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    1 OF 18

    In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney.
    Arch Physiol Biochem 2017 Sep 18:1-11. Epub 2017 Sep 18.
    a Animal Eco-Physiology Laboratory, Sciences Faculty of Sfax , Université de Sfax , Sfax , Tunisia.
    The present study investigated the in vitro and the in vivo antioxidant capacities of Allium sativum (garlic) extract against deltamethrin-induced oxidative damage in rat's brain and kidney. The in vitro result showed that highest extraction yield was achieved with methanol (20.08%). Read More

    Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3β/NRF-2 signalling pathway.
    Arch Physiol Biochem 2017 Sep 14:1-9. Epub 2017 Sep 14.
    a Radiation Biology Department, National Centre for Radiation Research and Technology , Atomic Energy Authority , Cairo , Egypt.
    This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide or γ-radiation-induced neurotoxicity. To induce brain damage, animals were received acrylamide (25 mg/kg b.wt. Read More

    Effects of co-exposure to imidacloprid and gibberellic acid on redox status, kidney variables and histopathology in adult rats.
    Arch Physiol Biochem 2017 Sep 6:1-10. Epub 2017 Sep 6.
    a Animal Physiology Laboratory, Research Unit of Toxicology and Environmental Health, Sfax Faculty of Sciences , University of Sfax , Sfax , Tunisia.
    Data on the individual nephrotoxic effects of imidacloprid (IMI) and gibberellic acid (GA3) are scarce. Moreover, there is a lack of information about their combined effects on the renal tissue. Our study investigated the effects of IMI and GA3 separately or together on rats kidney. Read More

    Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
    Arch Physiol Biochem 2017 Sep 3:1-10. Epub 2017 Sep 3.
    a Cardiovascular Research Laboratory, Department of Physiology , University of Ilorin, Ilorin, Nigeria.
    Context: Cigarette smoking is considered to be a major risk factor for the development of diabetes and cardiovascular disease. Oestrogen-progestin combined oral contraceptive (COC) use has been associated with adverse cardiometabolic events.

    Objective: We hypothesized that nicotine would ameliorate insulin resistance (IR) that is accompanied by decreased cardiac glycogen synthase kinase-3 (GSK-3) and plasminogen activator inhibitor-1 (PAI-1). Read More

    Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects.
    Arch Physiol Biochem 2017 Sep 1:1-12. Epub 2017 Sep 1.
    b Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
    We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated from musculus vastus lateralis from healthy males with varying degrees of maximal oxygen uptake. Trained and intermediary trained subjects showed higher carbohydrate oxidation in vivo. Fibre-type distribution in biopsies and myotubes did not differ between groups. Read More

    Antiplatelets and profibrinolytic activity of Citrullus colocynthis in control and high-fat diet-induced obese rats: mechanisms of action.
    Arch Physiol Biochem 2017 Aug 31:1-11. Epub 2017 Aug 31.
    a Department of Clinical Laboratory Sciences, College of Applied Medical Sciences , King Saud Bin Abdulaziz University for Health Sciences , Riyadh , Saudi Arabia.
    The current study aimed to investigate the effect of Citrullus colocynthis (C. colocynthis) hydro-alcoholic extract on blood haemostasis in control and high-fat diet (HFD) induced obese rats. In control rats, the extract significantly enhanced bleeding time and plasma levels of tPA and significantly decreased plasma levels PAI-1 and serum levels of thromboxane B2 leading to inhibition of platelets aggregation. Read More

    High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women.
    Arch Physiol Biochem 2017 Aug 31:1-7. Epub 2017 Aug 31.
    b Department of Internal Medicine , Trakya University Medical Faculty , Edirne , Turkey.
    The aim of this study was to investigate the plasma adipokine responses to high-intensity interval training (HIT) in overweight/obese women. Twelve women (age 21.7 ± 3. Read More

    Supplementation of all trans retinoic acid ameliorates ethanol-induced endoplasmic reticulum stress.
    Arch Physiol Biochem 2017 Aug 31:1-8. Epub 2017 Aug 31.
    a Department of Biochemistry , University of Kerala , Thiruvananthapuram , Kerala , India.
    Context: Molecular pathogenesis of chronic alcoholism is linked to increased endoplasmic reticulum stress. Ethanol is a competitive inhibitor of vitamin A metabolism and vitamin A supplementation aggravates existing liver problems. Hence, we probed into the impact of supplementation of all trans retinoic acid (ATRA), the active metabolite of vitamin A on ethanol-induced endoplasmic reticulcum stress. Read More

    Refeeding after caloric restriction reverses altered liver glucose release.
    Arch Physiol Biochem 2017 Aug 30:1-4. Epub 2017 Aug 30.
    a Department of Physiological Sciences , State University of Maringá , Maringá , Brazil.
    Context: Caloric restriction increases liver glucose release (LGR), but it is not known if this is a permanent condition.

    Objective: To investigate if refeeding after caloric restriction reverses the high LGR.

    Materials And Methods: Rats were organised in six-pups litters (GC); 12-pups litters with either 50% caloric restriction from 21 to 80 days of age (GR) or fed at will from 50 to 80 days of age (GRL). Read More

    Combined effect of retinoic acid and calcium on the in vitro differentiation of human adipose-derived stem cells to adipocytes.
    Arch Physiol Biochem 2017 Aug 29:1-10. Epub 2017 Aug 29.
    f Department of Immunology, School of Public Health , Tehran University of Medical sciences , Tehran , Iran.
    Context: It has been shown that adipogenesis can be modulated by factors such as all-trans retinoic acid (ATRA) and calcium.

    Objective: To determine, the combined effect of ATRA and calcium on the differentiation of human adipose-derived stem cells (hADSCs).

    Methods: Mesenchymal stem cells (MSCs) were differentiated into the adipocytes by 0. Read More

    Really does temperature reduction and norepinephrine have similar effects on the energy metabolism in rat brown adipose tissue?
    Arch Physiol Biochem 2017 Aug 26:1-7. Epub 2017 Aug 26.
    a Department of Medicine, School of Medicine , Universidad Complutense de Madrid , Madrid , Spain.
    Context: Heat generation by brown adipose tissue (BAT) in response to temperature reduction seems to be entirely related to sympathetic nervous stimulation.

    Objective: To analyse if temperature reduction and norepinephrine may differently affect the expression of proteins related to energy metabolism in BAT.

    Materials And Methods: Isolated rats BAT was incubated with/without norepinephrine (10(-6) mol/L, 24 h at 32 °C and 37 °C). Read More

    IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.
    Arch Physiol Biochem 2017 Aug 24:1-12. Epub 2017 Aug 24.
    a Clore Laboratory , University of Buckingham , Buckingham , UK.
    Regulation of the expression of GPCR fatty acid receptor genes has been examined in human adipocytes differentiated in culture. TNFα and IL-1β induced a marked reduction in GPR120 expression, mRNA level falling 17-fold at 24 h in adipocytes incubated with TNFα. In contrast, GPR84 mRNA was dramatically increased by these cytokines (>500-fold for IL-1β at 4 h); GPR41 expression was also stimulated. Read More

    Preclinical renal chemo-protective potential of Prunus amygdalus Batsch seed coat via alteration of multiple molecular pathways.
    Arch Physiol Biochem 2017 Aug 24:1-9. Epub 2017 Aug 24.
    a Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences , Sam Higginbottom University of Agriculture, Technology & Sciences , Allahabad , India.
    Prunus amygdalus Batsch (almond) is a classical nutritive traditional Indian medicine. Along with nutritive with anti-oxidant properties, it is, clinically, used in the treatment of various diseases with underlying anti-oxidant mechanism. This study is an effort to scrutinise the renal protective effect of P. Read More

    Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats.
    Arch Physiol Biochem 2017 Aug 17:1-8. Epub 2017 Aug 17.
    a Department of Chemistry, Faculty of Science and Art , Adiyaman University , Adiyaman , Turkey.
    In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. Read More

    Carbonic anhydrase I-II autoantibodies and oxidative status in long-term follow-up of patients with Crimean-Congo haemorrhagic fever.
    Arch Physiol Biochem 2017 Aug 10:1-6. Epub 2017 Aug 10.
    d Department of Infectious Diseases and Clinical Microbiology, Medical Faculty , Karadeniz Technical University , Trabzon , Turkey.
    Context: Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease.

    Objective: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I-II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF.

    Methods: Seventy CCHF patients and 39 healthy control volunteers were included in the study. Read More

    Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles.
    Arch Physiol Biochem 2017 Aug 9:1-8. Epub 2017 Aug 9.
    b Department of Chemistry, Faculty of Arts and Sciences , Gaziosmanpasa University , Tokat , Turkey.
    The new 1-(4-(3-(aryl)acryloyl)phenyl)-1H-pyrrole-2,5-diones (5a-g) were prepared from 4'-aminchalcones (3a-g) and screened for biological activities. All compounds (3a-g and 5a-g), except 3d and 3e displayed good cytotoxic activities with IC50 values in the range of 7.06-67. Read More

    Early detection of macular and peripapillary changes with spectralis optical coherence tomography in patients with prediabetes.
    Arch Physiol Biochem 2017 Aug 5:1-5. Epub 2017 Aug 5.
    a Department of Ophthalmology, School of Medicine , Dicle University , Diyarbakir , Turkey.
    Purpose: To compare the retina ganglion cell complex (GCC) layer and peripapillary nerve fibre layer thickness (pRNFL) in patients with prediabetes and healthy subjects analysed by spectral domain optical coherence tomography (SD-OCT).

    Methods: This cross-sectional and comparative study included prediabetic patients and healthy subjects. All participants underwent SD-OCT measurement of pRNFL thickness, and GCC thickness. Read More

    The interactions of cephalosporins on polyol pathway enzymes from sheep kidney.
    Arch Physiol Biochem 2017 Jul 31:1-10. Epub 2017 Jul 31.
    b Department of Biochemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey.
    Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.

    Objective: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. Read More

    Rapamycin mitigates erythrocyte membrane transport functions and oxidative stress during aging in rats.
    Arch Physiol Biochem 2017 Jul 31:1-9. Epub 2017 Jul 31.
    a Department of Biochemistry , University of Allahabad , Allahabad , India.
    Erythrocyte membrane is a suitable model to study various metabolic and physiological functions as it undergoes variety of biochemical changes during aging. An age-dependent modulatory effect of rapamycin on erythrocyte membrane functions is completely unknown. Therefore, the present study was undertaken to investigate the effect of rapamycin on age-dependent impaired activities of transporters/exchangers, altered levels of redox biomarkers, viz. Read More

    Cytoprotective effects of essential oil of Pinus halepensis L. against aspirin-induced toxicity in IEC-6 cells.
    Arch Physiol Biochem 2017 Jul 18:1-7. Epub 2017 Jul 18.
    a Laboratory ORPHY EA4324, UFR Sciences et Technique , Université de Bretagne Occidentale 6 Avenue Le gorgeu , Brest , France.
    Context: Essential oils from Pinus species have been reported to have various therapeutic properties.

    Objective: This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. Read More

    Protective effect of Teucrium polium on carbon tetrachloride induced genotoxicity and oxidative stress in rats.
    Arch Physiol Biochem 2017 Jul 16:1-9. Epub 2017 Jul 16.
    a Laboratory of Histology , Medicine Faculty of Sfax University , Sfax , Tunisia.
    This study aimed to investigate the protective effects of Teucrium polium (TP) on carbon tetrachloride (CCl4) induced spleen, erythrocyte's oxidative stress, and genotoxicity in rats. TP was found to contain large amounts of polyphenols (150 mg GAE/G of dry plant) and flavonoids (60 mg QE/g of quercetin dry plant). The CCl4 (0. Read More

    Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats.
    Arch Physiol Biochem 2017 Jul 14:1-8. Epub 2017 Jul 14.
    a Histology-Embryology Laboratory , Sfax Faculty of Medicine , Sfax , Tunisia.
    Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Read More

    Arecoline cannot alter testicular dysfunction and pineal activation caused by noise in wistar rat.
    Arch Physiol Biochem 2017 Jul 13:1-9. Epub 2017 Jul 13.
    a Department of Zoology , University of Calcutta , Kolkata , India.
    Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Read More

    A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats.
    Arch Physiol Biochem 2017 Jul 12:1-12. Epub 2017 Jul 12.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated the protective effect of subacute pre-adminsitration of either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) in rats and illustrates the possible mechanisms of action. While solely pre-administration of Se or Tau resulted in partial amelioration in all of the measured parameters in MI rats, concomitant administration of both drugs to MI rats significantly restored contractility function by increasing LVSP and decreasing LVEDP and significantly normalized serum levels of LDH, CK-MB and BNP and restored normal cardiac architecture. This concomitant treatment acted by increasing the activity of major antioxidant enzymes (SOD and GPx), decreasing the levels of inflammatory markers including TNF-α, IL-6 as well as levels of Bcl-2 and caspase-3 and downregulating mRNA levels of Bax and P53, markers of apoptosis. Read More

    Exendin-4, a glucagon-like peptide-1 receptor agonist downregulates hepatic receptor for advanced glycation end products in non-alcoholic steatohepatitis rat model.
    Arch Physiol Biochem 2017 Jul 11:1-8. Epub 2017 Jul 11.
    b Biochemistry Department, Faculty of Medicine , Benha University , Benha , Egypt.
    Context: Exendin-4, a glucagon-like peptide-1 receptor agonist has been shown to have curative effects on hepatic steatosis in murine models.

    Objective: The present study aimed to elucidate the effect of Exendin-4 on hepatic receptor for advanced glycation end products (RAGE) mRNA expression in non-alcoholic steatohepatitis (NASH) rat model induced by high-fat diet.

    Methods: NASH was induced by high-fat diet intake, and Exendin-4 was given in two different doses. Read More

    Potential protective effects of polysaccharide extracted from Ulva lactuca against male reprotoxicity induced by thiacloprid.
    Arch Physiol Biochem 2017 Jul 10:1-10. Epub 2017 Jul 10.
    a Unit of Functional Genomics and Plant Physiology , Higher Institute of Biotechnology of Sfax , Sfax , Tunisia.
    Context: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values.

    Objective: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system.

    Materials And Methods: Rats were exposed either to THC, THC + PS (100 mg/kg), or THC + PS (200 mg/kg). Read More

    The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population.
    Arch Physiol Biochem 2017 Jul 10:1-6. Epub 2017 Jul 10.
    a Department of Chemistry and Biochemistry, Medical Faculty , Trakia University , Stara Zagora , Bulgaria.
    Chronic inflammation and remodelling of the small airways are features related to chronic obstructive pulmonary disease (COPD). In the current study, we aimed to explore the possible role of MMP12 -82 A > G (rs2276109) promoter polymorphism in the development of COPD in a population from Bulgaria (167 patients with COPD and 119 control individuals). The genotype and allele distributions differed significantly between COPD patients and controls (p = . Read More

    Elevated resting heart rate is associated with the severity of coronary artery disease in non-treated patients who underwent coronary angiography: potential role of lipoprotein subfractions.
    Arch Physiol Biochem 2017 Jul 7:1-8. Epub 2017 Jul 7.
    a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China.
    Objective: To assess the association between resting heart rate (RHR) and lipoprotein subfractions to provide potential evidence for the relationship between RHR and severity of CAD.

    Methods: A total of 1119 consecutive non-treated subjects scheduled for coronary angiography were enrolled. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) separation were performed by Lipoprint System. Read More

    Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian patients.
    Arch Physiol Biochem 2017 Jun 18:1-4. Epub 2017 Jun 18.
    a Department of Biochemistry, Faculty of Pharmacy , Suez Canal University , Ismailia , Egypt.
    Context: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.

    Objective: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. Read More

    Modulatory effect of garcinol in streptozotocin-induced diabetic Wistar rats.
    Arch Physiol Biochem 2017 Jun 9:1-8. Epub 2017 Jun 9.
    b Department of studies in Zoology , University of Mysore , Mysuru , Karnataka (S) , India.
    The objective of the study was to evaluate the efficacy of garcinol as an antidiabetic candidate in streptozotocin-induced diabetic Wistar rats. Diabetic rats showed a significant increase in the biochemical parameters such as fasting blood glucose, glycated haemoglobin, urea, alanine aminotransferase and aspartate aminotransferase, malondialdehyde, total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index and a significant decrease in plasma insulin, HOMA-β-cell functioning index, glycogen, high-density lipoprotein cholesterol, body weight and antioxidant enzyme activities, viz. superoxide dismutase, catalase and reduced glutathione. Read More

    Synthesis and carbonic anhydrase inhibitory properties of newspiroindoline-substituted sulphonamide compounds.
    Arch Physiol Biochem 2017 May 31:1-7. Epub 2017 May 31.
    b Faculty of Arts and Sciences, Chemistry Department , Balikesir University , Balikesir , Turkey.
    New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of the 14 synthesised sulphonamides (6a-n) on esterase activities of these isoenzymes were studied in vitro. Read More

    In vivo anti-inflammatory activity of aqueous extract of Teucrium polium against carrageenan-induced inflammation in experimental models.
    Arch Physiol Biochem 2017 May 30:1-9. Epub 2017 May 30.
    a Histology-Embryology Laboratory , Sfax Faculty of Medicine, University of Sfax , Sfax , Tunisia.
    The aim of this study was to evaluate the anti-inflammatory activity of Teucrium polium (TP). Rats were divided into four groups: group 1 controls received standard diet; group 2 inflamed by carrageenan (Carr) (1% Carr); group 3 as reference inflamed with Carr and treated with Indometacine (Ind) (150 mg/kg bw) and group 4 inflamed with Carr and pre0treated with TP (5 g/L). Oedema volume was measured 1 h to 5 h after injection. Read More

    Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism.
    Arch Physiol Biochem 2017 May 16:1-4. Epub 2017 May 16.
    d Medical Check-up Center , Tachikawa General Hospital , Nagaoka , Japan.
    Context: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA).

    Objective: To investigate the association between ketonuria and LSA. Read More

    Early-onset obesity and food restriction alter hepatocyte metabolism in adult Wistar rats.
    Arch Physiol Biochem 2017 May 13:1-9. Epub 2017 May 13.
    e Department of Physiological Sciences , State University of Maringá , Maringa, Brazil.
    Context: Caloric restriction (CR) is suggested for overweight control.

    Objective: Systemic and liver glucose metabolism in the reduced-litter (RL) rat model under 30% CR was investigated.

    Materials And Methods: Newborn litters were organised in control (G9); RL with free diet (G3L); and RL with CR (G3R). Read More

    Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure.
    Arch Physiol Biochem 2017 May 8:1-7. Epub 2017 May 8.
    a Department of Physiology, Cardiovascular Research Laboratory , College of Health Sciences, University of Ilorin , Ilorin , Nigeria.
    Context: Elevated gestational circulating testosterone has been associated with pathological pregnancies that increase the risk of development of cardiometabolic disorder in later life.

    Objective: We hypothesised that gestational testosterone exposure, in late pregnancy, causes glucose deregulation and atherogenic dyslipidaemia that would be accompanied by high plasminogen activator inhibitor-1 (PAI-1). The study also hypothesise that low-dose spironolactone treatment would ameliorate these effects. Read More

    Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters.
    Arch Physiol Biochem 2017 Oct 1;123(4):265-278. Epub 2017 May 1.
    b Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Rajah Muthiah Dental College and Hospital , Annamalai University , Annamalainagar , Tamilnadu , India.
    In recent years, researchers have been focused on citrus flavanone, a naturally occurring bioactive substance of hesperetin. To investigate the molecular mechanism based chemopreventive efficacy of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch (HBP) squamous cell carcinoma (SCC). The oral tumour was provoked by painted with 0. Read More

    Genetic polymorphisms of IL-23R (rs7517847) and LEP (rs7799039) among Egyptian patients with hepatocellular carcinoma.
    Arch Physiol Biochem 2017 Apr 28:1-7. Epub 2017 Apr 28.
    b Genetics Unit , Children Hospital, Mansoura University , Mansoura , Egypt.
    Background: Genetic polymorphisms of IL-23 R (rs7517847) and LEP (rs7799039) have been stated to be associated with various types of human cancers. The purpose of this work is to test the association of these genetic polymorphisms with hepatocellular carcinoma (HCC) among Egyptian patients.

    Subjects And Methods: This study involved 150 unrelated Egyptian HCC patients in addition to 100 healthy controls from the same locality. Read More

    Camelus dromedarius glucose transporter 4: in silico analysis, cloning, expression, purification and characterisation in E. coli.
    Arch Physiol Biochem 2017 Oct 25;123(4):254-264. Epub 2017 Apr 25.
    a Protein Research Chair, Department of Biochemistry, College of Science , King Saud University , Riyadh , Saudi Arabia.
    Camels have exceptional carbohydrate metabolism as their plasma glucose level is high and have low whole body insulin sensitivity, similar to that observed in type 2 diabetes patients. We aimed at studing an important component of insulin signalling pathway, the GLUT4, in camel. Camelus dromedarius GLUT4 (CdGLUT4) CDS is 1530 nucleotide in length that encodes for a 55KDa protein. Read More

    Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines.
    Arch Physiol Biochem 2017 Oct 20;123(4):238-248. Epub 2017 Apr 20.
    a Department of Surgery , University of Auckland , Auckland , New Zealand.
    Background: The prevalence of metabolic diseases continues to rise worldwide, with a growing recognition of metabolic dysregulation after acute inflammatory diseases such as acute pancreatitis (AP). Adipokines and cytokines play an important role in metabolism and the course of AP, but there is a paucity of research investigating their relationship with pancreatic hormones after AP. This study aimed to explore associations between pancreatic hormones and adipokines as well as cytokines to provide insights into the pathophysiology of altered pancreatic hormone secretion following AP. Read More

    Polysaccharides extraction from Opuntia stricta and their protective effect against HepG2 cell death and hypolipidaemic effects on hyperlipidaemia rats induced by high-fat diet.
    Arch Physiol Biochem 2017 Oct 3;123(4):225-237. Epub 2017 Apr 3.
    a Laboratory of Pharmacology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia.
    The aim of this study was to analyse cytoprotective effect of polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose was the dominant monosaccharides (30. Read More

    Reduced expression of adipose triglyceride lipase decreases arachidonic acid release and prostacyclin secretion in human aortic endothelial cells.
    Arch Physiol Biochem 2017 Oct 3;123(4):249-253. Epub 2017 Apr 3.
    a Institute of Molecular Biology and Biochemistry , Center of Molecular Medicine , Graz , Austria.
    Background: Vascular endothelial cells represent an important source of arachidonic acid (AA)-derived mediators involved in the generation of anti- or proatherogenic environments. Evidence emerged (in mast cells), that in addition to phospholipases, neutral lipid hydrolases as adipose triglyceride lipase (ATGL) also participate in this process.

    Objective: To examine the impact of ATGL on AA-release from cellular phospholipids (PL) and on prostacyclin secretion in human aortic endothelial cells (HAEC). Read More

    Liver injury following small intestinal ischemia reperfusion in rats is attenuated by Pistacia lentiscus oil: antioxidant and anti-inflammatory effects.
    Arch Physiol Biochem 2017 Oct 24;123(4):199-205. Epub 2017 Mar 24.
    a Department of Life Sciences , Laboratory of Animal Ecophysiology, University of Sfax , Sfax , Tunisia.
    Context: Intestinal ischemia-reperfusion (IIR) not only leads to severe intestine damage but also induced subsequent destruction of remote organs.

    Objective: We investigated the protective effect of Pistascia lentiscus L. (Anacardiaceae) oil on IIR. Read More

    Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin.
    Arch Physiol Biochem 2017 Oct 24;123(4):219-224. Epub 2017 Mar 24.
    b Faculty of Veterinary, Department of Biochemistry , Ataturk University , Erzurum , Turkey.
    The aim of this study is to purify carbonic anhydrase I and II isoenzymes from human erythrocyte, isolate two natural products osajin (OSJ) and pomiferin (PMF) from Maclura pomifera fruits, and evaluate the in vitro effect of these natural metabolites on these isoenzymes. These natural products may be used as starting points for drug discovery (like drugs used in several therapeutic applications, including antiglaucoma activity). For the purification procedure, the Sepharose-4B-l-tyrosine-sulphonamide affinity chromatography was used. Read More

    Black tea supplementation augments redox balance in rats: relevance to aging.
    Arch Physiol Biochem 2017 Oct 23;123(4):212-218. Epub 2017 Mar 23.
    a Department of Biochemistry , University of Allahabad , Allahabad , India.
    Several health beneficial effects have been attributed to tea consumption, most of the effects are due to the strong antioxidant property of tea catechins. The present study evaluates the effect of black tea extract (BTE) supplementation on the redox balance of rats at different stages in their life span. We have evaluated erythrocyte and plasma redox status in young (4 months), middle-aged (12 months) and old-aged (24 months) male Wistar rats, by quantifying an array of parameters linked to redox status. Read More

    Effects of exercise training on kinin receptors expression in rats with myocardial infarction.
    Arch Physiol Biochem 2017 Oct 23;123(4):206-211. Epub 2017 Mar 23.
    a Department of Rehabilitation Medicine , Affiliated Zhongshan Hospital of Dalian University , Dalian , China.
    Objectives: The objective of this study is to determine the role of kinin B1 and B2 receptors in exercise-induced cardiac muscle angiogenesis.

    Method: Thirty Wistar rats were randomly assigned to the control group, the myocardial infarction group and the exercise training group (myocardial infarction model was made and received 30 min exercise training on a treadmill). After 4 weeks of experiment, cardiac muscle was harvested. Read More

    Chemically induced hypoxia promotes differential outcomes over preadipocyte- or adipocyte-macrophage communication.
    Arch Physiol Biochem 2017 Jul 14;123(3):175-181. Epub 2017 Feb 14.
    a Department of Nutrition , Faculty of Medicine, University of Chile , Santiago , Chile.
    Expansion of white adipose tissue induce insufficient vascularization, driving hypoxia and low-grade inflammation. Resident preadipocytes are thought to be involved. We evaluated the effects of hypoxia over preadipocytes and adipocytes, to determine which cellular type impacts the most over macrophages activation. Read More

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