1,029 results match your criteria Archives Of Physiology And Biochemistry [Journal]


The impact of concomitant administration of vanadium and insulin on endothelial dysfunction markers (PAI-1 and ET-1) in type 1 diabetic rats.

Arch Physiol Biochem 2019 Feb 21:1-8. Epub 2019 Feb 21.

a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

Endothelial dysfunction in type 1 diabetes mellitus (T1DM) is an important factor in the pathogenesis of micro- and macrovascular complications. The present study was to investigate the impact of combined vanadium and insulin for proper control and protection against endothelial dysfunction in T1DM rats. Sixty male Sprague-Dawley rats were randomly divided into six groups; control non-treated; control vanadium treated; T1DM; T1DM + insulin; T1DM + vanadium; T1DM + insulin + vanadium treated groups. Read More

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http://dx.doi.org/10.1080/13813455.2019.1573840DOI Listing
February 2019
1 Read

Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects.

Arch Physiol Biochem 2019 Feb 15:1-9. Epub 2019 Feb 15.

c Genetic Unit, Children Hospital , Mansoura University , Mansoura , Egypt.

Background: Several studies addressed the contribution of fat mass and obesity-associated (FTO) and leptin receptor (LEPR) polymorphisms for the susceptibility to obesity among different ethnic subjects. The main purpose of this work is to evaluate the association of these polymorph\isms with obesity among Egyptian subjects.

Subjects And Methods: This case-control study was carried out on 110 unrelated obese Egyptian subjects who were compared with 122 controls. Read More

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http://dx.doi.org/10.1080/13813455.2019.1573841DOI Listing
February 2019
1 Read

Analysis of angiotensin II-Induced rat urinary bladder contractions in the presence of angiotensin II receptors blockers.

Arch Physiol Biochem 2019 Feb 10:1-5. Epub 2019 Feb 10.

a Faculty of Medicine, Department of Physiology, Pathophysiology and Pharmacology , Trakia University , Stara Zagora , Bulgaria.

Objective: An application of a specific analysis on recordings obtained from urinary bladder (UB) preparations influenced with Angiotensin II (AngII) and AngII receptor (ATR) blockers was performed.

Methods: UB preparations were divided as follows: group 1 stimulated with AngII only; group 2:PD123319 (ATR type-2 blocker)+AngII; group 3:Losartan (ATR type-1 blocker)+AngII. The averaged time and force parameters of the contractions were processed by a spline interpolation and graphic images of the different patterns of the contractile activity were obtained. Read More

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http://dx.doi.org/10.1080/13813455.2018.1555669DOI Listing
February 2019
1 Read

Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats.

Arch Physiol Biochem 2019 Feb 10:1-10. Epub 2019 Feb 10.

a Centre for Biological Sciences, Department of Biochemistry , K.S. Rangasamy College of Arts and Science (Autonomous) , Tiruchengode , India.

In the current study, we evaluated the effects of Asiatic acid (AA) on lipid metabolic markers in HFD-induced obese Sprague-Dawley rat model. AA (20 mg/kg BW) was administered orally to HFD-fed rats for 42 days. Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats. Read More

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http://dx.doi.org/10.1080/13813455.2018.1555668DOI Listing
February 2019
5 Reads

Eight sessions of endurance training decrease fasting glucose and improve glucose tolerance in middle-aged overweight males.

Arch Physiol Biochem 2019 Jan 26:1-8. Epub 2019 Jan 26.

a Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.

Exercise improves metabolic regulation and reduces the risk of developing type 2 diabetes and other metabolic diseases. The recommendations for exercise are rather general and the health benefits of controlled training studies are important to make better recommendations. In the present study, we report that eight endurance training sessions over 3 weeks reduced fasting glucose, and improved glucose tolerance and plasma lipids in sedentary middle-aged males (44-64 years) with overweight or obesity (BMI: 27-38). Read More

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http://dx.doi.org/10.1080/13813455.2018.1563189DOI Listing
January 2019
1 Read

Effects of short-term fasting and pharmacological activation of AMPK on metabolism of rat adipocytes.

Arch Physiol Biochem 2019 Jan 19:1-6. Epub 2019 Jan 19.

a Department of Animal Physiology and Biochemistry , Poznan University of Life Sciences , Poznan , Poland.

AMP-activated protein kinase (AMPK) is a key intracellular energy sensor and regulates processes associated with energy metabolism. In the present study, effects of AICAR, a pharmacological activator of AMPK, on metabolism of adipocytes of non-fasted and 12-h fasted rats were compared. It was shown that in fat cells of control rats, epinephrine- and dibutyryl-cAMP-induced lipolysis was markedly reduced in the presence of AICAR. Read More

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http://dx.doi.org/10.1080/13813455.2018.1559862DOI Listing
January 2019
2 Reads

Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.

Arch Physiol Biochem 2019 Jan 19:1-4. Epub 2019 Jan 19.

c Department of Dermatology , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing , China.

Mesangial cells played a central role in the pathophysiology of diabetic nephropathy (DN). Our goal was to evaluate the molecular mechanism that regulates loss of BMP7 protein expression in DN. The mRNA and protein levels of BMP7 or UBE4A were detected using qRT-PCR and Western blot respectively. Read More

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http://dx.doi.org/10.1080/13813455.2018.1551905DOI Listing
January 2019
2 Reads

Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.

Arch Physiol Biochem 2019 Jan 20:1-10. Epub 2019 Jan 20.

a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , India.

Oral squamous cell carcinoma (OSCC) is widespread malignant neoplasm and refractory cancers in worldwide. Here, we studied the chemopreventive potential of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis (HBPCs). Oral tumours were developed in the buccal pouches of male golden Syrian hamsters by topical application of 0. Read More

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http://dx.doi.org/10.1080/13813455.2018.1555600DOI Listing
January 2019
2 Reads

Fructose-induced metabolic disturbances in rats and its impact on stomach endocrine cell number and smooth muscle contractility.

Arch Physiol Biochem 2019 Jan 11:1-9. Epub 2019 Jan 11.

a Department of General and Clinical Pathology , Trakia University , Stara Zagora , Bulgaria.

Context: Gastric ghrelin-positive endocrine cells (GHR + EC) were most dense in the oxyntic mucosa.

Objective: We evaluated ECs and contractile activity in rat stomach with metabolic disorders.

Materials And Methods: Male Wistar rats were divided into two groups: Control (n = 9) received tap water and Fructose (n = 9) drank 15% fructose solution for 12 weeks. Read More

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http://dx.doi.org/10.1080/13813455.2018.1555601DOI Listing
January 2019
3 Reads

Insulin-like and mimetic molecules from non-mammalian organisms: potential relevance for drug discovery.

Arch Physiol Biochem 2019 Jan 11:1-10. Epub 2019 Jan 11.

a Institute for Diabetes and Obesity , Helmholtz Diabetes Center (HDC), Helmholtz Center München , Oberschleissheim , Germany.

Insulin was first discovered in extracts of vertebrate pancreas during a focused search for a therapy for diabetes. Subsequent efforts to discover and isolate a similar active principle from yeast and plants driven by the hope to identify insulin-like/mimetic molecules with critical advantages in the pharmacokinetic profile and expenditure of production compared to authentic human insulin were not successful. As a consequence, it has generally been assumed that hormones evolved exclusively during course of the evolution of vertebrate endocrine organs, implying a rather recent origin. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1551906DOI Listing
January 2019
8 Reads

Cardioprotective effects of Galium verum L. extract against myocardial ischemia-reperfusion injury.

Arch Physiol Biochem 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Faculty of Medical Sciences, Department of Pharmacy , University of Kragujevac , Kragujevac , Serbia.

The aim of our study was to determine a chemical composition of methanol extract of Galium verum as well as to assess its effects on functional recovery and redox status of isolated rat heart after ischemia. Rats were divided into control and G. verum group, which included animals treated with 500 mg/kg of methanol extract of G. Read More

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http://dx.doi.org/10.1080/13813455.2018.1551904DOI Listing
January 2019
2 Reads

Standardized Olea europaea L. leaf extract exhibits protective activity in carbon tetrachloride-induced acute liver injury in rats: the insight into potential mechanisms.

Arch Physiol Biochem 2019 Jan 11:1-9. Epub 2019 Jan 11.

d Biomedical Research, R&D Institute , Galenika a.d. , Belgrade , Serbia.

The protective activity of dry olive leaf extract (DOLE) in carbon tetrachloride (CCl)-induced liver damage and possible mechanisms involved in this protection were investigated in rats. Acute CCl intoxication resulted in a massive hepatic necrosis, in increased serum transaminases, and in a perturbation of oxidative stress parameters in liver tissue [malondyaldehide, glutathione (GSH), catalase]. CCl did not affect the expression of caspase-3 and cytochrome c as markers of apoptosis; however, CCl increased the AMP-activated protein kinase (AMPK) activity and the expression of autophagy-related protein LC3II and decreased the expression of p62 protein. Read More

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http://dx.doi.org/10.1080/13813455.2018.1550095DOI Listing
January 2019
4 Reads

Higher levels of IL-18 in patients with prediabetes compared to obese normoglycaemic controls.

Arch Physiol Biochem 2019 Jan 11:1-4. Epub 2019 Jan 11.

c Laboratory of Tumor Immunology and Cell Therapy , Hyogo College of Medicine , Tokyo , Japan.

Background: Overweight and obesity are linked to low-grade chronic inflammation that can impair normal insulin function and induce insulin resistance. The aim of this study was to compare IL-18 levels between patients with prediabetes and obese normoglycaemic controls.

Patients And Methods: In this study, we included 131 patients with mean age 54. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1555667DOI Listing
January 2019
16 Reads

Relation between resistin, PPAR-γ, obesity and atherosclerosis in male albino rats.

Arch Physiol Biochem 2019 Jan 7:1-10. Epub 2019 Jan 7.

b Department of Basic Sciences , College of Medicine, Princess Nourah Bint Abdulrahman University , Riyadh , KSA.

Obesity and atherosclerosis are inflammatory states involving variable metabolic signals. The adipokine resistin is implicated in adipose tissue dysfunction and is modulated by PPARγ. In this study, resistin and PPARγ role is investigated in the development of CVS disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1550094DOI Listing
January 2019
2 Reads

Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.

Arch Physiol Biochem 2018 Dec 20:1-6. Epub 2018 Dec 20.

f Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes , Boston University Medical Center , Boston , MA, USA.

This study investigated the mRNA and protein levels of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells (PBMCs) from type 2 diabetes patients with retinopathy (diabetic retinopathy (DR) patients) (n = 86) and those without retinopathy (n = 103). The mRNA expression of SIRT1 and SIRT3 was found to be significantly higher in diabetic patients with retinopathy compared to those without retinopathy. Notably, protein levels of SIRT1, SIRT3, and SIRT4 were higher in patients with DR compared with controls after adjusting for diabetes duration and taking metformin (p = . Read More

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http://dx.doi.org/10.1080/13813455.2018.1543328DOI Listing
December 2018
2 Reads

The preventive effect of aqueous extract of Rosemary (Rosmarinus officinalis) leaves against the nephrotoxicity of carbon tetrachloride in mice.

Arch Physiol Biochem 2018 Nov 30:1-8. Epub 2018 Nov 30.

a Laboratory of Animal Ecophysiology Faculty of Sciences of Sfax , Sfax , Tunisia.

The present study aimed to evaluate the performance effect of aqueous extract of Rosmarinus officinalis (AERO) against the kidney toxicity induced by CCl in mice. The results showed that the renal damage induced by CCl was associated with a rise in oxidative stress monitored by a significant increase of TBARS and PCO levels (+89% and +136% respectively, p < .001) and a significant decrease of GSH level (-68%, p < . Read More

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http://dx.doi.org/10.1080/13813455.2018.1508236DOI Listing
November 2018
2 Reads

Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin.

Arch Physiol Biochem 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Physiology, School of Medical Sciences , Universiti Sains Malaysia , Kubang Kerian , Kelantan , Malaysia.

Context: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported.

Objective: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state.

Methods: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b. Read More

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http://dx.doi.org/10.1080/13813455.2018.1543329DOI Listing
December 2018
22 Reads

Cold stress modulates redox signalling in murine fresh bone marrow cells and promotes osteoclast transformation.

Arch Physiol Biochem 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Department of Physiology, Serampore College , Serampore , India.

Context: Alteration of redox signalling and RANK-L expression in FBMCs of mice exposed to different intensities of cold stress (15 °C, 8 °C and 4 °C) were studied.

Objective: To understand the effects of varying intensities of cold stress on murine FBMCs and its impact on osteoclastogenesis.

Materials And Methods: FBMCs were isolated from mice exposed to different intensities of cold stress and used for immunoblotting and biochemical assays. Read More

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http://dx.doi.org/10.1080/13813455.2018.1538249DOI Listing
November 2018
5 Reads

Tempol modulates the leukocyte response to inflammatory stimuli and attenuates endotoxin-induced sickness behaviour in mice.

Arch Physiol Biochem 2018 Nov 22:1-7. Epub 2018 Nov 22.

a Department of Biochemistry (DBq) , Institute of Biomedical Sciences, Federal University of Alfenas , Alfenas , Brazil.

Background And Aims: Lipopolysaccharide (LPS), an endotoxin, is a component of the outer membrane of Gram-negative bacteria that is able to activate the peripheral immune system, leading to changes in signalling pathways that act locally and systemically to achieve adaptive responses. Sickness behaviour is a motivational state in response to endotoxin exposure and includes depressed activity and a reduction of exploratory behaviour, potentially reorganising organism priorities to cope with infectious diseases. We hypothesised that 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) modulates the leukocyte response to endotoxins and decreases LPS-induced sickness behaviour in mice. Read More

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http://dx.doi.org/10.1080/13813455.2018.1538247DOI Listing
November 2018
1 Read

Exercise augments the modulatory effects of vitamin E on pre-diabetes-induced aortopathy: a potential role of adiponectin.

Arch Physiol Biochem 2018 Nov 22:1-7. Epub 2018 Nov 22.

a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

Background: We tested the hypothesis that vitamin E may protect against pre-diabetes-induced aortic injury (aortopathy), and exercise can augment the action of vitamin E.

Material And Methods: Rats were either fed with a high fat and fructose diet (HFD) (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. The three protective groups were treated with vitamin E (HFD + Vit E), swimming exercises (HFD + Ex), and vitamin E plus swimming exercises (HFD + VitE + Ex), respectively. Read More

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http://dx.doi.org/10.1080/13813455.2018.1538250DOI Listing
November 2018
24 Reads

Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules.

Arch Physiol Biochem 2018 Nov 21:1-6. Epub 2018 Nov 21.

a Department of Immunology, School of Medicine , Aja University of Medical Sciences , Tehran , IR Iran.

Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. Read More

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http://dx.doi.org/10.1080/13813455.2018.1538248DOI Listing
November 2018
7 Reads

Associations between ketone bodies and fasting plasma glucose in individuals with post-pancreatitis prediabetes.

Arch Physiol Biochem 2018 Nov 19:1-12. Epub 2018 Nov 19.

a School of Medicine , University of Auckland , Auckland , New Zealand.

Context: Levels of ketone bodies are altered in both acute pancreatitis and type 1 and type 2 diabetes. However, the role of ketone bodies in the pathogenesis of abnormal glucose metabolism after pancreatitis is largely unknown.

Objective: To investigate the associations between ketone bodies and glucose homeostasis in individuals with post-pancreatitis prediabetes (PPP) versus normoglycaemia after pancreatitis (NAP). Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1534242DOI Listing
November 2018
17 Reads

Physiological role of adiponectin in different tissues: a review.

Arch Physiol Biochem 2018 Nov 18:1-7. Epub 2018 Nov 18.

c Cellular and Molecular Research Center , Birjand University of Medical Sciences , Birjand , Iran.

Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1493606DOI Listing
November 2018
15 Reads

Insulin resistance and oxidative marker in women with PCOS.

Arch Physiol Biochem 2018 Nov 17:1-4. Epub 2018 Nov 17.

b Department of Research , Saveetha University , Thandalam, India.

Polycystic Ovary Syndrome is a multifactorial reproductive problem and a leading cause of female infertility worldwide. Evidences have shown that Oxidative Stress and decreased antioxidant status are often linked with PCOS. Insulin Resistance in PCOS patients ranges from 50% to 70% and may encourage OS by production of reactive oxygen species. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1499120DOI Listing
November 2018
22 Reads

Pretreatment of simvastatin on liver trace element levels during endotoxemia.

Arch Physiol Biochem 2018 Nov 17:1-5. Epub 2018 Nov 17.

f Department of Physiology, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey.

There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels was evaluated in liver during endotoxemia. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1508234DOI Listing
November 2018
18 Reads

Effect of amylin on memory and central insulin resistance in a rat model of Alzheimer's disease.

Arch Physiol Biochem 2018 Nov 17:1-9. Epub 2018 Nov 17.

b Department of Medical Biochemistry, Faculty of Medicine , Alexandria University , Alexandria , Egypt.

Context: Alzheimer's disease is strongly associated with brain insulin signalling.

Objective: Investigating the effect of amylin as a novel treatment in streptozotocin (STZ) rat model of AD.

Materials And Methods: Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg). Read More

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http://dx.doi.org/10.1080/13813455.2018.1534244DOI Listing
November 2018
2 Reads

Neuregulin 1 treatment improves glucose tolerance in diabetic db/db mice, but not in healthy mice.

Arch Physiol Biochem 2018 Nov 17:1-6. Epub 2018 Nov 17.

a Clermont Auvergne University, EA 3533, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P) , Clermont-Ferrand , France.

Context: Neuregulin 1 (NRG1) and ErbB receptors are involved in glucose homeostasis. However, the effects of the neuregulin 1-ErbB pathway activation on glucose metabolism in liver are controversial.

Objective: Assess NRG1 and ErbB signalling in liver and the effects of 8-week treatment with NRG1 on glucose homeostasis in diabetic db/db mice and in control healthy mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1534243DOI Listing
November 2018
16 Reads

Membrane insertion and intercellular transfer of glycosylphosphatidylinositol-anchored proteins: potential therapeutic applications.

Arch Physiol Biochem 2018 Nov 16:1-18. Epub 2018 Nov 16.

a Helmholtz Diabetes Center (HDC) at the Helmholtz Center München, Institute for Diabetes and Obesity , Oberschleissheim , Germany.

Anchorage of a subset of cell surface proteins in eukaryotic cells is mediated by a glycosylphosphatidylinositol (GPI) moiety covalently attached to the carboxy-terminus of the protein moiety. Experimental evidence for the potential of GPI-anchored proteins (GPI-AP) of being released from cells into the extracellular environment has been accumulating, which involves either the loss or retention of the GPI anchor. Release of GPI-AP from donor cells may occur spontaneously or in response to endogenous or environmental signals. Read More

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http://dx.doi.org/10.1080/13813455.2018.1498904DOI Listing
November 2018
12 Reads

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats.

Arch Physiol Biochem 2018 Nov 8:1-8. Epub 2018 Nov 8.

c King Fahd Medical Research Center, King Abdulaziz University , Jeddah , Saudi Arabia.

This study is undertaken to investigate the effects of naringenin on doxorubicin- (Dox) induced nephrotoxicity in Wistar rats. Dox 10 mg/kg body weight was administered intraperitoneally once and naringenin 50 and 100 mg/kg body weight was administered orally daily for 21 d. Dox-induced oxidative stress lead to steep elevation in blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH), and kidney injury molecule-1 (KIM-1), compared to control, treatment with naringenin preserved kidney functions. Read More

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http://dx.doi.org/10.1080/13813455.2018.1529799DOI Listing
November 2018
17 Reads

Smilax china leaf extracts suppress pro-inflammatory adhesion response in human umbilical vein endothelial cells and proliferation of HeLa cells.

Arch Physiol Biochem 2018 Oct 30:1-5. Epub 2018 Oct 30.

b Department of Physiology, College of Korean Medicine , Dongguk University , Gyeongju , South Korea.

Objective: The objective of this study was to investigate the anti-inflammatory and anticancer effects of the leaves of Smilax china.

Methodology: The aqueous extract was examined for its anti-inflammatory effects on tumour necrosis factor (TNF)-α-induced inflammation in HUVECs whereas the aqueous (water), ethyl acetate (EA), butanol (B) and methylene chloride (MC) extracts were examined for their anticancer effect on HeLa cells.

Results: The aqueous extract suppressed the (TNF)-α-induced expression of ICAM-1, VCAM-1 and TNF-R1 and attenuated the expression of MCP-1, MMP-9, NF-kB and IFN-γ. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1520262DOI Listing
October 2018
5 Reads

Superoxide dismutase: a review and a modified protocol for activities measurements in rat livers.

Arch Physiol Biochem 2018 Oct 29:1-8. Epub 2018 Oct 29.

b Department of Physiological Sciences , State University of Maringá , Maringá , Brazil.

Superoxide dismutase (SOD) enzymes are considered the first line of Defence against reactive oxygen species. Among the intracellular isoforms of SOD, Cu,ZnSOD is widely distributed, and the MnSOD is localised in the mitochondria. The SOD activities have been measured indirectly by inhibiting oxidation reactions. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1520891DOI Listing
October 2018
16 Reads

High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats.

Arch Physiol Biochem 2018 Oct 15:1-8. Epub 2018 Oct 15.

a Department of Medical Laboratory Sciences, School of Allied Medicine , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.

Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1511599DOI Listing
October 2018
10 Reads

Hemostatic effect of acylated ghrelin in control and sleeve gastrectomy-induced rats: mechanisms of action.

Arch Physiol Biochem 2018 Oct 15:1-10. Epub 2018 Oct 15.

a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

This study investigated the effect of acylated ghrelin (AG) deficiency after sleeve gastrectomy (SG) or chronic administration in control and SG-indiuced rats on platelet function, coagulation, and fibrinolysis. Administration of AG (100 µg/kg, subcutaneously) to control or SG rats significantly inhibited platelets aggregation and lowered levels of Von-Willebrand factor (vWF), fibrinogen, and thromboxane B2. Concomitantly, it decreased circulatory levels and aortic expression levels of plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) and increased the aortic expression of the endothelial nitric oxidase (eNOS). Read More

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http://dx.doi.org/10.1080/13813455.2018.1489849DOI Listing
October 2018
2 Reads

Anti-inflammatory potential of Trifolium pratense L. leaf extract in LPS-stimulated RAW264.7 cells and in a rat model of carrageenan-induced inflammation.

Arch Physiol Biochem 2018 Oct 15:1-8. Epub 2018 Oct 15.

a Department of Oral Biochemistry, College of Dentistry , Chosun University , Gwangju , Republic of Korea.

This study evaluated the anti-inflammatory potential of a 40% prethanol extract of Trifolium pratense leaves (40% PeTP) using in vitro (RAW264.7 cells) and in vivo (carrageenan-induced inflammation model) experiments. Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E (PGE), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in RAW264. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1493607DOI Listing
October 2018
3 Reads

High-intensity interval training (HIIT) alleviated NAFLD feature via miR-122 induction in liver of high-fat high-fructose diet induced diabetic rats.

Arch Physiol Biochem 2018 Oct 13:1-8. Epub 2018 Oct 13.

a Department of Medical Laboratory Sciences, School of Allied Medicine , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Exercise intervention is strongly recommended to manage metabolic diseases. In this study, we investigate, whether HIIT and CET can induce hepatic miR-122 expression, NAFLD rats with diabetes.

Methods: 40 Wistar rats divided into 2 groups, non-diabetic (NDC) and diabetic . Read More

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http://dx.doi.org/10.1080/13813455.2018.1510968DOI Listing
October 2018
6 Reads

Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid.

Arch Physiol Biochem 2018 Oct 13:1-10. Epub 2018 Oct 13.

a HOPE Cardiometabolic Research Team, Department of Physiology , University of Ilorin , Ilorin , Nigeria.

Context: Estrogen-progestin combined oral contraceptive (COC) has been connected to mineralocorticoid receptor (MR) activation and adverse cardiometabolic events. We consequently hypothesised that insulin resistance (IR), hyperuricemia, and elevated circulating GSK-3 induced by COC is through activation of MR via mineralocorticoid and glucocorticoid pathways.

Methods: Female Wistar rats aged 12 weeks received (po) vehicle and COC (1. Read More

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http://dx.doi.org/10.1080/13813455.2018.1509220DOI Listing
October 2018
2 Reads

Serum visfatin and adiponectin - markers in women with polycystic ovarian syndrome.

Arch Physiol Biochem 2018 Oct 13:1-4. Epub 2018 Oct 13.

b Department of Research , Saveetha University , Chennai , Tamil Nadu , India.

Aim: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility. Adipose tissue releases various adipokines, including visfatin and adiponectin, which have influence on insulin resistance (IR).

Objective: To determine serum insulin levels, IR, serum visfatin and adiponectin levels in PCOS subjects. Read More

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http://dx.doi.org/10.1080/13813455.2018.1518987DOI Listing
October 2018
16 Reads

Arecoline plays dual role on adrenal function and glucose-glycogen homeostasis under thermal stress in mice.

Arch Physiol Biochem 2018 Oct 13:1-11. Epub 2018 Oct 13.

a Department of Zoology , University of Calcutta , Calcutta , India.

Arecoline has biomedical importance, but it has untoward side effects on endocrine functions. The aim is to investigate its role on adrenal activity under thermal stress by ultrastructural and hormonal parameters in mice. Cold (4 °C) or heat (37 °C) stress, or arecoline (10 mg/kg body wt), each for 7 days in cold or heat stress stimulated adrenocortical activity ultrastructurally with an elevation of corticosterone level. Read More

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http://dx.doi.org/10.1080/13813455.2018.1508238DOI Listing
October 2018
4 Reads

Exercise intervention attenuates neuropathic pain in diabetes via mechanisms of mammalian target of rapamycin (mTOR).

Arch Physiol Biochem 2018 Oct 13:1-8. Epub 2018 Oct 13.

b Department of Blood Transfusion , The First Hospital of Jilin University , Changchun , Jilin , China.

This study was to examine the role of exercise intervention in modulating neuropathic pain induced by diabetes. Diabetes was induced by streptozotocin (STZ, i.p. Read More

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http://dx.doi.org/10.1080/13813455.2018.1489851DOI Listing
October 2018
11 Reads

Pancreatic islet dysfunction in type 2 diabetes mellitus.

Arch Physiol Biochem 2018 Oct 6:1-7. Epub 2018 Oct 6.

a Diabetes Research Center, School of Medicine , Ningbo University , Ningbo , China.

Islet dysfunction is a hallmark of type 2 diabetes mellitus (T2DM). Compelling evidence suggests that accumulation of islet amyloid in the islets of Langerhans significantly contribute to β-cell dysfunction and diabetes. Emerging evidence implicates a role for cystic fibrosis transmembrane-conductance regulator in the regulation of insulin secretion from pancreatic islets. Read More

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http://dx.doi.org/10.1080/13813455.2018.1510967DOI Listing
October 2018
3 Reads

Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways.

Arch Physiol Biochem 2018 Oct 5:1-9. Epub 2018 Oct 5.

a Antioxidants, Redox Biology and Toxicology Research Group , Department of Medical Biochemistry, College of Health Sciences , Nile University of Nigeria , Abuja , Nigeria.

This study investigated the influence of betulinic acid on high-fructose diet-induced metabolic syndrome in rats. Oral administration of betulinic acid significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, betulinic acid restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Read More

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http://dx.doi.org/10.1080/13813455.2018.1498901DOI Listing
October 2018
26 Reads

Consumption of Spinacia Oleracea (spinach) and aerobic exercise controls obesity in rats by an inhibitory action on pancreatic lipase.

Arch Physiol Biochem 2018 Sep 29:1-8. Epub 2018 Sep 29.

b Department of Pharmacognosy, SVKM's NMIMS, School of Pharmacy & Technology Management , Mukesh Patel Technology Park , Shirpur , India.

Context: Spinaciaoleracea (spinach) is abundant in antioxidant phytoconstituents, termed as the natural antioxidant mixture (NAO).

Objective: This study evaluates the anti-hyperlipidemicand anti-obesity effects of an antioxidant-rich extract of Spinaciaoleracea (NAOE) and aerobic exercise (AE) in rats fed with high fat diet (HFD).

Methods: Rats received NAOE (200 and 400 mg/kg), the standard drug orlistat (10 mg/kg), AE and NAOEAE (NAOE 400 mg/kg + AE) daily with HFD for 21 d. Read More

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http://dx.doi.org/10.1080/13813455.2018.1502323DOI Listing
September 2018
32 Reads

Pathophysiological and immunohistochemical analysis of pancreas after renal ischemia/reperfusion injury: protective role of melatonin.

Arch Physiol Biochem 2018 09 29:1-12. Epub 2018 Sep 29.

b Anatomy Department, Faculty of Medicine , Ain Shams University , Cairo , Egypt.

Objectives: To assess the remote pancreatic injury following renal ischemia/reperfusion (I/R) and to evaluate the effect of pre-treatment with melatonin on pancreatic structure and functions.

Methods: 21 rats were divided equally into sham group, renal I/R group, and melatonin pre-treated renal I/R (Mel-I/R) group.

Results: Renal I/R significantly increased serum amylase, fasting glucose and decreased serum insulin in I/R versus sham group. Read More

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http://dx.doi.org/10.1080/13813455.2018.1517182DOI Listing
September 2018
3 Reads

Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats.

Arch Physiol Biochem 2018 Sep 29:1-6. Epub 2018 Sep 29.

a Laboratory of Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco , Juarez Autonomous University of Tabasco , Tabasco , México.

The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Read More

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http://dx.doi.org/10.1080/13813455.2018.1517181DOI Listing
September 2018
9 Reads

Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates.

Arch Physiol Biochem 2018 Sep 29:1-10. Epub 2018 Sep 29.

a School of Biomedical Engineering , Dalian University of Technology , Dalian , China.

Insulin resistance is caused by various environmental and genetic factors leading to a number of serious health issues. Due to its multifactorial origin, molecular characterization may provide better tools for its effective treatment. On molecular level, dysregulation of signaling pathway by insulin receptor substrates (IRSs) is one of the most common reasons of this disease. Read More

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http://dx.doi.org/10.1080/13813455.2018.1498903DOI Listing
September 2018
7 Reads

Long non-coding RNA MALAT1 and microRNA-499a expression profiles in diabetic ESRD patients undergoing dialysis: a preliminary cross-sectional analysis.

Arch Physiol Biochem 2018 Sep 29:1-11. Epub 2018 Sep 29.

g Department of Histology and Cell Biology (Genetics Unit) , Faculty of Medicine, Suez Canal University , Ismailia , Egypt.

Background: Circulating non-coding RNAs (ncRNAs) have been implicated in health and disease. This study aimed to evaluate the serum expression profile of microRNA-499a (miR-499a) and its selected bioinformatically predicted partner long-ncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) in diabetes-related end-stage renal disease (ESRD) patients and to correlate the expressions with the patients' clinicolaboratory data.

Subjects And Methods: Real-time quantitative polymerase chain reaction was applied in diabetics with and without ESRD (n = 90 for each). Read More

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http://dx.doi.org/10.1080/13813455.2018.1499119DOI Listing
September 2018
7 Reads

Can maternal treatment with metformin during gestation and lactation cause metabolic and cardiovascular disorders in rat offspring?

Arch Physiol Biochem 2018 Sep 29:1-6. Epub 2018 Sep 29.

a Department of Physiological Sciences, Biological Sciences Center , State University of Londrina , Londrina , Brazil.

Objective: The aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring.

Materials And Methods: Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL).

Results: At 75 days of life, male and female MET offspring presented similar blood pressure when compared with their CTR. Read More

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http://dx.doi.org/10.1080/13813455.2018.1517804DOI Listing
September 2018
23 Reads

Galangin controls streptozotocin-caused glucose homeostasis and reverses glycolytic and gluconeogenic enzyme changes in rats.

Arch Physiol Biochem 2018 Sep 29:1-6. Epub 2018 Sep 29.

b Department of Community Health Sciences, College of Applied Medical Sciences , King Saud University , Riyadh , Saudi Arabia.

Galangin is a natural compound with anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorating effect of streptozotocin (STZ)-induced glucose homeostasis has not yet been evaluated. Hence, this study was aimed at exploring the role of galangin in STZ-induced glucose homeostasis, glycolytic and gluconeogenic enzyme changes in rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1
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http://dx.doi.org/10.1080/13813455.2018.1498521DOI Listing
September 2018
4 Reads

Endothelium-dependent vasodilatory effect of Smilax china Linn. water extract via PI3K/Akt signaling.

Arch Physiol Biochem 2018 Sep 29:1-5. Epub 2018 Sep 29.

b Department of Physiology College of Korean Medicine , Dongguk University , Gyeongju , South Korea.

Objective: The objective of this study was to investigate the pharmacological effect of Smilax china Linn. water extract (SCLWE) on vascular relaxation and its underlying biochemical mechanisms.

Methodology: Isolated rat aortic rings were pre-constricted with phenylephrine (PE). Read More

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http://dx.doi.org/10.1080/13813455.2018.1508237DOI Listing
September 2018
3 Reads

Natural products for the management of the hepatitis C virus: a biochemical review.

Arch Physiol Biochem 2018 Sep 29:1-13. Epub 2018 Sep 29.

b Pharmacognosy Department College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.

Chronic hepatitis C virus (HCV) infection is a significant public health problem, with a worldwide prevalence of approximately 170 million. Current therapy for HCV infection includes the prolonged administration of a combination of ribavirin and PEGylated interferon-α, for over a decade. This regimen is expensive and often associated with a poor antiviral response and unwanted side effects. Read More

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http://dx.doi.org/10.1080/13813455.2018.1498902DOI Listing
September 2018
4 Reads