17,633 results match your criteria Archive Of Applied Mechanics[Journal]


Yottixel - An Image Search Engine for Large Archives of Histopathology Whole Slide Images.

Med Image Anal 2020 Jun 24;65:101757. Epub 2020 Jun 24.

University of Pittsburgh Medical Center, Department of Pathology, PA, USA.

With the emergence of digital pathology, searching for similar images in large archives has gained considerable attention. Image retrieval can provide pathologists with unprecedented access to the evidence embodied in already diagnosed and treated cases from the past. This paper proposes a search engine specialized for digital pathology, called Yottixel, a portmanteau for "one yotta pixel," alluding to the big-data nature of histopathology images. Read More

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http://dx.doi.org/10.1016/j.media.2020.101757DOI Listing

Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma.

Oral Oncol 2020 Jun 30;110:104877. Epub 2020 Jun 30.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Purpose: To identify whether radiomic features from pre-treatment computed tomography (CT) scans can predict molecular differences between head and neck squamous cell carcinoma (HNSCC) using The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA).

Methods: 77 patients from the TCIA with HNSCC had imaging suitable for analysis. Radiomic features were extracted and unsupervised consensus clustering was performed to identify subtypes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104877DOI Listing

Plexiform Myofibroblastoma: Clinicopathologic Analysis of 36 Cases of a Distinctive Benign Tumor of Soft Tissue Affecting Mainly Children and Young Adults.

Am J Surg Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, Brigham and Women's Hospital.

The spectrum of benign superficial fibroblastic/myofibroblastic tumors continues to expand and includes entities such as plexiform fibrohistiocytic tumor, dermatomyofibroma and fibroblastic connective tissue nevus. Here, we describe a seemingly distinctive group of lesions which we have labeled "plexiform myofibroblastoma" (PM). PM is a rare superficial mesenchymal tumor of fibroblastic/myofibroblastic lineage that predominantly occurs in children and young adults. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001534DOI Listing

Influences for Gender Disparity in Academic Family Medicine in North American Medical Schools.

Cureus 2020 May 30;12(5):e8368. Epub 2020 May 30.

Radiology, Vancouver General Hospital, Vancouver, CAN.

Background Women physicians continue to comprise the minority of leadership roles in Academic Family Medicine (AFM) faculty across North American medical schools. Our study quantified the current state of gender disparity by analyzing academic position, leadership ranking, and research productivity. Methods We generated a database for 6,746 AFM faculty members. Read More

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http://dx.doi.org/10.7759/cureus.8368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326302PMC

The Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose (1886-1947): its formation, rise and demise.

Authors:
P J Bradley

J Laryngol Otol 2020 Jul 3:1-5. Epub 2020 Jul 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, UK.

Background: The Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose existed in Nottingham for over 60 years, but there is little knowledge or documentation regarding its existence.

Methods: The following resources were searched to find out more about the hospital: the Nottinghamshire Archives; Manuscripts and Special Collections at the University of Nottingham Libraries; and Nottingham Central Library. Information was also obtained from the founders' relatives. Read More

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http://dx.doi.org/10.1017/S0022215120001322DOI Listing

[Men in Closed Venerological Wards of the GDR illustrated by Examples of Berlin, Dresden and Erfurt].

Gesundheitswesen 2020 Jul 1. Epub 2020 Jul 1.

Institut für Geschichte, Theorie und Ethik der Medizin, Universität Ulm, Ulm.

Objectives: While numerous research results are available on the treatment of women in closed venereological wards in the GDR, hardly anything is known about the forced admissions of men to these wards. The aim of this study was to analyse construction of the wards, the admission and maintenance in the wards as well as the extent of the compulsory admissions of men.

Methods: Unprinted sources were researched in the Federal Archive and State Archive Berlin and in the municipal archives of Erfurt and Zwickau and analyzed using a historically critical method. Read More

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http://dx.doi.org/10.1055/a-1186-0075DOI Listing

Consequences of cryopreservation in diverse natural isolates of Saccharomyces cerevisiae.

Genome Biol Evol 2020 Jul 1. Epub 2020 Jul 1.

Department of Integrative Biology, Oregon State University, 3029 Cordley Hall, 2701 SW Campus Way, Corvallis, OR.

Experimental evolution allows the observation of change over time as laboratory populations evolve in response to novel, controlled environments. Microbial evolution experiments take advantage of cryopreservation to archive experimental populations in glycerol media, creating a frozen, living "fossil" record. Prior research with Escherichia coli has shown that cryopreservation conditions can affect cell viability and that allele frequencies across the genome can change in response to a freeze-thaw event. Read More

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http://dx.doi.org/10.1093/gbe/evaa121DOI Listing

From the archive.

Authors:

Nature 2019 Jul 2. Epub 2019 Jul 2.

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http://dx.doi.org/10.1038/d41586-019-02045-1DOI Listing

The Great Acceleration of fragrances and PAHs archived in an ice core from Elbrus, Caucasus.

Sci Rep 2020 Jun 30;10(1):10661. Epub 2020 Jun 30.

Institute of Polar Sciences (ISP-CNR), Via Torino 155, Venezia-Mestre, 30172, Venice, Italy.

The Great Acceleration of the anthropogenic impact on the Earth system is marked by the ubiquitous distribution of anthropogenic materials throughout the global environment, including technofossils, radionuclides and the exponential increases of methane and carbon dioxide concentrations. However, personal care products as direct tracers of human domestic habits are often overlooked. Here, we present the first research combining fragrances, as novel personal care products, and polycyclic aromatic hydrocarbons (PAHs) as combustion and industrial markers, across the onset of the Great Acceleration in the Elbrus, Caucasus, ice core. Read More

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http://dx.doi.org/10.1038/s41598-020-67642-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327048PMC

Cerebral schistosomiasis: MRI features with pathological correlation.

Acta Radiol 2020 Jun 30:284185120934475. Epub 2020 Jun 30.

Department of Radiology, Sichuan University West China Hospital, Chengdu, Sichuan, PR China.

Background: Neuroschistosomiasis is not commonly encountered and is probably underrecognized. We hope these findings can help clinicians and radiologists to raise awareness of this disabling disorder.

Purpose: To demonstrate the magnetic resonance imaging (MRI) findings of cerebral schistosomiasis and correlate it with pathological findings. Read More

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http://dx.doi.org/10.1177/0284185120934475DOI Listing

Living with COVID-19-triggered pseudoscience and conspiracies.

Int J Public Health 2020 Jun 29. Epub 2020 Jun 29.

Department of Biology, College of Natural and Computational Science, Kotebe Metropolitan University, Addis Ababa, Ethiopia.

Objective: This piece of work proposes a way for the wise management of pseudoscience and conspiracy theories.

Methods: This work encompassed a review of relevant literature and synthesized the critical thoughts on the proper management of pseudoscience and conspiracy theories.

Result: The coronavirus disease 2019 (COVID-19) overwhelmingly challenges the competency of the digital generation. Read More

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http://dx.doi.org/10.1007/s00038-020-01412-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323368PMC

Melanoma and non-melanoma skin cancer among patients who attended at King Khalid University Hospital in Riyadh, Saudi Arabia from 2007 - 2018.

Saudi Med J 2020 Jul;41(7):709-714

Division of Plastic Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the prevalence of melanoma and non-melanoma skin cancer for patients attended King Khalid University Hospital, Riyadh, Saudi Arabia. We are also assessing the most common category of skin cancer to be encountered among those patients. Methods: The authors conducted a retrospective study including all patients (Saudi and non-Saudi) who attended King Khalid University Hospital (KKUH) at the period of (2007-2018). Read More

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http://dx.doi.org/10.15537/smj.2020.7.25138DOI Listing

Role of platelets in neonatal necrotizing enterocolitis.

Authors:
Akhil Maheshwari

Pediatr Res 2020 Jun 29. Epub 2020 Jun 29.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and is a leading cause of morbidity and mortality in infants born between 23 and 28 weeks of gestation. Fifty to 95% of all infants with NEC develop thrombocytopenia (platelet counts <150 × 10/L) within 24-72 h of receiving this diagnosis. In many patients, thrombocytopenia is severe and is treated with one or more platelet transfusions. Read More

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http://dx.doi.org/10.1038/s41390-020-1038-8DOI Listing

Predictors of filing claims and receiving compensation in malignant mesothelioma patients.

Health Policy 2020 Jun 10. Epub 2020 Jun 10.

Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers' Compensation Authority (INAIL), Via Stefano Gradi, 55, 00143 Rome, Italy.

Although the predominant occupation origin of mesothelioma is well known, determinant factors involved in filing compensation are scarcely investigated. A linkage between incident mesothelioma cases collected by Italian mesothelioma register (ReNaM) and compensation claims and assignment by Italian national insurance Institute (INAIL) has been conducted for cases diagnosed in the period 2010-2015 and occupational exposure to asbestos. Logistic regression models and decision tree models have been used to identify demographic, diagnostic and anamnestic factors significant for filing and receiving compensation. Read More

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http://dx.doi.org/10.1016/j.healthpol.2020.06.005DOI Listing

Radiogenomics correlation between MR imaging features and mRNA-based subtypes in lower-grade glioma.

BMC Neurol 2020 Jun 29;20(1):259. Epub 2020 Jun 29.

Department of Medical Imaging, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou City, 510623, PR China.

Background: To investigate associations between lower-grade glioma (LGG) mRNA-based subtypes (R1-R4) and MR features.

Methods: mRNA-based subtyping was obtained from the LGG dataset in The Cancer Genome Atlas (TCGA). We identified matching patients (n = 145) in The Cancer Imaging Archive (TCIA) who underwent MR imaging. Read More

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http://dx.doi.org/10.1186/s12883-020-01838-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322922PMC

[Anniversary of Academician of the Russian Academy of Sciences, Professor Alexander G. Chuchalin].

Ter Arkh 2020 Apr 27;92(3):33926. Epub 2020 Apr 27.

Therapeutic Archive Magazine.

Alexander Grigorievich Chuchalin is a world-famous scientist, an outstanding representative of modern Russian medical science and practical health care, the founder of a whole area in Russian medicine - pulmonology. Thanks to his activities, his unique developments in Russia and abroad, millions of people with lung diseases have been saved. The whole domestic and world medical community congratulates Alexander Grigoryevich on his eightieth birthday! Read More

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[Anniversary of the honored scientist professor Sergey Nikolaevich Tereshchenko].

Ter Arkh 2020 Jun 5;92(5):34605. Epub 2020 Jun 5.

Journal "Therapeutic archive".

April 23, 2020 marks the 60th anniversary of a prominent national cardiologist Sergey Nikolaevich Tereshchenko. Read More

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Spatial Analysis of Growing Follicles in the Human Ovary to Inform Tissue Engineering Strategies.

Tissue Eng Part A 2020 Jun 26. Epub 2020 Jun 26.

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Cancer survivorship has increased considerably, but common cancer treatments may threaten female reproductive health and fertility. In females, standard fertility preservation techniques include egg and embryo banking and ovarian tissue cryopreservation, but these methods are not suitable for all individuals. Emerging fertility preservation technologies include follicle growth and ovarian bioprosthetics. Read More

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http://dx.doi.org/10.1089/ten.tea.2020.0051DOI Listing

Resolving atmospheric mercury loading and source trends from isotopic records of remote North American lake sediments.

Environ Sci Technol 2020 Jun 27. Epub 2020 Jun 27.

The strongest evidence for anthropogenic alterations to the global mercury (Hg) cycle comes from historical records of mercury deposition preserved in lake sediments. Hg isotopes have added a new dimension to these sedimentary archives, promising additional insights into Hg source apportionment and biogeochemical processing. Presently, most interpretations of historical changes are constrained to a small number of locally contaminated ecosystems. Read More

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http://dx.doi.org/10.1021/acs.est.0c00579DOI Listing

The Emerging Adults Gambling Survey: study protocol.

Authors:
Heather Wardle

Wellcome Open Res 2020 26;5:102. Epub 2020 May 26.

Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, 15-17 Tavistock Place, London, WC1H9SH, UK.

The Emerging Adults Gambling Survey is a longitudinal survey of young adults aged 16-24 living in Great Britain. It aims to explore a range of gambling behaviours and harms among young adults and examine how this changes over time. It is part of a broader project funded by Wellcome into the gambling behaviours of young people and its relationship with technological change. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15969.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312251PMC

Decline of "the American Dream"? Outlook toward the Future across Three Generations of Midwest Families.

Soc Forces 2020 Jun 15;98(4):1403-1435. Epub 2019 Nov 15.

University of Michigan-Dearborn.

Expansion of higher education and long-term economic growth have fostered high aspirations among adolescents. Recently, however, deteriorating labor force opportunities, particularly since the "Great Recession," and rising inequality have challenged the "American Dream." To assess how parental and adolescent outlooks have evolved over time, we examine shifts in future orientations across three generations of Midwest American families. Read More

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http://dx.doi.org/10.1093/sf/soz130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299541PMC

The Rock of Gibraltar: The Value of Mentorship in the Early Years (Dr. Virginia Apgar and Dr. Ralph Waters).

J Anesth Hist 2020 Jun 9;6(2):49-53. Epub 2019 Sep 9.

Department of Anesthesiology, University of Mississippi, Oxford, MS.

Behind every successful physician there are mentors to light the path. Ralph Waters, founder of the anesthesiology residency at the University of Wisconsin-Madison, was an instrumental part of Virginia Apgar's success; his support of her education and promotion of her professional endeavors proved to shape the medical powerhouse that Apgar would become. In this article, we learn about the professional and personal relationship between Waters and Apgar through personal correspondence from the Ralph Waters Collection at University of Wisconsin Archives, scientific publications, and meeting records. Read More

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http://dx.doi.org/10.1016/j.janh.2019.08.005DOI Listing

Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Multiple kernel learning for integrative consensus clustering of 'omic datasets.

Bioinformatics 2020 Jun 27. Epub 2020 Jun 27.

MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, U.K.

Motivation: Diverse applications - particularly in tumour subtyping - have demonstrated the importance of integrative clustering techniques for combining information from multiple data sources. Cluster Of Clusters Analysis (COCA) is one such approach that has been widely applied in the context of tumour subtyping. However, the properties of COCA have never been systematically explored, and its robustness to the inclusion of noisy datasets is unclear. Read More

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http://dx.doi.org/10.1093/bioinformatics/btaa593DOI Listing

Gynecologic Risk Mitigation Considerations for Long-Duration Spaceflight.

Aerosp Med Hum Perform 2020 Jul;91(7):543-564

As NASA and its international partners, as well as the commercial spaceflight industry, prepare for missions of increasing duration and venturing outside of low-Earth orbit, mitigation of medical risk is of high priority. Gynecologic considerations constitute one facet of medical risk for female astronauts. This manuscript will review the preflight, in-flight, and postflight clinical evaluation, management, and prevention considerations for reducing gynecologic and reproductive risks in female astronauts. Read More

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http://dx.doi.org/10.3357/AMHP.5538.2020DOI Listing

Absence of BRAFV600E Immunohistochemical Expression in Sporadic Odontogenic Keratocyst, Syndromic Odontogenic Keratocyst and Orthokeratinized Odontogenic Cyst.

J Oral Pathol Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, 400008, India.

Background: Odontogenic keratocyst (OKC) is a unique developmental odontogenic cyst that has the potential to behave aggressively, and is associated with the nevoid basal cell carcinoma syndrome. Orthokeratinized odontogenic cyst (OOC) is a distinct, uncommon odontogenic cyst. It significantly differs from OKC not only in its epithelial lining but also in proliferating kinetics, clinical, immunohistochemical and biological behaviour. Read More

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http://dx.doi.org/10.1111/jop.13081DOI Listing

Open modeling and exchange (OMEX) metadata specification version 1.0.

J Integr Bioinform 2020 Jun 25. Epub 2020 Jun 25.

Humboldt University Berlin, Berlin, Germany.

A standardized approach to annotating computational biomedical models and their associated files can facilitate model reuse and reproducibility among research groups, enhance search and retrieval of models and data, and enable semantic comparisons between models. Motivated by these potential benefits and guided by consensus across the COmputational Modeling in BIology NEtwork (COMBINE) community, we have developed a specification for encoding annotations in Open Modeling and EXchange (OMEX)-formatted archives. Distributing modeling projects within these archives is a best practice established by COMBINE, and the OMEX metadata specification presented here provides a harmonized, community-driven approach for annotating a variety of standardized model and data representation formats within an archive. Read More

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http://dx.doi.org/10.1515/jib-2020-0020DOI Listing

Correction to: Analysis of clinical features of RPE adenoma.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 25. Epub 2020 Jun 25.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

In the original version of our paper entitled Analysis of clinical features of RPE adenoma published in Graefe's Archive for Clinical and Experimental Ophthalmology. Read More

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http://dx.doi.org/10.1007/s00417-020-04816-3DOI Listing

Activity and Health During the SARS-CoV2 Pandemic (ASAP): Study Protocol for a Multi-National Network Trial.

Front Med (Lausanne) 2020 5;7:302. Epub 2020 Jun 5.

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, United States.

The worldwide spread of the novel coronavirus (SARS-CoV2) has prompted numerous countries to restrict public life. Related measures, such as limits on social gatherings, business closures, or lockdowns, are expected to considerably reduce the individual opportunities to move outside the home. As physical activity (PA) and sport participation significantly contribute to health, this study has two objectives. Read More

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http://dx.doi.org/10.3389/fmed.2020.00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291162PMC

Global trends, local harms: availability of fentanyl-type drugs on the dark web and accidental overdoses in Ohio.

Comput Math Organ Theory 2019 Mar 25;25(1):48-59. Epub 2018 Oct 25.

Department of Computer Science and Engineering, Kno.e.sis Center, Wright State University, Dayton, OH, USA.

As America's opioid crisis has become an "epidemic of epidemics," Ohio has been identified as one of the high burden states regarding fentanyl-related overdose mortality. This study aims to examine changes in the availability of fentanyl, fentanyl analogs, and other non-pharmaceutical opioids on cryptomarkets and assess relationship with the trends in unintentional overdoses in Ohio to provide timely information for epidemiologic surveillance. Cryptomarket data were collected at two distinct periods of time: (1) Agora data covered June 2014-September 2015 and were obtained from Grams archive; (2) Dream Market data from March-April 2018 were extracted using a dedicated crawler. Read More

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http://dx.doi.org/10.1007/s10588-018-09283-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311101PMC

[Albrecht von Graefe and the beginning of modern ophthalmology : Graefe year 2020].

Ophthalmologe 2020 Jun 23. Epub 2020 Jun 23.

Universitäts-Augenklinik, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Deutschland.

After almost 4000 years of history, ophthalmology became independent between 1850 and 1900. The decisive founder of modern ophthalmology was Albrecht von Graefe (1828-1870), who founded both his archive (1854), which still exists today and is named after him, and the German Ophthalmological Society (1857). There are still numerous Graefe sites today, especially in Berlin. Read More

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http://dx.doi.org/10.1007/s00347-020-01139-wDOI Listing

Dataset of de novo assembly and functional annotation of the transcriptome during germination and initial growth of seedlings of "camu-camu".

Data Brief 2020 Aug 11;31:105834. Epub 2020 Jun 11.

Unidad Especializada de Biotecnología, Centro de Investigaciones de Recursos Naturales de la Amazonía (CIRNA), Universidad Nacional de la Amazonia Peruana (UNAP), Psje. Los Paujiles S/N, San Juan Bautista, Loreto, 16000, Perú.

"camu-camu" is a native shrub of the Amazon that is commonly found in areas that are flooded for three to four months during the annual hydrological cycle. This plant species is exceptional for its capacity to biosynthesize and accumulate important quantities of a variety of health-promoting phytochemicals, especially vitamin C [1], yet few genomic resources are available [2]. Here we provide the dataset of a de novo assembly and functional annotation of the transcriptome from a pool of samples obtained from seeds during the germination process and seedlings during the initial growth (until one month after germination). Read More

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http://dx.doi.org/10.1016/j.dib.2020.105834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305401PMC

[Food in contemporary Spain through NO-DO newsreel.]

Rev Esp Salud Publica 2020 Jun 24;94. Epub 2020 Jun 24.

Cátedra Balmis de Vacunología. Universidad de Alicante. Alicante. España.

The NO-DO, a weekly projection of the Franco regime, created as a diffusion service of obligatory exhibition in Spanish cinemas, constitutes the greatest audiovisual historical background for the contemporary history of Spain in the 20th century. The analysis and study of these newsreels and documentaries illustrate parallel to the political and socioeconomic evolution of that time, how the process of food and nutritional transition took place. The main objective of this work was to analyse and reflect on the image that these newsreels and documentaries offered to the Spanish population on the field of nutrition and the development of the different tendencies in the diet of this period. Read More

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BRG1 Is Dispensable for Sertoli Cell Development and Functions in Mice.

Int J Mol Sci 2020 Jun 19;21(12). Epub 2020 Jun 19.

Department of Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824, USA.

Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. BRG1 (Brahma related gene 1) is a catalytic subunit of the mammalian SWI/SNF chromatin remodeling complex and participates in transcriptional regulation. The present study aimed to define the functions of BRG1 in mouse Sertoli cells during mouse spermatogenesis. Read More

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http://dx.doi.org/10.3390/ijms21124358DOI Listing

[That daily trickle of death: Infant mortality and the dawn of pediatric medicine in the province of Santiago, Chile, 1870-1913].

Salud Colect 2020 May 16;16:e2727. Epub 2020 May 16.

Doctor en Historia. Profesor Adjunto e Investigador, Centro de Estudios Históricos, Universidad Bernardo O'Higgins; Santiago, Chile.

This article deals with the problem of infant mortality in Santiago, Chile, and the development of pediatric medicine during the second half of the nineteenth century and the beginning of the twentieth century. Emphasis is placed on the specialists who contributed to organizing the knowledge and practices that structured their professional field. In order to pursue the objective and systematize this new medical field, our analysis suggests the decisive role of the establishment of the Faculty of Medicine and the appearance of coursework dedicated specifically to childhood diseases. Read More

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http://dx.doi.org/10.18294/sc.2020.2727DOI Listing

RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes.

BMC Genomics 2020 Jun 22;21(1):417. Epub 2020 Jun 22.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Multipotent mesenchymal stromal cells (MSCs) can be isolated from numerous tissues and are attractive candidates for therapeutic clinical applications due to their immunomodulatory and pro-regenerative capacity. Although the minimum criteria for defining MSCs have been defined, their characteristics are known to vary depending on their tissue of origin.

Results: We isolated and characterized human MSCs from three different bones (ilium (I-MSCs), maxilla (Mx-MSCs) and mandible (Md-MSCs)) and proceeded with next generation RNA-sequencing. Read More

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http://dx.doi.org/10.1186/s12864-020-06825-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310078PMC
June 2020
3.986 Impact Factor

Quality of Otology and Neurotology Research in Otolaryngology Journals.

Otol Neurotol 2020 Jun 19. Epub 2020 Jun 19.

Otolaryngology-Head & Neck Surgery.

Objective: To identify trends in the quality of otology studies published in general otolaryngology journals over a 20-year period.

Study Design: Retrospective analysis.

Methods: Otologic and neurotologic papers from 1997, 2007, and 2017 were identified in the three general otolaryngology journals with the highest Eigenfactor scores: the Laryngoscope, European Archives of Otorhinolaryngology, and Otolaryngology-Head and Neck Surgery. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002731DOI Listing

Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents: A Systematic Review.

Ann Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Duke University School of Medicine and Durham Veterans Affairs Health Care System, Durham, North Carolina (J.W.W., K.M.G.).

Background: The risk for nephrogenic systemic fibrosis (NSF) after exposure to newer versus older gadolinium-based contrast agents (GBCAs) remains unclear.

Purpose: To synthesize evidence about NSF risk with newer versus older GBCAs across the spectrum of kidney function.

Data Sources: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science for English-language references from inception to 5 March 2020. Read More

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http://dx.doi.org/10.7326/M20-0299DOI Listing

Data on genome resequencing of pigmented and non-pigmented Malaysian rice varieties.

Data Brief 2020 Aug 3;31:105806. Epub 2020 Jun 3.

Biotechnology and Nanotechnology Research Centre, Malaysian Agricultural Research & Development Institute (MARDI), 43400 Serdang, Selangor, Malaysia.

The genomics and genetic data of pigmented and non-pigmented Malaysian rice varieties are still limited. Hence, we performed the genome resequencing of two black rice varieties (Bali, Pulut Hitam 9), two red rice varieties (MRM16, MRQ100) and two white rice varieties (MR297 and MRQ76) using Illumina HiSeq 4000 platform with 30x sequencing coverage. We aimed to identify and annotate single nucleotide polymorphisms (SNPs) from the genome of these four pigmented and two non-pigmented rice varieties. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298397PMC

Transcriptomic dataset of exposed to an imidazo[1,2-][1,2,4,5]tetrazine.

Data Brief 2020 Aug 2;31:105805. Epub 2020 Jun 2.

Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow, 119333, Russia.

Deciphering the mechanism of action of novel anti-tuberculosis compounds is a key step in the drug development process. We have previously described a number of imidazo[1,2-][1,2,4,5]tetrazines with a promising activity on [1]. These compounds had predicted activity as serine‑threonine protein kinase inhibitors, however spontaneous drug resistant (formerly ) revealed only the mycobacterial mechanism of resistance to imidazo[1,2-][1,2,4,5]tetrazines: mutations in gene lead to overexpression of the operon in , thus providing resistance to imidazo[1,2-][1,2,4,5]tetrazines via enhanced efflux [2]. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298395PMC

Functional and Structural Analysis of Predicted Proteins Obtained from Minisatellite 33.15-Tagged Transcript pAKT-45 Variants.

Biomed Res Int 2020 23;2020:2562950. Epub 2020 May 23.

Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.

The spermatozoa are transcriptionally dormant entities which have been recognized to be an archive of mRNA, coding for a variety of functionally crucial cellular proteins. This significant repository of mRNA is predicted to be associated with early embryogenesis and postfertilization. The mRNA transcripts which are tagged with minisatellites have been involved in the regulation of the gene functions as well as their organization. Read More

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http://dx.doi.org/10.1155/2020/2562950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273396PMC

A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).

F1000Res 2020 22;9. Epub 2020 Apr 22.

Institute of Biotechnology of the Czech Academy of Sciences, Vestec, CZ-25250, Czech Republic.

Structural bioinformatics provides the scientific methods and tools to analyse, archive, validate, and present the biomolecular structure data generated by the structural biology community. It also provides an important link with the genomics community, as structural bioinformaticians also use the extensive sequence data to predict protein structures and their functional sites. A very broad and active community of structural bioinformaticians exists across Europe, and 3D-Bioinfo will establish formal platforms to address their needs and better integrate their activities and initiatives. Read More

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http://dx.doi.org/10.12688/f1000research.20559.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284151PMC

A Clinicopathologic Analysis of 135 Cases of Cemento-Osseous Dysplasia: To Operate or Not to Operate?

J Stomatol Oral Maxillofac Surg 2020 Jun 18. Epub 2020 Jun 18.

Associate Professor, Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey. Electronic address:

Purpose: The aim of this retrospective study was to investigate the characteristics of cemento-osseous dysplasia (COD) lesions for devising a clinical algorithm to help management decisions, specifically discussing the need for a possible surgical intervention versus solely follow-up.

Materials And Methods: One hundred thirty five subjects were thus identified having previously diagnosed and treated for COD from the archives of the pathology in between 2005-2015. These were then re-evaluated. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.06.002DOI Listing

[From Chinese Medical Association Medical History Museum to the Shanghai Museum of Traditional Chinese Medicine: commemoration of the 130th anniversary of the birthday of modern medical historian Wang Jimin].

Authors:
L L Wang L Y Chen

Zhonghua Yi Shi Za Zhi 2019 Nov;49(6):343-349

Institute of Science, Technology and Humanities, SHUTCM, Shanghai 201203, China.

The Shanghai Museum of Traditional Chinese Medicine, formerly known as the Chinese Medical Association Medical History Museum, is the first professional medical history museum in China. Wang Jimin is the main planner and founder of the Medical History Museum of the Chinese Medical Association and served as the first curator. In 1951, the Chinese Medical Association moved to Beijing, and the Medical History Museum stayed in Shanghai. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0255-7053.2019.06.003DOI Listing
November 2019

Mapping of atmospheric heavy metal deposition in Guangzhou city, southern China using archived bryophytes.

Environ Pollut 2020 Jun 11;265(Pt B):114998. Epub 2020 Jun 11.

School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China. Electronic address:

Atmospheric heavy metal contamination is becoming a serious threat to environmental and human health in Chinese megacities. This study evaluated the concentrations of arsenic (As), cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn) and Pb isotopic compositions in herbarium and native bryophytes collected from Guangzhou from 1932 to 2018. Relatively low mean metal concentrations were measured for bryophytes collected in the 1930s. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114998DOI Listing

Formalin-preserved zooplankton are not reliable for historical reconstructions of methylmercury bioaccumulation.

Sci Total Environ 2020 May 30;738:139803. Epub 2020 May 30.

Department of Marine Sciences, University of Connecticut, 1080 Shennecossett Rd, Groton, CT 06340, United States; Billion Oyster Project, Governors Island, 10 South St., Slip 7, New York, NY 10004, United States.

Time-series measurements of methylmercury (MeHg) concentrations in short-lived planktic animals, such as copepods, could allow for an evaluation of mercury (Hg) inputs and transferability to organisms in marine environments. If reliable, MeHg measurements in formalin-preserved marine animals could offer insights into past environmental MeHg levels. In the present study, we examined whether the amount of MeHg changed over time in formalin-preserved copepods for two species, Acartia tonsa, and Temora longicornis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139803DOI Listing

Corrigendum to "Interaction of central obesity and sarcopenia on nutritional status in the community-dwelling older people" [Archives of Gerontology and Geriatrics 87 (March-April) (2020) 104003].

Arch Gerontol Geriatr 2020 Jun 17:104153. Epub 2020 Jun 17.

Department of Family Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.archger.2020.104153DOI Listing

ETS transcription factor ESE-1/Elf3 is an independent prognostic factor of survival in HRHER2 breast cancer patients.

Breast Cancer Res Treat 2020 Aug 19;182(3):601-612. Epub 2020 Jun 19.

Cancer Biology Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Purpose: The ETS transcription factor ESE-1 has been shown to be important in HER2 breast cancer and ESE-1 mRNA expression has been shown to associate with prognostic outcomes in the HER2 subtype, as well as in ER, HER2 luminal B patients. However, the clinical significance of ESE-1 protein expression remains unknown. The purpose of the current exploratory study is to evaluate the prognostic value of ESE-1 protein expression in molecular breast cancer subtypes with special emphasis on hormone receptor positive HER2(HR HER2) and the HER2 positive (HER2-only) breast cancer patients. Read More

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http://dx.doi.org/10.1007/s10549-020-05734-yDOI Listing

The Combination of Low Skeletal Muscle Mass and High Tumor Interleukin-6 Associates with Decreased Survival in Clear Cell Renal Cell Carcinoma.

Cancers (Basel) 2020 Jun 17;12(6). Epub 2020 Jun 17.

Departments of Surgery, IU School of Medicine, Indianapolis, IN 46202, USA.

Clear cell renal carcinoma (ccRCC) is frequently associated with cachexia which is itself associated with decreased survival and quality of life. We examined relationships among body phenotype, tumor gene expression, and survival. Demographic, clinical, computed tomography (CT) scans and tumor RNASeq for 217 ccRCC patients were acquired from the Cancer Imaging Archive and The Cancer Genome Atlas (TCGA). Read More

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http://dx.doi.org/10.3390/cancers12061605DOI Listing