39. Epub 2017 Nov 11.
    Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
    Objective: The aim of this study was to clarify the role of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis in osteoclast accumulation, and the influence of orthodontic tooth movement (OTM) under mechanical force application to periodontal tissues, by administration of the CXCR4 antagonist AMD3100.

    Design: The upper right first molar (M1) of rats was moved mesially with a 10-g force titanium-nickel closed coil spring. Rats were treated with phosphate-buffered saline or AMD3100 (5mg/kg), which is a SDF-1 antagonist. Read More

    The risk factors related to bruxism in children: A systematic review and meta-analysis.
    Arch Oral Biol 2017 Nov 11;86:18-34. Epub 2017 Nov 11.
    Department of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, No. 199 Dong Gang West Road, Gansu, China; Gansu Provincial Maternity and Child Care Hospital, No. 143 North Road, Gansu, China.
    Objective: This systematic review was performed to determine the risk factors related to bruxism in children.

    Design: This systematic review was conducted with reporting in agreement to the PRISMA statement and according to guidelines from the Cochrane Handbook for Systematic Reviews of Interventions. We conducted a systematic search of seven online databases, with the last search updated on 1st October 2016. Read More

    Risk factors for tooth loss in middle and older age after up to 10 years: An observational cohort study.
    Arch Oral Biol 2017 Nov 6;86:7-12. Epub 2017 Nov 6.
    Dental School, Department of Prosthetic Dentistry, University of Heidelberg, Germany.
    Objective: The objective of this research was to identify risk factors for tooth loss in two birth cohorts, quinquagenarians and septuagenarians, after up to 10 years of clinical observation.

    Design: One hundred and twenty-three participants were recruited from the Interdisciplinary Study of Adult Development (ILSE) and examined at baseline and up to 10 years after. Thirty-nine and 84 participants belonged to the older (OC; born in 1930/32) cohort and younger (YC; born in 1950/52) cohort, respectively. Read More

    Secretoneurin and PE-11 immunoreactivity in the human dental pulp.
    Arch Oral Biol 2017 Nov 9;86:13-17. Epub 2017 Nov 9.
    Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
    Objective: To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin gene-related peptide were performed to confirm the sensory origin of the peptidergic nerves in the dental pulp.

    Design: The concentrations of secretoneurin and PE-11 were determined by highly sensitive radioimmunoassays in extracts of dental pulps, the molecular form of secretoneurin immunoreactivities by RP-HPLC with subsequent radioimmunoassay and colocalization studies with calcitonin gene-related peptide were performed by double immunofluorescence. Read More

    Regionally variant collagen alignment correlates with viscoelastic properties of the disc of the human temporomandibular joint.
    Arch Oral Biol 2017 Nov 8;86:1-6. Epub 2017 Nov 8.
    Regenerative Engineering Laboratory, Section for Oral and Maxillofacial Surgery, College of Dental Medicine, Columbia University, 630 W. 168 St. - VC12-230, New York, NY 10032, United States. Electronic address:
    Objective: To determine the regionally variant quality of collagen alignment in human TMJ discs and its statistical correlation with viscoelastic properties.

    Design: For quantitative analysis of the quality of collagen alignment, horizontal sections of human TMJ discs with Pricrosirius Red staining were imaged under circularly polarized microscopy. Mean angle and angular deviation of collagen fibers in each region were analyzed using a well-established automated image-processing for angular gradient. Read More

    Selection in mixtures of food particles during oral processing in man.
    Arch Oral Biol 2017 Oct 31;85:212-225. Epub 2017 Oct 31.
    The Dental School, University of Dundee, Dundee, Scotland, UK.
    Objectives: Two processes underlie food comminution during chewing: (1) selection, i.e. every particle has a chance of being placed between the teeth and being subjected to (2) breakage. Read More

    Nitric oxide and arginase levels in peri-implant tissues after delayed loading.
    Arch Oral Biol 2017 Oct 23;85:207-211. Epub 2017 Oct 23.
    Ankara University Faculty of Medicine Department of Biochemistry 06100 Ankara, Turkey. Electronic address:
    Objective: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS). Arginase can compete with NOS for the common substrate L-arginine, and thus inhibit NO production. NO levels and arginase ezyme might affect the bone remodeling cycle around implants. Read More

    Histamine stimulates secretion of extracellular vesicles with nucleotidase activity in rat submandibular gland.
    Arch Oral Biol 2017 Oct 18;85:201-206. Epub 2017 Oct 18.
    Universidad de Buenos Aires, Facultad de Odontología,C átedra de Farmacología, M. T. de Alvear 2142, Ciudad Autónoma de Buenos Aires, 1122, Argentina.
    Background: Extracellular vesicles released by different cells have been isolated from diverse fluids including saliva. We previously reported that rat submandibular glands secrete nanovesicles that catalyze hydrolysis of ATP, ADP and AMP, which are actors of the purinergic signaling system along with adenosine. Extracellular nucleotides like ATP and adenosine are involved in the regulation of inflammatory processes and apoptosis. Read More

    Presence of dental signs of congenital syphilis in pre-modern specimens.
    Arch Oral Biol 2017 Oct 20;85:192-200. Epub 2017 Oct 20.
    Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, Adelaide Medical School,Frome Road, Adelaide, 5005, South Australia, Australia; Institute of Evolutionary Medicine, University of Zurich, Switzerland.
    Objective: Tooth morphology can vary due to genetic factors, infectious diseases and other environmental stresses. Congenital syphilis is known to interrupt tooth formation i.e. Read More

    Three-dimensional mammalian tooth development using diceCT.
    Arch Oral Biol 2017 Oct 20;85:183-191. Epub 2017 Oct 20.
    School of Biological Sciences, 18 Innovation Walk, Monash University, Victoria 3800, Australia; Geosciences, Museums Victoria, Melbourne, Victoria 3001, Australia.
    Objective: This study aims to develop the Diffusible Iodine-based Contrast-Enhanced CT (diceCT) method for non-destructive imaging of both soft and mineralised tissues. We sought to document the 3D spatio-temporal pattern of mammalian tooth development including multiple tooth classes and generations, using the tammar wallaby (Macropus eugenii) as a model species.

    Design: We took microCT scans of developing fetuses and pouch young stained using Lugol's Iodine (I2KI) contrast agent. Read More

    Lupinifolin from Albizia myriophylla wood: A study on its antibacterial mechanisms against cariogenic Streptococcus mutans.
    Arch Oral Biol 2017 Oct 18. Epub 2017 Oct 18.
    Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
    Objective: To determine the anti-Streptococcus mutans mechanisms of action of lupinifolin from Albizia myriophylla Benth. (Fabaceae) wood and provide scientific evidence to support the traditional use of the plant against dental caries.

    Methods: The minimum inhibitory concentration (MIC) was evaluated using the broth micro-dilution method. Read More

    Evaluation of the bisphosphonate effect on stem cells derived from jaw bone and long bone rabbit models: A pilot study.
    Arch Oral Biol 2017 Oct 31;85:178-182. Epub 2017 Oct 31.
    Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Institute of Foreign Language Studies, Korea University, Seoul, Republic of Korea.
    Background And Objective: Bisphosphonates have been widely used and the number of patients experiencing medication-related osteonecrosis of the jaw (MRONJ) has been increasing. This study was designed to evaluate the effect of zoledronate on stem cells derived from different tissues.

    Design: Stem cells derived from four different tissues were compared using rabbit models (JPO: periosteum from the jaw bone (mandible), JBM: bone marrow from the jaw bone, LPO: periosteum from long bone (tibia), and LBM: bone marrow from long bone). Read More

    L-mimosine and hypoxia enhance angiopoietin-like 4 production involving hypoxia-inducible factor-1alpha: Insights from monolayer and spheroid cultures of dental pulp-derived cells and tooth slice cultures.
    Arch Oral Biol 2017 Oct 16;85:172-177. Epub 2017 Oct 16.
    Department of Conservative Dentistry and Periodontology, School of Dentistry, Medical University of Vienna, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address:
    Objective: Angiopoietin-like 4 (Angptl4) is an angiogenesis modulating signaling factor and as such involved in blood vessel formation but also in hard tissue resorption. Here we hypothesized that the hypoxia mimetic agent L-mimosine (L-MIM) and hypoxia stimulate the production of Angptl4 in the dental pulp.

    Material And Methods: Monolayer and spheroid cultures of primary human dental pulp-derived cells (DPC) were treated with L-MIM or hypoxia. Read More

    Effectiveness of three age estimation methods based on dental and skeletal development in a sample of young Brazilians.
    Arch Oral Biol 2017 Oct 18;85:166-171. Epub 2017 Oct 18.
    Department of Dentistry, Federal University of Sergipe (UFS), Lagarto, SE, Brazil. Electronic address:
    Objective: This study compared three methods designed for age estimation.

    Methods: A sample of 468 radiographs (234 panoramic and 234 carpal radiographs) collected from patients ranging from 5 to 14 years old (mean age: 11.27years old±2. Read More

    A novel 18-bp in-frame deletion mutation in RUNX2 causes cleidocranial dysplasia.
    Arch Oral Biol 2017 Oct 27. Epub 2017 Oct 27.
    Department Prosthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, PR China. Electronic address:
    Objectives: Runt-related transcription factor 2 (RUNX2) gene is known to cause rare autosomal dominant skeletal disorder Cleidocranial dysplasia (CCD). Here, we explored a novel, large deletion in RUNX2 gene in a Chinese patient with CCD and the function associated with the mutation.

    Design: Genomic DNA was extracted from the peripheral blood and subjected to do DNA sequencing. Read More

    The effects of storage time and temperature on the stability of salivary phosphatases, transaminases and dehydrogenase.
    Arch Oral Biol 2017 Oct 20;85:160-165. Epub 2017 Oct 20.
    Department of Basic Sciences, São Paulo State University (Unesp), School of Dentistry, Araçatuba, Rodovia Marechal Rondon 527/528 km, Campus Universitário, CEP 16018-805, São Paulo, Brazil; Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas - SBFis, São Paulo State University (Unesp), School of Dentistry, Rodovia Marechal Rondon 527/528 km, Campus Universitário, CEP 16018-805, São Paulo, Brazil. Electronic address:
    Objectives: To investigate the influence of temperature and storage time on salivary acid phosphatase (ACP), tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and lactate dehydrogenase (LDH).

    Design: Unstimulated whole expectorated saliva was collected from healthy men and women subjects (n=26) between 8 and 10a.m. Read More

    Effect of chronic stress on capsaicin-induced dental nociception in a model of pulpitis in rats.
    Arch Oral Biol 2017 Oct 18;85:154-159. Epub 2017 Oct 18.
    Oral and Dental Diseases Research Center/Kerman Social Determinants on Oral Health Research Center, Kerman University of Medical Sciences, Kerman, Iran.
    Objective: Chronic stress can alter nociceptive sensitivity. However, the effect of stress exposure on dental nociception has been less addressed. Therefore, the present study investigated the effects of chronic exposures to some social and psychological stresses on pulpal nociceptive responses. Read More

    Dipeptidyl peptidase-4 inhibitor enhances restoration of salivary glands impaired by obese-insulin resistance.
    Arch Oral Biol 2017 Oct 20;85:148-153. Epub 2017 Oct 20.
    Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:
    Objective: Chronic high-fat diet consumption causes not only obese- insulin resistance, but also leads to pathological changes in salivary glands, including increased mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. Dipeptidyl peptidase-4 inhibitor (vildagliptin) is an oral anti-diabetic drug, using for treatment of type 2 diabetes. Vildagliptin has been shown to exert beneficial effects on several organs in cases of obese-insulin resistant condition. Read More

    Evidence for programmed odontoblast process retraction after dentine exposure in the rat incisor.
    Arch Oral Biol 2017 Oct 10;85:130-141. Epub 2017 Oct 10.
    Urology and Urological Rehabilitation Antwerp University, Belgium. Electronic address:
    Objective: To re-examine the morphology and potential functions of odontoblasts in intact rat incisors and after cavity preparation into dentine.

    Design: Intact incisors were fixed, decalcified, snap frozen and sectioned (10μm), before staining with rhodamine phalloidin or antibodies for cyto-skeletal proteins: vimentin and actin, ion transporter: NaK-ATPase, and dendritic cell marker: OX6. Samples with cavity were processed similarly and stained for actin and vimentin before comparing the lengths of odontoblast processes (OP) at baseline, 3h and 24h (n=5 for each group). Read More

    Interferon regulatory factor 6 variants affect nasolabial morphology in East Asian populations.
    Arch Oral Biol 2017 Oct 9;85:142-147. Epub 2017 Oct 9.
    Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address:
    Objective: The interferon regulatory factor 6 gene (IRF6) is one of the most conspicuous genes among a large number of candidate risk genes for non-syndromic cleft lip with or without cleft palate, which is considered to be a multifactorial defect. Variants of IRF6 are also suggested to affect normal craniofacial variations, especially in the area of the nose and the upper lip. In the present study, we used lateral cephalograms to establish the relationship between IRF6 and sagittal nasolabial morphology in healthy East Asian subjects. Read More

    Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model.
    Arch Oral Biol 2017 Oct 16;85:120-129. Epub 2017 Oct 16.
    Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.
    Objective: The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis.

    Design: CMIDF inserts were fabricated by the solvent casting technique. The fabricated inserts were evaluated for physical characteristics such as folding endurance, surface pH, mucoadhesive strength, metformin content uniformity, and release. Read More

    Antibacterial activity against cariogenic bacteria and cytotoxic and genotoxic potential of Anacardium occidentale L. and Anadenanthera macrocarpa (Benth.) Brenan extracts.
    Arch Oral Biol 2017 Oct 14;85:113-119. Epub 2017 Oct 14.
    Department of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil. Electronic address:
    Objectives: The present study aimed to assess the antibacterial activity against bacteria with cariogenic relevance, toxic and genotoxic potential of the plants Anacardium occidentale L. and Anadenanthera macrocarpa (Benth.) Bernam. Read More

    Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.
    Arch Oral Biol 2017 Sep 29;85:98-103. Epub 2017 Sep 29.
    Department of Biotechnology and Life Science, Koganei, Tokyo 184-8588, Japan; Global Innovation Research Organization Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan. Electronic address:
    Objective: Periodontitis is characterized by local inflammation leading to tooth loss and severe destruction of alveolar bone. Raloxifene is a selective estrogen receptor modulator (SERM) that halts estrogen deficiency-induced systemic bone loss in postmenopausal osteoporosis without the side effects of cancer in breast and uterus. In this study, we examined the effects of raloxifene on alveolar bone mass in a mouse model with estrogen deficiency-induced periodontitis. Read More

    Multiple complex somatosensory systems in mature rat molars defined by immunohistochemistry.
    Arch Oral Biol 2017 Sep 29;85:84-97. Epub 2017 Sep 29.
    Department of Anesthesiology & Pain Medicine, Box 356540, University of Washington, Seattle, WA 98195-6540, USA.
    Objective: Intradental sensory receptors trigger painful sensations and unperceived mechanosensitivity, but the receptor bases for those functions are only partly defined. We present new evidence here concerning complex endings of myelinated axons in rat molars.

    Design: We sectioned mature rat jaws in sagittal and transverse planes to analyze neural immunoreactivity (IR) for parvalbumin, peripherin, neurofilament protein, neurotrophin receptors, synaptophysin, calcitonin gene-related peptide (CGRP), or mas-related g-protein-receptor-d (Mrgprd). Read More

    Cdc42 is essential for the polarized movement and adhesion of human dental pulp stem cells.
    Arch Oral Biol 2017 Oct 3;85:104-112. Epub 2017 Oct 3.
    State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi Province, PR China. Electronic address:
    Objective: Stem cell-based tissue repair and regeneration require the regulation of cell migration and adhesion. As a regulator of cell polarization, Cdc42 (cell division control protein 42) plays a basic role at the initial stage of cell migration and adhesion. This study explores the effect of Cdc42 on the polarized migration and adhesion of hDPSCs (human dental pulp stem cells). Read More

    Cytokine profile changes in gingival crevicular fluid after placement different brackets types.
    Arch Oral Biol 2017 Sep 25;85:79-83. Epub 2017 Sep 25.
    Department of Pediatric Clinic, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
    Objective: The aim of this study was to examine the relationship between bracket design and ratio of five proinflammatory cytokine, in gingival crevicular fluid (GCF), and bacterial adhesion without tooth movement influence.

    Design: The sample was comprised of 20 participants, aged 11 to 15 years old (mean age: 13.3 years±1. Read More

    Reactivation of peroxidase activity in human saliva samples by polyphenols.
    Arch Oral Biol 2017 Oct 7;85:70-78. Epub 2017 Oct 7.
    Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstraße 16-18, 04107 Leipzig, Germany. Electronic address:
    Objectives: The enzyme lactoperoxidase (LPO), which is released into several body fluids like saliva, is an essential part to maintain the oral bacterial homeostasis by catalysing the oxidation of thiocyanate (SCN(-)) to hypo-thiocyanite ((-)OSCN). The formation of unreactive redox intermediates (like Compound II) leads to a decreased pseudo-halogenating enzyme activity, which is associated with a higher risk for oral infections. According to former studies with bovine LPO selected flavonoids were tested in respect to their potential to reactivate the enzymatic activity in a more physiological, human salivary system. Read More

    Colonization of oropharynx and lower respiratory tract in critical patients: Risk of ventilator-associated pneumonia.
    Arch Oral Biol 2017 Oct 2;85:64-69. Epub 2017 Oct 2.
    Institute of Science and Technology, UNESP - Univ Estadual Paulista, Av. Eng. Francisco José Longo, 777, Jd São Dimas, São José dos Campos, São Paulo, Brazil.
    Objective: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied. The last objective was to analyses correlation between blood cultures and VAP. Read More

    Probiotic intervention influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults.
    Arch Oral Biol 2017 Oct 7;85:58-63. Epub 2017 Oct 7.
    Institute of Dentistry, University of Turku, Finland.
    Objective: To study the effect of orally administered Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG on the salivary levels of Matrix Metalloproteinases (MMP)-8, MMP-9 and of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in healthy adults. Furthermore, the correlations between MMP-8, MMP-9 and TIMP-1 and plaque and gingival indices, salivary mutans streptococci and lactobacilli counts, and stimulated saliva secretion rate were analysed. Read More

    The effect of supragingival biofilm re-development on the subgingival microbiota in chronic periodontitis.
    Arch Oral Biol 2017 Oct 10;85:51-57. Epub 2017 Oct 10.
    School of Dentistry, Department of Clinics, Rio de Janeiro, RJ, Brazil; Institute of Microbiology, Department of Medical Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:
    Objective: In this study, we hypothesized that in the absence of oral hygiene, re-growth of the climax microbial communities of supra and subgingival biofilm happens in a faster and more intense fashion in individuals with chronic periodontitis (CP) compared to periodontally healthy controls (PH).

    Design: Thirty patients (PH=15 and CP=15) received professional supragingival prophylaxis, and were asked to refrain from oral hygiene for 7days. Supra and subgingival biofilm samples and GCF were collected from randomly selected quadrants at baseline (before prophylaxis), immediately after prophylaxis, 2h, 6h, 24h, and 7days after prophylaxis. Read More

    Novel methodology for determining the effect of adsorbates on human enamel acid dissolution.
    Arch Oral Biol 2017 Oct 3;85:46-50. Epub 2017 Oct 3.
    Department of Oral Biology, School of Dentistry, Wellcome Trust Brenner Building, St. James's University Hospital, University of Leeds, Leeds, LS9 7TF, UK. Electronic address:
    Objective: The effect of various interventions on enamel demineralisation can be determined by chemically measuring mineral ions dissolved by the attacking acid. Results are usually expressed as mineral loss per surface area of enamel exposed. Acid resistant varnish or adhesive tape are typically used to delineate an area of enamel. Read More

    Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm.
    Arch Oral Biol 2017 Oct 6;85:40-45. Epub 2017 Oct 6.
    Department of Otorhinolaryngology, Division of Phoniatrics-Logopedics, Medical University of Vienna, Vienna, Austria.
    Objectives: Oral candidiasis is one of the most common human fungal infections. While most cases of the Candida species isolated from the oral cavity are Candida albicans, a large number of candidiasis is attributed to non-albicans Candida species. In this study, we aim to evaluate the in vitro inhibition of supernatants of Lactobacillus gasseri and Lactobacillus rhamnosus on the single and mixed species biofilm of non-albicans Candida species, including Candida tropicalis, Candida krusei and Candida parapsilosis. Read More

    Homeobox genes and tooth development: Understanding the biological pathways and applications in regenerative dental science.
    Arch Oral Biol 2017 Oct 4;85:23-39. Epub 2017 Oct 4.
    Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:
    Objectives: Homeobox genes are a group of conserved class of transcription factors that function as key regulators during the embryonic developmental processes. They act as master regulator for developmental genes, which involves coordinated actions of various auto and cross-regulatory mechanisms. In this review, we summarize the expression pattern of homeobox genes in relation to the tooth development and various signaling pathways or molecules contributing to the specific actions of these genes in the regulation of odontogenesis. Read More

    EZH2 regulates dental pulp inflammation by direct effect on inflammatory factors.
    Arch Oral Biol 2017 Oct 7;85:16-22. Epub 2017 Oct 7.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:
    Objective: Pulpitis is a multi-factorial disease that could be caused by complex interactions between genetics, epigenetics and environmental factors. We aimed to evaluate the role of Enhancer of Zeste Homolog 2 (EZH2) in the inflammatory response of human dental pulp cells (HDPCs) and dental pulp tissues.

    Methods: The expressions of inflammatory cytokines in HDPCs treated by EZH2 complex or EZH2 siRNA with or without rhTNF-α were examined by quantitative real-time polymerase chain reaction (q-PCR). Read More

    A dual energy micro-CT methodology for visualization and quantification of biofilm formation and dentin demineralization.
    Arch Oral Biol 2017 Oct 7;85:10-15. Epub 2017 Oct 7.
    Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:
    Objective: The aim of this study was to induce artificial caries in human sound dentin by means of a microcosm model using human saliva as source of bacteria and to apply a novel dual-energy micro-CT technique to quantify biofilm formation and evaluate its demineralization potential.

    Design: Eight sound third molars had the occlusal enamel removed by cutting with a diamond disk and five cylindrical cavities (±2mm diameter; ±1.5mm depth) were prepared over the dentin surface in each specimen (n=40 cavities). Read More

    Role of PDGF-BB in proliferation, differentiation and maintaining stem cell properties of PDL cells in vitro.
    Arch Oral Biol 2017 Sep 25;85:1-9. Epub 2017 Sep 25.
    Medical University Sofia, Dept. of Medical Chemistry and Biochemistry, 2 Zdrave Str., Sofia, Bulgaria. Electronic address:
    Objective: Platelet-derived growth factor-BB (PDGF-BB) is one of the most abundant growth factors in platelet derived products and has been shown to stimulate regeneration after tissue injury. There is a population of mesenchymal stem cells (MSC) in human periodontal ligament (PDL) which can contribute to tissue regeneration under appropriate conditions.

    Design: PDL cells were isolated and characterized using stem cell and differentiation markers via immunofluorescence and flow cytometry and then cultured in vitro and treated with different concentrations of PDGF-BB. Read More

    Overexpression of constitutively active MAP3K7 in ameloblasts causes enamel defects of mouse teeth.
    Arch Oral Biol 2017 Dec 25;84:169-175. Epub 2017 Sep 25.
    Department of Stomatology, Hospital Affiliated to Binzhou Medical University, Binzhou City, Shandong Province 256603, People's Republic of China. Electronic address:
    Objective: Compelling evidence suggests that mitogen-activated protein kinases (Mapks) play an important role in amelogenesis. However, the role of transforming growth factor (TGF)-β-activating kinase 1 (Tak1, Map3k7), which is a known upstream kinase of Mapks, during amelogenesis remains to be determined. The aim of this study was to investigate the possible involvement of Map3k7 in amelogenesis. Read More

    Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis.
    Arch Oral Biol 2017 Dec 2;84:161-168. Epub 2017 Oct 2.
    College of Stomatology, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing, China. Electronic address:
    Objective: To investigate the association between the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and the IRF6 rs2235371 (C>T) polymorphism in Chinese Han populations.

    Design: PubMed, Web of Science and EMBASE were searched through May 31, 2016, to select eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were applied to estimate the risk of NSCL/P associated with the IRF6 rs2235371 polymorphism. Read More

    Tooth damage in captive orcas (Orcinus orca).
    Arch Oral Biol 2017 Dec 29;84:151-160. Epub 2017 Sep 29.
    Department of Oral Sciences, Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin 9054, New Zealand. Electronic address:
    Objectives: Tooth damage as a result of oral stereotypies is evident in captive orca, yet little research on the topic exists. This study examines the associations between dental pathology, sex, facility, duration of captivity and other factors in captive orca.

    Design: We evaluated mandibular and maxillary teeth from dental images of 29 captive orca owned by a US-based theme park. Read More

    Association of tongue brushing with the number of fungiform taste buds and taste perception: A preliminary study using confocal laser scanning microscopy in combination with a filter-paper disc method.
    Arch Oral Biol 2017 Dec 28;84:145-150. Epub 2017 Sep 28.
    Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Japan. Electronic address:
    Objective: The aim of this study was to investigate the association of tongue brushing with the number of fungiform taste buds and taste perception using a confocal laser scanning microscopy in combination with a filter-paper disc method (FPDM).

    Methods: Twenty-four subjects with or without a habit of tongue brushing (11 males and 13 females, 20-46 years old) participated in this study. Nine of the 24 subjects had no habit of tongue brushing (Group 1, n=9). Read More

    The effect of restorative materials on cytokines in gingival crevicular fluid.
    Arch Oral Biol 2017 Dec 27;84:139-144. Epub 2017 Sep 27.
    Department of Restorative Dentistry, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.
    Objective: Composition of the restorative materials may cause inflammatory responses by monocyte activation and changes in the levels of cytokine released from different cells. Interleukin-6 (IL-6), interleukin-8 (IL-8) and Tumor necrosis factor alpha (TNF-α) are important cytokine for evaluating of the inflammatory process. The aim of this study was to evaluate the different restorative materials used in class V cavities effect on gingival crevicular fluid inflammatory cytokine levels. Read More

    Inhibition of malodorous gas formation by oral bacteria with cetylpyridinium and zinc chloride.
    Arch Oral Biol 2017 Dec 28;84:133-138. Epub 2017 Sep 28.
    Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. Electronic address:
    Objective: The antimicrobial efficacy of zinc- (ZnCl2) and cetylpyridinium-chloride (CPC) and their inhibition capacity on volatile sulfur compound (VSC) production by oral bacterial strains were investigated.

    Design: Minimum inhibitory concentrations (MIC) and growth curves were determined for ZnCl2, CPC, and CPC with ZnCl2 solutions against eight oral microorganisms (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Tannerella forsythia, Staphylococcus aureus and Streptococcus mutans) known to be involved in the pathophysiology of both halitosis and periodontal disease. Gas chromatography was applied to measure VSCs (H2S, CH3SH, (CH3)2S) production levels of each strains following exposure to the solutions. Read More

    Mechanical and hypoxia stress can cause chondrocytes apoptosis through over-activation of endoplasmic reticulum stress.
    Arch Oral Biol 2017 Dec 25;84:125-132. Epub 2017 Sep 25.
    Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address:
    Objective: To examine the role of mechanical force and hypoxia on chondrocytes apoptosis and osteoarthritis (OA)-liked pathological change on mandibular cartilage through over-activation of endoplasmic reticulum stress (ERS).

    Methods: We used two in vitro models to examine the effect of mechanical force and hypoxia on chondrocytes apoptosis separately. The mandibular condylar chondrocytes were obtained from three-week-old male Sprague-Dawley rats. Read More

    Effect of Proanthocyanidin-enriched extracts on the inhibition of wear and degradation of dentin demineralized organic matrix.
    Arch Oral Biol 2017 Dec 25;84:118-124. Epub 2017 Sep 25.
    Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry - University of São Paulo, Bauru, SP, Brazil. Electronic address:
    Objectives: The aim of this study was to evaluate the effect of Cranberry and Grape seed-enriched extract gels in inhibiting wear and degradation of demineralized organic matrix (DOM).

    Design: 225 dentin specimens obtained from bovine incisors were randomly allocated into 5 groups (n=45): 10% Grape seed extract gel (GSE), 10% Cranberry extract gel (CE), 0.012% Chlorhexidine gel (CX), 1. Read More

    Evaluation of interleukin-10 producing CD19(+) B cells in human gingival tissue.
    Arch Oral Biol 2017 Dec 18;84:112-117. Epub 2017 Sep 18.
    The Fourth Hospital of Harbin Medical University, Harbin, 150001, China.
    Objective: This study aimed to evaluate IL-10 producing CD19(+) B cells and to examine the correlation between these cells and the expression levels of IL-1β, TNF-α, RANKL, and IL-10 cytokines in the gingival tissues of individuals with and without chronic periodontitis.

    Design: Data were obtained from 20 patients with chronic periodontitis and 10 healthy controls. The gingival samples were analyzed by immunofluorescence, while real-time PCR and enzyme-linked immunosorbent assays were performed to determine cytokine levels. Read More

    Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules.
    Arch Oral Biol 2017 Dec 25;84:106-111. Epub 2017 Sep 25.
    Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
    Objective: To analyze the anti-inflammatory and analgesic effects of an adhesive resin containing indomethacin-loaded nanocapsules in rat model.

    Design: Adhesive resin disks with or without indomethacin-loaded nanocapsules were subcutaneously implanted into right hind paw of rats. A week after surgical procedure, 2% formalin solution was intradermally injected into plantar surface of paw. Read More

    Apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: Involvement of Puma and Bax activation.
    Arch Oral Biol 2017 Dec 25;84:94-99. Epub 2017 Sep 25.
    Department of Oral Pathology, School of Dentistry, and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:
    Objective: Caffeic acid phenethyl ester (CAPE), a natural honeybee product exhibits a spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant and antitumor actions. The purpose of this research was to investigate the anticancer potential of CAPE and its molecular mechanism in human oral cancer cell lines (YD15, HSC-4 and HN22 cells).

    Design: To determine the apoptotic activity of CAPE and identify its molecular targets, trypan blue exclusion assay, soft agar assay, Western blot analysis, DAPI staining, and live/dead assay were performed. Read More

    Cytotoxicity, genotoxicity and antibacterial activity of poly(vinyl alcohol)-coated silver nanoparticles and farnesol as irrigating solutions.
    Arch Oral Biol 2017 Dec 25;84:89-93. Epub 2017 Sep 25.
    Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.
    Objective: To evaluate the cytotoxicity, genotoxicity and antibacterial activity of poly(vinyl alcohol)-coated silver nanoparticles (AgNPs-PVA) and farnesol (FAR).

    Design: The cytotoxicity (% of cell viability) was evaluated by MTT assay and the genotoxicity (% of DNA in the tail) was evaluated by Comet assay. Root canal disinfection with different irrigating protocols was evaluated ex vivo in human teeth contaminated with Enterococcus faecalis for 21days. Read More

    A novel PAX9 mutation causing oligodontia.
    Arch Oral Biol 2017 Dec 25;84:100-105. Epub 2017 Sep 25.
    Department of Physiology and Biochemistry, Medical School, University of Malta, Tal-Qroqq, Msida, MSD2020, Malta. Electronic address:
    Introduction: An extended family presenting with several members affected by developmentally missing teeth was investigated by analysis of the MSX1 and PAX9 genes.

    Materials And Methods: Saliva samples were collected and DNA extracted. Primers were designed to span the exons and intron-exon junctions of the MSX1 and PAX9 genes. Read More

    Acid-producing capacity from sugars and sugar alcohols among Lactobacillus isolates collected in connection with radiation therapy.
    Arch Oral Biol 2017 Dec 21;84:82-88. Epub 2017 Sep 21.
    Department of Oral Prosthetics, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Sweden.
    Objective: To investigate the acid-producing capacity from sugars and sugar alcohols of oral Lactobacillus collected in connection with radiation therapy (RT) to the head and neck region.

    Design: Lactobacillus were collected from the tongue, buccal mucosa and supragingival plaque in 24 patients before, during, and after RT. The acid-producing capacity of Lactobacillus isolates (n=211) was analyzed using a colorimetric fermentation test in microtiter plates. Read More

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