24,148 results match your criteria Archives of Disease in Childhood[Journal]


Validation of the disposable T-piece resuscitator (Neo-Tee): a bench study.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 19. Epub 2019 Feb 19.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: The Neo-Tee Infant T-piece resuscitator is a disposable T-piece resuscitator. The aim of this bench study was to assess the accuracy of the Neo-Tee using a measurement set-up and settings mimicking clinical practice.

Study Design: Nine Neo-Tee devices were tested using a face mask interface and a manikin. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315298DOI Listing
February 2019

Towards evidence-based medicine for paediatricians.

Authors:
Bob Phillips

Arch Dis Child 2019 Mar;104(3):303

Centre for Reviews and Dissemination, University of York, York, UK.

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http://dx.doi.org/10.1136/archdischild-2019-316983DOI Listing

At what weight should preterm infants be transferred from incubator to open cot?

Authors:
Abdul Razak

Arch Dis Child 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatrics, Princess Nourah Bint Abdulrahman University, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1136/archdischild-2018-316691DOI Listing
February 2019

Should zinc be used as an adjunct therapy in severe pneumonia in Western Europe?

Arch Dis Child 2019 Feb 19. Epub 2019 Feb 19.

School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316642DOI Listing
February 2019
1 Read

How to use abdominal X-rays in preterm infants suspected of developing necrotising enterocolitis.

Arch Dis Child Educ Pract Ed 2019 Feb 18. Epub 2019 Feb 18.

Department of Neonatology, University College London Hospital, London, UK.

Necrotising enterocolitis (NEC) in preterm babies is a serious gastrointestinal emergency with potentially devastating consequences. Prompt and accurate diagnosis continues to be a challenge for health professionals. Early identification of clinical warning signs is extremely important, but the diagnosis relies heavily on the interpretation of abdominal radiographs. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315252DOI Listing
February 2019

Does appendicitis in a child with a ventriculoperitoneal shunt necessitate shunt revision?

Arch Dis Child 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatrics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316265DOI Listing
February 2019
1 Read

UK survey of less invasive surfactant administration.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 11. Epub 2019 Feb 11.

Department of Women and Children's Health, School of Life Sciences, Faculty of Life Science and Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316466DOI Listing
February 2019
3 Reads

Exploring the human factors of prescribing errors in paediatric intensive care units.

Arch Dis Child 2019 Feb 8. Epub 2019 Feb 8.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Objective: To explore the factors contributing to prescribing error in paediatric intensive care units (PICUs) using a human factors approach based on Reason's theory of error causation to support planning of interventions to mitigate slips and lapses, rules-based mistakes and knowledge-based mistakes.

Methods: A hierarchical task analysis (HTA) of prescribing was conducted using documentary analysis. Eleven semistructured interviews with prescribers were conducted using vignettes and were analysed using template analysis. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315981DOI Listing
February 2019

Establishment of a thalassaemia major quality improvement collaborative in Pakistan.

Arch Dis Child 2019 Feb 8. Epub 2019 Feb 8.

Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Objectives: The aim of this study was to establish multidisciplinary care for patients with transfusion-dependent thalassaemia (TDT) by creating a TDT quality improvement (QI) collaborative in a resource-constrained setting. This study presents our initial experience of creating this collaborative, the baseline characteristics of the participants, the proposed QI interventions and the outcome metrics of the collaborative.

Design And Setting: TDT QI collaborative is a database comprising patients with TDT from four centres in Karachi, Pakistan. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315743DOI Listing
February 2019

Current clinical practice in neonatologist-performed echocardiography in the UK.

Authors:
Yogen Singh

Arch Dis Child Fetal Neonatal Ed 2019 Feb 8. Epub 2019 Feb 8.

Neonatology/Paediatric Cardiology, Addenbrooke's, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316348DOI Listing
February 2019

Fifteen-minute consultation: A general paediatrician's guide to oncological abdominal masses.

Arch Dis Child Educ Pract Ed 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, University of Cambridge, Cambridge, UK.

The identification of an abdominal mass in a child, either coincidental or symptomatic, may be due to a tumour. An abdominal tumour may present with life-threatening symptoms, requiring prompt assessment and management. Although the discovery of such a finding usually warrants inpatient transfer or outpatient referral to the tertiary oncology centre, the initial evaluation, management and communication with the family by the general paediatrician is crucial. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315270DOI Listing
February 2019

Fifteen-minute consultation: Recognising primary immune deficiencies in children.

Arch Dis Child Educ Pract Ed 2019 Feb 7. Epub 2019 Feb 7.

Department of Paediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.

Children with primary immunodeficiency syndromes present with broad variation of clinical features and the consequences are often severe if not promptly recognised. Here, support is provided for the general paediatrician to recognise primary immunodeficiencies among the many children they meet in their clinical practice. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315484DOI Listing
February 2019
1 Read

Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 6. Epub 2019 Feb 6.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Objective: Infants with a congenital diaphragmatic hernia (CDH) are at high risk of developing pulmonary hypertension after birth, but little is known of their physiological transition at birth. We aimed to characterise the changes in cardiopulmonary physiology during the neonatal transition in an ovine model of CDH.

Methods: A diaphragmatic hernia (DH) was surgically created at 80 days of gestational age (dGA) in 10 fetuses, whereas controls underwent sham surgery (n=6). Read More

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http://dx.doi.org/10.1136/archdischild-2018-316045DOI Listing
February 2019
3 Reads

New short-term heat inactivation method of cytomegalovirus (CMV) in breast milk: impact on CMV inactivation, CMV antibodies and enzyme activities.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 6. Epub 2019 Feb 6.

Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tuebingen, Tubingen, Germany.

Objectives: Breast milk (BM) is the primary source of cytomegalovirus (CMV) transmission to premature infants with potentially harmful consequences. We therefore wanted to evaluate temperature and duration of short-term BM pasteurisation with respect to CMV inactivation, effect on CMV-IgG antibodies and BM enzyme activities.

Methods: 116 artificially CMV-spiked BM and 15 wild-type virus-infected samples were subjected for 5 s to different temperatures (55°C-72°C). Read More

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http://dx.doi.org/10.1136/archdischild-2018-316117DOI Listing
February 2019
1 Read

Effects of tracheal occlusion on the neonatal cardiopulmonary transition in an ovine model of diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 6. Epub 2019 Feb 6.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Objective: Fetoscopic endoluminal tracheal occlusion (FETO) aims to reverse pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) and mitigate the associated respiratory insufficiency and pulmonary hypertension after birth. We aimed to determine whether FETO improves the cardiopulmonary transition at birth in an ovine model of CDH.

Methods: In 12 ovine fetuses with surgically induced diaphragmatic hernia (DH; 80 dGA), an endotracheal balloon was placed tracheoscopically at ≈110 dGA and removed at ≈131 dGA (DH+FETO), while 10 were left untreated (DH). Read More

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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2018-31604
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http://dx.doi.org/10.1136/archdischild-2018-316047DOI Listing
February 2019
2 Reads

Hold that space(r): asthma in the press.

Arch Dis Child 2019 Feb 2. Epub 2019 Feb 2.

Paediatric Respiratory Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316494DOI Listing
February 2019

Appropriate CPR techniques for carers of infants outside of hospital.

Arch Dis Child 2019 Feb 2. Epub 2019 Feb 2.

Respiratory, Critical Care and Anaesthesia Section in Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/archdischild-2018-315756DOI Listing
February 2019
1 Read

Evaluation of the Dutch neonatal screening for congenital adrenal hyperplasia.

Arch Dis Child 2019 Feb 2. Epub 2019 Feb 2.

TNO, Department of Child Health, Leiden, The Netherlands.

Background: In 2002, a nationwide screening for congenital adrenal hyperplasia (CAH) was introduced in the Netherlands. The aim of our study is to evaluate the validity of the neonatal screening for CAH and to assess how many newborns with salt-wasting (SW) CAH have already been clinically diagnosed before the screening result was known.

Methods: Retrospective, descriptive study. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315972DOI Listing
February 2019

From skin to bone: a boy with an unusual cause of acne.

Arch Dis Child 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics, Azienda per l'Assistenza Sanitaria n 5 Friuli Occidentale, Pordenone, Italy.

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http://dx.doi.org/10.1136/archdischild-2018-316620DOI Listing
February 2019

Can we estimate the length of stay of very preterm multiples?

Arch Dis Child Fetal Neonatal Ed 2019 Feb 2. Epub 2019 Feb 2.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316321DOI Listing
February 2019

Antibiotic prescribing for upper respiratory tract infections: NICE guidelines.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

Paediatric Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31615
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http://dx.doi.org/10.1136/archdischild-2018-316159DOI Listing
February 2019
3 Reads

Case of knee swelling.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

Department of Paediatrics, Russells Hall Hospital, Dudley, UK.

Questions: What does the X-ray show?InfectionPeriarticular soft tissue calcificationArtefactGout What condition is associated with these radiological findings?Tumorous calcinosisSynovial sarcomaChronic renal failureJuvenile dermatomyositisAll of the above What biochemical abnormality is seen in this condition?Low calciumRaised calciumRaised or normal phosphateNone of the above What is the most appropriate treatment?Normalisation of any biochemical abnormalitiesSurgical excisionConservative managementAll of the above Read More

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31626
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http://dx.doi.org/10.1136/archdischild-2018-316268DOI Listing
February 2019
3 Reads

Rituximab is more effective than tacrolimus in steroid-dependent nephrotic syndrome.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316537DOI Listing
February 2019
3 Reads

Child presenting with breathlessness 1 month after cardiac surgery.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

School of Medicine, University of Trieste, Trieste, Italy.

Questions: 1. What is your diagnosis?Atelectasis.Pneumothorax. Read More

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31615
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http://dx.doi.org/10.1136/archdischild-2018-316156DOI Listing
February 2019
4 Reads

Child with intermittent diplopia after otitis media.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.

QUESTION 1: What is the diagnosis in this patient?Brain abscessAcute suppurative mastoiditisOptic neuritisCerebral venous sinus thrombosisSubdural haematoma QUESTION 2: What are the most common clinical presentations of this condition? QUESTION 3: How should this patient be managed? Read More

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31630
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http://dx.doi.org/10.1136/archdischild-2018-316307DOI Listing
February 2019
2 Reads

Transcriptome: from laboratory to clinic room.

Arch Dis Child Educ Pract Ed 2019 Feb 1. Epub 2019 Feb 1.

Department of Clinical Genetics, Royal Hospital for Children, Glasgow, UK.

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http://ep.bmj.com/lookup/doi/10.1136/archdischild-2017-31389
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http://dx.doi.org/10.1136/archdischild-2017-313890DOI Listing
February 2019
2 Reads

Asymptomatic subcutaneous nodules on the feet of an infant.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, University of Florida, Gainesville, Florida, USA.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3166
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http://dx.doi.org/10.1136/archdischild-2018-316699DOI Listing
January 2019
3 Reads

Parallel planning and the paediatric critical care patient.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Louis Dundas Centre for Children's Palliative Care, Great Ormond Street Hospital, London, UK.

A growing number of children with life-limiting conditions (LLCs) are being cared for in paediatric critical care (PCC) settings. Children with LLCs admitted to PCC are at a high risk of developing complications and many die after prolonged admissions. Relatively few of these patients and their parents or carers have had documented discussions about their wishes for care in the event of a serious clinical deterioration before admission to PCC. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315222DOI Listing
January 2019
3 Reads

Distinct neuroimaging features of gene-related spastic paraplegia, a mimicker of cerebral palsy.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3164
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http://dx.doi.org/10.1136/archdischild-2018-316484DOI Listing
January 2019
12 Reads

Treatment abandonment in childhood acute lymphoblastic leukaemia in China: a retrospective cohort study of the Chinese Children's Cancer Group.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology and Oncology of China Ministry of Health, and National Children's Medical Center, Shanghai, China.

Objectives: Before 2003, most children with acute lymphoblastic leukaemia (ALL) abandoned treatment, with only approximately 30% treated in China. With the development of national insurance for underprivileged patients, we assessed the current frequency and causes of treatment abandonment among patients with ALL who were enrolled in the Chinese Children's Cancer Group ALL protocol between 2015 and 2016.

Methods: Demographic, clinical and laboratory data on patients who abandoned treatment, as well as economic and sociocultural data of their families were collected and analysed. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316181DOI Listing
January 2019
2 Reads

One-year surveillance of body mass index and cardiorespiratory fitness in UK primary school children in North West England and the impact of school deprivation level.

Arch Dis Child 2019 Jan 31. Epub 2019 Jan 31.

Research Institute, ukactive, London, UK.

Objectives: Cardiorespiratory fitness (CRF) is independently associated with health and academic attainment in childhood and adolescence. Yet overweight/obesity remains the focus in public health policy. Surveillance of body mass index (BMI) and CRF considering school deprivation levels is limited. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315567DOI Listing
January 2019

Obesity and asthma.

Authors:

Arch Dis Child 2019 Mar 30;104(3):274. Epub 2019 Jan 30.

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http://dx.doi.org/10.1136/archdischild-2019-316812DOI Listing

New perspectives on Kawasaki disease.

Authors:
Jane C Burns

Arch Dis Child 2019 Jan 30. Epub 2019 Jan 30.

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http://dx.doi.org/10.1136/archdischild-2018-316322DOI Listing
January 2019
1 Read

Child mortality: how does the USA compare?

Authors:

Arch Dis Child 2019 Mar 30;104(3):236. Epub 2019 Jan 30.

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http://dx.doi.org/10.1136/archdischild-2019-316813DOI Listing

How to use clinical signs of meningitis.

Arch Dis Child Educ Pract Ed 2019 Jan 28. Epub 2019 Jan 28.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Meningitis is a critical diagnosis not to miss in children presenting with fever. Since the early 20th century, classical clinical signs have been used to aid the diagnosis of meningitis. These classical signs are nuchal rigidity, Kernig's sign and Brudzinski's sign. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315428DOI Listing
January 2019
1 Read

Paediatric postintubation subglottic stenosis.

Arch Dis Child 2019 Jan 28. Epub 2019 Jan 28.

Department of Otolaryngology, Head and Neck Surgery, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1136/archdischild-2018-316517DOI Listing
January 2019

Necrosis of infantile haemangioma with propranolol therapy.

Arch Dis Child 2019 Jan 28. Epub 2019 Jan 28.

Department of Child and Adolescent Health, Mater Dei Hospital, Msida, Malta.

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http://dx.doi.org/10.1136/archdischild-2018-316478DOI Listing
January 2019

Incomplete congenital duodenal obstruction: a diagnostic challenge.

Arch Dis Child 2019 Jan 28. Epub 2019 Jan 28.

Pediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Dona Estefania, Lisboa, Portugal.

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http://dx.doi.org/10.1136/archdischild-2018-316497DOI Listing
January 2019

Refreshing.

Authors:
Bob Phillips

Arch Dis Child 2019 Feb;104(2):193

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http://dx.doi.org/10.1136/archdischild-2018-316763DOI Listing
February 2019

Spots and bends.

Arch Dis Child Educ Pract Ed 2019 Jan 19. Epub 2019 Jan 19.

Radiology, West Middlesex University Hospital, Isleworth, UK.

Questions: What is the differential diagnosis for infantile tibial bowing and what are the clinical clues that aid diagnosis?What is the most likely diagnosis in this case? How will you confirm the diagnosis?What is the significance for future surveillance and prognosis?What is the mechanism and complications of this bone abnormality? Read More

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http://dx.doi.org/10.1136/archdischild-2018-316277DOI Listing
January 2019
1 Read

Predicting cardiometabolic markers in children using tri-ponderal mass index: a cross-sectional study.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Perinatal Epidemiology Research Unit, Departments of Obstetrics and Gynaecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To model the development of the tri-ponderal mass index (TMI, kg/m) throughout childhood and adolescence and to compare the utility of the TMI with that of the body mass index (BMI, kg/m) to predict cardiometabolic risk in a population-based sample of Canadian children and youth.

Methods: We used data from the Canadian Health Measures Survey to model TMI from 6 to 19 years of age. Percentile curves were developed using the LMS method. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3160
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http://dx.doi.org/10.1136/archdischild-2018-316028DOI Listing
January 2019
5 Reads

High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To review the effects and safety of high-flow nasal cannula (HFNC) for bronchiolitis.

Methods: Six electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, CQ VIP Database and Wanfang Data were searched from their inception to 1 June 2018. Randomised controlled trials (RCTs) which investigated the effects of HFNC versus other forms of oxygen therapies for bronchiolitis were included. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3158
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http://dx.doi.org/10.1136/archdischild-2018-315846DOI Listing
January 2019
10 Reads

Puberty blocking in gender dysphoria: suitable for all?

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

National Gender Identity Development Service, Tavistock and Portman NHS Foundation Trust, London, UK.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3159
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http://dx.doi.org/10.1136/archdischild-2018-315984DOI Listing
January 2019
5 Reads

Use of puberty blockers for gender dysphoria: a momentous step in the dark.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Retired, Child and Adolescent Mental Health Service, Southern Health and Social Care Trust, Portadown, Northern Ireland, UK.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3158
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http://dx.doi.org/10.1136/archdischild-2018-315881DOI Listing
January 2019
14 Reads

Calprotectin instability may lead to undertreatment in children with IBD.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Treatment decisions in children with inflammatory bowel disease (IBD) are increasingly based on longitudinal tracking of faecal calprotectin concentrations, but there is little known about the stability of this protein in stool.

Methods: We stored aliquots of homogenised stool at room temperature and at 4°C, and measured the calprotectin concentration for 6 consecutive days with three different assays. In addition, we assessed calprotectin stability in assay-specific extraction buffers kept at room temperature. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316584DOI Listing
January 2019
6 Reads

Hourglass neck mass.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Department of Otolaryngology, University Hospital of Larissa, Larissa, Greece.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3164
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http://dx.doi.org/10.1136/archdischild-2018-316433DOI Listing
January 2019
5 Reads

Lingual thyroid: ectopic gland in the tongue base.

Authors:
Rabbi Swaby

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Paediatrics, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3165
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http://dx.doi.org/10.1136/archdischild-2018-316508DOI Listing
January 2019
4 Reads

Paediatrician's guide to epigenetics.

Arch Dis Child 2019 Mar 17;104(3):297-301. Epub 2019 Jan 17.

University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.

Epigenetic regulation of gene expression is critical for normal development. Dysregulation of the epigenome can lead to the development and progression of a number of diseases relevant to paediatricians, including disorders of genomic imprinting and malignancies. It has long been recognised that early life events have implications for future disease risk, and epigenetic modifications may play a role in this, although further high-quality research is needed to better understand the underlying mechanisms. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316054DOI Listing
March 2019
4 Reads

Intrathoracic renal ectopia with congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Jan 13. Epub 2019 Jan 13.

Neonatal Intensive Care Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2018-31619
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http://dx.doi.org/10.1136/archdischild-2018-316195DOI Listing
January 2019
7 Reads