Search our Database of Scientific Publications and Authors

I’m looking for a

    930 results match your criteria Archives Of Physiology And Biochemistry [Journal]

    1 OF 19

    Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease.
    Arch Physiol Biochem 2018 Feb 20:1-8. Epub 2018 Feb 20.
    b Department of Anatomical Sciences, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.
    Context: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder.

    Objective: Effects of combined therapy with resveratrol, interval and continuous exercises on oxidative stress, inflammation, and apoptosis in the liver of rats with NAFLD.

    Methods: NAFLD rats were organised in patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV groups. Read More

    Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats.
    Arch Physiol Biochem 2018 Feb 20:1-6. Epub 2018 Feb 20.
    d Department of Physiology , Firat University , Elazig , Turkey.
    There are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the anxiety/depression-like behaviours in male rats. Anxiety/depression-related behaviours were evaluated by use of forced swimming test and open field test. Read More

    Survey of the effect of doxorubicin and flavonoid extract of white Morus alba leaf on apoptosis induction in a-172 GBM cell line.
    Arch Physiol Biochem 2018 Feb 20:1-6. Epub 2018 Feb 20.
    c Department of Medicinal Plants , Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences , Tehran , Iran.
    In this study, the effect of doxorubicin, flavonoid extract of white Morus alba leaf (MFE) and a combination of doxorubicin and flavonoid extract on Bax and Bcl2 levels and caspase 3 activity of cancer A-172 GBM cell line was investigated. Bax/Bcl2 levels of treated A-172 GBM cell line with flavonoid extract of white mulberry leaf were estimated by ELISA methods. Caspase 3 activity of treated A-172 GBM cells was determined by calorimetric assay. Read More

    Natural products for controlling hyperlipidemia: review.
    Arch Physiol Biochem 2018 Feb 19:1-8. Epub 2018 Feb 19.
    b Pharmacognosy Department, College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.
    Hyperlipidemia is an abnormality of lipid metabolism, characterized by an elevation of total cholesterol, triglyceride, and low density lipoprotein-cholesterol, and/or a decreasing of high density lipoprotein cholesterol in circulating levels. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia-associated lipid disorders are considered the cause of atherosclerotic cardiovascular disease. Read More

    The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial Kchannel.
    Arch Physiol Biochem 2018 Feb 18:1-8. Epub 2018 Feb 18.
    b Faculty of Arts and Science, Department of Biology , Abant İzzet Baysal University , Bolu , Turkey.
    Context: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial Kchannel in the possible anti-arrhythmic actions of the treatments.

    Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p. Read More

    Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.
    Arch Physiol Biochem 2018 Feb 15:1-11. Epub 2018 Feb 15.
    h Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    Context: Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear.

    Objective: To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway.

    Materials And Methods: Rats were divided into control, sham, sham + ghrelin, myocardial infarction (MI), and MI + ghrelin groups. Read More

    Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance.
    Arch Physiol Biochem 2018 Feb 13:1-6. Epub 2018 Feb 13.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis.

    Material And Methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11week until being sacrificed, on Week 15. Read More

    Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na/K-ATPase.
    Arch Physiol Biochem 2018 Feb 13:1-10. Epub 2018 Feb 13.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g), and T1DM + RES + insulin and treated for eight weeks. While individual administrations of both drugs significantly but partially restored renal function and cortex architectures, combination therapy of both RES and insulin produced the maximum improvements. Read More

    High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome.
    Arch Physiol Biochem 2018 Feb 12:1-7. Epub 2018 Feb 12.
    b Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas , Universidade Federal de Santa Maria , Santa Maria , Brazil.
    This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VOmax), and lipid profile were assessed before and after HIIT. Read More

    Cytoprotective and antioxidant effects of the red alga Alsidium corallinum against hydrogen peroxide-induced toxicity in rat cardiomyocytes.
    Arch Physiol Biochem 2018 Feb 12:1-9. Epub 2018 Feb 12.
    d ORPHY, Optimization of Physiological Regulation, EA4324, Faculty of Medicine and Health Sciences , University of Western Brittany , Brest , France.
    Context: Sepsis is the manifestation of the immune and inflammatory responses to infection that may ultimately result in multiorgan failure. Many substances are involved in myocardial dysfunction in sepsis, including hydrogen peroxide.

    Objective: This study evaluates the protective activity of the red alga Alsidium corallinum against hydrogen peroxide (HO)-induced toxicity in H9c2 cardiomyocytes. Read More

    Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation.
    Arch Physiol Biochem 2018 Feb 10:1-15. Epub 2018 Feb 10.
    c Department of Medical Biochemistry, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Read More

    The enhancement of serotonin-induced contraction of rat femoral artery is mediated by angiotensin II release from intact endothelium.
    Arch Physiol Biochem 2018 Feb 10:1-12. Epub 2018 Feb 10.
    a Department of Pharmacology, Clinical Pharmacology and Toxicology; Faculty of Medicine , University of Belgrade , Belgrade , Serbia.
    We have performed an in vitro study on isolated intact or denuded femoral artery (FA) of healthy, diabetic, and/or rats submitted to the FA occlusion. The aim was to determine the contribution of endothelium and endothelial dysfunction (ED) on serotonin-induced action in FA. Further, the contribution of angiotensin II and cyclooxygenase products of arachidonic acid was investigated. Read More

    Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats.
    Arch Physiol Biochem 2018 Feb 9:1-8. Epub 2018 Feb 9.
    c Medical Plants Research Center, Basic Health Sciences Institute , Shahrekord University of Medical Sciences , Shahrekord , Iran.
    Context: Toxicity with paraquat can lead to serious damages to the liver.

    Objective: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage.

    Material And Methods: Rats were divided into six groups. Read More

    New lower cutoff for serum high sensitive C-reactive protein in obese women indicates the risk of metabolic syndrome.
    Arch Physiol Biochem 2018 Feb 2:1-5. Epub 2018 Feb 2.
    c Department of Public Health , Poznan University of Medical Sciences , Poznań , Poland.
    Objective, materials and methods: The aim of this cross-sectional study with a consecutive enrolment was to analyse the role of high sensitive C-reactive protein (hs-CRP) measurement in similarly obese patients with and without the metabolic syndrome (MS).

    Results: In total, 589 obese patients were screened, of whom 138 aged 50-75 years were enrolled. The others were rejected due to strict criteria of enrolment, so that the group was highly homogenous in numerous clinical aspects. Read More

    The potassium channel blocker, dalfampridine diminishes ouabain-induced arrhythmia in isolated rat atria.
    Arch Physiol Biochem 2018 Feb 1:1-5. Epub 2018 Feb 1.
    e Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.
    The aim of the present experiment was to investigate the possible antiarrhythmic effects of dalfampridine in ouabain-induced arrhythmia in rats. Twenty-four male rats including the control and dalfampridine-incubated (100 µM to 10 mM) ouabain-stimulated (40 µM) groups were used. After induction of anesthesia, the atria were isolated and the time of onset of arrhythmia and asystole were recorded. Read More

    Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard.
    Arch Physiol Biochem 2018 Feb 1:1-11. Epub 2018 Feb 1.
    a Biology Department , Science College, King Khalid University , Abha , Saudi Arabia.
    This study investigated the hepatotoxic effect of long-term vincristine (VCR) administration in rats and to assess if an individual or combined therapy with Indian mustard and broccoli afforded protection. Signs of hepatotoxicity, including altered liver architecture and higher serum levels of ALT and AST, were seen in VCR-treated rats. Concomitantly, the impaired antioxidant potential and higher mRNA levels of IL-12 and IL-4, which are markers of apoptosis, were seen in rat livers. Read More

    The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats.
    Arch Physiol Biochem 2018 Jan 24:1-7. Epub 2018 Jan 24.
    c Department of Chemistry, Faculty of Sciences , Ataturk University , Erzurum , Turkey.
    In our study, it was aimed to investigate the effects of cefazolin, cefuroxime, and cefoperazon injected to rats on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme activities in the heart, brain, eye, liver, and kidney tissues of rats. Liver AChE activity at the 1st and 3rd hours of cefuroxime groups was higher than the control group at the same time (p <.05). Read More

    High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-κB, and MAPK pathways in HepG2 cells.
    Arch Physiol Biochem 2018 Jan 24:1-7. Epub 2018 Jan 24.
    a Department of Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
    Objective: The aim of this study was to investigate the effects of high glucose (HG) on inflammation in HepG2 cells.

    Methods: The molecular mechanisms linking HG to inflammation was assessed in HepG2 cells exposed to HG (33 mM).

    Results: The results showed that HG significantly enhanced TNF-α, IL-6 and PAI-1 expression in HepG2 cells. Read More

    Association of carotid intima media thickness with atherogenic index of plasma, apo B/apo A-I ratio and paraoxonase activity in patients with non-alcoholic fatty liver disease.
    Arch Physiol Biochem 2018 Jan 23:1-6. Epub 2018 Jan 23.
    a Department of Clinical Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
    Background: NAFLD patients have higher risk of atherosclerosis cardiovascular disease (ASCVD). apo B/apoA-I ratio and atherogenic index of plasma (AIP) have been suggested as biomarker for ASCVD.

    Methods: apo A-I, apoB, aryl esterase (ARE) and paraoxonase (PON) activities and carotid intima media thickness (cIMT) were determined in 49 NAFLD patients and 33 controls. Read More

    Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin-angiotensin inhibition.
    Arch Physiol Biochem 2018 Jan 8:1-7. Epub 2018 Jan 8.
    c Department of Pathology (Nephropathology) , Kasr Alainy, Faculty of Medicine, Cairo University , Cairo , Egypt.
    Objective: We hypothesised that vitamin D has a beneficial renal protective effect from diabetic nephropathy (DN).

    Methods: Four rat groups were included: normal control (control), type 2 diabetes for eight weeks (DM), treated group with angiotensin receptor blocker losartan (DM + L), and vitamin D-treated group started from the onset of diabetes (DM + Vit D).

    Results: In the both treated groups, we found a significant (p < . Read More

    Physiological variations among blood parameters of domestic cats at high- and low-altitude regions of China.
    Arch Physiol Biochem 2018 Jan 8:1-3. Epub 2018 Jan 8.
    a Animal Science College , Tibet Agriculture & Animal Husbandry University , Linzhi , Tibet , People's Republic of China.
    This study aims to determine the comparative haematological parameters and to check possible physiological changes among blood parameters of domestic cats living at high- and low-altitude regions of China. For this purpose, blood samples were randomly collected from healthy semi-long-haired Tonkinese cats in Tibet (high altitude) and Zhejiang (low altitude) regions of China. The results of present study showed that RBCs, HGB, MCH and MCHC values of Tibetan Tonkinese cats were significantly (p < . Read More

    Ethnobotanical, phytochemical and therapeutic effects of Myrtus communis L. berries seeds on gastrointestinal tract diseases: a review.
    Arch Physiol Biochem 2018 Jan 5:1-7. Epub 2018 Jan 5.
    a Laboratoire de Physiologie Fonctionnelle et Valorisation des Bio-Ressources - Institut Supérieur de Biotechnologie de Béja , Université de Jendouba , Béja , Tunisia.
    Medicinal plants have always had an important place in the therapeutic arsenal of humanity and particularly in the treatment of gastrointestinal tract diseases. Myrtus communis L., known as common myrtle, is native to Southern Europe, North Africa, and Western Asia. Read More

    Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage.
    Arch Physiol Biochem 2018 Jan 5:1-10. Epub 2018 Jan 5.
    d Department of Biochemistry, Faculty of Veterinary Medicine , Bingol University , Bingol , Turkey.
    Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However, nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate protective effects of curcumin (CMN) against DXR-induced nephrotoxicity. Read More

    Arecoline ameliorates hyperthyroid condition in mice under cold stress.
    Arch Physiol Biochem 2017 Dec 26:1-6. Epub 2017 Dec 26.
    a Department of Zoology , University of Calcutta , Calcutta , India.
    Betel nut of Areca catechu is chewed by millions of people for increased capacity to work and stress reduction, but it contains arecoline that causes hypothyroidism. The aim is to investigate the role of arecoline on thyroid activity in cold stress in mice. Arecoline treatment (10 mg/kg body wt/day, for 7 d) caused a reduction in thyroid weight and ultrastructural degeneration of thyro-follicular cells with depletion of Tand Tlevels compared with the control mice. Read More

    Brain-derived neurotropic factor (BDNF) heterozygous mice are more susceptible to synaptic protein loss in cerebral cortex during high fat diet.
    Arch Physiol Biochem 2017 Dec 25:1-6. Epub 2017 Dec 25.
    b Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical University , Trabzon , Turkey.
    In this study we aimed to investigate whether reduced BDNF levels aggravate the susceptibility of the brain to hazardous effects of high fat diet. For this purpose, we fed BDNF heterozygous mice and wild type littermates with normal and high fat diet for 16 weeks. Concentrations of two synaptic proteins (SNAP-25 and PSD-95) and oxidative stress parameters (MDA, SOD, CAT) were evaluated in the cortex after diet period. Read More

    The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.
    Arch Physiol Biochem 2017 Dec 26:1-6. Epub 2017 Dec 26.
    a Suzhou Academy of Wumen Chinese Medicine , Suzhou Hospital of Traditional Chinese Medicine , Suzhou , P. R. China.
    Context: Sweet taste receptors (STRs) involve in regulating the release of glucose-stimulated glucagon-like peptide-1 (GLP-1). Our in vivo and in vitro studies found that 3-deoxyglucosone (3DG) inhibited glucose-stimulated GLP-1 secretion.

    Objective: This study investigated the role of STRs in 3DG-induced inhibition of high glucose-stimulated GLP-1 secretion. Read More

    Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats.
    Arch Physiol Biochem 2017 Dec 22:1-6. Epub 2017 Dec 22.
    c Department of Clinical Laboratory Sciences, College of Applied Medical Sciences , Taif University , Taif , KSA.
    The goal of this study was to investigate the effect of different phosphodiesterase inhibitors (PDEIs), on renal oxidant/antioxidant balance in diabetic rats. Our study was conducted on 125 rats, diabetes was induced in 100 rats by a single administration of streptozocin (STZ). Diabetic rats were divided into four equal groups. Read More

    Management of diabetes using herbal extracts: review.
    Arch Physiol Biochem 2017 Dec 21:1-7. Epub 2017 Dec 21.
    b Department of Pharmacognosy, College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.
    Diabetes is a group of metabolic diseases characterised by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage and dysfunction of many organs. Diabetes caused 1. Read More

    Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats.
    Arch Physiol Biochem 2017 Dec 20:1-8. Epub 2017 Dec 20.
    b Antioxidants, Redox Biology and Toxicology Research Group, Department of Medical Biochemistry , College of Health Sciences, Nile University of Nigeria , Abuja , Nigeria.
    This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, phenolic acids restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Read More

    Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
    Arch Physiol Biochem 2017 Dec 19:1-6. Epub 2017 Dec 19.
    a School of Medicine , Jordan University of Science and Technology , Irbid , Jordan.
    Peroxynitrite is a reactive nitrogen species produced in the intravascular compartment from superoxide anion and nitric oxide. Peroxynitrite destroys blood plasma proteins and membranes of red blood cells and of platelets. This explains why excessive production of peroxynitrite contributes to diseases and to ageing. Read More

    Pro-inflammatory cytokine-induced lipolysis after an episode of acute pancreatitis.
    Arch Physiol Biochem 2017 Dec 13:1-9. Epub 2017 Dec 13.
    a School of Medicine , University of Auckland , Auckland , New Zealand.
    Context: Pro-inflammatory cytokine-stimulated lipolysis is one of the mechanisms underlying the pathogenesis of type 2 diabetes. However, whether it plays a role in the pathogenesis of post-pancreatitis diabetes mellitus (PPDM) remains unknown.

    Objective: To investigate the associations between markers of lipid metabolism and pro-inflammatory cytokines in individuals after acute pancreatitis (AP) in general, and in individuals with abnormal glucose metabolism (AGM) following AP in particular. Read More

    Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling.
    Arch Physiol Biochem 2017 Dec 7:1-11. Epub 2017 Dec 7.
    c Department of Medical Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study aimed at studying the potential neuroprotective effect of Rutin hydrate (RH) alone or in conjugation with α-tocopherol against cadmium chloride (CdCl)-induced neurotoxicity and cognitive impairment in rats and to investigate the mechanisms of action. Rats intoxicated with CdClwere treated with the vehicle, RH, α-tocopherol or combined treatment were examined, and compared to control rats received vehicle or individual doses of either drug. Data confirmed that RH improves spatial memory function by increasing acetylcholine availability, boosting endogenous antioxidant potential, activating cell survival and inhibiting apoptotic pathways, an effect that is more effective when RH was conjugated with α-tocopherol. Read More

    Demographic and lifestyle factors that affect HbA1c awareness amongst type II diabetic patients in Trinidad.
    Arch Physiol Biochem 2017 Dec 6:1-4. Epub 2017 Dec 6.
    a Faculty of Medical Sciences, Department of Preclinical Sciences , The University of the West Indies , Mount Hope , Trinidad and Tobago.
    Objectives: To determine the awareness of HbA1c values and correlate this with educational levels, dietary intake and physical activity in type II diabetic population of Trinidad.

    Methods: Total of 222 type II diabetic subjects were assessed via questionnaire evaluating their demographics, type and duration of diabetes, type and frequency of glucose testing, dietary intake and physical activity. HbA1c data was coded as patients who were aware versus patients who were not aware. Read More

    Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats.
    Arch Physiol Biochem 2017 Dec 6:1-6. Epub 2017 Dec 6.
    b Department of Biochemistry , University of Allahabad , Allahabad , India.
    Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain tissues of alloxan-induced diabetic rats in vivo. Enhanced lipid peroxidation, protein oxidation and reduced antioxidative defence systems were measured in brain tissues of diabetic rats. Supplementation of CLE, once in a day for 35 days significantly (p < . Read More

    Effect of certain non-steroidal anti-inflammatory drugs on the paraoxonase 2 (PON2) in human monocytic cell line U937.
    Arch Physiol Biochem 2017 Dec 3:1-5. Epub 2017 Dec 3.
    b Department of Medical Pharmacology , Faculty of Medicine, Balıkesir University , Balikesir , Turkey.
    The paraoxonase gene family in humans consists of three members as PON1, PON2 and PON3. PON2 can be expressed in several tissues; however, it is not released from the cells in those tissues. PON2 is also expressed in macrophages. Read More

    The effect of oxidative stress on the progression of Hashimoto's thyroiditis.
    Arch Physiol Biochem 2017 Nov 29:1-6. Epub 2017 Nov 29.
    c Department of Endocrinology and Metabolism , Ankara Numune Training and Research Hospital , Ankara , Turkey.
    Objective: We aimed to investigate the effects of oxidative stress in the pathogenesis and progression of Hashimoto's thyroiditis (HT).

    Methods: Forty euthyroid and 40 subclinical hypothyroid patients older than 18 years and not yet had received treatment were enrolled in the study.

    Results: In the 9 months follow-up, 14 of the HT patients developed overt hypothyroidism. Read More

    Arterial stiffness, plasma atherogenic index and soluble cell adhesion molecules in healthy young adults with reduced physical activity.
    Arch Physiol Biochem 2017 Nov 28:1-4. Epub 2017 Nov 28.
    c First Department of Internal Diseases, Section of Cardiology, Medical Faculty , Medical University , Plovdiv , Bulgaria.
    Objective: To examine some anthropometric parameters, arterial stiffness, lipid profile, and soluble adhesion molecules in young adults with reduced physical activity.

    Material And Methods: The study is carried on 54 healthy young adults aged 20.97 ± 2. Read More

    Lack of effects of myo-inositol on metabolism of primary rat adipocytes.
    Arch Physiol Biochem 2017 Nov 27:1-7. Epub 2017 Nov 27.
    a Department of Animal Physiology and Biochemistry , Poznan University of Life Sciences , Poznan , Poland.
    Myo-inositol is a ubiquitous cyclitol, has an important regulatory role, and its intracellular depletion is associated with pathological changes. Effects of myo-inositol on adipose tissue are poorly elucidated. In this report, short-term influence of 20, 100, and 500 µM myo-inositol on metabolism of the isolated rat adipocytes was studied. Read More

    Hypolipidemic and cardioprotective effects of Ulva lactuca ethanolic extract in hypercholesterolemic mice.
    Arch Physiol Biochem 2017 Nov 24:1-13. Epub 2017 Nov 24.
    a Unit of Functional Genomics and Plant Physiology , Higher Institute of Biotechnology of Sfax, University of Sfax , Tunisia.
    Context: Hypercholesterolemia has significant cardiac consequences, since it is among the major risk factors of ischemic heart diseases.

    Objective: The aim was searching the cardioprotective effect of chemical constituents from the sea lettuce Ulva lactuca upon hypercholesterolemic regime in mice.

    Material And Methods: Mice were randomly divided into three groups: untreated group, hypercholesterolemic group, and mice receiving 1% cholesterol associated with U. Read More

    Reduced soluble Toll-like receptors 2 in type 2 diabetes.
    Arch Physiol Biochem 2017 Nov 21:1-4. Epub 2017 Nov 21.
    a Clinic of Endocrinology, Department of Internal Medicine, Faculty of Medicine , University Hospital Alexandrovska, Medical University - Sofia , Sofia , Bulgaria.
    Background: Soluble forms of Toll-like receptors (sTLR) 2 and 4 exert negative regulatory control on membrane-bound receptor activation. The study estimates the sTLR2 and sTLR4's serum levels in type 2 diabetes (T2D) and evaluates their relationship with metabolic and inflammatory parameters.

    Subjects And Methods: Sixty three patients with T2D and 25 controls were enrolled. Read More

    Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GCMS.
    Arch Physiol Biochem 2017 Nov 20:1-9. Epub 2017 Nov 20.
    a Laboratory of Pharmacology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia.
    The present study was aimed to evaluate the analgesic properties of Urtica dioica (UD) and to profile phytochemicals by gas chromatography-mass spectrometry (GC-MS). The ethanolic extracts were prepared by maceration method and extraction using rotary evaporator. The analgesic activity was analysed by hot plate method, formalin test, acetic acid-induced writhing test and the tail-flick test with different doses of the ethanolic extract. Read More

    Phenolic compounds analysis, antioxidant, and hepatoprotective effects of Periploca angustifolia extract on cadmium-induced oxidative damage in HepG2 cell line and rats.
    Arch Physiol Biochem 2017 Nov 20:1-14. Epub 2017 Nov 20.
    a Faculty of Sciences, Department of Life Sciences, Laboratory of Biodiversity and Aquatic Ecosystems, Ecology and Planktonology , University of Sfax , Sfax , Tunisia.
    A total of five components (Catechin, Caffeic acid, Ferulic acid, Rosmarinic acid, and Amentoflavone) were identified in Periploca angustifolia leaf methanolic extract. This extract did not cause any cytotoxic effect on HepG2 cell line within the range of concentrations tested (0-400 µg mL). Thus, pre-treatment with 100 µg mLof P. Read More

    Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults.
    Arch Physiol Biochem 2017 Nov 16:1-5. Epub 2017 Nov 16.
    a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group , School of Medicine, Universidad Antonio Nariño , Bogotá , Colombia.
    Obesity is becoming an epidemic in Latin American countries. Genetic analyses of endophenotypes for obesity, such as body mass index (BMI), are quite useful for research. In this study, we analysed two functional polymorphisms in the dopamine receptor 4 (DRD4) and dopamine transporter (SLC6A3) genes. Read More

    The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour.
    Arch Physiol Biochem 2017 Nov 7:1-7. Epub 2017 Nov 7.
    e Department of Medical Endocrinology (MEA) , Aarhus University Hospital , Aarhus , Denmark.
    Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA).

    Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats.

    Methods: Male Sprague-Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Read More

    Fibrotic and apoptotic markers alteration in ovariectomised rats: addition of swimming training preserves lung architecture.
    Arch Physiol Biochem 2017 Nov 7:1-6. Epub 2017 Nov 7.
    a Molecular Biology Department, Tuberculosis and Lung Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
    Context: The important role of exercise in pulmonary function during menopause is not well known. Oestrogen deficiency in ageing female mice is accompanied by increase in apoptotic markers such as caspase3 in the lung.

    Objective: The present study was designed to investigate whether swimming training will ameliorate fibrosis and apoptosis resolution in the ovariectomy-induced lung injury rats. Read More

    Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects.
    Arch Physiol Biochem 2017 Nov 7:1-6. Epub 2017 Nov 7.
    b Department of Clinical Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , I.R. Iran.
    Background: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects.

    Methods: Forty two healthy and 45 T2D subjects participated in this study. Read More

    Cardiopreventive effects of camel milk against carbon tetrachloride induced oxidative stress, biochemical and histological alterations in mice.
    Arch Physiol Biochem 2017 Nov 6:1-8. Epub 2017 Nov 6.
    c Research Unit of Toxicology, Environmental Microbiology and Health, Faculty of Science of Sfax , University of Sfax , Sfax , Tunisia.
    The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl) on the heart tissue of mice. Administration of a single dose of CClcaused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CClcaused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities. Read More

    A Helicobacter pylori-associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF-α or 1,4-dihydroxynonane mercapturic acid.
    Arch Physiol Biochem 2017 Nov 6:1-11. Epub 2017 Nov 6.
    e Department of Internal Medicine I, Institute of Cancer Research , Medical University of Vienna , Vienna , Austria.
    A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. Read More

    Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice.
    Arch Physiol Biochem 2017 Nov 2:1-8. Epub 2017 Nov 2.
    d Department of Biochemistry, Faculty of Medicine , Cairo University , Cairo , Egypt.
    Background: Parkinson's disease is a progressive neurodegenerative disorder. Aspartame (l-aspartyl-l-phenylalanine methyl ester), a low calorie sweetener used in foods and beverages.

    Objectives: This study investigated the effect of chronic aspartame intake on Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Read More

    Zinc and selenium modulate barium-induced oxidative stress, cellular injury and membrane-bound ATPase in the cerebellum of adult rats and their offspring during late pregnancy and early postnatal periods.
    Arch Physiol Biochem 2017 Oct 26:1-10. Epub 2017 Oct 26.
    a Laboratory of Animal Physiology, Sciences Faculty of Sfax , University of Sfax , Sfax , Tunisia.
    Context: Barium (Ba) may induce oxidative stress leading to tissues injury.

    Objective: Our study investigated the therapeutic efficiency of zinc (Zn) and selenium (Se) against neurotoxicity induced by Ba in adult rats and their progeny.

    Material And Methods: Pregnant rats are exposed either to Ba (67 ppm), Ba + Zn, Ba + S or to only Zn and Se. Read More

    1 OF 19