4,144 results match your criteria Archives of Dermatological Research[Journal]


NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway.

Arch Dermatol Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Previous studies have identified neuron navigator 2(NAV2) as an oncogene in several human tumors. However, the NAV2 gene expression changes and its role in the pathogenesis of cutaneous melanoma have not been clearly illustrated. Further investigations of NAV2 in cutaneous melanoma may provide new mechanistic insight and treatment strategy for this disease. Read More

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http://dx.doi.org/10.1007/s00403-019-01909-wDOI Listing

Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis.

Arch Dermatol Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540, Białystok, Poland.

Fatty acid-binding proteins play an inconclusive role in lipid metabolism and cardiometabolic diseases (CMDs) which are closely related with psoriasis. Aim of the study was to investigate the diagnostic value of serum liver fatty acid-binding protein (FABP1) level and associations with disease severity, inflammation or metabolic parameters and influence of systemic treatment in psoriatic patients. The study included thirty-three patients with active plaque-type psoriasis and eleven healthy volunteers. Read More

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http://dx.doi.org/10.1007/s00403-019-01917-wDOI Listing

Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Arch Dermatol Res 2019 Apr 6. Epub 2019 Apr 6.

Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there are little data about LLT1 expression in human solid tumors. Read More

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http://dx.doi.org/10.1007/s00403-019-01916-xDOI Listing

Association of dermatomyositis with systemic and opportunistic infections in the United States.

Arch Dermatol Res 2019 Apr 6. Epub 2019 Apr 6.

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.

Patients with dermatomyositis have multiple risk factors for serious and opportunistic infections, including immune dysregulation, long-term systemic corticosteroid treatment and comorbid health conditions. We sought to determine whether dermatomyositis is associated with increased odds and burden of systemic, opportunistic and antibiotic-resistant infections. We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, containing a cross-sectional representative 20% sample of all hospitalizations in the US. Read More

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http://link.springer.com/10.1007/s00403-019-01913-0
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http://dx.doi.org/10.1007/s00403-019-01913-0DOI Listing
April 2019
5 Reads

Extracutaneous involvement of pyoderma gangrenosum.

Arch Dermatol Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology and OHSU Wound and Hyperbaric Medicine, Oregon Health and Science University, 3303 SW Bond Ave Center for Health and Healing Building 1, Suite 16, Portland, OR, 97239, USA.

Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Read More

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http://dx.doi.org/10.1007/s00403-019-01912-1DOI Listing
March 2019
1 Read

Pre-natal folic acid and iron supplementation and atopic dermatitis in the first 6 years of life.

Arch Dermatol Res 2019 Mar 28. Epub 2019 Mar 28.

Lazio Regional Health Authority, Rome, Italy.

Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. Read More

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http://dx.doi.org/10.1007/s00403-019-01911-2DOI Listing
March 2019
1 Read

Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study.

Arch Dermatol Res 2019 Mar 16. Epub 2019 Mar 16.

Department of Dermatology, University Hospital Zurich, Petersgraben 4, 4031, Zurich, Switzerland.

IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. Read More

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http://dx.doi.org/10.1007/s00403-019-01907-yDOI Listing
March 2019
3 Reads

Mast cells in hidradenitis suppurativa: a clinicopathological study.

Arch Dermatol Res 2019 May 15;311(4):331-335. Epub 2019 Mar 15.

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Mast cells (MC) have been observed in hidradenitis suppurativa (HS) lesions. Their potential role in the pathogenesis of HS is unknown. The aim of this study was to assess the number and distribution MC in HS lesions, and its association with disease and itch severity. Read More

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http://dx.doi.org/10.1007/s00403-019-01910-3DOI Listing
May 2019
2 Reads

Quality of life and contact with healthcare systems among patients with psoriasis and psoriatic arthritis: results from the NORdic PAtient survey of Psoriasis and Psoriatic arthritis (NORPAPP).

Arch Dermatol Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Psoriasis (skin psoriasis, PsO) is a chronic inflammatory condition. In about one-third of cases, the joints are affected (psoriatic arthritis, PsA). Both conditions, especially PsA, profoundly impact patients' health-related quality of life (HRQoL). Read More

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http://dx.doi.org/10.1007/s00403-019-01906-zDOI Listing
March 2019
3 Reads

From pathogenesis of acne vulgaris to anti-acne agents.

Arch Dermatol Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis. Four factors play vital roles in acne pathophysiology: hyperseborrhea and dysseborrhea, altered keratinization of the pilosebaceous duct, Cutibacterium acnes (C. acnes) and inflammation. Read More

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http://dx.doi.org/10.1007/s00403-019-01908-xDOI Listing
March 2019
3 Reads

Modulation of lipid fluidity likely contributes to the fructose/xylitol-induced acceleration of epidermal permeability barrier recovery.

Arch Dermatol Res 2019 May 7;311(4):317-324. Epub 2019 Mar 7.

Shiseido Global Innovation Center, Yokohama, Japan.

We previously showed that topical application of hexoses such as fructose accelerates barrier recovery after disruption. We also showed that various hexoses and polyols interact with phospholipid and alter the phase transition temperature. Thus, we hypothesized that the improvement of barrier recovery by hexoses and polyols might be related to the interaction with phospholipid. Read More

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http://dx.doi.org/10.1007/s00403-019-01905-0DOI Listing

Association of GA genotype of SNP rs4680 in COMT gene with psoriasis.

Arch Dermatol Res 2019 May 6;311(4):309-315. Epub 2019 Mar 6.

University Diagnostic Laboratory, LLC, Moscow, Russia.

Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. Read More

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http://dx.doi.org/10.1007/s00403-019-01904-1DOI Listing
May 2019
6 Reads

Malondialdehyde, lipoprotein-a, lipoprotein ratios, comprehensive lipid tetrad index and atherogenic index as surrogate markers for cardiovascular disease in patients with psoriasis: a case-control study.

Arch Dermatol Res 2019 May 4;311(4):287-297. Epub 2019 Mar 4.

Department of Dermatology, Venereology and Leprosy, Dr. R. P. GovKangrat. Medical College, Kangra, (Tanda), Himachal Pradesh, 176001, India.

Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atherogenic index (AI), and evaluated cardiovascular risk in 132 (M:F 94:38) patients with psoriasis aged 20-79 years with chronic plaque psoriasis and equal number of age and gender-matched controls. Lipoprotein ratios, CLTI and AI were calculated using standard formulae. Read More

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http://dx.doi.org/10.1007/s00403-019-01896-yDOI Listing
May 2019
2 Reads

Malondialdehyde and advanced oxidation protein products are not increased in psoriasis: a controlled study.

Arch Dermatol Res 2019 May 4;311(4):299-308. Epub 2019 Mar 4.

Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norway.

This study investigated oxidative stress in patients with psoriasis of low and medium disease activity. We measured advanced oxidation protein products (AOPP) and malondialdehyde (MDA) in plasma using UV-spectrophotometry and high performance liquid chromatography connected to a fluorescence detector in 84 patients and 84 matched healthy subjects. AOPP is a marker of protein oxidation due to inflammation, whereas MDA is a hydroxyl radical initiated lipid peroxidation product. Read More

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http://dx.doi.org/10.1007/s00403-019-01903-2DOI Listing
May 2019
2 Reads

HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population.

Arch Dermatol Res 2019 May 2;311(4):277-285. Epub 2019 Mar 2.

Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, China.

To verify whether PsA-associated HLA alleles proposed in other populations are also related to PsA in Chinese Han population, a study of PsA susceptible alleles in the HLA-A, HLA-B, HLA-C and HLA-DRB1 alleles was presented for Chinese Han population. Genotyping was performed by Illumina Miseq platform (Illumina, USA). 50 subtypes and 77 subtypes of HLA-A, HLA-B, HLA-C and HLA-DRB1 with minor allele frequency (MAF) > 1% were genotyped from two-digit and four-digit resolution analysis in 111 PsA and 207 HCs (healthy controls) collected from Chinese Han population, respectively. Read More

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http://dx.doi.org/10.1007/s00403-019-01902-3DOI Listing
May 2019
2 Reads

Understanding the basis of Ehlers-Danlos syndrome in the era of the next-generation sequencing.

Arch Dermatol Res 2019 May 2;311(4):265-275. Epub 2019 Mar 2.

Regional Center of Ehlers-Danlos Syndrome, IRCCS Ca' Granda Foundation, Via San Barnaba 8, Milan, Italy.

Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of heritable connective tissue disorders (HCTDs) defined by joint laxity, skin alterations, and joint hypermobility. The latest EDS classification recognized 13 subtypes in which the clinical and genetic phenotypes are often overlapping, making the diagnosis rather difficult and strengthening the importance of the molecular diagnostic confirmation. New genetic techniques such as next-generation sequencing (NGS) gave the opportunity to identify the genetic bases of unresolved EDS types and support clinical counseling. Read More

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http://link.springer.com/10.1007/s00403-019-01894-0
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http://dx.doi.org/10.1007/s00403-019-01894-0DOI Listing
May 2019
9 Reads

The role of adipokines in systemic sclerosis: a missing link?

Arch Dermatol Res 2019 May 26;311(4):251-263. Epub 2019 Feb 26.

Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008, Warszawa, Poland.

Systemic sclerosis is a multiorgan autoimmune disease characterized by vasculopathy and tissue fibrosis of unknown etiology. Recently, adipokines (cell signaling proteins secreted by adipose tissue) have attracted much attention as a cytokine family contributing to the various pathological processes of systemic sclerosis. Adipokines, such as leptin, adiponectin, resistin, adipsin, visfatin or chemerin are a heterogenic group of molecules. Read More

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http://dx.doi.org/10.1007/s00403-019-01893-1DOI Listing

Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity.

Arch Dermatol Res 2019 Apr 23;311(3):141-162. Epub 2019 Feb 23.

School of Life Sciences, University of Nottingham, Life Sciences Building, University Park, Nottingham, NG7 2RD, UK.

Atopic dermatitis (AD) is a widespread condition that appears to be increasing in prevalence and severity worldwide, yet the underlying mechanisms are not well understood. Recent research has identified various similarities between AD and autoimmune conditions, as well as indicating that there may be an association between AD and autoimmunity. This systematic review evaluates the association between AD and autoimmunity, as well as between severity of disease in AD and autoimmunity, with an emphasis on the associations with autoantibodies. Read More

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http://dx.doi.org/10.1007/s00403-019-01890-4DOI Listing

Nestin progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo.

Arch Dermatol Res 2019 May 23;311(4):325-330. Epub 2019 Feb 23.

Monasterium Laboratory, Muenster, Germany.

The combination of an aging population and an increasing prevalence of diseases associated with impaired-wound healing, including obesity, peripheral vascular disease and diabetes, is likely to result in a dramatic increase in the incidence and prevalence of chronic skin wounds. Indeed, systemic reviews are now not only trying to establish both the prevalence and the often under-estimated socio-economic costs of chronic skin wounds, but most importantly are addressing the impact that chronic wounds have on quality of life. Given the clear need for novel approaches to the management of chronic skin ulceration, ideally developed and tested in the human system in a manner that can be rapidly translated into clinical practice, we examined the effects of multipotent primary human nestin progenitor cells on human wound healing in an ex vivo model. Read More

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http://dx.doi.org/10.1007/s00403-019-01889-xDOI Listing

Willingness to pay and quality of life in patients with pruritic skin disorders.

Arch Dermatol Res 2019 Apr 20;311(3):221-230. Epub 2019 Feb 20.

Department of Dermatology, University Hospital of Heraklion, 71110, Crete, Greece.

Pruritic dermatosis is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and the health-related quality of life (HRQoL) in patients with pruritic dermatoses and (2) to compare the results with data on socio-demographic data, and clinical features/symptoms of the patients. One hundred and three patients with pruritic dermatosis had participated in a non-interventional, cross-sectional study. Read More

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http://dx.doi.org/10.1007/s00403-019-01900-5DOI Listing
April 2019
1 Read

Cytidine decreases melanin content in a reconstituted three-dimensional human epidermal model.

Arch Dermatol Res 2019 Apr 20;311(3):249-250. Epub 2019 Feb 20.

Department of Dermatology, Yale School of Medicine, New Haven, CT, 06520-8059, USA.

The process of melanin biosynthesis and its distribution throughout the skin is regulated by complex processes involving several enzymes in melanocytes. Recently, Diwakar et al. demonstrated that cytidine-a sialyltransferase inhibitor, 6'-sialyllactose (6'-SL) and 3'-sialyllactose (3'-SL) inhibited melanogenesis and melanosome transfer process. Read More

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http://dx.doi.org/10.1007/s00403-019-01897-xDOI Listing

Clinical purpura and elastosis and their correlation with skin tears in an aged population.

Arch Dermatol Res 2019 Apr 20;311(3):231-247. Epub 2019 Feb 20.

School of Public Health, Curtin University, Kent St, Bentley, WA, 6102, Australia.

The previous research reported the results of a prospect cohort study that used logistic regression analysis to construct a risk prediction model for skin tears in individuals aged over 65 years. The model identified three baseline individual characteristics (male gender, history of STs, and history of falls) and two baseline skin manifestations (purpura and elastosis) that predicted the risk of dorsal forearm skin tears. This paper outlines the relationships between baseline skin manifestations and the risk of skin tears. Read More

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http://link.springer.com/10.1007/s00403-019-01899-9
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http://dx.doi.org/10.1007/s00403-019-01899-9DOI Listing
April 2019
4 Reads

Rutin and ascorbic acid cooperation in antioxidant and antiapoptotic effect on human skin keratinocytes and fibroblasts exposed to UVA and UVB radiation.

Arch Dermatol Res 2019 Apr 19;311(3):203-219. Epub 2019 Feb 19.

Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Białystok, Poland.

The combination of ascorbic acid and rutin is frequently used in oral preparations. However, despite numerous protective effects of each component individually, their combined effect on ultraviolet (UV)-irradiated skin cells has never been evaluated. The aim of this study was to evaluate the combined effect of ascorbic acid and rutin on human keratinocytes and fibroblasts exposed to UVA and UVB radiation. Read More

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http://link.springer.com/10.1007/s00403-019-01898-w
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http://dx.doi.org/10.1007/s00403-019-01898-wDOI Listing
April 2019
7 Reads

Activators of SIRT1 in wound repair: an animal model study.

Arch Dermatol Res 2019 Apr 19;311(3):193-201. Epub 2019 Feb 19.

Graduate Program in Biomedical Sciences, Centro Universitário da Fundação Hermínio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitário, Araras, SP, 13607-339, Brazil.

Caloric restriction (CR) and resveratrol activate SIRT1 and induce anti-inflammatory and antioxidant properties. We perform excisional lesion on the dorsum of four groups anesthetized animals: ad libitum-AL diet, AL diet with topical application of 2% resveratrol-Rv, 30% calorie restricted, and finally 30% calorie restricted with 2% resveratrol and we examine CR and Rv effects in wound repair. Restricted animals remained with CR for 31 days. Read More

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http://dx.doi.org/10.1007/s00403-019-01901-4DOI Listing

Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.

Arch Dermatol Res 2019 Apr 18;311(3):183-191. Epub 2019 Feb 18.

Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.

Little is known about the anti-pigmenting effects of whitening agents on solar lentigos (SLs), which comprise ~ 60% of hyperpigmented facial lesions of Asian subjects. Lotions with or without 6% L-ascorbate-2-phosphate trisodium salt (APS) [test lotion (TL) and placebo lotion (PL), respectively] were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs on both sides of their faces. Pigmentation scores were evaluated using a photo-scale and the skin colors were assessed using a color difference meter and a mexameter for SLs and the non-lesional surrounding skin (NLS). Read More

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http://dx.doi.org/10.1007/s00403-019-01892-2DOI Listing
April 2019
1 Read

Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march.

Arch Dermatol Res 2019 Apr 15;311(3):173-182. Epub 2019 Feb 15.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age). Read More

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http://dx.doi.org/10.1007/s00403-019-01895-zDOI Listing
April 2019
2 Reads

Meta-analysis and prioritization of human skin pigmentation-associated GWAS-SNPs using ENCODE data-based web-tools.

Arch Dermatol Res 2019 Apr 13;311(3):163-171. Epub 2019 Feb 13.

Department of Genetics, University of Calcutta, Kolkata, India.

Skin pigmentation in human is a complex trait, which varies widely, both within and between human populations. The exact players governing the trait of skin pigmentation remain elusive till date. Various Genome Wide Association Studies (GWAS) have shown the association of different genomic variants with normal human skin pigmentation, often indicating genes with no direct implications in melanin biosynthesis or distribution. Read More

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http://dx.doi.org/10.1007/s00403-019-01891-3DOI Listing
April 2019
2.270 Impact Factor

Treponema pallidum induces the activation of endothelial cells via macrophage-derived exosomes.

Arch Dermatol Res 2019 Mar 2;311(2):121-130. Epub 2019 Feb 2.

Department of Dermatology, Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, 214002, China.

Recent studies have shown that exosomes play a role in pathogenesis and in the treatment of inflammatory diseases and tumours. We explored the effects of Treponema pallidum-induced macrophage-derived exosomes on vascular endothelial cells to determine whether they are involved in the pathogenesis of syphilis. A syphilis infection model was established using rabbits to harvest T. Read More

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http://link.springer.com/10.1007/s00403-018-01888-4
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http://dx.doi.org/10.1007/s00403-018-01888-4DOI Listing
March 2019
8 Reads

Ameliorative effects of green tea extract from tannase digests on house dust mite antigen-induced atopic dermatitis-like lesions in NC/Nga mice.

Arch Dermatol Res 2019 Mar 7;311(2):109-120. Epub 2019 Jan 7.

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 54538, South Korea.

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which is affected by several factors. Anti-histamines, steroids, and immunosuppressive agents have been used for the treatment of AD. However, many studies have reported that long-term use and abuse of these drugs causes many side effects. Read More

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http://dx.doi.org/10.1007/s00403-018-01886-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394501PMC
March 2019
1 Read

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2019 Mar 13;311(2):99-107. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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http://link.springer.com/10.1007/s00403-018-1885-x
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http://dx.doi.org/10.1007/s00403-018-1885-xDOI Listing
March 2019
15 Reads

Comparing early and late treatments with rituximab in pemphigus vulgaris: which one is better?

Arch Dermatol Res 2019 Jan 1;311(1):63-69. Epub 2018 Dec 1.

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.

During the last decade, successfully treatment of patients diagnosed with pemphigus vulgaris (PV) with rituximab (RTX) was reported by several authors. The present study has been designed to compare the clinical outcomes and RTX-related side effects between the two groups of early treated (≤ 6 months) and lately treated PV (> 6 months) patients with RTX. We did a retrospective study between Oct 2014 and Jun 2016 to compare the short-term efficacy and safety of RTX in PV diagnosed patients. Read More

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http://link.springer.com/10.1007/s00403-018-1881-1
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http://dx.doi.org/10.1007/s00403-018-1881-1DOI Listing
January 2019
19 Reads

Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model.

Arch Dermatol Res 2019 Mar 30;311(2):131-140. Epub 2018 Nov 30.

Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyunggi-do, 16419, Republic of Korea.

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. Read More

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http://dx.doi.org/10.1007/s00403-018-1883-zDOI Listing
March 2019
10 Reads

Downregulation of aquaporin 3 in bullous pemphigoid patients.

Arch Dermatol Res 2019 Mar 4;311(2):93-97. Epub 2018 Dec 4.

Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al Manial, Cairo, 11956, Egypt.

Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Read More

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http://dx.doi.org/10.1007/s00403-018-1884-yDOI Listing
March 2019
7 Reads

Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development.

Arch Dermatol Res 2019 Jan 3;311(1):71-82. Epub 2018 Dec 3.

Department of Dermatology, Kyorin University School of Medicine, 6-20-2, Shinkawa Mitaka, Tokyo, 181-8611, Japan.

No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Read More

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http://dx.doi.org/10.1007/s00403-018-1882-0DOI Listing
January 2019
3 Reads

CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration.

Arch Dermatol Res 2019 Jan 27;311(1):55-62. Epub 2018 Nov 27.

Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, Japan.

Melanocyte stem cells (McSCs) are localized in the bulge region of hair follicles and supply melanocytes, which determine hair color by synthesizing melanin. Ectopic differentiation of McSCs, which are usually undifferentiated in the bulge region, causes depletion of McSCs and results in hair graying. Therefore, to prevent hair graying, it is essential to maintain McSCs in the bulge region, but the mechanism of McSC maintenance remains unclear. Read More

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http://dx.doi.org/10.1007/s00403-018-1880-2DOI Listing
January 2019
5 Reads

The role of PI3K/AKT/FOXO signaling in psoriasis.

Arch Dermatol Res 2019 Mar 27;311(2):83-91. Epub 2018 Nov 27.

Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.

Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathway play a central role in multiple cellular functions such as cell proliferation and survival. The forkhead box O (FOXO) transcription factors are negatively regulated by the PI3K/AKT signaling pathway and considered to have inhibitory effect on cell proliferation. Psoriasis is a multifactorial disease with a strong genetic background and characterized by hyperproliferative keratinocyte. Read More

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http://dx.doi.org/10.1007/s00403-018-1879-8DOI Listing
March 2019
2 Reads

Podoplanin suppresses the cell adhesion of epidermal keratinocytes via functional regulation of β1-integrin.

Arch Dermatol Res 2019 Jan 20;311(1):45-53. Epub 2018 Nov 20.

Department of Dermatology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan.

Epidermal stem cells adhere more efficiently to the extracellular matrix (ECM) than the less adhesive differentiating cells due to their high expression of cell adhesion molecules including β1-integrin. Podoplanin is majorly expressed in the markedly proliferative and differentiating basal cells of the wounded and psoriatic epidermis. This study was designed to reveal podoplanin's function in human epidermal keratinocytes (HEK) focusing on its interaction with β1-integrin. Read More

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http://dx.doi.org/10.1007/s00403-018-1878-9DOI Listing
January 2019
2 Reads

Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma.

Arch Dermatol Res 2019 Jan 20;311(1):37-43. Epub 2018 Nov 20.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.

The cellular origin of Merkel cell carcinoma (MCC) is controversial. We previously hypothesized that MCC originates from hair follicle stem cells or Merkel cell (MC) progenitors residing within the hair follicle bulge. Examination of three cases of combined MCC led to the unexpected discovery that numerous keratin 20 (CK20)-positive MCs within the squamous cell carcinoma (SCC) component of combined MCC appeared morphologically normal with dendritic and oval shapes. Read More

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http://dx.doi.org/10.1007/s00403-018-1877-xDOI Listing
January 2019
7 Reads

A randomized placebo-controlled single-center pilot study of the safety and efficacy of apremilast in subjects with moderate-to-severe alopecia areata.

Arch Dermatol Res 2019 Jan 11;311(1):29-36. Epub 2018 Nov 11.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alopecia areata (AA) is a common autoimmune disease that results in non-scarring hair loss. AA pathogenesis is thought to involve multiple inflammatory cytokines. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that reduces pro-inflammatory cytokine production. Read More

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http://dx.doi.org/10.1007/s00403-018-1876-yDOI Listing
January 2019
5 Reads

Gene expression analysis of antimony resistance in Leishmania tropica using quantitative real-time PCR focused on genes involved in trypanothione metabolism and drug transport.

Arch Dermatol Res 2019 Jan 2;311(1):9-17. Epub 2018 Nov 2.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Pentavalent antimonials remain the treatment of choice for all the clinical forms of leishmaniasis. The increasing rates of antimony resistance are becoming a serious health problem in treatment of anthroponotic cutaneous leishmaniasis (ACL). Accordingly, unraveling molecular markers is crucial for improving medication strategies and monitoring of drug-resistant parasites. Read More

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http://link.springer.com/10.1007/s00403-018-1872-2
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http://dx.doi.org/10.1007/s00403-018-1872-2DOI Listing
January 2019
3 Reads

Mortality and risk factors among Israeli bullous pemphigoid patients.

Arch Dermatol Res 2019 Jan 31;311(1):19-27. Epub 2018 Oct 31.

Department of Dermatology, Emek Medical Center, Afula, Israel.

There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Read More

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http://link.springer.com/10.1007/s00403-018-1875-z
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http://dx.doi.org/10.1007/s00403-018-1875-zDOI Listing
January 2019
7 Reads

Small intestinal bacterial overgrowth in systemic sclerosis: a review of the literature.

Arch Dermatol Res 2019 Jan 31;311(1):1-8. Epub 2018 Oct 31.

Chair and Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland.

Systemic sclerosis (SSc) is a chronic, connective tissue disease with an autoimmune pattern characterized by inflammation, fibrosis and microcirculation changes leading to internal organs malfunctions. Recently, the presence of uncharacteristic gastrointestinal symptoms in the course of SSc has been underlined. The possible cause of such clinical presentation is the small intestinal bacterial overgrowth (SIBO). Read More

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http://link.springer.com/10.1007/s00403-018-1874-0
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http://dx.doi.org/10.1007/s00403-018-1874-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326989PMC
January 2019
4 Reads

Reconstructed human keloid models show heterogeneity within keloid scars.

Arch Dermatol Res 2018 Dec 28;310(10):815-826. Epub 2018 Oct 28.

Department of Molecular Cell Biology and Immunology, O|2 Lab Building, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions. Read More

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http://dx.doi.org/10.1007/s00403-018-1873-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244653PMC
December 2018
3 Reads

Benefits of a membership in a psoriasis patient organisation: a quasi-experimental longitudinal study.

Arch Dermatol Res 2018 Dec 22;310(10):807-813. Epub 2018 Oct 22.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

Background And Objectives: Patient organisations play an important role in supporting patients with chronic diseases and allow information transfer beyond professional care structures. Until now, only few studies have investigated the benefits of a dermatological patient organisation. In this study, potential benefits of joining the German Psoriasis Association (Deutscher Psoriasis Bund e. Read More

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http://link.springer.com/10.1007/s00403-018-1869-x
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http://dx.doi.org/10.1007/s00403-018-1869-xDOI Listing
December 2018
18 Reads

Topical treatment with the bacterium-derived c-Met agonist InlB/15 accelerates healing in the abrasion wound mouse model.

Arch Dermatol Res 2018 Dec 10;310(10):849-856. Epub 2018 Oct 10.

Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.

Studies of factors affecting wound-healing rates are encouraged by a critical need for new treatments to manage an increasing burden of non-healing wounds. The InlB protein produced by the Gram-positive bacterium Listeria monocytogenes is an agonist of the tyrosine kinase receptor c-Met and a functional analog of the hepatocyte growth factor (HGF), which is a mammalian ligand of c-Met. The recombinant InlB protein, which is the c-Met-binding InlB domain (amino acids 31-321), was cloned from the L. Read More

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http://link.springer.com/10.1007/s00403-018-1870-4
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http://dx.doi.org/10.1007/s00403-018-1870-4DOI Listing
December 2018
6 Reads

Inflammatory reaction, clinical efficacy, and safety of bacterial cellulose wound dressing containing silk sericin and polyhexamethylene biguanide for wound treatment.

Arch Dermatol Res 2018 Dec 9;310(10):795-805. Epub 2018 Oct 9.

Bioactive Resources for Innovative Clinical Applications Research Unit, Chulalongkorn University, Bangkok, Thailand.

Bacterial cellulose wound dressings containing silk sericin and PHMB (BCSP) were developed in our previous studies. It had good physical properties, efficacy, and safety. For further use as a medical material, this dressing was investigated for its efficacy and safety in split-thickness skin graft (STSG) donor-site wound treatment compared to Bactigras® (control). Read More

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http://link.springer.com/10.1007/s00403-018-1871-3
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http://dx.doi.org/10.1007/s00403-018-1871-3DOI Listing
December 2018
5 Reads

Visfatin and insulin levels and cigarette smoking are independent risk factors for hidradenitis suppurativa: a case-control study.

Arch Dermatol Res 2018 Dec 6;310(10):785-793. Epub 2018 Oct 6.

Department of Medical Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS. Read More

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http://link.springer.com/10.1007/s00403-018-1867-z
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http://dx.doi.org/10.1007/s00403-018-1867-zDOI Listing
December 2018
8 Reads

Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice.

Arch Dermatol Res 2018 Dec 5;310(10):843-848. Epub 2018 Oct 5.

Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.

Many hair loss disorders, including non-scaring alopecia, are caused by the arrest of hair follicles at the telogen phase, and the failure to enter the growth phase. Several studies report the efficacy of tofacitinib in promoting hair growth, by mechanisms not precisely known. The aim of this study was to identify other mechanisms by which tofacitinib, applied topically, promotes hair growth. Read More

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http://link.springer.com/10.1007/s00403-018-1868-y
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http://dx.doi.org/10.1007/s00403-018-1868-yDOI Listing
December 2018
2 Reads

Systematic review of mobile phone-based teledermatology.

Arch Dermatol Res 2018 Nov 24;310(9):675-689. Epub 2018 Sep 24.

Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.

Teledermatology is an expanding field within dermatology that has grown and become more clinically accepted by both patients and doctors. With approximately 260 million mobile phone users in the US and 4-6 billion worldwide with access to mobile phones, teledermatology serves as a potentially useful tool for diagnosis and management (Samkange-Zeeb and Blettner in Emerg Health Threats J, https://doi.org/10. Read More

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http://link.springer.com/10.1007/s00403-018-1862-4
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http://dx.doi.org/10.1007/s00403-018-1862-4DOI Listing
November 2018
9 Reads

Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?

Arch Dermatol Res 2018 Dec 22;310(10):833-841. Epub 2018 Sep 22.

Centre for Dermatology Research, University of Manchester, Manchester, UK.

Chronic wounds remain a major unmet healthcare challenge, associated with substantial morbidity and economic costs. Therefore, novel treatment strategies and therapeutic approaches need to be urgently developed. Yet, despite the increasingly recognized importance of neurohormonal signaling in skin physiology, the neuroendocrine regulation of cutaneous wound healing has received surprisingly little attention. Read More

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http://dx.doi.org/10.1007/s00403-018-1864-2DOI Listing
December 2018
2 Reads