29,724 results match your criteria Archives of Biochemistry and Biophysics[Journal]


Based on RNA-Seq analysis identification and expression analysis of Trans-scripusinA synthesize-related genes of UV-treatment in postharvest grape fruit.

Arch Biochem Biophys 2020 Jul 2;690:108471. Epub 2020 Jul 2.

Xi'an Key Laboratory of Characteristic Fruit Storage and Preservation, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, Shaanxi, China; Shaanxi Engineering Laboratory of Food Green Processing and Safety Control, Shaanxi Normal University, Xi'an, 710119, Shaanxi, China. Electronic address:

Stilbenes, an active substances closely related to resistance and quality of grapes, are rarely found in natural resources. However its cumulative amount is affected by ultraviolet radiation (UV). The purpose of this study is to screen key genes in biosynthesis of stilbenes Trans-scripusin A and explore its synthetic pathway. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108471DOI Listing

Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability.

Arch Biochem Biophys 2020 Jun 27:108460. Epub 2020 Jun 27.

Department of Cardiology, Nantong Third People's Hospital, Nantong, Jiangsu, 226001, China.

Background: Our previous research revealed that trypsin is abundantly expressed in atherosclerotic plaques and its distribution overlaps with that of matrix metalloproteinase-9 (MMP-9). This study was performed to explore the possible roles of trypsin in vulnerable atherosclerotic plaque formation.

Methods And Results: Twenty-four rabbits were randomly assigned to a normal (control) group, an atherosclerosis (experimental) group and a trypsin inhibitor (aprotinin) group. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108460DOI Listing

Principal component analysis of data from NMR titration experiment of uniformly N labeled amyloid beta (1-42) peptide with osmolytes and phenolic compounds.

Arch Biochem Biophys 2020 Jun 25:108446. Epub 2020 Jun 25.

Laboratory of Structural Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa-ku, Nagoya, 464-8601, Japan; Structural Biology Research Center and Division of Biological Sciences, Graduate School of Science, Nagoya University, Furocho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

A simple NMR method to analyze the data obtained by NMR titration experiment of amyloid formation inhibitors against uniformly N-labeled amyloid-β 1-42 peptide (Aβ(1-42)) was described. By using solution nuclear magnetic resonance (NMR) measurement, the simplest method for monitoring the effects of Aβ fibrilization inhibitors is the NMR chemical shift perturbation (CSP) experiment using N-labeled Aβ(1-42). However, the flexible and dynamic nature of Aβ(1-42) monomer may hamper the interpretation of CSP data. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108446DOI Listing

A 3'-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47.

Arch Biochem Biophys 2020 Jun 24:108467. Epub 2020 Jun 24.

Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, China. Electronic address:

Increasing evidence demonstrates that tRNA-derived fragments (tRFs) exert important effects and are dysregulated in various human cancer types. However, their roles in gastric cancer (GC) remain unknown. Here we identified the functional effects of tRF-3019a (derived from tRNA-Ala-AGC-1-1) in GC. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108467DOI Listing

Biomarkers of placental redox imbalance in pregnancies with preeclampsia and consequent perinatal outcomes.

Arch Biochem Biophys 2020 Jun 24:108464. Epub 2020 Jun 24.

Pós-Graduação em Nutrição/Universidade Federal de Alagoas (FANUT/UFAL), Brazil; Docente da Faculdade de Nutrição/ Universidade Federal de Alagoas (FANUT/UFAL), Brazil. Electronic address:

Objective: To compare redox and inflammatory markers between normal and PE-derived placentas and to evaluate the relationship between placental redox imbalance markers and perinatal outcomes in pregnancies with PE.

Methods: This was a cross-sectional study conducted at the maternity hospital of a university hospital in Maceio-Alagoas, Brazil, in 2017, including women diagnosed with PE and healthy pregnant women and their conceptuses. After screening, standardized questionnaires containing socioeconomic, clinical, obstetric and anthropometric data were applied. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108464DOI Listing

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor exerts greater efficacy than atorvastatin on improvement of brain function and cognition in obese rats.

Arch Biochem Biophys 2020 Jun 24;689:108470. Epub 2020 Jun 24.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

The accumulation of lipid as a result of long-term consumption of a high-fat diet (HFD) may lead to metabolic and brain dysfunction. Atorvastatin, a recommended first-line lipid-lowering agent, has shown beneficial effects on metabolic and brain functions in several models. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor was approved as an effective therapeutic drug for dyslipidemia patients. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108470DOI Listing

Conformational dynamics of p53 N-terminal TAD2 region under different solvent conditions.

Arch Biochem Biophys 2020 Jun 24;689:108459. Epub 2020 Jun 24.

School of Basic Sciences, Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh, 175005, India; BioX Centre, Indian Institute of Technology Mandi, Himachal Pradesh, India. Electronic address:

Although the mystery molecule p53 has been studied extensively, still several unknown mechanisms need to be elucidated. Being a central hub of cellular signaling pathways, the function of p53 is precisely executed synergistically by its intrinsically disordered and structural domains. The disordered N-terminal region further modulates p53 function by undergoing promiscuous binding and folding with several partners with the help of TAD1 and TAD2 motifs. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108459DOI Listing
June 2020
3.017 Impact Factor

LINC00261 inhibits progression of pancreatic cancer by down-regulating miR-23a-3p.

Arch Biochem Biophys 2020 Jun 24;689:108469. Epub 2020 Jun 24.

Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, China. Electronic address:

Long noncoding RNAs (lncRNAs) are usually dysregulated in the progression of pancreatic cancer. This research aims to explore the function and mechanism of LINC00261 in pancreatic cancer cell viability, invasion and apoptosis. Cancer Genome Atlas (TCGA) database was applied to analyze the association between survival probability of patients and level of LINC00261 or miR-23a-3p in pancreatic cancer. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108469DOI Listing

Cold atmospheric plasma induces silver nanoparticle uptake, oxidative dissolution and enhanced cytotoxicity in glioblastoma multiforme cells.

Arch Biochem Biophys 2020 Jun 23:108462. Epub 2020 Jun 23.

BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Ireland; Environmental Sustainability and Health Institute, Technological University Dublin, Ireland. Electronic address:

Silver nanoparticles (AgNP) emerged as a promising reagent for cancer therapy with oxidative stress implicated in the toxicity. Meanwhile, studies reported cold atmospheric plasma (CAP) generation of reactive oxygen and nitrogen species has selectivity towards cancer cells. Gold nanoparticles display synergistic cytotoxicity when combined with CAP against cancer cells but there is a paucity of information using AgNP, prompting to investigate the combined effects of CAP using dielectric barrier discharge system (voltage of 75 kV, current is 62. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108462DOI Listing

Dietary walnut as food factor to rescue from NSAID-induced gastrointestinal mucosal damages.

Arch Biochem Biophys 2020 Jun 23;689:108466. Epub 2020 Jun 23.

CHA Cancer Prevention Research Center, CHA Bio Complex, Pangyo, 13488, South Korea; Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, 13497, South Korea. Electronic address:

Nuclear factor erythroid-derived 2-like 2 (Nrf-2) is transcription factor implicated in the antioxidant response element-mediated induction of endogenous antioxidant enzyme such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase, and NAD(P)H quinone dehydrogenase 1, among which HO-1 is an enzyme catalyzing the degradation of heme.producing biliverdin, ferrous iron, and carbon monoxide. In the stomach, as much as regulating gastric acid secretions, well-coordinated establishment of defense system stands for maintaining gastric integrity. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108466DOI Listing

The impact of altered mechanobiology on aortic valve pathophysiology.

Arch Biochem Biophys 2020 Jun 23:108463. Epub 2020 Jun 23.

Biomedical and Nutritional Sciences, University of Massachusetts Lowell, MA, USA; Center for Population Health, University of Massachusetts Lowell, MA, USA. Electronic address:

Calcific aortic valve disease (CAVD) is the most prevalent valvulopathy worldwide. Until recently, CAVD was viewed as a passive, degenerative process and an inevitable consequence of aging. Recent improvements in disease modeling, imaging, and analysis have greatly enhanced our understanding of CAVD. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108463DOI Listing

Characterization of oxyphytosterols generated by β-sitosterol ozonization.

Arch Biochem Biophys 2020 Jun 23:108472. Epub 2020 Jun 23.

Department of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Science, Federal University of São Paulo, Rua São Nicolau, 210, Diadema, São Paulo, 09913-030, Brazil. Electronic address:

β-Sitosterol (βSito) is the most abundant phytosterol found in elevated concentrations in vegetable oils, nuts, seeds, cereals, fruits, and in many phytosterol-enriched foods. Although the benefits, there is a concern in terms of food quality and health due to the increasing consumption of phytosterols and the possible adverse side effects of their oxidation products, oxyphytosterols. βSito has a similar structure to cholesterol, with an unsaturated double bond at C5-C6, which is susceptible to oxidation by reactive oxygen species like ozone, generating oxyphytosterols. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108472DOI Listing
June 2020
3.017 Impact Factor

High-yield expression of extracellular lipase from Yarrowia lipolytica and its interactions with lipopeptide biosurfactants: A biophysical approach.

Arch Biochem Biophys 2020 Jun 23;689:108475. Epub 2020 Jun 23.

Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Wrocław, 51-630, Poland.

The unconventional yeast Yarrowia lipolytica is known as a producer of extracellular lipases. Here we overexpressed extracellular lipase (YlLip2) in yeast strain Y. lipolytica AJD ΔXΔA-Lip2 harboring the overexpression cassette of the YALI0A20350 gene under the strong hybrid promoter UAS1B-TEF. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108475DOI Listing

Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure.

Arch Biochem Biophys 2020 Jun 22;689:108473. Epub 2020 Jun 22.

Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Universidad Nacional de Córdoba - Consejo Nacional de Investigaciones Científicas y Técnicas (UNC-CONICET), Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre s/n, X5000HUA, Córdoba, Pabellón Argentina Ala Oeste, Argentina. Electronic address:

Eleven missense mutations have been describe in human triosephosphate isomerase (TPI), affecting its catalytic function. Several of these mutations generate triosephosphate isomerase deficiency, the consequences of which can in some cases be lethal. The missense F240L mutation was found in a Hungarian patient showing symptoms of chronic hemolytic anemia and neuromuscular dysfunction. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108473DOI Listing

Proteome-wide assessment of diabetes mellitus in Qatari identifies IGFBP-2 as a risk factor already with early glycaemic disturbances.

Arch Biochem Biophys 2020 Jun 22;689:108476. Epub 2020 Jun 22.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.

Background: Proteomics is expected to provide novel insights in the underlying pathophysiology of type 2 diabetes mellitus. In the present study, we aimed to identify and biochemically characterize proteins associated with diabetes mellitus in a Qatari population.

Methods: In a diabetes case-control study (175 cases, 164 controls; Arab, South Asian and Philippine ethnicities), we conducted a discovery study to screen 1141 blood protein levels for associations with diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108476DOI Listing
June 2020
3.017 Impact Factor

Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.

Arch Biochem Biophys 2020 Jun 17;689:108415. Epub 2020 Jun 17.

Tumor Biotherapy Center, Jilin Province People's Hospital, Changchun, Jilin, 130021, China. Electronic address:

Regorafenib, a multiple kinase inhibitor, is recently approved for treatment of patients with advanced hepatocellular carcinoma (HCC). Previous studies demonstrated that regorafenib was a mitochondrial toxicant, which associated with the impairment of mitochondria. Sirt3 is involved in the regulation of mitochondrial function in cancers. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108415DOI Listing

DNA demethylation increases NETosis.

Arch Biochem Biophys 2020 Jun 17;689:108465. Epub 2020 Jun 17.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minamitamagaki, Suzuka-city, Mie, 513-8670, Japan. Electronic address:

Neutrophil extracellular traps (NETs) occur during the development of autoimmune diseases, cancer and diabetes. A novel form of cell death that is induced by NETs is called NETosis. Although these diseases are known to have an epigenetic component, epigenetic regulation of NETosis has not previously been explored. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108465DOI Listing

Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved.

Arch Biochem Biophys 2020 Jun 10;689:108461. Epub 2020 Jun 10.

Department of Thyroid and Breast Surgery, Zibo Central Hospital, Zibo, 255036, China. Electronic address:

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the development of papillary thyroid cancer. While rapamycin has been shown to exhibit anti-tumor effects, it may also activate AKT, resulting in increased cell survival and drug resistance, thereby limiting its anti-tumor effects. Resveratrol can also inhibit tumor growth by regulating the PI3K/AKT/mTOR signaling pathway. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108461DOI Listing

The metal- and substrate-dependences of 2,4'-Dihydroxyacetophenone dioxygenase.

Arch Biochem Biophys 2020 Jun 9:108441. Epub 2020 Jun 9.

Department of Biology and Geology, University of South Carolina Aiken, Aiken, SC, 29801, USA. Electronic address:

While the enzyme, 2,4'-dihydroxyacetophenone dioxygenase (DAD), has been known for decades, very little has been characterized of the mechanism of the DAD-catalyzed oxidative cleavage of its reported substrate, 2,4'-dihydroxyacetophenone (DHA). The purpose of this study was to identify the active metal center and to characterize the substrate-dependence of the kinetics of the reaction to lay the foundation for deeper mechanistic investigation. To this, the DAD V1M mutant (bDAD) was overexpressed, purified, and reconstituted with various metal ions. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108441DOI Listing

Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy.

Arch Biochem Biophys 2020 Jun 8;689:108437. Epub 2020 Jun 8.

Department of Biomedical Science, BK21-plus Research Team for Bioactive Control Technology, National Research Center for Dementia, College of Natural Sciences, Chosun University, Gwangju, 61452, Republic of Korea. Electronic address:

Skin aging is influenced by several genetic, physiological, and environmental factors. In particular, ultraviolet (UV) exposure is an important factor involved in inducing skin photoaging. Autophagy controlling homeostatic balance between the synthesis, degradation, and recycling of cellular organelles and proteins plays important regulatory roles in several biological processes, including aging. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108437DOI Listing

Liver fibrogenesis: un update on established and emerging basic concepts.

Arch Biochem Biophys 2020 Jun 7;689:108445. Epub 2020 Jun 7.

University of Torino, Dept. Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical Pathology, Corso Raffaello 30, 10125, Torino, Italy.

Liver fibrogenesis is defined as a dynamic and highly integrated process occurring during chronic injury to liver parenchyma that can result in excess deposition of extracellular matrix (ECM) components (i.e., liver fibrosis). Read More

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http://dx.doi.org/10.1016/j.abb.2020.108445DOI Listing

Estrogen receptors participate in silibinin-caused nuclear translocation of apoptosis-inducing factor in human breast cancer MCF-7 cells.

Arch Biochem Biophys 2020 Jun 7;689:108458. Epub 2020 Jun 7.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. Electronic address:

Our previous studies showed that silibinin promoted activation of caspases to induce apoptosis in human breast cancer MCF-7 cells by down-regulating the protein expression level of estrogen receptor (ER) α and up-regulating ERβ. Recently, it has been reported that silibinin-induced apoptosis also involved nuclear translocation of apoptosis-inducing factor (AIF). Here we report that silibinin induces nuclear translocation of AIF through the down-regulation of ERα and up-regulation of ERβ in a concentration dependent manner in MCF-7 cells. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108458DOI Listing

Dietary nitrate attenuated endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for NADPH oxidase.

Arch Biochem Biophys 2020 Jun 7;689:108453. Epub 2020 Jun 7.

Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Key Laboratory of Green Chemistry, Jiangxi Province and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, China. Electronic address:

Nitric oxide (NO) deficiency and NADPH oxidase plays key roles in endothelial dysfunction and atherosclerotic plaque formation. Recent evidence demonstrates that nitrate-nitrite-NO pathway in vivo exerts beneficial effects upon the cardiovascular system. We aimed to investigate the effects of dietary nitrate on endothelial function and atherosclerosis in apolipoprotein E knockout (ApoE) mice fed a high-fat diet. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108453DOI Listing

Role of lycopene in smoke-promoted chronic obstructive pulmonary disease and lung carcinogenesis.

Arch Biochem Biophys 2020 Jun 3;689:108439. Epub 2020 Jun 3.

Nutrition and Cancer Biology Lab, Jean Mayer USDA-Human Nutrition Research Center on Aging (HNRCA) at Tufts University, Boston, MA, USA; Biochemical and Molecular Nutrition Program, Friedman School of Nutrition and Policy, Tufts University, Boston, MA, USA. Electronic address:

Chronic obstructive pulmonary disease (COPD) and lung cancer are a major cause of morbidity and mortality worldwide, with cigarette smoking being the single most important risk factor for both. Emerging evidence indicates alterations in reverse cholesterol transport-mediated removal of excess cholesterol from lung, and intracellular cholesterol overload to be involved in smoke-promoted COPD and lung cancer development. Since there are currently few effective treatments for COPD and lung cancer, it is important to identify food-derived, biologically active compounds, which can protect against COPD and lung cancer development. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108439DOI Listing

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria.

Arch Biochem Biophys 2020 Jun 2:108416. Epub 2020 Jun 2.

Plants for Human Health Institute, Dept. of Animal Science, NC Research Campus, NC State University, Kannapolis, 28081, NC, USA; Dept. of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121, Ferrara, Italy; Dept. of Food and Nutrition, Kyung Hee University, 02447, Seoul, South Korea. Electronic address:

Alkaptonuria (AKU) is a rare metabolic disease correlated with the deficiency of homogentisate 1,2-dioxygenase and leading to an accumulation of the metabolite homogentisic acid (HGA) which can be subjected to oxidation and polymerization reactions. These events are considered a trigger for the induction of oxidative stress in AKU but, despite the large description of an altered redox status, the underlying pathogenetic processes are still unstudied. In the present study, we investigated the molecular mechanisms responsible for the oxidative damage present in an osteoblast-based cellular model of AKU. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108416DOI Listing

Selenoprotein I is essential for murine embryogenesis.

Arch Biochem Biophys 2020 Jun 2;689:108444. Epub 2020 Jun 2.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. Electronic address:

Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of phosphatidylethanolamine. Since the role of SELENOI in murine embryogenesis has not been investigated, SELENOI mating pairs were used to generate global KO offspring. Of 323 weanling pups, no homozygous KO genotypes were found. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108444DOI Listing

Role of amino acids in regulation of ROS balance in cancer.

Arch Biochem Biophys 2020 Jun 1;689:108438. Epub 2020 Jun 1.

Centre de Recherche en Cancérologie de Marseille (CRCM), UMR 1068, Institut National de la Santé et de la Recherche Médicale, F-13009, Marseille, France; Institut Paoli-Calmettes (IPC), F-13009, Marseille, France; Unité Mixte de Recherche (UMR 7258), Centre National de la Recherche Scientifique (CNRS), F-13009, Marseille, France; Université Aix-Marseille UM105, F-13284, Marseille, France. Electronic address:

Cancer cells display increased oxidative stress from reactive oxygen species (ROS) and constantly have to counteract them below a tolerable threshold to avoid any toxicity due to overload of ROS. The involvement of ROS in cancer progression from precursor lesions to aggressive tumor and metastasis formation is still debated, but it is recognized that cancer cells succeed to use ROS for their own benefit in circumstances that are tumor cell-type specific. In this review, we focus on amino acids' metabolic pathways that tumor cells activate as antioxidants including cysteine, methionine metabolisms and their connection with the folate, transulfuration pathways and ferroptosis. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108438DOI Listing

HCN2 activation modulation: An electrophysiological and molecular study of the well-preserved LCI sequence in the pore channel.

Arch Biochem Biophys 2020 May 31;689:108436. Epub 2020 May 31.

Departamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, 76230, Santiago de Querétaro, Querétaro, Mexico. Electronic address:

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the superfamily of voltage-gated potassium (Kv) and cyclic nucleotide-gated (CNG) channels. HCN channels contain the glycine-tyrosine-glycine (GYG) sequence that forms part of the selectivity filter, a similar structure than some potassium channels; however, they permeate both sodium and potassium, giving rise to an inward current. Yet a second amino acid sequence, leucine-cysteine-isoleucine (LCI), next to GYG, is well-preserved in all HCNs but not in the selective potassium channels. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108436DOI Listing

Role of carbonic anhydrases in ferroptosis-resistance.

Arch Biochem Biophys 2020 May 30;689:108440. Epub 2020 May 30.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan; Sydney Medical School, The University of Sydney, NSW, Australia. Electronic address:

Iron is essential for all the lives on earth but may trigger a switch toward ferroptosis, a novel form of regulated necrosis. Carbonic anhydrases (CAs) are ubiquitous enzymes from microbes to humans. The primary function of CAs is to regulate cellular pH by hydrating carbon dioxide (CO) to protons (H) and bicarbonate ions (HCO). Read More

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http://dx.doi.org/10.1016/j.abb.2020.108440DOI Listing

Structural and functional characterization of sticholysin III: A newly discovered actinoporin within the venom of the sea anemone Stichodactyla helianthus.

Arch Biochem Biophys 2020 May 30;689:108435. Epub 2020 May 30.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Madrid, Spain. Electronic address:

Actinoporins are a family of pore-forming toxins produced by sea anemones as part of their venomous cocktail. These proteins remain soluble and stably folded in aqueous solution, but when interacting with sphingomyelin-containing lipid membranes, they become integral oligomeric membrane structures that form a pore permeable to cations, which leads to cell death by osmotic shock. Actinoporins appear as multigenic families within the genome of sea anemones: several genes encoding very similar actinoporins are detected within the same species. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108435DOI Listing

The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes.

Arch Biochem Biophys 2020 May 30;689:108443. Epub 2020 May 30.

Department of Chemistry, Institute of Biochemistry, BOKU - University of Natural Resources and Life Sciences, Muthgasse 18, A-1190, Vienna, Austria. Electronic address:

Human peroxidasin 1 (PXDN) is a homotrimeric multidomain heme peroxidase and essential for tissue development and architecture. It has a biosynthetic function and catalyses the hypobromous acid-mediated formation of specific covalent sulfilimine (SN) bonds, which cross-link type IV collagen chains in basement membranes. Currently, it is unknown whether and which domain(s) [i. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108443DOI Listing

Biosynthesis of desferrioxamine siderophores initiated by decarboxylases: A functional investigation of two lysine/ornithine-decarboxylases from Gordonia rubripertincta CWB2 and Pimelobacter simplex 3E.

Arch Biochem Biophys 2020 May 30;689:108429. Epub 2020 May 30.

Environmental Microbiology, Institute of Biosciences, TU Bergakademie Freiberg, Leipziger Str. 29, 09599, Freiberg, Germany; Microbial Biotechnology, Ruhr-Universität Bochum, Universitätsstr. 150, 44780, Bochum, Germany. Electronic address:

Lysine is a precursor for desferrioxamine siderophore biosynthesis. The pathway is often initiated by lysine decarboxylases. However, little is known about those enzymes from Actinobacteria which represents a diverse class of desferrioxamine producers. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108429DOI Listing

Knockdown of circular RNA circ-FARSA restricts colorectal cancer cell growth through regulation of miR-330-5p/LASP1 axis.

Arch Biochem Biophys 2020 May 29;689:108434. Epub 2020 May 29.

Oncology Department, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan province, China. Electronic address:

Background: Circular RNA (circRNA) has been proposed to be involved in carcinogenesis. Here, we explored the functional significance and regulatory role of circ-FARSA in colorectal cancer (CRC).

Methods: Gene expression was determined using quantitative reverse transcriptase polymerase chain reaction and Western blot. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108434DOI Listing

Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition PIM-1 kinase activity.

Arch Biochem Biophys 2020 May 27:108413. Epub 2020 May 27.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Cancer Research Institute, Seoul National University, Seoul, 03080, South Korea. Electronic address:

The proviral integration site for Moloney murine leukemia virus (PIM) family of serine/threonine-specific kinases consist of three isoforms, that regulate proliferation, apoptosis, metabolism, invasion and metastasis of cancer cells. Among these, abnormally elevated kinase activity of PIM-1 contributes to the progression of gastric cancer and responsible for poor prognosis and low survival rate in gastric cancer patients. In the present study, we found that resveratrol, one of the representative chemopreventive and anticarcinogenic phytochemical, directly binds to PIM-1 and thereby inhibits its catalytic activity in human gastric cancer SNU-601 gastric cancer cells. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108413DOI Listing

Severity and duration of hypoxic stress differentially regulates HIF-1α-mediated cardiomyocyte apoptotic signaling milieu during myocardial infarction.

Arch Biochem Biophys 2020 May 27:108430. Epub 2020 May 27.

Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. Electronic address:

Background: The severity and duration of hypoxia is known to determine apoptotic fate in heart, however, its implication during myocardial infarction (MI) remains unaddressed. Therefore the aim of the study was to determine apoptotic regulation in cardiomyocytes under varied hypoxic intensity and duration and to unravel the role of HIF-1α in such modulation.

Methods: Treatment of cardiomyocytes to varied hypoxic intensity and duration was carried out in vitro, which was mimicked in vivo by dose-dependent Isoproterenol hydrochloride treatment for varied time-points. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108430DOI Listing
May 2020
3.017 Impact Factor

Necroptosis in renal ischemia/reperfusion injury: A major mode of cell death?

Arch Biochem Biophys 2020 May 26;689:108433. Epub 2020 May 26.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Ischemic acute kidney injury (AKI) is a frequent complication resulting from a myriad of conditions that decrease effective arterial blood volume to the kidneys including myocardial ischemia, sepsis, and hypovolemia. Following acute ischemic insult, restoration of renal blood flow inevitably leads to the aggravation of renal injury due to a widely researched condition known as ischemia/reperfusion (I/R) injury. For decades, apoptosis and necrosis have been proposed as being the two cell death pathways responsible for the pathogenesis of renal ischemic AKI. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108433DOI Listing

Black soybean improves the vascular function through an increase in nitric oxide and a decrease in oxidative stress in healthy women.

Arch Biochem Biophys 2020 Jul 26;688:108408. Epub 2020 May 26.

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.

Vascular dysfunction and injurious stimuli such as oxidative stress is closely related to the risk of cardiovascular diseases (CVD). Dietary polyphenols is reported to exert the beneficial effects on reducing the risk of CVD. Black soybean is rich in polyphenols, including isoflavones, anthocyanidins and flavan-3-ols, and its prevention effects on CVD risk were reported in the animal experiments. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108408DOI Listing

Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism.

Arch Biochem Biophys 2020 Jul 25;688:108414. Epub 2020 May 25.

Center for Low-temperature Plasma Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya, 484-8601, Japan.

Ringer's lactate solution irradiated by non-thermal plasma, comprised of radicals, electrons, and ions, is defined as plasma-activated lactate (PAL). PAL exhibited antitumor effects in glioblastoma U251SP cells, which we termed PAL-specific regulated cell death. In contrast to the oxidative stress condition typical of cells incubated in plasma-activated medium (PAM), U251SP cells treated with Ringer's lactate solution or PAL exhibited changes in intracellular metabolites that were reductive in the redox state, as measured by the ratio of oxidative/reductive glutathione concentrations. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108414DOI Listing

Aronia berry inhibits disruption of Caco-2 intestinal barrier function.

Arch Biochem Biophys 2020 Jul 25;688:108409. Epub 2020 May 25.

University of Wisconsin-Madison, Department of Food Science, 1605 Linden Dr., Madison, WI, 53711, USA. Electronic address:

The objective of this work was to determine how aronia berry polyphenols and its microbial catabolites improve intestinal barrier function. Caco-2 cells were cultured on transwell plates and allowed differentiate to form a model intestinal barrier, having baseline transepithelial electrical resistance (TEER) ≥ 300 Ω cm. Barrier function of differentiated Caco-2 cells was compromised by the addition of an inflammatory cocktail (IC: TNF-α, IL-1β, and IFN-γ to the basolateral media and lipopolysaccharide to the apical media). Read More

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http://dx.doi.org/10.1016/j.abb.2020.108409DOI Listing

Lipids and phenylketonuria: Current evidences pointed the need for lipidomics studies.

Arch Biochem Biophys 2020 Jul 24;688:108431. Epub 2020 May 24.

Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal. Electronic address:

Phenylketonuria (PKU) is the most prevalent inborn error of amino acid metabolism. The disease is due to the deficiency of phenylalanine (Phe) hydroxylase activity, which causes the accumulation of Phe. Early diagnosis through neonatal screening is essential for early treatment implementation, avoiding cognitive impairment and other irreversible sequelae. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108431DOI Listing
July 2020
3.017 Impact Factor

Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia.

Arch Biochem Biophys 2020 May 23;689:108411. Epub 2020 May 23.

Department of Neurology, Liaocheng People's Hospital of Shandong First Medical University, Liaocheng City, Shandong Province, 252000, China. Electronic address:

The process of ischemia/reperfusion (IR) in ischemic stroke often leads to significant cell death and permanent neuronal damage. Safe and effective treatments are urgently needed to mitigate the damage caused by IR injury. The naturally occurring pleiotropic peptide phoenixin 14 (PNX-14) has recently come to light as a potential treatment for IR injury. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108411DOI Listing
May 2020
3.017 Impact Factor

The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury.

Arch Biochem Biophys 2020 Jul 21;688:108410. Epub 2020 May 21.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA. Electronic address:

Kidneys from deceased donors used for transplantation are placed in cold storage (CS) solution during the search for a matched recipient. However, CS induces mitochondrial and cellular injury, which exacerbates renal graft dysfunction, highlighting the need for therapeutic interventions. Using an in vitro model of renal CS, we recently reported that pharmacological activation of the mitochondrial BK channel (mitoBK) during CS protected against CS-induced mitochondrial injury and cell death. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322695PMC
July 2020
3.017 Impact Factor

Curcumin suppress glioblastoma cell proliferation by p-AKT/mTOR pathway and increased the PTEN expression.

Arch Biochem Biophys 2020 May 20:108412. Epub 2020 May 20.

School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, 437100, PR China; The Central Hospital of Xianning, Hubei University of Science and Technology, Xianning, 437100, PR China. Electronic address:

Background: Glioblastoma (GB) is the most common neoplasm in the brain. Curcumin, as a known polyphenolic compound extracted from turmeric, is a chemotherapeutic used in some cancer treatments in china. However, the effects of curcumin on the survivability of GB cells remain to be elucidated. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108412DOI Listing

MicroRNA-27 attenuates pressure overload-Induced cardiac hypertrophy and dysfunction by targeting galectin-3.

Arch Biochem Biophys 2020 May 18;689:108405. Epub 2020 May 18.

Department of Intensive Care Unit, Hangzhou Hospital of Traditional Chinese Medicine (Dingqiao District), Guangxing Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Electronic address:

Cardiac hypertrophy is an adaptive response to hemodynamic stress to compensate for cardiac dysfunction. MicroRNAs can regulate cardiac function and play a vital role in the regulation of cardiac hypertrophy. In the current study, in vivo and vitro hypertrophy models are established to explore the role of miR-27b and to elucidate the underlying mechanism in cardiac hypertrophy. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108405DOI Listing

ALA protects against ERS-mediated apoptosis in a cochlear cell model with low citrate synthase expression.

Arch Biochem Biophys 2020 Jul 11;688:108402. Epub 2020 May 11.

Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, Shandong, PR China; Department of Biochemistry and Molecular Biology, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, Shandong, PR China. Electronic address:

A/J mouse is a model of age-related hearing loss (AHL). Mutation in the citrate synthase (Cs) gene of the mouse plays an important role in the hearing loss and degeneration of cochlear cells. To investigate the pathogenesis of cochlear cell damage in A/J mice resulted from Cs mutation, we downregulated the expression level of CS in HEI-OC1, a cell line of mouse cochlea, by shRNA. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108402DOI Listing

Disrupted potassium ion homeostasis in ciliary muscle in negative lens-induced myopia in Guinea pigs.

Arch Biochem Biophys 2020 Jul 11;688:108403. Epub 2020 May 11.

Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Disease in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China. Electronic address:

Myopia is a main cause of preventable or treatable visual impairment, it has become a major public health issue due to its increasingly high prevalence worldwide. Currently, it is confirmed that the development of myopia is associated with the disorders of accommodation. As a dominant factor for accommodation, ciliary muscle contraction/relaxation can regulate the physiological state of the lens and play a crucial role in the development of myopia. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108403DOI Listing

MicroRNA-621 inhibits the growth of gastric cancer cells by targeting SYF2.

Arch Biochem Biophys 2020 Jul 14;688:108406. Epub 2020 May 14.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, Jilin Province, 130033, China. Electronic address:

Increasing evidence indicates that aberrantly expressed microRNAs play a role in tumorigenesis and progression of gastric cancer. Recently, a novel cancer-related microRNA, miR-621, was found to be involved in cancer pathogenesis. However, the precise molecular mechanisms underlying the oncogenic activity of miR-621 remain unclear and require further investigation. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108406DOI Listing

IL-10 regulates the malignancy of hemangioma-derived endothelial cells via regulation of PCNA.

Arch Biochem Biophys 2020 Jul 13;688:108404. Epub 2020 May 13.

Department of Cardiovascula Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong Province, PR China. Electronic address:

Hemangioma (HA) is the most common benign tumor and formed by the proliferating endothelial cells of blood vessels. Interleukins (ILs) have been reported to be critical for HA progression. Our present study found that the expression of IL-10 was decreased in HA cells and tissues as compared to their corresponding controls. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108404DOI Listing

Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer.

Arch Biochem Biophys 2020 Jul 12;688:108407. Epub 2020 May 12.

Division of Biotechnology, DGIST, Daegu, Republic of Korea; Core Protein Resources Center, DGIST, Daegu, Republic of Korea. Electronic address:

Prostate cancer has the highest incidence among men in advanced countries, as well as a high mortality rate. Despite the efforts of numerous researchers to identify a gene-based therapeutic target as an effective treatment of prostate cancer, there is still a need for further research. The cathepsin gene family is known to have a close correlation with various cancer types and is highly expressed across these cancer types. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108407DOI Listing
July 2020
3.017 Impact Factor

AK002210 promotes the proliferation, migration and invasion of trophoblast cell through regulating miR-590/NAIP signal axis.

Arch Biochem Biophys 2020 Jul 6;688:108366. Epub 2020 May 6.

Department of Obstetrics and Gynecology, Shenzhen Hospital of Southern Medical University, China. Electronic address:

Preeclampsia (PE) is a pregnancy-related syndrome and has become the leading cause of maternal and neonatal morbidity and mortality. LncRNA has been elucidated to play critical roles in the phenotype of trophoblast cells. However, the effect of AK002210 has not been reported. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108366DOI Listing