8,614 results match your criteria Archives De Pediatrie[Journal]


Assessment of distance from skin surface to muscle for evaluation of the risk of inadvertent intramuscular insulin injection at potential injection sites among patients attending a tertiary care children's hospital in Sri Lanka-an observational study.

Arch Pediatr 2020 May 24. Epub 2020 May 24.

Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Colombo, Sri Lanka.

Background: Insulin therapy is essential for type 1 diabetes. While a reasonable glycemic control prevents complications, inadvertent intramuscular (IM) insulin injection results in hypoglycemia and fluctuations of blood glucose levels.

Objective: To assess the subcutaneous thickness (SCt) at the potential insulin injection sites, in order to determine the suitable needle length. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.008DOI Listing

How do parents of children with type 1 diabetes mellitus cope and how does this condition affect caregivers' mental health?

Arch Pediatr 2020 May 14. Epub 2020 May 14.

Department of Pediatric and Neonatology, Mongi-Slim Hospital, La Marsa, Tunisia.

Objective: To evaluate the impact that type 1 diabetes mellitus (T1DM) in children has on parents' mental health and parents' coping with this condition.

Methods: A cross-sectional study involving, at the outpatient examination, 41 caregivers of T1DM patients who had been diagnosed for at least 6 months. We evaluated the parents' coping strategies with the Brief COPE and their depressive and anxiety symptoms with the Hospital Anxiety and Depression Scale (HADS). Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.001DOI Listing

Management of 35 critically ill hyperammonemic neonates: Role of early administration of metabolite scavengers and continuous hemodialysis.

Arch Pediatr 2020 May 14. Epub 2020 May 14.

Pediatric Intensive Care Unit, Necker Enfants Malades University Hospital, AP-HP, 75015 Paris, France.

Neurological involvement is frequent in inherited metabolic disease of the intoxication type. Hyperammonemic coma related to these diseases may cause severe neurological sequelae. Early optimal treatment is mandatory combining metabolite scavengers (MS) and sometimes continuous veno-venous hemodialysis (CVVHD). Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.002DOI Listing

Aplasia cutis congenita of both knees: A new therapeutic strategy.

Arch Pediatr 2020 May 13. Epub 2020 May 13.

Department of Pediatric Orthopedic Surgery, Amiens University Medical Center and Jules Verne University of Picardie, 80054 Amiens cedex 1, France. Electronic address:

Aplasia cutis congenita is defined as the absence of all layers of the skin. The condition involves mainly the scalp but it can affect any area of skin on the body. A clear therapeutic strategy is not available. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.007DOI Listing

Assessment of general emergency medicine physicians' medical education regarding management of pediatric emergencies in western Normandy, France.

Arch Pediatr 2020 May 11. Epub 2020 May 11.

School of Medicine, University Caen Normandie, 14000 Caen, France; Department of Pediatrics, CHU de Caen, 14000 Caen, France; Pediatric Intensive Care Unit, CHU de Caen, avenue de la Côte de Nacre, 14000 Caen, France. Electronic address:

Objectives: General emergency medicine physicians sometimes have to deal with acute management of pediatric emergencies. The objectives of this study were to assess the pediatric medical education background of emergency physicians, how often they encounter pediatric emergencies, as well as the knowledge and organizational gaps regarding the management of children in general emergency departments.

Methods: A survey was conducted from March 25 to June 25, 2017, by emailing an anonymized questionnaire to all senior emergency physicians of the 22 general emergency departments of western Normandy public hospitals. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.005DOI Listing

Mortality of children aged 5-15 years in a tertiary care center in Yaoundé, Cameroon.

Arch Pediatr 2020 May 11. Epub 2020 May 11.

Faculty of medicine and biomedical sciences of the University of Yaoundé I, Yaoundé, Cameroon; Mother and Child Centre of the Chantal Biya Foundation of Yaoundé, Yaoundé, Cameroon.

Introduction: Although sub-Saharan Africa accounts for only 21% of the global population of children and adolescents aged 5-15 years, 55% of deaths among children in this age group occur in this region. This seems to be related to infectious diseases. We hypothesized that besides infectious diseases, in our context, a chronic underlying condition increases mortality. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.006DOI Listing

Antibiotic therapy in pediatric acute appendicitis: Compliance with local protocol to reduce antibiotic overuse.

Arch Pediatr 2020 May 11. Epub 2020 May 11.

Department of Pediatric Surgery, CHU d'Amiens-Picardie, Site Sud, 80054 Amiens, France. Electronic address:

Purpose: Acute appendicitis is one of the commonest surgical emergencies in pediatrics. Treatment usually consists of a combination of surgery and antibiotics. The present study was designed to assess compliance with our local antibiotic protocol and analyse the consequences of non-compliance. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.04.001DOI Listing

COVID-19 in pediatric patients: What the prehospital teams need to know.

Arch Pediatr 2020 May 6. Epub 2020 May 6.

Paris Fire Brigade Medical Emergency Department, 1, place Jules-Renard, 75017 Paris, France.

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http://dx.doi.org/10.1016/j.arcped.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200380PMC

Child with liver transplant recovers from COVID-19 infection. A case report.

Arch Pediatr 2020 May 6. Epub 2020 May 6.

Department of Pediatric Gastroenterology and Hepatology, Multidisciplinary pediatric, Aix Marseille University, La Timone Children Hospital, AP-HM, 13005 Marseille, France; Inserm, MMG, Aix Marseille Univ, 13005 Marseille, France.

We present the case of a 55-month-old girl who recovered from coronavirus disease 2019 (COVID-19) infection 5 months after undergoing liver transplantation; she had a co-infection with Epstein-Barr virus (EBV). To the best of our knowledge, this is the first case report of a COVID-19 infection in a pediatric patient with liver transplantation. Additionally, this is also the first report of confirmed co-infection between COVID-19 and EBV. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200359PMC

Response to: Neonatal transient hypophosphatemic hypercalciuric rickets in dizygous twins.

Arch Pediatr 2020 May 22;27(4):234. Epub 2020 Apr 22.

Service de néphrologie, rhumatologie et dermatologie pédiatriques, centre de référence des maladies rénales rares, centre de référence des maladies rares du calcium et du phosphore, hôpital Femme-Mère-Enfant, 69500 Bron, France.

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http://dx.doi.org/10.1016/j.arcped.2020.03.003DOI Listing

Case report of nutritional rickets in an infant following a vegan diet.

Arch Pediatr 2020 May 22;27(4):219-222. Epub 2020 Apr 22.

Paediatric Nutrition and Gastroenterology Department, Trousseau Hospital-AP-HP, Sorbonne Université, 26, avenue du Dr Arnold-Netter, 75012 Paris, France.

We report the case of a 13-month-old infant who was referred to the pediatric emergency department because of psychomotor regression with four bone fractures due to nutritional rickets. The reason was prolonged breastfeeding from a vegetarian mother followed by a vegan diet for the infant after weaning. Rickets is one of the many nutritional deficiencies that could affect infants fed vegan or vegetarian diets. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.008DOI Listing

Vegetarian diet in children and adolescents: A health benefit?

Arch Pediatr 2020 May 21;27(4):173-175. Epub 2020 Apr 21.

Société Française de Pédiatrie, hôpital Necker Carré Necker, 149, rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1016/j.arcped.2020.03.010DOI Listing

Negative influence of maternal smoking during pregnancy on infant outcomes.

Arch Pediatr 2020 May 21;27(4):189-195. Epub 2020 Apr 21.

Laboratoire Menarini, département médical, 1, rue du Jura, 94150 Rungis, France. Electronic address:

Background: According to the INPES 2014 health barometer, the prevalence of smoking in pregnant women in France is the highest in Europe : 17.8% of expectant mothers who smoke continue to do so during pregnancy. Several epidemiological studies have confirmed multiple risks for tobacco-exposed infants (low birth weight; digestive, respiratory, neurological, and psychological disorders; obesity; type 1 diabetes). Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.009DOI Listing

Investigation of injectable drug utilization in primary care: A focus on different age groups in pediatric population.

Arch Pediatr 2020 May 21;27(4):183-188. Epub 2020 Apr 21.

Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey. Electronic address:

Objective: The suitability of the injectables may vary across different age groups especially for children; therefore, knowledge on their usage patterns is critical in terms of rational pharmacotherapy. This study aimed to investigate pediatric injectable drug utilization in primary care with a focus on different age groups.

Method: By simple sampling method, 100 prescriptions that contained at least one injectable drug were randomly selected for each month of the year in 32 provinces of Turkey (n=38. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.012DOI Listing

Pediatric victims involved in urban fires in Paris and its suburbs: Epidemiology, prehospital care, and lessons learned.

Arch Pediatr 2020 May 21;27(4):196-201. Epub 2020 Apr 21.

Paris fire brigade medical emergency department, 1, place Jules-Renard 75017 Paris, France.

Aim: The literature includes few reports on the prehospital care of pediatric casualties of urban house fires. Here we aimed to describe the epidemiology of pediatric fire victims, focusing on their injuries, prehospital care, and survival.

Methods: This retrospective study included children under 15 years of age who were victims of urban house fires and who received care from prehospital medical teams. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.007DOI Listing

Practice survey on the use of vancomycin in pediatrics in the New Aquitaine region and guidelines of learned societies.

Arch Pediatr 2020 May 21;27(4):176-182. Epub 2020 Apr 21.

Néonatologie et soins intensifs néonatals, hôpital des enfants, CHU de Bordeaux, 33000 Bordeaux, France.

Introduction: Vancomycin is an old antibiotic whose use is still being debated today. The objective of this work was to establish an inventory of the use of vancomycin in the various pediatric and neonatal hospital services in the New Aquitaine region.

Materials And Methods: A declaratory practice survey was conducted in 49 pediatric and neonatal hospital units. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.013DOI Listing

Evaluation of a new training program to reassure primary school teachers about glucagon injection in children with type 1 diabetes during the 2017-2018 school year.

Arch Pediatr 2020 May 10;27(4):212-218. Epub 2020 Apr 10.

Department of Paediatrics, CHU de Caen, 14000 Caen, France.

Introduction: The prevalence of type 1 diabetes (T1D) in children is increasing. Adequate knowledge and skills of primary school staff are required to deal with children affected by T1D. We aimed to evaluate a video training program (VTP) to improve the level of confidence of teachers in administering intramuscular glucagon injection during severe hypoglycemia. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.02.002DOI Listing

Response to report of rickets in twins occurring after maternal bisphosphonate exposure.

Arch Pediatr 2020 May 9;27(4):233-234. Epub 2020 Apr 9.

Department of Pediatrics (Endocrinology), Yale University School of Medicine, P.O Box 208064, 06520-8064 New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arcped.2020.03.006DOI Listing

Tracheostomy, respiratory support, and developmental outcomes in neonates with severe lung diseases: Retrospective study in one center.

Arch Pediatr 2020 Apr 9. Epub 2020 Apr 9.

Pediatric Intensive Care Unit, CHU Sainte-Justine, Montreal, Canada; University of Montreal, Montreal, Canada. Electronic address:

Objectives: Pediatric tracheostomy has evolved significantly in the past few decades and the optimal timing to perform it in children with respiratory assistance is still debated. The objective of this study was to describe the indications, timing, complications, and outcomes of infants on respiratory support who had a tracheostomy in a tertiary pediatric intensive care unit (PICU).

Methods: All children younger than 18 months of corrected age requiring respiratory support for at least 1 week and who had a tracheostomy between January 2005 and December 2015 were included. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.011DOI Listing

Plasma lactate can improve the accuracy of the Pediatric Sequential Organ Failure Assessment Score for prediction of mortality in critically ill children: A pilot study.

Arch Pediatr 2020 May 8;27(4):206-211. Epub 2020 Apr 8.

Faculty of Medicine, Menoufia University, 32511 Menoufia, Egypt.

Background: Plasma lactate has been used to predict the prognosis of critically ill children, but mortality risk scores appear to be more appealing, particularly in resource-limited countries.

Objective: To assess the prognostic utility of lactate compared with the pediatric Sequential Organ Failure Assessment (pSOFA) score among the general pediatric intensive care unit (PICU) population.

Methods: This was a prospective observational study including 78 children admitted to a tertiary-level PICU. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.004DOI Listing

Mortality and morbidity of preterm neonates weighing less than 750g: A 2-year retrospective cohort study.

Arch Pediatr 2020 May 8;27(4):227-232. Epub 2020 Apr 8.

Service de Médecine et Réanimation néonatales, maternité Port-Royal, Hôpital Cochin-Broca-Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Université Paris V, 53, boulevard de l'Observatoire, 75014 Paris, France; INSERM, U1141, Hôpital Robert-Debré, 75019 Paris, Île-de-France, France.

Background: The rate of premature births in France is 6% and is increasing, as is the rate of extremely premature births. Morbidity and mortality rates in this population remain high despite significant medical progress. We aimed to evaluate the morbidity and mortality rate in preterm neonates weighing<750g and to evaluate their outcome at 2 years' corrected age (CA). Read More

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http://dx.doi.org/10.1016/j.arcped.2020.02.003DOI Listing

Satisfaction of mothers regarding human milk donation.

Arch Pediatr 2020 May 8;27(4):202-205. Epub 2020 Apr 8.

Unité de gastroentérologie et nutrition pédiatriques, hôpital des Enfants, CHU de Bordeaux, 3306 Bordeaux cedex, France.

In France, human milk banks are in charge of the collection, analysis, processing, and distribution of human milk to neonatology centers for preterm infants. Knowledge of what motivates mothers to donate their milk could lead to better communication regarding human milk donation. A satisfaction survey was conducted among mothers who were donating their milk to a human milk bank. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.03.005DOI Listing

Will pediatric medicine sink below the waterline? Chronicle of an abuse foretold.

Authors:
I Claudet

Arch Pediatr 2020 Apr;27(3):119-121

Pediatric emergency department, Children's hospital, CHU Toulouse, 330, Great Britain Avenue, TSA 70034, 31059 Toulouse, France; UMR 1027, Inserm, Paul Sabatier-Toulouse III University, Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.arcped.2020.03.002DOI Listing

COVID-19 virus and children: What do we know?

Arch Pediatr 2020 04;27(3):117-118

UMR VITROME, service de santé des armées, IRD, IHU-méditerranée-infection, Aix-Marseille university, AP-HM, 13385 Marseille cedex 05, France.

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http://dx.doi.org/10.1016/j.arcped.2020.03.001DOI Listing

Management of eosinophilic esophagitis in children according to atopic status: A retrospective cohort in northeast of France.

Arch Pediatr 2020 Apr 16;27(3):122-127. Epub 2020 Mar 16.

EA 3450 DevAH, département de physiologie, faculté de médecine, université de Lorraine, Vandoeuvre-les-Nancy, France; Unité d'allergologie pédiatrique, hôpital d'enfants, CHRU de Nancy, rue du Morvan, 54011 Vandœuvre-Lès-Nancy, France; UMR 6249 chrono-environnement, CNRS et université de Franche-Comté, Besançon, France. Electronic address:

Introduction: Most children with eosinophilic esophagitis (EoE) are atopic, but the impact of atopy on the remission and development of EoE is still unclear. The aim of our study was to determine the impact of atopy on remission of EoE and to describe allergy tests and the choice of treatment for a cohort of EoE children in France.

Methods: All children diagnosed with EoE between January 2013 and June 2018 in the five pediatric centers in the northeast of France were included. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.02.001DOI Listing

Smoke inhalation injury in a 2-year-old domestic fire victim.

Arch Pediatr 2020 May 16;27(4):223-226. Epub 2020 Mar 16.

Pediatric Intensive Care Unit, Raymond-Poincaré Hospital, AP-HP, 92380 Garches, France.

Smoke inhalation injury is common in victims of domestic fires, among whom children are the most vulnerable. Cyanide poisoning may occur in addition to carbon monoxide poisoning and is challenging to diagnose. In France, the recommended antidotes are hydroxocobalamin for cyanide and hyperbaric oxygen for carbon monoxide. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.008DOI Listing

CFTR gene variants, epidemiology and molecular pathology.

Arch Pediatr 2020 Feb;27 Suppl 1:eS8-eS12

Laboratoire de Génétique Moléculaire, CHU de Montpellier, Montpellier, France; EA7402 Laboratoire de Génétique de Maladies Rares, Institut Universitaire de Recherche Clinique, Université de Montpellier, Montpellier, France.. Electronic address:

Pathogenic variants of the CFTR gene are responsible for a broad phenotypic spectrum characterized by malfunction of some exocrine tissues, with an autosomal recessive mode of inheritance. More than 2,000 variants, distributed throughout the CFTR gene, have been identified, with different effects on the gene and protein expression and function. Genotype-phenotype correlation studies have associated severe variants with a typical multi-organ form of cystic fibrosis, while mild variants are involved in monosymptomatic or adult-onset diseases, called CFTR-related disorders. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30044-0DOI Listing
February 2020

Conclusion and Prospects: Genetics of cystic fibrosis - an agenda for the next ten years.

Authors:
C Castellani

Arch Pediatr 2020 02;27 Suppl 1:eS45-eS47

Cystic Fibrosis Centre, IRCCS Istituto Giannina Gaslini, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S0929-693X(20)30051-8DOI Listing
February 2020

Genomically-guided therapies: A new era for cystic fibrosis.

Authors:
I Fajac E Girodon

Arch Pediatr 2020 Feb;27 Suppl 1:eS41-eS44

APHP, Centre-Université de Paris, Hôpital Cochin, Laboratoire de Génétique et Biologie Moléculaires, Paris, France.

Since the cloning of the CFTR gene 30 years ago, research aiming at understanding how CFTR mutations translate to abnormal synthesis or function of the CFTR protein has opened the way to genomically-guided therapy to improve CFTR function. A CFTR potentiator to enhance CFTR channel function has been approved in 2012 for specific and quite rare mutations. Subsequently, combinations of a corrector to increase CFTR expression at the cell membrane, plus a potentiator, have been approved for patients homozygous for the p. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30050-6DOI Listing
February 2020

Genetics of cystic fibrosis: Basics.

Authors:
C Férec V Scotet

Arch Pediatr 2020 Feb;27 Suppl 1:eS4-eS7

Inserm, Univ Brest, EFS, UMR 1078, GGB, F-29200 Brest, France.

Cystic fibrosis (CF) is an autosomal recessive genetic disorder whose responsible gene - the CFTR gene - was discovered 30 years ago by a positional cloning strategy. This gene, which encodes a chloride channel, contains more than 2,000 mutations including a major one (p.Phe508del). Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30043-9DOI Listing
February 2020

Newborn screening for CF in France: An exemplary national experience.

Arch Pediatr 2020 Feb;27 Suppl 1:eS35-eS40

Société Française de Dépistage Néonatal, France; CRCM Hopital Necker Enfants Malades, Paris.

Newborn screening (NBS) for cystic fibrosis (CF) was implemented throughout France since 2002, with a 3-tiered strategy consisting in an immunoreactive trypsinogen (IRT) measurement at day-3, a search for the most common mutations responsible for CF when the IRT value is above the cut-off level, and, if necessary, a safetynet retesting of IRT at day-21. Coordination and follow-up are ensured at the national level and NBS is carried out through a regional organization involving NBS centers, biochemical and molecular genetics laboratories. Sweat testing and comprehensive mutation gene analysis are then performed according to a defined algorithm. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30049-XDOI Listing
February 2020

Genetic counseling for cystic fibrosis: A basic model with new challenges.

Arch Pediatr 2020 Feb;27 Suppl 1:eS30-eS34

Génétique Médicale, CHR Clemenceau, CHU de Caen, Avenue Côte de Nacre, France.

While the goals of genetic counseling for cystic fibrosis - delivering relevant information on the risk of recurrence and nondirectional support of couples at risk in their reproductive choices - have not changed fundamentally, the practice has evolved considerably in the last decade, growing more complex to face new challenges but also proving more effective. Many factors have contributed to this evolution: technical progress in the exploration of the genome (new generation sequencing) and in reproductive medicine, but also societal developments promoting access to genetic information and the professionalization of genetic counselors in France. The prospect of expanded pre-conception screening of at-risk couples makes genetic counselors major actors not only in medical care centers, but also in modern society by contributing to genetic education among citizens. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30048-8DOI Listing
February 2020

Genetic diagnosis in practice: From cystic fibrosis to CFTR-related disorders.

Arch Pediatr 2020 Feb;27 Suppl 1:eS25-eS29

ERN-Lung CF network; Université de Paris, INSERM U 1016, Institut Cochin, Paris, France; National Reference Center for Cystic Fibrosis, Hôpital Cochin, Service de Pneumologie, AP-HP, Paris, France. Electronic address:

Cystic fibrosis (CF) is a channelopathy caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. Diagnosis of CF has long relied on a combination of clinical (including gastrointestinal and/or respiratory) symptoms and elevated sweat chloride concentration. After cloning of the CFTR gene in 1989, genetic analysis progressively became an important aspect of diagnosis. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30047-6DOI Listing
February 2020

Preface.

Authors:
E Girodon I Fajac

Arch Pediatr 2020 Feb;27 Suppl 1:eS2-eS3

AP-HP, Hôpital Cochin, Service de Physiologie et Explorations Fonctionnelles, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/S0929-693X(20)30042-7DOI Listing
February 2020

Current and future diagnosis of cystic fibrosis: Performance and limitations.

Arch Pediatr 2020 Feb;27 Suppl 1:eS19-eS24

Laboratoires de Biochimie Générale & du Centre Régional du Dépistage Néonatal Ile-de-France, Hôpital Necker-Enfants Malades, APHP. Centre Université de Paris, Paris; Centre de Ressources et de Compétences de la Mucoviscidose, Hôpital Necker-Enfants Malades, AP-HP. Centre Université de Paris, Paris; Institut Necker Enfants Malades/INSERM U1151, Mucoviscidose et autres maladies épithéliales respiratoires par défaut de repliement protéique, Université Paris Descartes, Paris.

Cystic fibrosis (CF) is the most frequent genetic disorder in the Caucasian population benefiting from systematic newborn screening tests. It is also the most frequent indication of prenatal and preimplantation genetic diagnosis for a single gene disorder. During the past thirty years, thanks in part to the evolution of diagnostic techniques, our knowledge on CFTR genetics and pathophysiological mechanisms involved in CF have significantly improved. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30046-4DOI Listing
February 2020

Variant classifications, databases and genotype-phenotype correlations.

Authors:
C Raynal H Corvol

Arch Pediatr 2020 Feb;27 Suppl 1:eS13-eS18

Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, Paris, France; AP-HP, Hôpital Trousseau, Service de Pneumologie Pédiatrique, Paris, France.

Because CFTR gene studies now represent one of the most frequent genetic analyses routinely performed worldwide, the number of rare CFTR variants identified in various clinical situations, regularly increases. To provide appropriate diagnosis and prognosis to CF patients as well as appropriate genetic counseling to families, the clinical impact and the phenotypic spectrum of variants identified by diagnostic techniques need to be characterized. Three complementary locus specific databases, called CFTR1, CFTR2 and CFTR-France were developed to address these issues. Read More

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http://dx.doi.org/10.1016/S0929-693X(20)30045-2DOI Listing
February 2020

Editorial.

Authors:
I Durieu

Arch Pediatr 2020 Feb;27 Suppl 1:eS1

Hospices Civils de Lyon, centre Hospitalier Lyon-Sud, centre de référence mucoviscidose (site constitutif), service de médecine interne. 69495 Pierre-Bénite Cédex. France; Université de Lyon, Université Claude Bernard Lyon1; Animatrice de la filière MUCO-CFTR.

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http://dx.doi.org/10.1016/S0929-693X(20)30041-5DOI Listing
February 2020

Mutations in NBAS and SCYL1, genetic causes of recurrent liver failure in children: Three case reports and a literature review.

Arch Pediatr 2020 Apr 4;27(3):155-159. Epub 2020 Mar 4.

Department of pediatric gastroenterology and hepatology, multidisciplinary pediatric, La-Timone children hospital, Aix-Marseille university, Assistance Publique-Hôpitaux de Marseille, 13385 Marseille cedex 05, France.

Acute liver failure (ALF) in childhood is a life-threatening emergency. ALF is often caused by drug toxicity, autoimmune hepatitis, inherited metabolic diseases, and infections. However, despite thorough investigations, a cause cannot be determined in approximately 50% of cases. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.003DOI Listing

Carbon monoxide poisoning in children: It should be measured to be improved.

Arch Pediatr 2020 Apr 2;27(3):170-171. Epub 2020 Mar 2.

Sistema d'Emergències Mèdiques (SEM), Barcelona, España.

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http://dx.doi.org/10.1016/j.arcped.2020.01.007DOI Listing

Pediatric ocular trauma: Characteristics and outcomes among a French cohort (2007-2016).

Arch Pediatr 2020 Apr 29;27(3):128-134. Epub 2020 Feb 29.

Pediatric Emergency Department, Children's Hospital, CHU of Toulouse, TSA 70034, 330, Great-Britain avenue 31059 Toulouse cedex 9, France; UMR 1027, INSERM, Paul-Sabatier University, UPS, 31059 Toulouse cedex 9, France. Electronic address:

Pediatric ocular trauma is a major cause of acquired monocular blindness. Post-traumatic visual impairment can lead to significant handicap. In France, recent data on the epidemiology of pediatric ocular trauma are lacking. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.002DOI Listing

Outcome and management of newborns with congenital cytomegalovirus infection.

Arch Pediatr 2020 Apr 29;27(3):160-165. Epub 2020 Feb 29.

Service de réanimation néonatale, CHU Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

Congenital cytomegalovirus (CMV) infection is the most common non-genetic cause of hearing loss and neurological disorder in children. Its overall prevalence is approximately 0.5% in Europe. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.006DOI Listing

Changes in nutrient absorption in children and adolescents caused by fructans, especially fructooligosaccharides and inulin.

Arch Pediatr 2020 Apr 29;27(3):166-169. Epub 2020 Feb 29.

Universidade Federal do Ceará, Fortaleza, Ceará, Brasil; Universidade Estadual do Ceará, Fortaleza, Ceará, Brasil.

Introduction: Fructans, such as inulin and fructooligosaccharides (FOS), have several effects on human health owing to their prebiotic character, including anti-microbial and anti-cancer effects, and to their influence on the absorption of minerals, which is very important in childhood and adolescence.

Objective: Our aim was to review the role of some fructans in the absorption of vitamins and minerals in children and adolescents.

Methods: We conducted a narrative review of the absorption of nutrients with fructans. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.004DOI Listing

Non accidental repeated lithium poisoning in a child: The role of hair analysis.

Arch Pediatr 2020 Apr 14;27(3):152-154. Epub 2020 Feb 14.

Pediatrics unit, CHU de Timone enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France. Electronic address:

Non accidental intoxication due to child abuse is rare and its frequency is likely underestimated because it is difficult to diagnose. Here, we report a case of voluntary repeated exposure to lithium in an infant, for whom the clinical manifestations were convulsions. Toxicological analysis was very helpful for documenting lithium exposure during the assumed period of time. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.01.005DOI Listing

Erratum to « Breastfeeding and early childhood caries. Review of the literature, recommendations, and prevention » [Arch. Pediatr. 26 (8) (2019) 497–503].

Arch Pediatr 2020 04 5;27(3):172. Epub 2020 Feb 5.

Département de santé publique odontologie, faculté d'odontologie de Lorraine, université de Lorraine, 7, avenue de la Forêt-de-Haye, BP 20199, 54505 Vandoeuvre-lès-Nancy, France.

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http://dx.doi.org/10.1016/j.arcped.2020.01.001DOI Listing

Relationship between pediatric adiposity and cardiovascular risk factors in Saudi children and adolescents.

Arch Pediatr 2020 Apr 23;27(3):135-139. Epub 2020 Jan 23.

Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: The etiology of childhood obesity is growing at alarming rates in developed and developing countries. The aim of the present study was to investigate the prevalence of cardiovascular risk factors (hypertension, dyslipidemia, and hyperglycemia) in a sample of Saudi children and to assess their association with different measures of body adiposity.

Methods: A cross-sectional study was conducted of 200 Saudi children, who were randomly selected from the pediatric clinics at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.12.007DOI Listing

Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.

Arch Pediatr 2020 Feb 18;27(2):66-71. Epub 2020 Jan 18.

Réanimation et surveillance continue médico-chirurgicales pédiatrique, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.

Objectives: The purpose of this study was to describe and compare the initial management, including clinical/biological investigation and treatment, of new-onset seizures and status epilepticus (SE) in children versus seizures and SE in those with known epilepsy.

Methods: This was a retrospective, single-center, observational study conducted in an urban pediatric hospital in Paris. All patients, aged from 1 month to 18 years, admitted to the pediatric intensive care unit, the high-dependency care unit, and those who required hospitalization in the short-term unit of the emergency department between January 1 and December 31, 2014 for seizures and/or SE were included. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.12.001DOI Listing
February 2020

Breast milk feeding of preterm infants in France. What have we learned from the EPIPAGE studies?

Authors:
A Mitha V Pierrat

Arch Pediatr 2020 Feb 18;27(2):63-65. Epub 2020 Jan 18.

Inserm U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics-Paris University, DHU Risks in Pregnancy, Paris Descartes University, 53, avenue de l'Observatoire, 75014 Paris, France; Department of Neonatal Medicine, Jeanne-de-Flandre Hospital, UHC Lille, 59000 Lille, France.

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http://dx.doi.org/10.1016/j.arcped.2019.12.004DOI Listing
February 2020

Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency.

Arch Pediatr 2020 Apr 16;27(3):140-145. Epub 2020 Jan 16.

Department of Pediatric Endocrinology, İzmir Katip Çelebi University Hospital, Güney Mahallesi, 1140/1. Sk. No:1, 35180 İzmir, Turkey.

Objectives: The prevalence of obesity among children and adolescents has been rapidly increasing in recent years. Obese individuals are at risk of vitamin D deficiency. The aim of this study was to investigate the relationship between vitamin D deficiency and anthropometric measurements, cardiovascular risk factors, and glucose homeostasis in obese children. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.12.005DOI Listing

Late infective endocarditis after transcatheter tricuspid valve-in-valve implantation: A pediatric case report.

Arch Pediatr 2020 Feb 16;27(2):107-109. Epub 2020 Jan 16.

Department of Pediatric and Congenital Cardiology, M3C Regional Reference Center, Montpellier University Hospital, PhyMedExp, Inserm, CNRS, University of Montpellier, 34295 Montpellier, France.

In patients with congenital heart diseases, new procedures, such as transcatheter valve replacement, have been associated with a non-negligible incidence of infective endocarditis (IE): up to 4% patient-year IE incidence. Prosthetic IE after percutaneous tricuspid valve replacement (PTVR) has been scarcely reported. We report the first pediatric case of IE after percutaneous tricuspid Melody™ valve-in-valve implantation in a boy who was diagnosed with Eisenmenger syndrome, related to patent ductus arteriosus. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.12.002DOI Listing
February 2020

Potassium disorders in pediatric emergency department: Clinical spectrum and management.

Arch Pediatr 2020 Apr 16;27(3):146-151. Epub 2020 Jan 16.

Emergency Department, Hospital Universitaire des Enfants Reine Fabiola (HUDERF), Université Libre de Bruxelles (ULB), Bruxelles, Belgium; Departments of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles (ULB), Bruxelles, Belgium. Electronic address:

Introduction: Potassium abnormalities are frequent in intensive care but their incidence in the emergency department is unknown.

Aim: We describe the spectrum of potassium abnormalities in our tertiary-level pediatric emergency department.

Methods: Retrospective case-control study of all the patients admitted to a single-center tertiary emergency department over a 2. Read More

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http://dx.doi.org/10.1016/j.arcped.2019.12.003DOI Listing