4,078 results match your criteria Archives of Dermatological Research[Journal]


Linoleate-enriched diet increases both linoleic acid esterified to omega hydroxy very long chain fatty acids and free ceramides of canine stratum corneum without effect on protein-bound ceramides and skin barrier function.

Arch Dermatol Res 2018 Jul 11. Epub 2018 Jul 11.

LBTM1 "Fundamental, clinical and therapeutic aspects of the skin barrier function", University of Lyon-1, Lyon, France.

Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was studied by feeding two groups of five dogs differential amounts of linoleic acid (LA) for three months. SC was harvested by tape stripping and lipids were analyzed by thin-layer chromatography and mass spectrometry. Read More

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Phenotype variability in tumor disorders of the skin appendages associated with mutations in the CYLD gene.

Arch Dermatol Res 2018 Jul 4. Epub 2018 Jul 4.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Mutations in the tumor suppressor gene CYLD underlie phenotypically heterogeneous hereditary tumor disorders of the skin appendages. These diseases are inherited autosomal dominantly and include Brooke-Spiegler syndrome (BSS; OMIM 605041), familial cylindromatosis (FC; OMIM 132700) and multiple familial trichoepithelioma (MFT; OMIM 601606). Clinically, cylindromas, trichoepitheliomas and spiradenomas can be found in affected individuals. Read More

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Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.

Arch Dermatol Res 2018 Aug 9;310(6):515-522. Epub 2018 Jun 9.

Department of Dermatology and Venereology, Medical University of Lodz, Plac Hallera 1, 90-647, Lodz, Poland.

Bullous pemphigoid (BP) constitutes the most prevalent disease in the group of bullous dermatoses with the autoimmune background. Some authors suggest that certain cytokines (IL-2, IFN-γ) may be transported by P-glycoprotein (P-gp), the product of the ABCB1 gene. ABCB1 polymorphism might affect not only the effectiveness of treatment with drugs that are P-gp substrates but also contribute to the development of diseases, including BP. Read More

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How to weight patient-relevant treatment goals for assessing treatment benefit in psoriasis: preference elicitation methods vs. rating scales.

Arch Dermatol Res 2018 Jun 23. Epub 2018 Jun 23.

German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

In psoriasis, several patient-relevant treatment goals must be met to be able to consider a treatment beneficial. To assess treatment benefit, the validated questionnaire Patient Benefit Index (PBI) can be used. Its global score summarizes the degree of patient-relevant treatment goals achieved after treatment, weighted by their individual importance on rating scales. Read More

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Identification of a novel mutation in the mechanoreceptor-encoding gene CXCR1 in patients with keloid.

Arch Dermatol Res 2018 Jun 21. Epub 2018 Jun 21.

The Department of Dermatology, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

Keloids are skin fibroproliferative tumors characterized by locally invasive growth of fibroblasts and excessive collagen deposition. The objective of this study is to investigate the molecular basis of the keloid scar by studying the mutation of related genes. We performed gene screening of mechanoreceptors by quantitative polymerase chain reaction (qPCR), Sanger sequencing to detect the CXCR1gene mutation, and immuno-histochemistry to determine CXCR1 protein expression. Read More

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Dermoscopy of chondrodermatitis nodularis helicis.

Arch Dermatol Res 2018 Jun 20. Epub 2018 Jun 20.

Department of Dermatology, Central University Hospital of Asturias, Avda. Roma s/n, 33011, Oviedo, Spain.

Chondrodermatitis nodularis helicis (CNH) is a benign auricular disease whose differentiation with nonpigmented tumors is mandatory. Clinical characteristics of CNH are well known, but there is no information about the dermoscopic features that could help differentiate CNH from squamous cell carcinoma and other non-melanoma skin cancers. To describe the dermoscopic appearance of CNH and to formulate a differential diagnostic model, we conducted  a retrospective, single center, observational dermoscopic study on a sample of 189 biopsy-proven lesions: 25 CNH; 26 squamous cell carcinomas; 62 basal cell carcinomas and 76 other benign and malignant tumors. Read More

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June 2018
3 Reads

Expression and localization of VEGFR-2 in hair follicles during induced hair growth in mice.

Arch Dermatol Res 2018 Jun 16. Epub 2018 Jun 16.

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.

Recently, VEGFR-2 has been detected not only in vascular and lymphatic endothelial cells but also in some non-vascular endothelial cells, particularly human hair follicles, sebaceous glands, and sweat glands. In addition, VEGFR-2 has been confirmed to play direct roles in hair follicle keratinocyte regulation beyond simply angiogenesis. To elucidate whether VEGFR-2 activation plays a role in hair follicle cycling regulation, immunofluorescence of VEGFR-2 expression was performed during hair cycling of the dorsum of the mouse induced by hair plucking. Read More

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Reply to the letter: "Can such an animal model truly represent Henoch-Schönlein purpura?"

Arch Dermatol Res 2018 Aug 1;310(6):535-536. Epub 2018 Jun 1.

Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, People's Republic of China.

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Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice.

Arch Dermatol Res 2018 Aug 17;310(6):529-532. Epub 2018 May 17.

Department of Dermatology, Vienna General Hospital, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice. Read More

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Can such an animal model truly represent Henoch-Schönlein purpura?

Arch Dermatol Res 2018 May 14. Epub 2018 May 14.

Department of Nephrology and Rheumatology, Children's Hospital of Soochow University, Jingde Street 303, Suzhou, 215000, Jiangsu, China.

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May 2018
1 Read

Stratum corneum substantivity: drug development implications.

Arch Dermatol Res 2018 May 11. Epub 2018 May 11.

Department of Dermatology, School of Medicine, University of California, San Francisco, 90 Medical Center Way, Box 0989, Surge Building, Room 110, San Francisco, CA, 94143, USA.

There are at least 15 factors that influence the ability of chemicals to penetrate the skin. Substantivity is yet another factor and allows penetrants to remain on and in skin for many days. As many skin pathologies involve stratum corneum and require multiple dosing of topicals, understanding substantivity mechanisms may provide insight for topical dosing strategies. Read More

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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review.

Arch Dermatol Res 2018 Aug 8;310(6):505-513. Epub 2018 May 8.

VA Salt Lake City Health Care System, 500 Foothill Drive, Salt Lake City, UT, 84148, USA.

Available descriptive statistics for patients with metastatic basal cell carcinoma (mBCC) are limited. To describe disease characteristics, treatment patterns, survival outcomes, and prognostic factors of patients with mBCC, we conducted a retrospective review of electronic health records in the Department of Veterans Affairs (VA). The primary outcome was survival. Read More

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Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus.

Arch Dermatol Res 2018 Aug 4;310(6):523-528. Epub 2018 May 4.

Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of São Paulo, LIM-56, Av. Dr. Enéas de Carvalho Aguiar, 470, 3rd floor, São Paulo, 05403-000, Brazil.

Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns) may also contribute to the inflammatory response in LP. HMGB1 (high mobility group box 1 protein) is one of the major DAMPs that induces inflammation and could trigger LP disease. Read More

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August 2018
1 Read

Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile.

Arch Dermatol Res 2018 Aug 4;310(6):495-504. Epub 2018 May 4.

Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Utsunomiya, Tochigi, 321-8505, Japan.

We determined whether compensating ceramides in the stratum corneum (SC) may ameliorate the impaired barrier function and subsequently attenuate the enhanced skin sensitivity. Treatment for 4 weeks with the ceramide complex cream or the placebo cream significantly ameliorated the intensity of lactic acid sensations in 39 female subjects with sensitive skin, the degree of which was attenuated to a greater extent at 1 week by the ceramide complex cream compared with the placebo cream. The amelioration of skin sensations was accompanied by a significant increase in total ceramide content in the SC elicited by the ceramide complex cream that was significantly more effective than the placebo cream at 4 weeks. Read More

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CXCL13 is an activity marker for systemic, but not cutaneous lupus erythematosus: a longitudinal cohort study.

Arch Dermatol Res 2018 Aug 4;310(6):485-493. Epub 2018 May 4.

Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036, Graz, Austria.

Serum levels of the IFN-regulated cytokine CXCL13 have been found to correlate with SLEDAI and renal involvement in systemic lupus erythematosus. This study investigates whether CXCL13 can also be a marker of disease activity in patients with subacute cutaneous or chronic cutaneous lupus erythematosus (SCLE, CCLE). We analysed CXCL13 levels in 60 patients' sera (18 SLE, 19 SCLE, 23 CCLE) at five time points within 1 year and correlated these levels with disease activity scores and laboratory markers. Read More

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Ex vivo nonlinear microscopy imaging of Ehlers-Danlos syndrome-affected skin.

Arch Dermatol Res 2018 Jul 3;310(5):463-473. Epub 2018 May 3.

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 41 Mária Street, Budapest, 1085, Hungary.

Ehlers-Danlos syndrome (EDS) is the name for a heterogenous group of rare genetic connective tissue disorders with an overall incidence of 1 in 5000. The histological characteristics of EDS have been previously described in detail in the late 1970s and early 1980s. Since that time, the classification of EDS has undergone significant changes, yet the description of the histological features of collagen morphology in different EDS subtypes has endured the test of time. Read More

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July 2018
1 Read

Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal.

Arch Dermatol Res 2018 Jul 27;310(5):453-462. Epub 2018 Apr 27.

Centre for Dermatology Research, The University of Manchester, Manchester, UK.

In murine skin, dermal white adipose tissue (DWAT) undergoes major changes in thickness in synchrony with the hair cycle (HC); however, the underlying mechanisms remain unclear. We sought to elucidate whether increased DWAT thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain the decreased DWAT thickness during catagen. In addition, we compared HC-associated DWAT changes between spontaneous and depilation-induced hair follicle (HF) cycling to distinguish between spontaneous and HF trauma-induced events. Read More

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July 2018
2 Reads

Determinants of quality of life and psychological status in adults with psoriasis.

Arch Dermatol Res 2018 Jul 23;310(5):443-451. Epub 2018 Apr 23.

School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, UCSI University, Kuala Lumpur, Malaysia.

We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Read More

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Expression of IL33 and IL35 in oral lichen planus.

Arch Dermatol Res 2018 Jul 9;310(5):431-441. Epub 2018 Apr 9.

Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, 310 Great King Street, Dunedin, 9054, New Zealand.

Oral lichen planus (OLP) is a complex immunological disorder, mediated in part by the release of cytokines by activated T-cells. Recently, the role of novel cytokines including IL33 and IL35 has been described in various chronic inflammatory diseases. IL33, a member of the IL-1 superfamily of cytokines, functions as an 'alarmin' released after cell necrosis to alert the immune system to tissue damage or stress. Read More

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July 2018
1 Read

Increased tenascin C and DKK1 in vitiligo: possible role of fibroblasts in acral and non-acral disease.

Arch Dermatol Res 2018 Jul 31;310(5):425-430. Epub 2018 Mar 31.

Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Recently, multiple culprits-in addition to melanocytes-have been implicated in the pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has not been clearly elucidated. Read More

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July 2018
5 Reads

Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: a review of clinical data.

Arch Dermatol Res 2018 Aug 24;310(6):475-483. Epub 2018 Mar 24.

Psoriasis-Center at the Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.

Fumarates (fumaric acid esters, FAEs) are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. In 1994, a proprietary combination of FAEs was licensed for psoriasis by the German Drug Administration for use within Germany. Since then, fumarates have been established as one of the most commonly used treatments for moderate-to-severe psoriasis in Germany and other countries. Read More

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August 2018
3 Reads

UVA-photoprotective potential of silymarin and silybin.

Arch Dermatol Res 2018 Jul 21;310(5):413-424. Epub 2018 Mar 21.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.

Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. Read More

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July 2018
1 Read

Anthocyanins from black soybean seed coat prevent radiation-induced skin fibrosis by downregulating TGF-β and Smad3 expression.

Arch Dermatol Res 2018 Jul 19;310(5):401-412. Epub 2018 Mar 19.

Department of Radiation Oncology, Keimyung University School of Medicine, Daegu, Republic of Korea.

The aim of this study was to evaluate the protective effects of anthocyanins from the black soybean seed coat against radiation injury in dermal fibroblasts and mouse skin. Dermal fibroblasts treated with 50 and 100 µg/mL anthocyanins were irradiated with single doses of 20 Gy. Cell viability, intracellular reactive oxygen species (ROS) production, and mRNA expression were measured. Read More

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July 2018
3 Reads

Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia.

Arch Dermatol Res 2018 Jul 16;310(5):391-399. Epub 2018 Mar 16.

Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.

Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. Read More

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July 2018
2 Reads

Autologous platelet-rich plasma and triamcinolone acetonide intralesional injection in the treatment of oral erosions of pemphigus vulgaris: a pilot study.

Arch Dermatol Res 2018 May 10;310(4):375-381. Epub 2018 Mar 10.

Department of Dermatology, Cairo University School of Medicine, Kasr Al Ainy hospital, Al-Manial, Cairo, PO 11956, Egypt.

Oral erosions of pemphigus vulgaris (PV) represent a therapeutic challenge. In this work we compared intralesional injection of steroids (ILS) and autologous platelet-rich plasma (PRP) treatment of oral erosions of PV. In this split-mouth randomized double blind study, one side of the buccal mucosa of 11 PV patients was injected with 10 mg/ml triamcinolone and the opposite side was injected with 1 millilitre of autologous PRP every 14 days for 3 months. Read More

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May 2018
5 Reads

IL-17 inhibition: is it the long-awaited savior for alopecia areata?

Arch Dermatol Res 2018 Jul 1;310(5):383-390. Epub 2018 Mar 1.

International Hair Research Foundation (IHRF), Milan, Italy.

Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available information on the connection between AA and IL-17 is described. Read More

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July 2018
2 Reads

Effects of topical topiramate in wound healing in mice.

Arch Dermatol Res 2018 May 23;310(4):363-373. Epub 2018 Feb 23.

Nursing School, University of Campinas, Campinas, SP, 13084-970, Brazil.

Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6. Read More

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May 2018
1 Read

Leptin regulates the pro-inflammatory response in human epidermal keratinocytes.

Arch Dermatol Res 2018 May 21;310(4):351-362. Epub 2018 Feb 21.

College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

The role of leptin in cutaneous wound healing process has been suggested in genetically obese mouse studies. However, the molecular and cellular effects of leptin on human epidermal keratinocytes are still unclear. In this study, the whole-genome-scale microarray analysis was performed to elucidate the effect of leptin on epidermal keratinocyte functions. Read More

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May 2018
4 Reads

Effect of Dickkopf1 on the senescence of melanocytes: in vitro study.

Arch Dermatol Res 2018 May 13;310(4):343-350. Epub 2018 Feb 13.

Department of Zoology, Panjab University, Chandigarh, 160014, India.

Fibroblasts secrete several growth factors which are important for the regulation of skin pigmentation. Dickkopf1 (DKK1) is also secreted by fibroblasts which inhibit the growth and function of melanocytes. Therefore, the study was designed to check the role of DKK1 in vitiligo pathogenesis. Read More

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May 2018
2 Reads

Treatment preferences and treatment satisfaction among psoriasis patients: a systematic review.

Arch Dermatol Res 2018 May 13;310(4):271-319. Epub 2018 Feb 13.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

A critical gap exists in determining treatment preferences and treatment satisfaction from patient perspectives, which is paramount to achieving therapeutic success. The objective of this systematic review is to determine factors influencing treatment preferences and treatment satisfaction among psoriasis patients. PubMed, EMBASE, and Web of Science databases were searched between November 1, 2010, and December 1, 2017. Read More

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May 2018
2 Reads

BPDAI and ABSIS correlate with serum anti-BP180 NC16A IgG but not with anti-BP230 IgG in patients with bullous pemphigoid.

Arch Dermatol Res 2018 Apr 8;310(3):255-259. Epub 2018 Feb 8.

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.

Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by autoantibody production against BP180 and BP230. Two scoring systems have been validated for BP including: Bullous Pemphigoid Disease Area Index (BPDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). In this study, we investigated correlations between both scoring systems and either anti-BP180 NC16A or anti-BP230 values. Read More

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April 2018
1 Read

Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.

Arch Dermatol Res 2018 May 7;310(4):329-342. Epub 2018 Feb 7.

Department of Dermatology, Venereology and Allergology, HELIOS-Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Germany.

The histopathologic differentiation between Spitz nevus and melanoma is of particular interest in routine diagnostic procedures of melanocytic tumors. Atypical Spitz nevi are sometimes difficult to distinguish from melanoma. There is still no single criterion that ensures a distinction of melanoma and atypical Spitz nevus. Read More

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May 2018
2 Reads

Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia.

Arch Dermatol Res 2018 May 3;310(4):321-327. Epub 2018 Feb 3.

Department of Dermatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

The late cornified envelope (LCE) gene cluster is located on chromosome 1q21, including LCE1-LCE6. Several single nucleotide polymorphisms (SNPs) in the LCE cluster were associated with susceptibility to psoriasis in Chinese population. However, there is no report on the relationship in ethnic minority areas in China. Read More

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May 2018
3 Reads

Subcutaneous injection of multipotent mesenchymal stromal cells admixed with melanoma cells in mice favors tumor incidence and growth: a systematic review and meta-analysis.

Arch Dermatol Res 2018 Apr 3;310(3):231-240. Epub 2018 Feb 3.

Programa de Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande (FURG), Av Itália, Km 8, Rio Grande, RS, 96210-900, Brazil.

Multipotent mesenchymal stem/stromal cells (MSCs) have strong tropism towards cancer cells, thus being tested as tools for the targeted delivery of therapeutic substances for the treatment of melanoma. However, different experimental approaches for melanoma induction and MSC treatment can have a direct impact on the outcomes. Systematic search was carried out in three databases (PubMed, Scopus, and Web of Science) to include all studies, where stem cells were used as intervention for animal models for melanoma. Read More

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April 2018
2 Reads

Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D.

Arch Dermatol Res 2018 Apr 1;310(3):221-230. Epub 2018 Feb 1.

Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Perth, WA, 6008, Australia.

Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and regulatory T (T) cells. 1,25(OH)D also promotes immunoregulation by mast cells, and inhibits the development of T helper type-9 (Th9) cells that secrete interleukin-9 (IL-9). Here, we investigated the ability of topical 1,25(OH)D to suppress contact dermatitis through an IL-9-dependent process, examining mast cells and IL-9-secreting T cells. Read More

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April 2018
3 Reads

Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients.

Arch Dermatol Res 2018 Apr 24;310(3):209-220. Epub 2018 Jan 24.

Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cells against basal epithelial cells. MicroRNAs (MiRNAs) are short non-coding RNA that plays critical role in gene expression at post-transcriptional levels. Much evidence showed that miRNAs play an important role in regulating immune response and cancer development. Read More

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April 2018
5 Reads

Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis.

Arch Dermatol Res 2018 Apr 24;310(3):197-207. Epub 2018 Jan 24.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

The Stat6VT mouse model of atopic dermatitis (AD) is induced by T-cell-specific expression of a constitutively active form of the protein signal transducer and activator of transcription 6 (STAT6). Although AD-like lesions are known to develop in Stat6VT mice, this study was designed to determine if these mice develop acute and chronic phases of disease similar to humans. To address this, AD-like lesions from Stat6VT mice were harvested at two different timepoints relative to their onset. Read More

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April 2018
8 Reads

Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis.

Arch Dermatol Res 2018 May 23;310(4):261-269. Epub 2018 Jan 23.

The Children's Hospital, Zhejiang University School of Medicine, No. 3333 Binsheng Road, Hangzhou, 310052, Zhejiang, China.

A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results. The present study assessed the response rate and adverse events of topical timolol in the treatment of infantile hemangioma. Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and Cochrane library were searched until October 2016. Read More

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May 2018
3 Reads

The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis.

Arch Dermatol Res 2018 Apr 23;310(3):187-196. Epub 2018 Jan 23.

Center for Bioscience Research and Education, Utsunomiya University, Tochigi, Japan.

We recently found that treatment of normal human melanocytes (NHMs) with the antioxidant astaxanthin (AX) suppresses the stem cell factor (SCF)-stimulated protein expression levels of microphthalmia-associated transcription factor (MITF) at 1.5 h and of tyrosinase and endothelin B receptor at 96 h post-treatment. Analysis of the signaling cascade(s) involved revealed that although the major SCF-activated signaling cascade that leads to CREB activation (the c-KIT/Shc/Raf-1/ERK/RSK/CREB axis) is not interrupted, the increased phosphorylation of CREB is significantly abrogated by AX. Read More

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April 2018
2 Reads

Skin depigmenting action of silkworm (Bombyx mori L.) droppings in zebrafish.

Arch Dermatol Res 2018 Apr 22;310(3):245-253. Epub 2018 Jan 22.

Graduate School of Biotechnology, Kyung Hee University, Global Campus, Yongin, Gyeonggi, 446-701, Republic of Korea.

The excrement of silkworms (Bombyx mori L.), referred to here as silkworm droppings (SDs), is used as a traditional drug in eastern medicine to treat skin diseases such as urticaria and atopy. However, the depigmentation effects of SDs have not previously been evaluated. Read More

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April 2018
2 Reads
2.27 Impact Factor

Construction of a plasmid vector containing epidermal growth factor receptor and C-Jun shRNA.

Arch Dermatol Res 2018 Apr 20;310(3):241-243. Epub 2018 Jan 20.

Department of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650103, Yunnan, China.

The objective of this study was to construct a plasmid vector for EGFR-hm-1 and C-Junh-825 small interfering RNA (siRNA). EGFR-hm-1 and C-Jun-hm-825 oligonucleotide fragments were synthesized and short hairpin RNA (shRNA) were amplified by PCR. Plasmids were isolated from E. Read More

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April 2018
2 Reads

Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids.

Arch Dermatol Res 2018 Mar 19;310(2):165-172. Epub 2018 Jan 19.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Serotonin (5-hydroxytryptamine or 5-HT) is a neurotransmitter in itch and impaired serotonin signaling has been linked to a variety of itch conditions. Intradermal injection of 5-HT induces scratching behavior in mice through stimulation of 5-HT receptors. Previous studies have demonstrated that selective 5-HT1B/1D receptors agonists, including sumatriptan, inhibits neurotransmission. Read More

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March 2018
3 Reads

Histological findings after argon plasma coagulation: an ex-vivo study revealing a possible role in superficial ablative treatment of the skin.

Arch Dermatol Res 2018 Mar 19;310(2):157-163. Epub 2018 Jan 19.

Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.

Argon plasma coagulation (APC) is an electrosurgical technique which can be used to ablate skin lesions with limited invasion depth into dermal tissue. Hence, APC might be well suited for the removal of epithelial tumours. However, there are no data on the effects of APC on human skin tissue. Read More

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March 2018
2 Reads

Matrix metalloproteinase-2 and -9 activity levels increase in cutaneous lupus erythematosus lesions and correlate with disease severity.

Arch Dermatol Res 2018 Mar 18;310(2):173-179. Epub 2018 Jan 18.

Department of Dermatology and Venereology, School of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey.

Lupus erythematosus is a chronic autoimmune disease characterized by remissions and exacerbations. Accumulated evidence indicated that matrix metalloproteinases (MMPs) are upregulated in inflammatory cells of cutaneous lupus erythematosus (CLE); however, the activity levels of these proteases have remained uncharacterized. To elucidate the significance of MMP-2, MMP-9, and TIMP-1 in CLE pathogenesis, gelatin zymography was used to investigate pro and active levels of MMP-2 and MMP-9 in lesional and perilesional skin biopsies obtained from twenty-two CLE patients. Read More

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March 2018
2 Reads

NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.

Arch Dermatol Res 2018 Mar 18;310(2):147-156. Epub 2018 Jan 18.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Keratin-17 (K17) is a cytoskeletal protein produced by keratinocytes (KCs), which is overexpressed in psoriasis and may play a pivotal role in its pathogenesis. Narrow-band ultraviolet B (NB-UVB) irradiation is used as a general treatment for psoriasis, although its impact on K17 expression has yet to be determined. In this study, we aimed to investigate the effect of NB-UVB irradiation on K17 expression and its signaling pathways. Read More

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March 2018
4 Reads

Inate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study.

Arch Dermatol Res 2018 Mar 12;310(2):139-146. Epub 2018 Jan 12.

Department of Dermatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, sala 3021, 05403-000, São Paulo, Brazil.

Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Read More

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March 2018
3 Reads

Increased senescent CD8+ T cells in the peripheral blood mononuclear cells of Behçet's disease patients.

Arch Dermatol Res 2018 Mar 18;310(2):127-138. Epub 2017 Dec 18.

Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.

Behçet's disease (BD) is a chronic inflammatory disease characterized by recurrent mucocutaneous, ocular, and skin lesions. Immunosenescence is associated with increased susceptibility to infection and chronic low grade inflammation. This study aimed to investigate the differences in the frequencies of immunosenescent cells in the peripheral blood mononuclear cells (PBMCs) of patients with BD. Read More

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March 2018
4 Reads

Co-culture of human fibroblasts and Borrelia burgdorferi enhances collagen and growth factor mRNA.

Arch Dermatol Res 2018 Mar 6;310(2):117-126. Epub 2017 Dec 6.

Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, 8036, Graz, Austria.

Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. Read More

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March 2018
5 Reads

DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts.

Arch Dermatol Res 2018 Mar 4;310(2):107-115. Epub 2017 Dec 4.

Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, No. 57, South people Road, Zhanjiang, 524001, Guangdong, China.

The excessive growth of fibroblasts in keloid is closely related to the status of gene methylation. The aim of this project was to study whether keloid development is related to DNA methylation in the CDC2L1 gene promoter region. DNA methylation of the promoter of this gene was analyzed by bisulfite sequencing and verified by DNA methylation-specific polymerase chain reaction. Read More

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March 2018
6 Reads

5α-Reductase isozymes and aromatase mRNA levels in plucked hair from young women with female pattern hair loss.

Arch Dermatol Res 2018 Jan 28;310(1):77-83. Epub 2017 Nov 28.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda. de la Investigación, 18016, Granada, Spain.

Female pattern hair loss (FPHL) is an important hair disorder, especially when young women are affected. However, pharmacological treatments are not successful in all women. Androgens, especially dihydrotestosterone (DHT), may play a role in FPHL, but many women with this disorder have normal serum androgen levels. Read More

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January 2018
3 Reads