9,308 results match your criteria Archives of Oral Biology[Journal]


Histopathological and biochemical evaluation of the effect of Paeoniflorin on the periodontium during and after periodontitis formation in rats.

Arch Oral Biol 2019 Apr 12;102:135-140. Epub 2019 Apr 12.

Department of Periodontology, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey.

Objectives: Appraise the effect of systemic Paeoniflorin (Pae) application on the periodontium during and after induction of experimental periodontitis in the presence of ligature and after its removal.

Design: Seventy male Wistar rats were separated into seven equal groups. The first group was reserved as healthy control group (Group 1: no periodontitis, no medication) and experimental periodontitis was induced with ligature in the remaining rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183074
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http://dx.doi.org/10.1016/j.archoralbio.2019.04.006DOI Listing
April 2019
1 Read

MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study.

Arch Oral Biol 2019 Apr 15;102:128-134. Epub 2019 Apr 15.

Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan. Electronic address:

Objectives: Macrophage erythroblast attacher (MAEA) is a membrane protein that regulates the development of mature macrophages by mediating attachment with erythroblasts. A polymorphism rs6815464 (C/G) in MAEA gene was reported to be associated with type II diabetes. Along with diabetes, osteoporosis shows an increased prevalence in postmenopausal females, and both diseases have been reported to be associated with periodontitis. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.008DOI Listing

Glucosidase activity in dental biofilms in adolescent patients with fixed orthodontic appliances - a putative marker for white spot lesions - a clinical exploratory trial.

Arch Oral Biol 2019 Apr 8;102:122-127. Epub 2019 Apr 8.

Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö, Sweden.

Objectives: Approximately 25% of the adolescents in the Scandinavian population are treated with a fixed orthodontic appliance (FOA). Adverse effects such as enamel decalcification (white spot lesions - WSL), seem to affect over 30% of patients. WSL have only a limited ability to improve, thus seriously jeopardising the treatment outcome. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.003DOI Listing
April 2019
2 Reads

Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis.

Arch Oral Biol 2019 Apr 9;102:113-121. Epub 2019 Apr 9.

Department of Periodontology, School of Dentistry, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: The aim of this systematic review was to evaluate the existing evidence on the association between Thalassemia major (TM) and periodontal condition.

Materials & Methods: MEDLINE via OVID, EMBASE, and The Cochrane Database (including the Central Register of Controlled Trials (CENTER)), were searched up to September 2018 to identify observational studies eligible for systematic review and meta-analyses. Newcastle-Ottawa Scale (NOS) was used for quality assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183090
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http://dx.doi.org/10.1016/j.archoralbio.2019.04.004DOI Listing
April 2019
4 Reads

Developing biocompatible silver nanoparticles using epigallocatechin gallate for dental use.

Arch Oral Biol 2019 Mar 28;102:106-112. Epub 2019 Mar 28.

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. Electronic address:

Objective: To develop silver nanoparticles (AgNPs) using epigallocatechin gallate (EGCG) and evaluate its biocompatibility and inhibition effect on Streptococcus mutans biofilm growth.

Design: AgNPs were synthesized using EGCG as a reducing agent. Cytotoxicity was assessed using half-maximal inhibitory concentration (IC) against human gingival fibroblast (HGF-1) and stem cells from human exfoliated deciduous teeth (SHED). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.022DOI Listing

MicroRNA-23a inhibits osteogenesis of periodontal mesenchymal stem cells by targeting bone morphogenetic protein signaling.

Arch Oral Biol 2019 Apr 4;102:93-100. Epub 2019 Apr 4.

Department of Stomatology, Tianjin Union Medical Center, Tianjin 300121, China. Electronic address:

Objectives: To investigate the role of microRNA-23a (miR-23a) in the osteogenesis of periodontal mesenchymal stem cells (PDLSCs) in periodontitis.

Materials And Methods: Gingival crevicular fluid samples were collected from 21 control subjects and 29 patients with chronic periodontitis. MiR-23a was determined by quantitative real-time PCR. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.001DOI Listing

The pH-dependent effect of cationic and non-ionic delmopinol on planktonic and biofilm bacteria.

Authors:
Torgny Sjödin

Arch Oral Biol 2019 Apr 6;102:101-105. Epub 2019 Apr 6.

Department of Oral Biology, Faculty of Odontology, Malmö University, SE-205 06 Malmö, Sweden. Electronic address:

Objectives: The primary purpose was to evaluate the antimicrobial effects of cationic and non-ionic delmopinol on planktonic and biofilm bacteria.

Methods: Determination of the minimum inhibitory concentrations on planktonic and biofilm bacteria was performed below and above the pK-value of delmopinol. Test bacteria were Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.014DOI Listing
April 2019
3 Reads

Acetaminophen reduces apical root resorption during orthodontic tooth movement in rats.

Arch Oral Biol 2019 Apr 5;102:83-92. Epub 2019 Apr 5.

Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Objective: The present study aimed to investigate the inhibitory effect of acetaminophen on apical root resorption during orthodontic tooth movement by controlling inflammation in the periodontal ligament and apical pulp tissue.

Methods: Human periodontal ligament and pulp cells were subjected to 10 kPa of cyclic tensile force (CTF) in a Flexcell Strain Unit for 48 h. Then, 10 and 100 μM acetaminophen were added to the culture medium, and the expression of interleukin (IL)-1B, receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor (TNF)α, and colony stimulating factor 1 (CSF1) were evaluated. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.04.002DOI Listing
April 2019
3 Reads

Tea polyphenols: The application in oral microorganism infectious diseases control.

Arch Oral Biol 2019 Mar 30;102:74-82. Epub 2019 Mar 30.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

One of the most popular drinks worldwide, tea is rich in polyphenols and is beneficial to our health because it contributes to the prevention of many diseases. In the human oral cavity, there are more than 750 different species of bacteria living together within dental plaque. Some of the bacteria are pathogens that contribute to the development of oral diseases such as dental caries, periodontitis, pulpitis, mucosal disease, or halitosis through their virulence factors and their metabolites. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.027DOI Listing
March 2019
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Influence of adjuvant therapy with green tea extract in the treatment of experimental periodontitis.

Arch Oral Biol 2019 Apr 3;102:65-73. Epub 2019 Apr 3.

São Paulo State University (UNESP), School of Dentistry, Department of Basic Science - Histology Division, Araçatuba, SP, Brazil.

Aim: This study evaluated the effects of topical green tea extract solution (GTE) as adjuvant therapy to mechanical debridement for the treatment of experimental periodontitis (EP).

Material And Methods: We used 120 male rats (Rattus norvegicus albinus - Wistar), divided into the following four groups: NEP (sham) (n = 30): no experimental periodontitis (NEP), only simulation of EP by installation and removal of a ligature; EP (n = 30): EP induction by ligature; SRP (n = 30): EP, scaling and root planing (SRP), and irrigation with physiological saline solution; SRP/GT (n = 30): EP, SRP, and irrigation with GTE. Histologic analysis and immunohistochemistry were performed for detection of interleukin (IL)1ß, tumor necrosis factor-alpha (TNF-α), IL-10, and anti-tartrate resistant acid phosphatase (TRAP) in the furcation area. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.028DOI Listing
April 2019
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Autophagy in periodontal disease: Evidence from a literature review.

Arch Oral Biol 2019 Apr 1;102:55-64. Epub 2019 Apr 1.

Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, London, UK; Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Objective: To summarize evidence and data relating to the implications of autophagy in periodontal disease (PD) and to describe potential nutraceuticals or pharmaceuticals that could modulate this cell death subtype.

Design: Literature searches of various electronic databases (Medline via PubMed, SCOPUS, Web of Science, and EMBASE) using appropriate keywords (e.g. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.029DOI Listing

Characterization of titanium surface coated with epidermal growth factor and its effect on human gingival fibroblasts.

Arch Oral Biol 2019 Mar 29;102:48-54. Epub 2019 Mar 29.

Department of Physiology and Pathology, UNESP - Univ. Estadual Paulista, Araraquara School of Dentistry, Araraquara, Brazil. Electronic address:

Objectives: Different strategies, such as modifications on the implant abutments surface have been proposed to accelerate and improve the formation of the biological seal (BS). The aim of this study was to characterize a titanium (Ti) surface impregnated with epidermal growth factor (EGF) and to assess its influence on the metabolism and adhesion of oral mucosal cells.

Design: Ti discs were coated with EGF (100 nM) conjugated with a fluorophore and analyzed by fluorescence microscopy. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.025DOI Listing

Corrigendum to "Efficacy of different strategies to treat root dentin eroded by liquid or gaseous hydrochloric acid associated with brushing abrasion" [Arch. Oral Biol. Vol. 89 (2018), Pages 65-69].

Arch Oral Biol 2019 Apr 5;102:47. Epub 2019 Apr 5.

Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-904, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.019DOI Listing

Combination of estrogen deficiency and excessive mechanical stress aggravates temporomandibular joint osteoarthritis in vivo.

Arch Oral Biol 2019 Mar 18;102:39-46. Epub 2019 Mar 18.

Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. Electronic address:

Objective: It has been suggested that degenerative conditions of the temporomandibular joint (TMJ), such as osteoarthritis (OA) and progressive condylar resorption, are caused by multiple etiological factors, such as hormonal imbalance and excessive mechanical stress. However, it is unclear whether these factors interrelate in the degenerative process of the condyle. The aim of this study was to observe the effects of combined hormonal imbalance and excessive mechanical stress on the condyle using a mouse model. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.012DOI Listing
March 2019
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Small molecules enhance neurogenic differentiation of dental-derived adult stem cells.

Arch Oral Biol 2019 Mar 29;102:26-38. Epub 2019 Mar 29.

Endodontology, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong, China; HKU-Shenzhen Institute of Research and Innovation, Shenzhen, China. Electronic address:

Objective: Dental-derived stem cells originate from the embryonic neural crest, and exhibit high neurogenic potential. This study aimed to investigate whether a cocktail of eight small molecules (Valproic acid, CHIR99021, Repsox, Forskolin, SP600125, GO6983, Y-27632 and Dorsomorphin) can enhance the in vitro neurogenic differentiation of dental pulp stem cells (DPSCs), stem cells from apical papilla (SCAPs) and gingival mesenchymal stem cells (GMSCs), as a preliminary step towards clinical applications.

Materials And Methods: Neural induction was carried out with a small molecule cocktail based two-step culture protocol, over a total duration of 14 days. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.024DOI Listing

Experimental study of rhBMP-2 chitosan nano-sustained release carrier-loaded PLGA/nHA scaffolds to construct mandibular tissue-engineered bone.

Arch Oral Biol 2019 Mar 28;102:16-25. Epub 2019 Mar 28.

Department of Oral & Maxillofacial Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; School of Stomatology, Qingdao University, Qingdao, Shandong, China.

Objectives: To develop PLGA/nHA scaffold containing BMP-2 cell growth factor chitosan sustained release system as tissue engineered bone for repairing large jaw defects, test its sustained release rhBMP-2 efficiency in vitro, and evaluate its Osteogenesis in rabbit mandibular defects.

Methods: Tissue engineered bone scaffold complexes were prepared by complexing rhBMP-2 loaded chitosan (CS / rhBMP-2) nano sustained release carrier with PLGA / nHA scaffold carrier by 3D printing. In vitro, the porosity, pore size and degradation rate and the dose-time effect relationship of cytokine release were examined. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.023DOI Listing
March 2019
1.880 Impact Factor

Autophagy preserves the osteogenic ability of periodontal ligament stem cells under high glucose conditions in rats.

Arch Oral Biol 2019 May 26;101:172-179. Epub 2019 Mar 26.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, China. Electronic address:

Objective: To investigate how a high glucose environment influences the osteogenic ability of periodontal ligament stem cells (PDLSCs) and the function of autophagy in this process, we explored whether the osteogenic ability of PDLSCs could be protected by autophagy.

Design: PDLSC proliferation and osteogenesis were evaluated by CCK-8 and western blotting under gradient glucose conditions. The Autophagy RT Profiler PCR Array was used to screen autophagy-related mRNA expression during PDLSC osteoblastic differentiation on 5. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.020DOI Listing
May 2019
4 Reads

Evaluation of bone regeneration in a critical size cortical bone defect in rat mandible using microCT and histological analysis.

Arch Oral Biol 2019 May 5;101:165-171. Epub 2019 Feb 5.

Instituto de Física, Universidad Nacional Autónoma de México, 04510, México; Unidad de Investigación Biomédica en Cáncer INCan/UNAM, Instituto Nacional de Cancerología, 14280, México. Electronic address:

Goal: Evaluate bone regeneration in a critical size bone defect model in the jaw of healthy rats as a function of gender and defect location.

Design: A series of microCT and histological studies were performed to evaluate the process of bone regeneration in rats with a mandibular critical size defect. Rats were placed in two groups according to gender and sorted in terms of bone defect location. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.01.010DOI Listing

Role of autophagy induced by arecoline in angiogenesis of oral submucous fibrosis.

Arch Oral Biol 2019 Mar 28;102:7-15. Epub 2019 Mar 28.

Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objectives: To detect the expression of protein light chain 3 (LC3) and p62-SQSTM1 (p62) in the lamina propria of oral submucous fibrosis (OSF) and to determine the association of autophagy with OSF. To investigate the role of autophagy in angiogenesis of human umbilical vein endothelial cells (HUVECs) and to assess whether this effect was induced by arecoline.

Methods: LC3 and p62 expression was detected in OSF tissue through immunohistochemistry (IHC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969193006
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http://dx.doi.org/10.1016/j.archoralbio.2019.03.021DOI Listing
March 2019
9 Reads

Effect of polyphenol-rich cranberry extracts on cariogenic biofilm properties and microbial composition of polymicrobial biofilms.

Arch Oral Biol 2019 Mar 30;102:1-6. Epub 2019 Mar 30.

The University of Queensland School of Dentistry, Brisbane, Australia.

Objective: To investigate the effect of cranberry extracts on saliva-derived polymicrobial biofilms with regards to biofilm biomass, acidogenicity, exopolysaccharide (EPS)/microbial biovolumes, colony forming unit (CFU) counts, and the relative abundance of specific caries- and health-associated bacteria.

Methods: Saliva-derived polymicrobial biofilms were grown for 96 h in a cariogenic environment and treated for 2 min every 12 h over the entire biofilm growth period with 500 μg/mL cranberry extract or vehicle control. The effect of the cranberry extract on biofilm behaviour was evaluated using different assays and its influence on key cariogenic and health-associated bacterial populations was assessed with a microarray real-time quantitative PCR method. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.026DOI Listing
March 2019
1 Read

Interleukin gene polymorphisms in chronic periodontitis: A case-control study in the Indian population.

Arch Oral Biol 2019 May 26;101:156-164. Epub 2019 Mar 26.

Department of Biotechnology, Centre for Genetic studies, School of Biotechnology and Biological Sciences, Maulana Abul Kalam Azad University of Technology, West Bengal, India.

Objective: The aim of the present study was to investigate the possible association between seven Interleukin (IL) gene polymorphisms and their interaction with the chronic inflammatory oral disease, chronic periodontitis in Indian population.

Design: A total of 357 study subjects (157 with chronic periodontitis and 200 with healthy control) were genotyped for IL1A -889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944), IL1B + 3954C/T (rs1143634), IL2 -330 T/G (rs2069762), IL4 -33C/T (rs2070874), IL6 -597 G/A (rs1800797), IL8 -251A/T (rs4073), IL10 -819C/T (rs1800871), IL10 -592A/C (rs1800872) and IL13 -1111C/T (rs1800925). Statistical analysis was performed using the statistical software package SPSS v16. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.015DOI Listing

Enamel pearls: Their occurrence in recent human populations and earliest manifestation in the modern human lineage.

Arch Oral Biol 2019 May 16;101:147-155. Epub 2019 Mar 16.

CT Scanner Unit, Central Analytical Facilities of Stellenbosch University, Stellenbosch, 7602, South Africa.

Objective: To document and describe the occurrence of an enamel pearl on the distal root surface of the maxillary M3 of the fossil hominin specimen from Florisbad, South Africa that is dated to ca. 259,000 years B.P. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.004DOI Listing
May 2019
2 Reads

Candida species in intact in vivo biofilm from carious lesions.

Authors:
I Dige B Nyvad

Arch Oral Biol 2019 May 25;101:142-146. Epub 2019 Mar 25.

Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark.

Objectives: The aim of this study was to investigate the occurrence and spatial localization of Candida species in intact in vivo biofilm from caries lesions in root and occlusal surfaces.

Materials And Methods: Biofilm from 7 teeth with root caries and 9 teeth with occlusal caries were analyzed. The teeth were fixed, embedded, sectioned and decalcified before fluorescence in situ hybridization using oligonucleotide probes against all bacteria (EUB338), all yeast (PF2), streptococci (STR405, MUT590) and C. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.017DOI Listing
May 2019
1 Read

Phosphoryl oligosaccharides of calcium enhance mineral availability and fluorapatite formation.

Arch Oral Biol 2019 May 25;101:135-141. Epub 2019 Mar 25.

Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Japan. Electronic address:

Objectives: Phosphoryl oligosaccharides of calcium (POs-Ca) are a highly soluble calcium source and can keep the solubility of calcium and fluoride ions. The aim of this study was to investigate the effect of calcium (from POs-Ca) and fluoride ions penetrate into subsurface enamel lesions in vitro.

Design: Demineralized bovine enamel slabs were remineralizedin vitro for 24 h at 37 °C with artificial saliva (AS) containing POs-Ca and various fluoride concentrations (0-100 ppm), or AS containing different levels of POs-Ca adjusted to a Ca/P ratio of 0. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.018DOI Listing

Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis.

Arch Oral Biol 2019 May 25;101:130-134. Epub 2019 Mar 25.

Department of Gerodontology and Oral Pathology, University of Medical Sciences, Poznan, Poland.

Objective: The purpose of this study was to evaluate the possible association between two single nucleotide polymorphisms of the β-defensin 1 gene: -20 G > A and -44 C > G at 5 untranslated region and recurrent aphthous stomatitis in a cohort of Polish patients.

Design: One hundred and six patients suffering from recurrent aphthous stomatitis and 96 healthy volunteers were genotyped at β-defensin 1-20 G > A and -44 C > G using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The results were statistically analysed with the difference test between two proportion and chi-square tests with p < 0. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.016DOI Listing
May 2019
1 Read

FimH as a mucosal adjuvant enhances persistent antibody response and protective efficacy of the anti-caries vaccine.

Arch Oral Biol 2019 May 18;101:122-129. Epub 2019 Feb 18.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan 430079,China. Electronic address:

Objective: To investigate whether the recombinant FimH-S.T protein could modulate immune response to anti-caries vaccine in vitro and in vivo.

Design: Recombinant FimH protein derived from Salmonella was constructed and purified. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.009DOI Listing

Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide.

Arch Oral Biol 2019 May 14;101:108-121. Epub 2019 Mar 14.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, 145 Changle West Road, Xi'an, China. Electronic address:

Objective: Chondrocyte apoptosis is a pathological manifestation of osteoarthritis. The goal of this report was to explore the role of nitric oxide in chondrocyte apoptosis in osteoarthritic mandibular condylar cartilage.

Design: This study used our reported experimental unilateral anterior crossbite in vivo rat model and chondrocyte fluid flow shear stress in vitro model. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.006DOI Listing
May 2019
1 Read
1.880 Impact Factor

A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.

Arch Oral Biol 2019 May 18;101:100-107. Epub 2019 Mar 18.

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China. Electronic address:

Objective: To explore the gene mutation in an incontinentia pigmenti (IP) patient with syndromic tooth agenesis.

Methods: Long-range polymerase chain reaction (PCR) and Sanger sequencing were used to detect inhibitor of nuclear factor kappa-B kinase subunit gamma (IKBKG) mutation in the IP patient. We used the nuclear factor kappa B (NF-κB) reporter gene to assess activation of NF-κB, after transfecting an empty vector, wild-type, or mutant NF-κB essential modulator (NEMO) plasmid into IKBKG-deficient HEK293T cells, respectively. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.013DOI Listing
May 2019
7 Reads

Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls.

Arch Oral Biol 2019 May 4;101:92-99. Epub 2019 Mar 4.

Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address:

Objective: The aim of the study was to profile the subgingival microbiome of Chinese adults with generalized aggressive periodontitis (GAgP) using human oral microbe identification microarray (HOMIM), and to compare the results with matched periodontal healthy controls.

Design: 15 subjects with GAgP and 15 age- and gender- matched periodontal healthy controls were included. Subgingival plaque samples were collected from the deepest pockets of patients with GAgP and matched sites in controls and then analyzed by 16S rRNA-based microarrays. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.012DOI Listing

Integrin-α5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway.

Arch Oral Biol 2019 May 11;101:85-91. Epub 2019 Mar 11.

Oral and Maxillofacial Surgery, Liaocheng People's Hospital, Liaocheng, China. Electronic address:

Background: Integrin-α5 (ITGA5) gene has been reported to be critical for the progression of several cancers. However, the effects of ITGA5 in oral squamous cell carcinoma (OSCC) remain unclear.

Methods: We firstly used bioinformatics methods to analyze the ITGA5 gene expression based on the public dataset. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.007DOI Listing
May 2019
1 Read

Sub-antimicrobial doses of doxycycline decreased bone loss related to ligature-induced periodontitis in hypertensive rats.

Arch Oral Biol 2019 May 19;101:77-84. Epub 2019 Mar 19.

Department of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Background/objective: The beneficial effects of sub-antimicrobial dose doxycycline (SDD) associated with nonsurgical periodontal therapy are well documented. Recently, the effects of SDD on metalloproteinases have been investigated in the treatment of hypertension. The aim of this study was to evaluate the effects of SDD on ligature-induced periodontitis in spontaneously hypertensive rats (SHR). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.011DOI Listing

Effects of mechanical force application on the developing root apex in rat maxillary molars.

Arch Oral Biol 2019 May 15;101:64-76. Epub 2019 Mar 15.

Department of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Objectives: We aimed to investigate the effects of mechanical force application on the developing root apex in vivo.

Design: Mechanical force was applied on the maxillary first molars of Sprague-Dawley rats at postnatal day 21 for 1, 3, 5, and 7 days to induce tooth movement. We observed the developing root apex of the mesial root of first molar by using micro-focus X-ray computed tomography, histological staining, immunohistochemistry and in situ hybridization to analyze apical cell proliferation and gene expression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183085
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http://dx.doi.org/10.1016/j.archoralbio.2019.03.010DOI Listing
May 2019
11 Reads

Serum microRNAs and chronic periodontitis: A case-control study.

Arch Oral Biol 2019 May 13;101:57-63. Epub 2019 Mar 13.

Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Objective: An association is present between periodontitis and rates of expression of certain microRNAs (miRNAs) in periodontal tissue. However, the association between periodontitis and miRNA levels in human serum is unknown. We performed a case-control study in patients with chronic periodontitis to investigate serum miRNA levels. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.009DOI Listing

Role of oral flora in chemotherapy-induced oral mucositis in vivo.

Arch Oral Biol 2019 May 14;101:51-56. Epub 2019 Mar 14.

Faculty of Dentistry, National University of Singapore, Singapore. Electronic address:

Objective: To determine if commensal oral microflora impacts the severity of chemotherapy-induced oral mucositis (OM).

Design: Specific-pathogen-free (SPF) and germ-free Swiss Webster mice in the experimental groups were dosed with 5-fluorouracil (5-FU) to induce OM. Mice in the control group received phosphate buffered saline. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.008DOI Listing
May 2019
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Ift88 limits bone formation in maxillary process through suppressing apoptosis.

Arch Oral Biol 2019 May 27;101:43-50. Epub 2019 Feb 27.

Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, UK. Electronic address:

Objective: The development of the maxillary bone is under strict molecular control because of its complicated structure. Primary cilia play a critical role in craniofacial development, since defects in primary cilia are known to cause congenital craniofacial dysmorphologies as a wide spectrum of human diseases: the ciliopathies. The primary cilia also are known to regulate bone formation. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.017DOI Listing
May 2019
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Compensatory dentoalveolar supraeruption and occlusal plane cant after botulinum-induced hypotrophy of masticatory closing muscles in juvenile rats.

Arch Oral Biol 2019 May 5;101:34-42. Epub 2019 Mar 5.

Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea; Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, South Korea. Electronic address:

Objective: The purpose of this study was to investigate changes in the dentoalveolus and occlusal plane associated with the hypotrophy of unilateral masticatory muscles following botulinum toxin (BTX) treatment in the juvenile period of rats.

Design: We hypothesized that the loss of functional loading of masticatory muscles and occlusal force invites compensatory dentoalveolar supraeruption, accelerating occlusal cant and skeletal asymmetry. In order to confirm this hypothesis, six-week-old male rats (N = 5) were treated with BTX simultaneously at the unilateral masseter, temporalis, and medial pterygoid muscles, with a booster injection after six weeks for the experimental group. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.003DOI Listing

Effect of jaw functional status on neck muscle endurance.

Arch Oral Biol 2019 May 4;101:30-33. Epub 2019 Mar 4.

Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Objective: To investigate the effect of resting jaw and maximum voluntary clenching on neck flexor and extensor muscle endurance.

Design: Neck flexor and extensor endurance was measured in a college health clinic in 85 male college students in two test positions: resting jaw (control) and maximum voluntary clenching.

Results: Mean neck flexor muscle endurance values during resting jaw and maximum voluntary clenching were 70. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.001DOI Listing
May 2019
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Physiological concentrations of denosumab enhance osteogenic differentiation in human mesenchymal stem cells of the jaw bone.

Arch Oral Biol 2019 May 7;101:23-29. Epub 2019 Mar 7.

Department of Cranio-Maxillofacial Surgery, Hospital of the University of Regensburg, Franz-Josef-Strauß-Allee, 93053 Regensburg, Germany. Electronic address:

Objective: The aim of this study was to evaluate the possible influence of denosumab and zoledronate on proliferation and osteogenic differentiation of alveolar bone stem cells.

Design: Mesenchymal stem cells (MSCs) and dental follicle cells (DFCs) were grown under osteogenic differentiation with concentrations from 0.25 μM to 10 μM (zoledronate) and to 20 μM (denosumab). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.005DOI Listing
May 2019
2 Reads

Galleria mellonella as an experimental model to study human oral pathogens.

Arch Oral Biol 2019 May 5;101:13-22. Epub 2019 Mar 5.

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, São Paulo, Brazil. Electronic address:

The oral cavity is home to a microbial community of more than 800 species. This important microbiome is formed by commensal and opportunistic bacteria, fungi and viruses. Several distinct habitats within the mouth support heterogeneous microbial communities that constitute an important link between oral and general health. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.002DOI Listing

Combination of 5-Florouracil and polyphenol EGCG exerts suppressive effects on oral cancer cells exposed to radiation.

Arch Oral Biol 2019 May 28;101:8-12. Epub 2019 Feb 28.

Department of Oral Medicine, University of Murcia, Murcia, Spain.

Objective: Natural compounds such as epigallocatechin-3-gallate (EGCG) have previously shown chemotherapeutic properties with few side-effects. In our study, we evaluated the effects of combining EGCG with 5-fluorouracil (5-FU) and radiotherapy on oral squamous cell cancer. We evaluated whether the combination of lower doses of 5-FU with EGCG could be equally or more effective than the use of higher doses of 5-FU alone. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.018DOI Listing
May 2019
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Bite force measurements for objective evaluations of orthodontic tooth movement-induced pain in rats.

Arch Oral Biol 2019 May 4;101:1-7. Epub 2019 Feb 4.

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objective: To examine the reliability of bite force for evaluating orthodontic tooth movement-induced pain in rats.

Design: Orthodontic tooth movement-induced pain was induced by mounting springs (40 g) between incisors and ipsilateral molars in male Sprague-Dawley rats. Five group sets of animals were used: for the first group set, 20 rats were randomly divided into a force group (n = 10) and a sham group (n = 10); for the second group set, 20 rats were divided into a 20-g group and a 80-g group; for the third group set, 20 rats were randomly divided into either a CFA group (complete freund's adjuvant) (n = 10) receiving periodontal injections of CFA at baseline or a control group (n = 10) receiving periodontal injections of saline at baseline; for the forth group set, 24 rats were randomly divided into the following four groups: force + saline, control + saline, force + antiNGF and control + NGF (NGF: nerve growth factor). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.002DOI Listing
May 2019
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Marine bromophenols as an effective inhibitor of virulent proteins (peptidyl arginine deiminase, gingipain R and hemagglutinin A) in Porphyromas gingivalis.

Arch Oral Biol 2019 Apr 23;100:119-128. Epub 2019 Feb 23.

Karunya Institute of Technology & Sciences, India.

Objectives: Porphyromonas gingivalis, is one of the major oral pathogen that produce virulent proteins which mediate periodontal tissue inflammation and infection. Marine algae have recently gained popularity for its bioactive molecules and their oral applications. Marine bromophenols (MBs) is abundant in red algae which are reported to have wide medicinal properties. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.016DOI Listing
April 2019
2 Reads

Efficacy of β-caryophyllene for periodontal disease related factors.

Arch Oral Biol 2019 Apr 21;100:113-118. Epub 2019 Feb 21.

Department of Dental Hygiene, Ulsan College, 101 Bongsu-ro, Dong-gu, 44022, Ulsan, South Korea. Electronic address:

Objective: This study aimed to investigate the antimicrobial activity of β-caryophyllene against periodontopathogens as well as its inhibitory effects on the expression of inflammatory cytokines and production of volatile sulfur compounds by lipopolysaccharide and periodontopathogenic enzymes, respectively.

Design: The antimicrobial activity of β-caryophyllene againstPorphyromonas gingivalis, Tannerella forsythia, and Treponema denticola was investigated via a susceptibility assay using a microplate reader. THP-1 cells were treated with lipopolysaccharide in the presence or the absence of β-caryophyllene, and the expression and production of inflammatory cytokines were then analyzed by a real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.015DOI Listing

Notch pathway deactivation mediated by F-box/WD repeat domain-containing 7 ameliorates hydrogen peroxide-induced apoptosis in rat periodontal ligament stem cells.

Arch Oral Biol 2019 Apr 19;100:93-99. Epub 2019 Feb 19.

Department of Stomatology, Punan Hospital of Pudong New District, Shanghai, China. Electronic address:

Objective: To investigate the protective role of F-box/WD repeat domain-containing 7 in rat periodontal ligament stem cells under oxidative stress.

Materials And Methods: The apoptosis of rat periodontal ligament stem cells was induced by exposure to various concentrations of hydrogen peroxide for 24 h, after which cell viability and the cleaved caspase-3 and -9 levels were determined. The levels of proteins in the Notch signaling pathway were determined by western blotting. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.010DOI Listing

Cross-kingdom interaction of Candida albicans and Actinomyces viscosus elevated cariogenic virulence.

Arch Oral Biol 2019 Apr 18;100:106-112. Epub 2019 Feb 18.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address:

Objective: How the interactions between Candida albicans and Actinomyces viscosus contributed to the root caries was not clear. This study aimed to investigate their cross-kingdom interactions on the biomass and the cariogenic virulence in dual-species biofilms.

Design: Suspensions of C. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.008DOI Listing
April 2019
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1.880 Impact Factor

Effects of two fast-setting pulp-capping materials on cell viability and osteogenic differentiation in human dental pulp stem cells: An in vitro study.

Arch Oral Biol 2019 Apr 20;100:100-105. Epub 2019 Feb 20.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China School and Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. Electronic address:

Objective: The purpose of this study was to compare the effects of two fast-setting pulp-capping materials, Biodentine (BD) and iRoot Fast Set (FS) root repair material, on the attachment, viability, migration, and differentiation of human dental pulp stem cells (hDPSCs).

Methods: A comparative study was conducted between BD and FS material disks. Scanning electron microscope (SEM) images were used to observe the attachment of hDPSCs on the disks. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.014DOI Listing
April 2019
1.880 Impact Factor

Fusobacterium nucleatum stimulates monocyte adhesion to and transmigration through endothelial cells.

Arch Oral Biol 2019 Apr 20;100:86-92. Epub 2019 Feb 20.

Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objective: Fusobacterium nucleatum (F. nucleatum) is an important pathogen in periodontitis. Previous studies have demonstrated its ability to spread via haematogenesis and modulate host immune responses. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.013DOI Listing
April 2019
2 Reads

Changes in the expression of the potassium channels TASK1, TASK3 and TRESK in a rat model of oral squamous cell carcinoma and their relation to malignancy.

Arch Oral Biol 2019 Apr 16;100:75-85. Epub 2019 Feb 16.

Instituto de Histología y Embriología de Mendoza "Dr. M. Burgos" (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.

Objectives: Potassium channels have been proposed to promote cancer cell proliferation and metastases. Thus, we investigated the expression pattern of three 2-pore domain potassium channels (K2Ps) TASK1, TASK3 and TRESK in advanced oral squamous cell carcinoma (OSCC), the commonest oral malignancy.

Design: We used 4-nitroquinoline-1-oxide (4-NQO) to induce high grade OSCC in male adult rats. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.007DOI Listing
April 2019
2 Reads

Ontogenetic development of the oral apparatus and oropharyngeal cavity in bullfrog tadpoles (Lithobates catesbeianus, Shaw 1802).

Arch Oral Biol 2019 Apr 20;100:69-74. Epub 2019 Feb 20.

Brazil University (Univ. Brasil), Campus Fernandópolis - Est. Projetada F-1, s/n - Fazenda Santa Rita, 15600-000, Fernandópolis, SP, Brazil. Electronic address:

Objective: The present study aimed to describe the morphology of oral apparatus and oral cavity of bullfrog tadpoles during their development and metamorphosis.

Design: The oral apparatus and oropharyngeal cavity of tadpoles from hatching up to metamorphosis stage was dissected for further analysis. These structures were fixed in Karnovsky solution, afterwards in osmium tetroxide and metalized in palladium gold and electron-micrographed using the scanning electron microscope. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.011DOI Listing
April 2019
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Adsorption and release kinetics of growth factors on barrier membranes for guided tissue/bone regeneration: A systematic review.

Arch Oral Biol 2019 Apr 16;100:57-68. Epub 2019 Feb 16.

Department of Craniomaxillofacial Surgery, University of Bern, Bern, Switzerland. Electronic address:

Objectives: Guided bone / tissue regeneration (GBR/GTR) procedures are necessary to improve conditions for implant placement. These techniques in turn can be enhanced by using growth factors (GFs) such as bone morphogenetic protein (BMP-2) and platelet-derived growth factor (PDGF) to accelerate regeneration. The aim of the present systematic review was to evaluate the GF loading and release kinetics of barrier membranes. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.006DOI Listing
April 2019
1 Read