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    The PBII gene of the human salivary proline-rich protein P-B produces another protein, Q504X8, with an opiorphin homolog, QRGPR.
    Arch Oral Biol 2018 Jan 10;88:10-18. Epub 2018 Jan 10.
    Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan.
    Objectives: The NCBI gene database and human-transcriptome database for alternative splicing were used to determine the expression of mRNAs for P-B (SMR3B) and variant form of P-B. The translational product from the former mRNA was identified as the protein named P-B, whereas that from the latter has not yet been elucidated. In the present study, we investigated the expression of P-B and its variant form at the protein level. Read More

    Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats.
    Arch Oral Biol 2018 Jan 9;88:1-9. Epub 2018 Jan 9.
    Department of Surgery and Bucco-Maxillofacial Traumatology and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address:
    Objective: The purpose of this study was to evaluate whether local administration of TIL could influence the expression of the inflammatory mediators IL-1β, TNF-α, MMP-8 and COX-2 in rats with experimental periodontitis (EP).

    Methods: Twenty-four adult male rats (Rattus norvegicus, albinus, Wistar) were assigned to groups C, EP, EP-TIL (CControl group, EP-Periodontitis groups). On EP groups, a ligature was placed around maxillary 2nd molars on day 1. Read More

    Maresin 1 regulates autophagy and inflammation in human periodontal ligament cells through glycogen synthase kinase-3β/β-catenin pathway under inflammatory conditions.
    Arch Oral Biol 2017 Dec 23;87:242-247. Epub 2017 Dec 23.
    Department of Stomatology, Traditional Chinese Medicine Hospital, Yan'an, 716000, China. Electronic address:
    Objective: Accumulating lines of evidence suggest that maresin 1 (MaR-1) exerts anti-inflammatory effects in many cell types and plays beneficial roles in inflammatory disease, such as peritonitis and colitis. Moreover, it has been demonstrated that MaR-1 play protective roles against localized aggressive periodontitis. However, the function and mechanism of MaR-1 in human periodontal ligament cells (PDL) cells from periodontitis are poorly understood. Read More

    Effects of sub-minimum inhibitory concentrations of lemon essential oil on the acid tolerance and biofilm formation of Streptococcus mutans.
    Arch Oral Biol 2017 Dec 29;87:235-241. Epub 2017 Dec 29.
    Department of Preventive Dentistry & Pediatric Dentistry, School of Stomatology, Tianjin Medical University, No. 22, Qixiangtai Road, Tianjin 300070, China. Electronic address:
    Objectives: Lemon essential oil (LEO) is a kind of secondary metabolite from lemon peels and has been found to inhibit cariogenic bacteria for decades. However, its effects on main cariogenic virulence factors are rarely reported. The present study aimed to investigate the effects of sub-minimum inhibitory concentrations (sub-MICs) of LEO on the acid tolerance and biofilm formation of Streptococcus mutans (S. Read More

    Ultrastructural damage in Streptococcus mutans incubated with saliva and histatin 5.
    Arch Oral Biol 2018 Jan 8;87:226-234. Epub 2018 Jan 8.
    Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Av. Universidad 3000, Col. Universidad Nacional Autónoma de México, CP 04510, México City, Mexico.
    Objective: To study the ultrastructural alterations induced in Streptococcus mutans (ATCC 25175) incubated with saliva, saliva plus histatin 5 and histatin 5.

    Methods: S. mutans incubated with saliva histatin 5 or a combination of both were morphologically analyzed and counted. Read More

    Topical chlorhexidine, povidone-iodine and erythromycin in the repair of traumatic ulcers on the rat tongue: Clinical, histological and microbiological evaluation.
    Arch Oral Biol 2018 Jan 4;87:218-225. Epub 2018 Jan 4.
    Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, RS, Brazil.
    Objective: This study investigated the effect of topical application of 0.12% chlorhexidine, 10% povidone-iodine and 50% erythromycin on the optimization of healing process of traumatic ulcers made on ventral tongue of rats.

    Design: Forty-Eight Wistar rats were randomly divided into four groups: control, chlorhexidine (Chx), povidone-iodine (PvI) and erythromycin (Er). Read More

    Epigenetic mechanisms in odontogenic tumors: A literature review.
    Arch Oral Biol 2017 Dec 30;87:211-217. Epub 2017 Dec 30.
    Universidad Autónoma de Baja California, Mexicali, BC, Mexico. Electronic address:
    Objective: Epigenetic mechanisms, such as DNA methylation, regulate important biological processes as gene expression and it was suggested that these phenomena play important roles in the carcinogenesis and tumor biology. The aim of this review is to provide the current state of knowledge about epigenetic alterations, focusing mainly on DNA methylation, reported in odontogenic tumors.

    Design: Literatures were searched based in the combination of the following keywords: odontogenic tumors, epigenetics, DNA methylation, histone modifications, non-coding RNA, microRNA, DNA methyltransferases. Read More

    Influence on proliferation and adhesion of human gingival fibroblasts from different titanium surface decontamination treatments: An in vitro study.
    Arch Oral Biol 2017 Dec 24;87:204-210. Epub 2017 Dec 24.
    Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Electronic address:
    Objectives: To investigate the effects of different decontamination treatments on microstructure of titanium (Ti) surface as well as proliferation and adhesion of human gingival fibroblasts (HGFs).

    Material And Methods: Ti discs with machined (M) and sand blasted, acid etched (SAE) surfaces were treated with five different decontamination treatments: (1) stainless steel curette (SSC), ultrasonic system with (2) straight carbon fiber tip (UCF) or (3) metal tip (UM), (4) rotating Ti brush (RTB), and (5) Er:YAG laser (30 mJ/pulse at 30 Hz). Surface roughness was analyzed under optical interferometry. Read More

    The alveolar bone protective effects of natural products: A systematic review.
    Arch Oral Biol 2017 Dec 27;87:196-203. Epub 2017 Dec 27.
    Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil. Electronic address:
    Objectives: This systematic review was carried out to identify which naturally-occurring agents and constituents isolated therefrom have effects in preventing bone loss in a ligature-induced periodontitis model.

    Materials And Methods: Eight databases were systematically searched for studies of experimental periodontitis. The data were extracted, analyzed, and the treatment outcomes were given scores based on the level of bone destruction as compared to their untreated induced-periodontitis control. Read More

    Histological and chemical analyses of mesiodens development and mineralization.
    Arch Oral Biol 2017 Dec 23;87:191-195. Epub 2017 Dec 23.
    Barzilai Medical University Center, Ashkelon, 7830604, Israel. Electronic address:
    Objective: This study aimed to compare the developmental timing and mineralization quality of mesiodentes, i.e., supernumerary teeth located mainly in the midline of the maxilla between the central incisors, with the developmental timing and mineralization quality of permanent and primary central incisors. Read More

    Association between developmental defects of enamel and celiac disease: A meta-analysis.
    Arch Oral Biol 2017 Dec 28;87:180-190. Epub 2017 Dec 28.
    Department of Oral and Maxillofacial Surgery, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil. Electronic address:
    Objectives: Studies have observed the presence of extra-intestinal manifestations of celiac disease (CD), including involvement of the oral cavity, such that developmental defects of enamel (DDE) occur. Thus, the aim of this review was to access the polled prevalence of DDE in individuals with CD, and to establish the strength of the association between these two variables.

    Methods: To carry out the systematic review, four electronic databases and the Grey Literature were searched, complemented by a manual search of reference lists within the selected articles. Read More

    miR-143 suppresses the osteogenic differentiation of dental pulp stem cells by inactivation of NF-κB signaling pathway via targeting TNF-α.
    Arch Oral Biol 2017 Dec 30;87:172-179. Epub 2017 Dec 30.
    Department of Periodontology, The First Affiliated Hospital & School of Stomatology, Zhengzhou University, Zhengzhou, 450052, China.
    Background: Dental pulp stem cells (DPSCs) are multipotent and play an important role in repairing damaged and/or defective dentinogenesis/osteogenesis. Recent studies have documented the implication of miR-143 in osteogenic differentiation of DPSCs. Nevertheless, the detailed mechanisms of miR-143 involved in the osteogenic differentiation of DPSCs remain to be further elaborated. Read More

    Association of weight and height with timing of deciduous tooth emergence.
    Arch Oral Biol 2017 Dec 29;87:168-171. Epub 2017 Dec 29.
    Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Ramtha, Irbid, 22110, Jordan. Electronic address:
    Objectives: The aim of this study was to associate weight and height with the timing of deciduous tooth emergence.

    Methods: 1756 children, aged from 1 to 33 months (755 females and 1001 males) had been previously examined for the timing of deciduous tooth emergence and their weights and heights measured. Children were categorized into weight and height groups (underweight, normal, overweight, short stature, normal and tall stature). Read More

    Pulpal blood flow recorded from exposed dentine with a laser Doppler flow meter using red or infrared light.
    Arch Oral Biol 2017 Dec 16;87:163-167. Epub 2017 Dec 16.
    School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
    Objective: To determine the percentage of the blood flow signal that is derived from dental pulp when recording from exposed dentine in a human premolar.

    Design: Recordings were made from 7 healthy teeth in 5 subjects (aged 22-33 yr.) with a laser Doppler flow meter (Periflux 4001) using either a red (635 nm) or an infrared (780 nm) laser. Read More

    Bleaching and enamel surface interactions resulting from the use of highly-concentrated bleaching gels.
    Arch Oral Biol 2017 Dec 28;87:157-162. Epub 2017 Dec 28.
    Department of Dentistry, Health Science Institute, Federal University of Juiz de Fora (UFJF), Rua Israel Pinheiro, 2000, Bloco D9, Governador Valadares, MG, 35020-220, Brazil. Electronic address:
    Tooth bleaching is considered a non-invasive treatment, although the use of highly-concentrated products may provoke increased surface roughness and enamel demineralization, as well as postoperative sensitivity. Thus, the aim of this study was to investigate whether hydrogen peroxide (H2O2) concentration would affect tooth bleaching effectiveness and the enamel surface properties. Enamel/dentin bovine specimens (6 × 4 mm) were immersed in coffee solution for 7 days and evaluated with a spectrophotometer (Easyshade; baseline), using the CIEL*a*b* color parameters. Read More

    Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions.
    Arch Oral Biol 2017 Dec 21;87:151-156. Epub 2017 Dec 21.
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17120-901, Brazil. Electronic address:
    Objective: The present study was designed to analyze the immunolocalization of proteins involved in cytoskeleton remodeling, such as moesin and Rho-A, in benign odontogenic lesions that present with expansive growth and invasive clinical behavior.

    Materials And Methods: Expressions of moesin and Rho-A in odontogenic epithelium were evaluated by immunohistochemical analysis in 45 odontogenic lesions using monoclonal antibodies.

    Results: Our results demonstrated strong membranous and cytoplasmic expressions of moesin in the epithelial cells in 66. Read More

    Superhydrophilic co-polymer coatings on denture surfaces reduce Candida albicans adhesion-An in vitro study.
    Arch Oral Biol 2017 Dec 27;87:143-150. Epub 2017 Dec 27.
    Department of Removable Partial Prosthodontics, Graduate School, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. Electronic address:
    Objective: In this study, we aimed to investigate denture-base-resin coatings prepared with a crosslinkable co-polymer containing sulfobetaine methacrylamide (SBMAm) and the relationship between their surface characteristics and the initial adhesion of Candida albicans (C. albicans).

    Methods: Acrylic resin discs were coated with co-polymers containing various concentrations of SBMAm and N,N'-(4,7,10-trioxa-1,13-tridecadiamine) diacrylamide (JDA) as crosslinking agent. Read More

    Overexpression of sprouty2 in human oral squamous cell carcinogenesis.
    Arch Oral Biol 2017 Dec 27;87:131-142. Epub 2017 Dec 27.
    School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Oral Pathology & Maxillofacial Radiology, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:
    Objective: This study investigated SPRY2 expression in human oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs).

    Methods: 75 OSCCs, 23 OPMDs with malignant transformation (MT), 17 OPMDs without MT, and eight normal oral mucosa (NOM) tissues were used for immunohistochemical staining; three OSCC tissues with normal tissue counterparts were used for western blotting. Three human oral cancer cell lines (OCCLs), an oral precancer cell line (DOK), and a NOM primary culture (NOMPC) were used for western blotting; OCCLs and NOMPC were employed for real-time quantitative reverse transcription-polymerase chain reaction. Read More

    MyD88-mediated innate sensing by oral epithelial cells controls periodontal inflammation.
    Arch Oral Biol 2017 Dec 16;87:125-130. Epub 2017 Dec 16.
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, United States. Electronic address:
    Periodontal diseases are a class of non-resolving inflammatory diseases, initiated by a pathogenic subgingival biofilm, in a susceptible host, which if left untreated can result in soft and hard tissue destruction. Oral epithelial cells are the first line of defense against microbial infection within the oral cavity, whereby they can sense the environment through innate immune receptors including toll-like receptors (TLRs). Therefore, oral epithelial cells directly and indirectly contribute to mucosal homeostasis and inflammation, and disruption of this homeostasis or over-activation of innate immunity can result in initiation and/or exacerbation of localized inflammation as observed in periodontal diseases. Read More

    Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence.
    Arch Oral Biol 2017 Dec 23;87:115-124. Epub 2017 Dec 23.
    Periodontology and Oral Medicine, Faculty of Dentistry, Cairo University, Egypt. Electronic address:
    Objectives: The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva.

    Methods: A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017. Read More

    Prediction of agenesis of the mandibular second premolar using the developmental stages of the mandibular canine, first premolar, and second molar.
    Arch Oral Biol 2017 Dec 20;87:110-114. Epub 2017 Dec 20.
    Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, Seoul National University, Seoul National University Dental Hospital, 101, Daehakno, Jongno-gu, Seoul, Korea. Electronic address:
    Objective: The aim in this study was to suggest a standard for early diagnosis of agenesis of the mandibular second premolars (L5) by estimating the developmental stages of the mandibular canines (L3), first premolars (L4), and second molars (L7).

    Design: Among all 5136 pediatric patients aged 5-11 years who received panoramic radiographs between June 2008 and December 2009 at Seoul National University Dental Hospital, 215 control patients and 74 agenesis patients who met inclusion criteria were analyzed. The developmental stages of all L3, L4, L5, and L7 of control and agenesis patients were estimated using the method proposed by Demirjian. Read More

    Three-dimensional growth pattern of the rat mandible revealed by periodic live micro-computed tomography.
    Arch Oral Biol 2017 Dec 16;87:94-101. Epub 2017 Dec 16.
    Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, Republic of Korea; Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Electronic address:
    Objective: We wanted to evaluate the three-dimensional (3D) mandibular growth of Sprague-Dawley rats from 4th to 16th postnatal weeks with periodic and live micro-computed tomographic scanning.

    Design: Twenty Sprague-Dawley rats were used for micro-CT scanning from 4th to 16th postnatal weeks. After 3D reconstruction of rat mandible, we performed the linear and angular measurements and the superimposition of the 3D models to evaluate the mandibular growth of rat. Read More

    Mechanical stiffness of TMJ condylar cartilage increases after artificial aging by ribose.
    Arch Oral Biol 2017 Dec 16;87:102-109. Epub 2017 Dec 16.
    Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands. Electronic address:
    Objective: Aging is accompanied by a series of changes in mature tissues that influence their properties and functions. Collagen, as one of the main extracellular components of cartilage, becomes highly crosslinked during aging. In this study, the aim was to examine whether a correlation exists between collagen crosslinking induced by artificial aging and mechanical properties of the temporomandibular joint (TMJ) condyle. Read More

    Inhibition of the receptor for advanced glycation promotes proliferation and repair of human periodontal ligament fibroblasts in response to high glucose via the NF-κB signaling pathway.
    Arch Oral Biol 2017 Dec 16;87:86-93. Epub 2017 Dec 16.
    Department of prosthodontics, The Oral Hospital Of Southwest Medical University, Luzhou 646000, Sichuan, China.
    Objective: To observe if inhibition of the receptor for advanced glycation endproducts (RAGE) promotes proliferation and repair of human periodontal ligament fibroblasts (hPDLFs) stimulated by high glucose. In addition, we also discuss the effects of the NF-κB signaling pathway in relation to this process.

    Methods: Primary cultured hPDLFs were exposed to either low glucose (5. Read More

    Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts.
    Arch Oral Biol 2017 Dec 6;87:79-85. Epub 2017 Dec 6.
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, United States. Electronic address:
    Objectives: Approximately 65 million adults in the US have periodontitis, causing tooth loss and decreased quality of life. Cannabinoids modulate immune responses, and endocannabinoids are prevalent during oral cavity inflammation. Targets for intervention in periodontal inflammation are cannabinoid type 1 and 2 receptors (CB1R, CB2R), particularly CB2R because its levels increase during inflammation. Read More

    Age-related changes of CD4+ T cell migration and cytokine expression in germ-free and SPF mice periodontium.
    Arch Oral Biol 2017 Dec 9;87:72-78. Epub 2017 Dec 9.
    Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Objective: Increasing age is a potential risk factor for periodontal tissue breakdown, which may be affected by commensal flora. The aim of this study evaluated age-related changes in CD4+ T cells, C-C chemokine ligand 5 (CCL5), interleukin (IL)-17A, and receptor activator of nuclear factor-kappa B ligand (RANKL) expression using germ-free (GF) and conventionally reared (SPF) mice.

    Design: GF and SPF mice at 8 (n = 6/group) and 22 weeks old (n = 6/group) were used. Read More

    EphrinB2 signaling enhances osteogenic/odontogenic differentiation of human dental pulp stem cells.
    Arch Oral Biol 2017 Dec 16;87:62-71. Epub 2017 Dec 16.
    Endodontology, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong, China; HKU Shenzhen Institute of Research and Innovation, Shenzhen, China. Electronic address:
    Objective: To investigate the role of the EphrinB2 signaling pathway in the osteogenesis/odontogenesis of human dental pulp stem cells (DPSCs).

    Design: The endogenous expression levels of EphrinB2 and its cognate receptors EphB2 and EphB4 in DPSCs were analyzed by qRT-PCR and Western blotting after 7, 14 and 21 days of osteogenic/odontogenic induction culture. Additionally, the phosphorylation of EphrinB2, EphB4 and ERK1/2 proteins at early time-points following osteogenic induction, were also investigated by Western blots. Read More

    The WNT7B protein promotes the migration and differentiation of human dental pulp cells partly through WNT/beta-catenin and c-Jun N-terminal kinase signalling pathways.
    Arch Oral Biol 2017 Dec 15;87:54-61. Epub 2017 Dec 15.
    State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No.14, Section 3, South Renmin Road, Chengdu, 610041, PR China. Electronic address:
    Objective: The aim of this study is to investigate the role of the WNT7B protein in the migration and differentiation of human dental pulp cells (HDPCs).

    Design: The effect of recombinant human WNT7B (rhWNT7B) on the proliferation and migration of HDPCs was evaluated by 5-ethynyl-2'-deoxyuridine (EdU), immunofluorescence staining of Ki67, flow cytometry and scratch assay; the differentiation of HDPCs was measured by alkaline phosphatase (ALP) staining, alizarin red staining, ALP activity, qPCR and western blot. The activation of the WNT/beta-catenin (WNT/β-catenin) and c-Jun N-terminal kinase (JNK) pathways was analysed by western blot, immunocytochemistry and dual luciferase assays. Read More

    Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review.
    Arch Oral Biol 2017 Dec 12;87:43-51. Epub 2017 Dec 12.
    Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
    Objectives: The objective of this systematic review was to evaluate information on the levels of MMP-8 in patients diagnosed with prediabetes or type 2 diabetes mellitus with periodontal disease, analyzing its validity as a possible biomarker for the diagnosis and progression of periodontal disease (PD).

    Methods: A systematic search of the following databases was performed: PubMed/Medline, CENTRAL (The Cochrane Library), EMBASE and Web of Science. Studies involving the evaluation of MMP-8 in patients with prediabetes or patients presenting type 2 diabetes mellitus concomitantly with PD were selected. Read More

    Effects of Rhodomyrtus tomentosa extract on virulence factors of Candida albicans and human neutrophil function.
    Arch Oral Biol 2017 Dec 10;87:35-42. Epub 2017 Dec 10.
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Excellence Research Laboratory on Natural products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. Electronic address:
    Objective: Candida albicans has become a major problem of oral candidiasis due to increase in antibiotic resistance. Rhodomyrtus tomentosa, a medicinal plant possessing several phytochemical constituents, has been considered as a potential source of antimicrobial and immunomodulatory agents. The aim of this study was to investigate anti-virulence and immunostimulatory activity of R. Read More

    "Omics" in oral cancer: New approaches for biomarker discovery.
    Arch Oral Biol 2017 Dec 8;87:15-34. Epub 2017 Dec 8.
    School of Medical Science and Technology, IIT Kharagpur, India. Electronic address:
    Objectives: In this review paper, we explored the application of "omics" approaches in the study of oral cancer (OC). It will provide a better understanding of how "omics" approaches may lead to novel biomarker molecules or molecular signatures with potential value in clinical practice. A future direction of "omics"-driven research in OC is also discussed. Read More

    When forensic odontology met biochemistry: Multidisciplinary approach in forensic human identification.
    Arch Oral Biol 2017 Dec 9;87:7-14. Epub 2017 Dec 9.
    Smithsonian Institution, NMNH, MRC112, Anthropology Department, 10th and Constitution Ave, NW, PO Box 37012, 20560, Washington, DC, United States; Florida International University, Department of Chemistry and Biochemistry and International Forensic Research Institute, 11200 SW 8 St. CP323, Miami, FL, 33199, United States. Electronic address:
    When human remains are found, the priority of the investigation is to ascertain the identity of the deceased. A positive identification is a key factor in providing closure for the family of the deceased; it is also required to issue the death certificate and therefore, to settle legal affairs. Moreover, it is difficult for any forensic investigation involving human remains to be solved without the determination of an identity. Read More

    Reliability of a new test food to assess masticatory function.
    Arch Oral Biol 2017 Dec 9;87:1-6. Epub 2017 Dec 9.
    Department of Prosthodontics, School of Dentistry, Faculty of Medicine and Health Sciences, University of Barcelona, Catalonia, Spain; Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. Electronic address:
    Objective: This study assessed the reliability and validity of masticatory function assessment using a new test food, Optozeta.

    Design: Thirty-five adults participated in the cross-sectional clinical part of the study; ten of them performed a retest. They performed two free-style masticatory tests consisting of five trials of 20 cycles each chewing three pieces of Optosil or Optozeta placed in a latex bag. Read More

    Dentin sialophosphoprotein expression in enamel is regulated by Copine-7, a preameloblast-derived factor.
    Arch Oral Biol 2018 Feb 6;86:131-137. Epub 2017 Dec 6.
    Department of Oral Histology-Developmental Biology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 08826, Korea. Electronic address:
    Objective: Dentin sialophosphoprotein (Dspp) is expressed in odontoblasts and transiently expressed in early ameloblasts. However, the origin of Dspp in ameloblasts remains unclear. Our previous studies demonstrated that copine-7 (CPNE7), a molecule that is secreted by the dental epithelium, is expressed in early ameloblasts and is then translocated to differentiating odontoblasts; its expression levels correlate with odontoblast differentiation under the control of Dspp expression. Read More

    Extensive phenotyping of the orofacial and dental complex in Crouzon syndrome.
    Arch Oral Biol 2018 Feb 27;86:123-130. Epub 2017 Oct 27.
    Adelaide Dental School, The University of Adelaide, Adelaide, SA 5005, Australia; Australian Craniofacial Unit, Women's and Children's Hospital, 72 King William St, Adelaide, SA 5006, Australia.
    Objectives: Fibroblast growth factor receptor 2 (FGFR2) C342Y/+ mutation is a known cause of Crouzon syndrome that is characterised by craniosynostosis and midfacial hypoplasia. Our aim was to conduct extensive phenotyping of the maxillary, mandibular and dental morphology associated with this mutation.

    Materials And Methods: Morphometric data were obtained from 40 mice, representing two genotypes (Crouzon and wild-type) and two sexes (males and females) (n=10 in each group). Read More

    Genomic integration and expression of the Aggregatibacter actinomycetemcomitans catalase gene in Aggregatibacter aphrophilus.
    Arch Oral Biol 2018 Feb 5;86:116-122. Epub 2017 Dec 5.
    Division of Periodontology, Diagnostic Sciences and Dental Hygiene, Herman Ostrow School of Dentistry, University of Southern California, 925 W 34th street, Los Angeles, CA 90089, USA. Electronic address:
    Objective: To test the hypothesis that virulence genes of Aggregatibacter actinomycetemcomitans can be expressed and confer fitness advantages in the closely related Aggregatibacter aphrophilus.

    Design: Clinical isolates of A. aphrophilus were screened for natural competence with marked genomic DNA from A. Read More

    Live cell imaging reveals different modes of cytotoxic action of extracts derived from commonly used luting cements.
    Arch Oral Biol 2018 Feb 27;86:108-115. Epub 2017 Nov 27.
    Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania.
    Objective: To compare cytotoxicity of extracts derived from commonly used luting cements: Hoffmann's Zinc Phosphate (ZPC), GC Fuji Plus Resin Modified Glass Ionomer (RMGIC) and 3M ESPE RelyX Unicem Resin Cement (RC) on primary human gingival fibroblasts (HGFs).

    Design: HGFs were exposed to different concentrations of the ZPC, RMGIC and RC extracts. The cytotoxicity was assessed with the PrestoBlue Cell Viability Reagent and viable cells were counted by a haemocytometer using the trypan blue exclusion test. Read More

    Dickkopf-1 may regulate bone coupling by attenuating wnt/β-catenin signaling in chronic apical periodontitis.
    Arch Oral Biol 2018 Feb 5;86:94-100. Epub 2017 Dec 5.
    State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics West China Hospital of Stomatology, Sichuan University, 14# 3rd Section, Renmin South Road, Chengdu, Sichuan Province, 610041, China. Electronic address:
    Objective: Alveolar bone loss is a common outcome of chronic apical periodontitis. In this study, we investigated the involvement of the Dickkopf-1-Wnt/β-catenin signaling pathway in the attenuation of osteogenic differentiation induced by Escherichia coli lipopolysaccharide, and we evaluated the use of Dickkopf-1 inhibitor and Dickkopf-1 recombinant protein to reverse bone loss in different phases of osteogenic differentiation.

    Methods: MC3T3-E1 cells grown in osteogenic medium were treated with Escherichia coli lipopolysaccharide for 24h during osteogenic induction on days 0, 1, 7, 14 and 21. Read More

    High-refined carbohydrate diet promotes detrimental effects on alveolar bone and femur microarchitecture.
    Arch Oral Biol 2018 Feb 28;86:101-107. Epub 2017 Nov 28.
    Department of Oral Surgery and Pathology, Faculty of Dentistry, Federal University of Minas Gerais, MG, Brazil. Electronic address:
    The impact of high-refined carbohydrate (HC) diet on fat accumulation, adipokines secretion and systemic inflammation is well described. However, it remains unclear whether these processes affect bone remodeling.

    Objective: To investigate the effects of HC diet in the alveolar bone and femur parameters. Read More

    Quantitative sensory response of the SCM muscle on sustained low level activation simulating co-contractions during bruxing.
    Arch Oral Biol 2018 Feb 10;86:87-93. Epub 2017 Nov 10.
    Department of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
    Objective: Bruxism is discussed as an etiological factor in the pathogenesis of orofacial and cervical pain. As the sternocleidomastoid muscle (SCM) is co-activated during clenching, our aim was to investigate, whether the muscle loading leads to peripheral or central sensitizations.

    Design: In twenty-one healthy female volunteers, somatosensory profiles of the SCM were recorded according to the test battery of the German Research Network on Neuropathic Pain (DFNS) prior to and after an isometric muscle exercise. Read More

    Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial.
    Arch Oral Biol 2018 Feb 1;86:80-86. Epub 2017 Dec 1.
    Nucleus of Periodontal Research, Dental School, University of Taubaté, Expedicionário Ernesto Pereira, 110 - Taubaté, São Paulo, Brazil. Electronic address:
    Objectives: Patients with diabetes have a poor oral health-related quality of life (OHRQoL). It is not clear if this situation could be changed with effective periodontal treatment. This study examined both patients with diabetes and systemically healthy individuals to discover the impact of a gingivitis treatment protocol on OHRQoL and its relation to objective periodontal parameters. Read More

    Aspects of the final phase of enamel formation as evidenced by observations of superficial enamel of human third molars using scanning electron microscopy.
    Arch Oral Biol 2018 Feb 21;86:72-79. Epub 2017 Nov 21.
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway; School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People's Republic of China.
    Objective: Enamel structure reflects ameloblast function. By studying the structure of the superficial enamel, information about ameloblast function toward the end of the secretory stage may be obtained.

    Design: The superficial enamel in midcoronal areas of acid-etched facio-lingual sections from human third molars was studied in the scanning electron microscope (SEM). Read More

    The use of laser Doppler flowmetry to evaluate oral soft tissue blood flow in humans: A review.
    Arch Oral Biol 2018 Feb 22;86:58-71. Epub 2017 Nov 22.
    Department of Periodontology, UIC Odontology, Nantes Dental School 1, Place Alexis-Ricordeau, 44042 Nantes Cedex 1, France. Electronic address:
    The objective of this work is to define the conditions for improving the use of laser Doppler flowmetry (LDF) and to determine the limits for the use of this technique. This article systematically reviews the literature on the evaluation of oral soft tissue blood microcirculation by LDF. We analysed the available literature through October 2016 using the database resources Medline/PubMed, the Cochrane Oral Health Group Specialist Trials Register and the ISI Web of Knowledge. Read More

    Influence of dentin pretreatment with 2.5% titanium tetrafluoride on inhibiting caries at the tooth-restoration interface in situ.
    Arch Oral Biol 2018 Feb 3;86:51-57. Epub 2017 Nov 3.
    São Leopoldo Mandic Institute and Dental Research Center, Rua José Rocha Junqueira 13, Bairro Swift, Campinas, CEP: 13045-755, São Paulo, Brazil. Electronic address:
    Objective: Investigate the effects of dentin pretreatment with 2.5% titanium tetrafluoride (TiF4) aqueous solution followed by two-step self-etching (CLE/Clearfil SE Bond) and one-step self-etching adhesive systems (SBU/Single Bond Universal) on carious lesion inhibition at the tooth-restoration interface using an in situ model.

    Design: Sixty-four cavities at the enamel-dentin junction of dental fragments were randomly distributed according to groups (n=16): 1) TiF4+CLE; 2) TiF4+SBU; 3) CLE; 4) SBU. Read More

    The effect of magnesium hydroxide-containing dentifrice using an extrinsic and intrinsic erosion cycling model.
    Arch Oral Biol 2018 Feb 14;86:46-50. Epub 2017 Nov 14.
    Universidade Federal do Ceará - UFC, Faculty of Pharmacy, Dentistry and Nursing, Monsenhor Furtado St., Fortaleza, CE, Brazil. Electronic address:
    Objective: To evaluate, in vitro, the effect of Mg(OH)2 dentifrice, and the influence of the number of experimental days, on the extrinsic (citric acid -CA) and intrinsic (hydrochloric acid -HCl) enamel erosion models.

    Design: Human enamel slabs were selected according to surface hardness and randomly assigned to 3 groups (n=9) as follows: non-fluoridated (negative control), NaF (1450ppm F- positive control) and Mg(OH)2 (2%) dentifrices. The slabs were daily submitted to a 2-h period of pellicle formation and, over a period of 5days, submitted to cycles (3×/day) of erosive challenge (CA 0. Read More

    Effect of laser activated bleaching on the chemical stability and morphology of intracoronal dentin.
    Arch Oral Biol 2018 Feb 13;86:40-45. Epub 2017 Nov 13.
    Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
    Objectives: To evaluate the effect of the bleaching with 35% hydrogen peroxide either activated or not by a 970nm diode laser on the chemical stability and dentin surface morphology of intracoronary dentin.

    Methods: Twenty-seven slabs of intracoronary dentin specimens (3×3mm) were distributed into three groups (n=9), according to surface treatment: HP - 35% hydrogen peroxide (1×4'), DL - 970nm diode laser (1×30"/0,8W/10Hz), HP+DL - 35% HP activated with 970nm diode laser (1×30"/0,8W/10Hz leaving the gel in contact to the surface for 4' after activation). Three Raman spectra from each fragment were obtained to calculate the mean intensity of peaks of inorganic component (a. Read More

    The chemokine receptor type 4 antagonist, AMD3100, interrupts experimental tooth movement in rats.
    Arch Oral Biol 2018 Feb 11;86:35-39. Epub 2017 Nov 11.
    Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
    Objective: The aim of this study was to clarify the role of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis in osteoclast accumulation, and the influence of orthodontic tooth movement (OTM) under mechanical force application to periodontal tissues, by administration of the CXCR4 antagonist AMD3100.

    Design: The upper right first molar (M1) of rats was moved mesially with a 10-g force titanium-nickel closed coil spring. Rats were treated with phosphate-buffered saline or AMD3100 (5mg/kg), which is a SDF-1 antagonist. Read More

    The risk factors related to bruxism in children: A systematic review and meta-analysis.
    Arch Oral Biol 2018 Feb 11;86:18-34. Epub 2017 Nov 11.
    Department of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, No. 199 Dong Gang West Road, Gansu, China; Gansu Provincial Maternity and Child Care Hospital, No. 143 North Road, Gansu, China.
    Objective: This systematic review was performed to determine the risk factors related to bruxism in children.

    Design: This systematic review was conducted with reporting in agreement to the PRISMA statement and according to guidelines from the Cochrane Handbook for Systematic Reviews of Interventions. We conducted a systematic search of seven online databases, with the last search updated on 1st October 2016. Read More

    Risk factors for tooth loss in middle and older age after up to 10 years: An observational cohort study.
    Arch Oral Biol 2018 Feb 6;86:7-12. Epub 2017 Nov 6.
    Dental School, Department of Prosthetic Dentistry, University of Heidelberg, Germany.
    Objective: The objective of this research was to identify risk factors for tooth loss in two birth cohorts, quinquagenarians and septuagenarians, after up to 10 years of clinical observation.

    Design: One hundred and twenty-three participants were recruited from the Interdisciplinary Study of Adult Development (ILSE) and examined at baseline and up to 10 years after. Thirty-nine and 84 participants belonged to the older (OC; born in 1930/32) cohort and younger (YC; born in 1950/52) cohort, respectively. Read More

    Secretoneurin and PE-11 immunoreactivity in the human dental pulp.
    Arch Oral Biol 2018 Feb 9;86:13-17. Epub 2017 Nov 9.
    Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
    Objective: To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin gene-related peptide were performed to confirm the sensory origin of the peptidergic nerves in the dental pulp.

    Design: The concentrations of secretoneurin and PE-11 were determined by highly sensitive radioimmunoassays in extracts of dental pulps, the molecular form of secretoneurin immunoreactivities by RP-HPLC with subsequent radioimmunoassay and colocalization studies with calcitonin gene-related peptide were performed by double immunofluorescence. Read More

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