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Arch Dermatol Res 2022 May 25. Epub 2022 May 25.

Clalit Health Services, Tel-Aviv, Israel.

Background: The association of vitiligo with psoriasis is inconsistent in the current literature.

Objective: To assess the bidirectional association between vitiligo and psoriasis.

Methods: A population-based study was performed to compare vitiligo patients (n = 20,851) with age-, sex- and ethnicity-matched control subjects (n = 102,475) regarding the incidence of new-onset and the prevalence of preexisting psoriasis. Read More

Arch Dermatol Res 2022 May 10. Epub 2022 May 10.

Department of Dermatology, CRB II, Johns Hopkins University School of Medicine, Suite 206, 1550 Orleans Street, Baltimore, MD, 21231, USA.

Little is known about the role nutritional factors play in the pathogenesis of chronic pruritic dermatoses (CPD). In this study, we analyzed nutritional deficiencies in CPD patients compared to matched controls. We conducted a population-based study from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006. Read More

Arch Dermatol Res 2022 May 9. Epub 2022 May 9.

Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, 20/24 Francuska St., 40-027, Katowice, Poland.

Recurrent changes of temperature and persistence of cooling along fingers at the room temperature make hands the most frequent region of interest for thermography in systemic sclerosis (SSc). The aim of this study was to evaluate dependance of temperature in hands on a subtype of the disease, immune profile of antinuclear antibodies (ANA), and lung involvement. There were 29 patients with limited cutaneous involvement (lcSSc) and 10 patients with diffuse cutaneous disease (dcSSc) enrolled for the study. Read More

Arch Dermatol Res 2022 Apr 27. Epub 2022 Apr 27.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, 222 East 41st Street, New York, NY, 10016, USA.

Deliberate practice-based medical education has demonstrated superiority in trainee acquisition and maintenance of skills in several surgical subspecialties. In an effort to highlight the impact of a deliberate practice-based surgical curriculum on the technical proficiency of dermatology residents, a prospective cohort study including first- and second-year dermatology residents was performed. A total of 87. Read More

Arch Dermatol Res 2022 Apr 25. Epub 2022 Apr 25.

Brooklyn Campus of the VA NY Harbor Healthcare System, 800 Poly Place, Brooklyn, NY, 11209, USA.

Incidence of basal cell carcinoma (BCC) with perineural invasion (PNI) ranges from 0.178 to 10% depending upon whether conventional pathology (formalin fixed, paraffin embedded) or Mohs micrographic surgery (MMS) (frozen sections) is used. To determine the incidence of BCC with PNI determined by conventional pathology versus MMS. Read More

Arch Dermatol Res 2022 Apr 13. Epub 2022 Apr 13.

Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Government-backed medical insurance plans have undergone significant changes in the last decade, but more information is needed to understand reimbursement trends, particularly for specialist medical services. The objective of this study was to identify the ratios of submitted dermatology service charges to allowed Medicare payments over the years. Further variables studied include regional or state variations, gender of provider, hierarchical condition category (HCC) risk scores of patient complexity, and number of services. Read More

Arch Dermatol Res 2022 Mar 23. Epub 2022 Mar 23.

Department of Dermatology, Andrology and STDs, Faculty of Medicine, Mansoura University, El-Gomhoria St., Mansoura, Egypt.

Vitiligo is acquired depigmentation due to multiple factors. Vitamin D in skin, through its receptors (VDR), regulates cell growth, differentiation, immune response and exerts both stimulatory and protective effects on melanocytes. The gene sequence encoding VDR has polymorphic forms such as ApaI and TaqI that may affect vitamin D actions. Read More

Arch Dermatol Res 2022 Mar 21. Epub 2022 Mar 21.

Veterans Affairs Medical Center, State University of New York Downstate, 800 Poly Place, Brooklyn, NY, 11209, USA.

Basal cell carcinoma and squamous cell carcinoma are the two most common types of carcinomas, affecting a total of 5.4 million people each year in the United States. Sun-exposed areas, especially the face and nose, are most affected given the strong association between these carcinomas and ultraviolet radiation. Read More

Arch Dermatol Res 2022 Mar 18. Epub 2022 Mar 18.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, 205 South Orange Ave, F1222, Newark, NJ, 07103, USA.

The objective is to determine the cost-effectiveness of sentinel lymph node biopsy (SLNB) for cutaneous squamous cell carcinoma (CSCC) according to the Brigham and Women's Hospital (BWH) Tumor Staging system. A decision analysis was utilized to examine costs and outcomes associated with the use of SLNB in patients with high-risk head and neck CSCC. Decision tree outcome probabilities were obtained from published literature. Read More

Arch Dermatol Res 2022 Mar 17. Epub 2022 Mar 17.

Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow Branch, Cracow, Poland.

External ear melanoma (EEM) belongs to extremely rare melanoma locations. So far, only single cases of EEM have been described in terms of dermoscopic presentations. This case study report presents dermoscopic patterns of EEM in six patients. Read More

Arch Dermatol Res 2022 Mar 14. Epub 2022 Mar 14.

Department of Dermatology, Cancer Research Building II, Johns Hopkins University School of Medicine, Suite 206 1550 Orleans Street, Baltimore, MD, 21231, USA.

Physicians are trending towards practice consolidation nationally; however, changes in dermatology practice size remain to be assessed. The objective of this study was to analyze trends in dermatology practice size from 2012 to 2020 using a large-scale Medicare physician database. We performed a retrospective cross-sectional analysis using 2012 and 2020 data obtained from the Physician Compare Database. Read More

Arch Dermatol Res 2022 Mar 13. Epub 2022 Mar 13.

Department of Dermatology, Icahn School of Medicine and Mount Sinai, New York, NY, 10029, USA.

Improved repigmentation of generalized vitiligo in skin types IV-VI has been reported in clinical response to combined therapy with apremilast and narrowband (NB)-UVB; however, tissue responses to combined therapy versus NB-UVB monotherapy have not been elucidated. We compared the change from baseline in cellular and molecular markers in vitiligo skin after combined therapy versus NB-UVB monotherapy. We assessed lesional and nonlesional skin samples from enrolled subjects and evaluated for immune infiltrates, inflammatory, and melanogenesis-related markers which were compared across different treatment groups. Read More

Arch Dermatol Res 2022 Mar 9. Epub 2022 Mar 9.

Department of Dermatology, the George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue NW Suite 2B-425, Washington, DC, 20037, USA.

Previous studies have found conflicting results about the association of autoimmune blistering disease (AIBD) with cardiovascular disease (CVD) risk. The objective of the study was to systematically review the relationship of AIBD, including pemphigus vulgaris (PV), and its treatment with CVD and CVD risk factors. MEDLINE, EMBASE, Cochrane, LILACS, SCOPUS, and Web of Science were searched. Read More

Arch Dermatol Res 2022 Mar 4. Epub 2022 Mar 4.

Sechenov Biomedical Science and Technology Park, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

A COS is a systematically developed list of outcomes recommended for reporting all studies within a particular disease area. The Cochrane Skin-Core Outcome Set Initiative (CS-COUSIN) and the Core Outcome Measures in Food Allergy (COMFA) Initiative Joint Meeting was held virtually on September 23 through 28, 2021. This meeting brought together core outcome set (COS) developers within the domains of dermatology and food allergy, respectively. Read More

Arch Dermatol Res 2022 Mar 4. Epub 2022 Mar 4.

Department of Dermatology, Wake Forest School of Medicine, 4618 Country Club Road, Winston-Salem, NC, 27104, USA.

While current studies have supported oral minoxidil as a novel, adjunctive therapy in non-scarring forms of alopecia, there continues to be limited data on oral minoxidil for these conditions. To assess oral minoxidil use in the treatment of androgenetic alopecia and telogen effluvium, a multi-center, retrospective analysis was conducted in 105 adult patients treated for androgenetic alopecia and/or telogen effluvium with oral minoxidil (dose range 0.625-2. Read More

Arch Dermatol Res 2022 Mar 2. Epub 2022 Mar 2.

Department of Dermatology, School of Medicine, University of Mississippi Medical Center, 2500 North State Street - L216, Jackson, MS, 39216, USA.

Skin cancer, including melanoma, is the most common cancer worldwide and a significant public health concern. A significant risk factor for melanoma is through increased exposure to ultraviolet (UV) radiation through the use of indoor tanning beds. Although rates of indoor tanning bed use have decreased in recent years, young adults, particularly White, college-age women, comprise the majority of indoor tanning bed users in the United States. Read More

Arch Dermatol Res 2022 Mar 1. Epub 2022 Mar 1.

Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alopecia areata/AA is an autoimmune cause of nonscarring hair loss. The pathogenesis of AA involves many immune axes, including Th1/Th2 pathways. Delgocitinib is a pan-Janus kinase/JAK inhibitor that broadly blocks pro-inflammatory cytokines and has been effective in other inflammatory skin conditions. Read More

Arch Dermatol Res 2022 Feb 28. Epub 2022 Feb 28.

Dermatology Department, Faculty of Medicine Kasr Alainy Hospitals, Cairo University, 174 Elyasmeen 2, 1st Settlement New Cairo, Cairo, Egypt.

Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma with proposed multifactorial etiology. Suppressor of cytokine signaling-3 (SOCS-3) is one of the proteins expressed in MF. Its exact role in disease pathogenesis has not yet been thoroughly investigated. Read More

Arch Dermatol Res 2022 Feb 28. Epub 2022 Feb 28.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Catecholamines (epinephrine, norepinephrine and dopamine) are considered toxic to the melanocytes and may play an important role in the development of depigmented patches on the skin. This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients' and gene expression changes in catecholamines' metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. In this single-centre, prospective, case-control study, 30 patients with active vitiligo were recruited and skin biopsies from the perilesional site and plasma samples were collected. Read More

Arch Dermatol Res 2022 Feb 26. Epub 2022 Feb 26.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Importance: Treatment of congenital ichthyoses primarily focuses on reversing skin scaling and is not pathogenesis based. Recent studies showed Th17 immune skewing, as in psoriasis, across the spectrum of ichthyosis, suggesting that targeting this pathway might broadly reduce disease severity.

Objective: To determine whether secukinumab, an IL-17A inhibitor, can improve ichthyosis across several congenital ichthyosis subtypes. Read More

Arch Dermatol Res 2022 Feb 25. Epub 2022 Feb 25.

Brooklyn Campus of the VA NY Harbor Healthcare System, FACMS, 800 Poly Place, Brooklyn, NY, USA.

Oculocutaneous albinism (OCA) is a group of rare, inherited disorders associated with reduced melanin biosynthesis. Clinical manifestations of the eight known subtypes of OCA include hypopigmented skin, eyes, and hair and ocular manifestations, such as decreased visual acuity and nystagmus. OCA affects people globally but is most prevalent in African countries. Read More

Arch Dermatol Res 2022 Feb 24. Epub 2022 Feb 24.

Harvard Medical School, Boston, MA, 02115, USA.

International medical graduates (IMGs) comprise a quarter of the United States (US) physician workforce but are a diminishing minority among dermatologists. Studies on IMGs in other specialties have demonstrated their importance in addressing provider shortage in rural and medically underserved areas (MUAs), but this trend has not been systematically explored within dermatology. This study aims to assess the state-by-state distribution of IMG dermatologists in the US as compared to US medical graduates (USMGs) with focus on provider density in rural settings and MUAs. Read More

Arch Dermatol Res 2022 Feb 24. Epub 2022 Feb 24.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Vacuoles, E1 enzyme, x-linked, autoinflammatory, and somatic mutation (VEXAS) syndrome is a recently described disease associated with high morbidity and mortality. VEXAS syndrome results from a somatic mutation affecting UBA1, a gene that codes for the E1 ubiquitin activating protein. Loss of UBA1 leads to a broad range of inflammatory conditions and a clinical course often refractive to therapy. Read More

Arch Dermatol Res 2022 Feb 24. Epub 2022 Feb 24.

Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, USA.

Physical activity has been associated with improved outcomes among cancer survivors of various malignancies; however, this topic is understudied among melanoma survivors. Our objective was to determine whether long-term melanoma survivors are less likely to meet American Cancer Society physical activity guidelines than non-melanoma population controls. We conducted a cross-sectional survey in 2015 to follow up participants from a case-control study of melanoma and population controls in Minnesota. Read More

Arch Dermatol Res 2022 Feb 22. Epub 2022 Feb 22.

Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Financial stress among skin cancer patients may limit treatment efficacy by forcing the postponement of care or decreasing adherence to dermatologist recommendations. Limited information is available quantifying the anxiety experienced by skin cancer patients from both healthcare and non-healthcare factors. Therefore, the present study sought to perform a retrospective cross-sectional review of the 2013-2018 cycles of the National Health Interview Survey (NHIS) to determine the prevalence, at-risk groups, and predictive factors of skin cancer patient financial stress. Read More

Arch Dermatol Res 2022 Feb 17. Epub 2022 Feb 17.

Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, 9th Floor, New York, NY, 10012, USA.

Arch Dermatol Res 2022 Feb 15. Epub 2022 Feb 15.

Veterans Affairs Medical Center, Brooklyn, NY, USA.

The data on skin substitute usage for managing Mohs micrographic surgery (MMS) wounds remain limited. This systematic review aimed to provide an overview of skin substitutes employed for MMS reconstruction, summarize clinical characteristics of patients undergoing skin substitute-based repair after MMS, and identify advantages and limitations of skin substitute implementation. A systematic review of Ovid MEDLINE, EMBASE, Cochrane Library, and Web of Science databases, from inception to April 7, 2021, identified all cases of MMS defects repaired using skin substitutes. Read More

Arch Dermatol Res 2022 Feb 11. Epub 2022 Feb 11.

Department of Dermatology, Yale School of Medicine, 15 York Street, New Haven, CT, USA.

Introduction: Eczema is a cause of significant morbidity in the US but few estimates of eczema prevalence in racially and ethnically diverse adult cohorts exist.

Methods: We performed a cross-sectional analysis of All of Us. Eczema cases were identified in EHR data using ICD-9-CM 691, 691. Read More

Arch Dermatol Res 2022 Mar 8;314(2):213-216. Epub 2022 Feb 8.

Department of Preventive Medicine - Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Micrographic dermatologic surgery (MDS) recently became a board-certified field within dermatology with the first board examination administered in October 2021. To be eligible, dermatologists must have completed a fellowship through the Accreditation Council for Graduate Medical Education (ACGME) or attest to active practice of Mohs micrographic surgery. Attestation of active practice is available from 2021-2025, after which, those sitting for the certifying examination must demonstrate completion of an ACGME-accredited fellowship. Read More

Arch Dermatol Res 2022 Feb 7. Epub 2022 Feb 7.

Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80, Campinas, Caixa Postal: 6121.CEP: 13083-862, São Paulo, Brazil.

Wound healing is a major problem in diabetic patients, and current treatments have been confronted with limited success. The present study examined the benefit of Wharton's jelly mesenchymal stem cells (WJ-MSCs) derived from the human umbilical cord (UC) in wound healing in diabetic rats. Thirty days after inducing diabetes, a circular excision was created in the skin of rats, and the treatments were performed for 21 days. Read More