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    9056 results match your criteria Archives of Oral Biology[Journal]

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    Conditioning of human salivary flow using a visual cue for sour candy.
    Arch Oral Biol 2018 May 14;92:90-95. Epub 2018 May 14.
    Department of Nutrition Science and Department of Food Science, 700 W State St, Purdue University, West Lafayette IN, USA. Electronic address:
    Objective: Although the "mouthwatering" to sight, smell, or thought of food is commonly accepted in food and nutrition research, the concept of mouthwatering and human salivary flow conditioning is not well accepted in salivary research. The objective of this study was to revisit whether human salivary flow could be classically conditioned to a previously neutral stimulus.

    Design: Sour candy or a non-food control in opaque containers were presented to healthy participants (n = 8). Read More

    Hypothesis-driven versus hypothesis-free approaches to the identification of genes for cleft lip and palate.
    Arch Oral Biol 2018 May 16;92:88-89. Epub 2018 May 16.
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, PA 15261, USA.
    Much progress has been made in understanding the genetic contributions to isolated forms of cleft lip and palate, however this effort is yet to be translated to enhanced genetic counseling or prevention strategies. Interest in the topic was renewed with the ability to perform genome-wide genotyping and after a few of those relatively larger scale studies, many are considering more targeted efforts and to focus on specific genes and/or loci. Here we discuss this crossroad and suggest targeted approaches and rethought clinical descriptions are a better way to move the field forward. Read More

    Screening methylation of DNA repair genes in the oral mucosa of chronic smokers.
    Arch Oral Biol 2018 May 1;92:83-87. Epub 2018 May 1.
    Department of Biosciences and Oral Diagnosis, São Paulo State University (Unesp), Institute of Science and Technology, São José dos Campos, Brazil.
    Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers.

    Design: Two groups were formed: Group 1: 16 smokers with consumption of 20 cigarettes/day for at least 10 years; and Group 2: 10 non-smoking. Exfoliative cytology of the tongue was performed, and the extracted DNA was treated by enzymes. Read More

    A cone-beam computed tomography study of the mesial cervical concavity of maxillary first premolars.
    Arch Oral Biol 2018 May 7;92:79-82. Epub 2018 May 7.
    Department of Endodontics, Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institue of Stomatology, National Clinical Research Center of Stomatology, China. Electronic address:
    Objective: To investigate the mesial cervical concavity of maxillary first premolars and its relationship with root and canal configuration using cone-beam computed tomography (CBCT).

    Design: Images of maxillary first premolars (n = 1056) were collected from patients (n = 601) who had undergonein vivo CBCT scanning. The root and canal number and morphology were evaluated. Read More

    Inhibition of VEGF gene expression in osteoblast cells by different NSAIDs.
    Arch Oral Biol 2018 May 9;92:75-78. Epub 2018 May 9.
    Instituto Investigación Biosanitaria, ibs. Granada, Spain; Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain.
    Objective: To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations.

    Design: Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 μM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24 h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group). Read More

    Polymorphonuclear neutrophil integrity and functionality are preserved when exposed to saliva.
    Arch Oral Biol 2018 May 1;92:68-74. Epub 2018 May 1.
    Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands; OprisDent SRL, Sibiu, Romania. Electronic address:
    Objective: Polymorphonuclear neutrophils (PMNs) are the most abundant innate immune cells and are also important effectors in the maintenance of oral health. However, little is known about the effects of saliva on the PMN. We therefore aimed to investigate the effect of saliva on the PMNs' morphology and functioning. Read More

    Dynamic changes of Th1/Th2/Th17 cytokines and human beta defensin 2 in HIV-infected patients with oral candidiasis during the first year of highly active anti-retroviral therapy.
    Arch Oral Biol 2018 May 3;92:62-67. Epub 2018 May 3.
    Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, China. Electronic address:
    Objective: To investigate the change of Th1/Th2/Th17 cytokines and human beta defensin 2 (HBD-2) in HIV-infected patients with oral candidiasis (OC) and gather information about OC-specific immunity.

    Design: During the 1st year of highly active anti-retroviral therapy (HAART), 25 HIV-infected patients were followed up at the baseline, 3rd, 6th, 12th month. At each visit, oral manifestations were examined; oral rinses were collected and cultured for Candida; peripheral venous blood was taken to determine CD4 + T cell counts and HIV RNA viral load (VL); both unstimulated whole saliva and peripheral venous blood were taken to determine cytokine (IL-4, IL-17(A/F), IFN-γ) and HBD-2 levels. Read More

    An exploratory study of the factors related to mouth breathing syndrome in primary school children.
    Arch Oral Biol 2018 Mar 26;92:57-61. Epub 2018 Mar 26.
    Department of Pediatric Dentistry, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
    Objective: Mouth breathing syndrome (MBS) is defined as a set of signs and symptoms that may be completely or incompletely present in subjects who, for various reasons, replace the correct pattern of nasal breathing with an oral or mixed pattern. It is important to identify the relevant factors affecting MBS in order to diagnose its cause since breathing obstructions can result from multiple factors. The purpose of this study is to clarify the relevant factors and the interrelationships between factors affecting MBS among children. Read More

    Salivary immunoglobulin levels in juvenile autoimmune hepatitis.
    Arch Oral Biol 2018 May 6;92:51-56. Epub 2018 May 6.
    Federal University of Ceará, Brazil.
    Aims: The aim of the present study was to investigate the presence of immunoglobulins (Ig) in whole saliva from patients affected by autoimmune hepatitis (AIH).

    Design: Twelve individuals with AIH and 12 healthy individuals without (CON) autoimmune hepatitis, aged 8-18 years, participated in this study. Non-stimulated whole saliva was collected and centrifuged. Read More

    Assessment of genotyping tools applied in genetic susceptibility studies of periodontal disease: A systematic review.
    Arch Oral Biol 2018 Apr 30;92:38-50. Epub 2018 Apr 30.
    Grupo de Medicina Xenómica, Centro Nacional de Genotipado - Plataforma de Recursos Biomoleculares y Bioinformáticos - Instituto de Salud Carlos III (CeGen-PRB2-ISCIII), Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruña, Spain; Grupo de Medicina Xenómica, CIBERER, Fundación Pública Galega de Medicina Xenómica - SERGAS Santiago de Compostela, A Coruña, Spain.
    Objective: A systematic review to evaluate the various genotyping tools and study strategies employed to define genetic susceptibility to periodontitis.

    Methods: The review was performed in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The search for publications referring to the genetic bases of periodontal disease was performed on the MEDLINE-PubMed and Cochrane Library databases, on trials registers, and on the web pages of regulatory agencies. Read More

    Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma.
    Arch Oral Biol 2018 Apr 30;92:32-37. Epub 2018 Apr 30.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:
    Purpose: This study evaluated the role of anti-tumor immune response of curcumin on tongue squamous cell carcinama (TSCC).

    Experimental Design: Cell lines (Cal 27, FaDu) and animal model (4NQO mice model) were uesd in this study. The MTT assay was used to detecte cell proliferation. Read More

    Biochemical characterization of a recombinant Lactobacillus acidophilus strain expressing exogenous FomA protein.
    Arch Oral Biol 2018 Apr 30;92:25-31. Epub 2018 Apr 30.
    Department of Preventive Dentistry, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, China. Electronic address:
    In previous research, to combine the immunogenicity of Fusobacterium nucleatum (F. nucleatum) and the probiotic properties of Lactobacillus acidophilus (L. acidophilus), we constructed a FomA-expressing L. Read More

    Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats.
    Arch Oral Biol 2018 Apr 30;92:18-24. Epub 2018 Apr 30.
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, FL, 32611, United States; Pain Research and Intervention Center of Excellence, University of Florida, 1329 SW 16th Street, Gainesville, FL, 32608, United States; Institute for Cell Engineering and Regenerative Medicine, University of Florida, 300 Weil Hall, 1949 Stadium Road, Gainesville, FL, 32611, United States; Nanoscience Institute for Medical and Engineering Technology, University of Florida, 1041 Center Dr, Gainesville, FL, 32611, United States. Electronic address:
    Objective: To assess changes in orofacial tactile sensitivity and gnawing related to capsaicin-mediated cutaneous, myogenic, and arthrogenic nociception in the rat.

    Design: After recovery from anesthesia, orofacial tactile sensitivity and gnawing were assessed using operant testing methods following capsaicin application. Twenty female CD-Hairless rats were tested with bilateral capsaicin cream application to the cheek or with isoflurane anesthesia alone. Read More

    Sources of free radicals and oxidative stress in the oral cavity.
    Arch Oral Biol 2018 May 1;92:8-17. Epub 2018 May 1.
    Department of Conservative Dentistry, Medical University Bialystok, Sklodowskiej M.C. 24a Str., 15-274 Bialystok, Poland. Electronic address:
    Objective: An oral cavity is a place especially susceptible to oxidative damage. It is subjected to many environmental pro-oxidative factors or factors that have the ability to generate reactive oxygen species (ROS). The aim of this article is to present the main sources of ROS and oxidative stress in the oral environment. Read More

    Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children.
    Arch Oral Biol 2018 Apr 20;92:1-7. Epub 2018 Apr 20.
    Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil. Electronic address:
    Objective: This replication study aimed to evaluate an association between caries experience and polymorphisms in DEFB1 and miRNA202 in two different Brazilian groups.

    Design: The population consisted in 312 Brazilian children. Genomic DNA for was extracted from buccal cells isolated from saliva. Read More

    Whole exome sequencing in an Italian family with isolated maxillary canine agenesis and canine eruption anomalies.
    Arch Oral Biol 2018 Jul 21;91:96-102. Epub 2018 Apr 21.
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. Electronic address:
    Objective: The aim of this study was the clinical and molecular characterization of a family segregating a trait consisting of a phenotype specifically involving the maxillary canines, including agenesis, impaction and ectopic eruption, characterized by incomplete penetrance and variable expressivity.

    Design: Clinical standardized assessment of 14 family members and a whole-exome sequencing (WES) of three affected subjects were performed. WES data analyses (sequence alignment, variant calling, annotation and prioritization) were carried out using an in-house implemented pipeline. Read More

    Proteomics and immunohistochemistry identify the expression of α-cardiac myosin heavy chain in the jaw-closing muscles of sooty mangabeys (order Primates).
    Arch Oral Biol 2018 Jul 3;91:103-108. Epub 2018 Feb 3.
    Department of Basic Science, College of Osteopathic Medicine, Touro University, Vallejo, CA, USA. Electronic address:
    Objective: The jaw-closing muscles of humans and nonprimate mammals express alpha-cardiac fibers but MyHC α-cardiac has not been identified in the jaw adductors of nonhuman primates. We determined whether MyHC α-cardiac is expressed in the superficial masseter and temporalis muscles of the sooty mangabey (Cercocebus atys), an African Old World monkey that specializes on hard seeds.

    Design: LC-MS/MS based proteomics was used to identify the presence of MyHC Iα. Read More

    Gene-gene interaction for nonsyndromic cleft lip with or without cleft palate in Chilean case-parent trios.
    Arch Oral Biol 2018 Jul 18;91:91-95. Epub 2018 Apr 18.
    Sección de Genética, Hospital Clínico Universidad de Chile, Santos Dumont #999, Santiago, Chile; Unidad de Neonatología, Hospital Clínico Universidad de Chile, Santos Dumont #999, Santiago, Chile; Unidad de Genética, Hospital Dr. Sótero del Río, Concha y Toro #3459, Santiago, Chile.
    Objective: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a birth defect for which several genes susceptibility genes been proposed. Consequently, it has been suggested that many of these genes belong to common inter-related pathways during craniofacial development gene-gene interaction. We evaluated the presence of gene-gene interaction for single nucleotide polymorphisms within interferon regulatory factor 6 (IRF6), muscle segment homeobox 1 (MSX1), bone morphogenetic protein 4 (BMP4) and transforming growth factor 3 (TGFB3) genes in NSCL/P risk in Chilean case-parent trios. Read More

    Cementum regeneration using stem cells in the dog model: A systematic review.
    Arch Oral Biol 2018 Jul 3;91:78-90. Epub 2018 Apr 3.
    School of Dentistry, University of Alberta, Edmonton, Alberta, Canada.
    Objective: Restoring lost tissues of the periodontium, such as cementum, is essential in reducing the risk of tooth loss due to periodontitis and/or severe root resorption. Stem cell therapy is a regenerative strategy in cementum regeneration. This systematic review aimed to analyze the effect of various stem cells and their transplantation method on cementum regeneration in the dog model. Read More

    Determining chewing efficiency using a solid test food and considering all phases of mastication.
    Arch Oral Biol 2018 Jul 10;91:63-77. Epub 2018 Apr 10.
    School of Food Science & Biotechnology, Zhejiang Gongshang University, Xiasha, Hangzhou, China. Electronic address:
    Objectives: Following chewing a solid food, the median particle size, X, is determined after N chewing cycles, by curve-fitting of the particle size distribution. Reduction of X with N is traditionally followed from N ≥ 15-20 cycles when using the artificial test food Optosil, because of initially unreliable values of X. The aims of the study were (i) to enable testing at small N-values by using initial particles of appropriate size, shape and amount, and (ii) to compare measures of chewing ability, i. Read More

    Cytotoxicity of novel fluoride solutions and their influence on mineral loss from enamel exposed to a Streptococcus mutans biofilm.
    Arch Oral Biol 2018 Jul 13;91:57-62. Epub 2018 Apr 13.
    Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:
    Objective: This study evaluated the cytotoxicity, antimicrobial activity and in vitro influence of new fluoridated nanocomplexes on dental demineralization.

    Design: The nanocomplexes hydroxypropyl-β-cyclodextrin with 1% titanium tetrafluoride (TiF) and γ-cyclodextrin with TiF were compared to a positive control (TiF), a blank control (without treatment) and negative controls (hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, deionized water), following 12- and 72-hour complexation periods. The cytotoxicity was assessed using the neutral red dye uptake assay at T1-15 min, T2-30 min and T3-24 h. Read More

    Long-term evaluation of the stability of dentin matrix following treatments with aqueous solutions of titanium tetrafluoride at different concentrations.
    Arch Oral Biol 2018 Jul 10;91:51-56. Epub 2018 Apr 10.
    Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Zip Code: 60612, IL, USA. Electronic address:
    Objective: The purpose of this study was to investigate the effects of aqueous solutions of different concentrations of titanium tetrafluoride (TiF) on dentin matrix stability up to six months.

    Design: Dentin specimens prepared from fifteen nonerupted molars were demineralized and randomly distributed into groups: 2.5% TiF, 4% TiF 1000 ppm NaF, and control (distilled water). Read More

    Differential effects of natural Curcumin and chemically modified curcumin on inflammation and bone resorption in model of experimental periodontitis.
    Arch Oral Biol 2018 Jul 10;91:42-50. Epub 2018 Apr 10.
    Department of Restorative Dentistry School of Dentistry of Riberão Preto University of São Paulo Riberão Preto SP Brazil. Electronic address:
    Objective: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation in a murine model of experimental periodontal disease.

    Design: Fifty male rats were distributed among the following treatment groups: (i) 2% carboxymethylcellulose, (ii) CMC2. Read More

    Study of virulence factor of Candida species in oral lesions and its association with potentially malignant and malignant lesions.
    Arch Oral Biol 2018 Jul 19;91:35-41. Epub 2018 Feb 19.
    Dpto. de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina.
    Objective: The aim of this study was to explore the association between malignant and premalignant lesions and the virulence factor profile of Candida spp. recovered from different oral lesions.

    Design: Candida spp. Read More

    Hemifacial microsomia (oculo-auriculo-vertebral spectrum) in an individual from the Teramo Sant'Anna archaeological site (7th-12th centuries of the Common Era, Italy).
    Arch Oral Biol 2018 Jul 6;91:23-34. Epub 2018 Apr 6.
    Operative Unit of Anthropology, Department of Medicine and Aging Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Piazza Trento e Trieste 1, 66100 Chieti, Italy.
    Background: This study is based in an analysis of the skeletal remains of an adult male from the Teramo Sant'Anna archaeological site (7th-12th centuries of the Common Era, Teramo, Italy).

    Results And Discussion: The individual shows distinct abnormalities that principally involve asymmetric hypoplasia and dysmorphogenesis of the facial skeleton. The combination of these findings and the absence of abnormalities of the spine strongly suggest diagnosis of the congenital malformation known as hemifacial microsomia. Read More

    Hydroalcoholic extracts of Myracrodruon urundeuva All. and Qualea grandiflora Mart. leaves on Streptococcus mutans biofilm and tooth demineralization.
    Arch Oral Biol 2018 Jul 6;91:17-22. Epub 2018 Apr 6.
    Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Al. Octávio Pinheiro Brisolla 9-75, Bauru, São Paulo, Brazil. Electronic address:
    Objectives: This study evaluated the effect of the hydroalcoholic extracts of Myracrodruon urundeuva All. and Qualea grandiflora Mart. leaves (alone or combined) on the viability of Streptococcus mutans biofilm and on the prevention of enamel demineralization. Read More

    Exendin-4 relieves the inhibitory effects of high glucose on the proliferation and osteoblastic differentiation of periodontal ligament stem cells.
    Arch Oral Biol 2018 Jul 27;91:9-16. Epub 2018 Mar 27.
    Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
    Background: With the impaired regenerative potential in patients with diabetes mellitus (DM), Periodontal ligament stem cells (PDLSCs) are regarded as an attractive source of stem cells for periodontal cytotherapy. Recent studies have shown that Exendin-4 (Ex-4) exerts cell-protective effects and bone remodeling ability on many types of cells. The aim of this study was to investigate whether Ex-4 alleviates the inhibition of high glucose on the proliferation and osteogenic differentiation of PDLSCs. Read More

    A comprehensive analysis of human dental pulp cell spheroids in a three-dimensional pellet culture system.
    Arch Oral Biol 2018 Jul 15;91:1-8. Epub 2018 Feb 15.
    Department of Biohybrid & Medical Textiles, Institute of Applied Medical Engineering, Helmholtz-Institute of Biomedical Engineering, RWTH Aachen University, Aachen, Germany. Electronic address:
    Objective: Three-dimensional (3D) cell culture methods are of high importance to studies of biological processes. This is particularly the case with spheroid cultures, which create 3D cell aggregates without the use of exogenous materials. Compared to conventional monolayer cultures, cellular spheroid cultures have been demonstrated to improve multilineage potential and extracellular matrix production. Read More

    Natural saliva as an adjuvant in a secondary caries model based on Streptococcus mutans.
    Arch Oral Biol 2018 Jun 27;90:138-143. Epub 2018 Mar 27.
    Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany. Electronic address:
    Objective: Two factors for secondary caries formation were evaluated using an artificial biofilm model, saliva as additive in culture medium and bonding procedures of composite materials for artificial gap creation.

    Design: Standardized cavities were prepared in bovine tooth samples (n = 44), treated with two different bonding pretreatments, restored and after artificial ageing incubated with Streptococcus mutans in a Mueller-Hinton-Broth-Sugar medium with or without human saliva for seven days. Secondary caries formation was analyzed using confocal laser scanning microscopy and transversal microradiography. Read More

    Spectral components in electromyograms from four regions of the human masseter, in natural dentate and edentulous subjects with removable prostheses and implants.
    Arch Oral Biol 2018 Jun 26;90:130-137. Epub 2018 Mar 26.
    Laboratorio de Biomecánica, Kinesiología y Cineantropometría, Universidad Pablo de Olavide, Carretera de Utrera km 1, Seville, Spain.
    Objective: To compare the frequency or spectral components between different regions of the superficial masseter in young natural dentate and total edentulous older adults rehabilitated with removable prostheses and fixed-implant support. A secondary objective was to compare these components between the three groups.

    Design: 21 young natural dentate and 28 edentulous (14 with removable prostheses and 14 with fixed-implant support) were assessed. Read More

    Reduced heart rate variability and increased saliva cortisol in patients with TMD.
    Arch Oral Biol 2018 Jun 23;90:125-129. Epub 2018 Mar 23.
    Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:
    Temporomandibular disorders (TMD) are the most common source of non-dental pain. The pathogenesis of TMD is multifactorial, involving biological, psychological and behavioral factors. Those factors are involved with alterations of the autonomic nervous system (ANS) and stressful conditions. Read More

    Expression and localization of phosphodiesterase 2A in the submandibular gland of mice.
    Arch Oral Biol 2018 Jun 20;90:91-99. Epub 2018 Mar 20.
    Department of Histology and Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. Electronic address:
    Objectives: Phosphodiesterases comprise a superfamily of enzymes that hydrolyze and inactivate cyclic AMP (cAMP) and/or cyclic GMP (cGMP), thereby regulating cellular signaling mechanisms. We herein investigated the production of phosphodiesterase 2A (PDE2A) in the mouse submandibular gland.

    Design: The expression and localization of the mRNA and protein of PDE2A were examined in the submandibular gland of male and female mice using the reverse transcription-polymerase chain reaction, in situ hybridization, Western blotting, and immunohistochemistry. Read More

    Individuality of masticatory performance and of masticatory muscle temporal parameters.
    Arch Oral Biol 2018 Jun 20;90:113-124. Epub 2018 Mar 20.
    Department of Biologic and Materials Sciences, 1011 N. University Ave., School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA. Electronic address:
    Objective: Mammalian mastication serves to improve intra-oral food reduction. Insufficient food reduction creates potential swallowing problems, whereas over-reduction may accelerate tooth wear and increase feeding time. Either extreme has consequences. Read More

    Clinical duration of eruption of deciduous teeth in Jordanian children: A cross-sectional study.
    Arch Oral Biol 2018 Jun 21;90:86-90. Epub 2018 Mar 21.
    Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan; School of Dentistry and Health Sciences, Charles Strut University, Boorooma St, Wagga Wagga, NSW, 2678, Australia. Electronic address:
    Objective: The aim of this study was to investigate the clinical duration of eruption (CDE) for deciduous teeth in Jordanian children, from the moment of gingival emergence until functional occlusal contact.

    Design: This cross-sectional study included 1988 children (885 females, 1103 males) aged 1-45 months examined for deciduous tooth emergence. Through probit regression analysis (SPSS Version 16. Read More

    Surface free energy of enamel treated with sodium hexametaphosphate, calcium and phosphate.
    Arch Oral Biol 2018 Jun 20;90:108-112. Epub 2018 Mar 20.
    São Paulo State University (Unesp), School of Dentistry, Araçatuba, Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193 Araçatuba, SP, Cep 16015-050, Brazil. Electronic address:
    Objective: This study evaluated the capacity of sodium hexametaphosphate (HMP) at different concentrations to alter the surface properties of dental enamel in order to increase calcium and phosphate adsorption.

    Design: Bovine enamel blocks (4 mm × 4 mm, n = 144, 12/group) were divided: 0%; 0.25%; 0. Read More

    The role of Hedgehog signaling in cementoblast differentiation.
    Arch Oral Biol 2018 Jun 21;90:100-107. Epub 2018 Mar 21.
    Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea. Electronic address:
    Objective: It has been well known that Hedgehog (Hh) signaling plays an important role in bone development, however, its function in cementogenesis has not yet been reported. This study was intended to elucidate the role of Hh signaling in cementoblast differentiation.

    Design: Expression changes of various Hh signaling components and levels of skeletogenic markers (alkaline phosphatase, osteocalcin, osteopontin) and osteogenic transcription factors (RUNX2, Osterix) by Hh signaling modulators during OCCM-30 cementoblast differentiation were determined by quantitative real-time reverse transcriptase polymerase chain reaction. Read More

    Oral spray containing plant-derived compounds is effective against common oral pathogens.
    Arch Oral Biol 2018 Jun 6;90:80-85. Epub 2018 Mar 6.
    Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
    Objectives: Plant-derived compounds are a good source of therapeutic agents and inhibitors of inflammatory process. Dental caries, periodontal diseases and candidiasis are common oral infections caused by virulent biofilms. The objectives of this study were to develop oral spray containing plant-derived compounds; α-mangostin (α-MG) and/or lawsone methyl ether (2-methoxy-1,4-naphthoquinone) (LME) and determine its antimicrobial, anti-biofilm, and anti-inflammatory activities. Read More

    Evaluation of interleukin-1β level and oxidative status in gingival crevicular fluid during rapid maxillary expansion.
    Arch Oral Biol 2018 Jun 6;90:74-79. Epub 2018 Mar 6.
    Department of Biochemistry, Faculty of Medicine, Istanbul Altinbas University, Mahmutbey Dilmenler Caddesi, No:26, 34217 Bağcılar, Istanbul, Turkey. Electronic address:
    Objectives: The levels of interleukin-1β (IL-1β), nitric oxide (NO), total antioxidant capacity (TAC), and total oxidant status (TOS) in gingival crevicular fluid (GCF) were determined during rapid maxillary expansion (RME) treatment.

    Materials And Methods: Fourteen patients (10-13 years old) were included. A modified hyrax appliance was used for the treatment. Read More

    Analysis of proteoglycan expression in human dental pulp.
    Arch Oral Biol 2018 Jun 10;90:67-73. Epub 2018 Mar 10.
    Departamento de Bioquimica da Universidade Federal de São Paulo, Disciplina de Biologia Molecular, Rua 3 de Maio 100, 04044-020, São Paulo, Brazil. Electronic address:
    Proteoglycans are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans. They can be located on the extracellular matrix, cell membrane or intracellular granules. To date, few studies have reported the presence of proteoglycans in human dental pulp. Read More

    Comparison of peri-implant soft tissues in submerged versus transmucosal healing: A split mouth prospective immunohistochemical study.
    Arch Oral Biol 2018 Jun 12;90:61-66. Epub 2018 Mar 12.
    Department of Dentistry, European University of Valencia, Valencia, Spain; Public Dental Health Service, Arnau de Vilanova Hospital, Valencia, Spain.
    Objective: The present split-mouth prospective study involves an immunohistochemical evaluation of peri-implant soft tissue healing after the osseointegration period, comparing submerged and transmucosal approaches using two-piece implant systems. The null hypothesis was that both surgical procedures elicit a similar immune response of the peri-implant soft tissues.

    Design: Thirty-one healthy patients were included in this study, in which two implants were placed in the right and left maxillary pre-molar regions. Read More

    Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome.
    Arch Oral Biol 2018 Jun 6;90:53-60. Epub 2018 Mar 6.
    Division of Operative Dentistry, Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan. Electronic address:
    Objective: Marfan syndrome (MFS) is a systemic connective tissue disorder caused by insufficient fibrillin-1 (FBN-1), a major component of microfibrils that controls the elasticity and integrity of connective tissues. FBN-1 insufficiency in MFS leads to structural weakness, which causes various tissue disorders, including cardiovascular and periodontal disease. However, the role of FBN-1 insufficiency in the destruction and regeneration of connective tissue has not yet been clarified. Read More

    Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment.
    Arch Oral Biol 2018 Jun 8;90:45-52. Epub 2018 Jan 8.
    School of Dentistry of Campo Grande, Universidade Federal do Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
    Objective: This case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients.

    Design: Twenty-eight dentate patients with head and neck cancer submitted to RT were included in the study. Read More

    Remineralizing effect of a fluoridated gel containing sodium hexametaphosphate: An in vitro study.
    Arch Oral Biol 2018 Jun 3;90:40-44. Epub 2018 Mar 3.
    São Paulo State University (Unesp), School of Dentistry, Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193, Araçatuba, SP, Cep 16015-050, Brazil. Electronic address:
    Objectives: To evaluate in vitro the effect of neutral pH topical gels with reduced fluoride concentration (F), supplemented or not with sodium hexametaphosphate (HMP) on the remineralization of dental enamel, using a pH-cycling model. Materials and methods Bovine enamel blocks with caries-like lesions were randomly treated with five gels (n = 24/group): without F/HMP (Placebo); 4500 ppm F (4500F), 4500F plus 9% HMP (4500F + HMP); 9000 ppm F (9000F); and 12,300 ppm F (Acid gel). After pH-cycling, the percentage of surface hardness recovery (%SHR), integrated loss of subsurface hardness (ΔKHN), and concentrations of loosely- (CaF) and firmly-bound (FA) fluoride formed and retained in/on enamel were determined. Read More

    The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.
    Arch Oral Biol 2018 Jun 7;90:33-39. Epub 2018 Feb 7.
    Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA. Electronic address:
    Objective: The bone morphogenetic proteins (BMPs) play crucial roles in tooth development. However, several BMPs retain expression in the dentin of the fully patterned and differentiated tooth. We hypothesized that BMP signaling therefore plays a role in the function of the differentiated odontoblast, the job of which is to lay down and mineralize the dentin matrix. Read More

    Inhibition of methionine gamma lyase deaminase and the growth of Porphyromonas gingivalis: A therapeutic target for halitosis/periodontitis.
    Arch Oral Biol 2018 Jun 1;90:27-32. Epub 2018 Mar 1.
    Department of Biochemistry, College of Medical Sciences and College of Allopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL-33328, United States. Electronic address:
    Background And Objectives: Pathogenic infections caused by Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia can result in the production of volatile sulfur compounds (VSC's) and other toxic compounds from methionine catabolism that can lead to halitosis and periodontitis. Our aim is to block the activity of methionine gammalyase-deaminase (Mgld) of methionine catabolism to prevent halitosis/periodontitis.

    Designs: Cloned, expressed, Mgld protein was tested for purity by SDS-PAGE and western blotting. Read More

    pH changes of mixed biofilms of Streptococcus mutans and Candida albicans after exposure to sucrose solutions in vitro.
    Arch Oral Biol 2018 Jun 6;90:9-12. Epub 2018 Mar 6.
    São Paulo State University (Unesp), School of Dentistry, Department of Pediatric Dentistry and Public Health, 16015-050, Araçatuba, São Paulo, Brazil. Electronic address:
    Objective: This study aimed to standardize an in vitro experimental model able to reproduce the pH changes that occur in dental biofilm under in vivo conditions, using a mixed biofilm of Streptococcus mutans and Candida albicans.

    Design: Biofilms were developed for 96 h, and exposed to three different concentrations of sucrose (10, 20 or 30%) during 1, 3 or 5 min. The pH was measured before exposure to sucrose, immediately after its removal from the biofilms, and at 1, 3, 5 and 10 min after removal. Read More

    Functional and molecular characterization of transmembrane intracellular pH regulators in human dental pulp stem cells.
    Arch Oral Biol 2018 Jun 6;90:19-26. Epub 2018 Mar 6.
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan; Department of Pharmacology, National Defense Medical Center, Taipei 114, Taiwan. Electronic address:
    Objective: Homeostasis of intracellular pH (pH) plays vital roles in many cell functions, such as proliferation, apoptosis, differentiation and metastasis. Thus far, Na-H exchanger (NHE), Na-HCO co-transporter (NBC), Cl/HCO exchanger (AE) and Cl/OH exchanger (CHE) have been identified to co-regulate pH homeostasis. However, functional and biological pH-regulators in human dental pulp stem cells (hDPSCs) have yet to be identified. Read More

    Relationship between severity of periodontitis and masseter muscle activity during waking and sleeping hours.
    Arch Oral Biol 2018 Jun 1;90:13-18. Epub 2018 Mar 1.
    Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8525, Japan.
    Objective: This study was conducted to investigate whether the masseter muscle activity shows any specific pattern in relation to the severity of periodontitis.

    Design: Sixteen subjects with no or mild periodontitis (NMP group) and 15 subjects with moderate or severe periodontitis (MSP group) were enrolled. Plasma IgG antibody titer was examined using Porphyromonas gingivalis as a bacterial antigen. Read More

    DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.
    Arch Oral Biol 2018 Jun 6;90:1-8. Epub 2018 Mar 6.
    Department of Oral Radiation Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:
    Objective: The objective of this study was to characterize the DNA damage response in two human oral cancer cell lines following X-irradiation.

    Design: To visualize radiation-induced cell cycle alterations, two human oral cancer cell lines, HSC3 and HSC4, expressing fluorescent ubiquitination-based cell cycle indicator (Fucci) were established in this study. G2 arrest kinetics following irradiation were obtained from two-color flow cytometric analysis and pedigrees of Fucci fluorescence. Read More

    Systematic review of wound healing biomarkers in peri-implant crevicular fluid during osseointegration.
    Arch Oral Biol 2018 May 22;89:107-128. Epub 2018 Feb 22.
    Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Gonçalves Chaves Street 457, 96015-560 Pelotas, RS, Brazil. Electronic address:
    Objective: To quantify and characterize the role of biomarkers in peri-implant crevicular fluid (PICF) at each stage of healing during osseointegration.

    Design: This systematic review was performed in accordance with PRISMA guidelines using several databases: MedLine (PubMed), Embase, ISI Web of Science, Scopus, and Cochrane Library. Medical subject headings and their indexers were used with no other limitations until December 2017. Read More

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