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    891 results match your criteria Archives Of Physiology And Biochemistry [Journal]

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    Reduced soluble Toll-like receptors 2 in type 2 diabetes.
    Arch Physiol Biochem 2017 Nov 21:1-4. Epub 2017 Nov 21.
    a Clinic of Endocrinology, Department of Internal Medicine, Faculty of Medicine , University Hospital Alexandrovska, Medical University - Sofia , Sofia , Bulgaria.
    Background: Soluble forms of Toll-like receptors (sTLR) 2 and 4 exert negative regulatory control on membrane-bound receptor activation. The study estimates the sTLR2 and sTLR4's serum levels in type 2 diabetes (T2D) and evaluates their relationship with metabolic and inflammatory parameters.

    Subjects And Methods: Sixty three patients with T2D and 25 controls were enrolled. Read More

    Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GCMS.
    Arch Physiol Biochem 2017 Nov 20:1-9. Epub 2017 Nov 20.
    a Laboratory of Pharmacology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia.
    The present study was aimed to evaluate the analgesic properties of Urtica dioica (UD) and to profile phytochemicals by gas chromatography-mass spectrometry (GC-MS). The ethanolic extracts were prepared by maceration method and extraction using rotary evaporator. The analgesic activity was analysed by hot plate method, formalin test, acetic acid-induced writhing test and the tail-flick test with different doses of the ethanolic extract. Read More

    Phenolic compounds analysis, antioxidant, and hepatoprotective effects of Periploca angustifolia extract on cadmium-induced oxidative damage in HepG2 cell line and rats.
    Arch Physiol Biochem 2017 Nov 20:1-14. Epub 2017 Nov 20.
    a Faculty of Sciences, Department of Life Sciences, Laboratory of Biodiversity and Aquatic Ecosystems, Ecology and Planktonology , University of Sfax , Sfax , Tunisia.
    A total of five components (Catechin, Caffeic acid, Ferulic acid, Rosmarinic acid, and Amentoflavone) were identified in Periploca angustifolia leaf methanolic extract. This extract did not cause any cytotoxic effect on HepG2 cell line within the range of concentrations tested (0-400 µg mL(-1)). Thus, pre-treatment with 100 µg mL(-1) of P. Read More

    Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults.
    Arch Physiol Biochem 2017 Nov 16:1-5. Epub 2017 Nov 16.
    a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group , School of Medicine, Universidad Antonio Nariño , Bogotá , Colombia.
    Obesity is becoming an epidemic in Latin American countries. Genetic analyses of endophenotypes for obesity, such as body mass index (BMI), are quite useful for research. In this study, we analysed two functional polymorphisms in the dopamine receptor 4 (DRD4) and dopamine transporter (SLC6A3) genes. Read More

    The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour.
    Arch Physiol Biochem 2017 Nov 7:1-7. Epub 2017 Nov 7.
    e Department of Medical Endocrinology (MEA) , Aarhus University Hospital , Aarhus , Denmark.
    Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA).

    Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats.

    Methods: Male Sprague-Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Read More

    Fibrotic and apoptotic markers alteration in ovariectomised rats: addition of swimming training preserves lung architecture.
    Arch Physiol Biochem 2017 Nov 7:1-6. Epub 2017 Nov 7.
    a Molecular Biology Department, Tuberculosis and Lung Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
    Context: The important role of exercise in pulmonary function during menopause is not well known. Oestrogen deficiency in ageing female mice is accompanied by increase in apoptotic markers such as caspase3 in the lung.

    Objective: The present study was designed to investigate whether swimming training will ameliorate fibrosis and apoptosis resolution in the ovariectomy-induced lung injury rats. Read More

    Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects.
    Arch Physiol Biochem 2017 Nov 7:1-6. Epub 2017 Nov 7.
    b Department of Clinical Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , I.R. Iran.
    Background: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects.

    Methods: Forty two healthy and 45 T2D subjects participated in this study. Read More

    Cardiopreventive effects of camel milk against carbon tetrachloride induced oxidative stress, biochemical and histological alterations in mice.
    Arch Physiol Biochem 2017 Nov 6:1-8. Epub 2017 Nov 6.
    c Research Unit of Toxicology, Environmental Microbiology and Health, Faculty of Science of Sfax , University of Sfax , Sfax , Tunisia.
    The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CCl4 caused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities. Read More

    A Helicobacter pylori-associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF2-α or 1,4-dihydroxynonane mercapturic acid.
    Arch Physiol Biochem 2017 Nov 6:1-11. Epub 2017 Nov 6.
    e Department of Internal Medicine I, Institute of Cancer Research , Medical University of Vienna , Vienna , Austria.
    A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. Read More

    Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice.
    Arch Physiol Biochem 2017 Nov 2:1-8. Epub 2017 Nov 2.
    d Department of Biochemistry, Faculty of Medicine , Cairo University , Cairo , Egypt.
    Background: Parkinson's disease is a progressive neurodegenerative disorder. Aspartame (l-aspartyl-l-phenylalanine methyl ester), a low calorie sweetener used in foods and beverages.

    Objectives: This study investigated the effect of chronic aspartame intake on Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Read More

    Zinc and selenium modulate barium-induced oxidative stress, cellular injury and membrane-bound ATPase in the cerebellum of adult rats and their offspring during late pregnancy and early postnatal periods.
    Arch Physiol Biochem 2017 Oct 26:1-10. Epub 2017 Oct 26.
    a Laboratory of Animal Physiology, Sciences Faculty of Sfax , University of Sfax , Sfax , Tunisia.
    Context: Barium (Ba) may induce oxidative stress leading to tissues injury.

    Objective: Our study investigated the therapeutic efficiency of zinc (Zn) and selenium (Se) against neurotoxicity induced by Ba in adult rats and their progeny.

    Material And Methods: Pregnant rats are exposed either to Ba (67 ppm), Ba + Zn, Ba + S or to only Zn and Se. Read More

    Understanding mitochondrial biogenesis through energy sensing pathways and its translation in cardio-metabolic health.
    Arch Physiol Biochem 2017 Oct 26:1-13. Epub 2017 Oct 26.
    a Department of Pharmacology , Bombay College of Pharmacy , Mumbai , India.
    Mitochondria play a pivotal role in physiological energy governance. Mitochondrial biogenesis comprises growth and division of pre-existing mitochondria, triggered by environmental stressors such as endurance exercise, caloric restriction, cold exposure and oxidative stress. For normal physiology, balance between energy intake, storage and expenditure is of utmost important for the coordinated regulation of energy homeostasis. Read More

    The effect of zinc and melatonin supplementation on immunity parameters in breast cancer induced by DMBA in rats.
    Arch Physiol Biochem 2017 Oct 23:1-6. Epub 2017 Oct 23.
    b Department of Pediatric Immunology, Medical Faculty , Selcuk University , Konya, Turkey.
    Objective: The aim of the study was to determine the effects of zinc and melatonin supplements on the immunity parameters of female rats with breast cancer induced by DMBA.

    Methods: Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), Group 3; DMBA + zinc, Group 4; DMBA + melatonin, Group 5; DMBA + zinc + melatonin. The rats' breast cancer was induced by DMBA 80 mg/kg. Read More

    A novel biomarker explaining the role of oxidative stress in exercise and l-tyrosine supplementation: thiol/disulphide homeostasis.
    Arch Physiol Biochem 2017 Oct 11:1-5. Epub 2017 Oct 11.
    a Faculty of Yasar Dogu Sports Sciences , Ondokuz Mayıs University , Samsun , Turkey.
    The present study aimed to evaluate the relationship between exercise and both l-tyrosine and oxidative stress using thiol/disulphide homeostasis via a novel biomarker in rats. Following the completion of the exercise and l-tyrosine protocol, serum total thiol, native thiol, and disulphide concentrations were determined using a novel automated measurement method. Compared with the control group, serum dynamic disulphide levels were significantly lower in the E group (116. Read More

    Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease.
    Arch Physiol Biochem 2017 Oct 11:1-6. Epub 2017 Oct 11.
    a Centre for Medical Biotechnology, Amity Institute of Biotechnology , Amity University Uttar Pradesh , Noida , India.
    Content: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways.

    Objective: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein-protein interaction (PPI) network. Read More

    High-fat diet reduces weight gain but increases other cardio-metabolic indices in offspring of normotensive and hypertensive rats.
    Arch Physiol Biochem 2017 Sep 27:1-8. Epub 2017 Sep 27.
    d Department of Physiology, College of Health Sciences , University of Ilorin , Ilorin , Kwara , Nigeria.
    This study investigated the effect of post-natal consumption of high-fat diet (HFD) on cardio-metabolic indices in male offspring of hypertensive female rats. There were neither significant differences in body weight gain either in pups from normotensive or hypertensive dams that received normal diet during the post-weaning periods (except at 7th and 9th weeks), nor in both pup groups that received HFD. However, both pup groups that received HFD had reduced body weight gain when compared to their counterparts that received normal diet. Read More

    In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney.
    Arch Physiol Biochem 2017 Sep 18:1-11. Epub 2017 Sep 18.
    a Animal Eco-Physiology Laboratory, Sciences Faculty of Sfax , Université de Sfax , Sfax , Tunisia.
    The present study investigated the in vitro and the in vivo antioxidant capacities of Allium sativum (garlic) extract against deltamethrin-induced oxidative damage in rat's brain and kidney. The in vitro result showed that highest extraction yield was achieved with methanol (20.08%). Read More

    Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3β/NRF-2 signalling pathway.
    Arch Physiol Biochem 2017 Sep 14:1-9. Epub 2017 Sep 14.
    a Radiation Biology Department, National Centre for Radiation Research and Technology , Atomic Energy Authority , Cairo , Egypt.
    This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide or γ-radiation-induced neurotoxicity. To induce brain damage, animals were received acrylamide (25 mg/kg b.wt. Read More

    Effects of co-exposure to imidacloprid and gibberellic acid on redox status, kidney variables and histopathology in adult rats.
    Arch Physiol Biochem 2017 Sep 6:1-10. Epub 2017 Sep 6.
    a Animal Physiology Laboratory, Research Unit of Toxicology and Environmental Health, Sfax Faculty of Sciences , University of Sfax , Sfax , Tunisia.
    Data on the individual nephrotoxic effects of imidacloprid (IMI) and gibberellic acid (GA3) are scarce. Moreover, there is a lack of information about their combined effects on the renal tissue. Our study investigated the effects of IMI and GA3 separately or together on rats kidney. Read More

    Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
    Arch Physiol Biochem 2017 Sep 3:1-10. Epub 2017 Sep 3.
    a Cardiovascular Research Laboratory, Department of Physiology , University of Ilorin, Ilorin, Nigeria.
    Context: Cigarette smoking is considered to be a major risk factor for the development of diabetes and cardiovascular disease. Oestrogen-progestin combined oral contraceptive (COC) use has been associated with adverse cardiometabolic events.

    Objective: We hypothesized that nicotine would ameliorate insulin resistance (IR) that is accompanied by decreased cardiac glycogen synthase kinase-3 (GSK-3) and plasminogen activator inhibitor-1 (PAI-1). Read More

    Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects.
    Arch Physiol Biochem 2017 Sep 1:1-12. Epub 2017 Sep 1.
    b Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
    We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated from musculus vastus lateralis from healthy males with varying degrees of maximal oxygen uptake. Trained and intermediary trained subjects showed higher carbohydrate oxidation in vivo. Fibre-type distribution in biopsies and myotubes did not differ between groups. Read More

    Antiplatelets and profibrinolytic activity of Citrullus colocynthis in control and high-fat diet-induced obese rats: mechanisms of action.
    Arch Physiol Biochem 2017 Aug 31:1-11. Epub 2017 Aug 31.
    a Department of Clinical Laboratory Sciences, College of Applied Medical Sciences , King Saud Bin Abdulaziz University for Health Sciences , Riyadh , Saudi Arabia.
    The current study aimed to investigate the effect of Citrullus colocynthis (C. colocynthis) hydro-alcoholic extract on blood haemostasis in control and high-fat diet (HFD) induced obese rats. In control rats, the extract significantly enhanced bleeding time and plasma levels of tPA and significantly decreased plasma levels PAI-1 and serum levels of thromboxane B2 leading to inhibition of platelets aggregation. Read More

    High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women.
    Arch Physiol Biochem 2017 Aug 31:1-7. Epub 2017 Aug 31.
    b Department of Internal Medicine , Trakya University Medical Faculty , Edirne , Turkey.
    The aim of this study was to investigate the plasma adipokine responses to high-intensity interval training (HIT) in overweight/obese women. Twelve women (age 21.7 ± 3. Read More

    Supplementation of all trans retinoic acid ameliorates ethanol-induced endoplasmic reticulum stress.
    Arch Physiol Biochem 2017 Aug 31:1-8. Epub 2017 Aug 31.
    a Department of Biochemistry , University of Kerala , Thiruvananthapuram , Kerala , India.
    Context: Molecular pathogenesis of chronic alcoholism is linked to increased endoplasmic reticulum stress. Ethanol is a competitive inhibitor of vitamin A metabolism and vitamin A supplementation aggravates existing liver problems. Hence, we probed into the impact of supplementation of all trans retinoic acid (ATRA), the active metabolite of vitamin A on ethanol-induced endoplasmic reticulcum stress. Read More

    Refeeding after caloric restriction reverses altered liver glucose release.
    Arch Physiol Biochem 2017 Aug 30:1-4. Epub 2017 Aug 30.
    a Department of Physiological Sciences , State University of Maringá , Maringá , Brazil.
    Context: Caloric restriction increases liver glucose release (LGR), but it is not known if this is a permanent condition.

    Objective: To investigate if refeeding after caloric restriction reverses the high LGR.

    Materials And Methods: Rats were organised in six-pups litters (GC); 12-pups litters with either 50% caloric restriction from 21 to 80 days of age (GR) or fed at will from 50 to 80 days of age (GRL). Read More

    Combined effect of retinoic acid and calcium on the in vitro differentiation of human adipose-derived stem cells to adipocytes.
    Arch Physiol Biochem 2017 Aug 29:1-10. Epub 2017 Aug 29.
    f Department of Immunology, School of Public Health , Tehran University of Medical sciences , Tehran , Iran.
    Context: It has been shown that adipogenesis can be modulated by factors such as all-trans retinoic acid (ATRA) and calcium.

    Objective: To determine, the combined effect of ATRA and calcium on the differentiation of human adipose-derived stem cells (hADSCs).

    Methods: Mesenchymal stem cells (MSCs) were differentiated into the adipocytes by 0. Read More

    Really does temperature reduction and norepinephrine have similar effects on the energy metabolism in rat brown adipose tissue?
    Arch Physiol Biochem 2017 Aug 26:1-7. Epub 2017 Aug 26.
    a Department of Medicine, School of Medicine , Universidad Complutense de Madrid , Madrid , Spain.
    Context: Heat generation by brown adipose tissue (BAT) in response to temperature reduction seems to be entirely related to sympathetic nervous stimulation.

    Objective: To analyse if temperature reduction and norepinephrine may differently affect the expression of proteins related to energy metabolism in BAT.

    Materials And Methods: Isolated rats BAT was incubated with/without norepinephrine (10(-6) mol/L, 24 h at 32 °C and 37 °C). Read More

    IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.
    Arch Physiol Biochem 2017 Aug 24:1-12. Epub 2017 Aug 24.
    a Clore Laboratory , University of Buckingham , Buckingham , UK.
    Regulation of the expression of GPCR fatty acid receptor genes has been examined in human adipocytes differentiated in culture. TNFα and IL-1β induced a marked reduction in GPR120 expression, mRNA level falling 17-fold at 24 h in adipocytes incubated with TNFα. In contrast, GPR84 mRNA was dramatically increased by these cytokines (>500-fold for IL-1β at 4 h); GPR41 expression was also stimulated. Read More

    Preclinical renal chemo-protective potential of Prunus amygdalus Batsch seed coat via alteration of multiple molecular pathways.
    Arch Physiol Biochem 2017 Aug 24:1-9. Epub 2017 Aug 24.
    a Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences , Sam Higginbottom University of Agriculture, Technology & Sciences , Allahabad , India.
    Prunus amygdalus Batsch (almond) is a classical nutritive traditional Indian medicine. Along with nutritive with anti-oxidant properties, it is, clinically, used in the treatment of various diseases with underlying anti-oxidant mechanism. This study is an effort to scrutinise the renal protective effect of P. Read More

    Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats.
    Arch Physiol Biochem 2017 Aug 17:1-8. Epub 2017 Aug 17.
    a Department of Chemistry, Faculty of Science and Art , Adiyaman University , Adiyaman , Turkey.
    In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. Read More

    Carbonic anhydrase I-II autoantibodies and oxidative status in long-term follow-up of patients with Crimean-Congo haemorrhagic fever.
    Arch Physiol Biochem 2017 Aug 10:1-6. Epub 2017 Aug 10.
    d Department of Infectious Diseases and Clinical Microbiology, Medical Faculty , Karadeniz Technical University , Trabzon , Turkey.
    Context: Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease.

    Objective: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I-II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF.

    Methods: Seventy CCHF patients and 39 healthy control volunteers were included in the study. Read More

    Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles.
    Arch Physiol Biochem 2017 Aug 9:1-8. Epub 2017 Aug 9.
    b Department of Chemistry, Faculty of Arts and Sciences , Gaziosmanpasa University , Tokat , Turkey.
    The new 1-(4-(3-(aryl)acryloyl)phenyl)-1H-pyrrole-2,5-diones (5a-g) were prepared from 4'-aminchalcones (3a-g) and screened for biological activities. All compounds (3a-g and 5a-g), except 3d and 3e displayed good cytotoxic activities with IC50 values in the range of 7.06-67. Read More

    Early detection of macular and peripapillary changes with spectralis optical coherence tomography in patients with prediabetes.
    Arch Physiol Biochem 2017 Aug 5:1-5. Epub 2017 Aug 5.
    a Department of Ophthalmology, School of Medicine , Dicle University , Diyarbakir , Turkey.
    Purpose: To compare the retina ganglion cell complex (GCC) layer and peripapillary nerve fibre layer thickness (pRNFL) in patients with prediabetes and healthy subjects analysed by spectral domain optical coherence tomography (SD-OCT).

    Methods: This cross-sectional and comparative study included prediabetic patients and healthy subjects. All participants underwent SD-OCT measurement of pRNFL thickness, and GCC thickness. Read More

    The interactions of cephalosporins on polyol pathway enzymes from sheep kidney.
    Arch Physiol Biochem 2017 Jul 31:1-10. Epub 2017 Jul 31.
    b Department of Biochemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey.
    Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.

    Objective: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. Read More

    Rapamycin mitigates erythrocyte membrane transport functions and oxidative stress during aging in rats.
    Arch Physiol Biochem 2017 Jul 31:1-9. Epub 2017 Jul 31.
    a Department of Biochemistry , University of Allahabad , Allahabad , India.
    Erythrocyte membrane is a suitable model to study various metabolic and physiological functions as it undergoes variety of biochemical changes during aging. An age-dependent modulatory effect of rapamycin on erythrocyte membrane functions is completely unknown. Therefore, the present study was undertaken to investigate the effect of rapamycin on age-dependent impaired activities of transporters/exchangers, altered levels of redox biomarkers, viz. Read More

    Cytoprotective effects of essential oil of Pinus halepensis L. against aspirin-induced toxicity in IEC-6 cells.
    Arch Physiol Biochem 2017 Dec 18;123(5):364-370. Epub 2017 Jul 18.
    a Laboratory ORPHY EA4324, UFR Sciences et Technique , Université de Bretagne Occidentale 6 Avenue Le gorgeu , Brest , France.
    Context: Essential oils from Pinus species have been reported to have various therapeutic properties.

    Objective: This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. Read More

    Protective effect of Teucrium polium on carbon tetrachloride induced genotoxicity and oxidative stress in rats.
    Arch Physiol Biochem 2017 Jul 16:1-9. Epub 2017 Jul 16.
    a Laboratory of Histology , Medicine Faculty of Sfax University , Sfax , Tunisia.
    This study aimed to investigate the protective effects of Teucrium polium (TP) on carbon tetrachloride (CCl4) induced spleen, erythrocyte's oxidative stress, and genotoxicity in rats. TP was found to contain large amounts of polyphenols (150 mg GAE/G of dry plant) and flavonoids (60 mg QE/g of quercetin dry plant). The CCl4 (0. Read More

    Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats.
    Arch Physiol Biochem 2017 Jul 14:1-8. Epub 2017 Jul 14.
    a Histology-Embryology Laboratory , Sfax Faculty of Medicine , Sfax , Tunisia.
    Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Read More

    Arecoline cannot alter testicular dysfunction and pineal activation caused by noise in wistar rat.
    Arch Physiol Biochem 2017 Jul 13:1-9. Epub 2017 Jul 13.
    a Department of Zoology , University of Calcutta , Kolkata , India.
    Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Read More

    A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats.
    Arch Physiol Biochem 2017 Dec 12;123(5):344-355. Epub 2017 Jul 12.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated the protective effect of subacute pre-adminsitration of either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) in rats and illustrates the possible mechanisms of action. While solely pre-administration of Se or Tau resulted in partial amelioration in all of the measured parameters in MI rats, concomitant administration of both drugs to MI rats significantly restored contractility function by increasing LVSP and decreasing LVEDP and significantly normalized serum levels of LDH, CK-MB and BNP and restored normal cardiac architecture. This concomitant treatment acted by increasing the activity of major antioxidant enzymes (SOD and GPx), decreasing the levels of inflammatory markers including TNF-α, IL-6 as well as levels of Bcl-2 and caspase-3 and downregulating mRNA levels of Bax and P53, markers of apoptosis. Read More

    Exendin-4, a glucagon-like peptide-1 receptor agonist downregulates hepatic receptor for advanced glycation end products in non-alcoholic steatohepatitis rat model.
    Arch Physiol Biochem 2017 Jul 11:1-8. Epub 2017 Jul 11.
    b Biochemistry Department, Faculty of Medicine , Benha University , Benha , Egypt.
    Context: Exendin-4, a glucagon-like peptide-1 receptor agonist has been shown to have curative effects on hepatic steatosis in murine models.

    Objective: The present study aimed to elucidate the effect of Exendin-4 on hepatic receptor for advanced glycation end products (RAGE) mRNA expression in non-alcoholic steatohepatitis (NASH) rat model induced by high-fat diet.

    Methods: NASH was induced by high-fat diet intake, and Exendin-4 was given in two different doses. Read More

    Potential protective effects of polysaccharide extracted from Ulva lactuca against male reprotoxicity induced by thiacloprid.
    Arch Physiol Biochem 2017 Dec 10;123(5):334-343. Epub 2017 Jul 10.
    a Unit of Functional Genomics and Plant Physiology , Higher Institute of Biotechnology of Sfax , Sfax , Tunisia.
    Context: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values.

    Objective: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system.

    Materials And Methods: Rats were exposed either to THC, THC + PS (100 mg/kg), or THC + PS (200 mg/kg). Read More

    The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population.
    Arch Physiol Biochem 2017 Dec 10;123(5):371-376. Epub 2017 Jul 10.
    a Department of Chemistry and Biochemistry, Medical Faculty , Trakia University , Stara Zagora , Bulgaria.
    Chronic inflammation and remodelling of the small airways are features related to chronic obstructive pulmonary disease (COPD). In the current study, we aimed to explore the possible role of MMP12 -82 A > G (rs2276109) promoter polymorphism in the development of COPD in a population from Bulgaria (167 patients with COPD and 119 control individuals). The genotype and allele distributions differed significantly between COPD patients and controls (p = . Read More

    Elevated resting heart rate is associated with the severity of coronary artery disease in non-treated patients who underwent coronary angiography: potential role of lipoprotein subfractions.
    Arch Physiol Biochem 2017 Dec 7;123(5):356-363. Epub 2017 Jul 7.
    a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China.
    Objective: To assess the association between resting heart rate (RHR) and lipoprotein subfractions to provide potential evidence for the relationship between RHR and severity of CAD.

    Methods: A total of 1119 consecutive non-treated subjects scheduled for coronary angiography were enrolled. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) separation were performed by Lipoprint System. Read More

    Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian patients.
    Arch Physiol Biochem 2017 Dec 18;123(5):330-333. Epub 2017 Jun 18.
    a Department of Biochemistry, Faculty of Pharmacy , Suez Canal University , Ismailia , Egypt.
    Context: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.

    Objective: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. Read More

    Modulatory effect of garcinol in streptozotocin-induced diabetic Wistar rats.
    Arch Physiol Biochem 2017 Dec 9;123(5):322-329. Epub 2017 Jun 9.
    b Department of studies in Zoology , University of Mysore , Mysuru , Karnataka (S) , India.
    The objective of the study was to evaluate the efficacy of garcinol as an antidiabetic candidate in streptozotocin-induced diabetic Wistar rats. Diabetic rats showed a significant increase in the biochemical parameters such as fasting blood glucose, glycated haemoglobin, urea, alanine aminotransferase and aspartate aminotransferase, malondialdehyde, total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index and a significant decrease in plasma insulin, HOMA-β-cell functioning index, glycogen, high-density lipoprotein cholesterol, body weight and antioxidant enzyme activities, viz. superoxide dismutase, catalase and reduced glutathione. Read More

    Synthesis and carbonic anhydrase inhibitory properties of new spiroindoline-substituted sulphonamide compounds.
    Arch Physiol Biochem 2017 Dec 31;123(5):306-312. Epub 2017 May 31.
    b Faculty of Arts and Sciences, Chemistry Department , Balikesir University , Balikesir , Turkey.
    New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of the 14 synthesised sulphonamides (6a-n) on esterase activities of these isoenzymes were studied in vitro. Read More

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