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    4025 results match your criteria Archives of Dermatological Research[Journal]

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    Is the DLQI appropriate for medical decision-making in psoriasis patients?
    Arch Dermatol Res 2017 Nov 11. Epub 2017 Nov 11.
    Department of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.
    Dermatology Life Quality Index (DLQI) is the most commonly applied measure of health-related quality of life (HRQoL) in psoriasis patients. It is among defining criteria of moderate-to-severe psoriasis and present in treatment guidelines. Our objective was to estimate preference-based HRQoL values (i. Read More

    Expression of Janus Kinase 1 in vitiligo & psoriasis before and after narrow band UVB: a case-control study.
    Arch Dermatol Res 2017 Nov 10. Epub 2017 Nov 10.
    , Cairo, Egypt.
    Janus kinases (JAKs) are non-receptor protein tyrosine kinases that are expressed in many tissues. Once the JAKs are activated, a cascade of further signaling events is triggered involving phosphorylation of selected receptor chain tyrosines, binding of signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for some skin diseases such as psoriasis and atopic dermatitis. Read More

    Quality assessment of atopic dermatitis clinical practice guidelines in ≤ 18 years.
    Arch Dermatol Res 2017 Nov 10. Epub 2017 Nov 10.
    Group of Investigative Dermatology (GRID), Universidad de Antioquia, Carrera 25 A # 1 A Sur 45, Of 2026, Torre Médica El Tesoro, Medellín, Colombia.
    Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatment options for this condition including topical and systemic regimes. Read More

    Immunohistochemical distribution of Ki67 in epidermis of thick glabrous skin of human digits.
    Arch Dermatol Res 2017 Nov 8. Epub 2017 Nov 8.
    Department of Forensic Medicine, Faculty of Medicine, University of Nis, Nis, Republic of Serbia.
    The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67. Read More

    Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.
    Arch Dermatol Res 2017 Nov 6. Epub 2017 Nov 6.
    Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. Read More

    IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review.
    Arch Dermatol Res 2017 Oct 25. Epub 2017 Oct 25.
    School of Life Sciences, University of Nottingham, Life Sciences Building, University Park, Nottingham, NG7 2RD, UK.
    Bullous pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP. Read More

    A possible implication of reduced levels of LIF, LIFR, and gp130 in vasculopathy related to systemic sclerosis.
    Arch Dermatol Res 2017 Dec 16;309(10):833-842. Epub 2017 Oct 16.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Leukemia inhibitory factor (LIF) is a member of IL-6 family, which serves as a potent chemoattractant for neutrophils as well as a potent angiostatic factor. LIF has been implicated in various autoimmune inflammatory diseases, but its role still remains elusive in systemic sclerosis (SSc). Therefore, we investigated the potential role of LIF in the development of SSc by evaluating the clinical correlation of serum LIF levels, the expression of LIF and its receptors in skin samples, and in vitro experiments with human dermal microvascular endothelial cells. Read More

    Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis.
    Arch Dermatol Res 2017 Dec 13;309(10):815-821. Epub 2017 Oct 13.
    Institute of Pathological Physiology, Charles University, Faculty of Medicine in Hradec Kralove, Simkova 870, 50038, Hradec Kralove, Czech Republic.
    Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. Read More

    Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice.
    Arch Dermatol Res 2017 Dec 12;309(10):805-813. Epub 2017 Oct 12.
    The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266001, China.
    Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized with high heterogeneity. Recent studies have suggested that it is driven by both terminal keratinocyte differentiation defects and type 2 immune responses. The mainstay steroid topical therapy has severe side effect and new treatment is in demand. Read More

    Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients.
    Arch Dermatol Res 2017 Dec 25;309(10):851-856. Epub 2017 Sep 25.
    Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.
    Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. Read More

    Adipose-derived stem cells express higher levels of type VII collagen under specific culture conditions.
    Arch Dermatol Res 2017 Dec 22;309(10):843-849. Epub 2017 Sep 22.
    Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
    Type VII collagen (Col7) is a major component of the anchoring fibrils at the dermoepidermal junction. Adipose-derived stem cells (ADSCs) are a cell population highly useful in regenerative medicine because of their ease of isolation and their potential for multilineage differentiation. Based on the observations that K14 was expressed in undifferentiated ADSCs and the expression was downregulated after differentiation into adipocytes, we speculated that ADSCs are keratinocyte stem/progenitor cells. Read More

    Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation.
    Arch Dermatol Res 2017 Dec 21;309(10):795-803. Epub 2017 Sep 21.
    Department of Chemical and Biochemical Engineering, Dongguk University, 3-26, Pil-dong, Chung-gu, Seoul, 100-715, Republic of Korea.
    Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably increased phytoceramide content in keratinocytes. Read More

    Quantity and quality of sweating in atopic dermatitis.
    Arch Dermatol Res 2017 Dec 21;309(10):787-793. Epub 2017 Sep 21.
    Department of Dermatology, Municipal Hospital Hietzing, Wolkersbergenstraße 1, 1130, Vienna, Austria.
    Sweat may be an important factor in triggering an exacerbation of atopic dermatitis. It was the aim of this study to evaluate a possible correlation between atopic patients and hyperhidrosis-measured by a questionnaire-and to find out whether there are qualitative differences in sweat response-measured by sudomotor activity (sympathetic skin response test, SSR). Included were 100 study participants, of whom 50 were patients with atopic dermatitis and 50 were serving as control group. Read More

    Dermal-epidermal separation methods: research implications.
    Arch Dermatol Res 2017 Sep 21. Epub 2017 Sep 21.
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, 94143-0989, USA.
    Dermal-epidermal separation is an important basic investigation technique for pharmacology, toxicology and biology. To choose the optimal method for a given research need, we reviewed studies on epidermal separation. PubMed, Embase, and Web of Science were utilized. Read More

    Resveratrol suppresses melanoma by inhibiting NF-κB/miR-221 and inducing TFG expression.
    Arch Dermatol Res 2017 Dec 21;309(10):823-831. Epub 2017 Sep 21.
    Department of Traditional Chinese Medicine, Daqing Oilfield General Hospital, Daqing, China.
    Resveratrol (Res) is a natural compound with anti-cancer effects. The goal of this study is to evaluate the suppression of Res in melanoma and investigate its relationship with miRNAs during this process. The in vitro and in vivo anti-cancer abilities of Res were evaluated using cellular assays and animal model. Read More

    Updated strategies for the management, pathogenesis and molecular genetics of different forms of ichthyosis syndromes with prominent hair abnormalities.
    Arch Dermatol Res 2017 Dec 14;309(10):773-785. Epub 2017 Sep 14.
    Department of Bioinformatics and Biotechnology, Maryum Block, International Islamic University Islamabad, H-10, Islamabad, 44000, Pakistan.
    Syndromic ichthyosis is rare inherited disorders of cornification with varied disease complications. This disorder appears in seventeen subtypes associated with severe systematic manifestations along with medical, cosmetic and social problems. Syndromic ichthyosis with prominent hair abnormalities covers five major subtypes: Netherton syndrome, trichothiodystrophy, ichthyosis hypotrichosis syndrome, ichthyosis hypotrichosis sclerosing cholangitis and ichthyosis follicularis atrichia photophobia syndrome. Read More

    Digestive system in psoriasis: an update.
    Arch Dermatol Res 2017 Nov 13;309(9):679-693. Epub 2017 Sep 13.
    Dermatologikum Hamburg, Hamburg, Germany.
    Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Read More

    Comparison of suction blistering and tape stripping for analysis of epidermal genes, proteins and lipids.
    Arch Dermatol Res 2017 Nov 13;309(9):757-765. Epub 2017 Sep 13.
    Department of Research and Development, Contipro a.s., Dolní Dobrouč, Czech Republic.
    Analysis of epidermal genes, proteins and lipids is important in the research and diagnosis of skin diseases. Although punch biopsy is the first-choice technique for the skin sampling, it is unnecessarily invasive for obtaining a sample just for the epidermal analysis. Here we compare two less invasive methods, suction blistering (SB) and tape stripping (TS), for the analysis of selected epidermal genes (quantitative real-time reverse transcription PCR, qRT-PCR), proteins (western blotting, WB), and lipids in ten healthy volunteers. Read More

    Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis.
    Arch Dermatol Res 2017 Nov 11;309(9):749-756. Epub 2017 Sep 11.
    Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Read More

    Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation.
    Arch Dermatol Res 2017 Nov 9;309(9):739-748. Epub 2017 Sep 9.
    An-eX Analytical Services, 14/16 CBTC2, Capital Business Park, Cardiff, CF3 2PX, UK.
    The study objectives were to demonstrate that glycerol, when topically applied from a roll-on antiperspirant formulation, can be delivered directly to human skin ex vivo and the axillary stratum corneum (SC) in vivo, and to assess whether it improves the quality of the axillary skin barrier. Ex vivo human skin absorption of glycerol was measured following application of a roll-on antiperspirant formulation containing 4% (13)C3-glycerol. Skin distribution of (13)C3-glycerol over 24 h was assessed using gas chromatography-mass spectrometry. Read More

    Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction.
    Arch Dermatol Res 2017 Nov 7;309(9):729-738. Epub 2017 Sep 7.
    Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Ratchathewi, Bangkok, 10400, Thailand.
    Tofacitinib is a Janus kinase 3 (JAK3) inhibitor that promotes hair growth; however, the efficacy and mechanism of this effect are not yet understood. This study aimed to evaluate the efficacy and mechanism of topical tofacitinib on hair growth in mice. Eight-week-old male C57BL/6 mice were divided equally into four groups and treated topically with tofacitinib, minoxidil, or vehicle once daily for 21 days. Read More

    Incidence of bullous pemphigoid in Sweden 2005-2012: a nationwide population-based cohort study of 3761 patients.
    Arch Dermatol Res 2017 Nov 5;309(9):721-727. Epub 2017 Sep 5.
    Department of Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden.
    Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005-2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). Read More

    IL-36 cytokines are increased in acne and hidradenitis suppurativa.
    Arch Dermatol Res 2017 Oct 29;309(8):673-678. Epub 2017 Aug 29.
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in many inflammatory skin diseases. However, to date, no data have been reported on their possible involvement in acne and hidradenitis suppurativa (HS). Read More

    The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin.
    Arch Dermatol Res 2017 Nov 29;309(9):767-771. Epub 2017 Aug 29.
    Department of Dermatology, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105, Kiel, Germany.
    Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. SPINK7 is a member of the SPINK protease inhibitor family and has been described so far as a cancer-related gene in the esophagus. Read More

    Mortality in bullous pemphigoid and prognostic factors in 1st and 3rd year of follow-up in specialized centre in Poland.
    Arch Dermatol Res 2017 Nov 29;309(9):709-719. Epub 2017 Aug 29.
    Department of Dermatology and Immunodermatology, Medical University of Warsaw, Koszykowa 82a Str, 02-008, Warsaw, Poland.
    Bullous pemphigoid (BP) is associated with higher mortality and coexisting comorbidities, some of them affecting poor prognosis. The aim of the study was to identify prognostic factors causing greater mortality both in the 1st and 3rd year of follow-up and to determine the 1-, 2-, 3-year mortality rates, standardized mortality ratio (SMR) in Polish BP patients. All patients with BP (a cohort of 205 patients, mean age 76. Read More

    PAL-12, a new anti-aging hexa-peptoid, inhibits UVB-induced photoaging in human dermal fibroblasts and 3D reconstructed human full skin model, Keraskin-FT™.
    Arch Dermatol Res 2017 Nov 29;309(9):697-707. Epub 2017 Aug 29.
    College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
    Peptoids are a class of peptidomimetics whose pharmacological activities are widely investigated owing to their remarkable biological stability. However, the utilities of peptoids as cosmetic functional ingredients have not been fully explored. Here, we investigated anti-aging effects of PAL-12, a new hexa-peptoid, on UVB-induced photoaging in human dermal fibroblasts (HDFs) and a 3D reconstituted human full skin model, Keraskin-FT™. Read More

    High-frequency ultrasonography in objective evaluation of the efficacy of PUVA and UVA 1 phototherapy in mycosis fungoides.
    Arch Dermatol Res 2017 Oct 10;309(8):645-651. Epub 2017 Aug 10.
    Department of Dermatology, University of Medical Sciences, Poznań, Poland.
    The aim of the present study was to assess the effectiveness of UVA1 and PUVA therapy in treating patients with mycosis fungoides (MF) and to evaluate high-frequency ultrasonography (HF-USG) to monitor the clinical response of these patients. A total of 18 patients diagnosed with MF (stages I-IIA) underwent phototherapy, either UVA1 (6 cases) or PUVA (12 cases). Clinical response was evaluated according to modified Severity Weighted Assessment Tool (mSWAT) criteria and HF-USG (20 MHz). Read More

    Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women.
    Arch Dermatol Res 2017 Oct 27;309(8):665-671. Epub 2017 Jul 27.
    R&D Division, Biotechnology Research Institute, Celltrion, Inc., 13-1 Songdo-dong, Yeonsu-gu, Incheon, 22014, Republic of Korea.
    Maintaining a youthful appearance is a common desire among the aging population. Loss of elasticity and dermal density constitutes major causes of wrinkle formation during skin aging. In particular, periorbital wrinkles comprise the critical assessment point of skin aging. Read More

    The role of sleep in pemphigus: a review of mechanisms and perspectives.
    Arch Dermatol Res 2017 Oct 19;309(8):659-664. Epub 2017 Jul 19.
    Departamento de Psicobiologia, Universidade Federal de São Paulo, Napoleão de Barros, 925, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
    Pemphigus is an autoimmune bullous disease that causes the development of blisters and erosions on the skin and/or mucosa. Its inflammatory process is mediated by cytokines, which interact with sleep in a bidirectional manner. Pain, a frequent symptom due to pemphigus lesions, is well known to impair sleep quality. Read More

    Change in skin properties over the first 10 years of life: a cross-sectional study.
    Arch Dermatol Res 2017 Oct 19;309(8):653-658. Epub 2017 Jul 19.
    Johnson & Johnson AP Skin Testing Center, Shanghai, China.
    This study investigated skin characteristics in healthy Chinese children aged from 1 to 10 years and compared these findings with similar measures from the child's mothers. Children aged 1, 2, 3, 4, 5, and 10 years (n = 29-30 per age group) and the child's mothers were enrolled in a single-visit cross-sectional study. Clinical parameters evaluated on the face, ventral forearm, and calf were softness, smoothness, erythema, edema, rash, dryness, and scaling. Read More

    Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3.
    Arch Dermatol Res 2017 Oct 17;309(8):637-643. Epub 2017 Jul 17.
    Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
    Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene encoding the Transient Receptor Potential Cation Channel, subfamily V (TRPV3). Mutations in MBTPS2 have been recently reported in Olmsted syndrome, underscoring the overlap and the confusion in separating Olmsted from IFAP syndrome. Read More

    Association between serum/plasma adiponectin levels and immune-mediated diseases: a meta-analysis.
    Arch Dermatol Res 2017 Oct 12;309(8):625-635. Epub 2017 Jul 12.
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
    Adiponectin plays an important role in the development of immune-mediated diseases. Currently published data regarding the relationship between serum/plasma levels of adiponectin and immune-mediated diseases are inconsistent. We therefore conducted this meta-analysis to explore the association of serum/plasma adiponectin levels with immune-mediated diseases in humans. Read More

    Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach.
    Arch Dermatol Res 2017 Oct 10;309(8):611-623. Epub 2017 Jul 10.
    Aix Marseille Université, INSERM UMR_S 1090, Technological Advances for Genomics and Clinics, 13288, Marseille-Luminy, France.
    SAHA (vorinostat) is a histone deacetylase inhibitor approved by the USA Food and Drug Administration (FDA) for treating advanced refractory cutaneous T cell lymphomas. As SAHA alters the expression of many genes under control of the Sp1 transcription factor, we examined the effect of its association with the FDA-approved anticancer antibiotic Mithramycin A (MTR, plicamycin), a competitive inhibitor of Sp1 binding to DNA. Sézary syndrome (SS) cells, expanded ex vivo from peripheral blood mononuclear cells of 4 patients, were tested for their sensitivity to the drugs regarding cytotoxicity and differential responsive gene expression. Read More

    The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease.
    Arch Dermatol Res 2017 Jul 10. Epub 2017 Jul 10.
    Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, 50411, Tartu, Estonia.
    The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system's response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with the classification and monitoring of the severity of the disease. We compared the results from targeted and untargeted analyses of patients' serums with plaque psoriasis to controls. Read More

    Topically used herbal products for the treatment of hair loss: preclinical and clinical studies.
    Arch Dermatol Res 2017 Oct 10;309(8):595-610. Epub 2017 Jul 10.
    Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110, Jablonna, Poland.
    Currently available conventional therapies of hair loss using synthetic drugs are still imperfect and have a number of limitations. Their effectiveness as well as the safety of their use is often questioned. It has led to an increased interest in alternative treatments with fewer side-effects such as formulations containing herbs and/or their active constituents. Read More

    Autoantibodies to desmogleins 1 and 3 in patients with lichen planus.
    Arch Dermatol Res 2017 Jul 3. Epub 2017 Jul 3.
    Azad University of Medical Sciences, Tehran, Iran.
    There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls. The enzyme-linked immunosorbent assay test was performed on serum samples of 24 cases of erosive oral LP, 29 cases of reticular oral LP, 30 cases of cutaneous LP and 30 healthy controls. The severity of oral LP was evaluated by Reticulation, Erosion and Ulceration scoring system. Read More

    The relevance of serum vitamin D in psoriasis: a review.
    Arch Dermatol Res 2017 Jul 3. Epub 2017 Jul 3.
    Department of Dermatology, The Charles Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
    Observational research has identified low serum levels of 25-hydroxyvitamin D (25[OH]D) in many non-skeletal diseases. Whether this is causal or due to underlying illness is unknown. Low serum 25[OH]D levels are also reported in the general population. Read More

    Topical application of Dermatophagoides farinae or oxazolone induces symptoms of atopic dermatitis in the rabbit ear.
    Arch Dermatol Res 2017 Jun 30. Epub 2017 Jun 30.
    Laboratory for Tissue Repair and Regenerative Surgery, Plastic Surgery Division, Department of Surgery, Northwestern University, Feinberg School of Medicine, 745 Fairbanks Ct, Chicago, IL, 60611, USA.
    Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of the epidermis, and dermal infiltration of inflammatory cells. Appropriate animal models that recapitulate human AD and allow the analysis of disease processes in a reliable manner are essential to the study of AD. In this study, we established two AD models in rabbits by applying an allergen, Dermatophagoides farinae (Der f), or a hapten, oxazolone (OXZ). Read More

    Keratin gene mutations influence the keratinocyte response to DNA damage and cytokine induced apoptosis.
    Arch Dermatol Res 2017 Jun 24. Epub 2017 Jun 24.
    Faculty of Medicine, Medical Centre for Molecular Biology, University of Ljubljana, Ljubljana, Slovenia.
    The keratin filament cytoskeleton is vital to the normal function of epithelial cells. It provides structural support and regulates different aspects of cell metabolism. Mutations in keratins 5 and 14 cause a skin fragility disorder, epidermolysis bullosa simplex (EBS). Read More

    The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.
    Arch Dermatol Res 2017 Jun 20. Epub 2017 Jun 20.
    Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of the miRNA pathway and regulates miRNA formation and function. Read More

    Rituximab treatment in pemphigus vulgaris: effect on circulating Tregs.
    Arch Dermatol Res 2017 Jun 19. Epub 2017 Jun 19.
    Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al-Manial, Cairo, 11956, Egypt.
    Rituximab (RTX) has been used successfully to treat refractory pemphigus. We aimed to assess the response of pemphigus vulgaris (PV) cases to RTX therapy and its effect on CD4(+)CD25(+) (T regulatory) cells level. Sixteen PV patients were included in this study, each received one cycle of two RTX infusions (1000 mg on days 1 and 15). Read More

    The role of microbiota, and probiotics and prebiotics in skin health.
    Arch Dermatol Res 2017 Aug 19;309(6):411-421. Epub 2017 Jun 19.
    BioRegenerative Sciences, Inc., 505 Coast Blvd South #208, La Jolla, CA, 92037, USA.
    During the past decade, scientists have made great strides in understanding the microbiome's role in human health. Today, the microbiome has become key in scientific research, therapeutic development, medical treatment, and as a news feature in the media. Most studies have focused on the microbiome of our gut, but recently researchers have turned their attention to other microbiomes, including that of the skin. Read More

    Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them.
    Arch Dermatol Res 2017 Jun 19. Epub 2017 Jun 19.
    Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul, 06273, Korea.
    Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. Read More

    BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines.
    Arch Dermatol Res 2017 Aug 7;309(6):491-497. Epub 2017 Jun 7.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Bromodomain and external domain (BET) proteins regulate cell growth, proliferation, cell cycle, and differentiation in various cancers. Therefore, they have emerged as interesting targets. The effect of BET inhibitor on cutaneous T-cell lymphoma (CTCL), however, is yet to be known. Read More

    Serum fatty acid profile in psoriasis and its comorbidity.
    Arch Dermatol Res 2017 Jul 5;309(5):371-380. Epub 2017 Jun 5.
    Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia str. 14, 15-540, Białystok, Poland.
    Psoriasis is a chronic inflammatory skin disease that is accompanied by metabolic disturbances and cardio-metabolic disorders. Fatty acids (FAs) might be a link between psoriasis and its comorbidity. The aim of the study was to evaluate serum concentrations of FAs and to investigate their association with the disease activity, markers of inflammation and possible involvement in psoriatic comorbidity: obesity, type 2 diabetes and hypertension. Read More

    In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesions.
    Arch Dermatol Res 2017 May 31. Epub 2017 May 31.
    Department of Skin Biology and Pharmacology, The Johnson & Johnson Skin Research Center, Johnson & Johnson Consumer Inc., 199 Grandview Road, Skillman, NJ, 08558, USA.
    Acne vulgaris is a disease of pilosebaceous units with multifactorial pathogenesis, including hyperkeratinization, increased sebum secretion, and inflammation. Recently, it was suggested that acne subjects may have also impaired skin barrier. We hypothesized that excess unsaturated free fatty acids (UFFA) present in the sebum may cause barrier impairment associated with increased follicular stratum corneum (SC) thickening and inflammation seen in acne. Read More

    Oxidation products are increased in patients affected by non-segmental generalized vitiligo.
    Arch Dermatol Res 2017 Aug 27;309(6):485-490. Epub 2017 May 27.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Several lines of evidence support the relevance of reactive oxygen species (ROS) in vitiligo, but the exact role of glycation and oxidation of macromolecules needs to be better addressed. To investigate the involvement of advanced oxidation protein products (AOPPs) and advanced glycation end-products (AGEs), we performed a case-control association study by spectrofluorimetry and spectrophotometry, in 47 patients with non-segmental generalized vitiligo and 47 age- and sex-matched controls. Significantly higher levels of both AOPPs (p < 0. Read More

    Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis.
    Arch Dermatol Res 2017 Aug 20;309(6):461-477. Epub 2017 May 20.
    Institute of Aging Research and the Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
    Previous studies have explored the relationship of PTPN22 and TLR9 polymorphisms with systemic lupus erythematosus (SLE). In consideration of the population stratification, conflicting results and updating data, we conducted a comprehensive meta-analysis, which consists of a total of 17 research articles (9120 cases and 11,724 controls) for PTPN22 and 20 articles (including up to 2808 cases and 3386 controls) for TLR9. Significant association was verified between PTPN22 rs2476601 and SLE in the overall population (OR = 1. Read More

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