966 results match your criteria Archives Of Physiology And Biochemistry [Journal]


Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress.

Arch Physiol Biochem 2018 Jun 20:1-9. Epub 2018 Jun 20.

d Department of Chemistry, Faculty of Art and Science , Bingol University , Bingol , Turkey.

The present study was designed to explain the impact of amoxicillin, gentamicin, and cefazolin on the oxidative stress (OS) and reproductivity in the mouse testes. Our data showed that reduced glutathione (GSH) level, which is a marker for OS, strikingly reduced and hydrogen peroxide (HO) level, which acts as a signaling molecule in mammalian germ cells, strikingly increased with amoxicillin, gentamicin, and cefazolin treatment. The gene expression and enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), and glutathione-S-transferases (GST) were significantly affected in the presence of these antibiotics. Read More

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Role of some circulating MiRNAs on breast cancer diagnosis.

Arch Physiol Biochem 2018 Jun 20:1-9. Epub 2018 Jun 20.

c Division of Biochemistry, Faculty of Science , Damietta University , Damietta , Egypt.

Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids of cancer patients. Authors aimed to investigate the diagnostic role of miRNA-17-5p, miR-155 and miRNA-222 in serum samples from breast cancer patients (n = 80), benign breast patients (n = 40) and healthy individuals (n = 30) using quantitative real-time PCR technique. Median levels of investigated markers revealed significant increase in primary breast cancer followed by benign and control groups. Read More

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Glucocorticoid exposure causes disrupted glucoregulation, cardiac inflammation and elevated dipeptidyl peptidase-4 activity independent of glycogen synthase kinase-3 in female rats.

Arch Physiol Biochem 2018 Jun 18:1-9. Epub 2018 Jun 18.

a HOPE Cardiometabolic Research Team and Department of Physiology, College of Health Sciences , University of Ilorin , Ilorin , Nigeria.

Objective: We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory biomarkers, which are dipeptidyl peptidase-4 (DPP-4)- and glycogen synthase kinase-3 (GSK-3)-dependent.

Methods: Female Wistar rats received vehicle (control; n = 6) or GC (dexamethasone; n = 6; 0.2 mg/kg; p. Read More

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Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome.

Arch Physiol Biochem 2018 Jun 18:1-6. Epub 2018 Jun 18.

c Department of Biological and Biomedical Sciences , Aga Khan University , Karachi , Pakistan.

The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. Read More

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Phytoestrogens inhibit key-enzymes linked to obesity, type 2 diabetes and liver-kidney toxicity in high fructose-fat diet in mice.

Arch Physiol Biochem 2018 Jun 14:1-7. Epub 2018 Jun 14.

a Laboratory of Bioresources: Integrative Biology and Valorisation, Higher Institute of Biotechnology of Monastir , University of Monastir , Monastir , Tunisia.

Objective: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity.

Methods: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD).

Results: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity by 34%, decreased body weight by 20% and modulated lipid profile, showed a decrease in total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma by 59% and 42%, respectively, and increased the HDL-cholesterol (HDL-C) level by 31%. Read More

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Microwave extraction of Salvia officinalis essential oil and assessment of its GC-MS identification and protective effects versus vanadium-induced nephrotoxicity in Wistar rats models.

Arch Physiol Biochem 2018 Jun 8:1-10. Epub 2018 Jun 8.

a Laboratory of Animal Ecophysiology Faculty of Sciences of Sfax , Sfax University , Sfax , Tunisia.

In this study, we assess the impact of Salvia officinalis essential oil on renal toxicity induced by vanadium in rats. The animals were exposed to either ammonium metavanadate (5 mg/kg body weight) or the combination of vanadium and S. officinalis essential oil (15 mg EO/kg body weight) for 10 days. Read More

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Anti-diabetic effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on insulin production, blood glucose, and inflammatory markers in the experimental diabetes model.

Arch Physiol Biochem 2018 Jun 8:1-6. Epub 2018 Jun 8.

a Department of Immunology , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran.

This research aimed to evaluate the anti-diabetic effects of β-d-mannuronic acid (M2000) on blood glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats. Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p < .05). Read More

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June 2018
2 Reads

Endothelial dysfunction and intima media thickness are selectively related to the different carbohydrate disturbances across the glucose continuum.

Arch Physiol Biochem 2018 Jun 8:1-5. Epub 2018 Jun 8.

a Clinic of Endocrinology, University Hospital "Alexandrovska" Medical University-Sofia , Sofia , Bulgaria.

Aim: The aim of the present study was to investigate the prevalence of macrovascular complications across different carbohydrate disturbances.

Patients And Methods: In the study, we included 167 patients, divided them into three age and BMI matched groups - group 1 with obesity without carbohydrate disturbances (n = 66), group 2 with prediabetes (n = 68) and group 3 with newly diagnosed type 2 diabetes (n = 33). Endothelial function was evaluated using EndoPAT, intima media thickness (IMT) was measured on the common carotid artery and ankle-brachial index (ABI) was calculated. Read More

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June 2018
2 Reads

Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats.

Arch Physiol Biochem 2018 May 25:1-8. Epub 2018 May 25.

c Department of Pathology Faculty of Veterinary Medicine , Mustafa Kemal University , Hatay , Turkey.

In this study, we have investigated the effects of different doses of thymol (T) and carvacrol (C) on sperm quality oxidative stress and antioxidant system. For this purpose, 49 rats were divided into seven groups (7 rats in each group): 1st Group (control); 2nd Group T-10 (thymol 10 mg/kg), 3rd Group T-20 (thymol 20 mg/kg), 4th Group C-10 (carvacrol 10 mg/kg), 5th Group C-20 (carvacrol 20 mg/kg), 6th Group T + C-10 (thymol 10 mg/kg + carvacrol 10 mg/kg) and 7th Group T + C-20 (thymol 20 mg/kg + carvacrol 20 mg/kg). The duration of the experiment was 10 weeks for all animals. Read More

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Omega-3 attenuates high fat diet-induced kidney injury of female rats and renal programming of their offsprings.

Arch Physiol Biochem 2018 May 9:1-11. Epub 2018 May 9.

c Department of Medical Histology Faculty of Medicine , Cairo University , Cairo , Egypt.

Context: Maternal diet composition could influence fetal organogenesis.

Objective: We investigated effects of high fat diet (HFD) intake alone or combined with omega 3 during pregnancy, lactation and early days of weaning on nephrogenesis of pups and maternal renal function and morphology.

Material And Methods: Mothers and their pups included in each group were supplied with the same diet composition. Read More

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May 2018
5 Reads

Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies.

Arch Physiol Biochem 2018 May 9:1-9. Epub 2018 May 9.

c Faculty of Sciences, Department of Chemistry, Biochemistry Division , Ataturk University , Erzurum , Turkey.

Background: Paraoxonase 1 (PON1: EC 3.1.8. Read More

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May 2018
1 Read

Synergistic effect of cranberry extract and losartan against aluminium chloride-induced hepatorenal damage associated cardiomyopathy in rats.

Arch Physiol Biochem 2018 Apr 23:1-10. Epub 2018 Apr 23.

a Health Radiation Research Department , National Center for Radiation Research and Technology, Atomic Energy Authority , Nasr City, Cairo , Egypt.

The present study was designed to evaluate the effect of cranberry extract (CRAN) and/or losartan (LOS) against aluminium chloride (AlCl) induced hepatorenal damage associated cardiomyopathy in rats. To induce hepatorenal and cardiotoxicity, animals were received (AlCl; 70 mg/kg i.p. Read More

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April 2018
2 Reads

Effect of carbohydrate-electrolyte consumption on insulin, cortisol hormones and blood glucose after high-intensity exercise.

Arch Physiol Biochem 2018 Apr 21:1-7. Epub 2018 Apr 21.

a Faculty of Sports Sciences , Sinop University , Sinop , Turkey.

Objective: This study aimed to examine the effect of CHO-E consumption after high-intensity exercise on insulin, cortisol hormones and blood glucose responses, which is important for performance and recovery in athletes.

Methods: Sixteen volunteers, male athletes, participated into this study. Athletes were divided into two groups as experiment (CHO-E) and placebo (PLA). Read More

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April 2018
3 Reads

Effect of diet with carbohydrate but without daily energy restriction on serum glucose, lactate, and selected mineral and lipid levels in streptozotocin-induced experimental diabetic rats.

Arch Physiol Biochem 2018 Apr 21:1-6. Epub 2018 Apr 21.

b Department of Physiology, School of Medicine , Bezmialem Vakif University , Istanbul , Turkey.

Objective: Type I diabetes is a disease characterised by an extreme reduction in serum insulin levels. Diet and exercise have gained considerable attention in the treatment of diabetes. Therefore, this study was carried out to investigate the effect of diet with carbohydrate but without daily energy restriction on various metabolites (glucose, triglycerides, cholesterol, lactate), some electrolytes (Ca, Mg, Na, K, P, Cl) and essential metals (Mn, Co, Cu, Se, Zn, Fe) in the blood of rats with streptozotocin-induced diabetes. Read More

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April 2018
4 Reads

Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis - new tools for cancer treatment.

Arch Physiol Biochem 2018 Apr 17:1-6. Epub 2018 Apr 17.

g Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences , Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS) , Allahabad , Uttar Pradesh, India.

HCC has been reported to be immensely occurring carcinoma worldwide. Recent days the mortality occurred due to liver cancer has also been found to be increased at an alarming speed affecting mostly the young patients. The aim of the current study was to decipher the role of calcium and vitamin K3 in the treatment of chemically induced hepatocarcinogenesis in the male Wistar rats. Read More

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April 2018
2 Reads

Antioxidant and hepato-preventive effect of Citrus aurantium extract against carbon tetrachloride-induced hepatotoxicity in rats and characterisation of its bioactive compounds by HPLC-MS.

Arch Physiol Biochem 2018 Apr 17:1-12. Epub 2018 Apr 17.

a Biotechnology and Plant Improvement Laboratory , Centre of Biotechnology of Sfax , Sfax , Tunisia.

The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Read More

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April 2018
7 Reads

A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice.

Authors:
Fanwei Meng

Arch Physiol Biochem 2018 Apr 10:1-11. Epub 2018 Apr 10.

a Department of Anatomy and Physiology , Shandong College of Traditional Chinese Medicine , Yantai , China.

Context: Renal ischaemia reperfusion (I/R) is a common clinical condition with a high morbidity and mortality rate. To date, I/R-induced renal injury remains an ineffective treatment.

Objective: We hypothesis that angiogenesis and lymphangiogenesis markers, prospero homeobox-1 (PROX-1) and lymphatic endothelial hyaluronan receptor-1 (LYVE-1), are critical during I/R. Read More

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April 2018
3 Reads

Chronic testosterone administration improves cardiac contractility and has a beneficial effect on the haemostatic system by enhancing fibrinolytic activity and inducing hypocoagulation in healthy rats.

Arch Physiol Biochem 2018 Apr 4:1-10. Epub 2018 Apr 4.

b Kind Abdullah International Medical Research Center (KAIMRC) , Riyadh , KSA.

This study investigated the effects of chronic supraphysiological dose of testosterone propionate administration cardiovascular function in rats from the perspective of haemostatic function including platelet functions, coagulation, and fibrinolysis. Testosterone significantly enhanced cardiac contractility by enhancing LVSP (10%), dp/dt (36.7%), dp/dt (14. Read More

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April 2018
4 Reads

The antioxidant system in the soleus muscle of growing rats is stimulated by the administration of a low-protein/high-carbohydrate diet.

Arch Physiol Biochem 2018 Mar 29:1-8. Epub 2018 Mar 29.

a Department of Chemistry , Federal University of Mato Grosso , Cuiabá , Mato Grosso , Brazil.

The aim of this study was to evaluate the generation of reactive oxygen species (ROS) by xanthine oxidase (XO), the enzymatic antioxidant system and oxidative damage in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity by 45% and the activities of glutathione peroxidase (GPx), glutathione reductase and catalase in the soleus muscles. There was an increase in the carbonylated proteins with no increase thiobarbituric acid reactive substances (TBARS), although the XO activity had increased 20%. Read More

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March 2018
4 Reads

All trans retinoic acid modulates TNF-α and CYP2E1 pathways and enhances regression of ethanol-induced fibrosis markers in hepatocytes and HSCs in abstaining rodent model.

Arch Physiol Biochem 2018 Mar 28:1-9. Epub 2018 Mar 28.

a Department of Biochemistry , University of Kerala , Thiruvananthapuram , India.

Context: Our previous studies showed that all trans retinoic acid (ATRA) ameliorates alcohol-induced toxicity. Hence, we evaluated the efficacy of ATRA and abstention in the regression of alcohol-induced hepatotoxicity.

Materials And Methods: After ethanol administration to rats for 90 days, the regression of alcohol-induced toxicity was studied by supplementing ATRA at a dose of 100 μg/kg body weight for 30 days. Read More

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March 2018
1 Read

Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway.

Arch Physiol Biochem 2018 Mar 27:1-8. Epub 2018 Mar 27.

a Research Center for Molecular Medicine , Hamadan University of Medical Sciences , Hamadan , Iran.

Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of methanolic extract of F. pseudalliacea against human colon cancer HCT-116 cell line. Read More

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March 2018
5 Reads

Ventral tegmental area inactivation alters hormonal, metabolic, and locomotor responses to inescapable stress.

Arch Physiol Biochem 2018 Mar 26:1-9. Epub 2018 Mar 26.

b Neuroscience Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Context: The involvement of unilateral and bilateral inhibition of the ventral tegmental area (VTA) in response to stress is not well understood.

Objective: In the present study, the effect of unilateral and bilateral inhibition of the VTA on hormonal, metabolic, and locomotor responses to stress was assessed.

Material And Methods: Male rats seven days after cannulation into the VTA received electro foot-shock stress for seven consecutive days. Read More

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March 2018
2 Reads

Development of carbazole-bearing pyridopyrimidine-substituted urea/thiourea as polyphenol oxidase inhibitors: synthesis, biochemistry, and theoretical studies.

Arch Physiol Biochem 2018 Mar 23:1-7. Epub 2018 Mar 23.

c Chemistry Department , Sakarya University , Sakarya , Turkey.

Polyphenol oxidase (Tyrosinase, PPO) has received considerable attention, since it is the key enzyme in melanin biosynthesis. In this study, we investigated prepared novel carbazole-containing pyridopyrimidine-substituted with urea and thiourea derivatives and their PPO activities on the diphenolase activity of banana tyrosinase. The structures of the compounds synthesized were confirmed by 1 H NMR, 13 C NMR, FTIR and elemental analysis. Read More

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March 2018
12 Reads

The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study.

Arch Physiol Biochem 2018 Mar 22:1-9. Epub 2018 Mar 22.

d Department of Biochemistry , Anadolu University , Eskişehir , Turkey.

Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. Read More

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March 2018
3 Reads

Interactive effects of apelin, renin-angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats.

Arch Physiol Biochem 2018 Mar 22:1-11. Epub 2018 Mar 22.

a Physiology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.

Apelin and its receptor (APJ) are involved in the regulation of a variety of pathophysiological processes. We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS). Forty eight male albino rats were divided into two groups: control group and diabetic group. Read More

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March 2018
2 Reads

Genetic polymorphisms of TP53 Arg72Pro and Pro47Ser among Egyptian patients with colorectal carcinoma.

Arch Physiol Biochem 2018 Mar 21:1-8. Epub 2018 Mar 21.

b Department of Biochemistry , College of Science, Damietta University , New Damietta , Egypt.

Background: Previous reports demonstrated the role of TP53 gene polymorphisms with CRC risk among several ethnic populations. The purpose of this study is to assess the association of the TP53 Arg72Pro and Pro47Ser variants with CRC risk among Egyptian patients.

Subjects And Methods: This work was conducted on 120 unrelated CRC Egyptian patients who were compared to 140 healthy controls. Read More

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March 2018
3 Reads

Reversal of high fat diet-induced obesity through modulating lipid metabolic enzymes and inflammatory markers expressions in rats.

Arch Physiol Biochem 2018 Mar 19:1-7. Epub 2018 Mar 19.

a Department of Biochemistry , Centre for Biological Sciences, K. S. Rangasamy College of Arts and Science (Autonomous) , Tiruchengode , India.

In this study, we evaluated the ameliorative potential of Cucurbita maxima seeds oil (CSO (100 mg/kg body weight)) supplementation to high fat diet (HFD)-induced obese rats for 30 days on the changes in body weight, markers of lipid metabolism such as LDL, HDL, triglycerides, total cholesterol, adiponectin, leptin, amylase, and lipase. We also investigated the effects of CSO on the changes of lipid metabolic enzymes such as fatty-acid synthase, acetyl CoA carboxylase, carnitine palmitoyl transferase-1, HMG CoA reductase, and inflammatory markers (TNF-α and IL-6). Administration of CSO revealed significant diminution in body weight gain, altered the activity, expressions of lipid marker enzymes and inflammatory markers. Read More

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March 2018
2 Reads

Protective effect of Chaetomorpha gracilis aqueous extract against erythrocytes oxidative damage induced by high fat diet in treated mice.

Arch Physiol Biochem 2018 Mar 15:1-8. Epub 2018 Mar 15.

a Laboratory of Animal Physiology, Sfax Faculty of Sciences , University of Sfax , Sfax , Tunisia.

High fat diet (HFD) exposure is associated with various pathological dysfunctions, including haematological disorders and oxidative stress. The in vitro analysis of AECG revealed the presence of important levels of polyphenols and flavonoids, and denoted antioxidant capacities confirmed by nitric oxide radical (NO), reducing the power and HPLC chemical components' determinations. The animals exposed to HFD revealed a severe damage in the blood cells structure and haematological parameters accompanied with a significant decrease in serum Mg and Ca ATPase activities. Read More

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March 2018
7 Reads

Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy.

Arch Physiol Biochem 2018 Mar 14:1-9. Epub 2018 Mar 14.

e Department of Biochemistry , Govt. Medical College , Srinagar , India.

Development of diabetic nephropathy (DN) is directly linked to oxidative stress and inflammation. In this context, inflammatory and oxidative markers have gained much attention as targets for therapeutic intervention. We studied the effect of zingerone in a streptozotocin/high fat diet (STZ/HFD)-induced type 2 diabetic Wistar rat model. Read More

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March 2018
3 Reads

Cardioprotective effect of vitamin D on isoproterenol-induced myocardial infarction in diabetic rats.

Authors:
Sahar M El Agaty

Arch Physiol Biochem 2018 Mar 8:1-10. Epub 2018 Mar 8.

a Physiology Department, Faculty of Medicine , Ain Shams University , Cairo , Egypt.

Objectives: To assess the effect of vitamin D and to elucidate the underlying mechanisms on acute myocardial injury induced by isoproterenol (ISO) in diabetic rats.

Methods: Rats were divided into control rats, diabetic rats (DM), diabetic rats received ISO (DM-ISO), and diabetic rats pretreated with vitamin D and received ISO (DM-D-ISO).

Results: Vitamin D pretreatment significantly decreased fasting glucose and myocardial malondialdehyde, associated with increased insulin, myocardial glutathione and superoxide dismutase in DM-D-ISO versus DM-ISO. Read More

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March 2018
4 Reads

The impact of forced swimming on expression of RANKL and OPG in a type 2 diabetes mellitus rat model.

Arch Physiol Biochem 2018 Mar 2:1-6. Epub 2018 Mar 2.

a Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Objective: The importance of swimming in bone metabolism during type 2 diabetes (T2DM) is not well known. Receptor activator of nuclear factor-kB ligand (RANKL)/ osteoprotegerin (OPG) system as a critical pathway in bone remodeling may play a role in pathogenesis of T2DM. Hence, we tested this pathway and the possible beneficial effects of swim training on T2DM. Read More

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March 2018
3 Reads

Spirulina effect on modulation of toxins provided by food, impact on hepatic and renal functions.

Arch Physiol Biochem 2018 Feb 27:1-11. Epub 2018 Feb 27.

a Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology , University of Sciences and Technology Houari Boumediene (USTHB) , Algiers , Algeria.

Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an antioxidant treatment, on rats having ingested a diet rich in highly oxidised oil. Read More

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February 2018
8 Reads

Thymoquinone and fluoxetine alleviate depression via attenuating oxidative damage and inflammatory markers in type-2 diabetic rats.

Arch Physiol Biochem 2018 Feb 26:1-6. Epub 2018 Feb 26.

a Department of Pharmacology & Toxicology , College of Pharmacy, Jazan University , Gizan , K.S.A.

The study was designed to find out the effect of thymoquinone (TQ) alone and combination of TQ + fluoxetine in depression of type-2 diabetic rats. Glucose level was significantly decreased in TQ alone treated group, whereas no significant change was recorded when TQ was combined with fluoxetine. Administration of TQ alone and combination of TQ and fluoxetine significantly decreased immobility time, increased latency to immobility and increased locomotor activity. Read More

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February 2018
3 Reads

Mitigating effects of antioxidant properties of Artemisia herba alba aqueous extract on hyperlipidemia and oxidative damage in alloxan-induced diabetic rats.

Arch Physiol Biochem 2018 Feb 26:1-11. Epub 2018 Feb 26.

a Laboratory of Biochemistry and Environmental Toxicology , University of Badji Mokhtar , Annaba , Algeria.

Chronic hyperglycemia and excess reactive oxygen species overproduced in diabetes were associated with oxidative stress, led to continuous injury and functions damage to different organs: eyes, kidneys, neural and cardiovascular system. The present study was undertaken to evaluate the protective effect of Artemisia herba alba (AHA) leaf powder against alloxane-induced oxidative damage in diabetic rats. Rats were randomly divided into four groups: Group I controls received saline solution 9%; Group II was treated with 150 mg alloxane/(kg body weight) administered by intraperitoneal. Read More

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February 2018
4 Reads

The effect of troxerutin on anxiety- and depressive-like behaviours in the offspring of high-fat diet fed dams.

Arch Physiol Biochem 2018 Feb 26:1-7. Epub 2018 Feb 26.

a Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

This study aimed at investigating the metabolic and behavioural effects of troxerutin treatment in the offspring of high fat diet (HFD) fed dams. Female Wistar rats (n = 40) received normal diet (ND) or HFD for 8 weeks prior to breeding. After mating, pregnant animals were assigned to four subgroups: ND, ND + Tro (troxerutin 150 mg/kg/day), HFD, and HFD + Tro. Read More

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February 2018
4 Reads

Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess.

Arch Physiol Biochem 2018 Feb 27:1-10. Epub 2018 Feb 27.

a Department of Biochemistry and Biotechnology , Annamalai University , Annamalai Nagar , India.

Context: Endoplasmic reticulum (ER) stress in the liver is a pathological outcome of nutrient excess and is suggested to be one of the hits for progressive liver injury.

Objective: This study investigated whether grape seed proanthocyanidins (GSP) and metformin (MET) alone or in combination can relieve hepatic ER stress induced in rats subjected to calorie excess.

Material And Methods: Male albino Wistar rats were given high calorie diet (HCD) for 45 days, while GSP (100 mg/kg body weight) and MET (50 mg/kg body weight) were administered either alone or in combination for last 15 days. Read More

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February 2018
3 Reads

Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease.

Arch Physiol Biochem 2018 Feb 20:1-8. Epub 2018 Feb 20.

b Department of Anatomical Sciences, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.

Context: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder.

Objective: Effects of combined therapy with resveratrol, interval and continuous exercises on oxidative stress, inflammation, and apoptosis in the liver of rats with NAFLD.

Methods: NAFLD rats were organised in patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV groups. Read More

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February 2018
4 Reads

Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats.

Arch Physiol Biochem 2018 Feb 20:1-6. Epub 2018 Feb 20.

d Department of Physiology , Firat University , Elazig , Turkey.

There are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the anxiety/depression-like behaviours in male rats. Anxiety/depression-related behaviours were evaluated by use of forced swimming test and open field test. Read More

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February 2018
2 Reads

Survey of the effect of doxorubicin and flavonoid extract of white Morus alba leaf on apoptosis induction in a-172 GBM cell line.

Arch Physiol Biochem 2018 Feb 20:1-6. Epub 2018 Feb 20.

c Department of Medicinal Plants , Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences , Tehran , Iran.

In this study, the effect of doxorubicin, flavonoid extract of white Morus alba leaf (MFE) and a combination of doxorubicin and flavonoid extract on Bax and Bcl2 levels and caspase 3 activity of cancer A-172 GBM cell line was investigated. Bax/Bcl2 levels of treated A-172 GBM cell line with flavonoid extract of white mulberry leaf were estimated by ELISA methods. Caspase 3 activity of treated A-172 GBM cells was determined by calorimetric assay. Read More

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February 2018
3 Reads

Natural products for controlling hyperlipidemia: review.

Arch Physiol Biochem 2018 Feb 19:1-8. Epub 2018 Feb 19.

b Pharmacognosy Department, College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.

Hyperlipidemia is an abnormality of lipid metabolism, characterized by an elevation of total cholesterol, triglyceride, and low density lipoprotein-cholesterol, and/or a decreasing of high density lipoprotein cholesterol in circulating levels. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia-associated lipid disorders are considered the cause of atherosclerotic cardiovascular disease. Read More

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February 2018
2 Reads

The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K channel.

Arch Physiol Biochem 2018 Feb 18:1-8. Epub 2018 Feb 18.

b Faculty of Arts and Science, Department of Biology , Abant İzzet Baysal University , Bolu , Turkey.

Context: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial K channel in the possible anti-arrhythmic actions of the treatments.

Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p. Read More

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February 2018
6 Reads

Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.

Arch Physiol Biochem 2018 Feb 15:1-11. Epub 2018 Feb 15.

h Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

Context: Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear.

Objective: To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway.

Materials And Methods: Rats were divided into control, sham, sham + ghrelin, myocardial infarction (MI), and MI + ghrelin groups. Read More

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February 2018
3 Reads

Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance.

Arch Physiol Biochem 2018 Feb 13:1-6. Epub 2018 Feb 13.

a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis.

Material And Methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11 week until being sacrificed, on Week 15. Read More

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February 2018
2 Reads

Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na/K-ATPase.

Authors:
Salah O Bashir

Arch Physiol Biochem 2018 Feb 13:1-10. Epub 2018 Feb 13.

a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.

This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g), and T1DM + RES + insulin and treated for eight weeks. While individual administrations of both drugs significantly but partially restored renal function and cortex architectures, combination therapy of both RES and insulin produced the maximum improvements. Read More

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February 2018
3 Reads

High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome.

Arch Physiol Biochem 2018 Feb 12:1-7. Epub 2018 Feb 12.

b Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas , Universidade Federal de Santa Maria , Santa Maria , Brazil.

This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VOmax), and lipid profile were assessed before and after HIIT. Read More

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February 2018
7 Reads

Cytoprotective and antioxidant effects of the red alga Alsidium corallinum against hydrogen peroxide-induced toxicity in rat cardiomyocytes.

Arch Physiol Biochem 2018 Feb 12:1-9. Epub 2018 Feb 12.

d ORPHY, Optimization of Physiological Regulation, EA4324, Faculty of Medicine and Health Sciences , University of Western Brittany , Brest , France.

Context: Sepsis is the manifestation of the immune and inflammatory responses to infection that may ultimately result in multiorgan failure. Many substances are involved in myocardial dysfunction in sepsis, including hydrogen peroxide.

Objective: This study evaluates the protective activity of the red alga Alsidium corallinum against hydrogen peroxide (HO)-induced toxicity in H9c2 cardiomyocytes. Read More

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February 2018
17 Reads

Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation.

Arch Physiol Biochem 2018 Feb 10:1-15. Epub 2018 Feb 10.

c Department of Medical Biochemistry, College of Medicine , King Khalid University , Abha , Saudi Arabia.

This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Read More

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February 2018
3 Reads

The enhancement of serotonin-induced contraction of rat femoral artery is mediated by angiotensin II release from intact endothelium.

Arch Physiol Biochem 2018 Feb 10:1-12. Epub 2018 Feb 10.

a Department of Pharmacology, Clinical Pharmacology and Toxicology; Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

We have performed an in vitro study on isolated intact or denuded femoral artery (FA) of healthy, diabetic, and/or rats submitted to the FA occlusion. The aim was to determine the contribution of endothelium and endothelial dysfunction (ED) on serotonin-induced action in FA. Further, the contribution of angiotensin II and cyclooxygenase products of arachidonic acid was investigated. Read More

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February 2018
4 Reads

Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats.

Arch Physiol Biochem 2018 Feb 9:1-8. Epub 2018 Feb 9.

c Medical Plants Research Center, Basic Health Sciences Institute , Shahrekord University of Medical Sciences , Shahrekord , Iran.

Context: Toxicity with paraquat can lead to serious damages to the liver.

Objective: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage.

Material And Methods: Rats were divided into six groups. Read More

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February 2018
5 Reads

New lower cutoff for serum high sensitive C-reactive protein in obese women indicates the risk of metabolic syndrome.

Arch Physiol Biochem 2018 Feb 2:1-5. Epub 2018 Feb 2.

c Department of Public Health , Poznan University of Medical Sciences , Poznań , Poland.

Objective, materials and methods: The aim of this cross-sectional study with a consecutive enrolment was to analyse the role of high sensitive C-reactive protein (hs-CRP) measurement in similarly obese patients with and without the metabolic syndrome (MS).

Results: In total, 589 obese patients were screened, of whom 138 aged 50-75 years were enrolled. The others were rejected due to strict criteria of enrolment, so that the group was highly homogenous in numerous clinical aspects. Read More

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February 2018
5 Reads