11,181 results match your criteria Arch. Pathol. Lab. Med.[Journal]


Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the BRAF, EGFR, and KRAS Genes: A Study of the College of American Pathologists Molecular Oncology Committee.

Arch Pathol Lab Med 2019 Apr 10. Epub 2019 Apr 10.

From the Office of the Director, The Joint Pathology Center, Silver Spring, Maryland (Dr Moncur); the Department of Pathology, St Joseph Mercy Hospital, Ypsilanti, Michigan (Dr Bartley); the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha (Dr Bridge); the Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada (Dr Kamel-Reid); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Lindeman and Kim); Biostatistics (Mr Long) and Proficiency Testing (Ms Vasalos), College of American Pathologists, Northfield, Illinois; the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill (Dr Merker); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Rai); the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Rimm); and the Department of Pathology and Laboratory Medicine, Strong Memorial Hospital, University of Rochester Medical Center and Pathology and Laboratory Medicine, Molecular Diagnostic Laboratory, Rochester, New York (Dr Rothberg).

Context.—: The performance of laboratory testing has recently come under increased scrutiny as part of important and ongoing debates on regulation and reimbursement. To address this critical issue, this study compares the performance of assay methods, using either commercial kits or assays designed and implemented by single laboratories ("home brews"), including next-generation sequencing methods, on proficiency testing provided by the College of American Pathologists Molecular Oncology Committee. Read More

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http://dx.doi.org/10.5858/arpa.2018-0396-CPDOI Listing

Comparison of Different Small Clinical Hematology Laboratory Configurations With Focus on Remote Smear Imaging.

Arch Pathol Lab Med 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Pathology, University of California, San Diego/University of California San Diego Health, La Jolla (Drs Stephens, Bevins, and Broome); the Department of Scientific Affairs, CellaVision AB, Lund, Sweden (Mr Bengtsson); and the University of California San Diego Moores Cancer Center, La Jolla (Dr Broome).

Context.—: Stand-alone clinical sites (eg, infusion centers) are becoming increasingly common. These sites require timely hematology analysis. Read More

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http://dx.doi.org/10.5858/arpa.2018-0277-OADOI Listing

Cytoplasmic Fibrillar Aggregates in Gallbladder Epithelium Are a Frequent Mimic of Cystoisospora in Pediatric Cholecystectomy Specimens.

Arch Pathol Lab Med 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Pathology, University of Maryland Medical Center, Baltimore (Dr Rose); the Department of Pathology, The Ohio State University Wexner Medical Center, Columbus (Drs C. A. Arnold, Badizadegan, Carter, Conces, Kahwash, Nicol, and M. A. Arnold); and the Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio (Drs Badizadegan, Carter, Conces, Kahwash, Nicol, and M. A. Arnold). Dr Carter is now with Indiana University Health, Southern Indiana Pathologists, Bloomington.

Context.—: Cystoisospora belli is an intracellular parasite associated with gastrointestinal disease in immunocompromised hosts. Although infection has been classically associated with intestinal disease, studies have identified Cystoisospora in the gallbladder of immunocompetent patients based on hematoxylin-eosin morphology. Read More

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http://dx.doi.org/10.5858/arpa.2018-0335-OADOI Listing
April 2019
1 Read

Placental Pathology in Down Syndrome-Associated Transient Abnormal Myelopoiesis.

Arch Pathol Lab Med 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

Transient abnormal myelopoiesis is a hematopoietic disorder that occurs in up to 10% of neonates with Down syndrome. It is characterized by leukocytosis and the presence of circulating blast cells harboring truncating GATA1 mutations with variable multiorgan system involvement. Placental involvement of transient abnormal myelopoiesis is infrequently described. Read More

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http://dx.doi.org/10.5858/arpa.2018-0248-RSDOI Listing

Histologic Diagnosis of Renal Mass Biopsy.

Arch Pathol Lab Med 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.

Context.—: Core biopsy has been increasingly used for clinical decision-making in the management of patients with renal masses. The sensitivity and specificity of histologic diagnoses of renal mass biopsies depend on many factors such as adequate sampling and tissue processing, diagnostic skill and experience, and appropriate use of ancillary techniques. Read More

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http://dx.doi.org/10.5858/arpa.2018-0272-RADOI Listing

Autoimmune Lymphoproliferative Syndrome: An Overview.

Arch Pathol Lab Med 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison.

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited nonmalignant lymphoproliferative disorder characterized by heterozygous mutations within the first apoptosis signal receptor (FAS) signaling pathway. Defects in FAS-mediated apoptosis cause an expansion and accumulation of autoreactive CD4 and CD8 (double-negative) T cells, leading to cytopenias, splenomegaly, lymphadenopathy, autoimmune disorders, and a greatly increased lifetime risk of lymphoma. The differential diagnosis of ALPS includes infection, other inherited immunodeficiency disorders, primary and secondary autoimmune syndromes, and lymphoma. Read More

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http://dx.doi.org/10.5858/arpa.2018-0190-RSDOI Listing
April 2019
3 Reads

Delta-like Protein 3 Prevalence in Small Cell Lung Cancer and DLL3 (SP347) Assay Characteristics.

Arch Pathol Lab Med 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Companion Diagnostics, Ventana Medical Systems, Tucson, Arizona.

Context.—: Delta-like protein 3 (DLL3) is a protein that is implicated in the Notch pathway.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0497-OADOI Listing

Anastomosing Hemangioma: Short Review of a Benign Mimicker of Angiosarcoma.

Arch Pathol Lab Med 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Pathology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.

Anastomosing hemangioma is a rare neoplastic vascular lesion, histologically mimicking angiosarcoma. It is predominantly composed of irregularly anastomosing sinusoidal-like spaces lined by endothelial cells with minimal atypia, a frequently hobnail morphology, and minimally invasive margins. Since its original description in the genitourinary system, an increasing number of anastomosing hemangiomas have been reported, localized deep in the body in various organs, always with similar histologic features. Read More

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http://dx.doi.org/10.5858/arpa.2018-0264-RSDOI Listing
April 2019
1 Read

Pathology Engagement in Global Health: Exploring Opportunities to Get Involved.

Arch Pathol Lab Med 2019 Apr;143(4):418-421

From the Department of Pathology, New York Medical College at Westchester Medical Center, Valhalla (Dr Razzano); the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Drs Hall and Jiang); and the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Gardner).

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http://dx.doi.org/10.5858/arpa.2018-0280-EDDOI Listing
April 2019
2.838 Impact Factor

Report Standardization in Transbronchial Lung Cryobiopsy.

Arch Pathol Lab Med 2019 Apr;143(4):416-417

1  Department of Diseases of the Thorax (Drs Ravaglia, Tomassetti, and Poletti), G.B. Morgagni - L. Pierantoni Hospital, Forlì, Italy.

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http://dx.doi.org/10.5858/arpa.2018-0438-LEDOI Listing

External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program.

Arch Pathol Lab Med 2019 Apr 21;143(4):472-482. Epub 2018 Dec 21.

From the Department of Laboratories, Seattle Children's Hospital, Seattle, Washington (Dr Chandler); the Department of Pathology, University of Utah, Salt Lake City (Drs Brown and Smock); Special Coagulation Laboratory, Mayo Clinic, Rochester, Minnesota (Dr Chen); the Department of Pathology, St. Louis University School of Medicine, St Louis, Missouri (Dr Moser); the Department of Pathology, University of Texas Health Science Center, San Antonio (Drs Olson and Higgins); the Department of Pathology, University of Alabama at Birmingham (Dr Pham); and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California (Dr Volod).

Context.—: The College of American Pathologists (CAP) developed proficiency testing for platelet function assays by using blood collected by the participant added to challenge tubes containing either saline (normal) or tirofiban (abnormal).

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2017-0556-CPDOI Listing

In Reply.

Authors:
Vicki J Schnadig

Arch Pathol Lab Med 2019 Apr;143(4):415-416

Department of Pathology, University of Texas Medical Branch, Galveston.

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http://dx.doi.org/10.5858/arpa.2018-0512-LEDOI Listing

Thyroid Cancer Overdiagnosis and Malpractice Climate.

Arch Pathol Lab Med 2019 Apr;143(4):414-415

2  Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.5858/arpa.2018-0490-LEDOI Listing

Meaningful Value Added by Standardized, Internationally Validated, and Evidence-Based Pathology Data Sets for Cancer Reporting of Head and Neck Sites Coordinated by the International Collaboration on Cancer Reporting.

Arch Pathol Lab Med 2019 Apr;143(4):422-423

From the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills.

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http://dx.doi.org/10.5858/arpa.2018-0489-EDDOI Listing

Clear Cell Sarcoma of the Kidney.

Arch Pathol Lab Med 2019 Mar 27. Epub 2019 Mar 27.

From the Division of Anatomical Pathology, University of Cape Town, Cape Town, and the National Health Laboratory Service, Western Cape, South Africa (Drs Aldera and Pillay); the Department of Anatomical Pathology, Groote Schuur Hospital, Western Cape, South Africa (Dr Aldera); and the Department of Anatomical Pathology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa (Dr Pillay).

Clear cell sarcoma of the kidney is an uncommon malignant pediatric renal neoplasm that typically presents in the 2- to 3-year age group and has a propensity for aggressive behavior and late relapses. Histologically, this tumor exhibits a great diversity of morphologic patterns which can mimic most other pediatric renal neoplasms, often leading to confusion and misdiagnosis. Until recently, adjunct immunohistochemical and molecular genetic tests to support the diagnosis were lacking. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-035
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http://dx.doi.org/10.5858/arpa.2018-0353-RSDOI Listing
March 2019
2 Reads

Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies.

Arch Pathol Lab Med 2019 Mar 27. Epub 2019 Mar 27.

From the Departments of Pathology (Dr Sarode) and Genetics (Dr Robinson), University of Texas Southwestern Medical Center, Dallas.

Context.—: Immunohistochemical expression of mismatch repair (MMR) protein is a well-accepted method for routine screening for Lynch syndrome with relatively high sensitivity and specificity. Occasionally, however, immunohistochemistry (IHC) can yield an equivocal result with poor reproducibility and the potential for misdiagnosis. Read More

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http://dx.doi.org/10.5858/arpa.2018-0201-OADOI Listing

Surgical Pathology "Boot Camp": A Military Experience.

Arch Pathol Lab Med 2019 Mar 27. Epub 2019 Mar 27.

From the Department of Pathology and Laboratory Services, Brooke Army Medical Center, Fort Sam Houston, Texas.

Context.—: A common concern in pathology residency training is the variability with which incoming trainees have attained basic pathology competencies during undergraduate medical education. While multifactorial deficiencies are likely due to recent de-emphasis of dedicated pathology courses during preclinical training, accelerating the transition from medical student to pathology resident is critical-particularly in military practice where a greater degree of autonomy is required of recent graduates. Read More

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http://dx.doi.org/10.5858/arpa.2018-0318-EPDOI Listing

Practical Applications in Immunohistochemistry: An Immunophenotypic Approach to the Spleen.

Arch Pathol Lab Med 2019 Mar 27. Epub 2019 Mar 27.

From the Department of Pathology, Walter Reed National Military Medical Center, Bethesda Maryland (Dr Borch); the Department of Hematopathology, University of Virginia, Charlottesville (Dr Aguilera); the Department of Hematopathology, Joint Pathology Center, Silver Spring, Maryland (Drs Brissette and Auerbach); and the Department of Hematopathology, NeoGenomics, Aliso Viejo, California (Dr O'Malley).

Context.—: Even though immunohistochemistry is routinely used by pathologists, evaluation of immunohistochemistry in splenic lesions remains difficult for many. Classification of benign and splenic lesions often requires a combination of hematoxylin-eosin evaluation, immunophenotyping, and sometimes molecular testing. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-021
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http://dx.doi.org/10.5858/arpa.2018-0211-CPDOI Listing
March 2019
1 Read

Open-Top Light-Sheet Microscopy Image Atlas of Prostate Core Needle Biopsies.

Arch Pathol Lab Med 2019 Mar 20. Epub 2019 Mar 20.

From the Departments of Pathology (Drs Reder, True, and Liu and Ms McCarty) and Mechanical Engineering (Drs Glaser and Liu and Mr Chen), University of Washington, Seattle.

Context.—: Ex vivo microscopy encompasses a range of techniques to examine fresh or fixed tissue with microscopic resolution, eliminating the need to embed the tissue in paraffin or produce a glass slide. One such technique is light-sheet microscopy, which enables rapid 3D imaging. Read More

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http://dx.doi.org/10.5858/arpa.2018-0466-OADOI Listing

Plasmacytoid Urothelial Carcinoma: An Unusual Variant That Warrants Aggressive Management and Critical Distinction on Transurethral Resections.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Mangalore, Karnataka, India (Ms Sood); and the Departments of Pathology and Surgery (Urology), University of Chicago Medical Center, Chicago, Illinois (Dr Paner). Ms Sood is currently a rotating medical student in the Department of Pathology, University of Chicago Medical Center.

Plasmacytoid urothelial carcinoma (PUC) is a variant of infiltrating urothelial carcinoma that is characterized by tumor cells that have striking morphologic resemblance to and immunohistochemical overlap with plasma cells, and that harbors CDH1 mutation. Plasmacytoid urothelial carcinoma can be widely infiltrative and may permeate the urinary bladder in a linitis plastica-like manner and spread along the fascial planes and into the peritoneum. Compared with conventional urothelial carcinoma, PUCs have greater chance for higher-stage disease, surgical margin positivity, and metastasis at presentation that translate into its poorer outcome. Read More

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http://dx.doi.org/10.5858/arpa.2018-0139-RSDOI Listing
March 2019
1 Read

Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From the Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.

Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence of necrosis. Read More

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http://dx.doi.org/10.5858/arpa.2017-0506-RSDOI Listing

Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia (Dr Surrey); Peoria Tazewell Pathology Group, Peoria, Illinois (Dr Oakley); the Department of Pathology, University of North Carolina, Chapel Hill (Dr Merker); Biostatistics (Mr Long) and Proficiency Testing (Ms Vasalos), College of American Pathologists, Northfield, Illinois; Office of the Director, The Joint Pathology Center, Silver Spring, Maryland (Dr Moncur); and the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Kim).

Context.—: There has been a rapid expansion of next-generation sequencing (NGS)-based assays for the detection of somatic variants in solid tumors. However, limited data are available regarding the comparative performance of NGS and non-NGS assays using standardized samples across a large number of laboratories. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-039
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http://dx.doi.org/10.5858/arpa.2018-0394-CPDOI Listing
March 2019
5 Reads

Moving Beyond Gleason Scoring.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From the Department of Urology, The Methodist Hospital, Houston, Texas (Dr Miles); the Departments of Pathology & Immunology (Drs Ittmann and Wheeler and Mr Sayeeduddin) and Molecular and Cell Biology (Dr Rowley), Baylor College of Medicine, Houston, Texas; Instituto de Patologia e Investigacion, Asuncion, Paraguay (Dr Cubilla); Biostatistics/Epidemiology/Research Design (BERD) Core, Departments of Internal Medicine (Dr Lee) and Pathology and Laboratory Medicine (Drs Bu, Ding, Gao, and Ayala), University of Texas Health Sciences Center Medical School, Houston.

Context.—: The combination of grading and staging is the basis of current standard of care for prediction for most cancers. D. Read More

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http://dx.doi.org/10.5858/arpa.2018-0242-RADOI Listing
March 2019
3 Reads
2.838 Impact Factor

Essential Updates in Grading, Morphotyping, Reporting, and Staging of Prostate Carcinoma for General Surgical Pathologists.

Arch Pathol Lab Med 2019 Mar 13. Epub 2019 Mar 13.

From the Departments of Pathology (Drs Paner and Choy) and Surgery (Urology) (Dr Paner), University of Chicago, Chicago, Illinois; and the Departments of Pathology and Laboratory Medicine (Drs Gandhi and Amin) and Urology (Dr Amin), University of Tennessee Health Science Center, Memphis.

Context.—: Within this decade, several important updates in prostate cancer have been presented through expert international consensus conferences and influential publications of tumor classification and staging.

Objective. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-033
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http://dx.doi.org/10.5858/arpa.2018-0334-RADOI Listing
March 2019
3 Reads

Utility of Multistep Protocols in the Analysis of Sentinel Lymph Nodes in Cutaneous Melanoma: An Assessment of 194 Cases.

Arch Pathol Lab Med 2019 Mar 11. Epub 2019 Mar 11.

From the Department of Pathology and Laboratory Medicine at the University of Calgary in Calgary, Alberta, Canada.

Context.—: Currently, no universal protocol exists for the assessment of sentinel lymph nodes (SLNs) in cutaneous melanoma. Many institutions use a multistep approach with multiple hematoxylin-eosin (H&E) and immunohistochemical stains. Read More

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http://dx.doi.org/10.5858/arpa.2018-0316-OADOI Listing

Renal Medullary Carcinoma.

Arch Pathol Lab Med 2019 Mar 11. Epub 2019 Mar 11.

From the Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston.

Renal medullary carcinoma, also referred to as the seventh sickle cell nephropathy, typically affects young African Americans with sickle cell trait, or, less frequently, patients with sickle cell disease. The existence of renal medullary carcinoma without a concomitant hemoglobinopathy is a topic of controversy. The typical patient is a young male of African or Mediterranean descent, with hematuria and/or flank pain. Read More

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http://dx.doi.org/10.5858/arpa.2017-0492-RSDOI Listing
March 2019
3 Reads

Pathology of Gastrointestinal and Liver Complications of Hematopoietic Stem Cell Transplantation.

Arch Pathol Lab Med 2019 Mar 6. Epub 2019 Mar 6.

Faculté de médecine, département de biologie moléculaire, de biochimie médicale et de pathologie, Université Laval, Hôpital du Saint-Sacrement - CHU de Québec, Québec, Québec, Canada (Dr Mourad); the Department of Pathology, McGill University and McGill University Health Center, Montreal, Quebec, Canada (Drs Michel and Marcus).

Context.—: Despite advances in therapeutic and preventive measures, hematopoietic stem cell transplant recipients remain at risk of a variety of gastrointestinal and liver complications.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0282-RADOI Listing
March 2019
3 Reads

Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).

Arch Pathol Lab Med 2019 Mar 6. Epub 2019 Mar 6.

From the Department of Pathology, Kaohsiung Medical University Hospital (Drs Chen and Yang), and the Department of Pathology, School of Medicine, College of Medicine (Dr Yang), Kaohsiung Medical University, Kaohsiung, Taiwan.

Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a rare, recently recognized entity restricted to the sinonasal tract. By definition, it is associated with high-risk HPV infection, particularly with HPV type 33. In most cases, tumors are composed of dual cell populations, including predominant basaloid myoepithelial cells and usually inconspicuous ductal cells. Read More

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http://dx.doi.org/10.5858/arpa.2018-0027-RSDOI Listing
March 2019
1 Read

SATB2 Versus CDX2: A Battle Royale for Diagnostic Supremacy in Mucinous Tumors.

Arch Pathol Lab Med 2019 Mar 6. Epub 2019 Mar 6.

From the Department of Pathology, University of New Mexico School of Medicine, Albuquerque (Drs Brettfeld, Ramos, Martin, and Hanson); and the Department of Pathology, Cleveland Clinic, Cleveland, Ohio (Dr Berry).

Context.—: Metastatic mucinous tumors present a diagnostic challenge for pathologists as tumor histomorphology is often nonspecific and optimal immunoprofiles are still under investigation.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0337-OADOI Listing

Social Media Use for Pathologists of All Ages.

Arch Pathol Lab Med 2019 Mar;143(3):282-286

From the Departments of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock (Dr Gardner). Dr McKee is retired from Brigham and Women's Hospital, Boston, Massachusetts and currently lives in Boussais, France.

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http://dx.doi.org/10.5858/arpa.2018-0431-EDDOI Listing

Next-Generation Microscopy: Optical Imaging for In Vivo and Ex Vivo Microscopy in Pathology.

Authors:
Lida P Hariri

Arch Pathol Lab Med 2019 Mar;143(3):287

From the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.5858/arpa.2018-0564-EDDOI Listing

Erratum.

Authors:

Arch Pathol Lab Med 2019 Mar;143(3):277

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http://dx.doi.org/10.5858/1543-2165-143.3.277DOI Listing

In Reply.

Arch Pathol Lab Med 2019 Mar;143(3):279-280

Department of Pathology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.5858/arpa.2018-0492-LEDOI Listing

Papillary Immature Metaplasia and Thin High-Grade Squamous Intraepithelial Lesion Originate in Early Metaplastic Epithelium of the Cervix.

Arch Pathol Lab Med 2019 Mar;143(3):279

Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.5858/arpa.2018-0271-LEDOI Listing

The Biospecimen Preanalytical Variables Program: A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland (Drs Carithers, Guan, Odeh, Sachs, Branton, and Moore);Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland (Drs Agarwal, Barcus, Lih, Williams, Sobin, Roche, and Mr Soria);Preferred Solutions Group, Preferred Scientific Group, Washington, District of Columbia (Dr Engel);Kelly Government Solutions, Kelly Services, Rockville, Maryland (Dr Greytak and Mr Fombonne);the Department of Pathology, University of New Mexico, Albuquerque (Dr Bocklage);the Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, Massachusetts (Dr Andry and Ms Duffy);the Department of Pathology and Laboratory Medicine, Emory University, Winship Cancer Institute, Atlanta, Georgia (Dr Sica);the Department of Pathology, University of Pittsburg, Pittsburgh, Pennsylvania (Dr Dhir);and Van Andel Research Institute, Pathology and Biorepository Core, VARI Core Technologies and Services, Grand Rapids, Michigan (Dr Jewell).

Context.—: Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing remain largely unknown.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0172-OADOI Listing
February 2019

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019
2 Reads

Streamlining Quality Review of Mass Spectrometry Data in the Clinical Laboratory by Use of Machine Learning.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Division of Laboratory Medicine, Department of Pathology, University of Virginia School of Medicine and Health System, Charlottesville. Dr Yu is currently located in the Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington.

Context.—: Turnaround time and productivity of clinical mass spectrometric (MS) testing are hampered by time-consuming manual review of the analytical quality of MS data before release of patient results.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0238-OADOI Listing
February 2019

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.

Authors:
Natalia Buza

Arch Pathol Lab Med 2019 Jan;143(1):47-64

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Read More

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http://dx.doi.org/10.5858/arpa.2018-0289-RADOI Listing
January 2019

Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes.

Arch Pathol Lab Med 2019 Jan;143(1):34-46

From the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada (Dr Hodgson); and the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Park).

Context.—: Cervical adenocarcinomas are a heterogeneous group of tumors with varying morphologies, etiologies, molecular drivers, and prognoses, comprising approximately 25% of all cervical cancers. Unlike cervical squamous cell carcinoma, adenocarcinomas are not uniformly caused by high-risk human papillomavirus (HPV) infection and, therefore, would not necessarily be prevented by the HPV vaccine. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-025
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http://dx.doi.org/10.5858/arpa.2018-0259-RADOI Listing
January 2019
6 Reads

Tissue Continues to Be the Issue: Role of Histopathology in the Context of Recent Updates in the Radiologic Classification of Interstitial Lung Diseases.

Arch Pathol Lab Med 2019 Jan;143(1):30-33

From the Department of Pathology, Kaiser Permanente Santa Clara, Santa Clara, California (Dr Raparia); and the Department of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Palo Alto, California (Dr Raj).

Context.—: High-resolution computed tomography (HRCT) imaging has an increasingly important role in clinical decision-making in patients with interstitial lung diseases. The recent Fleischner Society white paper on the diagnostic criteria for idiopathic pulmonary fibrosis highlights the advances in our understanding of HRCT imaging in interstitial lung diseases. Read More

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http://dx.doi.org/10.5858/arpa.2018-0134-RADOI Listing
January 2019

Understanding the Pathology Job Market: An Analysis of 2330 Pathology Job Advertisements From 2013 Through 2017.

Arch Pathol Lab Med 2019 Jan;143(1):9-10

1  Department of Pathology, The Ohio State University Medical Center, Columbus (Dr Zynger).

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http://dx.doi.org/10.5858/arpa.2018-0388-LEDOI Listing
January 2019
2.838 Impact Factor

Borderline Brenner Tumor: A Review of the Literature.

Arch Pathol Lab Med 2019 Feb 19. Epub 2019 Feb 19.

From the Department of Pathology, Rutgers-New Jersey Medical School, Newark, New Jersey.

Brenner tumors arise from ovarian epithelium, accounting for approximately 5% of benign ovarian epithelial tumors. The World Health Organization classification groups them into benign, borderline, and malignant on the basis of proliferation and invasiveness, and borderline Brenner tumor is defined as "displaying epithelial proliferation beyond that seen in benign Brenner's tumor, but lacking stromal invasion." Borderline Brenner tumors are rare. Read More

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http://dx.doi.org/10.5858/arpa.2018-0285-RSDOI Listing
February 2019

Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study.

Arch Pathol Lab Med 2019 Feb 19. Epub 2019 Feb 19.

From the Gynecological Oncology Unit (Drs Sopracordevole and del Fabro and Ms Buttignol).

Context.—: A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close (<1 mm) negative endocervical margin.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0363-OADOI Listing
February 2019

High-Grade Sinonasal Carcinoma: Classification Through Molecular Profiling.

Arch Pathol Lab Med 2019 Feb 19. Epub 2019 Feb 19.

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

High-grade sinonasal carcinomas are a cohort of malignant epithelial neoplasms arising in the sinonasal cavities with distinct, ominous morphologic features or lacking well-differentiated features that might otherwise classify them as less biologically worrisome. Recent advances in molecular profiling have led to the identification of several distinct tumor entities previously grouped together. These molecularly distinct lesions include NUT (midline) carcinoma, INI1 ( SMARCB1)-deficient carcinoma, SMARCA4-deficient sinonasal carcinoma, and novel IDH-mutant sinonasal undifferentiated carcinoma, in addition to the previously described lymphoepithelial carcinoma that may also be included in the differential diagnosis. Read More

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http://dx.doi.org/10.5858/arpa.2018-0224-RSDOI Listing
February 2019

Comparative Evaluation of Seegene Allplex Gastrointestinal, Luminex xTAG Gastrointestinal Pathogen Panel, and BD MAX Enteric Assays for Detection of Gastrointestinal Pathogens in Clinical Stool Specimens.

Arch Pathol Lab Med 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea (Drs Yoo, J. Park, H. K. Lee, and Y.-J. Park); the Department of Laboratory Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea (Mss Yu and K. G. Park and Mr G. D. Lee); and the Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge (Ms Oak).

Context.—: Infectious gastroenteritis is caused by various pathogens, including bacteria, viruses, and parasites.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0002-OADOI Listing
February 2019
1 Read

Development of Functional Requirements for Ex Vivo Pathology Applications of In Vivo Microscopy System: A Proposal From the In Vivo Microscopy Committee of the College of American Pathologists.

Arch Pathol Lab Med 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Pathology and Laboratory Medicine Service, VA Medical Center, Kansas City, Missouri (Dr Mathur); the Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio (Dr Fitzmaurice); the Department of Pathology, University of Washington, Seattle (Dr Reder); the Department of Pathology, University of Texas MD Anderson Cancer Center, Houston (Dr Krishnamurthy); Clinical Informatics, College of American Pathologists, Northfield, Illinois (Ms Kennedy); the Department of Pathology, Massachusetts General Hospital, Boston (Dr Tearney); and the Department of Pathology and Laboratory Medicine, Weil Cornell Medical College, New York, New York (Dr Shevchuk-Chaban).

Context.—: In vivo microscopy (IVM) allows direct, real-time visualization of tissue histology in living patients, without the need for tissue removal, processing, or staining. The IVM technologies in clinical use include confocal microscopy and optical coherence tomography. Read More

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http://dx.doi.org/10.5858/arpa.2018-0482-OADOI Listing
February 2019

Pulmonary Nodular Lymphoid Hyperplasia.

Arch Pathol Lab Med 2019 Feb 6. Epub 2019 Feb 6.

and the Department of Pathology, University of Texas Southwestern Biocenter, Dallas (Dr Rosado).

Pulmonary nodular lymphoid hyperplasia is an uncommon reactive lymphoproliferative disorder that presents as an asymptomatic lung mass. The histopathologic diagnosis of pulmonary nodular lymphoid hyperplasia may be challenging because of its morphologic overlap with other diseases, such as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and immunoglobulin G4-related sclerosing disease. Despite the similarities, there are distinctive morphologic and phenotypic features that allow for the correct diagnosis in the majority of cases. Read More

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http://dx.doi.org/10.5858/arpa.2018-0188-RSDOI Listing
February 2019
2 Reads

Protein C Deficiency.

Arch Pathol Lab Med 2019 Jan 31. Epub 2019 Jan 31.

From the Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri. Dr Moser is now with the Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City.

Protein C (PC) deficiency is a heritable or acquired risk factor for thrombophilia, with presentations varying from asymptomatic to venous thromboembolism to neonatal purpura fulminans, a life-threatening disorder. Hereditary PC deficiency is caused by mutation in the PC ( PROC) gene located on chromosome 2q14.3. Read More

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http://dx.doi.org/10.5858/arpa.2017-0403-RSDOI Listing
January 2019
5 Reads

The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outccomes: An Institutional Experience, Systematic Review, and Meta-analysis.

Arch Pathol Lab Med 2019 Jan 31. Epub 2019 Jan 31.

From the Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, Pennsylvania (Drs Luo, Khurana, Jhala, and Wang); and Clinical Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania (Dr Zhao).

Context.—: Recent studies and a few reviews suggest that presence of invasive cribriform lesions (ICLs) in prostatic acinar adenocarcinoma correlates with adverse outcomes. However, a systematic review with meta-analysis on this correlation is currently lacking. Read More

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http://dx.doi.org/10.5858/arpa.2017-0582-RADOI Listing
January 2019
1 Read