412 results match your criteria Archives Of Endocrinology Metabolism[Journal]


Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristics of PTC.

Subjects And Methods: We retrospectively enrolled in the study a total of 43 consecutive PTC patients who underwent total thyroidectomy. We performed DNA extraction from formalin-fixed paraffin-embedded (FFPE) tumour tissue samples. Read More

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http://dx.doi.org/10.20945/2359-3997000000120DOI Listing
March 2019
1 Read

Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: Nonalcoholic fatty liver disease is the commonest diffuse liver disease, of which women with polycystic ovary syndrome are at an increased risk. The aim of the present study was to assess the diagnostic value of the semiquantitative strain parameters of real-time ultrasound elastography for nonalcoholic fatty liver disease in patients with polycystic ovary syndrome.

Subjects And Methods: Thirty-five polycystic ovary syndrome patients with nonalcoholic fatty liver disease, 70 polycystic ovary syndrome patients without nonalcoholic fatty liver disease, and 70 healthy female controls of reproductive age were included. Read More

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http://dx.doi.org/10.20945/2359-3997000000119DOI Listing
March 2019
1 Read

Correlation analysis between short-term insulin-like growth factor-I and glucose intolerance status after transsphenoidal adenomectomy in acromegalic patients: a large retrospective study from a single center in China.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Neurosurgery, Peking Union Medical College Hospital, Peking, China.

Objectives: Our study aimed to investigate the associations of glucose tolerance status with insulin-like growth factor-I (IGF-I) and other clinical laboratory parameters of acromegalic patients before and after the patients underwent transsphenoidal adenomectomy (TSA) by conducting a single-center, retrospective study.

Subjects And Methods: A total of 218 patients with acromegaly who had undergone TSA as the first treatment were retrospectively analyzed. Serum IGF-I, growth hormone (GH) and glucose levels were measured before and after surgery. Read More

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http://dx.doi.org/10.20945/2359-3997000000118DOI Listing
March 2019
1 Read

Serum PTH reference values in an adult Brazilian population: implications for the diagnosis of hyperparathyroidism.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: To define serum parathyroid hormone (PTH) reference values in carefully selected subjects following the recommended pre-analytical guidelines.

Subjects And Methods: First, 676 adults who would be submitted to thyroidectomy were evaluated. Patients using interfering medications or with malabsorption syndrome, hypomagnesemia, hyper- or hypophosphatemia, hypo- or hypercalcemia, 25-hydroxyvitamin D < 30 ng/dL, estimated glomerular filtration rate < 60 mL/min/1. Read More

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http://dx.doi.org/10.20945/2359-3997000000117DOI Listing
March 2019
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Preoperative detection of TERT promoter and BRAFV600E mutations in papillary thyroid carcinoma in high-risk thyroid nodules.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Ciências da Saúde, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.

Objectives: This observational study analyzed telomerase reverse transcriptase (pTERT) mutations in 45 fine-needle aspiration (FNA) specimens obtained from thyroid nodules followed by postoperatively confirmation of papillary thyroid cancer (PTC) diagnosis, examining their relationship with clinicopathologic aspects and the BRAFV600E mutation.

Subjects And Methods: Clinical information was collected from patients who presented to Ribeirao Preto University Hospital for surgical consultation regarding a thyroid nodule and who underwent molecular testing between January 2010 to October 2012. Tests included a DNA-based somatic detection of BRAFV600E and pTERT mutations. Read More

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http://dx.doi.org/10.20945/2359-3997000000116DOI Listing
March 2019
1 Read

Epidemiological study of metabolic syndrome in Brazilian soldiers.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Instituto de Pesquisa da Capacitação Física do Exército (IPCFEx), Rio de Janeiro, RJ, Brasil.

Objective: The aim of this study was to carry out an epidemiological analysis of metabolic syndrome among Brazilian Army soldiers.

Subjects And Methods: Two thousand seven hundred and nineteen male soldiers of the Brazilian Army were evaluated from 2014 to 2016. Characteristics: age = 27. Read More

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http://dx.doi.org/10.20945/2359-3997000000115DOI Listing

Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Medicina Interna, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil.

Objective: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor α (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway.

Materials And Methods: The cell line was treated with T3 at a physiological dose (10-9M) for 10 minutes, 1 and 4 hour (h) in the presence or absence of the inhibitors, α-amanitin (RNA polymerase II inhibitor) and PD98059 (MAPK/ERK pathway inhibitor). TGFA mRNA expression was analyzed by RT-PCR. Read More

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http://dx.doi.org/10.20945/2359-3997000000114DOI Listing
March 2019
1 Read

Is thyroid nodule volume predictive for malignancy?

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Yildirim Beyazit University, School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.

Objective: We aimed to determine the roles of preoperative thyroid nodule diameter and volume in the prediction of malignancy.

Subjects And Methods: The medical records of patients who underwent thyroidectomy between January 2007 and December 2014 were reviewed. The nodule diameters were grouped as < 1 cm, 1-1. Read More

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http://dx.doi.org/10.20945/2359-3997000000113DOI Listing
March 2019
1 Read

Serum calcitonin nadirs to undetectable levels within 1 month of curative surgery in medullary thyroid cancer.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Medicine, Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Objective: Because serum calcitonin (CT) is a reliable marker of the presence, volume, and extent of disease in medullary thyroid cancer (MTC), both the ATA and NCCN guidelines use the 2-3 month post-operative CT value as the primary response to therapy variable that determines the type and intensity of follow up evaluations. We hypothesized that the calcitonin would nadir to undetectable levels within 1 month of a curative surgical procedure.

Subjects And Methods: This retrospective review identified 105 patients with hereditary and sporadic MTC who had at least two serial basal CT measurements done in the first three months after primary surgery. Read More

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http://dx.doi.org/10.20945/2359-3997000000112DOI Listing
March 2019
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Effects of a new approach of aerobic interval training on cardiac autonomic modulation and cardiovascular parameters of metabolic syndrome subjects.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Educação Física, Universidade Estadual Paulista, Presidente Prudente, São Paulo, Brasil.

Objective: To evaluate the effects of 16 weeks of periodized aerobic interval training (AIT) on cardiac autonomic modulation and cardiovascular parameters of metabolic syndrome (Mets) individuals.

Subjects And Methods: The sample was composed of 52 subjects with a diagnosis of Mets, allocated into two groups: AIT (AITG; n = 26) and control (CG; n = 26). The AITG was submitted to a periodized AIT program, over 16 weeks, while CG was not submitted to any training program. Read More

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http://dx.doi.org/10.20945/2359-3997000000111DOI Listing

A rare mutation in hypophosphatasia: a case report of adult form and review of the literature.

Arch Endocrinol Metab 2019 Feb;63(1):89-93

Emory University School of Medicine, Diabetes and Endocrinology Section, Atlanta, GA, USA.

Hypophosphatasia is a rare inborn error of metabolism characterized by low serum alkaline phosphatase activity due to loss-of-function mutations in the gene encoding the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Extracellular accumulation of TNSALP substrates leads to dento-osseous and arthritic complications featuring tooth loss, rickets or osteomalacia, and calcific arthopathies. Mild hypophosphatasia usually has autosomal dominant inheritance, severe cases are either autosomal recessive or due to a dominant negative effect. Read More

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http://dx.doi.org/10.20945/2359-3997000000108DOI Listing
February 2019
2 Reads

Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.

Arch Endocrinol Metab 2019 Feb;63(1):84-88

Pediatric Endocrinology Unit, Coimbra Hospital and University Center, Coimbra, Portugal.

Hyperreninemic hypoaldosteronism due to aldosterone synthase (AS) deficiency is a rare condition typically presenting as salt-wasting syndrome in the neonatal period. A one-month-old Portuguese boy born to non-consanguineous parents was examined for feeding difficulties and poor weight gain. A laboratory workup revealed severe hyponatremia, hyperkaliaemia and high plasma renin with unappropriated normal plasma aldosterone levels, raising the suspicion of AS deficiency. Read More

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http://dx.doi.org/10.20945/2359-3997000000107DOI Listing
February 2019
2 Reads

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy.

Arch Endocrinol Metab 2019 Feb;63(1):79-83

Grupo Brasileiro para Estudos de Lipodistrofias Herdadas e Adquiridas (BRAZLIPO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Read More

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http://dx.doi.org/10.20945/2359-3997000000096DOI Listing
February 2019
3 Reads

Genetic causes of isolated short stature.

Arch Endocrinol Metab 2019 Feb;63(1):70-78

Unidade de Endocrinologia Genética (LIM25), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brasil.

Short stature is a common feature, and frequently remains without a specific diagnosis after conventional clinical and laboratorial evaluation. Longitudinal growth is mainly determined by genetic factors, and hundreds of common variants have been associated to height variability among healthy individuals. Although isolated short stature may be caused by the combination of variants, with a deleterious impact on the growth of individuals with polygenic inheritance, recent studies have pointed out some monogenic defects as the cause of the growth disorder observed in nonsyndromic children. Read More

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http://dx.doi.org/10.20945/2359-3997000000105DOI Listing
February 2019

Low levels of dehydroepiandrosterone sulfate are associated with the risk of developing cardiac autonomic dysfunction in elderly subjects.

Arch Endocrinol Metab 2019 Feb;63(1):62-69

Departamento de Ciências do Esporte, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brasil.

Objective: To assess the relationships between serum dehydroepiandrosterone sulfate (DHEA-S) levels and heart rate variability (HRV) among different age groups.

Subjects And Methods: Forty-five healthy men were divided into 3 groups: young age (YA; 20-39 yrs; n = 15), middle age (MA; 40-59 yrs; n = 15) and old age (OA; ≥ 60 yrs; n = 15). Hemodynamic parameters, linear analyses of HRV and concentrations of cortisol and DHEA-S were measured at rest. Read More

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http://dx.doi.org/10.20945/2359-3997000000104DOI Listing
February 2019

Basal metabolic rate in Brazilian patients with type 2 diabetes: comparison between measured and estimated values.

Arch Endocrinol Metab 2019 Feb;63(1):53-61

Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.

Objectives: The aims of this study are to investigate which of the seven selected predictive equation for estimating basal metabolic rate (BMR) is the best alternative to indirect calorimetry (IC) and to evaluate the dietary energy intake in patients with type 2 diabetes.

Subjects And Methods: Twenty-one patients with type 2 diabetes participated in this diagnostic test study. Clinical and laboratorial variables were evaluated as well as body composition by absorptiometry dual X-ray emission (DXA) and BMR measured by IC and estimated by prediction equations. Read More

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http://dx.doi.org/10.20945/2359-3997000000103DOI Listing
February 2019
1 Read

Clinical and hormonal characteristics of patients with different types of hypophysitis: a single-center experience.

Arch Endocrinol Metab 2019 Feb;63(1):47-52

Saglik Bilimleri University, Ankara Numune Education and Research Hospital Department of Endocrinology and Metabolism, Ankara, Turkey.

Objective: The inflammation of the pituitary gland is known as hypophysitis. It is a rare disease accounting for approximately 0.24%-0. Read More

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http://dx.doi.org/10.20945/2359-3997000000102DOI Listing
February 2019
9 Reads

Influence of obesity in pulmonary function and exercise tolerance in obese women with obstructive sleep apnea.

Arch Endocrinol Metab 2019 Feb;63(1):40-46

Departamento de Educação Física, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brasil.

Objective: To evaluate the influence of obesity on pulmonary function and exercise tolerance in women with obstructive sleep apnea (OSA).

Subjects And Methods: A descriptive analytic cross- sectional study was carried out. Thirty-nine (39) sedentary climacteric women, aged 45 to 60 years, were evaluated and submitted to polysomnography. Read More

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http://dx.doi.org/10.20945/2359-3997000000101DOI Listing
February 2019
1 Read

Anthropometric measurements as a potential non-invasive alternative for the diagnosis of metabolic syndrome in adolescents.

Arch Endocrinol Metab 2019 Feb;63(1):30-39

Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo (FSP-USP), São Paulo, SP, Brasil.

Objective: To identify which anthropometric measurement would be the best predictor of metabolic syndrome (MetS) in Brazilian adolescents.

Subjects And Methods: Cross-sectional study conducted on 222 adolescents (15-17 years) from a city in southern Brazil. Anthropometric, physical activity, blood pressure and biochemical parameters were investigated. Read More

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http://dx.doi.org/10.20945/2359-3997000000100DOI Listing
February 2019
1 Read

Relationship between inflammatory markers, glycated hemoglobin and placental weight on fetal outcomes in women with gestational diabetes.

Arch Endocrinol Metab 2019 Feb;63(1):22-29

Unidade de Diabetes, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brasil.

Objective: The aim of this study was to evaluate the relationship between inflammatory cytokines, placental weight, glycated hemoglobin and adverse perinatal outcomes (APOs) in women with gestational diabetes mellitus (GDM).

Subjects And Methods: This was a prospective, longitudinal and observational study conducted from April 2004 to November 2005 in Bauru, Brazil. Included patients had singleton pregnancies and performed a 100 g OGTT and had the levels of C-reactive protein (CRP), interleukin (IL)-6, TNF alfa and glycated hemoglobin (HbA1c) determined at 24-28th gestation weeks. Read More

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http://dx.doi.org/10.20945/2359-3997000000099DOI Listing
February 2019

Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism.

Arch Endocrinol Metab 2019 Feb;63(1):16-21

Department of Anesthesiology and Algology, Ataturk Research and Training Hospital, Izmir, Turkey.

Objective: In this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT).

Subjects And Methods: The study included 160 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto's thyroiditis and 86 euthyroid healty subjects. Serum glucose and lipid profile, insulin, HOMA, TSH, free T3, free T4, anti-thyroperoxidase and anti-thyroglobulin antibodies, homocysteine, apelin and irisin levels were measured in all study subjects. Read More

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http://dx.doi.org/10.20945/2359-3997000000106DOI Listing
February 2019
1 Read

Does the Bethesda category predict aggressive features in differentiated thyroid cancer?

Arch Endocrinol Metab 2019 Feb;63(1):12-15

Serviço de Endocrinologia do Hospital Universitário da Universidade Federal do Maranhão (UFMA), São Luís, MA, Brasil.

Objective: To analyze the importance of preoperative cytology of thyroid nodules and its relationship with mortality risk, recurrence risk, dynamic stratification, and aggressive characteristics (vascular invasion, aggressive histology, incomplete tumor resection, extrathyroidal extension of the tumor, and presence of lymph node and distant metastases).

Subjects And Methods: Retrospective evaluation of 153 patients diagnosed with differentiated thyroid carcinoma (DTC) and following up at the Hospital Universitário Presidente Dutra between January 1999 and December 2016.

Results: In all, 96% of the patients were female, 79. Read More

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http://dx.doi.org/10.20945/2359-3997000000098DOI Listing
February 2019
1 Read

Impact of the updated TNM staging criteria on prediction of persistent disease in a differentiated thyroid carcinoma cohort.

Arch Endocrinol Metab 2019 Feb;63(1):5-11

Grupo de Tireoide, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, RS, Brasil.

Objective: The 8th TNM system edition (TNM-8) released in 2018 presents significant changes when compared to the 7th edition (TNM-7). The aim of this study was to assess the impact of changing the TNM staging criteria on the outcomes in a Brazilian cohort of differentiated thyroid carcinoma (DTC).

Subjects And Methods: DTC patients, attending a tertiary, University-based hospital, were classified by TNM-7 and TNM-8. Read More

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http://dx.doi.org/10.20945/2359-3997000000097DOI Listing
February 2019
1 Read

Clinical risk predictors for differentiated thyroid cancer management: what is new?

Authors:
Denise Momesso

Arch Endocrinol Metab 2019 Feb;63(1):2-4

Departamento de Endocrinologia, Universidade Federal do Rio de Janeiro (UFRJ). Faculdade de Medicina, Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000110DOI Listing
February 2019

AE&M's first issue of the year: important news!

Arch Endocrinol Metab 2019 Feb;63(1)

Editor-chefe da Archives of Endocrinology and Metabolism, chefe da Unidade de Neuroendocrinologia, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000109DOI Listing
February 2019

Hypothyroidism associated with short bowel syndrome in children: a report of six cases.

Arch Endocrinol Metab 2018 ;62(6):655-660

Serviço de Cirurgia Pediátrica e Transplante Hepático, Laboratório de Investigação em Cirurgia Pediátrica (LIM-30), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil.

Short bowel syndrome (SBS) is the leading cause of intestinal failure in children, a condition of absence of sufficient bowel to meet the nutritional and metabolic needs of a growing individual. The treatment of patients in this situation is based on the association of parenteral and enteral nutrition for prolonged periods of time until intestinal rehabilitation occurs with complete enteral nutrition autonomy. Six consecutive cases of children with SBS (residual intestinal length of 5 cm to 75 cm) were managed with this program and were diagnosed with associated hypothyroidism during the treatment (ages at the diagnosis 5 months to 12 years). Read More

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http://dx.doi.org/10.20945/2359-3997000000093DOI Listing
February 2019
16 Reads

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
5 Reads

Early development of a gonadal tumor in a patient with mixed gonadal dysgenesis.

Arch Endocrinol Metab 2018 ;62(6):644-647

Grupo Interdisciplinar de Estudos da Determinação e Diferenciação do Sexo (GIEDDS), Faculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM-Unicamp), Campinas, SP, Brasil.

A gonadal tumor was diagnosed in the first months of life in a patient with genital ambiguity, a 45,X/46,XY karyotype, and mixed gonadal dysgenesis. Gonadal biopsies at the age of 3 months revealed dysgenetic testes and a gonadoblastoma on the right testis. Even though gonadal tumors are rare in childhood, this case indicates that prophylactic removal of dysgenetic gonads should be performed as early as possible, especially when the female sex is assigned to a patient with a Y-chromosome sequence. Read More

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http://dx.doi.org/10.20945/2359-3997000000091DOI Listing
February 2019
3 Reads

Selective screening for thyroid dysfunction in pregnant women: How often do low-risk women cease to be treated following the new guidelines of the American Thyroid Association?

Arch Endocrinol Metab 2018 ;62(6):641-643

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: Universal screening for thyroid dysfunction in pregnant women is not recommended by the American Thyroid Association (ATA) or the American Association of Clinical Endocrinologists (AACE). This study evaluated the frequency of pregnant women that would have an indication for levothyroxine (L-T4) according to the new ATA/AACE guidelines among low-risk women without an indication for screening with TSH.

Subjects And Methods: The sample consisted of 412 pregnant women ranging in age from 18 to 30 years. Read More

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http://dx.doi.org/10.20945/2359-3997000000089DOI Listing
February 2019

Rare complications of multikinase inhibitor treatment.

Arch Endocrinol Metab 2018 ;62(6):636-640

Division of Endocrinology, University of Buenos Aires, Buenos Aires, Argentina.

Objective: The advent of multikinase inhibitor (MKI) therapy has led to a radical change in the treatment of patients with advanced thyroid carcinoma. The aim of this manuscript is to communicate rare adverse events that occurred in less than 5% of patients in clinical trials in a subset of patients treated in our hospital.

Subjects And Methods: Out of 760 patients with thyroid cancer followed up with in our Division of Endocrinology, 29 (3. Read More

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http://dx.doi.org/10.20945/2359-3997000000090DOI Listing
February 2019
13 Reads

A pioneering RET genetic screening study in the State of Ceará, Brazil, evaluating patients with medullary thyroid cancer and at-risk relatives: experience with 247 individuals.

Arch Endocrinol Metab 2018 ;62(6):623-635

Centro de Doenças da Tiroide e Laboratório de Endocrinologia Molecular e Translacional, Divisão de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brasil.

Objective: Initial diagnosis of medullary thyroid carcinoma (MTC) is frequently associated with advanced stages and a poor prognosis. Thus, the need for earlier diagnoses and detection in relatives at risk for the disease has led to increased use of RET genetic screening.

Subjects And Methods: We performed RET screening in 247 subjects who were referred to the Brazilian Research Consortium for Multiple Endocrine Neoplasia (BRASMEN) Center in the State of Ceará. Read More

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http://dx.doi.org/10.20945/2359-3997000000088DOI Listing
February 2019
2 Reads

Sex effects on the association between sarcopenia EWGSOP and osteoporosis in outpatient older adults: data from the SARCOS study.

Arch Endocrinol Metab 2018 ;62(6):615-622

Disciplina de Cardiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brasil.

Objective: The objective was to evaluate the association between sarcopenia (EWGSOP) and osteoporosis in older adults.

Subjects And Methods: This is a cross sectional analysis of a baseline evaluation of the SARCopenia and OSteoporosis in Older Adults with Cardiovascular Diseases Study (SARCOS). Three hundred and thirty-two subjects over 65 years of age were evaluated. Read More

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http://dx.doi.org/10.20945/2359-3997000000087DOI Listing
February 2019

Conversion to Graves disease from Hashimoto thyroiditis: a study of 24 patients.

Arch Endocrinol Metab 2018 ;62(6):609-614

Department of Endocrinology, CHU, Liège, Belgium.

Objective: The conversion of Hashimoto's thyroiditis (HT) to hyperthyroidism due to thyrotropin receptor antibodies is intriguing and considered rare. The contribution of TSH receptor blocking antibodies (TRAb), which may be stimulators (TSAb) or blockers (TBAb), is suspected. We describe clinical and biological variables in a series of patients switching from Hashimoto's thyroiditis to Grave's disease. Read More

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http://dx.doi.org/10.20945/2359-3997000000086DOI Listing
February 2019
1 Read

Higher prevalence of permanent congenital hypothyroidism in the Southwest of Iran mostly caused by dyshormonogenesis: a five-year follow-up study.

Authors:
Majid Aminzadeh

Arch Endocrinol Metab 2018 ;62(6):602-608

Division of Pediatric Endocrinology and Metabolism, Pediatric Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: The incidence of congenital hypothyroidism (CH) varies globally. This 5-year study aimed to determine the prevalence of permanent CH in the southwest of Iran.

Materials And Methods: Between January 2007 and December 2009, all newborns in Ahvaz, the biggest city in the southwest of Iran, were screened for CH using a heel-prick sample for thyrotropin (TSH) levels. Read More

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http://dx.doi.org/10.20945/2359-3997000000085DOI Listing
February 2019

Risk factors for new-onset diabetes mellitus after kidney transplantation (NODAT): a Brazilian single center study.

Arch Endocrinol Metab 2018 ;62(6):597-601

Universidade Evangélica, Departamento de Medicina, Curitiba, PR, Brasil.

Objectives: This study aims to verify the new-onset diabetes after kidney transplant (NODAT) incidence in recipients within 1 year after kidney transplantation from a single center in Southern Brazil and to assess the associated conditions.

Subjects And Methods: A retrospective study of 258 post-renal transplant patients was performed. Demographic (gender, age, ethnic background) and clinical (origin of graft, associated infections, body mass index (BMI) at transplant time and 6 and 12 months after, causes of renal failure, and comorbidities) data were analyzed. Read More

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http://dx.doi.org/10.20945/2359-3997000000084DOI Listing
February 2019
1 Read

Heart rate response to graded exercise test of elderly subjects in different ranges of TSH levels.

Arch Endocrinol Metab 2018 ;62(6):591-596

Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho (HUCFF), Rio de Janeiro, RJ, Brasil.

Objective: Life expectancy is increasing worldwide and studies have been demonstrating that elevated serum thyroid stimulating hormone (TSH) concentration in elderly is associated with some better health outcomes. This elevation is somewhat physiological as aging. The aim of this study was to investigate the heart rate (HR) response during a graded exercise test and its recovery in healthy elderly, comparing subjects within serum TSH in the lower limit of reference range to those within the TSH in the upper limit. Read More

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http://dx.doi.org/10.20945/2359-3997000000083DOI Listing
February 2019
1 Read

The characteristics of blood glucose fluctuations in patients with fulminant type 1 diabetes mellitus in the stable stage.

Arch Endocrinol Metab 2018 ;62(6):585-590

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: The aim was to characterize blood glucose fluctuations in patients with fulminant type 1 diabetes (FT1DM) at the stable stage using continuous blood glucose monitoring systems (CGMSs).

Subjects And Methods: Ten patients with FT1DM and 20 patients with classic type 1 diabetes mellitus (T1DM) (the control group) were monitored using CGMSs for 72 hours.

Results: The CGMS data showed that the mean blood glucose (MBG), the standard deviation of the blood glucose (SDBG), the mean amplitude glycemic excursions (MAGE), the blood glucose areas and the percentages of blood glucose levels below 13. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.20945/2359-3997000000082DOI Listing
February 2019
2 Reads

Can current molecular tests help in the diagnosis of indeterminate thyroid nodule FNAB?

Authors:
Carolina Ferraz

Arch Endocrinol Metab 2018 ;62(6):576-584

Unidade de Doenças da Tireoide, Divisão de Endocrinologia, Departamento de Medicina, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

Approximately 15-30% of all thyroid nodules evaluated with fine-needle aspiration biopsy (FNAB) are classified as cytologically indeterminate. The stepwise unraveling of the molecular etiology of thyroid nodules has provided the basis for a better understanding of indeterminate samples and an opportunity to decrease diagnostic surgery in this group of patients. Over the last 15 years, several studies have tested different methodologies to detect somatic mutations (by polymerase chain reaction and next-generation sequencing, for example), and to identify differentially expressed genes or microRNA, aiming at developing molecular tests to improve the presurgical diagnosis of cytologically indeterminate nodules. Read More

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http://dx.doi.org/10.20945/2359-3997000000081DOI Listing
February 2019
3 Reads

Critical analysis of molecular tests in indeterminate thyroid nodules.

Arch Endocrinol Metab 2018 ;62(6):572-575

Laboratório de Endocrinologia Celular e Molecular (LIM25), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000095DOI Listing
January 2018

The challenge continues.

Arch Endocrinol Metab 2018 ;62(6):571

Editor-chefe da Archives of Endocrinology and Metabolism, chefe da Unidade de Neuroendocrinologia, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000094DOI Listing
January 2018
2 Reads

Insulin autoimmune syndrome in an occidental woman: a case report and literature review.

Arch Endocrinol Metab 2018 Oct;62(5):566-570

Serviço de Endocrinologia e Diabetes, Hospital Universitário Walter Cantídio - Faculdade de Medicina, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Insulin autoimmune syndrome (IAS, Hirata's disease) is a rare hypoglycemic disorder characterized by spontaneous hypoglycemia associated with extremely high circulating insulin levels and positive anti-insulin antibody results. Thus far, most cases have been reported in Asian countries, notably Japan, with few cases reported in western countries. As a possible cause, it is associated with the use of drugs containing sulfhydryl radicals, such as captopril. Read More

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http://dx.doi.org/10.20945/2359-3997000000078DOI Listing
October 2018
12 Reads

Congenital hyperinsulinism in two siblings with ABCC8 mutation: same genotype, different phenotypes.

Arch Endocrinol Metab 2018 Oct;62(5):560-565

Unidad de Endocrinología Pediátrica y Crecimiento, Pediatría, Hospital Clínico Universitario y Universidad de Santiago de Compostela, IDIS, Santiago de Compostela, Spain.

Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. Read More

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http://dx.doi.org/10.20945/2359-3997000000077DOI Listing
October 2018
9 Reads

Lipid disorders among Black Africans non-users of lipid-lowering medication.

Arch Endocrinol Metab 2018 Oct;62(5):552-559

Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brasil.

Objective: Angola is a sub-Saharan African country where the population has scarce access to lipidlowering medication. We sought to determine the frequency of lipid disorders among Angolan nonusers of lipid-lowering medication.

Material And Methods: A cross-sectional descriptive study was carried out in a sample of 604 workers from the public sector. Read More

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http://dx.doi.org/10.20945/2359-3997000000076DOI Listing
October 2018
20 Reads

Evaluation of redox profiles in exogenous subclinical hyperthyroidism at two different levels of TSH suppression.

Arch Endocrinol Metab 2018 Oct;62(5):545-551

Departamento de Endocrinologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0. Read More

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http://dx.doi.org/10.20945/2359-3997000000075DOI Listing
October 2018
17 Reads

Thyroid cancer burden and economic impact on the Brazilian public health system.

Arch Endocrinol Metab 2018 Oct;62(5):537-544

Divisão de Economia da Saúde, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: Recent data indicates an increasing incidence of thyroid cancer not accompanied by a proportional increase in mortality, suggesting overdiagnosis, which may represent a big public health problem, particularly where resources are scarce. This article aims to describe and evaluate the procedures related to investigation of thyroid nodules and treatment and follow-up of thyroid cancer and the costs for the Brazilian public health system between 2008 and 2015.

Materials And Methods: Data on procedures related to investigation of thyroid nodules and treatment/follow-up of thyroid cancer between 2008 and 2015 in Brazil were collected from the Department of Informatics of the Brazilian Unified Health System (Datasus) website. Read More

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http://dx.doi.org/10.20945/2359-3997000000074DOI Listing
October 2018
11 Reads

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial.

Arch Endocrinol Metab 2018 Oct;62(5):530-536

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training.

Subjects And Methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26. Read More

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http://dx.doi.org/10.20945/2359-3997000000073DOI Listing
October 2018
16 Reads

ABSI is a poor predictor of insulin resistance in Chinese adults and elderly without diabetes.

Arch Endocrinol Metab 2018 Oct;62(5):523-529

Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Recently, a new obesity index (A Body Shape Index, ABSI) based on waist circumference (WC) was developed, and high ABSI corresponds to a more central concentration of body volume. It is well known that central obesity is closely linked with insulin resistance (IR). Therefore, our study aimed to examine the discriminatory power of ABSI for IR in Chinese adults and elderly without diabetes. Read More

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http://dx.doi.org/10.20945/2359-3997000000072DOI Listing
October 2018
20 Reads

Impact of an inpatient multidisciplinary glucose control management program.

Arch Endocrinol Metab 2018 Oct;62(5):514-522

Hospital Pró-Cardíaco, Rio de Janeiro, RJ, Brasil.

Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of the implementation of an inpatient multidisciplinary glucose control management program on glucose control in hospitalized patients.

Materials And Methods: Retrospective analysis of medical records and glucose monitoring data obtained by point- of-care testing (POCT) in hospitalized patients before (May 2014) and after (June 2015 and May 2017) the implementation of the program. Read More

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http://dx.doi.org/10.20945/2359-3997000000071DOI Listing
October 2018
13 Reads

Is FGF-23 an early indicator of atherosclerosis and cardiac dysfunction in patients with gestational diabetes?

Arch Endocrinol Metab 2018 Oct;62(5):506-513

Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.

Objective: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone and plays a role in the pathogenesis of myocardial hypertrophy. The aim of this study was to evaluate the association of FGF-23 levels with echocardiographic parameters and insulin resistance (IR) in patients with gestational diabetes.

Subjects And Methods: Fifty-four pregnant patients with gestational diabetes mellitus (GDM) (age, 31. Read More

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http://dx.doi.org/10.20945/2359-3997000000070DOI Listing
October 2018
14 Reads

3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules.

Arch Endocrinol Metab 2018 Oct;62(5):501-505

The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Objective: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla MRS in the evaluation of patients with thyroid nodules (TNs) as an ancillary diagnostic technique for thyroid carcinoma.

Materials And Methods: Magnetic resonance spectroscopy at 3T at echo- times (TEs) 136 and 270 ms was carried out on 15 patients with total number of 32 TNs larger than 1 cm3, which all were surgically resected. Read More

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http://dx.doi.org/10.20945/2359-3997000000069DOI Listing
October 2018
13 Reads