3,299 results match your criteria Archives Of Medical Research[Journal]


Erratum to "Multiple Sclerosis-associated Bacterial Ligand 654" [Archives of Medical Research 53/2(February 2022) 157-162/ARCMED_2021_2713].

Arch Med Res 2022 May 20. Epub 2022 May 20.

Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA. Electronic address:

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Effect of Anti-Podoplanin on Malignant Glioma Cell Viability, Invasion and Tumor Cell-Induced Platelet Aggregation.

Arch Med Res 2022 May 19. Epub 2022 May 19.

Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan, Iran. Electronic address:

Background: The transmembrane receptor podoplanin (PDPN) is a platelet aggregation-inducing factor, which is widely expressed in various malignant tumors such as squamous cell carcinomas, mesotheliomas, glioblastomas. Podoplanin regulates a pathway leading to cell invasion and migration. Glioblastoma multiforme (GBM) is the most aggressive and invasive tumor of the central nervous system. Read More

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Regarding the Article: A multimodal strategy to reduce the risk of hospitalization/death in ambulatory patients with COVID-19.

Arch Med Res 2022 May 17. Epub 2022 May 17.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address:

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Detection Of TLR-2 germ line variants as a risk for obesity in local Pakistani population.

Arch Med Res 2022 May 12. Epub 2022 May 12.

Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

Background: Obesity is increasing rapidly affecting half billion adult's population. Pathophysiology of obesity involves low grade inflammation sustained by Toll like receptor 2 (TLR-2) the innate immune adapters. This study was conducted for detection and association of TLR-2 gene mutations with obesity. Read More

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Increment of D-dimer Associated with Immune Thrombotic Thrombocytopenia in ChAdOx1 nCoV-19 (AstraZeneca-Oxford) Vaccinated Individuals: A Systematic Review.

Arch Med Res 2022 May 6. Epub 2022 May 6.

Médico de Medicina Familiar, Instituto Mexicano del Seguro Social, Los Mochis, Sinaloa, Mexico.

Aim Of The Study: Development of thrombocytopenia and thrombosis after administration of the ChAdox1 nCoV-19 (AstraZeneca-Oxford) vaccine has recently been described. This new condition is called vaccine-induced immune thrombotic thrombocytopenia (VITT). Our objective was to summarize case reports on VITT with/without D-dimer increments in AstraZeneca-Oxford vaccinated individuals. Read More

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Challenges for Peritoneal Dialysis Centers Before and During the COVID-19 Pandemic in Mexico.

Arch Med Res 2022 Apr 29. Epub 2022 Apr 29.

Unidad de Investigación en Epidemiología y Servicios de Salud Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Aim: We aimed at performing a situation analysis to identify challenges that Mexico's peritoneal dialysis centers (PDCs) have faced before and during the COVID-19 pandemic.

Methods: From May-August 2021, we conducted a cross-sectional nationwide online survey with the heads of 136 PDCs at the Mexican Institute of Social Security. The survey gathered information about PDCs characteristics and the adaptations and challenges they faced before and during the COVID-19 pandemic. Read More

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Vitamin D Receptor Gene Polymorphisms, β-cell Function, and Vitamin D Status in Non-obese Mexican Adults.

Arch Med Res 2022 Apr 29. Epub 2022 Apr 29.

Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Background: FokI (rs2228570 T>C) and BsmI (rs1544410 A>G) polymorphisms of the vitamin D receptor (VDR) have been associated to abnormal glucose metabolism and could be inversely associated with β-cell function (BCF) and vitamin D status. There is a lack of information about this topic in the Mexican population.

Aim Of The Study: To evaluate the relationship between VDR gene polymorphisms FokI and BsmI with BCF and vitamin D status in a population of non-obese Mexican adults. Read More

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Riociguat in the Treatment of Pulmonary Arterial Hypertension in Mexico.

Arch Med Res 2022 Apr 26. Epub 2022 Apr 26.

Departamento de Cardioneumología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address:

Pulmonary arterial hypertension (PAH) is a severe clinical condition that significantly affects patients' quality of life and survival. Since the emergence of prostanoids 45 years ago, different drugs acting on vasoconstriction/vasodilation mechanisms have been developed for the treatment of PAH. Current evidence shows that better results occur when combined therapy is initiated up-front with periodic and systematized evaluations for escalation and switching. Read More

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Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial.

Arch Med Res 2022 Apr 18. Epub 2022 Apr 18.

Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Background: Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect.

Objective: To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed individuals. Read More

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Sex Differences and Temporal Trends in Revascularization and Outcomes of ST-Elevation Myocardial Infarction in Older Adults in the United States.

Arch Med Res 2022 Apr 25. Epub 2022 Apr 25.

University of Southern California Keck School of Medicine, Los Angeles, California, USA. Electronic address:

Background: Previous studies have suggested that in-hospital mortality is higher in younger women with ST-segment elevation myocardial infarction (STEMI) than in men. However, more coronary artery disease diagnoses occurred in patients older than 60 years.

Aim Of The Study: This study sought to investigate the temporal trends and sex differences in revascularization and in-hospital outcomes in older STEMI patients. Read More

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Association of Gut Microbiota with Dietary-dependent Childhood Obesity.

Arch Med Res 2022 Apr 2. Epub 2022 Apr 2.

Epidemiología Genética, Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, México. Electronic address:

Aim: To evaluate the taxonomic profile of the gut microbiota using metagenomics and the association with diet-dependent childhood obesity.

Methods: A cross-sectional study of a subsample of 46 children was conducted. The children were classified as normal-weight, overweight, and obese according to their age and sex and the World Health Organization (WHO) guidelines. Read More

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Utility of a Pulmonary Oedema Score for Predicting the Need for Mechanical Ventilation in COVID-19 Patients in a General Hospital.

Arch Med Res 2022 Mar 22. Epub 2022 Mar 22.

Department of Family Medicine, McGill University, Montreal, Quebec, Canada.

Background: The Radiographic Assessment of Lung Edema (RALE) score has been used to estimate the extent of pulmonary damage in patients with acute respiratory distress syndrome and might be useful in patients with COVID-19.

Aim Of The Study: To examine factors associated with the need for mechanical ventilation in hospitalized patients with a clinical diagnosis of COVID-19, and to estimate the predictive value of the RALE score.

Methods: In a series of patients admitted between April 14 and August 28, 2020, with a clinical diagnosis of COVID-19, we assessed lung involvement on the chest radiograph using the RALE score. Read More

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Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia.

Arch Med Res 2022 Mar 30. Epub 2022 Mar 30.

Departamento de Genética, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México. Electronic address:

Background: Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia.

Aim Of The Study: We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive performance of Mexican-Mestizo adult patients with SCZ in order to identify endophenotypes. Read More

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NDC80 Enhances Cisplatin-resistance in Triple-negative Breast Cancer.

Arch Med Res 2022 Mar 25. Epub 2022 Mar 25.

Department of Radiology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China.

Backgrounds: Chemotherapy is a standard systemic treatment option for triple-negative breast cancer (TNBC). Cisplatin has been used to treat TNBC, but frequently leads to cisplatin resistance in patients. The aim of our study was to investigate cisplatin-resistant mechanism in TNBC. Read More

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Validation of the Nasal Obstruction Symptom Evaluation Scale in Mexican Adults.

Arch Med Res 2022 Apr 24;53(3):329-335. Epub 2022 Mar 24.

Departamento de Otorrinolaringología, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Ciudad de México, México. Electronic address:

Background: Nasal obstruction is a feeling of impaired airflow through the nose, caused by diverse factors with high prevalence. There are numerous methods to study it, being the most important subjective instrument the Nasal Obstruction Symptom Evaluation score, NOSE, with good structural validity and internal consistency. It has been translated and validated in several languages, including European Spanish, but hasn't been validated in Mexico. Read More

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Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial.

Arch Med Res 2022 Mar 14. Epub 2022 Mar 14.

Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cancer, Environmental and Petroleum Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background: Tranilast is a potential NLRP3 inflammasome inhibitor that may relieve progressive inflammation due to COVID-19.

Aim Of The Study: To evaluate the therapeutic effects of Tranilast in combination with antiviral drugs in non-ICU-admitted hospitalized patients with COVID-19.

Methods: This study was an open-label clinical trial that included 72 hospitals admitted patients with severe COVID-19 at Razi Hospital, Ahvaz, Iran, from July 2020-August 2020. Read More

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COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review.

Arch Med Res 2022 Apr 14;53(3):252-262. Epub 2022 Mar 14.

Unidad de Investigación de Análisis y Síntesis de Evidencia, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Background: COVID-19 is an infectious disease of variable severity caused by a new coronavirus. Clinical presentation ranges from asymptomatic cases to severe illness. Most cases in newborns appear to be asymptomatic or mild. Read More

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Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction.

Arch Med Res 2022 Apr 17;53(3):289-295. Epub 2022 Feb 17.

Institute of Biomedicine-iBiMED, School of Health Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:

Background: Endothelial dysfunction has been suggested as a potential mechanism contributing to the development and progression of heart failure (HF). Levels of circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), and hematopoietic stem and progenitor cells (HSPCs) have been recognized as useful markers of vascular damage and endothelial repair in response to tissue injury.

Aims: To evaluate the circulating levels of EPCs, CECs, and HSPCs among patients with HF with reduced ejection fraction (HFrEF). Read More

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LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis.

Arch Med Res 2022 Apr 12;53(3):271-279. Epub 2022 Feb 12.

Department of Pediatrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China. Electronic address:

Background: Diffuse large-B-cell lymphoma (DLBCL), as the most common subtype of B Cell Non-Hodgkin lymphoma (B-NHL), is one of the lymphoid malignancies with poor prognosis worldwide. Non-coding RNA activated by the DNA damage (NORAD), a novel identified lncRNA involved in the DNA repairment process, is reportedly to participate in carcinogenesis, and it is predicted to sponge miR-345-3p. However, LncRNA NORAD has never been investigated in DLBCL. Read More

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Neuroendocrine-immune Interface: Interactions of Two Complex Systems in Health and Disease.

Arch Med Res 2022 Apr 10;53(3):240-251. Epub 2022 Feb 10.

Unidad de Investigación Medica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

The relationship between the neuroendocrine and the immune systems is essential to maintain homeostasis. Their complex interactions are present in many physiological or pathological states whereby hormones exert different actions in immune system cells and vice versa. Hormones such as prolactin, growth hormone, cortisol and sex hormones are known to regulate the differentiation and function of immune system cells and the production of cytokines. Read More

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A Multimodal Strategy to Reduce the Risk of Hospitalization/death in Ambulatory Patients with COVID-19.

Arch Med Res 2022 Apr 24;53(3):323-328. Epub 2022 Jan 24.

Dirección de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Background: Different interventions have been implemented worldwide for the house-hold monitoring of patients with mild COVID-19 to reduce the burden of healthcare systems and guarantee quality of care. Telephone follow up and treatment kits have not been evaluated in the context of a national-wide primary care program.

Aim Of The Study: To compare the risk of hospitalization and death for COVID-19 between ambulatory patients who received and those who did not receive a treatment kit and telephone follow-up in a developing country METHODS: A two-group comparative analysis was conducted using data from the medical information systems of the Mexican Institute of Social Security. Read More

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Is Omicron the last SARS-CoV-2 Variant of Concern?

Arch Med Res 2022 Apr 19;53(3):336-338. Epub 2022 Jan 19.

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

Millions have died due to the COVID-19 pandemic. The irrepressible propensity of the pandemic, which was highlighted by the outbreak of the Delta variant, should not be underestimated. The Omicron SARS-CoV-2 variant is thought to have originated from Africa. Read More

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Nitazoxanide and Cancer Drug Resistance: Targeting Wnt/β-catenin Signaling Pathway.

Arch Med Res 2022 Apr 20;53(3):263-270. Epub 2021 Dec 20.

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objectives: One of the most important complications that lead to unsuccessful treatment of cancer is resistance against chemotherapy agents, so called multidrug resistance (MDR). Thus, identification of the novel medications with low side effects and high efficacy to reverse MDR is highly required. Accordingly, the current study was performed to investigate the molecular mechanism of MDR in LS174T and LS174T/Oxaliplatin (OXP) cell lines during treatment with Nitazoxanide (NTZ) in combination with OXP. Read More

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Role of Ginsenosides in Browning of White Adipose Tissue to Combat Obesity: A Narrative Review on Molecular Mechanism.

Arch Med Res 2022 Apr 11;53(3):231-239. Epub 2021 Dec 11.

Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do, Republic of Korea. Electronic address:

Background And Aims: Adipose tissue play an important role in the regulation of energy balance and homeostasis. Two main types of adipose tissue are found in mammals, white adipose tissue (WAT) and brown adipose tissue (BAT). WAT acts as energy storage in the form of triglycerides; excess WAT is a cause of overweight and obesity. Read More

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Multiple Sclerosis-associated Bacterial Ligand 654.

Arch Med Res 2022 02 9;53(2):157-162. Epub 2021 Dec 9.

Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA. Electronic address:

Background And Aims: Many endogenous and exogenous risk factors are associated with multiple sclerosis (MS), but recent studies suggest that microbiome-derived ligands, play a role in the disease process. The goal of this study was to characterize the cellular response elicited in human microglia upon treatment with IFN-β and Fingolimod, two first line medications for the management of MS, and determine whether these treatments affect the response of microglial cells to an MS-associated bacterial ligand, Lipid 654.

Materials And Methods: HMC3 human microglial cells were treated with IFN-β or Fingolimod. Read More

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February 2022

LncRNA CASC9-1 Facilitates Cell Malignant Behaviors in Cervical Squamous Cell Carcinoma by Targeting miR-383-5p to Up-regulate MAPKAP1.

Arch Med Res 2022 02 30;53(2):138-146. Epub 2021 Nov 30.

Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Background: Cervical squamous cell carcinoma (Cervical SCC) is a malignant gynecological tumor, which greatly endangers the health of global women. Cancer susceptibility candidate 9 (CASC9) has been identified as an oncogene in multiple cancers. However, the role of CASC9-1 (one transcript of CASC9) in cervical SCC remains covered. Read More

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February 2022

Impact of Polycystic Ovary Syndrome on Silent Coronary Artery Disease and Cardiovascular Events; A Long-term Population-based Cohort Study.

Arch Med Res 2022 Apr 22;53(3):312-322. Epub 2021 Nov 22.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The existing data regarding the impact of Polycystic Ovary Syndrome (PCOS) on the risk of developing cardiovascular disease (CVD) are conflicting.

Aim: To explore the effect of PCOS status on the occurrence of silent coronary artery disease (CAD)/CVD.

Methods: A total of 1591 women without CVD at baseline, aged 18-45 years, including 356 PCOS patients (defined by the Rotterdam criteria) and 1235 eumenorrheic non-hirsute women without polycystic ovarian morphology (controls), were selected from the Tehran Lipid and Glucose Study (TLGS). Read More

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Trends in Medical Specialization and Employability in Mexico According to Gender.

Arch Med Res 2022 02 16;53(2):205-214. Epub 2021 Nov 16.

Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México; Universidad de las Américas, Ciudad de México, México.

Background: Feminization of medicine is a worldwide phenomenon. Countries must consider feminization of medical specializations in the planning of health public politics.

Objective: To analyze trends in medical specialization and employability in México according to gender. Read More

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February 2022

Increased Rate of Protease Inhibitor-resistance Associated Mutations in Human Immunodeficiency Viruses Infecting Mexicans who Had Been Living Abroad.

Arch Med Res 2022 Apr 5;53(3):296-303. Epub 2021 Nov 5.

Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Ciudad de México, México. Electronic address:

Background: Migrants face multiple barriers to accessing health services and antiretroviral therapy (ART). We tested the hypothesis that HIV-infected ART-experienced Mexicans with a history of residence in the U.S. Read More

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