9,599 results match your criteria Archives of Oral Biology[Journal]


In vitro anticariogenic and antibiofilm activities of toothpastes formulated with essential oils.

Arch Oral Biol 2020 Jul 9;117:104834. Epub 2020 Jul 9.

Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil. Electronic address:

Objective: This study aimed to assess the antibacterial and antibiofilm effects of essential oils and herbal toothpastes against bacteria associated with oral diseases.

Methods: The minimum inhibitory concentration (MIC) and antibiofilm activity of 13 essential oils against Staphylococcus aureus, Streptococcus mutans, Lactobacillus lactis, and Enterococcus faecalis. were determined. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104834DOI Listing

Regulation of mucin 1 expression and its relationship with oral diseases.

Arch Oral Biol 2020 Jul 1;117:104791. Epub 2020 Jul 1.

Department of Oral Diagnostic Sciences, Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland, Kuopio Campus, Finland. Electronic address:

Objective: The aim of this study is to describe the polymorphic mucin 1 (MUC1), and to provide an overview of the known complex and multiple functions of MUC1 in normal oral mucosa and oral mucosal lesions in compromised situations as well as exploring the challenges associated with the heterogeneous nature of MUC1. We will review the current knowledge and provide insights into the future management possibilities of using MUC1 as a therapeutic agent.

Methods: A literature search of the electronic databases included MEDLINE (1966 -December 2019) and hand searches of cross-references were undertaken using terms related to mucins, MUC1. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104791DOI Listing

Influence of titanium and zirconia modified surfaces for rapid healing on adhesion and biofilm formation of Staphylococcus epidermidis.

Arch Oral Biol 2020 Jun 22;117:104824. Epub 2020 Jun 22.

Pontifical Catholic University of Rio Grande Do Sul (PUCRS), School of Health and Life Sciences, Immunology and Microbiology Laboratory, Av. Ipiranga, P.O. Box 6681, 90619-900, Porto Alegre, Brazil.

Objective: Surface alterations have been employed to enhance the osseointegration process in biomedical implants. However, these modifications may influence bacterial adhesion in different ways. Therefore, this study developed five different surfaces and evaluated the Staphylococcus epidermidis growth in early (1 h) and late (24 h) contact. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104824DOI Listing

The anti-caries efficacy of three fluoride compounds at increasing maturation of a microcosm biofilm.

Arch Oral Biol 2020 May 30;117:104781. Epub 2020 May 30.

Indiana University, School of Dentistry, Department of Cariology, Operative Dentistry and Dental Public Health, 415 Lansing Street, Indianapolis, IN, 46202, USA. Electronic address:

Objective: To explore the anti-caries efficacy of three fluoride compounds at increasing maturation of a microcosm biofilm.

Design: Microcosm biofilm, obtained from saliva collected from three donors (IRB #1406440799), was grown on enamel samples (n = 18/group) for 24-h (Brain Heart Infusion; 0.2 % sucrose). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104781DOI Listing

Lactobacillus reuteri associated with scaling and root planing in the treatment of periodontitis in rats submitted to chemotherapy.

Arch Oral Biol 2020 Jun 24;117:104825. Epub 2020 Jun 24.

Periodontics Division, Department of Diagnosis and Surgery, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil. Electronic address:

Objective: The aim of this study was to evaluate the effects of Lactobacillus reuteri applied locally or systemically with scaling and root planing (SRP) to the treatment of experimental periodontitis (EP) in rats treated with 5-fluorouracil.

Methods: A cotton ligature was installed on the molars of rats. The animals (n = 54) underwent chemotherapy and were divided into groups: SRP (n = 18), scaling and root planing only; LP (n = 18), SRP and 4 sessions of local probiotic (PRO); SP, SRP and 4 sessions of systemic PRO. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104825DOI Listing

MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2.

Arch Oral Biol 2020 Jun 17;117:104818. Epub 2020 Jun 17.

Department of Stomatology, Tianjin Union Medical Center, Tianjin, 300121, People's Republic of China. Electronic address:

Background: MiRNAs have been demonstrated to be important regulators during osteogenic differentiation in multiple types of stem cells. In the study, the interaction between miR-375 and TOB2 was analyzed to identify their functions on the proliferation and osteogenic differentiation of hPDLSCs.

Methods: hPDLSCs were isolated from human first premolars, and hPDLSCs stably expressing and silenced miR-375 were constructed using miR-375-ago and miR-375-antago, respectively. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104818DOI Listing

Botulinum toxin A alleviates orofacial nociception induced by orthodontic tooth movement through nociceptin/orphanin-FQ pathway in rats.

Arch Oral Biol 2020 Jun 12;117:104817. Epub 2020 Jun 12.

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objectives: To investigate the effect and mechanism of botulinum neurotoxin type A (BoNT/A) in the modulation of orofacial nociception induced by orthodontic tooth movement in rats.

Methods: An orofacial nociception model was established in male Sprague-Dawley rats by ligating closed-coil springs between incisors and ipsilateral molars. There were two group sets of animals. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104817DOI Listing

Natural products for orofacial nociception in pre-clinical studies: A systematic review.

Arch Oral Biol 2020 May 11;117:104748. Epub 2020 May 11.

Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Programme in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address:

Objective: The aim of this systematic review was to summarize the use of natural products (NP) in the treatment of orofacial nociception in animal models.

Methods: Pre-clinical studies that have evaluated the efficacy of NPs in experimental orofacial nociception were sought in the Medline, Web of Science, Scopus, Embase, SciELO, LILACS and Scholar databases in January 2020, covering the period since the inception of each one. Two reviewers independently selected the studies, extracted the data and evaluated the risk of bias of the included studies. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104748DOI Listing

Low-intensity pulsed ultrasound activates autophagy in periodontal ligament cells in the presence or absence of lipopolysaccharide.

Arch Oral Biol 2020 May 20;117:104769. Epub 2020 May 20.

College of Stomatology, Chongqing Medical University, PR China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engisneering of Higher Education, PR China. Electronic address:

Objective: This study aims to determine if low-intensity pulsed ultrasound (LIPUS) activates autophagy in human periodontal ligament cells (PDLCs) irrespective of lipopolysaccharide.

Design: Six groups were designed: control, LIPUS, lipopolysaccharide, LIPUS + lipopolysaccharide, LIPUS+3-Methyladenine, LIPUS + lipopolysaccharide+3-Methyl- adenine. LIPUS pretreated PDLCs for 2 h and lipopolysaccharide treated for different times. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104769DOI Listing
May 2020
1.880 Impact Factor

Cystathionine γ-lyase-HS facilitates mandibular defect healing via inducing osteogenic differentiation of bone marrow mesenchymal stem cells.

Arch Oral Biol 2020 Jun 17;117:104821. Epub 2020 Jun 17.

Department of Orthodontics, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 399 Middle Yanchang Road, Shanghai, 200072, China. Electronic address:

Objective: To investigate the effects of endogenous hydrogen sulfide (HS) synthase, cystathionine-γ-lyase (CSE), on the healing of mandibular defect and the osteogenic differentiation of human mandibular bone marrow mesenchymal stem cells (HM-BMMSCs).

Methods: Sixty 8-week male C57BL/6 wild-type (WT) mice and CSE knockout (CSE) mice were divided into WT group, CSE group and CSE + GYY4137 (a slow-releasing HS donor) group. Mandibular defect healing in each group was identified by micro-CT. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104821DOI Listing

The effects of taxifolin on alveolar bone in experimental periodontitis in rats.

Arch Oral Biol 2020 Jun 22;117:104823. Epub 2020 Jun 22.

Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

Objective: This study aimed to evaluate the effect of taxifolin, a powerful antioxidant, on the progression of periodontitis by immunohistochemical and cone-beam computed tomography (CBCT) examination.

Design: This study was performed with 32 rats in four experimental groups: a non-ligated group (Control, n = 8), periodontitis group (Perio, n = 8), periodontitis with 1 mg/kg/day taxifolin group (Taxi-1, n = 8), and periodontitis with 10 mg/kg/day taxifolin group (Taxi-10, n = 8). A ligature-induced experimental periodontitis design was used. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104823DOI Listing

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.

Arch Oral Biol 2020 Jun 20;117:104819. Epub 2020 Jun 20.

Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

Objective: The objective of this study was to evaluate the ability of three distinct agents on the induction of senescence in human dental pulp stem cells (DPSCs).

Design: DPSCs from three separate donors were treated with HO, doxorubicin and ultraviolet (UV) irradiation. The response of the cells to the three agents was assayed by specific staining for SA-βGal, RT-qPCR and flow cytometry. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104819DOI Listing

Estrogen protects dental roots from orthodontic-induced inflammatory resorption.

Arch Oral Biol 2020 Jun 18;117:104820. Epub 2020 Jun 18.

Department of Restorative Destistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Objective: Root resorption is a side effect of orthodontic tooth movement (OTM). Despite the recognized role of estrogen on bone, there is little information about their effects on orthodontic-induced inflammatory root resorption (OIIRR). We aimed to investigate if estrogen deficiency affects OIIRR in two mice strains. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104820DOI Listing

Antimicrobial and protective effects of non-thermal plasma treatments on the performance of a resinous liner.

Arch Oral Biol 2020 Jun 20;117:104822. Epub 2020 Jun 20.

Department of Prosthodontics and Periodontology, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil. Electronic address:

Objective: Overcoming substantial shortcomings of soft liners as physico-chemical changes and liner-biofilm-related infections remains a challenge in the rehabilitation treatment. In this study, protective non-thermal plasma (NTP) treatments were developed on the soft liner surface to improve its surface and physico-chemical properties and to reduce fungal colonization after biofilm inhibition challenge.

Methods: Resinous liner specimens (Coe-Soft) were prepared and distributed in 3 groups according to the surface treatments: (1) untreated (control); (2) treated with sulfur hexafluoride-based NTP (SF); and (3) treated with hexamethyldisiloxane-based NTP (HMDSO). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104822DOI Listing

Oral biofilm uptake of mineral ions released from experimental toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler.

Arch Oral Biol 2020 May 27;117:104777. Epub 2020 May 27.

Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.

Objective: To clarify the fluoride/mineral kinetics in an oral biofilm following concurrent application of fluoride and other mineral ions released from experimental toothpaste containing S-PRG filler using depth-specific analysis.

Study Design: Twenty subjects wore in situ plaque-generating devices, comprised of a pair of enamel slabs, and a biofilm was allowed to form. The devices were removed after three days, immersed in the toothpaste filtrate containing Al, B, Sr and F ions for 1 min, and then reinserted at the same location. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104777DOI Listing

Physicochemical properties of dentinogenesis imperfecta with a known DSPP mutation.

Arch Oral Biol 2020 Jun 13;117:104815. Epub 2020 Jun 13.

Department of Pediatric Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Republic of Korea. Electronic address:

Aim: To investigate the chemical and mechanical properties of teeth affected by a 1-bp deletion (c.2688delT) in the DSPP gene.

Methods And Materials: Maxillary first premolars were extracted from the affected individual at age 9 years due to the orthodontic reason for crowding. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104815DOI Listing

Glucose effect on Candida albicans biofilm during tissue invasion.

Arch Oral Biol 2020 Apr 30;117:104728. Epub 2020 Apr 30.

Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Objective: To evaluate, in vitro, the effect of two glucose concentrations (0.1 mM and 1.0 mM, simulating glucose concentration in saliva of healthy and diabetic individuals) on Candida albicans biofilm grown on epithelial monolayer. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104728DOI Listing

Long noncoding RNA TUG1 promotes osteogenic differentiation of human periodontal ligament stem cell through sponging microRNA-222-3p to negatively regulate Smad2/7.

Arch Oral Biol 2020 Jun 8;117:104814. Epub 2020 Jun 8.

Department of Cariology and Endodontology, Qingdao Stomatological Hospital, Qingdao, Shandong 266001, China. Electronic address:

Objective: To scrutinize the function of long non-coding RNA TUG1 on the osteogenic differentiation of human periodontal ligament stem cells in periodontitis and its specific mechanism.

Methods: Human periodontal ligament stem cells were extracted from human periodontium, followed by induction of osteogenic differentiation with osteogenic medium. Knockdown or overexpression of TUG1, microRNA-222-3p or Smad2/7 were performed in human periodontal ligament stem cells to observe their effect on expressions of osteogenic differentiation markers (Runx2, ALP, and OCN), and on calcium nodule formation by Alizarin red staining. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104814DOI Listing

A semi-synthetic flavonoid from Bauhinia pulchella stem attenuates inflammatory osteolysis in periodontitis in rats: Impact on cytokine levels, oxidative stress, and RANK/RANKL/OPG pathway.

Arch Oral Biol 2020 Jun 10;117:104816. Epub 2020 Jun 10.

School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Objectives: Many species of theBauhinia genus have been widely used in folk medicine as analgesic, anti-inflammatory and antioxidant agents. (-)-Fisetinidol palmitate is a semi-syntetic flavonoid obtained from the ethanolic extract of the stem of Bauhinia pulchella. This study aimed to evaluate the antiresorptive effect of the semi-syntetic (-)-fisetinidol palmitate in ligature-induced periodontitis in rats. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104816DOI Listing
June 2020
1.880 Impact Factor

Associations of the microRNA gene polymorphisms with the risk of non-syndromic supernumerary teeth in a Chinese population.

Arch Oral Biol 2020 May 20;117:104771. Epub 2020 May 20.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Objective: Non-syndromic supernumerary teeth (NSST) are a common type of dental anomaly. microRNAs (miRNAs) play an important role in craniofacial and tooth development. Therefore, we hypothesized that single nucleotide polymorphisms (SNPs) of miRNAs may be associated with the susceptibility of NSST. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104771DOI Listing

Micro-computed tomographic analysis of the mesial root of mandibular first molars with bifid apex.

Arch Oral Biol 2020 Jun 8;117:104792. Epub 2020 Jun 8.

Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil.

Objectives: The aim of the present study was to evaluate the influence of bifid and non-bifid configurations of the mesial root of mandibular first molars in the canal anatomy using micro-computed tomography (micro-CT).

Design: Thirty mesial roots with bifid apex were pair-matched with 30 non-bifid roots by means of micro-CT. Bifid and non-bifid mesial roots were compared regarding morphological aspects at the apical third, dentin thickness, and the presence of isthmus and middle mesial canal (MMC). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104792DOI Listing

Long-term evaluation of alendronate treatment on the healing of calvaria bone defects in rats. Biochemical, histological and immunohistochemical analyses.

Arch Oral Biol 2020 Jun 2;117:104779. Epub 2020 Jun 2.

Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara Sao Paulo, Brazil; Advanced Research Center in Medicine, Union of the Colleges of the Great Lakes (UNILAGO), São José do Rio Preto, S.P., Brazil.

Objective: The aim of this study was to investigate the effects of the long-term alendronate administration on bone healing in defects created in rat calvarias.

Materials And Methods: Female Wistar rats were randomly distributed into 2 groups: Control (CTL): animals received saline solution once a week; and Alendronate (ALD): rats underwent alendronate treatment (1 mg/kg/weekly). After 120 days from the commencement of treatment, a critical size defect was created in all animals, and 10 animals from each group were sacrificed at 5, 10, 15, 20, 25, 30, 45 and 60-days after the defect creation. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104779DOI Listing

Expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in human dental pulp tissues and cells.

Arch Oral Biol 2020 Jun 8;117:104794. Epub 2020 Jun 8.

Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, Guangdong, China. Electronic address:

Objective: This study aims to investigate the expression pattern of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6) in human dental pulp tissues and cells, and roughly explore the role of NLRP6 in dental pulp immunity.

Methods: Immunohistochemistry and immunofluorescence double staining were performed to determine the expression and localization of NLRP6 in healthy and inflamed pulp tissues. The expression of NLRP6 in human dental pulp cells (HDPCs) was investigated by immunocytofluorescence. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104794DOI Listing

Quantification of pathogenic bacteria in the subgingival oral biofilm samples collected from cigarette-smokers, individuals using electronic nicotine delivery systems and non-smokers with and without periodontitis.

Arch Oral Biol 2020 Jun 6;117:104793. Epub 2020 Jun 6.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Objective: The aim of the present study was to quantify pathogenic bacteria isolated from the subgingival oral-biofilm samples collected from cigarette-smokers and ENDS-users with periodontitis, when compared to non-smokers with and without periodontitis.

Methods: Demographic data was collected using a questionnaire. Periodontal parameters (plaque [PI] and gingival [GI] indices, clinical attachment loss [CAL], probing depth [PD] and marginal bone loss [MBL]) were measured. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104793DOI Listing

TNF-α stimulates the expression of RANK during orthodontic tooth movement.

Arch Oral Biol 2020 Jun 5;117:104796. Epub 2020 Jun 5.

Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Objective: This study aimed to evaluate the effects of tumor necrosis factor (TNF)-α on receptor activator of nuclear factor-κB (RANK) expression in osteoclast precursors in vitro and during orthodontic tooth movement (OTM) in vivo.

Design: We assessed whether TNF-α influenced RANK expression levels in osteoclast precursors in vitro by real-time PCR and western blotting. For in vivo experiments, TNF-α was subcutaneously injected into mouse calvariae daily for 5 days. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104796DOI Listing

In vivo and in vitro study of enamel fluid flow in human premolars.

Arch Oral Biol 2020 Jun 6;117:104795. Epub 2020 Jun 6.

Department of Stomatology, Faculty of Dentistry, Srinakharinwirot University, Bangkok 10110, Thailand. Electronic address:

Objective: To investigate fluid flow through enamel in intact human premolars in vivo and in vitro by using the replica technique.

Design: The experiments were done on 17 premolars of 10 subjects (aged 10-25 yrs) to be extracted during orthodontic treatment. Teeth were divided into 2 groups. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104795DOI Listing

Keratin expression in gingival tissue and primary cultured gingival keratinocytes: Are there differences?

Arch Oral Biol 2020 Jun 2;117:104780. Epub 2020 Jun 2.

Pathology Department, School of Dentistry, University of São Paulo, Brazil. Electronic address:

Objective: To investigate whether the process of primary gingival keratinocytes culture obtained from normal human gingiva modifies the expression of keratins (K) 10, K14, and K19.

Design: Human gingival fragments were collected from healthy individuals in the same oral site. One part of the samples underwent an immunohistochemistry assay for K10, K14, and K19. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104780DOI Listing

Effect of Low- Level Laser Therapy on Bone Regeneration of Critical-Size Bone Defects: A Systematic Review of In Vivo Studies and Meta-Analysis.

Arch Oral Biol 2020 May 28;117:104782. Epub 2020 May 28.

Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Low-level laser therapy is a method for osteogenesis since it stimulates cell proliferation, vascularization and osteoblastic activity. Various protocols applying low-level laser with different outcomes exist. The aim of the present study was to review the result of different methods on bone formation in critical-size defects of in vivo studies. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104782DOI Listing

Mandibular molar C-shaped root canals in 5th millennium BC China.

Arch Oral Biol 2020 May 25;117:104773. Epub 2020 May 25.

Department of Endodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Province, PR China. Electronic address:

Objective: The aim of this study was to analyze the occurrence and variations in C-shaped canals in ancient Chinese teeth and compare the differences of these features between ancient and age-matched modern populations.

Design: Approximately 5000-year-old craniofacial bone remains were collected from the fossils of 38 individuals (total: 68 mandibular second molars) excavated from the Jiaojia site. The control group comprised of an equal number of randomly selected modern samples. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104773DOI Listing

Hematogenous apoptotic mechanism in salivary glands in chronic periodontitis.

Arch Oral Biol 2020 May 21;117:104775. Epub 2020 May 21.

Division of Physiology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakitaku, Kitakyushu, Fukuoka, 803-8580, Japan. Electronic address:

Objective: The aim of the study is to investigate the apoptotic mechanism in salivary glands in the rat experimental periodontitis model.

Design: A rat periodontitis model was prepared by using a ligature around the second upper molar. In the salivary (parotid and submandibular) glands and blood samples, putative apoptotic factors and pathway molecules were investigated in vivo and in vitro. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104775DOI Listing

A systematic review of the microbiota composition in various peri-implant conditions: data from 16S rRNA gene sequencing.

Arch Oral Biol 2020 May 27;117:104776. Epub 2020 May 27.

Department of Conservative Dentistry, Periodontics Unit, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Objective: To systematically review the literature regarding the microbiota composition in various peri-implant conditions as analyzed by 16S rRNA gene sequencing methods.

Methods: Electronic searches were conducted at MEDLINE/PubMed, Scopus, Embase, ScienceDirect and Web of Science databases looking for articles published up to April 2020. Observational prospective investigations were considered with systemically healthy patients and that had presented the description of the microbiota composition of peri-implantitis (PI), peri-implant mucositis (PM) and/or health implants (HI) by using 16S rRNA gene sequencing analysis were considered eligible. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104776DOI Listing
May 2020
1.880 Impact Factor

Effects of radiopaque double antibiotic pastes on the proliferation, alkaline phosphatase activity and mineral deposition of dental pulp stem cells.

Arch Oral Biol 2020 May 13;117:104764. Epub 2020 May 13.

Department of Biomedical Sciences & Comprehensive Care, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA. Electronic address:

Objective: The aim of this study was to investigate the effects of two radiopaque agents, barium sulfate (BaSO) or zirconium oxide (ZrO) in double antibiotic paste (DAP), on the proliferation and mineral deposition of human dental pulp stem cells (DPSC).

Materials And Methods: Radiopaque antimicrobial medicaments composed of methylcellulose (MC) thickening polymer with BaSO or ZrO and either 1 or 5 mg/mL DAP (equal portions of metronidazole and ciprofloxacin) were used to investigate DPSC proliferation after 3 days, and alkaline phosphatase (ALP) activity and mineral deposition after 7 and 14 days. Radiopaque agents without DAP and Ca(OH) were used as controls. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104764DOI Listing

Effects of orthodontic tooth extrusion produced by different techniques, on the periodontal tissues: a histological study in dogs.

Arch Oral Biol 2020 Aug 20;116:104768. Epub 2020 May 20.

Department of Diagnostic and Surgery, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil.

Objective: The aim of this study was to compare the periodontal tissue changes resulting from different methods of orthodontic tooth extrusion in dogs.

Materials And Methods: Notches were surgically prepared in the root surface at the bone crest level of the first premolars of mongrel dogs. After 37 days, extrusion of the first lower and upper premolars was randomly performed by 3 different methods: conventional orthodontic extrusion (OE); open flap debridement performed immediately before orthodontic extrusion (OF); and orthodontic extrusion associated with weekly fiberotomy and scaling (FS). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104768DOI Listing

Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis.

Arch Oral Biol 2020 Aug 16;116:104763. Epub 2020 May 16.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 3rd Section S Renmin Road, 14#, Chengdu, PR China; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, PR China. Electronic address:

Objectives: To investigate the underlying mechanism between diabetic periodontitis and NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis.

Design: Experimental models of diabetes-associated periodontitis were implemented in db/db mice. We detected NLRP3 inflammasome related cytokines and gasdermin D (GSDMD) both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104763DOI Listing
August 2020
1.880 Impact Factor

Oral prevalence and antifungal susceptibility of Candida species in cystic fibrosis patients.

Arch Oral Biol 2020 Aug 22;116:104772. Epub 2020 May 22.

Institute of Science and Technology, São Paulo State University/UNESP, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, 12245-000, Brazil. Electronic address:

Objective: This study aimed at assessing the oral prevalence ofCandida species in cystic fibrosis patients and the antifungal susceptibility of the isolates.

Design: One hundred patients aged 3-20 years old were included in the study and were divided into three groups: G1 (low severity disease): 25 cystic fibrosis patients with Shwachman-Kulczycki score (SK) between 100 and 71; G2 (high severity disease): 25 cystic fibrosis patients with SK score under 40; and G3 (control): 50 healthy patients age- and gender-matched to cystic fibrosis patients. Stimulated saliva samples were collected and the oral fungal concentrations were assessed. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104772DOI Listing

Rhodiola rosea extract inhibits the biofilm formation and the expression of virulence genes of cariogenic oral pathogen Streptococcus mutans.

Arch Oral Biol 2020 Aug 19;116:104762. Epub 2020 May 19.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China. Electronic address:

Objective: The present study aimed to evaluate the effect of Rhodiola rosea extract (RE) on Streptococcus mutans biofilm formation and the relevant mechanism of its action.

Methods: The effect of RE on the biofilm formation and extracellular polysaccharides (EPS) synthesis of S. mutans was assessed by confocal laser scanning microscopy (CLSM), crystal violet staining and CFU counting method. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104762DOI Listing

The rostral ventromedial medulla orexin 1 receptors and extracellular signal-regulated kinase in hippocampus are involved in modulation of anxiety behavior induced by dental pulp nociception in adult male rats.

Arch Oral Biol 2020 Aug 25;116:104778. Epub 2020 May 25.

Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran; Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Objectives: To explore the role of rostral ventromedial medulla (RVM) orexin 1 receptors (OX1R) on orofacial nociception -induced anxiety and locomotion in rats.

Design: Forty two adult male Wistar rats (220-270 gr) were randomly divided into 7 groups (n = 6) as follows: untreated control, capsaicin, capsaicin vehicle-treated group (sham operation), capsaicin groups pretreated by intra-RVM administration orexin 1 receptor (OX1R) agonist (orexin A) or antagonist (SB-334867) and the capsaicin groups treated by drugs vehicles (DMSO or aCSF). Orofacial nociception was induced by intradental application of capsaicin (100 μg) into the incisors of rats. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104778DOI Listing

Baicalin inhibits root resorption during tooth movement in a rodent model.

Arch Oral Biol 2020 Aug 19;116:104770. Epub 2020 May 19.

Department of Orthodontics and Craniofacial Development Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan.

Objective: Baicalin mediates bone metabolism and has shown protective activity against periodontal tissue damage in a rat model of periodontitis. Therefore, we hypothesized that baicalin may inhibit the root resorption that occurs during orthodontic tooth movement and examined its effect on the histological changes in periodontal tissue that occur during tooth movement.

Methods: First molars of rats were subjected to traction using excessive orthodontic force to produce a root resorption model. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104770DOI Listing

Porphyromonas gingivalis lipopolysaccharide and glycated serum albumin increase the production of several pro-inflammatory molecules in human gingival fibroblasts via NFκB.

Arch Oral Biol 2020 Aug 20;116:104766. Epub 2020 May 20.

Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Objective: Diabetes increases the incidence/severity of periodontal diseases by inducing a chronic inflammation, driven by accumulation of AGEs (advanced glycation end products). We tested whether glycated human serum albumin (G-HSA, a form of AGE), representing a diabetic state, augments the pro-inflammatory response of human gingival fibroblasts (hGFs) to a bacterial challenge (Porphyromonas gingivalis Lipopolysaccharide (LPS)).

Methods: Primary hGFs were incubated with LPS (0. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104766DOI Listing

Effect of vitamin C and E on oxidative stress and antioxidant system in the salivary glands of STZ-induced diabetic rats.

Arch Oral Biol 2020 Aug 16;116:104765. Epub 2020 May 16.

Department of Biomaterials and Oral Biology, Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, Brazil. Electronic address:

Objective: We examined the effects of vitamin C and E supplementation in the prevention of oxidative stress in the salivary glands of STZ-induced diabetic rats.

Design: Forty-eight male Wistar rats were divided into six groups (n = 8 in each): control (C), control supplemented with vitamin C (Cvc) and E (Cve), diabetic (D), and diabetic supplemented with vitamin C (Dvc) and E (Dve). Vitamin C (150 mg/kg) and E (300 mg/kg) were daily administered for 21 days. Read More

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Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro.

Arch Oral Biol 2020 Aug 20;116:104774. Epub 2020 May 20.

Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, 49 Busandaehak-Ro, Yangsan 626-870, South Korea; Periodontal Disease Signaling Network Research Center, Dental & Life Science Institute, Pusan National University, 49 Busandaehak-Ro, Yangsan 626-870, South Korea. Electronic address:

Objectives: The aim of the present study was to identify the anticancer effects and the mechanisms of action of shikonin and its analogue isobutyrylshikonin in oral squamous carcinoma cells.

Designs: The cytotoxic effects of isobutyrylshikonin and shikonin in Ca9-22 and SCC-25 cells were analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry analysis of Annexin V/Propidium Iodide (PI) staining, western blot analysis and immunohistochemistry.

Results: Treatment with both isobutyrylshikonin and shikonin induced dose- and time-dependent apoptotic cell death in Ca9-22 cells, although the IC of isobutyrylshikonin was less than that of shikonin. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104774DOI Listing
August 2020
1.880 Impact Factor

Human Papillomavirus E6/E7 mRNA detection by in situ hybridization in oral cavity squamous cell carcinoma.

Arch Oral Biol 2020 Aug 7;116:104746. Epub 2020 May 7.

Programa de Pós-Graduação em Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Espirito Santo, Vitoria, Espirito Santo, Brazil. Electronic address:

Objective: The aim of this study was to evaluate the application of in situ hybridization using E6/E7 mRNA probes to identify the frequency of high-risk HPV transcriptionally active and the use of HPV status as a prognostic biomarker in oral cavity squamous cell carcinoma (OCSCC).

Methods: Ninety-nine OCSCC samples were evaluated from Hospital Santa Rita de Cassia, Hospital Universitário Cassiano Antônio de Moraes and University Hospitals Coventry and Warwickshire NHS Trust. After tissue microarray construction, the slides were submitted to an in situ hybridization detection method for HPV E6/E7 mRNA. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104746DOI Listing

Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.

Arch Oral Biol 2020 Aug 19;116:104767. Epub 2020 May 19.

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India. Electronic address:

Objective: The aim of this study was to determine the association of EGLN1 gene variant SNP rs479200 (T > C) with the risk of oral cancer.

Materials And Methods: A case-control study was conducted by involving 103 oral cancer patients and 206 age and gender-matched healthy controls. SNP rs479200 was genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104767DOI Listing

Antimicrobial activities of natural plant compounds against endodontic pathogens and biocompatibility with human gingival fibroblasts.

Arch Oral Biol 2020 Aug 18;116:104734. Epub 2020 May 18.

Oral Ecology Research Group, Faculty of Dentistry, Université Laval, Quebec City, QC, Canada. Electronic address:

Objectives: The aim of the present study was to investigate three licorice-derived polyphenols (glabridin, licochalcone A, licoricidin) as well as cinnamon oil for their antimicrobial activities against major endodontic pathogens: Enterococcus faecalis, Streptococcus mutans, Actinomyces israelii, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas endodontalis, and Candida albicans. The synergistic interactions between the four compounds and chlorhexidine were assessed on E. faecalis. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104734DOI Listing

Nutritional status and masticatory function of the indigenous compared with non-indigenous people of Nayarit, Mexico.

Arch Oral Biol 2020 Jul 19;115:104731. Epub 2020 Apr 19.

School of Dentistry, Faculty of Medicine and Health Sciences, University of Barcelona, Catalonia, Spain; Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. Electronic address:

Objective: The objective of this study was to compare the nutritional statuses and masticatory function of the non-indigenous and indigenous adult people of the state of Nayarit, Mexico.

Design: Forty-two indigenous (Cora or Huichol ethnic group) and 100 non-indigenous people, all adults with natural dentition, participated in this cross-sectional study. They performed a free-style masticatory test consisting five trials of chewing silicon pieces for 20 cycles. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104731DOI Listing

Oral health in patients with Marfan syndrome.

Arch Oral Biol 2020 Aug 16;116:104745. Epub 2020 May 16.

Department of Biomedical and Dental Sciences, Morphological and Functional Images, School of Dentistry, University of Messina, ME, Italy. Electronic address:

Introduction: The role of this study is to highlight a correlation between patients with Marfan syndrome and oral health status by evaluating and reviewing the relevant scientific literature. The syndrome is characterized by an abnormal production of the fibrillin1 protein. The manifestations of Marfan syndrome affect organs that contain connective tissue such as the skeletal system, the eyes, the heart and the blood vessels, the lungs and the fibrous membranes that cover the brain and the spine. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104745DOI Listing

Salivary lubricity (ex vivo) enhances upon moderate exercise: A pilot study.

Arch Oral Biol 2020 Aug 7;116:104743. Epub 2020 May 7.

Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, Faculty of Environment, University of Leeds, Leeds, LS2 9JT, UK. Electronic address:

Objective: This study sought to examine the effects of moderate intensity exercise on lubrication performance of saliva. We hypothesized that exercise would result in enhanced salivary lubricity by direct sympathetic stimulation of the salivary proteins.

Study Design: In total, 11 healthy young pre-menopausal female participants (mean age: 24. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322397PMC

Influence of Demographic Factors on the Prevalence of a Second Root Canal in Mandibular Anterior Teeth - A Systematic Review and Meta-Analysis of Cross-Sectional Studies Using Cone Beam Computed Tomography.

Arch Oral Biol 2020 Aug 11;116:104749. Epub 2020 May 11.

Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil.

Objective: The purpose of this systematic review was to assess the influence of population demographic characteristics on the prevalence of a second canal in mandibular anterior teeth.

Design: Four electronic databases and five peer-reviewed journals were searched from May 2018 to September 2019 for prevalence studies using cone-beam computed tomographic imaging on second canal morphology in mandibular anterior teeth. The identified studies were subjected to a hand search of bibliographic references followed by contact with the authors. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104749DOI Listing
August 2020
1.880 Impact Factor

MicroRNA-345 functions as a tumor suppressor via targeting ZEB2 in oral squamous cell carcinoma.

Arch Oral Biol 2020 Aug 24;116:104732. Epub 2020 Apr 24.

Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China. Electronic address:

Objective: The objective of this study was to explore the role of miRNAs in OSCC and to identify potential novel biomarkers or therapeutic agents in OSCC treatment.

Design: Microarray analysis and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were performed to identify and verify differentially expressed miRNAs in OSCC tissues. The migration, invasion, proliferation and cell cycle of OSCC cells were analyzed to determine the function of miR-345 in OSCC development. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104732DOI Listing
August 2020
1.880 Impact Factor

Comparison of RANKL and osteoprotegerin levels in the gingival crevicular fluid of young cigarette- and waterpipe-smokers and individuals using electronic nicotine delivery systems.

Arch Oral Biol 2020 Jul 11;115:104714. Epub 2020 Apr 11.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia. Electronic address:

Objective: The aim of the present observational case-control study was to compare the levels of Receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) of cigarette- and waterpipe-smokers and electronic-nicotine-delivery-systems (ENDS)-users.

Methods: Demographic data was collected using a questionnaire. Clinical periodontal parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD] and clinical attachment loss [CAL]) were measured; and GCF samples were collected from the deepest periodontal pocket of the mandibular right first molar. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104714DOI Listing
July 2020
1.880 Impact Factor