4,017 results match your criteria Archives of Disease in Childhood-Fetal and Neonatal Edition[Journal]


What's New in the Management of Neonatal Early-Onset Sepsis?

Arch Dis Child Fetal Neonatal Ed 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise. Read More

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Clinical outcomes of preterm infants while using automated controllers during standard care: comparison of cohorts with different automated titration strategies.

Arch Dis Child Fetal Neonatal Ed 2022 May 16. Epub 2022 May 16.

Neonatology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To compare short-term clinical outcome after using two different automated oxygen controllers (OxyGenie and CLiO).

Design: Propensity score-matched retrospective observational study.

Setting: Tertiary-level neonatal unit in the Netherlands. Read More

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Comparison of regional versus global growth charts for the classification of small-for-gestational age neonates.

Arch Dis Child Fetal Neonatal Ed 2022 May 12. Epub 2022 May 12.

Pediatrics, All India Institute of Medical Sciences, New Delhi, Delhi, India

Objective: To compare the performance of regional versus global charts for identifying small-for-gestational age (SGA) neonates with short-term adverse outcomes.

Design: Prospective cohort study.

Setting: Level-3 neonatal unit in India. Read More

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Vestibular and balance dysfunction in children with congenital CMV: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2022 May 11. Epub 2022 May 11.

Academic Paediatrics, Royal Alexandra Children's Hospital, Brighton, UK.

Objective: This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.

Design: MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.

Patients: Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture). Read More

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Effects of the SARS-CoV-2 pandemic on perinatal activity in Yorkshire and the Humber region during 2020: an interrupted time series analysis.

Arch Dis Child Fetal Neonatal Ed 2022 May 11. Epub 2022 May 11.

Embrace Transport Service, Sheffield Childrens' Hospital NHS Foundation Trust, Barnsley, UK.

Objective: To assess the impact of public health measures taken during the COVID-19 pandemic on perinatal health indicators.

Design: Interrupted time series analysis comparing periods of the pandemic with the previous 5 years.

Setting: Yorkshire and the Humber region, England (2015-2020). Read More

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Short-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial.

Arch Dis Child Fetal Neonatal Ed 2022 May 9. Epub 2022 May 9.

Neonatology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands

Objective: Observational studies in preterm infants suggest that systemic hydrocortisone improves pulmonary condition but may also lead to systemic adverse effects. We report the short-term pulmonary and systemic effects of hydrocortisone initiated in the second week.

Design: Randomised placebo-controlled trial. Read More

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Effect of antibiotics in the first week of life on faecal microbiota development.

Arch Dis Child Fetal Neonatal Ed 2022 May 9. Epub 2022 May 9.

Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands

Background: Infants are frequently exposed to antibiotics (AB) in the first week of life for suspected bacterial infections. Little is known about the effect of AB on the developing intestinal microbiota. Therefore, we studied intestinal microbiota development with and without AB exposure in the first week of life in term born infants. Read More

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Parental presence during neonatal transfers conducted by a national transport service.

Arch Dis Child Fetal Neonatal Ed 2022 May 9. Epub 2022 May 9.

ScotSTAR Scottish Neonatal Transport Service, Glasgow, UK.

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Comparison of neonatal morbidity and mortality between single-room and open-bay care: a retrospective cohort study.

Arch Dis Child Fetal Neonatal Ed 2022 Apr 20. Epub 2022 Apr 20.

Division of Neonatology, Department of Pediatrics, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Objective: In response to the increasing focus on family-centred care, neonatal intensive care unit (NICU) environments have gradually shifted towards the single-room design. However, the assumed benefits of this emerging design remain a subject of debate. Our goal was to evaluate the impact of single-room versus open-bay care on the risk of neonatal morbidity and mortality in preterm neonates. Read More

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Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Arch Dis Child Fetal Neonatal Ed 2022 Apr 15. Epub 2022 Apr 15.

Centre for Perinatal Research (CePR), University of Nottingham School of Medicine, Nottingham, UK

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.

Design: Population-based observational study. Read More

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Trends in the use of non-invasive respiratory support for term infants in tertiary neonatal units in Australia and New Zealand.

Arch Dis Child Fetal Neonatal Ed 2022 Apr 11. Epub 2022 Apr 11.

Australian Institute of Health Innovation, Macquarie University Faculty of Medicine and Health Sciences, Sydney, New South Wales, Australia.

Objective: To determine whether the use of non-invasive respiratory support, such as continuous positive airway pressure and nasal high flow, to treat term infants in Australian and New Zealand tertiary neonatal intensive care units (NICUs) has changed over time, and if so, whether there are parallel changes in short-term respiratory morbidities.

Design: Retrospective database review of patient-level data from the Australian and New Zealand Neonatal Network (ANZNN) from 2010 to 2018. Denominator data on the number of term inborn livebirths in each facility was only available as annual totals. Read More

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SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.

Arch Dis Child Fetal Neonatal Ed 2022 Apr 8. Epub 2022 Apr 8.

School of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia

Objective: To conduct a meta-analysis to determine the association between prenatal drug exposure and risk of sudden infant death syndrome (SIDS).

Design: Studies were searched using PubMed, Medline and Embase and restricted to English, with no publication date limit. Selected studies included published cohort, population or case studies comparing the incidence of SIDS among drug-exposed with drug-free controls. Read More

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Gastric outlet obstruction with prostaglandin E1 infusion in congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2022 Apr 6. Epub 2022 Apr 6.

Department of Neonatal Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.

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Necrotising enterocolitis, focal intestinal perforation or something else: how best to proceed.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 31. Epub 2022 Mar 31.

Neonatal Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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Preterm birth and infant diurnal cortisol regulation.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 14. Epub 2022 Mar 14.

School of Nursing and Midwifery, Edith Cowan University, Joondalup, Western Australia, Australia.

Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy.

Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Read More

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Dexmedetomidine affects cerebral activity in preterm infants.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 14. Epub 2022 Mar 14.

Division of Neonatology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Madrid, Spain.

The use of dexmedetomidine (DEX) has been extended in preterm newborns, but the effects on cerebral activity and their relationship with haemodynamic changes has not been studied.We retrospectively studied the effects of DEX administered to 10 preterm newborns, assessing amplitude-integrated EEG (aEEG) parameters, brain regional SO (brSO), heart rate, non-invasive mean blood pressure (MBP), transcutaneous oxygen saturation (SpO), venous pCO2 and haemoglobin (Hb) values, in two 6-hour periods: one starting 6 hours before the beginning of DEX perfusion and the other 6 hours afterwards.DEX infusion led to brSO decrease not associated to heart rate, MBP, SpO, Hb or pCO2 variation, which suggests that brSO decrease could be related to local vasoconstriction. Read More

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Time to positivity of blood cultures in neonatal late-onset bacteraemia.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 10. Epub 2022 Mar 10.

Division of Research, Kaiser Permanente Northern California, San Francisco, California, USA.

Objective: To determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours.

Design: Retrospective cohort study.

Setting: 16 birth centres in two healthcare systems. Read More

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Saliva cortisol diurnal variation and stress responses in term and preterm infants.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 7. Epub 2022 Mar 7.

MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, UK

Objective: To determine if preterm birth is associated with adaptation of the hypothalamic-pituitary-adrenal (HPA) axis and whether HPA axis programming relates to the degree of prematurity (defined as extremely preterm birth at <28 weeks or very preterm birth at 28-32 weeks gestation).

Design: This study reports findings from a prospective birth cohort. Saliva cortisol concentrations were measured prevaccination and postvaccination, and in the morning and evening, at 4 months chronological age. Read More

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Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 2. Epub 2022 Mar 2.

Department of Neonatology, Máxima Medical Center, Veldhoven, The Netherlands.

Objective: In 2010, the Dutch practice regarding initiation of active treatment in extremely preterm infants was lowered from 25 completed weeks' to 24 completed weeks' gestation. The nationwide Extremely Preterm Infants - Dutch Analysis on Follow-up Study was set up to provide up-to-date data on neurodevelopmental outcome at 2 years' corrected age (CA) after this guideline change. National cohort study. Read More

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Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma: a retrospective multicentre cohort study.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 1. Epub 2022 Mar 1.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden.

Objective: To determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids.

Design And Patients: Retrospective multicentre cohort study in 19 infants born at gestational age <29 weeks requiring plasma transfusion during their first week of life.

Setting: Three neonatal intensive care units in Sweden. Read More

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Optimising growth in very preterm infants: reviewing the evidence.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 28. Epub 2022 Feb 28.

Department of Neonatal Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Infants born before 32 weeks' postmenstrual age are at a high risk of growth failure. International guidelines have long recommended that they match the growth of an equivalent fetus, despite the challenges posed by ex utero life and comorbidities of prematurity. Several groups have recently questioned the necessity or desirability of this target, shifting attention to aiming for growth which optimises important long-term outcomes. Read More

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February 2022

Predictors of anastomotic strictures following œsophageal atresia repair.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 25. Epub 2022 Feb 25.

Univ Lille, CHU Lille, Reference Centre for Chronic and Malformative Esophageal Diseases (CRACMO), Inserm U1286 Infinite, CHU Lille Pôle Enfant, Lille, France.

Objectives: To identify the risk factors for anastomotic, refractory and recurrent strictures and to establish whether anastomotic stricture is associated with antireflux surgery.

Design: This prospective national multicentre study included all infants born with oesophageal atresia (OA) over an 8-year period. Data on OA and complications were collected at birth and at 1 year old. Read More

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February 2022

Implications of the HELIX trial for treating infants with hypoxic-ischaemic encephalopathy in low-to-middle-income countries.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 21. Epub 2022 Feb 21.

Department of Physiology, The University of Auckland, Auckland, New Zealand

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February 2022

Is it necrotising enterocolitis? Is it focal intestinal perforation? Or is it something else? And does it matter?

Authors:
Nigel J Hall

Arch Dis Child Fetal Neonatal Ed 2022 05 21;107(3):234-235. Epub 2022 Feb 21.

University Surgery Unit, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, UK

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Is it time for routine probiotic use in UK neonatal units?

Authors:
Paul Fleming

Arch Dis Child Fetal Neonatal Ed 2022 Feb 21. Epub 2022 Feb 21.

Neonatal Unit, Homerton University Hospital, London, UK

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February 2022

Long QT syndrome presenting as fetal bradycardia and 2:1 atrioventricular block in a preterm infant.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 16. Epub 2022 Feb 16.

Department of Neonatology, University Hospital Waterford, Waterford, Waterford, Ireland

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February 2022

Preliminary study of automated oxygen titration at birth for preterm infants.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 9. Epub 2022 Feb 9.

Department of Paediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia

Objective: To study the feasibility of automated titration of oxygen therapy in the delivery room for preterm infants.

Design: Prospective non-randomised study of oxygenation in sequential preterm cohorts in which FiO was adjusted manually or by an automated control algorithm during the first 10 min of life.

Setting: Delivery rooms of a tertiary level hospital. Read More

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February 2022

Haemodynamic changes with varying chest compression rates in asphyxiated piglets.

Arch Dis Child Fetal Neonatal Ed 2022 Feb 8. Epub 2022 Feb 8.

Faculty of Engineering, Centre of the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, University of Alberta, Edmonton, Alberta, Canada

Background: Current neonatal resuscitation guidelines recommend that chest compressions (CCs) be delivered at a rate of 90/min. The aim of the study was to investigate the haemodynamic effects of different CC rates in a neonatal piglet model.

Methods: Six asphyxiated piglets were randomised to CC with rates of 60/min, 90/min, 120/min, 150/min and 180/min for 1 min at each rate. Read More

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February 2022

Lung volume distribution in preterm infants on non-invasive high-frequency ventilation.

Arch Dis Child Fetal Neonatal Ed 2022 Jan 31. Epub 2022 Jan 31.

Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland

Introduction: Non-invasive high-frequency oscillatory ventilation (nHFOV) is an extension of nasal continuous positive airway pressure (nCPAP) support in neonates. We aimed to compare global and regional distribution of lung volumes during nHFOV versus nCPAP.

Methods: In 30 preterm infants enrolled in a randomised crossover trial comparing nHFOV with nCPAP, electrical impedance tomography data were recorded in prone position. Read More

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January 2022

Severe neonatal hyperbilirubinaemia: lessons learnt from a national perinatal audit.

Arch Dis Child Fetal Neonatal Ed 2022 Jan 28. Epub 2022 Jan 28.

Department of Neonatology, University Medical Centre Groningen Beatrix Children's Hospital, Groningen, The Netherlands.

Objectives: To describe characteristics of neonates with severe neonatal hyperbilirubinaemia (SNH) and to gain more insight in improvable factors that may have contributed to the development of SNH.

Design And Setting: Descriptive study, based on national Dutch perinatal audit data on SNH from 2017 to 2019.

Patients: Neonates, born ≥35 weeks of gestation and without antenatally known severe blood group incompatibility, who developed hyperbilirubinaemia above the exchange transfusion threshold. Read More

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January 2022