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Arch Oral Biol 2022 May 13;140:105454. Epub 2022 May 13.

Department of Oral & Maxillofacial Surgery, College and Hospital of Stomatology, Hebei Medical University, The Key Laboratory of Stomatology, Hebei Province, China.

Objective: This article aims to systematically and comprehensively discuss molecular biology-related progress and targeted therapeutic strategies for ameloblastoma, which are expected to be helpful for the diagnosis and treatment of ameloblastoma.

Design: A comprehensive review of scientific literature relevant to ameloblastoma, including the latest classification, global epidemiology, molecular biology advances, and targeted therapy.

Results: Among the 156 articles cited, a total of 20 non-coding RNAs, 13 genes, 27 proteins, and 8 pathways were involved, which play a variety of roles in ameloblastoma. Read More

Arch Oral Biol 2022 May 13;140:105452. Epub 2022 May 13.

Laboratory Centre for Anthropology and Genomics of Toulouse, Université Paul Sabatier, Toulouse, France; Service de Médecine Légale, Hôpital de Rangueil, Toulouse, France.

Objective: This work describes and compares the root and root canal morphology of a medieval population dating from the 8th to 10th century from the southwest of France, and a current French population.

Design: The root morphology of 579 teeth from 70 medieval individuals was analyzed using cone beam computed tomography, and compared with 690 teeth from a current French population of 329 individuals. The Vertucci classification was used to describe the root canal configuration. Read More

Arch Oral Biol 2022 May 16;140:105449. Epub 2022 May 16.

Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa (Italy), Via Roma 57, 56126 Pisa, Italy.

Objective: This study aims to investigate the following aspects: i) presence of activity-induced dental modifications (AIDMs) in a medieval population from Pieve di Pava (Siena, central Italy); ii) sex-specific and age-specific distribution of AIDMs in the sample; iii) potential correlations between AIDMs and the tradi tional activities and cultural habits of rural communities in medieval Italy.

Design: The permanent teeth of 204 individuals buried at Pieve di Pava (10th-12th centuries AD) were systematically examined in order to assess the distribution of five types of AIDM, i.e. Read More

Arch Oral Biol 2022 May 12;140:105453. Epub 2022 May 12.

Unidad de Investigación Básica Oral (UIBO), Vicerrectoría de investigaciones, Facultad de Odontología, Universidad El Bosque, Bogotá, Colombia. Electronic address:

Objective: The aim was to determine the changes of inflammatory mediator expression in human macrophages stimulated with outer membrane vesicles purified from Porphyromonas gingivalis.

Design: outer membrane vesicles purified by ultracentrifugation from ATCC 33277 and W83 P. gingivalis strains were used for stimulating human macrophages and determine their inflammatory mediator expression changes. Read More

Arch Oral Biol 2022 Apr 29;140:105448. Epub 2022 Apr 29.

Reconstructive Sciences Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Objective: This study aims to explore and compare the histopathology of upper cleft lip tissue in order to identify the abnormalities and orientation of muscle and collagen fibers in patients affected with non-syndromic cleft lip with or without cleft palate (NSCL±P) and normal controls.

Materials And Methods: Eight fresh lip tissues of consented patients with NSCL±P and two controls were fixed and stained with hematoxylin and eosin (H&E), Masson's trichrome (MT), and modified Gomori trichrome techniques. The images were captured and examined using imaging cellSens software (Olympus, Tokyo, Japan) and Mirax Scan (Carl Zeiss, Germany). Read More

Arch Oral Biol 2022 Jul 18;139:105433. Epub 2022 Apr 18.

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objective: This study aimed to determine the effect of C-type natriuretic peptide (CNP) overexpression on craniofacial growth during the pubertal growth period in mice.

Design: Six-week-old C57BL/6 mice were injected with pLIVE-Empty vectors (Control mice) and pLIVE-NPPC vectors (CNP mice) using the hydrodynamic method. Morphological analyses were performed at the age of 12 weeks. Read More

Arch Oral Biol 2022 Jul 3;139:105450. Epub 2022 May 3.

Karadeniz Technical University, Faculty Of Dentistry, Department of Pediatric Dentistry, Turkey. Electronic address:

Objective: This case-control study aimed to evaluate dental age estimation in children with hypothyroidism using two different methods in order to contribute to the literature about the most accurate method.

Design: In the study, panoramic radiographs of 80 patients with hypothyroidism aged 5-13 years and 80 randomly selected age and sex-matched healthy patients were examined retrospectively. The Cameriere's and the Nolla's methods were used for the dental age estimation. Read More

Arch Oral Biol 2022 Jul 18;139:105434. Epub 2022 Apr 18.

Department of Restorative Dentistry, Rutgers School of Dental Medicine, NJ, USA.

Objective: This study was performed to evaluate the effect of type 1 diabetes mellitus (T1DM) on the microhardness of tooth enamel and dentine in mice.

Design: Seventy male C57BL/6 J mice were used in this study. Thirty-five mice were rendered diabetic by administration of streptozotocin (STZ), and the remaining animals received citrate buffer (normal/non-diabetic). Read More

Arch Oral Biol 2022 Jul 26;139:105446. Epub 2022 Apr 26.

State Key Laboratory of Oral Diseases and National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu, China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objective: Streptococcus mutans is a key pathogen involved in the development of caries lesions. Previously, we developed a novel lactotransferrin-derived antimicrobial peptide LF-1 with potential selective activity against S. mutans. Read More

Arch Oral Biol 2022 Jul 27;139:105447. Epub 2022 Apr 27.

Beijing Stomatological Hospital, Capital Medical University, Tiantanxili No 4#, Dongcheng District, Beijing 100050, China. Electronic address:

Objective: To determine whether the breast cancer susceptibility gene 1 (BRCA1) regulates oxidative damage in oral cancer cells by interacting with nuclear factor erythroid 2-like 2 (NRF2).

Design: The BRCA1 gene was silenced in CAL-27 and DOK cells using specific shRNA, and NRF2 was activated with sulforaphane. The expression levels of BRCA1, NRF2 and its target genes were assessed by quantitative real-time polymerase chain reaction and western blotting. Read More

Arch Oral Biol 2022 Jul 18;139:105435. Epub 2022 Apr 18.

Department of Community Dentistry, School of Dentistry, Araraquara, São Paulo State University, Unesp, Brazil, Rua Humaitá 1680, Araraquara, SP 14.801-903, Brazil. Electronic address:

Objective: To perform three-dimensional measurements (volume and area) of the maxillary sinus, from cone-beam computed tomography (CBCT) images, and to assess potential differences between the left and right sides and a correlation of the measurements to sex, age, skin color, and nutritional status.

Design: CBCT images of 161 living Brazilian subjects of both sexes (89 women and 72 men) were used, and three-dimensional measurements of volume and area were made with the beta version of the DDS-Pro™ 2.14. Read More

Arch Oral Biol 2022 Jul 13;139:105432. Epub 2022 Apr 13.

Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil. Electronic address:

Objective: To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children.

Methods: Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. Read More

Arch Oral Biol 2022 Jul 7;139:105429. Epub 2022 Apr 7.

Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil; Endoscopy Department, Endopasso, Passo Fundo, Brazil.

Objectives: To identify the bile acids in the saliva of patients with and without gastroesophageal reflux disease (GERD), and evaluate their effect on tooth surface.

Design: A cross-sectional study involved 26 GERD patients and 40 controls without GERD. Dental erosions were identified, saliva was collected and analyzed with chromatography for bile acid identification. Read More

Arch Oral Biol 2022 Jul 6;139:105428. Epub 2022 Apr 6.

Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India; DHR-MRU, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India. Electronic address:

Objective: The objective of this study is to identify the association between linc-ROR genetic variants and oral squamous cell carcinoma tumorigenesis.

Design: Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1942348, and rs9636089) were analyzed in 178 OSCCs and 191 controls of the South Indian population by PCR amplification followed by restriction digestion. In addition, we examined whether these variants alter linc-ROR expression levels and the progression of OSCC. Read More

Arch Oral Biol 2022 Jul 14;139:105430. Epub 2022 Apr 14.

Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö, Sweden; Scandinavian Center for Orofacial Neurosciences (SCON), Malmö, Sweden; Specialized Pain Rehabilitation, Skåne University Hospital, Lund, Sweden.

Objective: The aim of the present systematic review was to assess the effect of testosterone on temporomandibular joint (TMJ) nociception.

Design: A systematic review of pertinent indexed literature was performed. The focused question addressed was "Is there a connection between testosterone and TMJ nociception?" Original studies were included. Read More

Arch Oral Biol 2022 Jul 13;139:105431. Epub 2022 Apr 13.

Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran.

Objective: This study evaluated the frequency and the effects of S. mutans and S. sobrinus on Decayed, Missing, and Filled Teeth (DMFT) scores in Iranian and Afghan populations. Read More

Arch Oral Biol 2022 Jul 21;139:105391. Epub 2022 Mar 21.

The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University), No. 137 South Liyushan Road, Urumqi 830054, People's Republic of China; Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region, No.137 South Liyushan Road, Urumqi 830054, People's Republic of China. Electronic address:

Objectives: To investigate the main active components, potential targets of action and analyze the potential molecular mechanisms of Mori Folium in preventing and treating periodontitis using network pharmacology and molecular docking methods.

Materials And Methods: The main components and action targets of Mori Folium were obtained in TCMSP and ETCM databases, and then the action targets of Mori Folium components were inversing screening using Swiss Target Prediction and BATMAN-TCM databases. Targets associated with periodontitis were retrieved from OMIM, Genecard, DrugBank, NCBI Gene and DisGeNET databases. Read More

Arch Oral Biol 2022 Jul 14;139:105426. Epub 2022 Apr 14.

Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Champaign, IL 61801, USA.

Objective: Vibrations applied to human teeth have been shown to induce vibrotactile sensations although the location of the mechanoreceptors responsible for encoding vibrations is unclear. The aim of this study is to test the hypothesis that vibrotactile tooth sensations depend on afferent input from intradental mechanoreceptors.

Design: Vibration perception thresholds were determined for a vital (control) and a contralateral nonvital (endodontically treated) maxillary incisor in 11 healthy human participants using an adaptive psychophysical procedure. Read More

Arch Oral Biol 2022 Jun 6;138:105427. Epub 2022 Apr 6.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objective: To investigate whether and how global O-linked N-Acetylglucosamine modification (O-GlcNAcylation), a prevalent nutrient-sensitive post-translation modification, regulates odontogenic differentiation and mineralization in human dental pulp cells (hDPCs).

Design: First, immunostaining assays on sections of dental pulp tissue were performed to detect the distributions of O-GlcNAcylation and its exclusive enzyme set O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Then global O-GlcNAcylation was determined by anti O-linked N-Acetylglucosamine (RL2) Western blot during odontogenesis of hDPCs. Read More

Arch Oral Biol 2022 Jun 24;138:105415. Epub 2022 Mar 24.

Faculty of Dentistry, Thammasat University, Pathum Thani, Thailand.

Objective: As the emerging resistance of Candida species to common antifungals is a major global concern, we assessed the antifungal susceptibility of oral yeast isolates from a healthy, Thai adult cohort, and correlated the yeast prevalence with oral disease indices.

Methods: Oral rinse samples collected from 100 Thai adults were concentrated and cultured on CHROMagar Candida. The yeasts were then isolated, identified and finally speciated using Matrix Assisted Laser Desorption ionization-time of flight mass spectrometry. Read More

Arch Oral Biol 2022 Jun 6;138:105346. Epub 2022 Jan 6.

Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, PR China. Electronic address:

Objectives: The aim of the present study was to explore expression profiles of circular RNAs (circRNAs) and potential molecular mechanisms in oral squamous cell carcinoma (OSCC).

Design: In this study, high-throughput microarray was used to detect the expression profiles of circRNAs in OSCC. Reverse transcription quantitative PCR (RT-qPCR) was used to quantify the expression of dysregulated circRNAs in microarray. Read More

Arch Oral Biol 2022 Jun 22;138:105413. Epub 2022 Mar 22.

Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Objective: Considering the variety of pharmacological activities and the potential to mediate biomineralization, the flavonoids taxifolin and epigallocatechin-3-gallate (EGCG) could be explored as biomolecules in scaffolds for regenerative endodontic procedures. The aim of this study was to evaluate the effect of taxifolin and EGCG on the cell viability, differentiation, and expression of biomineralization markers in stem cells from the apical papilla.

Design: Stem cells from the apical papilla were exposed to single or continuous treatments with taxifolin at 200, 100 and 50 µM and EGCG at 50, 25 and 12. Read More

Arch Oral Biol 2022 Jun 25;138:105412. Epub 2022 Mar 25.

Department of Stomatology, Affiliated Hospital of Beihua University, Jilin 132011, Jilin, PR China. Electronic address:

Objective: Nuclear receptor-binding SET domain protein 2 (NSD2) belongs to the SET histone methyltransferase family with potential oncogenic roles. This study aimed to probe the roles of NSD2 and its relevant molecules in oral squamous cell carcinoma (OSCC).

Methods: An OSCC-related GSE138206 dataset was analyzed to identify potential key genes implicated in OSCC development. Read More

Arch Oral Biol 2022 Jun 25;138:105425. Epub 2022 Mar 25.

Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil. Electronic address:

Objective: The present study aimed to conduct a systematic review of the literature, to evaluate, in vitro, the effectiveness of the technique of photodynamic therapy against microorganisms associated with periodontal disease.

Design: This systematic review was carried out in accordance with the items on the PRISMA checklist and Cochrane guidelines. Only in vitro studies that evaluated the effect of the technique of antimicrobial photodynamic therapy on periodontopathogenic microorganisms were included. Read More

Arch Oral Biol 2022 Jun 24;138:105414. Epub 2022 Mar 24.

Department of Orthodontics II, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address:

Objective: In this study, we aimed to explore the mechanism underlying microRNA-20a (miR-20a) in viability, migration and osteogenic/odontoblastic differentiation of dental pulp stem cells (DPSCs).

Design: The results of Targetscan unveiled that interleukin (IL)- 8 might bind to miR-20a, which was confirmed by dual-luciferase reporter assay. MiR-20a expression was up-regulated or down-regulated in DPSCs, followed by measurement of cell viability and migration via MTT and wound healing assays. Read More

Arch Oral Biol 2022 Jun 16;138:105411. Epub 2022 Mar 16.

Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, China; College of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Nanning 530021, China.

Objective: The aim of this study was to evaluate the effects of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs-Exo) and human dental pulp stem cells (hDPSCs-Exo) on lipopolysaccharide-induced inflammation in human dental pulp stem cells.

Methods: Exosomes were extracted from the supernatant of human umbilical cord mesenchymal stem cells and human dental pulp stem cells. Lipopolysaccharide was used to establish the inflammation model in human dental pulp stem cells. Read More

Arch Oral Biol 2022 Jun 16;138:105409. Epub 2022 Mar 16.

Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. Electronic address:

Objective: The aim of this study was to investigate the mechanisms of how protein kinase A (PKA) is activated during bone morphogenetic protein 2 (BMP2)-induced osteogenic differentiation in dental follicle stem cells.

Design: Human dental follicle stem cells were cultured and treated with a BMP2-containing osteogenic differentiation medium or differentiation medium without BMP2. Specific siRNAs and substances/proteins were used to modulate pathways. Read More

Arch Oral Biol 2022 May 17;137:105398. Epub 2022 Mar 17.

Faculty of Dentistry, McGill University, Montreal, QC, Canada. Electronic address:

Arch Oral Biol 2022 Jun 15;138:105410. Epub 2022 Mar 15.

Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

Objectives: The purpose of the present study was to examine the influence of hyperbaric oxygen (HBO) on the function of osteoblastic MC3T3-E1 cells.

Design: Murine MC3T3-E1 cells were exposed to HBO treatment (at 2.5 absolute atmospheric pressure with 100% oxygen, 90 min per day) for 28 days. Read More

Arch Oral Biol 2022 May 14;137:105395. Epub 2022 Mar 14.

Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Objectives: Genomic instability in cancers is often associated with poor disease outcomes. In Head and Neck Squamous Cell Carcinoma (HNSCC), saliva being the contact fluid contains cancers cells shed from the primary tumour. This study detected genomic instability from cancer cells shed in saliva and correlated the same with clinical implications. Read More