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    3335 results match your criteria Archives of Disease in Childhood: Fetal and Neonatal Edition[Journal]

    1 OF 67

    Tobacco, alcohol and illicit drugs during pregnancy and risk of neuroblastoma: systematic review.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Pathology, Brandenburg Medical School, Brandenburg, Germany.
    Objective: To determine whether prenatal and perinatal maternal consumption of alcohol, tobacco and/or illicit drugs is associated with risk of neuroblastoma.

    Data Sources: Medline and Embase (both from inception to February 2017), and reference lists of included studies.

    Study Selection: To be eligible, a study had to be an original report including data on intake of alcohol, tobacco smoking and/or consumption of illicit drugs during pregnancy and risk of neuroblastoma in the child. Read More

    Role of ECMO in congenital diaphragmatic hernia.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 14. Epub 2017 Nov 14.
    Paediatric Surgery, Royal Hospital for Sick Children Edinburgh, Edinburgh, UK.
    Congenital diaphragmatic hernia (CDH) is typified morphologically by failure of diaphragmatic development with accompanying lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Patients who have labile physiology and low preductal saturations despite optimal ventilatory and inotropic support may be considered for extracorporeal membrane oxygenation (ECMO). Systematic reviews into the benefits of ECMO in CDH concluded that any benefit is unclear. Read More

    Analysis of unsuccessful intubations in neonates using videolaryngoscopy recordings.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 10. Epub 2017 Nov 10.
    Newborn Research Centre, Royal Women's Hospital, Melbourne, Victoria, Australia.
    Objectives: Neonatal intubation is a difficult skill to learn and teach. If an attempt is unsuccessful, the intubator and instructor often cannot explain why. This study aims to review videolaryngoscopy recordings of unsuccessful intubations and explain the reasons why attempts were not successful. Read More

    Objective cardiovascular assessment in the neonatal intensive care unit.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 10. Epub 2017 Nov 10.
    Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
    Traditionally, cardiovascular well-being was essentially based on whether the mean blood pressure was above or below a certain value. However, this singular crude method of assessment provides limited insight into overall cardiovascular well-being. Echocardiography has become increasingly used and incorporated into clinical care. Read More

    Retrospective cohort analysis on pancreatic enzyme substitution in very low birthweight infants with postnatal growth failure.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 9. Epub 2017 Nov 9.
    Department of Neonatology, Center for Pediatric Clinical Studies, University Children's Hospital, Tuebingen, Germany.
    Objective: To evaluate the effects of pancreatic enzyme substitution (PES) in selected very low birthweight (VLBW) infants with poor postnatal growth despite intensified nutritional support.

    Design: Retrospective historic cohort study with matched controls.

    Setting: Single level III neonatal intensive care unit. Read More

    Referrals to a perinatal specialist palliative care consult service in Ireland, 2012-2015.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 9. Epub 2017 Nov 9.
    Paediatric Palliative Medicine, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
    Objective: To analyse the referral patterns of perinatal patients referred to a specialist palliative care service (SPCS), their demographics, diagnoses, duration of illness, place of death and symptom profile.

    Design: A retrospective chart review of all perinatal referrals over a 4-year period to the end of 2015.

    Setting: A consultant-led paediatric SPCS at Our Lady's Children's Hospital, Crumlin, Dublin, and the Coombe Women & Infants University Hospital, Dublin. Read More

    One-year outcomes following surgery for necrotising enterocolitis: a UK-wide cohort study.
    Arch Dis Child Fetal Neonatal Ed 2017 Nov 1. Epub 2017 Nov 1.
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.
    Objective: The objective was to describe outcomes and investigate factors affecting prognosis at 1 year post intervention for infants with surgical necrotising enterocolitis (NEC).

    Design: Using the British Association of Paediatric Surgeons Congenital Anomalies Surveillance System, we conducted a prospective, multicentre cohort study of every infant reported to require surgical intervention for NEC in the UK and Ireland between 1 March 2013 and 28 February 2014. Association of independent variables with 1-year mortality was investigated using multivariable logistic regression analysis. Read More

    Devices used for stabilisation of newborn infants at birth.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 27. Epub 2017 Oct 27.
    Department of Neonatology, James Cook University Hospital, Middlesbrough, UK.
    This review examines devices used during newborn stabilisation. Evidence for their use to optimise the thermal, respiratory and cardiovascular management in the delivery room is presented. Mechanisms of action and rationale of use are described, current developments are presented and areas of future research are highlighted. Read More

    Frequency, duration and cause of ventilator alarms on a neonatal intensive care unit.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 27. Epub 2017 Oct 27.
    Neonatal Services, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Objective: To investigate the frequency and cause of neonatal ventilator alarms. Neonatal ventilators frequently alarm and also disturb babies, parents and nurses. If frequent they may cause alarm fatigue and be ignored. Read More

    Validity of neurodevelopmental outcomes of children born very preterm assessed during routine clinical follow-up in England.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 27. Epub 2017 Oct 27.
    Section of Neonatal Medicine, Department of Medicine, Chelsea and Westminster Hospital Campus, Imperial College London, London, UK.
    Objective: To determine the validity of assessing and recording the neurodevelopmental outcome of very preterm infants during routine clinical follow-up in England.

    Design: Children born <30 weeks gestation, attending routine clinical follow-up at post-term ages 20-28 months, were recruited. Data on neurodevelopmental outcomes were recorded by the reviewing clinician in a standardised format in the child's electronic patient record, based on a set of key questions designed to be used without formal training or developmental testing. Read More

    Variation in hospital mortality in an Australian neonatal intensive care unit network.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 26. Epub 2017 Oct 26.
    Research School of Population Health and Medical School, Australian National University, Acton, Australian Capital Territory, Australia.
    Background: Studying centre-to-centre (CTC) variation in mortality rates is important because inferences about quality of care can be made permitting changes in practice to improve outcomes. However, comparisons between hospitals can be misleading unless there is adjustment for population characteristics and severity of illness.

    Objective: We sought to report the risk-adjusted CTC variation in mortality among preterm infants born <32 weeks and admitted to all eight tertiary neonatal intensive care units (NICUs) in the New South Wales and the Australian Capital Territory Neonatal Network (NICUS), Australia. Read More

    2% chlorhexidine-70% isopropyl alcohol versus 10% povidone-iodine for insertion site cleaning before central line insertion in preterm infants: a randomised trial.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 26. Epub 2017 Oct 26.
    Department of Neonatology, The National Maternity Hospital, Dublin, Ireland.
    Objective: To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants.

    Design: Randomised controlled trial.

    Setting: Two neonatal intensive care units (NICUs). Read More

    Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 26. Epub 2017 Oct 26.
    Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.
    Objective: To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK.

    Design: Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014.

    Setting: 30 neonatal units in the UK. Read More

    Transcatheter occlusion of the patent ductus arteriosus in premature infants weighing less than 1200 g.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 24. Epub 2017 Oct 24.
    Department of Pediatric Cardiology, CHU de Grenoble France, Grenoble, France.
    Objectives: Over the last few decades different strategies have been proposed to treat persistent ductal patency in premature infants. The advent of the Amplatzer Duct Occluder II Additional Size (ADOIIAS) provided the potential to close the patent ductus arteriosus (PDA). Opinions differ on the significance and treatment of PDA in premature neonates. Read More

    Laryngeal closure impedes non-invasive ventilation at birth.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 20. Epub 2017 Oct 20.
    The Ritchie Centre, Hudson Institute for Medical Research, Melbourne, Clayton, Australia.
    Background: Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in the delivery room. While airway obstruction is thought to be the main problem, the site of obstruction is unknown. We investigated whether closure of the larynx and epiglottis is a major site of airway obstruction. Read More

    Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluation.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 7. Epub 2017 Oct 7.
    Centre for the Developing Brain, School of Bioengineering and Imaging Sciences, King's College London, and Evelina London Children's Hospital, London, UK.
    Background: We tested the hypothesis that routine MRI would improve the care and well-being of preterm infants and their families.

    Design: Parallel-group randomised trial (1.1 allocation; intention-to-treat) with nested diagnostic and cost evaluations (EudraCT 2009-011602-42). Read More

    Chest compression during sustained inflation versus 3:1 chest compression:ventilation ratio during neonatal cardiopulmonary resuscitation: a randomised feasibility trial.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 7. Epub 2017 Oct 7.
    Neonatal Research Unit, Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Alberta Health Services, Edmonoton, Canada.
    Background: Current neonatal resuscitation guidelines recommend 3:1 compression:ventilation (C:V) ratio. Recently, animal studies reported that continuous chest compressions (CC) during a sustained inflation (SI) significantly improved return of spontaneous circulation (ROSC). The approach of CC during SI (CC+SI) has not been examined in the delivery room during neonatal resuscitation. Read More

    Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants.
    Arch Dis Child Fetal Neonatal Ed 2017 Oct 7. Epub 2017 Oct 7.
    Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain.
    Objective: To determine the association between SpO2 at 5 min and preterm infant outcomes.

    Design: Data from 768 infants <32 weeks gestation from 8 randomised controlled trials (RCTs) of lower (≤0.3) versus higher (≥0. Read More

    Sensory exposure of neonates in single-room environments (SENSE): an observational study of light.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 27. Epub 2017 Sep 27.
    School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, QLD, Australia.
    Objectives: To measure the internal and external light exposure of incubators and open cots in an Australian single-room configured neonatal unit and compare findings to current recommendations.

    Methods: Light meters were placed in the internal and external environment of incubators and open cots within occupied single rooms in a tertiary-level neonatal unit between 15 September and 28 October 2015. Data were recorded in one-second increments over a minimum of 48 hours per room. Read More

    Effect of a smaller target range on the compliance in targeting and distribution of oxygen saturation in preterm infants.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 26. Epub 2017 Sep 26.
    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
    Background: Following recent recommendations, the oxygen saturation (SpO2) target range for preterm infants in our nursery was narrowed towards the higher end from 85%-95% to 90%-95%. We determined the effect of narrowing the SpO2 target range on the compliance in target range and distribution of SpO2 in preterm infants.

    Methods: Before and after changing the target range from 85%-95% to 90%-95%, infants <30 weeks of gestation receiving oxygen were compared during their admission on the neonatal intensive care unit. Read More

    Extracorporeal membrane oxygenation for neonatal collapse caused by enterovirus myocarditis.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 29. Epub 2017 Sep 29.
    Paediatric Intensive Care Unit, The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.
    Objective: To describe the effect of extracorporeal membrane oxygenation (ECMO) on survival and cardiac outcome of neonates with myocardial failure secondary to severe enterovirus (EV) myocarditis.

    Design: Retrospective case series.

    Setting: A 15-bed cardiac paediatric intensive care unit (ICU). Read More

    Parental experience of interaction with healthcare professionals during their infant's stay in the neonatal intensive care unit.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 29. Epub 2017 Sep 29.
    UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
    Objective: To explore the experiences of parents of infants admitted to the neonatal intensive care unit towards interaction with healthcare professionals during their infants critical care.

    Design: Semi-structured interviews were conducted with parents of critically ill infants admitted to neonatal intensive care and prospectively enrolled in a study of communication in critical care decision making. Interviews were transcribed verbatim and uploaded into NVivo V. Read More

    Respiratory adaptation in term infants following elective caesarean section.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 29. Epub 2017 Sep 29.
    Department of Paediatrics and Child Health, Cork University Maternity Hospital, Cork, Ireland.
    Objective: To determine respiratory rate (RR), tidal volume (TV) and end-tidal carbon dioxide (EtCO2) values in full-term infants immediately after caesarean section, and to assess whether infants that develop transient tachypnoea of the newborn (TTN) follow the same physiological patterns.

    Design And Patients: A Respironics NM3 Monitor (Philips, Netherlands) continuously measured RR, TV and EtCO2 for 7 min in infants >37 weeks' gestation following elective caesarean section (ECS). Monitoring was repeated at 2 hours of age for 2 min. Read More

    Always a burden? Healthcare providers' perspectives on moral distress.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 29. Epub 2017 Sep 29.
    Departement of Pediatrics, Division of Neonatology, Clinical Ethics Unit, Palliative Care Unit, Unité de Recherche en Éthique Clinique et Partenariat Famille, CHU Ste-Justine, Montreal, Quebec, Canada.
    Background: Current conceptualisations of moral distress largely portray a negative phenomenon that leads to burnout, reduced job satisfaction and poor patient care.

    Objective: To explore clinical experiences, perspectives and perceptions of moral distress in neonatology.

    Design: An anonymous questionnaire was distributed to medical and nursing providers within two tertiary level neonatal intensive care units (NICUs)-one surgical and one perinatal-seeking their understanding of the term and their experience of it. Read More

    Mode of delivery and outcomes of infants with gastroschisis: a meta-analysis of observational studies.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 28. Epub 2017 Sep 28.
    Medical School, College of Medicine, Biology & Environment, Australian National University, Canberra, Australian Capital Territory, Australia.
    Background: There is controversy among the literature for electing caesarean section (CS) delivery for infants with gastroschisis in an attempt to reduce mortality and morbidity.

    Objective: This meta-analysis investigates whether there is enough evidence to support CS delivery over vaginal delivery.

    Data Sources: We conducted our search in April 2017. Read More

    Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 23. Epub 2017 Sep 23.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA.
    Objective: Screening criteria for neonatal encephalopathy remain a complex combination of subjective and objective criteria. We examine the utility of universal cord blood gas testing and mandatory encephalopathy evaluation for infants with pH ≤7.10 on umbilical cord arterial blood gas (cABG) as a single screening measure for timely identification of moderate/severe encephalopathy. Read More

    Therapeutic hypothermia in mild neonatal encephalopathy: a national survey of practice in the UK.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 23. Epub 2017 Sep 23.
    Centre for Perinatal Neuroscience, Department of Paediatrics, Imperial College London, London, London, UK.
    Although major cooling trials (and subsequent guidelines) excluded babies with mild encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants. We report a national survey on current cooling practices for babies with mild encephalopathy in the UK. From 74 neonatal units contacted, 68 were cooling centres. Read More

    Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 21. Epub 2017 Sep 21.
    Centre for Perinatal Neuroscience, Imperial College London, London, UK.
    We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5-13) due to rapid clinical improvement. Read More

    Randomised trial of cord clamping and initial stabilisation at very preterm birth.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 18. Epub 2017 Sep 18.
    Neonatal Unit, Leicester Royal Infirmary, Leicester, UK.
    Objectives: For very preterm births, to compare alternative policies for umbilical cord clamping and immediate neonatal care.

    Design: Parallel group randomised (1:1) trial, using sealed opaque numbered envelopes.

    Setting: Eight UK tertiary maternity units. Read More

    Non-invasive high-frequency oscillatory ventilation in preterm infants: a randomised controlled cross-over trial.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 16. Epub 2017 Sep 16.
    Department of Neonatology, Center for Pediatrics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Objective: Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO2 partial pressure (pCO2) in premature infants more effectively than non-invasive continuous positive airway pressure (nCPAP).

    Design: Non-blinded prospective randomised controlled cross-over study. Read More

    Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006-2015: a population-based analysis.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 15. Epub 2017 Sep 15.
    Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
    Background: Retinopathy of prematurity (ROP) is a severe complication of preterm birth and can lead to severe visual impairment or even blindness if untreated. The incidence of ROP requiring treatment is increasing in some developed countries in conjunction with higher survival rates at the lower end of gestational age (GA).

    Material And Methods: The incidence of ROP and severe ROP (sROP) requiring treatment in Switzerland was analysed using the SwissNeoNet registry. Read More

    Randomised trial of estimating oral endotracheal tube insertion depth in newborns using weight or vocal cord guide.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 7. Epub 2017 Sep 7.
    Neonatal Department, National Maternity Hospital, Dublin, Ireland.
    Background: When intubating newborns, clinicians aim to position the endotracheal tube (ETT) tip in the midtrachea. The depth to which ETTs should be inserted is often estimated using the infant's weight. ETTs are frequently incorrectly positioned in newborns, most often inserted too far. Read More

    Survival of very preterm infants admitted to neonatal care in England 2008-2014: time trends and regional variation.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 7. Epub 2017 Sep 7.
    Section of Neonatal Medicine, Department of Medicine, Imperial College London, London, UK.
    Objective: To analyse survival trends and regional variation for very preterm infants admitted to neonatal care.

    Setting: All neonatal units in England.

    Patients: Infants born at 22(+0)-31(+6) weeks(+days)gestational age (GA) over 2008-2014 and admitted to neonatal care; published data for admitted infants 22(+0)-25(+6) weeks(+days) GA in 1995 and 2006, and for live births at 22(+0)-31(+6) weeks(+days) GA in 2013. Read More

    Severe acquired subglottic stenosis in neonatal intensive care graduates: a case-control study.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 2. Epub 2017 Sep 2.
    Biostatistics and Research Design Unit, School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
    Objective: To analyse current incidence and risk factors associated with severe acquired subglottic stenosis (SASGS) requiring surgical intervention in neonates.

    Design: Retrospective case-control study.

    Setting: Sole tertiary children's hospital. Read More

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