4,119 results match your criteria Archives of Dermatological Research[Journal]


Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march.

Arch Dermatol Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age). Read More

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http://dx.doi.org/10.1007/s00403-019-01895-zDOI Listing
February 2019

Meta-analysis and prioritization of human skin pigmentation-associated GWAS-SNPs using ENCODE data-based web-tools.

Arch Dermatol Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Genetics, University of Calcutta, Kolkata, India.

Skin pigmentation in human is a complex trait, which varies widely, both within and between human populations. The exact players governing the trait of skin pigmentation remain elusive till date. Various Genome Wide Association Studies (GWAS) have shown the association of different genomic variants with normal human skin pigmentation, often indicating genes with no direct implications in melanin biosynthesis or distribution. Read More

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http://dx.doi.org/10.1007/s00403-019-01891-3DOI Listing
February 2019

Treponema pallidum induces the activation of endothelial cells via macrophage-derived exosomes.

Arch Dermatol Res 2019 Feb 2. Epub 2019 Feb 2.

Department of Dermatology, Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, 214002, China.

Recent studies have shown that exosomes play a role in pathogenesis and in the treatment of inflammatory diseases and tumours. We explored the effects of Treponema pallidum-induced macrophage-derived exosomes on vascular endothelial cells to determine whether they are involved in the pathogenesis of syphilis. A syphilis infection model was established using rabbits to harvest T. Read More

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http://link.springer.com/10.1007/s00403-018-01888-4
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http://dx.doi.org/10.1007/s00403-018-01888-4DOI Listing
February 2019
7 Reads

Ameliorative effects of green tea extract from tannase digests on house dust mite antigen-induced atopic dermatitis-like lesions in NC/Nga mice.

Arch Dermatol Res 2019 Jan 7. Epub 2019 Jan 7.

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 54538, South Korea.

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which is affected by several factors. Anti-histamines, steroids, and immunosuppressive agents have been used for the treatment of AD. However, many studies have reported that long-term use and abuse of these drugs causes many side effects. Read More

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http://dx.doi.org/10.1007/s00403-018-01886-6DOI Listing
January 2019
1 Read

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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http://link.springer.com/10.1007/s00403-018-1885-x
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http://dx.doi.org/10.1007/s00403-018-1885-xDOI Listing
December 2018
9 Reads

Comparing early and late treatments with rituximab in pemphigus vulgaris: which one is better?

Arch Dermatol Res 2019 Jan 1;311(1):63-69. Epub 2018 Dec 1.

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.

During the last decade, successfully treatment of patients diagnosed with pemphigus vulgaris (PV) with rituximab (RTX) was reported by several authors. The present study has been designed to compare the clinical outcomes and RTX-related side effects between the two groups of early treated (≤ 6 months) and lately treated PV (> 6 months) patients with RTX. We did a retrospective study between Oct 2014 and Jun 2016 to compare the short-term efficacy and safety of RTX in PV diagnosed patients. Read More

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http://link.springer.com/10.1007/s00403-018-1881-1
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http://dx.doi.org/10.1007/s00403-018-1881-1DOI Listing
January 2019
12 Reads

Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model.

Arch Dermatol Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyunggi-do, 16419, Republic of Korea.

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. Read More

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http://dx.doi.org/10.1007/s00403-018-1883-zDOI Listing
November 2018
5 Reads

Downregulation of aquaporin 3 in bullous pemphigoid patients.

Arch Dermatol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al Manial, Cairo, 11956, Egypt.

Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Read More

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http://dx.doi.org/10.1007/s00403-018-1884-yDOI Listing
December 2018
6 Reads

Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development.

Arch Dermatol Res 2019 Jan 3;311(1):71-82. Epub 2018 Dec 3.

Department of Dermatology, Kyorin University School of Medicine, 6-20-2, Shinkawa Mitaka, Tokyo, 181-8611, Japan.

No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Read More

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http://dx.doi.org/10.1007/s00403-018-1882-0DOI Listing
January 2019
3 Reads

CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration.

Arch Dermatol Res 2019 Jan 27;311(1):55-62. Epub 2018 Nov 27.

Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, Japan.

Melanocyte stem cells (McSCs) are localized in the bulge region of hair follicles and supply melanocytes, which determine hair color by synthesizing melanin. Ectopic differentiation of McSCs, which are usually undifferentiated in the bulge region, causes depletion of McSCs and results in hair graying. Therefore, to prevent hair graying, it is essential to maintain McSCs in the bulge region, but the mechanism of McSC maintenance remains unclear. Read More

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http://dx.doi.org/10.1007/s00403-018-1880-2DOI Listing
January 2019
2 Reads

The role of PI3K/AKT/FOXO signaling in psoriasis.

Arch Dermatol Res 2018 Nov 27. Epub 2018 Nov 27.

Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.

Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathway play a central role in multiple cellular functions such as cell proliferation and survival. The forkhead box O (FOXO) transcription factors are negatively regulated by the PI3K/AKT signaling pathway and considered to have inhibitory effect on cell proliferation. Psoriasis is a multifactorial disease with a strong genetic background and characterized by hyperproliferative keratinocyte. Read More

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http://dx.doi.org/10.1007/s00403-018-1879-8DOI Listing
November 2018
2 Reads

Podoplanin suppresses the cell adhesion of epidermal keratinocytes via functional regulation of β1-integrin.

Arch Dermatol Res 2019 Jan 20;311(1):45-53. Epub 2018 Nov 20.

Department of Dermatology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan.

Epidermal stem cells adhere more efficiently to the extracellular matrix (ECM) than the less adhesive differentiating cells due to their high expression of cell adhesion molecules including β1-integrin. Podoplanin is majorly expressed in the markedly proliferative and differentiating basal cells of the wounded and psoriatic epidermis. This study was designed to reveal podoplanin's function in human epidermal keratinocytes (HEK) focusing on its interaction with β1-integrin. Read More

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http://dx.doi.org/10.1007/s00403-018-1878-9DOI Listing
January 2019
2 Reads

Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma.

Arch Dermatol Res 2019 Jan 20;311(1):37-43. Epub 2018 Nov 20.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

The cellular origin of Merkel cell carcinoma (MCC) is controversial. We previously hypothesized that MCC originates from hair follicle stem cells or Merkel cell (MC) progenitors residing within the hair follicle bulge. Examination of three cases of combined MCC led to the unexpected discovery that numerous keratin 20 (CK20)-positive MCs within the squamous cell carcinoma (SCC) component of combined MCC appeared morphologically normal with dendritic and oval shapes. Read More

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http://dx.doi.org/10.1007/s00403-018-1877-xDOI Listing
January 2019
7 Reads

A randomized placebo-controlled single-center pilot study of the safety and efficacy of apremilast in subjects with moderate-to-severe alopecia areata.

Arch Dermatol Res 2019 Jan 11;311(1):29-36. Epub 2018 Nov 11.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alopecia areata (AA) is a common autoimmune disease that results in non-scarring hair loss. AA pathogenesis is thought to involve multiple inflammatory cytokines. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that reduces pro-inflammatory cytokine production. Read More

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http://dx.doi.org/10.1007/s00403-018-1876-yDOI Listing
January 2019
4 Reads

Gene expression analysis of antimony resistance in Leishmania tropica using quantitative real-time PCR focused on genes involved in trypanothione metabolism and drug transport.

Arch Dermatol Res 2019 Jan 2;311(1):9-17. Epub 2018 Nov 2.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Pentavalent antimonials remain the treatment of choice for all the clinical forms of leishmaniasis. The increasing rates of antimony resistance are becoming a serious health problem in treatment of anthroponotic cutaneous leishmaniasis (ACL). Accordingly, unraveling molecular markers is crucial for improving medication strategies and monitoring of drug-resistant parasites. Read More

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http://link.springer.com/10.1007/s00403-018-1872-2
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http://dx.doi.org/10.1007/s00403-018-1872-2DOI Listing
January 2019
2 Reads

Mortality and risk factors among Israeli bullous pemphigoid patients.

Arch Dermatol Res 2019 Jan 31;311(1):19-27. Epub 2018 Oct 31.

Department of Dermatology, Emek Medical Center, Afula, Israel.

There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Read More

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http://link.springer.com/10.1007/s00403-018-1875-z
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http://dx.doi.org/10.1007/s00403-018-1875-zDOI Listing
January 2019
6 Reads

Small intestinal bacterial overgrowth in systemic sclerosis: a review of the literature.

Arch Dermatol Res 2019 Jan 31;311(1):1-8. Epub 2018 Oct 31.

Chair and Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland.

Systemic sclerosis (SSc) is a chronic, connective tissue disease with an autoimmune pattern characterized by inflammation, fibrosis and microcirculation changes leading to internal organs malfunctions. Recently, the presence of uncharacteristic gastrointestinal symptoms in the course of SSc has been underlined. The possible cause of such clinical presentation is the small intestinal bacterial overgrowth (SIBO). Read More

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http://link.springer.com/10.1007/s00403-018-1874-0
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http://dx.doi.org/10.1007/s00403-018-1874-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326989PMC
January 2019
4 Reads

Reconstructed human keloid models show heterogeneity within keloid scars.

Arch Dermatol Res 2018 Dec 28;310(10):815-826. Epub 2018 Oct 28.

Department of Molecular Cell Biology and Immunology, O|2 Lab Building, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions. Read More

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http://dx.doi.org/10.1007/s00403-018-1873-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244653PMC
December 2018
1 Read

Benefits of a membership in a psoriasis patient organisation: a quasi-experimental longitudinal study.

Arch Dermatol Res 2018 Dec 22;310(10):807-813. Epub 2018 Oct 22.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

Background And Objectives: Patient organisations play an important role in supporting patients with chronic diseases and allow information transfer beyond professional care structures. Until now, only few studies have investigated the benefits of a dermatological patient organisation. In this study, potential benefits of joining the German Psoriasis Association (Deutscher Psoriasis Bund e. Read More

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http://link.springer.com/10.1007/s00403-018-1869-x
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http://dx.doi.org/10.1007/s00403-018-1869-xDOI Listing
December 2018
9 Reads

Topical treatment with the bacterium-derived c-Met agonist InlB/15 accelerates healing in the abrasion wound mouse model.

Arch Dermatol Res 2018 Dec 10;310(10):849-856. Epub 2018 Oct 10.

Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.

Studies of factors affecting wound-healing rates are encouraged by a critical need for new treatments to manage an increasing burden of non-healing wounds. The InlB protein produced by the Gram-positive bacterium Listeria monocytogenes is an agonist of the tyrosine kinase receptor c-Met and a functional analog of the hepatocyte growth factor (HGF), which is a mammalian ligand of c-Met. The recombinant InlB protein, which is the c-Met-binding InlB domain (amino acids 31-321), was cloned from the L. Read More

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http://link.springer.com/10.1007/s00403-018-1870-4
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http://dx.doi.org/10.1007/s00403-018-1870-4DOI Listing
December 2018
5 Reads

Inflammatory reaction, clinical efficacy, and safety of bacterial cellulose wound dressing containing silk sericin and polyhexamethylene biguanide for wound treatment.

Arch Dermatol Res 2018 Dec 9;310(10):795-805. Epub 2018 Oct 9.

Bioactive Resources for Innovative Clinical Applications Research Unit, Chulalongkorn University, Bangkok, Thailand.

Bacterial cellulose wound dressings containing silk sericin and PHMB (BCSP) were developed in our previous studies. It had good physical properties, efficacy, and safety. For further use as a medical material, this dressing was investigated for its efficacy and safety in split-thickness skin graft (STSG) donor-site wound treatment compared to Bactigras® (control). Read More

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http://link.springer.com/10.1007/s00403-018-1871-3
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http://dx.doi.org/10.1007/s00403-018-1871-3DOI Listing
December 2018
4 Reads

Visfatin and insulin levels and cigarette smoking are independent risk factors for hidradenitis suppurativa: a case-control study.

Arch Dermatol Res 2018 Dec 6;310(10):785-793. Epub 2018 Oct 6.

Department of Medical Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS. Read More

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http://link.springer.com/10.1007/s00403-018-1867-z
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http://dx.doi.org/10.1007/s00403-018-1867-zDOI Listing
December 2018
8 Reads

Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice.

Arch Dermatol Res 2018 Dec 5;310(10):843-848. Epub 2018 Oct 5.

Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.

Many hair loss disorders, including non-scaring alopecia, are caused by the arrest of hair follicles at the telogen phase, and the failure to enter the growth phase. Several studies report the efficacy of tofacitinib in promoting hair growth, by mechanisms not precisely known. The aim of this study was to identify other mechanisms by which tofacitinib, applied topically, promotes hair growth. Read More

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http://link.springer.com/10.1007/s00403-018-1868-y
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http://dx.doi.org/10.1007/s00403-018-1868-yDOI Listing
December 2018
2 Reads

Systematic review of mobile phone-based teledermatology.

Arch Dermatol Res 2018 Nov 24;310(9):675-689. Epub 2018 Sep 24.

Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.

Teledermatology is an expanding field within dermatology that has grown and become more clinically accepted by both patients and doctors. With approximately 260 million mobile phone users in the US and 4-6 billion worldwide with access to mobile phones, teledermatology serves as a potentially useful tool for diagnosis and management (Samkange-Zeeb and Blettner in Emerg Health Threats J, https://doi.org/10. Read More

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http://link.springer.com/10.1007/s00403-018-1862-4
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http://dx.doi.org/10.1007/s00403-018-1862-4DOI Listing
November 2018
8 Reads

Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?

Arch Dermatol Res 2018 Dec 22;310(10):833-841. Epub 2018 Sep 22.

Centre for Dermatology Research, University of Manchester, Manchester, UK.

Chronic wounds remain a major unmet healthcare challenge, associated with substantial morbidity and economic costs. Therefore, novel treatment strategies and therapeutic approaches need to be urgently developed. Yet, despite the increasingly recognized importance of neurohormonal signaling in skin physiology, the neuroendocrine regulation of cutaneous wound healing has received surprisingly little attention. Read More

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http://dx.doi.org/10.1007/s00403-018-1864-2DOI Listing
December 2018
2 Reads

Melanoma-prone families: new evidence of distinctive clinical and histological features of melanomas in CDKN2A mutation carriers.

Arch Dermatol Res 2018 Sep 15. Epub 2018 Sep 15.

Department of Health Sciences, A. Avogadro University of Eastern Piedmont, Corso Mazzini 18, 28100, Novara, Italy.

Germline mutations on the CDKN2A gene, the most important known genetic factors associated with cutaneous melanomas (CMs), predispose carriers to multiple primary CMs (MPMs) with higher frequency and younger onset compared to non-carriers. Most of the largest published studies concerning clinical and histological characteristics of CMs with CDKN2A mutation carriers did not specify if the described CMs are first or subsequent to the first, and they used sporadic CMs from non-genotyped patients as controls. We conducted a single-centre observational study to compare clinical and histological CM features of 32 unrelated carriers (MUT) of 5 germline CDKN2A mutations (one of which was never previously described) compared to 100 genotyped wild-type (WT) patients. Read More

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http://dx.doi.org/10.1007/s00403-018-1866-0DOI Listing
September 2018
4 Reads

Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate.

Arch Dermatol Res 2018 Sep 12. Epub 2018 Sep 12.

Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, Kiel, Germany.

The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of these receptors and their reaction to SB in psoriasis. Read More

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http://dx.doi.org/10.1007/s00403-018-1865-1DOI Listing
September 2018
3 Reads

The role of TrkA in the promoting wounding-healing effect of CD271 on epidermal stem cells.

Arch Dermatol Res 2018 Sep 12. Epub 2018 Sep 12.

Department of Burns and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250000, Shandong, China.

CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exact role of TrkA combined with CD271 in eSCs during skin wound closure is still unclear. Read More

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http://link.springer.com/10.1007/s00403-018-1863-3
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http://dx.doi.org/10.1007/s00403-018-1863-3DOI Listing
September 2018
8 Reads

Age-related and seasonal changes in covalently bound ceramide content in forearm stratum corneum of Japanese subjects: determination of molecular species of ceramides.

Arch Dermatol Res 2018 Nov 4;310(9):729-735. Epub 2018 Sep 4.

Department of Dermatology, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

The stratum corneum (SC) consists of corneocytes surrounded by a neutral lipid-enriched intercellular matrix. Ceramides represent approximately 50% of intercellular lipids, and play important roles in retaining epidermal water. The SC also contains covalently bound ceramides, which are thought to play a crucial role in the formation of lamellar structures, and are involved in maintaining skin barrier function. Read More

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http://dx.doi.org/10.1007/s00403-018-1859-zDOI Listing
November 2018
5 Reads

Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis.

Arch Dermatol Res 2018 Nov 31;310(9):711-728. Epub 2018 Aug 31.

Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.

Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2. Read More

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http://dx.doi.org/10.1007/s00403-018-1858-0DOI Listing
November 2018
4 Reads

Complex segregation analysis of facial melasma in Brazil: evidence for a genetic susceptibility with a dominant pattern of segregation.

Arch Dermatol Res 2018 Dec 30;310(10):827-831. Epub 2018 Aug 30.

Departamento de Dermatologia e Radioterapia, SN, FMB-Unesp, Campus de Rubião Jr., Botucatu, SP, CEP 18618-000, Brazil.

Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40-60%) suggests a genetic predisposition to the disease. Read More

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http://dx.doi.org/10.1007/s00403-018-1861-5DOI Listing
December 2018
2 Reads

Expression of inflammatory and fibrogenetic markers in acne hypertrophic scar formation: focusing on role of TGF-β and IGF-1R.

Arch Dermatol Res 2018 Oct 29;310(8):665-673. Epub 2018 Aug 29.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.

Acne vulgaris is a universal skin disease and it may leave a scar when the original skin lesion disappears. These scars can cause cosmetic problems and psychological burden, leading to poor quality of life of patients. Acne scars are classified into atrophic scars and hypertrophic scars. Read More

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http://link.springer.com/10.1007/s00403-018-1856-2
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http://dx.doi.org/10.1007/s00403-018-1856-2DOI Listing
October 2018
16 Reads

Achieving international consensus on the assessment of psoriatic arthritis in psoriasis clinical trials: an International Dermatology Outcome Measures (IDEOM) initiative.

Arch Dermatol Res 2018 Nov 25;310(9):701-710. Epub 2018 Aug 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Psoriatic arthritis (PsA) is rarely assessed in psoriasis randomized controlled trials (RCT); thus, the effect of psoriasis therapy on PsA is unknown. The International Dermatology Outcome Measures (IDEOM) has included "PsA Symptoms" as part of the core domains to be measured in psoriasis RCT. This study aimed to achieve consensus about screening for PsA and how to measure for "PsA Symptoms" in psoriasis RCT. Read More

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http://link.springer.com/10.1007/s00403-018-1855-3
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http://dx.doi.org/10.1007/s00403-018-1855-3DOI Listing
November 2018
10 Reads
2.270 Impact Factor

A comprehensive in vivo study of Caucasian facial skin parameters on 442 women.

Arch Dermatol Res 2018 Nov 30;310(9):691-699. Epub 2018 Aug 30.

Contipro a.s., Dolní Dobrouč 401, 56102, Dolní Dobrouč, Czech Republic.

Generally, skin properties are highly specific for each individual depending on various factors such as genetic predisposition, age, gender, body region, health and lifestyle. In this study, we measured various skin parameters on forehead, temple and cheek of 442 Caucasian women between 23 and 63 years, and evaluated differences between these facial regions and also the relationship between skin parameters and age of the volunteers. We measured transepidermal water loss (TEWL), stratum corneum hydration, skin gloss, melanin level, individual typology angle (ITA), erythema, sebum level and elasticity (R7). Read More

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http://dx.doi.org/10.1007/s00403-018-1860-6DOI Listing
November 2018
1 Read

The investigation of the relationships of demodex density with inflammatory response and oxidative stress in rosacea.

Arch Dermatol Res 2018 Nov 27;310(9):759-767. Epub 2018 Aug 27.

Department of Dermatology, Ağrı State Hospital, Ağrı, Turkey.

The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis. Forty patients with rosacea and 40 age-, sex-, and skin phenotype-matched healthy volunteers were included in the study. Read More

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http://dx.doi.org/10.1007/s00403-018-1857-1DOI Listing
November 2018
6 Reads

Efficacy and safety of secukinumab treatment in adults with extensive alopecia areata.

Arch Dermatol Res 2018 Oct 18;310(8):607-614. Epub 2018 Aug 18.

Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY, USA.

Alopecia areata (AA) is a common form of non-scarring hair loss. The pathogenesis of AA is believed to involve multiple inflammatory cytokines, including possibly IL-17A. To assess the efficacy and safety of the IL-17A antagonist secukinumab in AA, we conducted a double-blinded, randomized prospective pilot study in which 11 subjects were treated with either secukinumab (n = 7) or placebo (n = 4) subcutaneously at weeks 0, 1, 2, 3, 4 and every 4 weeks thereafter until (inclusive of) week 20. Read More

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http://link.springer.com/10.1007/s00403-018-1853-5
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http://dx.doi.org/10.1007/s00403-018-1853-5DOI Listing
October 2018
42 Reads

Caffeine delivery in porcine skin: a confocal Raman study.

Arch Dermatol Res 2018 Oct 13;310(8):657-664. Epub 2018 Aug 13.

Department of Chemicals and Surfactants Technology, Advanced Chemical Institute of Catalonia, (IQAC-CSIC), Jordi Girona 18-26, 08034, Barcelona, Spain.

Confocal Raman microscopy is a novel optical method for studies of pro-drug and drug delivery. This method is a promising technique that enables non-destructive measurement of the permeation profile through skin layers. Peaks of compounds are usually normalised to skin peaks (amino-acid and amide I) for semi-quantitative evaluation. Read More

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http://dx.doi.org/10.1007/s00403-018-1854-4DOI Listing
October 2018
8 Reads

Heme oxygenase and iron status in exosomes of psoriasis patients.

Arch Dermatol Res 2018 Oct 13;310(8):651-656. Epub 2018 Aug 13.

Clinical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

Psoriasis is an autoimmune skin disease characterized by hyperproliferation of keratinocytes due to interplay between keratinocytes and immune cells. Iron status plays an important role in modifying the function of the immune system. Heme oxygenase (HO), heme-degrading enzyme, plays important role in protective response to oxidative cellular stress. Read More

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http://dx.doi.org/10.1007/s00403-018-1852-6DOI Listing
October 2018
13 Reads
2.270 Impact Factor

Different Trypanosoma cruzi calreticulin domains mediate migration and proliferation of fibroblasts in vitro and skin wound healing in vivo.

Arch Dermatol Res 2018 Oct 11;310(8):639-650. Epub 2018 Aug 11.

Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

Calreticulin is an endoplasmic reticulum-resident, calcium-binding, stress-produced, chaperone protein that serves multiple functions and is widely distributed in eukaryotic cells. Exogenously applied recombinant calreticulin solution, markedly enhanced the rate and quality of skin wound healing. These modulatory effects are more efficient than commercially available topic platelet-derived growth factor ointments (Regranex). Read More

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http://dx.doi.org/10.1007/s00403-018-1851-7DOI Listing
October 2018
3 Reads

Glucosamine abrogates the stem cell factor + endothelin-1-induced stimulation of melanogenesis via a deficiency in MITF expression due to the proteolytic degradation of CREB in human melanocytes.

Arch Dermatol Res 2018 Oct 25;310(8):625-637. Epub 2018 Jul 25.

Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.

We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of GlcN using normal human melanocytes (NHMs) in culture. The SE-stimulated gene (12 h) and protein (24 h) expression levels of melanocyte-specific proteins (at the indicated times post-stimulation) were significantly abrogated by pretreatment with GlcN for 72 h. Read More

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http://dx.doi.org/10.1007/s00403-018-1850-8DOI Listing
October 2018
2 Reads

LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts.

Arch Dermatol Res 2018 Oct 25;310(8):615-623. Epub 2018 Jul 25.

Department of Dermato-venereology, the Second Hospital of Shandong University, 247 Beiyuan Dajie Street, Jinan, 250033, Shandong, China.

Hypertrophic scars (HS) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly collagen. They usually occur after dermal injury in genetically susceptible individuals and cause both physical and psychological distress for the affected individuals. Transforming growth factor-β1 (TGF-β1) is known to mediate wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation. Read More

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http://dx.doi.org/10.1007/s00403-018-1849-1DOI Listing
October 2018
5 Reads

Linoleate-enriched diet increases both linoleic acid esterified to omega hydroxy very long chain fatty acids and free ceramides of canine stratum corneum without effect on protein-bound ceramides and skin barrier function.

Arch Dermatol Res 2018 Jul 11. Epub 2018 Jul 11.

LBTM1 "Fundamental, clinical and therapeutic aspects of the skin barrier function", University of Lyon-1, Lyon, France.

Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was studied by feeding two groups of five dogs differential amounts of linoleic acid (LA) for three months. SC was harvested by tape stripping and lipids were analyzed by thin-layer chromatography and mass spectrometry. Read More

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http://dx.doi.org/10.1007/s00403-018-1845-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096565PMC
July 2018
19 Reads

Phenotype variability in tumor disorders of the skin appendages associated with mutations in the CYLD gene.

Arch Dermatol Res 2018 Sep 4;310(7):599-606. Epub 2018 Jul 4.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Mutations in the tumor suppressor gene CYLD underlie phenotypically heterogeneous hereditary tumor disorders of the skin appendages. These diseases are inherited autosomal dominantly and include Brooke-Spiegler syndrome (BSS; OMIM 605041), familial cylindromatosis (FC; OMIM 132700) and multiple familial trichoepithelioma (MFT; OMIM 601606). Clinically, cylindromas, trichoepitheliomas and spiradenomas can be found in affected individuals. Read More

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http://dx.doi.org/10.1007/s00403-018-1848-2DOI Listing
September 2018
5 Reads

Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.

Arch Dermatol Res 2018 Aug 9;310(6):515-522. Epub 2018 Jun 9.

Department of Dermatology and Venereology, Medical University of Lodz, Plac Hallera 1, 90-647, Lodz, Poland.

Bullous pemphigoid (BP) constitutes the most prevalent disease in the group of bullous dermatoses with the autoimmune background. Some authors suggest that certain cytokines (IL-2, IFN-γ) may be transported by P-glycoprotein (P-gp), the product of the ABCB1 gene. ABCB1 polymorphism might affect not only the effectiveness of treatment with drugs that are P-gp substrates but also contribute to the development of diseases, including BP. Read More

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http://dx.doi.org/10.1007/s00403-018-1842-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060767PMC
August 2018
4 Reads

How to weight patient-relevant treatment goals for assessing treatment benefit in psoriasis: preference elicitation methods vs. rating scales.

Arch Dermatol Res 2018 Jun 23. Epub 2018 Jun 23.

German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

In psoriasis, several patient-relevant treatment goals must be met to be able to consider a treatment beneficial. To assess treatment benefit, the validated questionnaire Patient Benefit Index (PBI) can be used. Its global score summarizes the degree of patient-relevant treatment goals achieved after treatment, weighted by their individual importance on rating scales. Read More

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http://link.springer.com/10.1007/s00403-018-1846-4
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http://dx.doi.org/10.1007/s00403-018-1846-4DOI Listing
June 2018
8 Reads

Identification of a novel mutation in the mechanoreceptor-encoding gene CXCR1 in patients with keloid.

Arch Dermatol Res 2018 Jun 21. Epub 2018 Jun 21.

The Department of Dermatology, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

Keloids are skin fibroproliferative tumors characterized by locally invasive growth of fibroblasts and excessive collagen deposition. The objective of this study is to investigate the molecular basis of the keloid scar by studying the mutation of related genes. We performed gene screening of mechanoreceptors by quantitative polymerase chain reaction (qPCR), Sanger sequencing to detect the CXCR1gene mutation, and immuno-histochemistry to determine CXCR1 protein expression. Read More

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http://dx.doi.org/10.1007/s00403-018-1847-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096561PMC
June 2018
5 Reads

Dermoscopy of chondrodermatitis nodularis helicis.

Arch Dermatol Res 2018 Jun 20. Epub 2018 Jun 20.

Department of Dermatology, Central University Hospital of Asturias, Avda. Roma s/n, 33011, Oviedo, Spain.

Chondrodermatitis nodularis helicis (CNH) is a benign auricular disease whose differentiation with nonpigmented tumors is mandatory. Clinical characteristics of CNH are well known, but there is no information about the dermoscopic features that could help differentiate CNH from squamous cell carcinoma and other non-melanoma skin cancers. To describe the dermoscopic appearance of CNH and to formulate a differential diagnostic model, we conducted  a retrospective, single center, observational dermoscopic study on a sample of 189 biopsy-proven lesions: 25 CNH; 26 squamous cell carcinomas; 62 basal cell carcinomas and 76 other benign and malignant tumors. Read More

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http://dx.doi.org/10.1007/s00403-018-1844-6DOI Listing
June 2018
9 Reads

Expression and localization of VEGFR-2 in hair follicles during induced hair growth in mice.

Arch Dermatol Res 2018 Jun 16. Epub 2018 Jun 16.

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.

Recently, VEGFR-2 has been detected not only in vascular and lymphatic endothelial cells but also in some non-vascular endothelial cells, particularly human hair follicles, sebaceous glands, and sweat glands. In addition, VEGFR-2 has been confirmed to play direct roles in hair follicle keratinocyte regulation beyond simply angiogenesis. To elucidate whether VEGFR-2 activation plays a role in hair follicle cycling regulation, immunofluorescence of VEGFR-2 expression was performed during hair cycling of the dorsum of the mouse induced by hair plucking. Read More

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http://dx.doi.org/10.1007/s00403-018-1843-7DOI Listing
June 2018
6 Reads

Reply to the letter: "Can such an animal model truly represent Henoch-Schönlein purpura?"

Arch Dermatol Res 2018 08 1;310(6):535-536. Epub 2018 Jun 1.

Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s00403-018-1839-3DOI Listing
August 2018
5 Reads

Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice.

Arch Dermatol Res 2018 Aug 17;310(6):529-532. Epub 2018 May 17.

Department of Dermatology, Vienna General Hospital, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice. Read More

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http://link.springer.com/10.1007/s00403-018-1840-x
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http://dx.doi.org/10.1007/s00403-018-1840-xDOI Listing
August 2018
9 Reads