1,298 results match your criteria Archives Of Physiology And Biochemistry [Journal]


Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus.

Arch Physiol Biochem 2020 Jul 9:1-10. Epub 2020 Jul 9.

Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran.

Background: The coronavirus disease 2019 (COVID-19) is a pandemic caused by coronavirus with mild to severe respiratory symptoms. This paper aimed to investigate the effect of nutrients on the immune system and their possible roles in the prevention, treatment, and management of COVID-19 in adults.

Methods: This Systematic review was designed based on the guideline of the Preferred Reporting for Systematic Reviews (PRISMA). Read More

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http://dx.doi.org/10.1080/13813455.2020.1791188DOI Listing

The effect of simvastatin on gene expression of low-density lipoprotein receptor, sterol regulatory element-binding proteins, stearoyl-CoA desaturase 1 mRNA in rat hepatic tissues.

Arch Physiol Biochem 2020 Jul 9:1-8. Epub 2020 Jul 9.

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University Medical Sciences, Gorgan, Iran.

The study aimed to assess the effect of simvastatin on gene expression of LDLR, SREBPs, and SCD1 in rat hepatic tissues fed with high-fat diets (HFD) and its association with some biochemical parameters. Thirty-two male Wister albino rats were divided into four equal groups (three test and one control groups). The biochemical parameters were determined by using spectrophotometer techniques and the Elisa method. Read More

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http://dx.doi.org/10.1080/13813455.2020.1772829DOI Listing

Cross talk between exosomes and pancreatic β-cells in diabetes.

Arch Physiol Biochem 2020 Jul 8:1-10. Epub 2020 Jul 8.

Diabetes Research Center, Medical School, Ningbo University, Ningbo, China.

Exosomes are a class of extracellular vesicles with a diameter of 50-100 nm secreted by various cells. They are generated through complex intracellular production mechanisms before being secreted to the extracellular environment. Due to their inclusion of proteins, lipids, and nucleic acids, exosomes play an important role in intercellular communication. Read More

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http://dx.doi.org/10.1080/13813455.2020.1760303DOI Listing

Genetic polymorphisms -137 (G > C) (rs187238) and -607 (C > A) (rs1946518) and serum level of interleukin 18 in Fars ethnic groups with metabolic syndrome in Northern Iran.

Arch Physiol Biochem 2020 Jul 7:1-7. Epub 2020 Jul 7.

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

We aimed to determine the genetic polymorphisms and serum level of interleukin 18 in Fars ethnic groups. 226 Fars ethnic groups were participated. The ATP III criteria were used to assess MS components. Read More

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http://dx.doi.org/10.1080/13813455.2020.1784954DOI Listing

Bromhexine and its inhibitory effect on lipase - kinetics and structural study.

Arch Physiol Biochem 2020 Jul 7:1-6. Epub 2020 Jul 7.

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Lipase hydrolyses the ester bonds in triglyceride. It is an important enzyme in medicine and industry. Some pathogen bacteria use this exoenzyme to disrupt the extracellular matrix of host organisms. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788606DOI Listing

Pulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetes.

Arch Physiol Biochem 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

: The present study aimed to investigate the possible anti-neuropathic effects of daily pulsed magnetic field treatments (PMF) in streptozotocin (60 mg/kg) induced 4 weeks diabetic (type-1) wistar rats (6-8 months).: Body mass, blood glucose and thermal and mechanical sensations were evaluated during the PMF or sham-PMF in diabetic or non-diabetic rats (n = 7/group). After the measurements of motor nerve conduction velocities (MNCV), the levels of several biomarkers for oxidative stress, apoptosis and angiogenesis in spinal cord and sciatic nerve were measured. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788098DOI Listing

Circulating uncarboxylated matrix Gla protein in patients with atrial fibrillation or heart failure with preserved ejection fraction.

Arch Physiol Biochem 2020 Jul 3:1-11. Epub 2020 Jul 3.

Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical university of Varna, Varna, Bulgaria.

Circulating uncarboxylated matrix Gla protein (ucMGP) is possibly related to coronary arterial calcification (CAC) in cardiovascular disease (CVD) patients. We aimed to evaluate the relationships between circulating ucMGP, CVD pathology and CAC and its interplay with CVD risk factors. ucMGP was measured in 99 CVD-patients. Read More

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http://dx.doi.org/10.1080/13813455.2020.1786130DOI Listing

A comprehensive insight into the potential roles of VDR gene polymorphism in obesity: a systematic review.

Arch Physiol Biochem 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran.

Vitamin D receptor (VDR) gene polymorphisms are believed to be involved in the obesity pathogenesis. This study summarises the results of research concerning the association between VDR polymorphisms and obesity. For this survey, the records of common databases were searched until November 2019. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788097DOI Listing

Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against HO-induced oxidative stress.

Arch Physiol Biochem 2020 Jul 3:1-6. Epub 2020 Jul 3.

Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Recent surveys have shown an association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and oxidative stress. In this investigation, the effect of evolocumab an anti-PCSK9 antibody was assessed against oxidative damage caused by hydrogen peroxide (HO) in human umbilical vein endothelial cells (HUVEC). Viability of HUVEC was measured by MTT assay. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788605DOI Listing

Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model.

Arch Physiol Biochem 2020 Jul 2:1-8. Epub 2020 Jul 2.

Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

Our study aimed to illustrate the effect of the antihistaminic drug azelastine on aortic calcification in diabetic hyperlipidemic (DH) rats along with the underlying molecular mechanism. Twenty-four male albino Wistar rats were categorised into four groups. One group received normal rodent chow (normal group), while the other groups were rendered diabetic and hyperlipidemic; one received no drugs and served as a positive control while the other two groups received either azelastine (4 mg/kg) or 10-dehydrogingerdione (10 mg/kg) orally and daily for 8 weeks. Read More

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http://dx.doi.org/10.1080/13813455.2020.1786129DOI Listing

Up-regulation of miR-20a weakens inflammation and apoptosis in high-glucose-induced renal tubular cell mediating diabetic kidney disease by repressing CXCL8 expression.

Arch Physiol Biochem 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Geriatric Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China.

In our study, we determined the pattern of expression and biological roles of microRNA-20a (miR-20a) in diabetic kidney disease (DKD). The difference in the expression of miR-20a and proinflammatory genes (TNF-α, IL-6, and IL-1β) was measured across control, normal glucose (NG), and high glucose (HG) groups. Co-transfection miR-20a mimic and CXCL8 silence was used to assess the miR-20a/CXCL8 axis in the HG-induced HK-2 cell injury involved in DKD. Read More

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http://dx.doi.org/10.1080/13813455.2020.1785506DOI Listing

Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients.

Arch Physiol Biochem 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA. 100 RA patients and 100 healthy individuals were enrolled in the study. Read More

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http://dx.doi.org/10.1080/13813455.2020.1784951DOI Listing

Research progress of mechanisms for tight junction damage on blood-brain barrier inflammation.

Arch Physiol Biochem 2020 Jul 1:1-12. Epub 2020 Jul 1.

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.

Inflammation in the central nervous system (CNS) contributes to disease pathologies by disrupting the integrity of the blood-brain barrier (BBB). Tight junctions (TJ) are a key component of the BBB. Following hypoxic-ischaemic or mechanical injury to the brain, inflammatory mediators are released such as cytokines, chemokines, and growth factors. Read More

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http://dx.doi.org/10.1080/13813455.2020.1784952DOI Listing

Improvement of thiol groups and total antioxidant capacity in patients with non-alcoholic fatty liver after treatment with pioglitazone.

Arch Physiol Biochem 2020 Jul 1:1-5. Epub 2020 Jul 1.

Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

The aim of the present study was to evaluate oxidative stress state in non-alcoholic fatty liver (NAFLD) patients at the time of diagnosis and by passing three months from the treatment. 37 patients with NAFLD in summer 2019 were enrolled in this study. Also, 37 healthy controls that were matched for sex and age were included as a control group. Read More

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http://dx.doi.org/10.1080/13813455.2020.1784953DOI Listing

The interrelationship between inflammatory cytokines and skeletal muscle decay from the viewpoint of circadian rhythms.

Arch Physiol Biochem 2020 Jul 1:1-7. Epub 2020 Jul 1.

Department of Histology and Embryology, Shanxi Medical University, Taiyuan, PR China.

Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. Read More

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http://dx.doi.org/10.1080/13813455.2020.1782435DOI Listing

The effect of evening primrose oil () on the level of adiponectin and some biochemical parameters in rats with fructose induced metabolic syndrome.

Arch Physiol Biochem 2020 Jun 27:1-9. Epub 2020 Jun 27.

Faculty of Veterinary Medicine, Department of Biochemistry, Van Yuzuncu Yil University, Van, Turkey.

The effect of evening primrose oil on adiponectin level and some biochemical parameters in model of fructose-induced metabolic syndrome were investigated. The rats were divided into 4 groups: control, evening primrose oil, fructose, fructose + evening primrose oil. Body weight, daily feed and water consumptions and systolic blood pressures of animals were measured. Read More

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http://dx.doi.org/10.1080/13813455.2020.1781900DOI Listing

Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats.

Arch Physiol Biochem 2020 Jun 25:1-9. Epub 2020 Jun 25.

Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan Nigeria.

The inhibition of renin angiotensin system pathway has been largely documented to be effective in the control of cardiovascular events. The present study investigated the effect of angiotensin converting enzyme (ACE) inhibitor on fasting blood glucose level in hypertension induced by the inhibition of nitric oxide synthase (NOS) in male Wistar rats. Hypertension was induced by the inhibition of NOS using a non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). Read More

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http://dx.doi.org/10.1080/13813455.2020.1780263DOI Listing

Hypolipemic effects of histamine is due to inhibition of VLDL secretion from the liver: involvement of both H1 and H2-receptors.

Arch Physiol Biochem 2020 Jun 24:1-5. Epub 2020 Jun 24.

Faculty of Medicine, Department of Clinical Biochemistry and Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

The research was performed to study the mechanism whereby histamine affects the profile of plasma lipids. Six groups of ten male rats were received two injections with histamine or its H1- and H2-agonists and antagonists. Histamine caused a significant decrease in the concentrations of triglyceride, total cholesterol, and LDLc, while HDLc had no significant change. Read More

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http://dx.doi.org/10.1080/13813455.2020.1782436DOI Listing

Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis.

Arch Physiol Biochem 2020 Jun 23:1-5. Epub 2020 Jun 23.

Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773861DOI Listing

Effect of on TGF-β1 and vascular mediators in a rat model of diabetic nephropathy.

Arch Physiol Biochem 2020 Jun 23:1-11. Epub 2020 Jun 23.

Medical Physiology Department, College of Medicine, Khartoum University, Khartoum, Sudan.

Transforming growth factor-β1 (TGF-β1), endothelin-1 and angiotensin II are responsible for extracellular matrix accumulation within the kidney in diabetic nephropathy. This study evaluated the effect of adding Gum Arabic (GA) and insulin on serum glucose, renal function, TGF-β1, endothelin-1, and angiotensin II in rats with diabetic nephropathy. Sixty male Sprague-Dawley rats were divided into; normal, normal plus GA, diabetic rats (DM), DM plus insulin, DM plus GA, and DM plus insulin plus GA groups. Read More

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http://dx.doi.org/10.1080/13813455.2020.1781901DOI Listing

The effect of nutrition and exercise training on irisin and semaphorin-3E levels in obese patients.

Arch Physiol Biochem 2020 Jun 22:1-10. Epub 2020 Jun 22.

Department of Medical Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individuals. Nutrition and exercise training were applied to groups for eight weeks. Read More

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http://dx.doi.org/10.1080/13813455.2020.1779310DOI Listing

Decreased level of plasma nesfatin-1 in rats exposed to cell phone radiation is correlated with thyroid dysfunction, oxidative stress, and apoptosis.

Arch Physiol Biochem 2020 Jun 17:1-7. Epub 2020 Jun 17.

Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt.

Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland. To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF. Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. Read More

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http://dx.doi.org/10.1080/13813455.2020.1778037DOI Listing

What the discovery of irisin receptor means to bone.

Arch Physiol Biochem 2020 Jun 17:1-3. Epub 2020 Jun 17.

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, PR China.

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http://dx.doi.org/10.1080/13813455.2020.1772310DOI Listing

LncRNA AWPPH is downregulated in osteoporosis and regulates type I collagen α1 and α2 ratio.

Arch Physiol Biochem 2020 Jun 17:1-5. Epub 2020 Jun 17.

Department of Orthopedics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, P. R. China.

Normal ratio of type I collagen α1 to α2 (2:1) maintains normal bone microarchitecture. Altered ratios lead to formation of collagen homotrimers and deteriorated bone microarchitecture. In this study, we aimed to investigate the role of lncRNA AWPPH in osteoporosis. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767150DOI Listing

Aberrant methylation of miR-124 upregulates DNMT3B in colorectal cancer to accelerate invasion and migration.

Arch Physiol Biochem 2020 Jun 18:1-7. Epub 2020 Jun 18.

Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The dysregulation of microRNA expression is significantly associated with the initiation and development of CRC. miR-124 is markedly downregulated in colorectal cancer. In the present study, the effects of methylation, over expression and downregulation of miR-124 and its target gene DNMT3B on the proliferation, migration and invasion of colorectal cell line were investigated. Read More

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http://dx.doi.org/10.1080/13813455.2020.1779311DOI Listing

MiRNA-6089 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting CCR4.

Arch Physiol Biochem 2020 Jun 17:1-8. Epub 2020 Jun 17.

Department of Nephrology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, China.

Several studies have suggested that fibroblast-like synoviocytes (FLSs) and miRNAs are implicated in the pathogenesis of rheumatoid arthritis (RA). This study was aimed to evaluate the function of miR-6089 in the regulation of RA-FLSs. The levels of miR-6089 were detected to be significantly lower in the synovial tissues and FLSs of RA than in the healthy synovial tissues and FLSs. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773862DOI Listing

Effect of chemokine CXCL14 on angiogenesis of human hepatocellular carcinoma cells.

Arch Physiol Biochem 2020 Jun 17:1-7. Epub 2020 Jun 17.

Department of Hepatobiliary, Pancreatic and Gastric Surgery, Jinhua Guangfu Hospital, Jinhua, China.

The study was designed to investigate the effect of chemokine CXCL14 on angiogenesis of human hepatocellular carcinoma (HCC) cells. CXCL14 mRNA expression in HCC tissue samples and adjacent tissue samples was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). CXCL14 mRNA and protein expression in human normal hepatocyte HL-7702 and HCC cell line HepG2 were detected by qRT-PCR and western blot. Read More

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http://dx.doi.org/10.1080/13813455.2020.1769677DOI Listing

LncRNA GAS5 upregulates miR-214 through methylation to participate in cell apoptosis of sepsis.

Arch Physiol Biochem 2020 Jun 19:1-6. Epub 2020 Jun 19.

Department of Nursing, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

It has been reported that lncRNA GAS5 can inhibit LPS-induced inflammation, indicating its involvement in sepsis. We observed the downregulation of GAS5 in plasma of sepsis patients. In addition, expression levels of GAS5 were positively correlated with the expression levels of miR-214. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764051DOI Listing

Cardioprotective doses of thyroid hormones improve NO bioavailability in erythrocytes and increase HIF-1α expression in the heart of infarcted rats.

Arch Physiol Biochem 2020 Jun 17:1-8. Epub 2020 Jun 17.

Laboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Infarction leads to a decrease in NO bioavailability in the erythrocytes. Thyroid hormones (TH) present positive effects after infarction. However, there are no studies evaluating the effects of cardioprotective doses of TH in the erythrocytes after infarction. Read More

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http://dx.doi.org/10.1080/13813455.2020.1779752DOI Listing

Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children.

Arch Physiol Biochem 2020 Jun 18:1-6. Epub 2020 Jun 18.

Research Centre for Anthropology and Health (CIAS), Department of Life Sciences, University of Coimbra, Coimbra, Portugal.

To investigate the association of polymorphisms in and genes with obesity indices in children. A total of 637 Portuguese children (317 girls; 320 boys) aged 3-11 years-old were genotyped for the polymorphisms, 5-HTTLPR and STin2, and for a VNTR. Polymorphisms were analysed by PCR-based methods. Read More

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http://dx.doi.org/10.1080/13813455.2020.1779312DOI Listing

Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus upregulation of SIRT1 in a sepsis model.

Arch Physiol Biochem 2020 Jun 13:1-8. Epub 2020 Jun 13.

Department of Anesthesiology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Septic encephalopathy (SE) is a devastating consequence of sepsis, a hyper-triggered host response against infectious challenge, which ultimately leads to brain damage. The present study examined whether sevoflurane (SVF), a volatile anaesthetic, can counteract the perturbation of homeostasis in a caecal ligation and puncture (CLP)-induced mouse model of SE. SVF enhances neurocognition in terms of spatial memory improvement counter-regulation of activated oxidative-inflammatory stress and pyroptotic processes in SE. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773860DOI Listing

Carnitine, apelin and resveratrol regulate mitochondrial quality control (QC) related proteins and ameliorate acute kidney injury: role of hydrogen peroxide.

Arch Physiol Biochem 2020 Jun 13:1-10. Epub 2020 Jun 13.

Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Mitochondrial impairment is recognised as a prominent feature in kidney diseases. Therefore, we investigated whether the effects of resveratrol, L-carnitine, and apelin in the acute kidney injury model were associated with modulation of mitochondrial quality control (QC) related proteins, intra-renal renin-angiotensin (RAS) activity, adenosine triphosphate (ATP) and Na-K ATPase gene expression. Rats were randomly assigned to 7 groups: Distilled water injected control group, DMSO injected control group, distilled water injected lipopolysaccharide (LPS) group, DMSO injected LPS group, resveratrol injected LPS group, L-carnitine injected LPS group and apelin 13 injected LPS group. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773504DOI Listing

Anti-obesity, anti-hyperglycaemic, anti-antipyretic and analgesic activities of extracts.

Arch Physiol Biochem 2020 Jun 13:1-8. Epub 2020 Jun 13.

Laboratory of Bioresources: Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.

The aim of this study is to evaluate the anti-obesity, anti-hyperglycaemic, analgesic and antipyretic activities of (GA). GA methanol and water extracts (GAME, GAWE) were administered to high-fat-high-glucose diet (HFFD) rats. This study showed that GAME exhibited the highest antioxidant, anti-α-amylase and anti-lipase activities, with half inhibitory concentration (IC50) values 0. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773865DOI Listing

Hyperglycaemia and the risk of post-surgical adhesion.

Arch Physiol Biochem 2020 Jun 13:1-7. Epub 2020 Jun 13.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Post-surgical adhesions are a major complication leading to organ dysfunctions, pain, intestinal obstruction, and infertility. The incidence of post-surgical adhesion is really high. The factors involved in the pathogenesis of post-surgical fibrosis, are largely unknown, for example why two patients with similar abdominal operation have a different risks of adhesion severity? High secretion of pro-inflammatory cytokines and growth factors, includes tumour necrosis factor α (TNF-α), interleukin 6 (IL6), and transforming growth factor β (TGF-β) by persistent recruitment of immune cells and the inappropriate proliferated fibroblast/mesothelial cells can stimulate signalling pathways particularly TGF-β leads to the up-regulation of some pro-fibrotic genes that impair fibrinolytic activity and promote extracellular matrix (ECM) accumulation. Read More

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http://dx.doi.org/10.1080/13813455.2020.1776330DOI Listing

Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.

Arch Physiol Biochem 2020 Jun 13:1-6. Epub 2020 Jun 13.

Physiologie de la Nutrition & Toxicologie, UMR 1231 INSERM/Université de Bourgogne/Agro-Sup, Dijon, France.

The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. Read More

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http://dx.doi.org/10.1080/13813455.2020.1775655DOI Listing

Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review.

Arch Physiol Biochem 2020 Jun 10:1-15. Epub 2020 Jun 10.

Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Chemotherapy has opened a new window in cancer therapy. However, the resistance of cancer cells has dramatically reduced the efficacy of chemotherapy. Cisplatin is a chemotherapeutic agent and its potential in cancer therapy has been restricted by resistance of cancer cells. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773864DOI Listing

The evaluation of early stage oxidative status in streptozotocin induced diabetes in rats.

Arch Physiol Biochem 2020 Jun 10:1-5. Epub 2020 Jun 10.

Department of Biochemistry, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.

Early-stage diabetes can be defined as the stages before absolute insulin deficiency in patients. In this study, the early stage oxidative effect of streptozotocin(STZ) induced diabetes mellitus was evaluated. 28 male adult Sprague-Dawley rats were divided into four groups; control group and 7th, 14th, 21st days diabetic groups. Read More

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http://dx.doi.org/10.1080/13813455.2020.1776736DOI Listing

Association between maternal serum uric acid and preeclampsia.

Arch Physiol Biochem 2020 Jun 10:1-4. Epub 2020 Jun 10.

Department of Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran.

The aim of this study is to compare the changes in serum uric acid levels among preeclamptic pregnant women and healthy pregnant women. Two hundred and twenty-four (224) pregnant women were enrolled. Serum uric acid levels were analysed in the two groups at the time of referral and prior to the delivery. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773863DOI Listing

Physiological and pharmacological perspectives of melatonin.

Authors:
Saptadip Samanta

Arch Physiol Biochem 2020 Jun 10:1-22. Epub 2020 Jun 10.

Department Physiology, Midnapore College, Midnapore, India.

The pineal gland is a interface between light-dark cycle and shows neuro-endocrine functions. Melatonin is the primary hormone of pineal gland, secreted at night. The night-time melatonin peak regulates the physiological functions at dark. Read More

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http://dx.doi.org/10.1080/13813455.2020.1770799DOI Listing

Melatonin attenuates diabetes-induced oxidative stress in spleen and suppression of splenocyte proliferation in laboratory mice.

Arch Physiol Biochem 2020 Jun 5:1-12. Epub 2020 Jun 5.

Molecular Endocrine Research Lab, Department of Zoology, Tripura University, Tripura, India.

Hyperglycaemic condition induced oxidative stress in diabetic individuals caused oxidative damages of internal organs, including immune organ spleen. We studied the effects of low doses of melatonin (25, 50, and 100 µg/100g. B. Read More

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http://dx.doi.org/10.1080/13813455.2020.1773506DOI Listing

LncRNA AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells.

Arch Physiol Biochem 2020 Jun 5:1-6. Epub 2020 Jun 5.

Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

This study aimed to investigate the role of lncRNA AK131850 in thoracic aortic aneurysm (TAA). We found that AK131850 was downregulated, while TGF-β1 was upregulated in aortic media specimen of thoracic aortic aneurysm (TAA) patients. In addition, AK131850 and TGF-β1 inversely correlated. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767653DOI Listing

Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress.

Arch Physiol Biochem 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers. T2DM was induced by streptozotocin (50 mg/kg body weight) and high carbohydrate and fat diet (HCFD). The protective group was put on resveratrol (30 mg/kg) 14 days prior to the induction of diabetes and continued on resveratrol and HCFD until being sacrificed at week 12. Read More

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http://dx.doi.org/10.1080/13813455.2020.1771378DOI Listing

Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure.

Arch Physiol Biochem 2020 Jun 4:1-6. Epub 2020 Jun 4.

Department of Emergency Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey.

We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups ( < . Read More

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http://dx.doi.org/10.1080/13813455.2020.1773505DOI Listing

A pinitol-rich L. leaf extract as functional supplement with potential in the prevention of endothelial dysfunction through improving insulin signalling.

Arch Physiol Biochem 2020 Jun 1:1-10. Epub 2020 Jun 1.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Messina, Italy.

L. is one of the most popular medicinal plant in the world, its roots having been used since ancient times in many traditional medicines. On the contrary, scarce attention has been dedicated to liquorice aerial parts. Read More

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http://dx.doi.org/10.1080/13813455.2020.1764046DOI Listing

Effect of folic acid and vitamin E on promoter DNA methylation and expression of TGF-β1, ESR-1 and CDH-1 in the uterus of STZ-induced diabetic rats.

Arch Physiol Biochem 2020 May 29:1-7. Epub 2020 May 29.

Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

The present study is the first attempt made to investigate the effects of diabetes on expression and promoter DNA methylation of TGF-β1, ESR-1, and CDH-1 genes and also the effects of folic acid (FA) and vitamin E (Vit E) supplementations on improving diabetes mellitus. STZ-induced diabetic rats were treated with Vit E (200 mg/kg/day) and FA (25 mg/kg/day) for 8 weeks and expression and DNA methylation of TGF-β1, ESR-1, and CDH-1 genes in uterus were analysed. Data indicated that diabetes increases the expression of TGFβ-1 and ESR-1 and decreases CDH-1 expression and TGFβ-1 promoter methylation in the uterus of rats. Read More

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http://dx.doi.org/10.1080/13813455.2020.1770798DOI Listing

Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: and study.

Arch Physiol Biochem 2020 May 28:1-7. Epub 2020 May 28.

Nutrition and Dietetics Department, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey.

Aldose reductase (AR) is the first enzyme of the polyol pathway that has physiological importance under hyperglycaemic conditions. The article has been focussed on AR enzyme inhibition by selected compounds. For this purpose, the inhibitory effects of various compounds on commercially available recombinant human AR (rAR) enzyme activity were investigated. Read More

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http://dx.doi.org/10.1080/13813455.2020.1771377DOI Listing

Exercise training decreases oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension.

Arch Physiol Biochem 2020 May 25:1-9. Epub 2020 May 25.

Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session, at 60% of VO max. Read More

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http://dx.doi.org/10.1080/13813455.2020.1769679DOI Listing

MicroRNA-143 inhibits proliferation and migration of prostate cancer cells.

Arch Physiol Biochem 2020 May 25:1-7. Epub 2020 May 25.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Prostate cancer (PC) is one of the most prevalent types of malignancies in males. Here, we replaced the miRNA-143 in PC cells by using a vector-based miRNA-143 transfection approach. The miRNA-143 vector was transfected into the cells and qRT-PCR was applied to assess the expression of target genes in PC3 cells. Read More

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http://dx.doi.org/10.1080/13813455.2020.1769678DOI Listing

The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF.

Arch Physiol Biochem 2020 May 25:1-10. Epub 2020 May 25.

Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang, China.

Gene expression microarray and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure the expression of miR-126. In model of diabetic nephropathy, we demonstrated that miR-126 expression was down-regulated, compared with control group. Down-expression of miR-126 promoted cell apoptosis and increased inflammation (as indicated by the levels of IL-1β, IL-6, IL-18 and TNF-α) of diabetic nephropathy . Read More

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http://dx.doi.org/10.1080/13813455.2020.1767146DOI Listing

Identification of amyloid antibodies for Alzheimer disease - immunotherapy.

Arch Physiol Biochem 2020 May 25:1-8. Epub 2020 May 25.

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

The current study identified the specific antibodies that recognise amyloid protein for Alzheimer disease - immunotherapy. The immune-selection of random sequences from a phage display library and sequencing to obtain the random 12 amino acids peptide library for each antibody, and then we analysed these peptides for unique and common sequences, relation to Aβ42 sequence and shape and pattern of the amino acid reaction to the antibody to predict the epitopes. Data obtained for 4G8 showed that, the sequence segment related to the putative epitope of 4G8 was LVFFAED. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767147DOI Listing