Search Our Scientific Publications & Authors

Cytopathology 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, All India Institute of medical sciences (AIIMS), New Delhi, India.

Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children and young adults but can be found in any age group. Diagnosis of LCH is often difficult and can be delayed because of its rarity. The present study highlights the cytomorphological features in a large cohort of cases. Read More

Int Orthod 2019 Apr 20. Epub 2019 Apr 20.

Indiana University School Dentistry, Department of Orthodontics and Oral Facial Genetics, Indianapolis, IN, USA; Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Hamdan Bin Mohammed College of Dental Medicine, Department of Orthodontic, Dubai, United Arab Emirates; Al-Azhar University, Faculty of Dental Medicine, Department of Orthodontics, Cairo, Egypt. Electronic address:

Objectives: The purpose of this study was to investigate differences in the thickness of the labial bone overlying the maxillary and mandibular incisors in class I, II, and III skeletal classifications using three-dimensional cone-beam computed tomographs (CBCT) technology.

Methods: Pretreatment CBCTs of 54 Caucasian subjects (44 males, 10 females) were collected from the archives of a graduate orthodontic clinic. The subjects were divided into three groups based on their skeletal classification. Read More

BMC Bioinformatics 2019 Apr 23;20(1):207. Epub 2019 Apr 23.

Department of Entomology and Center for Comparative Genomics, Institute for Biodiversity Science and Sustainability, California Academy of Sciences, 55 Music Concourse Dr., San Francisco, USA.

Background: Research over the last 10 years highlights the increasing importance of hybridization between species as a major force structuring the evolution of genomes and potentially providing raw material for adaptation by natural and/or sexual selection. Fueled by research in a few model systems where phenotypic hybrids are easily identified, research into hybridization and introgression (the flow of genes between species) has exploded with the advent of whole-genome sequencing and emerging methods to detect the signature of hybridization at the whole-genome or chromosome level. Amongst these are a general class of methods that utilize patterns of single-nucleotide polymorphisms (SNPs) across a tree as markers of hybridization. Read More

Sci Rep 2019 Apr 23;9(1):6381. Epub 2019 Apr 23.

Philips Research, Hamburg, Germany.

The increased availability of labeled X-ray image archives (e.g. ChestX-ray14 dataset) has triggered a growing interest in deep learning techniques. Read More

CNS Spectr 2019 Apr 23:1-4. Epub 2019 Apr 23.

President of Brandenburg Medical School - Theodor Fontane,Campus Neuruppin, Germany and Senior Professor of Health Services Research at Witten/Herdecke University,Germany.

The cause of the early death of Wolfgang Amadeus Mozart (1756-1791) at the age of 35 has been the source of much discussion in the medical community. Investigators attributed to Mozart nearly 150 different medical diagnoses. However, the neurosurgical aspect of the early death of Mozart has yet to be well-analyzed, and this subject was investigated herein. Read More

Eur Stroke J 2017 Mar 4;2(1):31-36. Epub 2016 Nov 4.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.

Introduction: Antiplatelet therapy is routinely prescribed early after ischaemic stroke. Many patients will already be taking antiplatelet therapy and it is unknown whether these patients should continue the same antiplatelet treatment or switch to a different regimen.

Methods: We selected patients with ischaemic stroke from the Virtual International Stroke Trials Archive database who were prescribed antiplatelets both before and after their stroke and who had detailed records of adverse events after stroke. Read More

Eur Stroke J 2016 Dec 26;1(4):302-309. Epub 2016 Aug 26.

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.

Introduction: Few proven therapies for intracerebral haemorrhage exist. Preliminary observational evidence suggests that sulphonylurea and metformin may be protective in ischaemic stroke. We assessed the association of pre-intracerebral haemorrhage sulphonylurea and metformin use on outcome in diabetic patients. Read More

Stroke 2019 May;50(5):1136-1139

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, United Kingdom (A.W., J.D., D.A.D.).

Background and Purpose- Individual markers of cerebral small vessel disease and cerebral atrophy explain a small proportion of variance in vascular risk factors and cognitive function. Combining these markers into a single measure of neurovascular and neurodegenerative disease may be more powerful. We assessed this using data contained in the Virtual International Stroke Trials Archive - Prevention sub-archive. Read More

AEM Educ Train 2019 Apr 19;3(2):172-178. Epub 2019 Feb 19.

Department of Emergency Medicine The George Washington University Washington DC.

Objectives: Competency assessment is a key component of point-of-care ultrasound (POCUS) training. The purpose of this study was to design a smartphone-based standardized direct observation tool (SDOT) and to compare a faculty-observed competency assessment at the bedside with a blinded reference standard assessment in the quality assurance (QA) review of ultrasound images.

Methods: In this prospective, observational study, an SDOT was created using SurveyMonkey containing specific scoring and evaluation items based on the Council of Emergency Medicine Residency-Academy of Emergency Ultrasound: Consensus Document for the Emergency Ultrasound Milestone Project. Read More

Perspect Clin Res 2019 Apr-Jun;10(2):79-83

Department of Clinical Pharmacology, SRM MCH and RC, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu, India.

Aim: In this retrospective cross-sectional study, we sought to evaluate if the published randomized controlled trials (RCTs) reported in the year 2017 among the Indian medical journals (IMJs) complied with the Consolidated Standards of Reporting Trials (CONSORT) guidelines and identify domains where reporting could be improved.

Methods: A literature search was performed using PubMed and Google Scholar to identify all the IMJs that published RCTs in the year 2017. In the archives of the identified journals, the number of published RCTs was identified and the full text was obtained. Read More

Ann Anat 2019 Apr 18. Epub 2019 Apr 18.

Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00, Olomouc, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00, Olomouc, Czech Republic. Electronic address:

Introduction: In this study we detail the effect of different fixation agents and the duration of storage has on the immunohistochemical staining positivity of samples of archival embryonic and fetal tissues.

Materials And Methods: The samples were stained by indirect two-step immunohistochemistry (IHC) method for Ki-67, cyclin A and β-actin.

Results: Irrespective of the length of tissue archiving, tissue fixation with 10% neutral buffered formalin had better IHC intensity results in all cases when compared to methacarn-fixed tissues. Read More

Am J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

College of Medicine, Central Michigan University, Mount Pleasant, MI, USA. Electronic address:

Background: Rural communities experience significant barriers to quality healthcare, including disparities in medical care following acute myocardial infarctions (AMI). This study sought to determine if the population density of the county where Medicare patients were hospitalized following AMI predicted short-term outcomes and to quantify longitudinal changes in hospital performance on quality of care metrics.

Methods: Hospital-level data was queried from the 2012 and 2018 Centers for Medicare & Medicaid Services archives. Read More

Science 2019 Apr 18. Epub 2019 Apr 18.

Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.

Earthquakes follow a well-known power-law size relation, with smaller events occurring much more often than larger events. Earthquake catalogs are thus dominated by small earthquakes, yet still missing a much larger number of even smaller events caused by signal fidelity issues. To overcome these limitations, we applied a template matching detection technique to the entire waveform archive of the regional seismic network in southern California. Read More

Phys Med 2019 Apr 29;60:91-99. Epub 2019 Mar 29.

S.C. Fisica Sanitaria, A.O.U. Città della Salute e della Scienza, Corso Bramante 88/90, 10126 Turin, Italy. Electronic address:

Purpose: This study investigated the benefits of implementing a cluster analysis technique to extract relevant information from a computed tomography (CT) dose registry archive.

Methods: A CT patient dose database consisting of about 12,000 examinations and 29,000 single scans collected from three CT systems was interrogated. The database was divided into six subsets according to the equipment and the reference phantoms in the definition of the dose indicators. Read More

Ecotoxicol Environ Saf 2019 Apr 15;178:79-85. Epub 2019 Apr 15.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China. Electronic address:

Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of aridity and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.

Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients operated for ESCC who had no history of workplace exposure to silica dust. Read More

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Oral and Maxillofacial Surgery Attending, University of Florida College of Dentistry, Gainesville, FL.

Purpose: To describe and discuss the demographic and clinical features of oral melanomas, which are relatively rare but deadly neoplasms, and list the criteria for their diagnosis to increase early detection.

Materials And Methods: An institutional review board-approved retrospective search of oral melanomas was performed in the archives of the University of Florida Oral and Maxillofacial Pathology Biopsy Service (Gainesville, FL) from 2015 through 2018. Exclusion criteria included cases with inconclusive diagnosis, skin involvement, and missing clinical data or slide material. Read More

BMJ Open Ophthalmol 2019 28;4(1):e000193. Epub 2019 Feb 28.

Department of Pathology, Section for Eye Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Objective: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern.

Methods And Analysis: Cases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Read More

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Kirchhoff-Institute for Physics, Heidelberg University, 69120 Heidelberg, Germany.

Radiometric dating with Ar covers a unique time span and offers key advances in interpreting environmental archives of the last millennium. Although this tracer has been acknowledged for decades, studies so far have been limited by the low abundance and radioactivity, thus requiring huge sample sizes. Atom trap trace analysis, an application of techniques from quantum physics such as laser cooling and trapping, allows us to reduce the sample volume by several orders of magnitude compared with conventional techniques. Read More

J Am Coll Surg 2019 Apr 14. Epub 2019 Apr 14.

Department of Surgery, University of Arizona, Tucson, AZ.

Background: Overall incidence of CC is decreasing, however with increasing early-onset colon cancer (EOCC <50 y.o.). Read More

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

2 KEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.

Purpose: Antimicrobial resistance (AMR) is of increasing global concern, threatening to undermine recent progress in reducing child and neonatal mortality. Repurposing older antimicrobials is a prominent strategy to combat multidrug-resistant sepsis. A potential agent is fosfomycin, however, there is scarce data regarding its in vitro activity and pharmacokinetics in the paediatric population. Read More

Nature 2019 Apr;568(7752):323

BMC Bioinformatics 2019 Apr 15;20(1):184. Epub 2019 Apr 15.

Department of Microbiology & Plant Pathology and Institute for Integrative Genome Biology, University of California-Riverside, Riverside, CA, 92521, USA.

Background: Inexpensive high-throughput DNA sequencing has democratized access to genetic information for most organisms so that research utilizing a genome or transcriptome of an organism is not limited to model systems. However, the quality of the assemblies of sampled genomes can vary greatly which hampers utility for comparisons and meaningful interpretation. The uncertainty of the completeness of a given genome sequence can limit feasibility of asserting patterns of high rates of gene loss reported in many lineages. Read More

Wellcome Open Res 2019 8;4:48. Epub 2019 Mar 8.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK.

We aimed to investigate whether infection with high-risk (HR) types of human papilloma virus (HPV) or HPV-associated cervical disease were associated with preterm birth (<37 weeks gestation). In a sub-group of younger women who were eligible for the HPV vaccine, we aimed to determine whether prior vaccination against the specific HPV-types, HPV-16 and -18 modified preterm birth risk. This was a data-linkage study, which linked HPV-associated viral and pathological information (from the Scottish HPV Archive) from women aged 16-45 years to routinely collected NHS maternity- and hospital-admission records from 1999-2015. Read More

Sci Rep 2019 Apr 12;9(1):6012. Epub 2019 Apr 12.

Statistics Online Computational Resource (SOCR), Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, USA.

The UK Biobank is a rich national health resource that provides enormous opportunities for international researchers to examine, model, and analyze census-like multisource healthcare data. The archive presents several challenges related to aggregation and harmonization of complex data elements, feature heterogeneity and salience, and health analytics. Using 7,614 imaging, clinical, and phenotypic features of 9,914 subjects we performed deep computed phenotyping using unsupervised clustering and derived two distinct sub-cohorts. Read More

Sci Total Environ 2019 Apr 1;672:657-668. Epub 2019 Apr 1.

Centro Universitário Regional Este, CURE-Rocha, Universidad de la República, Ruta 9 y Ruta 15 s/n, Uruguay; Programa de Pós-Graduação em Oceanografia Física, Química e Geológica, Instituto de Oceanografia, Universidade Federal do Rio Grande, Av. Itália, km 8, Cx.P. 474, 96201-900 Rio Grande, RS, Brazil.

Lakes are important paleoenvironmental archives retaining abundant information due to their typical high sedimentation rates and susceptibility to environmental changes. Here, we scrutinize the organic matter (OM) composition, origin and preservation state in surface sediments from five lakes in a remote, warming-sensitive, and poorly explored region partially covered by the retreating Collins Glacier in King George Island (Antarctica), the Fildes Peninsula. Lipid biomarkers of terrestrial origin (i. Read More

J Pediatr Hematol Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pathology, Children's Mercy Hospital/University of Missouri Kansas City School of Medicine, Kansas City, MO.

Neuroblastoma (NB) in children older than 10 years is rare. We reviewed our archives for patients with NB aged 10 to 18 years and summarized their clinicopathologic/genetic records. Of 96 patients, 4 patients were identified in this age group. Read More

J Pathol Inform 2019 21;10. Epub 2019 Feb 21.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Accurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the limitations of WSI, as it is most often used, is the lack of a multiplanar focusing option. Read More

Viruses 2019 Apr 9;11(4). Epub 2019 Apr 9.

Unité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13005 Marseille, France.

Massilia virus (MASV) is a phlebovirus isolated from in various regions of southwestern Europe. It is closely related to human pathogens such as Toscana virus and sandfly fever Naples virus. The natural cycle of phleboviruses is poorly understood. Read More

Monaldi Arch Chest Dis 2019 Mar 29;89(1). Epub 2019 Mar 29.

ASST Grande Ospedale Metropolitano Niguarda, Department of Cardiothoracic and Vascular Surgery.

Associazione Riabilitatori dell'Insufficienza Respiratoria (ARIR) is pleased to announce a new editorial project by joining the Monaldi Archives of Chest Disease journal. Read More

Monaldi Arch Chest Dis 2019 Mar 29;89(1). Epub 2019 Mar 29.

ICS Maugeri.

The Editors: Antonio Spanevello, Bruno Balbi Another year has passed, and we would like to thank and recognize all of the many members who have contributed to the editorial process and content of Monaldi during 2018. Our submissions are increasing, citations for our papers are rising, and recognition of the journal is broadening. Not settled for focusing on past goings-on only, we now direct our efforts toward building an even greater impact. Read More

Indian J Orthop 2019 Mar-Apr;53(2):276-281

IRCAD-AITS, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.

Background: Intramedullary (IM) or extramedullary (EM) mechanical guides are used as alignment tools during total knee arthroplasty (TKA) surgery. The EM guide is less invasive; however, the IM mechanical guide is the preferred option since it has shown superior outcomes in several studies. Picture archive and communication system (PACS) images, if available, are extensively used for preoperative planning and intraoperative guidance. Read More

J Biol Regul Homeost Agents 2019 Jan-Feb;33(Suppl 1 [integer]):55-59

Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

Socket preservation is a surgical procedure whose aim is to limit the physiological resorption of the alveolar ridge that occurs after a dental extraction, in order to have sufficient bone to perform an implant placement. 16 articles regarding socket preservation procedures were identified through scientific archives and analysed. The biological rationale, the graft materials and the predictive factors are identified to help the clinicians in their practice. Read More

J Biol Regul Homeost Agents 2019 Jan-Feb;33(Suppl 1 [integer]):49-53

Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

TGuided bone regeneration (GBR) is a surgical procedure whose purpose is to obtain, new bone, new cementum and a new periodontal attachment around a periodontally compromised tooth. In this work, an overview of the literature was performed to analyze the state of the art concerning GBR in order to draw useful conclusions for clinical practice. Twenty-nine articles regarding GBR procedures were identified through scientific archives and analyzed. Read More

J Biol Regul Homeost Agents 2019 Jan-Feb;33(Suppl 1 [integer]):43-47

Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

The first option in the rehabilitation of the posterior atrophic maxilla is the sinus lift. The aim of this study is to highlight the characteristics that a sinus lift should have to maximize the subsequent implant survival rate. 33 systematic reviews regarding sinus lift procedures, implants success and survival rates were identified through scientific archives and analysed. Read More

Sci Total Environ 2019 Apr 2;672:438-455. Epub 2019 Apr 2.

Laboratory for the Analysis of Natural and Synthetic Environmental Toxicants, Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada. Electronic address:

"-Omics" is a powerful screening method with applications in molecular biology, toxicology, wildlife biology, natural product discovery, and many other fields. Genomics, proteomics, metabolomics, and lipidomics are common examples included under the "-omics" umbrella. This screening method uses combinations of untargeted, semi-targeted, and targeted analyses paired with data mining to facilitate researchers' understanding of the genome, proteins, and small organic molecules in biological systems. Read More

J Cosmet Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, Imam Muhammad ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Objective: This review is primarily focusing on the legitimate concern about bacterial contamination after reuse of stored filling syringes and its associated risk of infections.

Methods: A comprehensive literature review was done through searching the PubMed, Medline, Google Scholar, and ResearchGate without setting a time limit. The following search terms were used soft tissue filler, hyaluronic acid, or calcium hydroxylapatite AND sterility, safety, retouch, touch up, or reuse. Read More

Dtsch Arztebl Int 2019 Mar;116(9):149-158

Background: 10-20% of hospitalized patients develop acute kidney injury (AKI)/acute renal failure during their hospital stay. The mortality of nosocomial AKI is approximately 30%.

Methods: This review is based on relevant publications retrieved by a search in multiple databases (PubMed and Uptodate), archives, and pertinent medical journals. Read More

Arh Hig Rada Toksikol 2019 Mar;70(1):1-2

Institute for Medical Research and Occupational Health, Zagreb, Croatia;

This year we turn 70! Lucky for journals, they don't get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you - our readers and authors - where we see Archives in the years to come. Read More

Gulf J Oncolog 2019 Jan;1(29):31-38

Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK.

Objective: We present an approach to obtain accurate and complete data on the last known vital status, and the date of last known vital status of all Kuwaiti cancer patients. These data are essential for robust estimation of population-based cancer survival.

Methods: Government-issued Civil ID numbers (IDs) of patients registered during 2000-2013 were obtained from the Kuwait Cancer Registry. Read More

Environ Int 2019 Apr 4;127:371-380. Epub 2019 Apr 4.

School of Life Sciences, Jianghan University, Wuhan 430056, China.

A global survey was performed with 122 aquatic metagenomic DNA datasets (92 lake water and 30 seawater) obtained from the Sequence Read Archive (SRA). Antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) were derived from the dataset sequences via bioinformatic analysis. The relative abundances of ARGs and MRGs in lake samples were in the ranges ND (not detected)-1. Read More

Nature 2019 Apr;568(7752):E11

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

In this Review, the year of publication of reference 54 should be 2005, not 2015. In Box 2, "1982: GenBank ( https://www.ncbi. Read More

Br J Hist Sci 2019 Apr 5:1-19. Epub 2019 Apr 5.

*University of Leicester.

This article addresses the issue of professionalization in the life sciences during the second half of the nineteenth century through a survey of British entomological periodicals. It is generally accepted that this period saw the rise of professional practitioners and the emergence of biology (as opposed to the older mode of natural history). However, recent scholarship has increasingly shown that this narrative elides the more complex processes at work in shaping scientific communities from the 1850s to the turn of the century. Read More

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Šikl's Department of Pathology, Charles University in Prague, The Faculty of Medicine and Faculty Hospital in Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic; Bioptická laboratoř s.r.o., Mikulášske nám. 4, 326 00, Pilsen.

Myositis ossificans (MO) and fibro-osseous pseudotumor of digits (FOPD) are localized, self-limiting bone-producing pseudosarcomatous lesions characterized by nodular fasciitis-like proliferation and osteoid and immature woven bone production, which may eventually develop into more mature lamelar bone. Traditionally, MO/FOPD were thought to be of reactive, non-neoplastic nature. USP6 gene rearrangement was recently reported as a consistent finding in MO and FOPD, thus expanding the spectrum of transient, USP6-rearranged neoplasms. Read More

Acad Med 2019 Apr 2. Epub 2019 Apr 2.

E. Stergiopoulos is a fourth-year medical student, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. R.H. Ellaway is professor, Department of Community Health Sciences, and director, Office of Health & Medical Education Scholarship, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; ORCID: https://orcid.org/0000-0002-3759-6624. N. Nahiddi is a resident, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Québec, Canada. M.A. Martimianakis is associate professor and director, Medical Education Scholarship, Department of Paediatrics, and scientist and associate director International and Partnerships, The Wilson Centre, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; ORCID: https://orcid.org/0000-0002-2531-3156.

Purpose: There has been scant scholarly attention paid to characterizing how the numerous definitions of terms associated with compassion and humanism have been mobilized or what the organizational implications of pursuing different constructs might be. This study explored the uses and implications of the terminology associated with humanistic medicine in the work of the Associated Medical Services (AMS) Phoenix Project.

Method: This study involved two phases (2014-2015). Read More

Eur Arch Paediatr Dent 2019 Apr 3. Epub 2019 Apr 3.

EAPD Editor in Chief, Athens, Greece.

Orphanet J Rare Dis 2019 Apr 3;14(1):76. Epub 2019 Apr 3.

Institute of Genetics, Newcastle University, Newcastle upon Tyne, UK.

Background: Discussions continue as to whether ventricular septal defects are best categorized according to their right ventricular geography or their borders. This is especially true when considering the perimembranous defect. Our aim, therefore, was to establish the phenotypic feature of the perimembranous defect, and to establish the ease of distinguishing its geographical variants. Read More

J Chem Inf Model 2019 Apr 3. Epub 2019 Apr 3.

Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States.

The success of hit-finding campaigns relies on many factors, including the quality and diversity of the set of compounds that is selected for screening. This paper presents a generalized workflow that guides compound selections from large compound archives with opportunities to bias the selections with available knowledge in order to improve hit quality while still effectively sampling the accessible chemical space. An optional flag in the workflow supports an explicit complement design function where diversity selections complement a given core set of compounds. Read More

APMIS 2019 Apr 3. Epub 2019 Apr 3.

Pathology, Fimlab Laboratories, Arvo Ylpön katu 4, 33520, Tampere, Finland.

Cytopathological Features of Secretory Carcinoma of Salivary Glands and Ancillary Techniques in Its Diagnostics: Impact of a New Milan System for Reporting Salivary Gland Cytopathology Secretory carcinoma (SC) of salivary glands is a newly described low-grade malignancy characterized by the presence of ETV6 rearrangement. Only a few cases and very small series with cytomorphology were reported so far. Six cases of fine-needle aspirations (FNA) from afterward histologically, immunohistochemically and genetically confirmed SCs were retrieved from the archives of the authors. Read More

Gigascience 2019 Apr;8(4)

Epigenetics in Human Health and Disease, Central Clinical School, Faculty of Medicine, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia.

Background: RNA sequencing (RNA-seq) is an indispensable tool in the study of gene regulation. While the technology has brought with it better transcript coverage and quantification, there remain considerable barriers to entry for the computational biologist to analyse large data sets. There is a real need for a repository of uniformly processed RNA-seq data that is easy to use. Read More

Stud Health Technol Inform 2019 ;258:125-129

National Medical Research Center for Neurosurgery named after N.N. Burdenko, Moscow, Russian Federation.

Electronic Health Records (EHRs) conceal a hidden knowledge that could be mined with data science tools. This is relevant for N.N. Read More