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Z Orthop Unfall 2020 Jan 9. Epub 2020 Jan 9.

Department for Trauma Surgery, Otto-von-Guericke University, Magdeburg Medical Faculty.

Background: Talar neck and body fractures are rare. Major posttraumatic complications with a potential reduction in the quality of life are arthrosis and necrosis due to the specific vascular supply. The aim of the study was to evaluate mid-term results of surgery for talar fractures of neck and body. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Dec 6;47(6):425-438. Epub 2019 Dec 6.

Section of Medical Genetics (PennGen), University of Pennsylvania.

In feline practice, blood groups were considered unimportant until the 1980s. Since then much has been learned. The most important blood group system in cats is the (renamed here as ) blood group system consisting of blood types , and (better referred to as ). Read More

Dtsch Med Wochenschr 2019 11 21;144(23):1642-1649. Epub 2019 Nov 21.

Medizinische Klinik I, Nephrologie; Universitätsklinikum Würzburg.

Due to the associated risk of stroke, non-valvular atrial fibrillation (nvAF) is a major indication for oral anticoagulation. Many patients suffer from chronic kidney disease (CKD), which increases the risk for stroke and for bleeding. Vitamin K antagonists (VKA) receive only cautious recommendations in guidelines for patients with CKD and nvVHF due to heterogeneous study results; their summaries of product characteristics contain contraindications for patients with manifest CKD. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Oct 18;47(5):313-320. Epub 2019 Oct 18.

Institut für Tierpathologie, Freie Universität Berlin.

Objective: In the literature, the BRAF mutation is reported to have been identified in 80 % of the examined canine prostate carcinomas (PCa). The objectives of this study were to test for the BRAF mutation in canine PCa in our cohort of canine patients, to determine the specificity and sensitivity of the test for this mutation, as well as to identify the association between the presence of the BRAF mutation and the histologic picture of PCa. Moreover, the method was to be established in cytology samples. Read More

J Am Geriatr Soc 2019 10 6;67(10):2186-2192. Epub 2019 Aug 6.

Institut für Arbeiten Lernen Altern, Bochum, Germany.

Background/objectives: Most forms of dementia are associated with progressive cognitive and noncognitive impairments that can severely affect fitness to drive. Whether safe driving is still possible in the single case, however, is often difficult to decide and may be dependent on both severity and type of the respective dementia syndrome. Particularly in early disease stages, Alzheimer disease dementia (ADD) and different types of non-Alzheimer dementias, such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson disease dementia (PDD), might differentially affect fitness to drive. Read More

Psychiatr Prax 2019 Sep 28;46(6):338-341. Epub 2019 May 28.

Zentrum Psychiatrische Rehabilitation, Universitäre Psychiatrische Dienste Bern, Schweiz.

Objective: This study reports on the evaluation of the Bern Job Coach Placement program, a supported employment intervention, in the routine operation.

Methods: Administrative data of participants from the years 2005 to 2016 were analysed in terms of integration into the general labour market and in terms of achieving a regular job.

Results: 46 percent of all participants (N = 420) were able to achieve the primary outcome of being integrated into the general labour market and 33 percent achieved a regular job. Read More

Rehabilitation (Stuttg) 2018 Dec 21;57(6):335-336. Epub 2018 Dec 21.

das vorliegende Heft beschäftigt sich dieses Mal mit einem heterogenen Bündel von Arbeiten zur Rehabilitation. Der Rehabilitationsbedarf steigt, gerade durch den demographischen Wandel kommen erhebliche Anforderungen auf die Rehabilitation zu. Umso problematischer ist es, dass es zunehmend erkennbar zu erheblichem Fachkräftemangel in den Rehabilitationseinrichtungen kommt. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

Laryngorhinootologie 2018 04 22;97(4):246-254. Epub 2018 Jan 22.

Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Hals-Chirurgie der Ruhr-Universität Bochum.

Introduction: Due to the demographic changes neurocognition has become an important issue also in the field of hearing rehabilitation.

Background: The present study aimed to evaluate the feasibility of a neurocognitive test using computer based tasks with regard to the elderly with and without hearing loss and its practicability for the daily clinical ENT setting.

Patients: 171 patients of both genders with normal hearing or a profound hearing loss were enrolled in the study: 90 middleaged persons were between 50 and 64 years (57. Read More

Aktuelle Urol 2017 May 20;48(3):243-247. Epub 2017 Apr 20.

Technische Universität München.

National and international guidelines recommend fosfomycin trometamol, nitrofurantoin, nitroxoline, and pivmecillinam as first-line agents for the treatment of acute uncomplicated cystitis. is by far the leading cause of community-acquired urinary tract infections. Pivmecillinam (X-SYSTO) is an oral prodrug of mecillinam, a penicillin derivative that was reintroduced to the German market in March 2016. Read More

J Dtsch Dermatol Ges 2017 Feb;15(2):151-158

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

Die Necrobiosis lipoidica ist eine seltene granulomatöse Erkrankung von bisher unzureichend geklärter Ätiologie. Häufig stellt die bei Diabetikern gehäuft zu beobachtende und zur Ulzeration neigende Dermatose eine starke Belastung für die Patienten dar. Bezüglich der Therapie existieren aktuell keine deutschen oder europäischen Leitlinien. Read More

J Dtsch Dermatol Ges 2016 Oct;14(10):995-1006

Institut für Sozialmedizin, Medizinische Fakultät, Universität Belgrad, Belgrad, Serbien.

Hintergrund Und Ziele: Die meisten früheren Arbeiten zu den klinisch-epidemiologischen Merkmalen von bullösen Autoimmunerkrankungen (AIBD) konzentrierten sich vor allem auf eine einzige Krankheitsentität oder nur eine Krankheitsgruppe; nur in wenigen Studien wurde die Inzidenz verschiedener AIBD untersucht. Bei der vorliegenden Studie war es unser Ziel, das gesamte Spektrum der AIBD zu betrachten, die Inzidenz der häufigsten AIBD zu ermitteln und die zeitlichen Trends ihres Auftretens in Zentralserbien über einen Zeitraum von 20 Jahren zu untersuchen.

Methoden: Wir rekrutierten retrospektiv 1161 AIBD-Fälle, die in Zentralserbien von Januar 1991 bis Dezember 2010 neu diagnostiziert wurden. Read More

J Dtsch Dermatol Ges 2016 Oct;14(10):1007-1015

Klinik für Nuklearmedizin, Klinikum Bremen-Mitte, Bremen.

Hintergrund: Kardiale Komorbiditäten bei Patienten mit Psoriasis stehen seit Jahren im Fokus. Ziel dieser Arbeit war es, im Rahmen einer Pilotstudie die Myokardszintigraphie als mögliche Früherkennungsmethode zu evaluieren.

Patienten Und Methodik: Es wurden bei insgesamt 50 kardial asymptomatischen Patienten mit einer Psoriasis der Haut verschiedene Begleiterkrankungen erfasst. Read More

Z Evid Fortbild Qual Gesundhwes 2016 8;110-111:77-84. Epub 2016 Jan 8.

Johann Wolfgang Goethe-Universität Frankfurt/Main, Dekanat des Fachbereichs Medizin, Deutschland. Electronic address:

The poor quality of medical dissertations has repeatedly been criticized by scientific and higher education institutions. In medicine, doctoral students rated their own knowledge of fundamental scientific issues as low. The establishment of a doctoral research program could solve this problem. Read More

Z Evid Fortbild Qual Gesundhwes 2016 12;110-111:69-76. Epub 2016 Jan 12.

Johann Wolfgang Goethe-Universität Frankfurt/Main, Institut für Allgemeinmedizin, Deutschland.

In Germany, medical doctorates are regularly criticized for their insufficient quality. In order to improve the quality of doctorates and to support doctoral candidates, a department-wide doctoral research program was established at the Goethe University of Frankfurt am Main in 2011 taking into account the practical needs of doctoral students at the School of Medicine. The program development proceeded in several steps: in the first step (2009/2010), a pilot study with eleven doctoral candidates was carried out at the Institute of General Practice. Read More

Clin Anat 2015 01 19;28(1):5-11. Epub 2014 Apr 19.

Department of Anatomical Sciences, School of Medicine, St. George's University, Grenada, West Indies.

Heinrich Obersteiner (1847-1921) was amongst the most influential neuroscientists in the 19th century. Born into a family of physicians, he gained early exposure to medicine, and as a medical student, he focused much of his research in neuroanatomy, eventually becoming a professor of neuroanatomy at the University of Vienna. Throughout his academic career, he focused greatly on neuropathology, and incorporated much of his research into his textbook, "Introduction to the Study of the Structure of the Central Nervous Organs in Health and Disease," which was considered the foremost reference text of neurology for many generations of scholars. Read More

Viszeralmedizin 2014 Feb;30(1):61-4

Klinik für Chirurgie - Viszeral- und Gefäßchirurgie, Vivantes-Humboldt-Klinikum, Berlin, Deutschland.

Hintergrund: Die pyloruserhaltende Pankreaskopfresektion (PPPD) ist als onkologisches Standardverfahren etabliert. Lokal fortgeschrittene Tumoren können eine erweiterte Resektion erforderlich machen. Ebenso soll früheren Arbeiten zufolge bei Tumornachweis in den parapylorischen Lymphknoten (PLK) eine distale Magenresektion im Sinne einer klassischen Whipple-Operation indiziert sein. Read More

Rehabilitation (Stuttg) 2010 Apr 5;49(2):66-79. Epub 2010 May 5.

Hochschule Magdeburg-Stendal, Angewandte Humanwissenschaften, Rehabilitationspsychologie.

There is growing evidence for the effectiveness of multimodal intervention concepts for chronic low back pain in the international literature, and accordingly several German rehabilitation programmes for the treatment of chronic low back pain patients have been developed. Focus of this paper is to describe and compare frequently used German multimodal intervention programmes for in- and outpatient rehabilitation of patients with chronic low back pain. Programmes were chosen by searching the most relevant online resources as well as the online pages of Deutsche Rentenversicherung and Zentrum Patientenschulung during September 2008. Read More

Pflege Z 2008 Jan;61(1):24-6

Klinikum Ludwigshaffen als Krankenschwester Tätig-trainerin und Bewegungslehrerin zu Arbeiten.

Pharm Unserer Zeit 2007 ;36(6):432-6

Rheinische Friedrich-Wilhelms Universität Bonn, LIMES Institut, Programmeinheit Chemische Biologie und Medizinische Chemie, c/o Kekulé Institut für Org. Chemie und Biochemie, Gerhard-Domagk-Str. 1, 53121 Bonn.

Kombinatorische biochemische Methoden ermöglichen die Identifikation von Nukleinsäuren, so genannten Aptameren, die hoch affin und spezifisch an Zielmoleküle binden und deren biologische Funktionen effektiv inhibieren. Deshalb repräsentieren Aptamere eine viel versprechende Klasse neuartiger Therapeutika. Untermauert wird dies vor allem durch die Zulassung von Pegaptanib (Macugen) zur Behandlung der altersbedingten Makuladegeneration (AMD), dem ersten Aptamer-basierten Medikament. Read More

Forsch Komplementarmed 1998 Apr;5(2):76-77

Radiologe 1997 Apr;37(4):278-84

Institut für Klinische Radiologie, Klinikum der Stadt Mannheim, Fakultät für Klinische Medizin Manneheim der Universität Heidelberg.

Introduction: Different concepts and applications of teleradiology systems have been realised. However, their cost-effectiveness is still questionable. Therefore, a cost-benefit analysis of three different scenarios of the new teleradiology system Kamedin (Kooperatives Arbeiten und rechnergestützte Medizinische Diagnostik auf innovativen Netzen der Deutschen Telekom) was performed. Read More

Comput Methods Programs Biomed 1997 Mar;52(3):175-83

Institut für Medizinische Informatik, Medizinische Universität zu Lübeck, Germany.

The software system KAMEDIN (Kooperatives Arbeiten und MEdizinische Diagnostik auf Innovativen Netzen) is a multimedia telemedicine system for exchange, cooperative diagnostics, and remote analysis of digital medical image data. It provides components for visualisation, processing, and synchronised audio-visual discussion of medical images. Techniques of computer supported cooperative work (CSCW) synchronise user interactions during a teleconference. Read More

Medinfo 1995 ;8 Pt 2:1511-4

Institut für Medizinische Informatik, Medizinische Universität zu Lübeck, Germany.

This contribution describes the software system KAMEDIN (Kooperatives Arbeiten und MEdizinische Diagnostik auf Innovativen Netzen) that is designed as an ISDN based computer supported cooperative work (CSCW) tool for usage in medical diagnostics. Medical image data from various sources (for example CT and MR) can be interchanged and analyzed in bilateral teleconferences via ISDN. During a cooperative session, user interactions for image processing etc. Read More

J Anim Breed Genet 1993 Jan;110(1-6):161-70

Agriculture and Forestry, The University of Melbourne, Parkville, Vic., 3052, Australia.

Summary: We have provided a bridge between geneticists, who tend to concentrate on genes and their frequencies, and other biologists, who are much more aware of how severely the environment constrains and limits life. This bridge is the recognition that a . fitness is a product of important component traits, b . Read More

Zentralbl Bakteriol Mikrobiol Hyg A 1988 Jun 8;268(4):560-579. Epub 2011 Nov 8.

Kagakushi Kenkyu 1984 ;23(151):169-76

Zentralbl Bakteriol Mikrobiol Hyg A 1983 Nov 15;255(4):566-576. Epub 2012 Mar 15.

Am J Psychiatry 1983 Jun;140(6):740-5

Biopsychosocial eclecticism is incomplete because it does not address the important issues of differential causation and treatment staging. Psychiatric serialism goes beyond eclecticism to consider biological, psychosocial, and existential-moral parameters as equipotential and hierarchical. What this means in practice is that, after forming a treatment alliance, the therapist must always assess the evidence for a biological substrate of disorder and, where feasible, administer the appropriate biological treatments. Read More

Am J Obstet Gynecol 1978 Nov;132(5):571-2