11,409 results match your criteria Arch. Pathol. Lab. Med.[Journal]


Autopsy Report with Clinical Pathological Correlation.

Arch Pathol Lab Med 2020 May 18. Epub 2020 May 18.

From the Department of Pathology and Laboratory Medicine, Long School of Medicine (Drs Yan and Gilbert); the Department of Internal Medicine, Long School of Medicine (Dr Mir); the Division of Pulmonary Disease and Critical Care Medicine, Long School of Medicine (Drs Sanchez, Beg, Peters and Enriquez), University of Texas Health San Antonio, Texas.

Since making its debut on the global stage in December 2019, Coronavirus Disease 2019 (COVID-19) has afflicted nearly four million people and caused hundreds of thousands of deaths. Case reports and case series depicting the clinical effects of the causative virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been published, yet few demonstrate the cytopathologic alterations of this disease. We present a clinical-pathological correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS), and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Read More

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http://dx.doi.org/10.5858/arpa.2020-0217-SADOI Listing

Effects of SARS-CoV-2 infection on pregnant women and their infants: A retrospective study in Wuhan, China.

Arch Pathol Lab Med 2020 May 18. Epub 2020 May 18.

Department of Laboratory Medicine, School of Medicine, Yangtze University, Jingzhou 434023, Hubei, P. R. China (Dr. Hui Yang); Department of Gynecology and Obstetrics, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan 430022, P. R. China. (Dr. Bin Hu, Mr. Guoping Xiong); Department of Digestive Surgical Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China (Dr. Sudong Zhan); Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou 521021, P. R. China (Dr. Li-ye Yang).

The pandemic of a novel coronavirus, termed SARS-CoV-2, has created an unprecedented global health burden. To investigate the effect of the SARS-CoV-2 infection on maternal, fetal, and neonatal morbidity and other poor obstetrical outcomes. All suspected cases of pregnant women with Coronavirus Disease 2019 (COVID-19) admitted into one center of Wuhan from Jan 20, 2020 to March 19, 2020 were included. Read More

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http://dx.doi.org/10.5858/arpa.2020-0232-SADOI Listing

Creation and benefits of the "COVID Autopsy Listserve".

Arch Pathol Lab Med 2020 May 18. Epub 2020 May 18.

Department of Pathology & Laboratory Medicine, Zucker School of Medicine at Hofstra / Northwell, Hempstead, NY.

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http://dx.doi.org/10.5858/arpa.2020-0300-LEDOI Listing

E-Cigarette or Vaping Product Use-Associated Lung Injury: A Review for Pathologists.

Arch Pathol Lab Med 2020 May 13. Epub 2020 May 13.

From the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Dr Cecchini); Department of Pathology, Cleveland Clinic, Cleveland, Ohio (Drs Mukhopadhyay and Arrossi); Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Beasley); Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona (Drs Butt, Smith, Tazelaar, and Larsen); Department of Pathology, University of California San Francisco, San Francisco (Dr Jones); Department of Pathology, Loyola University Medical Center and Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois (Dr Pambuccian); Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Mehrad); Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (Dr Monaco); Department of Pathology & Cell Biology, Columbia University Medical Center, New York, New York (Dr Saqi).

Context.—: Vaping is the inhalation of heated aerosol from a small battery-powered device as a method to deliver nicotine or other substances. A recent outbreak of severe respiratory illness primarily in the United States has put a spotlight on vaping and its potential risks. Read More

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http://dx.doi.org/10.5858/arpa.2020-0024-RADOI Listing

Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guideline From the College of American Pathologists in Collaboration With the American College of Chest Physicians, Association for Molecular Pathology, American Society of Cytopathology, American Thoracic Society, Pulmonary Pathology Society, Papanicolaou Society of Cytopathology, Society of Interventional Radiology, and Society of Thoracic Radiology.

Arch Pathol Lab Med 2020 May 13. Epub 2020 May 13.

From the Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston (Dr Roy-Chowdhuri); Thoracic Surgery and Interventional Pulmonology, Swedish Cancer Institute, Seattle, Washington (Dr Gilbert); the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (Dr Dacic); the Department of Pathology, PeaceHealth Southwest Medical Center, Vancouver, Washington (Dr Ghofrani); the Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland (Dr Illei); the Department of Pathology and Anatomic Sciences, University of Missouri, Columbia (Dr Layfield); the Department of Radiology, Keck Medical Center of the University of Southern California, Los Angeles (Dr Lee); the Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio (Dr Michael); Memorial Pathology Consultants, PA, Houston, Texas (Dr Miller); the Department of Radiology, Capital Regional Medical Center, Tallahassee, Florida (Dr Mitchell); the Department of Interventional and Vascular Radiology, Cooley Dickinson Hospital, Northampton, Massachusetts (Dr Nikolic); the Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York (Dr Nowak); the Division of Pulmonary and Critical Care, Medical University of South Carolina, Charleston (Dr Pastis); the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Rauch); the Department of Radiology, Massachusetts General Hospital, Boston (Dr Sharma); the Methodology Consultant, Ontario, Canada (Dr Souter); the Departments of Governance Services (Ms Billman) and Surveys (Ms Thomas), College of American Pathologists, Northfield, Illinois; the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (Dr VanderLaan); the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Voss); the Division of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, North Carolina (Dr Wahidi); and the Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD (Dr Yarmus).

Context.—: The need for appropriate specimen use for ancillary testing has become more commonplace in the practice of pathology. This, coupled with improvements in technology, often provides less invasive methods of testing, but presents new challenges to appropriate specimen collection and handling of these small specimens, including thoracic small biopsy and cytology samples. Read More

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http://dx.doi.org/10.5858/arpa.2020-0119-CPDOI Listing

Variability in the Laboratory Measurement of Cytokines: A Longitudinal Summary of a College of American Pathologists Proficiency Testing Survey.

Arch Pathol Lab Med 2020 May 13. Epub 2020 May 13.

From the Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora (Dr Knight); Department of Biostatistics, College of American Pathologists, Northfield, Illinois (Mr Long); Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston (Dr Meng); Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (Dr Linden); Department of Pathology, Case Western Reserve University, Cleveland, Ohio (Dr Rhoads).

Context.—: The measurement of cytokines in clinical laboratories is becoming an increasingly routine part of immune monitoring when administering biologic and cell-based immunotherapies and also for clinical assessment of inflammatory conditions. While a number of commercial assays and platforms are available for cytokine measurement, there is currently little standardization among these analytical methods. Read More

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http://dx.doi.org/10.5858/arpa.2019-0519-CPDOI Listing

Recent Advances in Anatomic and Clinical Pathology Board Examination Pass Rates.

Authors:
Brian D Adkins

Arch Pathol Lab Med 2020 May 8. Epub 2020 May 8.

From the Department of Pathology, University of Virginia Health System, Charlottesville.

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http://dx.doi.org/10.5858/arpa.2019-0594-EDDOI Listing

Primary Amyloidosis of the Genitourinary Tract.

Arch Pathol Lab Med 2020 May 8. Epub 2020 May 8.

From the Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis.

Context.—: Amyloidosis is caused by the deposition of misfolded proteins as insoluble eosinophilic material in the extracellular tissues of the body, leading to impairment of organ function. It can be systemic or localized. Read More

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http://dx.doi.org/10.5858/arpa.2020-0102-RADOI Listing

Overview of Pathologic Findings of Vaping in the Context of an Autopsy Patient With Chronic Injury.

Arch Pathol Lab Med 2020 May 8. Epub 2020 May 8.

From the Departments of Pathology (Drs Priemer, Gravenmier, and Hooper) and Radiology (Dr Batouli), Johns Hopkins University, Baltimore, Maryland.

Context.—: Electronic cigarettes are handheld devices that heat an inner liquid containing chemicals to be aerosolized and inhaled, and have become a popular alternative to conventional cigarettes. Their use, termed , has been linked to severe injury, with 2711 cases of associated lung injury and 60 deaths reported to the Centers for Disease Control and Prevention at time of writing. Read More

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http://dx.doi.org/10.5858/arpa.2019-0637-RADOI Listing

SARS-CoV-2 Pandemic: Review of the Literature and Proposal for Safe Autopsy Practice.

Arch Pathol Lab Med 2020 May 8. Epub 2020 May 8.

Institute of Legal Medicine and Department of Surgical and Medical Sciences (Dr. Aquila, Dr. Sacco, Mr. C Ricci, Dr. Gratteri, Dr. P Ricci), Department of Health Sciences (Dr. Abenavoli), and Department of Clinical and Experimental Medicine (Dr. Malara), at the University "Magna Graecia" of Catanzaro, Italy; Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy (Dr. Arena); Department of Health Surveillance and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (Dr. Grassi, Dr. Ausania, Dr. Oliva); JC Self research Institute, Greenwood Genetic Center, Greenwood, SC, USA (DR. Boccuto); School of Health Research, Clemson University, Clemson, SC. USA (Dr, Boccuto).

The novel coronavirus disease 2019 (COVID-19) pandemic is significantly changing methodological approaches in all branches of the health system. From a forensic point of view, this event is partly changing the manner in which forensic pathologists and all those who work in autopsy services operate, but above all, it is changing the patterns established for years by which cadavers were analysed . To present a review of the literature and a proposal for COVID autopsy protocols. Read More

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http://dx.doi.org/10.5858/arpa.2020-0165-SADOI Listing

Leveraging Technology for Remote Learning in the Era of COVID-19 and Social Distancing: Tips and Resources for Pathology Educators and Trainees.

Arch Pathol Lab Med 2020 May 4. Epub 2020 May 4.

Department of Pathology, Cleveland Clinic, Cleveland, OH (Dr. Mukhopadhyay, Dr. Doxtader); Department of Pathology, University of Texas Medical Branch, Galveston, TX (Dr. Booth); Department of Pathology, University of California, San Francisco (Dr. Calkins); Department of Pathology, Memorial Sloan Kettering Cancer Center (Dr. Fine); Departments of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock (Dr. Gardner); Department of Pathology, Beth Israel Deaconess Medical Center (Dr. Gonzalez); Department of Pathology and Laboratory Medicine, Loyola University Health System, Maywood, IL (Dr. Mirza); Department of Pathology, Duke University Medical Center (Dr. Jiang).

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes of operation in healthcare and education. In March 2020, institutions in the United States began to implement a range of policies to discourage direct contact and encourage social distancing. These measures have placed us in an unprecedented position where education can no longer occur at close quarters - most notably, around a multi-headed microscope - but must instead continue at a distance. Read More

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http://dx.doi.org/10.5858/arpa.2020-0201-EDDOI Listing

A Bayesian analysis of strategies to rule out COVID19 using reverse transcriptase-polymerase chain reaction (RT-PCR).

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

Division of Clinical Data Analytics and Decision Support (Dr. Raschke, Dr. Curry, Dr. Iyengar), Department of Medicine (Dr Raschke, Dr. Curry, Dr. Gutierrez, Dr. Iyengar), University of Arizona College of Medicine - Phoenix, Phoenix, AZ; Medical/Surgical Intensive Care Unit, Honorhealth Osborn Medical Center, Scottsdale, AZ (Dr. Glenn); Department of Infectious Disease, Phoenix Veterans Administration Hospital, Phoenix, AZ (Dr. Gutierrez).

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http://dx.doi.org/10.5858/arpa.2020-0196-LEDOI Listing

The Development and Implementation of a Novel Electronic Consult System by a Laboratory Medicine Service: Experience From the First 2 Years of Use.

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

From the Departments of Pathology (Drs Stendahl and Siddon) and Laboratory Medicine (Drs Stendahl, Siddon, Peaper, Hauser, Campbell, and Tormey), Yale School of Medicine, New Haven, Connecticut; and Pathology & Laboratory Medicine Service (Drs Stendahl, Siddon, Peaper, Hauser, Campbell, and Tormey), VA Connecticut Healthcare System, West Haven, Connecticut.

Context.—: A novel electronic consult (e-consult) system for a pathology and laboratory medicine service (PLMS) was implemented in 2015 at a high-complexity Veterans Administration health care facility. Consults were previously made through direct provider communication without documentation in the medical record. Read More

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http://dx.doi.org/10.5858/arpa.2019-0267-OADOI Listing

Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy.

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Immune checkpoint inhibitors (CPIs), including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors and the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors, are being increasingly used for treating many advanced malignancies. However, CPI therapy is also associated with gastrointestinal and hepatobiliary adverse effects. Read More

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http://dx.doi.org/10.5858/arpa.2020-0070-RADOI Listing

INFECTIONS IN PREGNANCY WITH COVID-19 AND OTHER RESPIRATORY RNA VIRUS DISEASES ARE RARELY, IF EVER, TRANSMITTED TO THE FETUS: EXPERIENCES WITH CORONAVIRUSES, HPIV, hMPV RSV, AND INFLUENZA.

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA (Dr. Schwartz); Amareen Dhaliwal, BS, Boston University School of Medicine, Boston, MA, USA (Ms. Dhaliwal).

SARS-CoV-2, the agent of COVID-19, is similar to two other coronaviruses, SARS-CoV and MERS-CoV, in causing life-threatening maternal respiratory infections and systemic complications. Because of global concern for potential intrauterine transmission of SARS-CoV-2 from pregnant women to their infants, this report analyzes the effects on pregnancy of infections caused by SARS-CoV-2 and other respiratory RNA viruses, and examines the frequency of maternal-fetal transmission with SARS-CoV-2, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza, respiratory syncytial virus (RSV), parainfluenza (HPIV) and metapneumovirus (hMPV). There have been no confirmed cases of intrauterine transmission reported with COVID-19 or any other coronavirus infections. Read More

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http://dx.doi.org/10.5858/arpa.2020-0211-SADOI Listing

In Reply.

Arch Pathol Lab Med 2020 May;144(5):543-544

Department of Pathology, Grant Medical College, and Sir J. J. Hospital, Mumbai, India.

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http://dx.doi.org/10.5858/arpa.2019-0563-LEDOI Listing

Gharpure's Papers (1927-1951) on Autopsies at Grant Medical College and Sir J. J. Hospital, Mumbai.

Arch Pathol Lab Med 2020 May;144(5):543

Department of Neurosurgery, Jaslok Hospital, Mumbai, India.

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http://dx.doi.org/10.5858/arpa.2019-0479-LEDOI Listing

Select Epstein-Barr Virus-Associated Digestive Tract Lesions for the Practicing Pathologist.

Arch Pathol Lab Med 2020 Apr 22. Epub 2020 Apr 22.

From the Department of Pathology, Regional Laboratory and Blood Bank, Eastern Province, Dammam, Saudi Arabia (Dr Alruwaii); and the Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland (Dr Montgomery).

Context.—: Epstein-Barr virus is a ubiquitous oncogenic virus. During the past 5 decades, the virus has been linked to several disease entities, both neoplastic and nonneoplastic. Read More

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http://dx.doi.org/10.5858/arpa.2019-0703-RADOI Listing

Transbronchial Cryobiopsy in the Diagnosis of Fibrotic Interstitial Lung Disease.

Arch Pathol Lab Med 2020 Apr 22. Epub 2020 Apr 22.

From the Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Mehrad); the Department of Pathology, Mayo Clinic, Scottsdale, Arizona (Dr Colby); the Pathology Unit, Azienda USL della Romagna, St. Maria delle Croci Hospital, Ravenna, Italy (Dr Rossi); and the Pathology Unit, Azienda USL/IRCCS di Reggio Emilia, Reggio Emilia, Italy (Dr Cavazza).

Context.—: Transbronchial cryobiopsy is an emerging procedure to obtain lung tissue for diagnosis of interstitial lung disease and has gained popularity because it is less invasive and has a lower rate of complications compared with nonselective surgical lung biopsy.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2020-0007-RADOI Listing

COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation.

Arch Pathol Lab Med 2020 Apr 17. Epub 2020 Apr 17.

Department of Pathology and Cell Biology (Dr. Lagana, Dr. De Michele, Dr. Lee, Dr. Lefkowitch); Department of Surgery (Dr. Emond, Dr. Griesemer); Department of Radiology (Dr Tulin-Silver); Department of Medicine Digestive and Liver Disease (Dr. Verna); Department of Pediatrics (Dr. Martinez), at the Columbia University Medical Center.

We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. Read More

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http://dx.doi.org/10.5858/arpa.2020-0186-SADOI Listing

Defining Normal Healthy Term Newborn Automated Hematologic Reference Intervals at 24 Hours of Life.

Arch Pathol Lab Med 2020 Apr 16. Epub 2020 Apr 16.

From the Division of Neonatal Medicine, MEDNAX Services, Inc, Phoenix Perinatal Associates, Phoenix, Arizona; University of Arizona College of Medicine - Phoenix; and Neonatal Intensive Care Unit, Banner - University Medical Center Phoenix, Phoenix, Arizona (Dr Ianni); Laboratory, Banner Desert and Cardons Children's Medical Centers, Laboratory Sciences of Arizona, Mesa (Dr McDaniel); Laboratory, Banner - University Medical Center Phoenix, Laboratory Sciences of Arizona, Phoenix (Dr Savilo); Clinical Research, Division of Neonatal Medicine, MEDNAX Services, Inc, Phoenix Perinatal Associates, Phoenix, Arizona (Ms Wade, Ms Micetic, and Mr Johnson); and the Department of Internal Medicine, Banner - University Medical Center Phoenix, Phoenix, Arizona and University of Arizona College of Medicine - Phoenix (Dr Gerkin).

Context.—: Automated analyzers have advanced the field of clinical hematology, mandating updated complete blood count (CBC) reference intervals (RIs) to be clinically useful. Contemporary newborn CBC RI publications are mostly retrospective, which some authors have cited as one of their cardinal limitations and recommended future prospective studies. Read More

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http://dx.doi.org/10.5858/arpa.2019-0444-OADOI Listing

Geospatial Hotspots Need Point-of-Care Strategies to Stop Highly Infectious Outbreaks: Ebola and Coronavirus.

Authors:
Gerald J Kost

Arch Pathol Lab Med 2020 Apr 16. Epub 2020 Apr 16.

Emeritus Professor, CEO, Knowledge Optimization, Director, POCT•CTR (Point-of-care Testing Center for Teaching and Research), University of California, Davis, 506 Citadel Drive, Davis, CA 95616.

Point-of-care testing (POCT), diagnostic testing at or near the site of patient care, is , that is, performed at points of need, and also , because it produces fast actionable results. Outbreaks generate geospatial "hotspots." help control hotspots, detect spread, and speed treatment of highly infectious diseases. Read More

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http://dx.doi.org/10.5858/arpa.2020-0172-RADOI Listing

Pancreatic Neuroendocrine Neoplasms: Landscape and Horizon.

Authors:
Laura H Tang

Arch Pathol Lab Med 2020 Apr 16. Epub 2020 Apr 16.

From the Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.

Context.—: Since the initial description of pancreatic endocrine physiology and the recognition of islet cell tumors in the 1800s, there have been noteworthy advances in the pathobiology of pancreatic neuroendocrine neoplasms (PanNENs), and definition of the important distinction between well-differentiated neuroendocrine tumor (PanNET) and poorly differentiated neuroendocrine carcinoma (PanNEC). The evolving knowledge has resulted in a continuous update in terminology, classification, and grading system for this group of neoplasms. Read More

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http://dx.doi.org/10.5858/arpa.2019-0654-RADOI Listing

VIRAL TRANSPORTATION IN COVID-19 PANDEMIC: INACTIVATED VIRUS TRANSPORTATION SHOULD BE IMPLEMENTED FOR SAFE TRANSPORTATION AND HANDLING AT DIAGNOSTICS LABORATORIES.

Arch Pathol Lab Med 2020 Apr 16. Epub 2020 Apr 16.

Department of Pathology, University of Michigan, Ann Arbor Michigan (Dr. Dewar); Pathnostics Inc, Irvine, California (Dr. Baunoch); Department of Pathology, Yale School of Medicine, New Haven, Connecticut (Dr. Wojno); Oncocell dx, Royal Oak, Michigan (Dr. Parkash); Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA (Dr. Khosravi-Far); Accurome Health, Inc. Boston, MA (Dr. Khosravi-Far).

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http://dx.doi.org/10.5858/arpa.2020-0175-LEDOI Listing

Resurrecting the Hospital Autopsy: Impact of an Office of Decedent Affairs on Consent Rates, Providers, and Next-of-Kin.

Arch Pathol Lab Med 2020 Apr 16. Epub 2020 Apr 16.

From the Department of Laboratory Medicine & Pathology (Drs Juskewitch, Maleszewski, Paolini II, Amirahmadi, Reichard, and Aubry and Mss. Regnier, Yrjo, and Kendall), the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery (Drs Griffin, Asiedu, Comfere, and Cheville), the Division of Health Care Policy and Research (Drs Griffin, Comfere, and Cheville), the Department of Dermatology (Dr Comfere), the Division of General Internal Medicine in the Department of Medicine (Dr Carey), the Division of Pulmonary and Critical Care Medicine in the Department of Internal Medicine (Dr Rabatin), and the Division of Medical Oncology in the Department of Oncology (Dr Moynihan), Mayo Clinic, Rochester, Minnesota.

Context.—: Autopsy rates have decreased dramatically despite providing important clinical information to medical practices and social benefits to decedents' families.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0571-OADOI Listing

SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.

Arch Pathol Lab Med 2020 Apr 9. Epub 2020 Apr 9.

From the Departments of Pathology (Drs Nambirajan, Bhardwaj, and Jain and Ms Singh) and Pulmonary Medicine (Dr Mittal), All India Institute of Medical Sciences, New Delhi, India; and the Department of Surgical Oncology, Dr B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India (Dr Kumar).

Context.—: Somatic mutations in (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4) gene and/or BRG1 (Brahma-related gene 1) loss identifies a subset of non-small cell lung carcinomas (NSCLCs) lacking alterations in (epidermal growth factor receptor), (anaplastic lymphoma kinase), and (ROS proto-oncogene 1) genes. Preliminary observations suggest responsiveness to immunotherapy and targeted therapies. Read More

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http://dx.doi.org/10.5858/arpa.2019-0633-OADOI Listing
April 2020
2.838 Impact Factor

Squamous Neoplasia in the Esophagus.

Arch Pathol Lab Med 2020 Apr 9. Epub 2020 Apr 9.

From the Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia (Drs Savant and Yang); and the Department of Pathology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania (Dr Zhang).

Context.—: Squamous lesions of the esophagus encompass a spectrum of disorders ranging from reactive changes and benign papilloma to squamous dysplasia and squamous cell carcinoma, which may pose diagnostic challenges especially in superficial biopsies.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2020-0058-RADOI Listing

Centrilobular Fibrosis in Fibrotic (Chronic) Hypersensitivity Pneumonitis, Usual Interstitial Pneumonia, and Connective Tissue Disease-Associated Interstitial Lung Disease.

Authors:
Andrew Churg

Arch Pathol Lab Med 2020 Apr 1. Epub 2020 Apr 1.

From the Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Context.—: Various pulmonary diseases can produce centrilobular (peribronchiolar) fibrosis, which may be isolated or associated with other patterns of more diffuse fibrosis. The major forms of interstitial lung disease in which centrilobular fibrosis is found are fibrotic (chronic) hypersensitivity pneumonitis, connective tissue disease-associated interstitial lung disease, and (a disputed issue) usual interstitial pneumonia/idiopathic interstitial fibrosis. Read More

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http://dx.doi.org/10.5858/arpa.2019-0628-RADOI Listing

What is New in 2019 World Health Organization (WHO) Classification of Tumors of the Digestive System: Review of Selected Updates on Neuroendocrine Neoplasms, Appendiceal Tumors, and Molecular Testing.

Arch Pathol Lab Med 2020 Apr 1. Epub 2020 Apr 1.

Department of Pathology, the Johns Hopkins University, School of Medicine, Baltimore, Maryland.

Context.—: The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0665-RADOI Listing

Root Cause Analysis of Amendments in Tumor Summaries.

Arch Pathol Lab Med 2020 Apr;144(4):414-415

Departments of Pathology, Baptist Hospital and Miami Cancer Institute, Miami, Florida.

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http://dx.doi.org/10.5858/arpa.2019-0554-LEDOI Listing

From Undergraduate Medical School Student to Visible Pathologist.

Arch Pathol Lab Med 2020 Apr;144(4):413-414

Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.

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http://dx.doi.org/10.5858/arpa.2019-0484-LEDOI Listing

Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy.

Arch Pathol Lab Med 2020 Mar 30. Epub 2020 Mar 30.

From the Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston. Dr Jacobi is currently in the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Dr Broaddus is currently in the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.

Context.—: The approval of pembrolizumab for treatment of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) advanced cancers has led to increased requests for MSI and/or MMR immunoperoxidase (IPOX) testing. Diagnoses for patients with advanced-stage cancer are frequently made from cytology specimens. Read More

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http://dx.doi.org/10.5858/arpa.2019-0398-OADOI Listing

The 8th Edition American Joint Committee on Cancer Staging for Hepato-pancreato-biliary Cancer: A Review and Update.

Arch Pathol Lab Med 2020 Mar 30. Epub 2020 Mar 30.

From the Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.

Context.—: Cancer staging provides critical information for patients and treating physicians to battle against cancer, predict prognosis, and guide treatment decisions. The American Joint Committee on Cancer (AJCC) staging system uses a tumor, node, metastasis (TNM) scoring algorithm and is the foremost classification system for adult cancers. Read More

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http://dx.doi.org/10.5858/arpa.2020-0032-RADOI Listing

Noninvasive Follicular Tumor With Papillary-like Nuclear Features: A Practice Changer in Thyroid Pathology.

Arch Pathol Lab Med 2020 Mar 30. Epub 2020 Mar 30.

From the Department of Pathology & Laboratory Medicine, the Hospital of the University of Pennsylvania, Philadelphia.

Context.—: This article presents a review of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), including its separation from follicular variant of papillary carcinoma of the thyroid, its evolution, and current definition and pathologic characteristics.

Objectives. Read More

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http://dx.doi.org/10.5858/arpa.2019-0689-RADOI Listing

An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes.

Authors:
David A Schwartz

Arch Pathol Lab Med 2020 Mar 17. Epub 2020 Mar 17.

The emergence of a novel coronavirus, termed SARS-CoV-2, and the potentially life-threating respiratory disease that it can produce, COVID-19, has rapidly spread across the globe creating a massive public health problem. Previous epidemics of many emerging viral infections have typically resulted in poor obstetrical outcomes including maternal morbidity and mortality, maternal-fetal transmission of the virus, and perinatal infections and death. This communication reviews the effects of two previous coronavirus infections - severe acute respiratory syndrome (SARS) caused by SARS-CoV and Middle East respiratory syndrome (MERS) caused by MERS-CoV - on pregnancy outcomes. Read More

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http://dx.doi.org/10.5858/arpa.2020-0901-SADOI Listing

Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths.

Arch Pathol Lab Med 2020 Mar 13. Epub 2020 Mar 13.

From Tommy's Maternal and Fetal Health Research Centre, St. Mary's Hospital, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom (Drs Kerby, Baker, Heazell, and Ms Sharps); the Department of Paediatric and Perinatal Pathology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (Ms Batra); and the Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom (Dr Heazell).

Context.—: Women with diabetes have increased stillbirth risk. Although the underlying pathophysiological processes are poorly understood, stillbirth is frequently related to abnormal placental structure and function. Read More

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http://dx.doi.org/10.5858/arpa.2019-0524-OADOI Listing

Hematolymphoid Neoplasms Rarely Mimic Undifferentiated Pleomorphic Sarcoma of Soft Tissue.

Arch Pathol Lab Med 2020 Mar 13. Epub 2020 Mar 13.

From the Departments of Pathology (Drs Cannatella and Horvai) and Laboratory Medicine (Dr Ganapathi), University of California, San Francisco, San Francisco. Dr Cannatella is now with the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

Context.—: Undifferentiated pleomorphic sarcoma (UPS) of soft tissue is defined as a sarcoma with no recognizable line of differentiation. During the past few decades, advances in ancillary studies and review of prior UPS diagnoses have narrowed the category of UPS by excluding more-specific malignancies. Read More

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http://dx.doi.org/10.5858/arpa.2019-0580-OADOI Listing

Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Medicine, Division of Cardiology, Weill Cornell Medicine, New York, New York (Drs Sobol and Mahmood); the Department of Medicine, Division of Cardiology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Chen); and Weill Cornell Pathology, New York, New York (Dr Borczuk).

Context.—: Cardiac complications of immune checkpoint inhibitor therapy are rare, but reports of myocarditis are increasing. The findings have been described in case reports as lymphocytic myocarditis, but its histopathology is underreported. Read More

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http://dx.doi.org/10.5858/arpa.2019-0447-OADOI Listing

Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Anatomical Pathology (Mr Chow, Drs Thike and Tan, and Ms Nasir), Division of Pathology (Drs Yeong and Tan), and Division of Research (Dr Li), Singapore General Hospital, Singapore; the Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (ASTAR), Singapore (Dr Yeong); the Duke-NUS Medical School, Singapore (Drs Thike and Tan); and the University of Tasmania, Tasmania, Australia (Mr Chow).

Context.—: Mitotic count is an important histologic criterion for grading and prognostication in phyllodes tumors (PTs). Counting mitoses is a routine practice for pathologists evaluating neoplasms, but different microscopes, variable field selection, and areas have led to possible misclassification. Read More

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http://dx.doi.org/10.5858/arpa.2019-0435-OADOI Listing
March 2020
2.838 Impact Factor

Variants in Epithelial-Mesenchymal Transition and Immune Checkpoint Genes Are Associated With Immune Cell Profiles and Predict Survival in Non-Small Cell Lung Cancer.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston (Drs Parra and Jiang); the Department of Pathology and Laboratory of Genomics and Histomorphometry (Drs Machado-Rugolo, Yaegashi, Prieto, Farhat, de Sá, and Capelozzi) and the Division of Pneumology, Heart Institute (Incor) (Dr Takagaki), Faculty of Medicine, University of São Paulo, São Paulo, Brazil; the Department of Oncology, Clinicas Hospital, Faculty of Medicine, São Paulo State University, São Paulo, Brazil (Drs de Sá and Nagai); the Medical Oncology Department and Translational Immune-Oncology Group, A. C. Camargo Cancer Center, São Paulo, Brazil (Drs de Sá and de Lima); the Department of Thoracic Surgery, Institute of Cancer of São Paulo, São Paulo, Brazil (Dr Terra); the Department of Thoracic Surgery, Heart Institute (Incor), São Paulo, Brazil (Dr Terra); and the Department of Pathology and Legal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil (Dr Fabro).

Context.—: Identification of gene mutations that are indicative of epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to immune checkpoint inhibitors.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0419-OADOI Listing

Genotype and Phenotype Concordance for Pharmacogenetic Tests Through Proficiency Survey Testing: An Update.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Drs Moyer and Gandhi); the Department of Pathology and ARUP Laboratories, University of Utah School of Medicine, Salt Lake City (Drs McMillin, Mao, and Smock); Biostatistics (Mr Long) and Proficiency Testing (Ms Halley), College of American Pathologists, Northfield, Illinois; and the Department of Pathology and Laboratory Medicine and Department of Genetics, University of North Carolina, Chapel Hill (Dr Weck).

Context.—: As pharmacogenetic testing is incorporated into routine care, it is essential for laboratories to provide accurate and consistent results. Certified laboratories must successfully complete proficiency testing. Read More

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http://dx.doi.org/10.5858/arpa.2019-0478-CPDOI Listing

Lack of Standardization in the Processing and Reporting of Post-Neoadjuvant Breast Cancer Specimens: A Survey of Canadian Pathologists and Pathology Assistants.

Arch Pathol Lab Med 2020 Mar 6. Epub 2020 Mar 6.

From the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada (Dr Han); the Department of Anatomic Pathology, University of Ottawa and Eastern Ontario Regional Laboratory Association, Ottawa, Canada (Ms Regpala); and the Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (Drs Slodkowska, Nofech-Mozes, Hanna, Parra-Herran, and Lu).

Context.—: The use of neoadjuvant therapy in the management of early-stage invasive breast cancer is increasing. Residual Cancer Burden and other similar tools use pathologic characteristics of post-neoadjuvant therapy breast tumors to determine long-term outcome. Read More

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http://dx.doi.org/10.5858/arpa.2019-0539-OADOI Listing

Impact of the Updated 2018 American Society of Clinical Oncology/College of American Pathologists Guideline for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer.

Arch Pathol Lab Med 2020 Mar 6. Epub 2020 Mar 6.

From the Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; the Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; and the Institute of Pathology, Fudan University, Shanghai, China.

Context.—: The updated American Society of Clinical Oncology/College of American Pathologists guideline for human epidermal growth factor receptor 2 (HER2) testing in breast cancer requires pathologists to re-evaluate HER2 status.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0369-OADOI Listing

Placentas From Women of Advanced Maternal Age: An Independent Indication for Pathologic Examination?

Arch Pathol Lab Med 2020 Feb 26. Epub 2020 Feb 26.

From the Department of Pathology, Massachusetts General Hospital, Boston, and Harvard Medical School, Boston, Massachusetts.

Context.—: The percentage of pregnant women with advanced maternal age (AMA) has increased during the past several decades due to various socioeconomic factors and advances in assisted reproduction. These pregnancies are associated with adverse maternal and fetal outcomes. Read More

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http://dx.doi.org/10.5858/arpa.2019-0481-OADOI Listing
February 2020

Apixaban Does Not Interfere With Protein S or Activated Protein C Resistance (Factor V Leiden) Testing Using aPTT-Based Methods.

Arch Pathol Lab Med 2020 Feb 26. Epub 2020 Feb 26.

From the Department of Pathology, Massachusetts General Hospital, Boston.

Context.—: Apixaban causes a false increase in activated protein C resistance (APCR) ratios and possibly protein S activity.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0497-OADOI Listing
February 2020

HER2 Dual In Situ Hybridization: Correlations and Cautions.

Arch Pathol Lab Med 2020 Feb 26. Epub 2020 Feb 26.

From the Department of Pathology, Stanford University Medical Center, Stanford, California.

Context.—: Accurate HER2 testing in breast cancer is crucial for appropriate precision therapy. HER2 testing is most commonly accomplished by a combination of immunohistochemistry and in situ hybridization techniques, as gene amplification is closely tied to protein overexpression. Read More

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http://dx.doi.org/10.5858/arpa.2019-0510-OADOI Listing
February 2020

Challenges for Data Extraction From Narrative Pathology Reports.

Authors:
Zhenhong Qu

Arch Pathol Lab Med 2020 Mar;144(3):273

Department of Pathology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan.

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http://dx.doi.org/10.5858/arpa.2019-0543-LEDOI Listing

Application and Pitfalls of Immunohistochemistry in Diagnosis of Challenging Genitourinary Cases.

Arch Pathol Lab Med 2020 Mar;144(3):290-304

From the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Context.—: Immunohistochemistry (IHC) has become increasingly important in the evaluation of pathologic conditions in the genitourinary (GU) organs. In addition to careful evaluation of hematoxylin-eosin sections and generation of a differential diagnosis, choosing the optimal panel of IHC markers becomes even more important when the biopsy material is very limited. Read More

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http://dx.doi.org/10.5858/arpa.2019-0550-RADOI Listing

Updates in Histologic Grading of Urologic Neoplasms.

Arch Pathol Lab Med 2020 Mar;144(3):335-343

From the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Context.—: Tumor histology offers a composite view of the genetic, epigenetic, proteomic, and microenvironmental determinants of tumor biology. As a marker of tumor histology, histologic grading has persisted as a highly relevant factor in risk stratification and management of urologic neoplasms (ie, renal cell carcinoma, prostatic adenocarcinoma, and urothelial carcinoma). Read More

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http://dx.doi.org/10.5858/arpa.2019-0551-RADOI Listing

Frontiers in Genitourinary Pathology.

Arch Pathol Lab Med 2020 Mar;144(3):275-276

From the Department of Pathology, Duke University School of Medicine, Durham, North Carolina (Dr Huang); and the Department of Pathology, Princeton Medical Center, Plainsboro, New Jersey, the Department of Biological Sciences, Rutgers University, Newark, New Jersey, the Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, New Jersey, and Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey (Dr Zhang).

This special section includes 4 articles as the proceedings of the Fifth Princeton Integrated Pathology Symposium (PIPS): Genitourinary Pathology, and an update on neuroendocrine tumor of the prostate. The symposium took place at the Princeton Medical Center, Plainsboro, New Jersey, on Sunday April 15, 2018. We hope again that this collection of outstanding reviews will serve as a handy reference for your daily practice. Read More

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http://dx.doi.org/10.5858/arpa.2019-0560-EDDOI Listing
March 2020
2.838 Impact Factor