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Arch Appl Mech 2022 Feb 3;92(2):447-459. Epub 2021 Jun 3.

Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, USA.

Transport of solute across the arterial wall is a process driven by both convection and diffusion. In disease, the elastic fibers in the arterial wall are disrupted and lead to altered fluid and mass transport kinetics. A computational mixture model was used to numerically match previously published data of fluid and solute permeation experiments in groups of mouse arteries with genetic (knockout of fibulin-5) or chemical (treatment with elastase) disruption of elastic fibers. Read More

Arch Appl Mech 2022 Feb 7;92(2):491-511. Epub 2021 Jan 7.

Department of Mechanical Engineering, Columbia University, New York, NY 10027.

The primary aim of this study is to establish the theoretical foundations for a solid-fluid biphasic mixture domain that can accommodate inertial effects and a viscous interstitial fluid, which can interface with a dynamic viscous fluid domain. Most mixture formulations consist of constituents that are either all intrinsically incompressible or compressible, thereby introducing inherent limitations. In particular, mixtures with intrinsically incompressible constituents can only model wave propagation in the porous solid matrix, whereas those with compressible constituents require internal variables, and related evolution equations, to distinguish the compressibility of the solid and fluid under hydrostatic pressure. Read More

Arch Appl Mech 2021 20;91(6):2497-2511. Epub 2021 Feb 20.

Faculty of Engineering, Helwan University, P.O. Box 11718, Mataria, Cairo, Egypt.

Most recently, the whole world is struggling against the virulent pandemic COVID-19. Due to the unbounded global spread of the disease, having biosensors with high performance such as high sensitivity and accuracy is of utmost importance. In this paper, the effects of various parameters on the behaviors of micro-biosensors are investigated in order to enhance their performance. Read More