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    4055 results match your criteria Archives of Dermatological Research[Journal]

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    Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia.
    Arch Dermatol Res 2018 Mar 16. Epub 2018 Mar 16.
    Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
    Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. Read More

    Autologous platelet-rich plasma and triamcinolone acetonide intralesional injection in the treatment of oral erosions of pemphigus vulgaris: a pilot study.
    Arch Dermatol Res 2018 Mar 10. Epub 2018 Mar 10.
    Department of Dermatology, Cairo University School of Medicine, Kasr Al Ainy hospital, Al-Manial, Cairo, PO 11956, Egypt.
    Oral erosions of pemphigus vulgaris (PV) represent a therapeutic challenge. In this work we compared intralesional injection of steroids (ILS) and autologous platelet-rich plasma (PRP) treatment of oral erosions of PV. In this split-mouth randomized double blind study, one side of the buccal mucosa of 11 PV patients was injected with 10 mg/ml triamcinolone and the opposite side was injected with 1 millilitre of autologous PRP every 14 days for 3 months. Read More

    IL-17 inhibition: is it the long-awaited savior for alopecia areata?
    Arch Dermatol Res 2018 Mar 1. Epub 2018 Mar 1.
    International Hair Research Foundation (IHRF), Milan, Italy.
    Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available information on the connection between AA and IL-17 is described. Read More

    Effects of topical topiramate in wound healing in mice.
    Arch Dermatol Res 2018 Feb 23. Epub 2018 Feb 23.
    Nursing School, University of Campinas, Campinas, SP, 13084-970, Brazil.
    Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6. Read More

    Leptin regulates the pro-inflammatory response in human epidermal keratinocytes.
    Arch Dermatol Res 2018 Feb 21. Epub 2018 Feb 21.
    College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
    The role of leptin in cutaneous wound healing process has been suggested in genetically obese mouse studies. However, the molecular and cellular effects of leptin on human epidermal keratinocytes are still unclear. In this study, the whole-genome-scale microarray analysis was performed to elucidate the effect of leptin on epidermal keratinocyte functions. Read More

    Effect of Dickkopf1 on the senescence of melanocytes: in vitro study.
    Arch Dermatol Res 2018 Feb 13. Epub 2018 Feb 13.
    Department of Zoology, Panjab University, Chandigarh, 160014, India.
    Fibroblasts secrete several growth factors which are important for the regulation of skin pigmentation. Dickkopf1 (DKK1) is also secreted by fibroblasts which inhibit the growth and function of melanocytes. Therefore, the study was designed to check the role of DKK1 in vitiligo pathogenesis. Read More

    Treatment preferences and treatment satisfaction among psoriasis patients: a systematic review.
    Arch Dermatol Res 2018 Feb 13. Epub 2018 Feb 13.
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    A critical gap exists in determining treatment preferences and treatment satisfaction from patient perspectives, which is paramount to achieving therapeutic success. The objective of this systematic review is to determine factors influencing treatment preferences and treatment satisfaction among psoriasis patients. PubMed, EMBASE, and Web of Science databases were searched between November 1, 2010, and December 1, 2017. Read More

    BPDAI and ABSIS correlate with serum anti-BP180 NC16A IgG but not with anti-BP230 IgG in patients with bullous pemphigoid.
    Arch Dermatol Res 2018 Apr 8;310(3):255-259. Epub 2018 Feb 8.
    Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.
    Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by autoantibody production against BP180 and BP230. Two scoring systems have been validated for BP including: Bullous Pemphigoid Disease Area Index (BPDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). In this study, we investigated correlations between both scoring systems and either anti-BP180 NC16A or anti-BP230 values. Read More

    Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
    Arch Dermatol Res 2018 Feb 7. Epub 2018 Feb 7.
    Department of Dermatology, Venereology and Allergology, HELIOS-Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Germany.
    The histopathologic differentiation between Spitz nevus and melanoma is of particular interest in routine diagnostic procedures of melanocytic tumors. Atypical Spitz nevi are sometimes difficult to distinguish from melanoma. There is still no single criterion that ensures a distinction of melanoma and atypical Spitz nevus. Read More

    Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia.
    Arch Dermatol Res 2018 Feb 3. Epub 2018 Feb 3.
    Department of Dermatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
    The late cornified envelope (LCE) gene cluster is located on chromosome 1q21, including LCE1-LCE6. Several single nucleotide polymorphisms (SNPs) in the LCE cluster were associated with susceptibility to psoriasis in Chinese population. However, there is no report on the relationship in ethnic minority areas in China. Read More

    Subcutaneous injection of multipotent mesenchymal stromal cells admixed with melanoma cells in mice favors tumor incidence and growth: a systematic review and meta-analysis.
    Arch Dermatol Res 2018 Apr 3;310(3):231-240. Epub 2018 Feb 3.
    Programa de Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande (FURG), Av Itália, Km 8, Rio Grande, RS, 96210-900, Brazil.
    Multipotent mesenchymal stem/stromal cells (MSCs) have strong tropism towards cancer cells, thus being tested as tools for the targeted delivery of therapeutic substances for the treatment of melanoma. However, different experimental approaches for melanoma induction and MSC treatment can have a direct impact on the outcomes. Systematic search was carried out in three databases (PubMed, Scopus, and Web of Science) to include all studies, where stem cells were used as intervention for animal models for melanoma. Read More

    Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D.
    Arch Dermatol Res 2018 Apr 1;310(3):221-230. Epub 2018 Feb 1.
    Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Perth, WA, 6008, Australia.
    Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and regulatory T (T) cells. 1,25(OH)D also promotes immunoregulation by mast cells, and inhibits the development of T helper type-9 (Th9) cells that secrete interleukin-9 (IL-9). Here, we investigated the ability of topical 1,25(OH)D to suppress contact dermatitis through an IL-9-dependent process, examining mast cells and IL-9-secreting T cells. Read More

    Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients.
    Arch Dermatol Res 2018 Apr 24;310(3):209-220. Epub 2018 Jan 24.
    Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
    Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cells against basal epithelial cells. MicroRNAs (MiRNAs) are short non-coding RNA that plays critical role in gene expression at post-transcriptional levels. Much evidence showed that miRNAs play an important role in regulating immune response and cancer development. Read More

    Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis.
    Arch Dermatol Res 2018 Apr 24;310(3):197-207. Epub 2018 Jan 24.
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
    The Stat6VT mouse model of atopic dermatitis (AD) is induced by T-cell-specific expression of a constitutively active form of the protein signal transducer and activator of transcription 6 (STAT6). Although AD-like lesions are known to develop in Stat6VT mice, this study was designed to determine if these mice develop acute and chronic phases of disease similar to humans. To address this, AD-like lesions from Stat6VT mice were harvested at two different timepoints relative to their onset. Read More

    Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis.
    Arch Dermatol Res 2018 Jan 23. Epub 2018 Jan 23.
    The Children's Hospital, Zhejiang University School of Medicine, No. 3333 Binsheng Road, Hangzhou, 310052, Zhejiang, China.
    A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results. The present study assessed the response rate and adverse events of topical timolol in the treatment of infantile hemangioma. Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and Cochrane library were searched until October 2016. Read More

    The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis.
    Arch Dermatol Res 2018 Apr 23;310(3):187-196. Epub 2018 Jan 23.
    Center for Bioscience Research and Education, Utsunomiya University, Tochigi, Japan.
    We recently found that treatment of normal human melanocytes (NHMs) with the antioxidant astaxanthin (AX) suppresses the stem cell factor (SCF)-stimulated protein expression levels of microphthalmia-associated transcription factor (MITF) at 1.5 h and of tyrosinase and endothelin B receptor at 96 h post-treatment. Analysis of the signaling cascade(s) involved revealed that although the major SCF-activated signaling cascade that leads to CREB activation (the c-KIT/Shc/Raf-1/ERK/RSK/CREB axis) is not interrupted, the increased phosphorylation of CREB is significantly abrogated by AX. Read More

    Skin depigmenting action of silkworm (Bombyx mori L.) droppings in zebrafish.
    Arch Dermatol Res 2018 Apr 22;310(3):245-253. Epub 2018 Jan 22.
    Graduate School of Biotechnology, Kyung Hee University, Global Campus, Yongin, Gyeonggi, 446-701, Republic of Korea.
    The excrement of silkworms (Bombyx mori L.), referred to here as silkworm droppings (SDs), is used as a traditional drug in eastern medicine to treat skin diseases such as urticaria and atopy. However, the depigmentation effects of SDs have not previously been evaluated. Read More

    Construction of a plasmid vector containing epidermal growth factor receptor and C-Jun shRNA.
    Arch Dermatol Res 2018 Apr 20;310(3):241-243. Epub 2018 Jan 20.
    Department of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650103, Yunnan, China.
    The objective of this study was to construct a plasmid vector for EGFR-hm-1 and C-Junh-825 small interfering RNA (siRNA). EGFR-hm-1 and C-Jun-hm-825 oligonucleotide fragments were synthesized and short hairpin RNA (shRNA) were amplified by PCR. Plasmids were isolated from E. Read More

    Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids.
    Arch Dermatol Res 2018 Mar 19;310(2):165-172. Epub 2018 Jan 19.
    Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Serotonin (5-hydroxytryptamine or 5-HT) is a neurotransmitter in itch and impaired serotonin signaling has been linked to a variety of itch conditions. Intradermal injection of 5-HT induces scratching behavior in mice through stimulation of 5-HT receptors. Previous studies have demonstrated that selective 5-HT1B/1D receptors agonists, including sumatriptan, inhibits neurotransmission. Read More

    Histological findings after argon plasma coagulation: an ex-vivo study revealing a possible role in superficial ablative treatment of the skin.
    Arch Dermatol Res 2018 Mar 19;310(2):157-163. Epub 2018 Jan 19.
    Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Argon plasma coagulation (APC) is an electrosurgical technique which can be used to ablate skin lesions with limited invasion depth into dermal tissue. Hence, APC might be well suited for the removal of epithelial tumours. However, there are no data on the effects of APC on human skin tissue. Read More

    Matrix metalloproteinase-2 and -9 activity levels increase in cutaneous lupus erythematosus lesions and correlate with disease severity.
    Arch Dermatol Res 2018 Mar 18;310(2):173-179. Epub 2018 Jan 18.
    Department of Dermatology and Venereology, School of Medicine, Dokuz Eylul University, 35340, Inciralti, Izmir, Turkey.
    Lupus erythematosus is a chronic autoimmune disease characterized by remissions and exacerbations. Accumulated evidence indicated that matrix metalloproteinases (MMPs) are upregulated in inflammatory cells of cutaneous lupus erythematosus (CLE); however, the activity levels of these proteases have remained uncharacterized. To elucidate the significance of MMP-2, MMP-9, and TIMP-1 in CLE pathogenesis, gelatin zymography was used to investigate pro and active levels of MMP-2 and MMP-9 in lesional and perilesional skin biopsies obtained from twenty-two CLE patients. Read More

    NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.
    Arch Dermatol Res 2018 Mar 18;310(2):147-156. Epub 2018 Jan 18.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
    Keratin-17 (K17) is a cytoskeletal protein produced by keratinocytes (KCs), which is overexpressed in psoriasis and may play a pivotal role in its pathogenesis. Narrow-band ultraviolet B (NB-UVB) irradiation is used as a general treatment for psoriasis, although its impact on K17 expression has yet to be determined. In this study, we aimed to investigate the effect of NB-UVB irradiation on K17 expression and its signaling pathways. Read More

    Inate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study.
    Arch Dermatol Res 2018 Mar 12;310(2):139-146. Epub 2018 Jan 12.
    Department of Dermatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, sala 3021, 05403-000, São Paulo, Brazil.
    Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Read More

    Increased senescent CD8+ T cells in the peripheral blood mononuclear cells of Behçet's disease patients.
    Arch Dermatol Res 2018 Mar 18;310(2):127-138. Epub 2017 Dec 18.
    Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
    Behçet's disease (BD) is a chronic inflammatory disease characterized by recurrent mucocutaneous, ocular, and skin lesions. Immunosenescence is associated with increased susceptibility to infection and chronic low grade inflammation. This study aimed to investigate the differences in the frequencies of immunosenescent cells in the peripheral blood mononuclear cells (PBMCs) of patients with BD. Read More

    Co-culture of human fibroblasts and Borrelia burgdorferi enhances collagen and growth factor mRNA.
    Arch Dermatol Res 2018 Mar 6;310(2):117-126. Epub 2017 Dec 6.
    Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, 8036, Graz, Austria.
    Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. Read More

    DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts.
    Arch Dermatol Res 2018 Mar 4;310(2):107-115. Epub 2017 Dec 4.
    Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, No. 57, South people Road, Zhanjiang, 524001, Guangdong, China.
    The excessive growth of fibroblasts in keloid is closely related to the status of gene methylation. The aim of this project was to study whether keloid development is related to DNA methylation in the CDC2L1 gene promoter region. DNA methylation of the promoter of this gene was analyzed by bisulfite sequencing and verified by DNA methylation-specific polymerase chain reaction. Read More

    5α-Reductase isozymes and aromatase mRNA levels in plucked hair from young women with female pattern hair loss.
    Arch Dermatol Res 2018 Jan 28;310(1):77-83. Epub 2017 Nov 28.
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda. de la Investigación, 18016, Granada, Spain.
    Female pattern hair loss (FPHL) is an important hair disorder, especially when young women are affected. However, pharmacological treatments are not successful in all women. Androgens, especially dihydrotestosterone (DHT), may play a role in FPHL, but many women with this disorder have normal serum androgen levels. Read More

    Mediterranean diet: fresh herbs and fresh vegetables decrease the risk of Androgenetic Alopecia in males.
    Arch Dermatol Res 2018 Jan 27;310(1):71-76. Epub 2017 Nov 27.
    Medical Direction, Istituto Dermopatico dell'Immacolata (IDI-IRCCS-FLMM), Rome, Italy.
    It is well established that Androgenetic Alopecia (AGA) occurs in genetically predisposed individuals but little is known of its non-genetic risk factors. The aim of the study was to investigate the role of the Mediterranean diet in determining the risk of AGA. A hospital-based case-control study was conducted in the outpatient clinics of the hospital "Istituto Dermopatico dell'Immacolata, Rome, Italy". Read More

    The role of dermoscopy in the diagnosis of distal lateral subungual onychomycosis.
    Arch Dermatol Res 2018 Jan 24;310(1):57-69. Epub 2017 Nov 24.
    Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
    Recently dermoscopic patterns, that can be useful in the diagnosis of distal and lateral subungual onychomycosis, were identified. In this study, we aimed to determine the frequency of the defined patterns so far and additionally to identify other patterns that were observed and to investigate the place of these patterns in the diagnosis of Distal Lateral Subungual Onychomycosis (DLSO) in the dermoscopic examination of the patients with pre-diagnosis of DLSO. Patients admitted dermatology outpatient clinic of Haydarpasa Numune Training and Research Hospital with the complaint of nail disturbance suspicious for DLSO (97 patients) between the August 2015 and February 2016. Read More

    Skin barrier and microbiome in acne.
    Arch Dermatol Res 2018 Apr 17;310(3):181-185. Epub 2017 Nov 17.
    Federal University of São Paulo (Escola Paulista de Medicina-Universidade Federal de São Paulo), Rua Eugenio Bettarello 55 ap 134B, São Paulo, SP, Brazil.
    Acne is an immune-mediated chronic inflammatory disease. Although several factors are involved in its pathophysiology, this process is not completely understood. Androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of Propionibacterium acnes which triggers inflammation. Read More

    Is the DLQI appropriate for medical decision-making in psoriasis patients?
    Arch Dermatol Res 2018 Jan 11;310(1):47-55. Epub 2017 Nov 11.
    Department of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.
    Dermatology Life Quality Index (DLQI) is the most commonly applied measure of health-related quality of life (HRQoL) in psoriasis patients. It is among defining criteria of moderate-to-severe psoriasis and present in treatment guidelines. Our objective was to estimate preference-based HRQoL values (i. Read More

    Expression of Janus Kinase 1 in vitiligo & psoriasis before and after narrow band UVB: a case-control study.
    Arch Dermatol Res 2018 Jan 10;310(1):39-46. Epub 2017 Nov 10.
    , Cairo, Egypt.
    Janus kinases (JAKs) are non-receptor protein tyrosine kinases that are expressed in many tissues. Once the JAKs are activated, a cascade of further signaling events is triggered involving phosphorylation of selected receptor chain tyrosines, binding of signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for some skin diseases such as psoriasis and atopic dermatitis. Read More

    Quality assessment of atopic dermatitis clinical practice guidelines in ≤ 18 years.
    Arch Dermatol Res 2018 Jan 10;310(1):29-37. Epub 2017 Nov 10.
    Group of Investigative Dermatology (GRID), Universidad de Antioquia, Carrera 25 A # 1 A Sur 45, Of 2026, Torre Médica El Tesoro, Medellín, Colombia.
    Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatment options for this condition including topical and systemic regimes. Read More

    Immunohistochemical distribution of Ki67 in epidermis of thick glabrous skin of human digits.
    Arch Dermatol Res 2018 Jan 8;310(1):85-93. Epub 2017 Nov 8.
    Department of Forensic Medicine, Faculty of Medicine, University of Nis, Nis, Republic of Serbia.
    The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67. Read More

    Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.
    Arch Dermatol Res 2018 Mar 6;310(2):95-106. Epub 2017 Nov 6.
    Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. Read More

    IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review.
    Arch Dermatol Res 2018 Jan 25;310(1):11-28. Epub 2017 Oct 25.
    School of Life Sciences, University of Nottingham, Life Sciences Building, University Park, Nottingham, NG7 2RD, UK.
    Bullous pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP. Read More

    A possible implication of reduced levels of LIF, LIFR, and gp130 in vasculopathy related to systemic sclerosis.
    Arch Dermatol Res 2017 Dec 16;309(10):833-842. Epub 2017 Oct 16.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Leukemia inhibitory factor (LIF) is a member of IL-6 family, which serves as a potent chemoattractant for neutrophils as well as a potent angiostatic factor. LIF has been implicated in various autoimmune inflammatory diseases, but its role still remains elusive in systemic sclerosis (SSc). Therefore, we investigated the potential role of LIF in the development of SSc by evaluating the clinical correlation of serum LIF levels, the expression of LIF and its receptors in skin samples, and in vitro experiments with human dermal microvascular endothelial cells. Read More

    Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis.
    Arch Dermatol Res 2017 Dec 13;309(10):815-821. Epub 2017 Oct 13.
    Institute of Pathological Physiology, Charles University, Faculty of Medicine in Hradec Kralove, Simkova 870, 50038, Hradec Kralove, Czech Republic.
    Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. Read More

    Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice.
    Arch Dermatol Res 2017 Dec 12;309(10):805-813. Epub 2017 Oct 12.
    The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266001, China.
    Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized with high heterogeneity. Recent studies have suggested that it is driven by both terminal keratinocyte differentiation defects and type 2 immune responses. The mainstay steroid topical therapy has severe side effect and new treatment is in demand. Read More

    Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients.
    Arch Dermatol Res 2017 Dec 25;309(10):851-856. Epub 2017 Sep 25.
    Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.
    Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. Read More

    Adipose-derived stem cells express higher levels of type VII collagen under specific culture conditions.
    Arch Dermatol Res 2017 Dec 22;309(10):843-849. Epub 2017 Sep 22.
    Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
    Type VII collagen (Col7) is a major component of the anchoring fibrils at the dermoepidermal junction. Adipose-derived stem cells (ADSCs) are a cell population highly useful in regenerative medicine because of their ease of isolation and their potential for multilineage differentiation. Based on the observations that K14 was expressed in undifferentiated ADSCs and the expression was downregulated after differentiation into adipocytes, we speculated that ADSCs are keratinocyte stem/progenitor cells. Read More

    Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation.
    Arch Dermatol Res 2017 Dec 21;309(10):795-803. Epub 2017 Sep 21.
    Department of Chemical and Biochemical Engineering, Dongguk University, 3-26, Pil-dong, Chung-gu, Seoul, 100-715, Republic of Korea.
    Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably increased phytoceramide content in keratinocytes. Read More

    Quantity and quality of sweating in atopic dermatitis.
    Arch Dermatol Res 2017 Dec 21;309(10):787-793. Epub 2017 Sep 21.
    Department of Dermatology, Municipal Hospital Hietzing, Wolkersbergenstraße 1, 1130, Vienna, Austria.
    Sweat may be an important factor in triggering an exacerbation of atopic dermatitis. It was the aim of this study to evaluate a possible correlation between atopic patients and hyperhidrosis-measured by a questionnaire-and to find out whether there are qualitative differences in sweat response-measured by sudomotor activity (sympathetic skin response test, SSR). Included were 100 study participants, of whom 50 were patients with atopic dermatitis and 50 were serving as control group. Read More

    Dermal-epidermal separation methods: research implications.
    Arch Dermatol Res 2018 Jan 21;310(1):1-9. Epub 2017 Sep 21.
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, 94143-0989, USA.
    Dermal-epidermal separation is an important basic investigation technique for pharmacology, toxicology and biology. To choose the optimal method for a given research need, we reviewed studies on epidermal separation. PubMed, Embase, and Web of Science were utilized. Read More

    Resveratrol suppresses melanoma by inhibiting NF-κB/miR-221 and inducing TFG expression.
    Arch Dermatol Res 2017 Dec 21;309(10):823-831. Epub 2017 Sep 21.
    Department of Traditional Chinese Medicine, Daqing Oilfield General Hospital, Daqing, China.
    Resveratrol (Res) is a natural compound with anti-cancer effects. The goal of this study is to evaluate the suppression of Res in melanoma and investigate its relationship with miRNAs during this process. The in vitro and in vivo anti-cancer abilities of Res were evaluated using cellular assays and animal model. Read More

    Updated strategies for the management, pathogenesis and molecular genetics of different forms of ichthyosis syndromes with prominent hair abnormalities.
    Arch Dermatol Res 2017 Dec 14;309(10):773-785. Epub 2017 Sep 14.
    Department of Bioinformatics and Biotechnology, Maryum Block, International Islamic University Islamabad, H-10, Islamabad, 44000, Pakistan.
    Syndromic ichthyosis is rare inherited disorders of cornification with varied disease complications. This disorder appears in seventeen subtypes associated with severe systematic manifestations along with medical, cosmetic and social problems. Syndromic ichthyosis with prominent hair abnormalities covers five major subtypes: Netherton syndrome, trichothiodystrophy, ichthyosis hypotrichosis syndrome, ichthyosis hypotrichosis sclerosing cholangitis and ichthyosis follicularis atrichia photophobia syndrome. Read More

    Digestive system in psoriasis: an update.
    Arch Dermatol Res 2017 Nov 13;309(9):679-693. Epub 2017 Sep 13.
    Dermatologikum Hamburg, Hamburg, Germany.
    Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Read More

    Comparison of suction blistering and tape stripping for analysis of epidermal genes, proteins and lipids.
    Arch Dermatol Res 2017 Nov 13;309(9):757-765. Epub 2017 Sep 13.
    Department of Research and Development, Contipro a.s., Dolní Dobrouč, Czech Republic.
    Analysis of epidermal genes, proteins and lipids is important in the research and diagnosis of skin diseases. Although punch biopsy is the first-choice technique for the skin sampling, it is unnecessarily invasive for obtaining a sample just for the epidermal analysis. Here we compare two less invasive methods, suction blistering (SB) and tape stripping (TS), for the analysis of selected epidermal genes (quantitative real-time reverse transcription PCR, qRT-PCR), proteins (western blotting, WB), and lipids in ten healthy volunteers. Read More

    Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis.
    Arch Dermatol Res 2017 Nov 11;309(9):749-756. Epub 2017 Sep 11.
    Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Read More

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