3,418 results match your criteria Archives of Disease in Childhood: Fetal and Neonatal Edition[Journal]


Safe and effective glycaemic control in premature infants: observational clinical results from the computerised STAR-GRYPHON protocol.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 21. Epub 2018 Jun 21.

Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.

Objective: Previous studies examine clinical outcomes of insulin therapy in neonatal intensive care units (NICUs), without first developing safe and effective control protocols. This research quantifies the safety and performance of a computerised model-based control algorithmSTAR-GRYPHON (Stochastic TARgeted Glucose Regulation sYstem to Prevent Hyper- and hypO-glycaemia in Neonates).

Design: Retrospective observational study of glycaemic control in very/extremely low birthweight infants treated with insulin from Christchurch Women's Hospital NICU between January 2013 and June 2017. Read More

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Hypoxemic and hyperoxemic likelihood in pulse oximetry ranges: NICU observational study.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 20. Epub 2018 Jun 20.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Objective: Describe the likelihood of hypoxemia and hyperoxemia across ranges of oxygen saturation (SpO), during mechanical ventilation with supplemental oxygenation.

Design: Retrospective observational study.

Setting: University affiliated tertiary care neonatal intensive care unit. Read More

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Dose-interval study of a dual probiotic in preterm infants.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 20. Epub 2018 Jun 20.

Infant Centre and Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.

Objective: The objective of this study was to investigate the appropriate dosing interval of a probiotic (Infloran) given daily, biweekly and weekly in preterm infants <32 weeks' gestation.

Methods: There were 8 infants in the daily group, 8 infants in the biweekly group and 10 infants in the weekly group, all born between 25 and 32 weeks' gestation. The control group consisted of 12 preterm infants who did not receive the probiotic. Read More

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Screening for colonisation with gentamicin-resistant Gram-negative organisms on the neonatal unit: does positive screening predict sepsis?

Arch Dis Child Fetal Neonatal Ed 2018 Jun 20. Epub 2018 Jun 20.

Department of Neonatology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.

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June 2018
1 Read

Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 15. Epub 2018 Jun 15.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: To summarise current evidence evaluating the effects of human milk on the risk of bronchopulmonary dysplasia (BPD) in preterm infants.

Design: We searched for studies on human milk and BPD in English and Chinese databases on 26 July 2017. Furthermore, the references of included studies were also screened. Read More

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June 2018
1 Read

Visual attention on a respiratory function monitor during simulated neonatal resuscitation: an eye-tracking study.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 14. Epub 2018 Jun 14.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: A respiratory function monitor (RFM) may improve positive pressure ventilation (PPV) technique, but many providers do not use RFM data appropriately during delivery room resuscitation. We sought to use eye-tracking technology to identify RFM parameters that neonatal providers view most commonly during simulated PPV.

Design: Mixed methods study. Read More

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June 2018
6 Reads

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 14. Epub 2018 Jun 14.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To investigate whether umbilical cord milking (UCM) at birth improves systemic blood flow and short-term outcomes, as compared with immediate cord clamping (ICC).

Design: Randomised clinical trial.

Setting: Single tertiary care centre. Read More

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Pulseless electrical activity: a misdiagnosed entity during asphyxia in newborn infants?

Arch Dis Child Fetal Neonatal Ed 2018 Jun 12. Epub 2018 Jun 12.

Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada.

Background: The 2015 neonatal resuscitation guidelines added ECG as a recommended method of assessment of an infant's heart rate (HR) when determining the need for resuscitation at birth. However, a recent case report raised concerns about this technique in the delivery room.

Objectives: To compare accuracy of ECG with auscultation to assess asystole in asphyxiated piglets. Read More

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Prediction of bronchopulmonary dysplasia development.

Arch Dis Child Fetal Neonatal Ed 2018 Jun 12. Epub 2018 Jun 12.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.

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Massive congenital depression of neonate's skull.

Arch Dis Child Fetal Neonatal Ed 2018 Jul 31;103(4):F316. Epub 2018 May 31.

Department of Obstetrics and Gynecology, Poissy-Saint Germain Hospital, Poissy, France.

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July 2018
2 Reads

Does the use of an iodine-containing contrast agent to visualise the PICC tip in preterm babies cause hypothyroidism? A randomised controlled trial.

Arch Dis Child Fetal Neonatal Ed 2018 May 28. Epub 2018 May 28.

Department of Neonatology, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.

Aim: To compare thyroid function tests in preterm neonates (<30 weeks and >48 hour old) exposed to iodine-based contrast with controls and ascertain the certainty of peripherally inserted central catheter (PICC) tip position.

Methods: Infants requiring a PICC were randomised to receive 0.3 mL of iodine-containing contrast or normal saline. Read More

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May 2018
2 Reads

Learning from claims: hyperbilirubinaemia and kernicterus.

Arch Dis Child Fetal Neonatal Ed 2018 May 25. Epub 2018 May 25.

Maternity and Newborn, NHS Improvement, London, UK.

We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Read More

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May 2018
1 Read

Comparison of infant heart rate assessment by auscultation, ECG and oximetry in the delivery room.

Arch Dis Child Fetal Neonatal Ed 2018 May 25. Epub 2018 May 25.

Neonatal Unit, The National Maternity Hospital, Dublin, Ireland.

Clinical assessment of an infant's heart rate (HR) in the delivery room (DR) has been reported to be inaccurate. We compared auscultation of the HR using a stethoscope with electrocardiography (ECG) and pulse oximetry (PO) for determining the HR in 92 low-risk newborn infants in the DR. Caregivers auscultated the HR while masked to the HR on the monitor. Read More

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May 2018
1 Read

Heart rate changes during positive pressure ventilation after asphyxia-induced bradycardia in a porcine model of neonatal resuscitation.

Arch Dis Child Fetal Neonatal Ed 2018 May 19. Epub 2018 May 19.

Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada.

Background: The Neonatal Resuscitation Program (NRP) states that if adequate positive pressure ventilation (PPV) was given for a low heart rate (HR), the infant's HR should increase within the first 15 s of PPV.

Objective: To assess changes in HR in piglets with asphyxia-induced bradycardia.

Methods: Term newborn piglets (n=30) were anaesthetised, intubated, instrumented and exposed to 50 min normocapnic hypoxia followed by asphyxia. Read More

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May 2018
2 Reads

Outcomes following antenatal identification of hydrops fetalis: a single-centre experience from 2001 to 2012.

Arch Dis Child Fetal Neonatal Ed 2018 May 16. Epub 2018 May 16.

Newborn Research Centre and Neonatal Services, The Royal Women's Hospital, Parkville, Melbourne, Victoria, Australia.

Objective: To describe the aetiologies and outcomes of pregnancies complicated by hydrops fetalis (HF).

Study Design: Case series of all pregnancies complicated by HF managed at The Royal Women's Hospital (RWH), Melbourne, Australia, between 2001 and 2012. Multiple pregnancies, and cases where antenatal care was not provided at RWH were excluded. Read More

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May 2018
2 Reads

Human milk is perhaps the single most under-rated strategy to prevent bronchopulmonary dysplasia.

Arch Dis Child Fetal Neonatal Ed 2018 May 5. Epub 2018 May 5.

Neonatal Unit, Department of Pediatrics, Hospital de la Santa Cruz y San Pablo, Barcelona, Spain.

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May 2018
1 Read

Adverse effects of small for gestational age differ by gestational week among very preterm infants.

Arch Dis Child Fetal Neonatal Ed 2018 May 5. Epub 2018 May 5.

Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation.

Methods: Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies. Read More

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May 2018
1 Read

T-piece resuscitators: how do they compare?

Arch Dis Child Fetal Neonatal Ed 2018 May 4. Epub 2018 May 4.

Neonatal Intensive Care Unit, Westmead Hospital, Westmead, New South Wales, Australia.

Background: The T-piece resuscitator (TPR) has seen increased use as a primary resuscitation device with newborns. Traditional TPR design uses a high resistance expiratory valve to produce positive end expiratory pressure (PEEP) or continuous positive airway pressure (CPAP) at resuscitation. A new TPR device that uses a dual flow ratio valve (fluidic flip) to produce PEEP/CPAP is now available (rPAP). Read More

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May 2018
1 Read

A video is worth a thousand words: innovative uses of videolaryngoscopy.

Arch Dis Child Fetal Neonatal Ed 2018 May 4. Epub 2018 May 4.

Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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May 2018
1 Read

Challenge of determining true outcome of congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2018 May 4. Epub 2018 May 4.

Department of Paediatric Surgery, Scottish Paediatric ECLS Service, Royal Hospital for Children, Glasgow, UK.

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May 2018
1 Read

Clinical aspects of incorporating cord clamping into stabilisation of preterm infants.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 21. Epub 2018 Apr 21.

Division of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands.

Fetal to neonatal transition is characterised by major pulmonary and haemodynamic changes occurring in a short period of time. In the international neonatal resuscitation guidelines, comprehensive recommendations are available on supporting pulmonary transition and delaying clamping of the cord in preterm infants. Recent experimental studies demonstrated that the pulmonary and haemodynamic transition are intimately linked, could influence each other and that the timing of umbilical cord clamping should be incorporated into the respiratory stabilisation. Read More

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April 2018
1 Read

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 17. Epub 2018 Apr 17.

Clinical Research Unit, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.

Background: Systemic corticosteroids as the frontline treatment of respiratory distress syndrome (RDS) in preterm infants are associated with adverse effects on growth and neurodevelopmental outcome, but the pulmonary administration of steroids may help prevent the development of bronchopulmonary dysplasia (BPD) without these side effects.

Objectives: To evaluate the efficacy and safety of pulmonary application of corticosteroids in preterm infants with RDS.

Methods: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials. Read More

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April 2018
2 Reads

Nutritional role of amniotic fluid: clues from infants with congenital obstruction of the digestive tract.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 17. Epub 2018 Apr 17.

Department of Paediatric Surgery and Urology, Southampton General Hospital, University of Southampton, Southampton, UK.

Aims: To investigate the role played by amniotic fluid in late fetal nutrition by analysis of infants born with digestive tract atresia.

Methods: Birth weight (BW), gestational age and gender of infants born with oesophageal (OA), duodenal (DA), jejunal (JA) and ileal atresia (IA) were recorded and BW Z-scores compared. Infants with incomplete obstruction (stenosis), chromosomal or syndromic conditions and multiple congenital malformations were excluded. Read More

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April 2018
3 Reads

Breastfeeding rates at discharge: don't blame the fortifier! A national survey of practice and comparison with NNAP data.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 11. Epub 2018 Apr 11.

Neonatal Unit, St George's Hospital, London, UK.

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April 2018
2 Reads

Case of membranous oesophageal atresia.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 11. Epub 2018 Apr 11.

Department of Neonatal Surgery, Guangdong Women and Children Hospital, Guangzhou, China.

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April 2018
1 Read

Safety of meningococcal group B vaccination in hospitalised premature infants.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 10. Epub 2018 Apr 10.

Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, University of London, London, UK.

Objectives: To assess the risk of significant adverse events in premature infants receiving the novel 4-component group B meningococcal vaccine (4CMenB) with their routine immunisations at 2 months of age.

Participants, Design And Setting: In December 2015, Public Health England requested neonatal units across England to voluntarily participate in a national audit; 19 units agreed to participate. Anonymised questionnaires were completed for infants receiving 4CMenB alongside their routine immunisations. Read More

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April 2018
2 Reads

Trainees success rates with intubation to suction meconium at birth.

Arch Dis Child Fetal Neonatal Ed 2018 Apr 10. Epub 2018 Apr 10.

Department of Pediatrics, Division of Neonatology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Objectives: To assess the success rate and main reasons for failure of intubation performed by medical trainees to suction meconium below the vocal cords in non-vigorous infants delivered at ≥36 week gestation.

Design: We conducted a prospective cohort study involving 54 residents and nine neonatology fellows in a Canadian level 3 neonatal intensive care unit. Endotracheal intubation to suction meconium was performed using a videolaryngoscope, the video screen being covered during the procedure. Read More

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April 2018
2 Reads

Improving endotracheal tube placement in neonates.

Arch Dis Child Fetal Neonatal Ed 2018 Jul 6;103(4):F395. Epub 2018 Apr 6.

Neonatal Unit, Royal London Hospital, Barts Health NHS Trust, London, UK.

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July 2018
1 Read

Postnatal steroids: still a dilemma for neonatologists and parents?

Authors:
Henry L Halliday

Arch Dis Child Fetal Neonatal Ed 2018 Apr 6. Epub 2018 Apr 6.

Department of Child Health, Queen's University of Belfast, Belfast BT7 1NN, UK.

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April 2018
2 Reads

Estimating neonatal length of stay for babies born very preterm.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 27. Epub 2018 Mar 27.

Department of Health Sciences, University of Leicester, Leicester, UK.

Objective: To predict length of stay in neonatal care for all admissions of very preterm singleton babies.

Setting: All neonatal units in England.

Patients: Singleton babies born at 24-31 weeks gestational age from 2011 to 2014. Read More

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March 2018
5 Reads

Early-onset neonatal infections in Australia and New Zealand, 2002-2012.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 27. Epub 2018 Mar 27.

Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: The epidemiology of early-onset neonatal sepsis (EONS) varies over time, and requires regular surveillance.

Objective: To analyse data on EONS in Australia and New Zealand.

Methods: Retrospective analysis of data collected longitudinally from multiple neonatal units from 2002 to 2012. Read More

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March 2018
1 Read

Unexpected heart block in the delivery room: the utility of ECG monitoring.

Arch Dis Child Fetal Neonatal Ed 2018 May 22;103(3):F292. Epub 2018 Mar 22.

Neonatal-Perinatal Medicine, Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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May 2018
2 Reads

Implementation of Learning from Excellence initiative in a neonatal intensive care unit.

Arch Dis Child Fetal Neonatal Ed 2018 May 22;103(3):F293. Epub 2018 Mar 22.

Neonatology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

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May 2018
2 Reads

Omphalocele: from diagnosis to growth and development at 2 years of age.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 21. Epub 2018 Mar 21.

Department of Paediatric Surgery and Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

Objectives: To compare the prenatal frame of reference of omphalocele (ie, survival of fetuses) with that after birth (ie, survival of liveborn neonates), and to assess physical growth and neurodevelopment in children with minor or giant omphalocele up to 2 years of age.

Design: We included fetuses and neonates diagnosed in 2000-2012. Physical growth (SD scores, SDS) and mental and motor development at 12 and 24 months were analysed using general linear models, and outcomes were compared with reference norms. Read More

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March 2018
4 Reads

Accuracy of five formulae to determine the insertion length of umbilical venous catheters.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 17. Epub 2018 Mar 17.

Newborn Research Centre, The Royal Women's Hospital, Parkville, Victoria, Australia.

Introduction: Umbilical venous catheter (UVC) placement is a common neonatal procedure. It is important to position the UVC tip accurately at the first attempt to prevent complications and minimise handling. Catheters positioned too low need to be removed, but catheters positioned too high may be withdrawn in a sterile fashion to a safe position. Read More

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March 2018
2 Reads

Detection of exhaled carbon dioxide following intubation during resuscitation at delivery.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 17. Epub 2018 Mar 17.

MRC & Asthma UK Centre in Allergic Mechanisms in Asthma, King's College London, London, UK.

Objectives: End tidal carbon dioxide (ETCO) monitoring can facilitate identification of successful intubation. The aims of this study were to determine the time to detect ETCO following intubation during resuscitation of infants born prematurely and whether it differed according to maturity at birth or the Apgar scores (as a measure of the infant's condition after birth).

Design: Analysis of recordings of respiratory function monitoring. Read More

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March 2018
2 Reads

Development of a gastroschisis core outcome set.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 14. Epub 2018 Mar 14.

National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.

Objective: Outcome reporting heterogeneity impedes identification of gold standard treatments for children born with gastroschisis. Use of core outcome sets (COSs) in research reduces outcome reporting heterogeneity and ensures that studies are relevant to patients. The aim of this study was to develop a gastroschisis COS. Read More

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March 2018
1 Read

Evaluation of the congenital hypothyroidism screening programme in Iran: a 3-year retrospective cohort study.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 14. Epub 2018 Mar 14.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, The Islamic Republic of Iran.

Objective: To evaluate the newborn screening programme for congenital hypothyroidism (CH) in Iran from diagnosis to management and follow-up for 3 years from 2011 to 2014.

Design: Retrospective cohort.

Setting And Patients: Seventeen university districts were randomly selected from 30 provinces. Read More

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March 2018
2 Reads

Little and large: the effects of twin growth discordance.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 9. Epub 2018 Mar 9.

Department of Paediatrics, Rotunda Hospital, Dublin, Ireland.

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March 2018
2 Reads

Predictors of extubation readiness in preterm infants: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 8. Epub 2018 Mar 8.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Context: A variety of extubation readiness tests have already been incorporated into clinical practice in preterm infants.

Objective: To identify predictor tests of successful extubation and determine their accuracy compared with clinical judgement alone.

Methods: MEDLINE, Embase, PubMed, Cochrane Library and Web of Science were searched between 1984 and June 2016. Read More

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March 2018
2 Reads

Cognitive outcome in childhood of birth weight discordant monochorionic twins: the long-term effects of fetal growth restriction.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 2. Epub 2018 Mar 2.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Aim: Intrauterine growth restriction (IUGR) is associated with poorer outcomes in later life. We used a monochorionic twin model with IUGR in one twin to determine its impact on growth and neurocognitive outcomes.

Methods: Monochorionic twins with ≥20% birth weight discordance born in the north of England were eligible. Read More

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March 2018
2 Reads

Delivery of positive end-expiratory pressure to preterm lambs using common resuscitation devices.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 2. Epub 2018 Mar 2.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Background: In neonatal resuscitation, a ventilation device providing positive end-expiratory pressure (PEEP) is recommended. There is limited information about PEEP delivery in vivo, using different models of self-inflating bag (SIB) at different inflation rates and PEEP settings.

Methods: We compared PEEP delivery to intubated preterm lambs using four commonly available models of paired SIBs and PEEP valves, with a T-piece, with gas flow of 8 L/min. Read More

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March 2018
2 Reads

Research on infection prevention bundles: hidden risk of bias?

Authors:
Pieter Degraeuwe

Arch Dis Child Fetal Neonatal Ed 2018 Feb 27. Epub 2018 Feb 27.

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February 2018
3 Reads

Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2018 Feb 23. Epub 2018 Feb 23.

Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: To determine the comparative efficacy and safety of corticosteroids in the prevention of bronchopulmonary dysplasia (BPD) in preterm infants.

Study Design: We systematically searched PubMed, EMBASE and the Cochrane Library. Two reviewers independently selected randomised controlled trials (RCTs) of postnatal corticosteroids in preterm infants. Read More

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February 2018
9 Reads

Treatment thresholds for intervention in posthaemorrhagic ventricular dilation: a randomised controlled trial.

Arch Dis Child Fetal Neonatal Ed 2018 02 10. Epub 2018 Feb 10.

Department of Neonatology, Southmead Hospital, School of Clinical Science, University of Bristol, Bristol, UK.

Objective: To compare a low versus a higher threshold for intervention in preterm infants with posthaemorrhagic ventricular dilatation.

Design: Multicentre randomised controlled trial (ISRCTN43171322).

Setting: 14 neonatal intensive care units in six countries. Read More

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February 2018
4 Reads

High versus standard dose caffeine for apnoea: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2018 Feb 7. Epub 2018 Feb 7.

Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Noord-Holland, The Netherlands.

Background: Placebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).

Objective: To identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages.

Methods: A systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies. Read More

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February 2018
2 Reads

Why are preterm newborns at increased risk of infection?

Arch Dis Child Fetal Neonatal Ed 2018 Jul 30;103(4):F391-F394. Epub 2018 Jan 30.

Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

One in 10 newborns will be born before completion of 36 weeks' gestation (premature birth). Infection and sepsis in preterm infants remain a significant clinical problem that represents a substantial financial burden on the healthcare system. Many factors predispose premature infants for having the greatest risk of developing and succumbing to infection as compared with all other age groups across the age spectrum. Read More

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July 2018
3 Reads

Radiological feature of colonic atresia.

Arch Dis Child Fetal Neonatal Ed 2018 May 27;103(3):F263. Epub 2018 Jan 27.

Department of Neonatal Surgery, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.

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May 2018
4 Reads

Morbidity and mortality with early pulmonary haemorrhage in preterm neonates.

Arch Dis Child Fetal Neonatal Ed 2018 Jan 27. Epub 2018 Jan 27.

Pediatrix Medical Group, Dallas, Texas, USA.

Objective: There are no large studies evaluating pulmonary haemorrhage (PH) in premature infants. We sought to quantify the clinical characteristics, morbidities and mortality associated with early PH.

Design: Data were abstracted from the Pediatrix Clinical Data Warehouse, a large de-identified data set. Read More

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January 2018
3 Reads

Catheter sepsis and antisepsis: matters of life, death, obscurity and resistance.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 25;103(2):F94-F96. Epub 2018 Jan 25.

Norwich Medical School, University of East Anglia, Norwich, UK.

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March 2018
3 Reads