Arab J Sci Eng 2020 May 22:1-8. Epub 2020 May 22.
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh 522510 India.
A novel library of amide functionality having 1,2,4-thiadiazole-1,2,4-triazole () analogs was designed, synthesized, and structures were characterized by H NMR, C NMR, and mass (ESI-MS) spectral data. Further, all compounds were evaluated for their anticancer activities against four different cancer cell lines including breast cancer (MCF-7, MDA MB-231), lung cancer (A549), and prostate cancer (DU-145) by MTT reduction assay method, and etoposide acts as a standard drug. The results confirmed that majority of the synthesized compounds showed moderate to potent anticancer activities aligned with four cell lines. Read More