22,872 results match your criteria Arab journal of nephrology and transplantation[Journal]


Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function.

Hum Mutat 2018 Dec 6. Epub 2018 Dec 6.

Genome Research Division, Human Genetics department, Radboud University Medical Center Nijmegen and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Next-generation sequencing has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome and whole genome sequencing in 4 independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter and thinning of the corpus callosum, we identified 4 previously unreported homozygous truncating PPP1R21 alleles: c. Read More

View Article
December 2018

New variants in beta globin gene among the Palestinian refugees with sickle cell disease in Lebanon.

Saudi Med J 2018 Dec;39(12):1253-1258

Department of Biological Sciences, Beirut Arab University, Beirut, Lebanon. E-mail.

Objectives: To examine the association between beta-globin sequence variations and phenotypes of sickle-cell disease (SCD) complications among Palestinian refugees in Lebanon correlating them with chromatographic readings and co-inheritance with β-thalassemia traits.   Methods: This cross-sectional study included 47 Palestinian refugees aged 4 to 54 living in different regions in Lebanon during the year 2015. Participant filled a well-designed questionnaire. Read More

View Article
December 2018
2 Reads

Recent-onset of rheumatoid arthritis leads to increase in wall thickness of left anterior descending coronary artery. An evidence of subclinical coronary artery disease.

Saudi Med J 2018 Dec;39(12):1213-1217

Ministry of Health and Prevention, Dubai, United Arab Emirates. E-mail.

Objectives: To explore the atherosclerotic changes of the left anterior descending coronary artery (LADCA) in patients with early onset of rheumatoid arthritis (RA).

Methods: Transthoracic echocardiographic scans were performed on 15 early RA patients and 20 control subjects, free of rheumatological diseases, diabetes mellitus (DM), and cardiovascular disease (CVD). Out of 15 RA patients, 10 were matched for age and gender with control. Read More

View Article
December 2018
0.554 Impact Factor

Thyroid malignancy among patients with thyroid nodules in the United Arab Emirates: a five-year retrospective tertiary Centre analysis.

Thyroid Res 2018 30;11:17. Epub 2018 Nov 30.

6Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.

Objectives: Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy. Read More

View Article
November 2018

Diabetes and depression in Lebanon and association with glycemic control: a cross-sectional study.

Diabetes Metab Syndr Obes 2018 8;11:717-728. Epub 2018 Nov 8.

Department of Internal Medicine, Faculty of Medicine, Beirut Arab University, Beirut, Lebanon,

Background: Diabetes mellitus is a chronic noncommunicable disease characterized by hyperglycemia and is associated with chronic complications affecting the overall quality of life. As of 2017, the prevalence of diabetes in Lebanon is estimated to be 14.6%. Read More

View Article
November 2018
1 Read

Novel Betulin Derivative is Responsible for the Anticancer Folk Use of Ziziphus spina-christi from the Hot Environmental Habitat of UAE.

J Ethnopharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates, Research Institutes of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates.

Ethnopharmacological Relevance: Several natural products derived from plant sources are developed to remarkable medicines based on their traditional uses. Ziziphus, a worldwide known plant, is proven for potential cytotoxic activity. However, the plant growing at the unique hot environmental climate of UAE was never investigated. Read More

View Article
November 2018
1 Read

Correlates of nurses' motivation and their demographic characteristics.

Nurs Forum 2018 Dec 3. Epub 2018 Dec 3.

Hematopoietic Stem Cell Transplantation, Comprehensive Cancer Center, King Fahad Medical City (KFMC), Riyadh, Saudi Arabia.

Background: Motivation is a significant concern for workforce management in healthcare organizations as it is linked to many important factors, such as performance, staff retention, and satisfaction.

Aim: To assess motivation level, assess sources of motivation, and identify the difference in motivation level in relation to nurses' characteristics.

Setting: The study was carried out in one major tertiary hospital in Riyadh, Kingdom of Saudi Arabia. Read More

View Article
December 2018

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

PLoS Genet 2018 Dec 3;14(12):e1007833. Epub 2018 Dec 3.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense single nucleotide polymorphism (SNP) data in 2861 PBC cases and 8514 controls to impute classical HLA alleles and amino acid polymorphisms using state of the art methodologies. Read More

View Article
December 2018

Squatting versus squatting with hip adduction in management of patellofemoral osteoarthritis: A randomized controlled trial.

J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.

Department of Physical Therapy, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.

Background: Patellofemoral osteoarthritis is a common presentation in the outpatients' physical therapy clinics. The muscle imbalance between the vastus medialis oblique and vastus lateralis muscles is one of the main factors that lead to the development of this condition.

Objective: To compare the effect of a squatting versus squatting with hip adduction in management of patellofemoral osteoarthritis. Read More

View Article
November 2018
4 Reads

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals.

Clin Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Italy.

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. Read More

View Article
December 2018
2 Reads

A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images.

J Digit Imaging 2018 Nov 30. Epub 2018 Nov 30.

Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates.

We address the problem of prostate lesion detection, localization, and segmentation in T2W magnetic resonance (MR) images. We train a deep convolutional encoder-decoder architecture to simultaneously segment the prostate, its anatomical structure, and the malignant lesions. To incorporate the 3D contextual spatial information provided by the MRI series, we propose a novel 3D sliding window approach, which preserves the 2D domain complexity while exploiting 3D information. Read More

View Article
November 2018
1 Read

Robotic totally endoscopic coronary artery bypass grafting (TECAB) of the left anterior descending and right coronary artery system using an arterial Y-graft technique.

Ann Cardiothorac Surg 2018 Sep;7(5):700-703

Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

View Article
September 2018
3 Reads

The Pulse in Medieval and Arab-Islamic Medicine: Part 2.

Authors:
Rachel Hajar

Heart Views 2018 Apr-Jun;19(2):76-80

Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

View Article
December 2018

Fungal Planet description sheets: 716-784.

Persoonia 2018 Dec 13;40:240-393. Epub 2018 Jul 13.

Westerdijk Fungal Biodiversity Institute, P.O. Box 85167, 3508 AD Utrecht, The Netherlands.

Novel species of fungi described in this study include those from various countries as follows: , on leaf litter, from × hybrid, on subsp. on on on sp., on sp. Read More

View Article
December 2018
2 Reads

An unusual postoperative complication in a thoracic spinal extradural arachnoid cyst.

Neurol India 2018 Nov-Dec;66(6):1837-1839

Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

View Article
December 2018
1 Read

Critical Care Nurses' Reasons for Working or Not Working Overtime.

Crit Care Nurse 2018 Dec;38(6):47-57

Vanessa M. Lobo develops workshops for clinicians and teaches in Health Organization Management at the Canadian University Dubai, Dubai, United Arab Emirates. Jenny Ploeg is a professor in the School of Nursing and associate member, Department of Health, Aging and Society, McMaster University, Hamilton, Ontario. She is scientific director of the Aging, Community and Health Research Unit, School of Nursing, McMaster University. Anita Fisher is an associate professor in the School of Nursing, Faculty of Health Science at McMaster University. Gladys Peachey is retired from the faculty of Nursing at McMaster University. Noori Akhtar-Danesh is an associate professor of biostatistics, School of Nursing, McMaster University.

Background: Around the world, registered nurses are working increasing amounts of overtime. This is particularly true in critical care environments, which experience unpredictable fluctuations in patient volume and acuity, combined with a need for more specialized nurses.

Objective: To explore critical care nurses' reasons for working or not working overtime. Read More

View Article
December 2018

Characterization of PI3KCA and BRAF mutations in gastric adenocarcinoma: An approach to a personalized targeted therapy for Moroccan HER2 overexpressed patients.

Arab J Gastroenterol 2018 Nov 28. Epub 2018 Nov 28.

Laboratory of Anatomy Pathology, Pasteur Institue, 20100, Morocco.

Background And Study Aims: Targeted therapies have an increasing importance in digestive oncology. To our knowledge, we are the first to report the distribution of PI3KCA and BRAF mutations in Moroccan HER2 overexpressed patients, in order to introduce targeted therapy in the arsenal of therapeutic modalities for management in Morocco.

Patients And Methods: 98 gastric adenocarcinoma tissue samples were collected. Read More

View Article
November 2018

Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada.

Aims: To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events.

Methods And Results: We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7. Read More

View Article
December 2018
1 Read

Instruments for augmentative and alternative communication for children with autism spectrum disorder: a systematic review.

Clinics (Sao Paulo) 2018 Nov 29;73:e497. Epub 2018 Nov 29.

Laboratorio de Delineamento de Estudos e Escrita Cientifica, Faculdade de Medicina do ABC (FMABC), Santo Andre, SP, BR.

New technologies designed to improve the communication of autistic children can also help to promote interaction processes and cognitive and social development. The aim of this study was to analyze the instruments used to improve the communication skills of children with autism spectrum disorder. We searched the PubMed and Web of Science databases using the descriptors "autism", "Asperger", "education", "children" and "assistive technology" and selected articles that met the following inclusion criteria: (i) original research; (ii) written in English; (iii) based on participants with a primary diagnosis of autism spectrum disorder; and (iv) tested an instrument designed to promote communication in children with autism spectrum disorder. Read More

View Article
November 2018
1 Read

FranceCoag: a 22-year prospective follow-up of the national French cohort of patients with inherited bleeding disorders.

Eur J Epidemiol 2018 Dec 5. Epub 2018 Dec 5.

Haemophilia Treatment Centre, APHM, Children Hospital La Timone, Aix Marseille University, INSERM, INRA, C2VN, Marseille, France.

FranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project's progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3. Read More

View Article
December 2018
3 Reads

Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults.

Sci Rep 2018 Dec 4;8(1):17616. Epub 2018 Dec 4.

Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel.

Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. Read More

View Article
December 2018
1 Read

Perindopril-induced angioedema of the lips and tongue: a case report.

J Med Case Rep 2018 Dec 5;12(1):359. Epub 2018 Dec 5.

Pharmaceutical Care Department, Alansar Hospital, Al Madinah, Al Munawarah, Saudi Arabia.

Background: Ace inhibitor-induced angioedema, characterized by sudden-onset swelling of the mucous membrane, skin, or both, is a rare occurrence in the Kingdom of Saudi Arabia. Because of its safety and efficacy, perindopril is a commonly prescribed angiotensin-converting enzyme inhibitor. Here we describe the clinical manifestations, management, and outcome of perindopril-induced angioedema of the lips and tongue in a 65-year-old Saudi man. Read More

View Article
December 2018
1 Read

Mental health outcomes among Arab refugees, immigrants, and U.S. born Arab Americans in Southeast Michigan: a cross-sectional study.

BMC Psychiatry 2018 Dec 4;18(1):379. Epub 2018 Dec 4.

University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

Background: Arab refugees and immigrants living in the United States may be exposed to political, economic, social, and environmental stressors that may affect their mental health. Yet, little is known regarding mental health outcomes among Arab Americans. The purpose of this study was to measure depression and anxiety levels among Arabs in Southeast Michigan and determine whether these levels differ by resident status: refugee, immigrant, or U. Read More

View Article
December 2018
1 Read

Natural Negative Allosteric Modulators of 5-HT₃ Receptors.

Molecules 2018 Dec 3;23(12). Epub 2018 Dec 3.

Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, 13060 Kuwait.

Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT serotonin) receptors in the pathogenesis and treatment of CINV. 5-HT₃ receptors are members of ligand-gated ion channels that mediate the rapid and transient membrane-depolarizing effect of 5-HT in the central and peripheral nervous system. Read More

View Article
December 2018
1 Read

Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab Adolescents.

Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.

Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Vitamin D deficiency has been shown to affect iron status via decreased calcitriol production, translating to decreased erythropoiesis. The present study aimed to determine for the first time whether vitamin D supplementation can affect iron levels among Arab adolescents. A total of 125 out of the initial 200 Saudi adolescents with vitamin D deficiency (serum 25(OH)D < 50 nmol/L) were selected from the Vitamin D-School Project of King Saud University in Riyadh, Saudi Arabia. Read More

View Article
December 2018

Spatial simulation of the ecological processes of stormwater for sponge cities.

J Environ Manage 2018 Nov 30;232:574-583. Epub 2018 Nov 30.

School of Resources and Environment, Ningxia University, Yinchuan, 750021, China.

The ecological stormwater processes of a sponge city include the ecological processes of runoff and confluence, the thermal landscape and decontamination. In this study, elements of stormwater processes - short-duration heavy rainfall, rainstorm intensity, drainage networks, surface temperature, the scouring process and the cumulative process of pollutants (SS, COD, TP and NH3_N), and, finally, the low impact development (LID) facilities at different recurrence periods-are simulated using the rainstorm intensity model, the scoured exponential model and the split-window algorithm. Land-use types and LID facilities in sponge cities greatly influence the spatial distribution of ecological stormwater processes. Read More

View Article
November 2018

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Department of Biological Sciences and Technology, National University of Tainan, Tainan, Taiwan. Electronic address:

SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. Read More

View Article
December 2018
1 Read

Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury.

Food Funct 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Taif 21974, Saudi Arabia.

Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas species. The clinical use of gentamycin is substantially limited by its side effects particularly acute kidney injury (AKI). The aim of the current study was to investigate the protective effect of the plant flavonoid troxerutin (150 mg kg-1 day-1 for 15 days) against gentamycin-induced AKI using Wistar rats as an experimental mammalian model. Read More

View Article
December 2018
1 Read

Thin and crush: The new mantra in left main stenting?

World J Cardiol 2018 Nov;10(11):191-195

Interventional Cardiology, Thumbay Hospital, Ajman 415555, United Arab Emirates.

Complex bifurcations have been suggested to be better approached by a planned double stent technique; however, recent randomized trials have shown better outcomes of provisional compared to planned two-stent strategy, in terms of both short-term efficacy and safety. In left main (LM) bifurcations, double kissing (DK)-Crush has demonstrated its superiority over Culotte and provisional-T in terms of restenosis and stent thrombosis, gaining respect as one of the most performant techniques for bifurcations stenting. On the other hand, the Nano-Crush technique has recently become part of the repertoire of double stenting techniques, providing evidence that the use of ultrathin strut stents and very minimal crush would be beneficial for both the physiological and rheological properties of the complex bifurcations, even in LM scenario, leading to a lower rate of thrombosis and restenosis at both side branch and true carina. Read More

View Article
November 2018
1 Read

Evaluation of the role of gene in type 2 diabetes mellitus and hypertension in ethnic Saudi Arabs.

Saudi Pharm J 2018 Dec 20;26(8):1199-1203. Epub 2018 Jul 20.

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Background: Coronary heart disease (CAD) is a multiple with several contributory risk traits, including type 2 diabetes and hypertension, which may share common genetic risk variants with the disease. Genome-wide association studies (GWASs) have yielded a wealth of information suggesting that CAD, the extent of contributory variants may differ according to genetic locus. The present study aimed at verifying whether the cyclin-dependent kinase 4 inhibitor B () genomic region strongly associated with coronary artery disease (CAD)/myocardial infarction (MI) may also constitute risk for its risk factors type 2 diabetes mellitus (T2DM) and hypertension (HTN) in ethnic Saudi Arabs. Read More

View Article
December 2018
1 Read

Communication Between Dentists and Dental Technicians During the Fabrication of Removable Partial Dentures in Khartoum State, Sudan.

Acta Stomatol Croat 2018 Sep;52(3):246-253

Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.

Objectives: To investigate the quality of communication between dentists and dental laboratory technicians in private dental laboratories in Khartoum State related to fabrication of removable partial dentures.

Methods: This was a descriptive cross-sectional study, in which dental technicians were interviewed regarding the quality of instructions they received from dentists concerning the construction of removable partial dentures (RPD). Eighty cases were investigated, 69 acrylic (A-RPD) and 11 cobalt chromium (CC-RPD) dentures. Read More

View Article
September 2018
1 Read

A Trial Sequential Meta-analysis of α -308G>A (rs800629) Gene Polymorphism and Susceptibility to Colorectal Cancer.

Biosci Rep 2018 Dec 3. Epub 2018 Dec 3.

Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, Saudi Arabia

Purpose: Tumor necrosis factor-alpha (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of -α -308 G>A (rs1800629) single nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between -α -308 G>A gene polymorphism with CRC risk. Read More

View Article
December 2018

Highlights from Gastro Update Europe - Prague, June 2018.

Authors:
Guido N J Tytgat

Arab J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Division of Gastroenterology-Hepatology, Amsterdam UMC-location Academic Medical Center, Meibergdreef, 1105 AZ Amsterdam, Netherlands. Electronic address:

View Article
November 2018

Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases.

Arab J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Background And Study Aims: Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of most important gastro-duodenal diseases, such as gastritis, peptic ulcer disease (PUD) and gastric cancer. H. Read More

View Article
November 2018

The emergence emergency: A mudskipper's response to temperatures.

J Therm Biol 2018 Dec 11;78:65-72. Epub 2018 Sep 11.

ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4810, Australia.

Temperature has a profound effect on all life and a particularly influential effect on ectotherms, such as fishes. Amphibious fishes have a variety of strategies, both physiological and/or behavioural, to cope with a broad range of thermal conditions. This study examined the relationship between prolonged (5 weeks) exposure to a range of temperatures (22, 25, 28, or 32 °C) on oxygen uptake rate and movement behaviours (i. Read More

View Article
December 2018

Financial feasibility of waste to energy strategies in the United Arab Emirates.

Waste Manag 2018 Dec 26;82:207-219. Epub 2018 Oct 26.

Department of Civil and Environmental Engineering, University of Sharjah, Sharjah, United Arab Emirates.

The present research explores the financial feasibility of alternative waste management strategies, based on waste to energy, in the United Arab Emirates. The integrated strategies assessed in this study were primarily based on anaerobic digestion (AD) or incineration. The economics of both strategies were evaluated based on various revenue and cost streams, as well as multiple financial parameters over a 20-year period. Read More

View Article
December 2018

Research Pearls: Expert Consensus Based Evidence Using the Delphi Method.

Arthroscopy 2018 Dec;34(12):3278-3282

Alexandria, Virginia, U.S.A.

The evolution of a systematic approach to assessing pertinent investigations is known as evidence-based medicine (EBM). EBM is defined as the conscientious and judicious use of current best evidence from clinical care research and integration of clinical expertise in the management of individual patients. There is no doubt that EBM is important but may not give clinically meaningful guidance on topics with clinical equipoise for individual patient care. Read More

View Article
December 2018
4 Reads

Research Pearls: How Do We Establish the Level of Evidence?

Arthroscopy 2018 Dec;34(12):3271-3277

Heartland Orthopedic Associates, Alexandria, Minnesota, U.S.A.

Evidence-based medicine (EBM) guidelines were first introduced in 1986 and were defined as the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients. The practice of EBM means integrating individual clinical expertise with the best available external clinical evidence from systematic research. Level of evidence (LOE) stratifies publications from Level I to Level V and provides the foundation for EBM. Read More

View Article
December 2018

Regularization of deep neural networks with spectral dropout.

Neural Netw 2018 Oct 16;110:82-90. Epub 2018 Oct 16.

The Australian National University, Canberra ACT 0200, Australia. Electronic address:

The big breakthrough on the ImageNet challenge in 2012 was partially due to the 'Dropout' technique used to avoid overfitting. Here, we introduce a new approach called 'Spectral Dropout' to improve the generalization ability of deep neural networks. We cast the proposed approach in the form of regular Convolutional Neural Network (CNN) weight layers using a decorrelation transform with fixed basis functions. Read More

View Article
October 2018

Utilisation of Healthcare Services and Medicines by Pakistani Migrants Residing in High Income Countries: A Systematic Review and Thematic Synthesis.

J Immigr Minor Health 2018 Nov 29. Epub 2018 Nov 29.

School of Pharmacy, The University of Queensland, 20 Cornwall Street, Woolloongabba, Brisbane, QLD, 4102, Australia.

Migration, as a global phenomenon, gives rise to many challenges for healthcare professionals providing care to migrant populations. Migrants originating from diverse cultural backgrounds have unique beliefs and healthcare needs, and their utilisation of healthcare services and medicines is influenced by a number of factors. This review aims to assess the factors influencing the utilisation of healthcare services and medicines among Pakistani migrants residing in high income countries. Read More

View Article
November 2018

Spectral Domain Optical Coherence Tomography in Macular Diseases, Eds: Carsten H. Meyer, Sandeep Saxena, SriniVas R. Sadda 2017 443pp., ISBN: 978-81-322-3608-5 Springer India.

Authors:
Igor Kozak

Graefes Arch Clin Exp Ophthalmol 2018 Nov 29. Epub 2018 Nov 29.

Moorfields Eye Hospital Centre, Abu Dhabi, United Arab Emirates.

View Article
November 2018
4 Reads

Toothbrushing-Should We Advise Mechanical or Power Brushes? Results of an International Delphi Conference.

J Contemp Dent Pract 2018 Oct 1;19(10):1169-1173. Epub 2018 Oct 1.

Procter and Gamble Gulf, Dubai, United Arab Emirates.

Background And Aim: To develop evidence-based answers to a series of questions in relation to toothbrushing using a modified Delphi consensus approach. Oral hygiene and especially toothbrushing have been a fundamental part of the efforts to prevent caries and gingivitis. The questions discussed involved the frequency and duration of brushing, the effectiveness and safety of powered brushes and the recommendations for children and orthodontic patients. Read More

View Article
October 2018

In Vitro Assessment of Cytotoxicity and Estrogenicity of Vivera® Retainers.

J Contemp Dent Pract 2018 Oct 1;19(10):1163-1168. Epub 2018 Oct 1.

Department of Orthodontics, Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; Tel: +971 56 315 9378; e-mail:

Aim: To investigate the cytotoxicity and estrogenicity of Vivera® retainers by assessing their biological behavioral effects as-received from the manufacturer and after retrieved from patients.

Materials And Methods: In this, in vitro investigation six sets (maxillary and mandibular) of Vivera® retainers, three as received and three retrieved after four weeks of use by patients of an orthodontic postgraduate clinic, were immersed in the normal saline solution for 14 days following different modes of sterilization. The estrogenicity assays involved two cell lines, namely the estrogen-sensitive MCF-7 and the estrogen-insensitive MDA-MB-231. Read More

View Article
October 2018
3 Reads

A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway.

Pestic Biochem Physiol 2018 Nov 13;152:29-37. Epub 2018 Aug 13.

Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Chlorpyrifos (CPF) is an agricultural pesticide and a potential food contaminant, which causes neurotoxicity. Here, we aimed at exploring the link between the repeated exposure to CPF and memory dysfunction in rats and the possible protective effect of kaempferol, a flavonoid with appreciable antioxidant and anti-inflammatory activities. Rats were divided into: Control group (received drug vehicles for 14 days); CPF-treated group (received subcutaneous 18 mg/kg BW of CPF daily for 14 days and CPF + Kaempferol treated group (received the same CPF dose +21 mg/kg BW of Kaempferol intraperitoneally for 14 days. Read More

View Article
November 2018
1 Read

Prevalence of hypertension and prehypertension and its associated cardioembolic risk factors; a population based cross-sectional study in Alkharj, Saudi Arabia.

BMC Public Health 2018 Nov 29;18(1):1327. Epub 2018 Nov 29.

College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Mail Code 2350, P.O. Box 3660, Riyadh, 11481, Saudi Arabia.

Background: Hypertension and prehypertension pose significant public-health and clinical challenges for both economically developed and developing nations. Prevalence of these conditions are frequently underreported because of its often-silent nature. Population-based studies that explore the occurrence and correlates of these conditions are scarce in Saudi Arabia. Read More

View Article
November 2018

Children's Attitudes to Parental Mediation in a Traditional Society.

Authors:
Yehuda Peled

Cyberpsychol Behav Soc Netw 2018 Nov 29. Epub 2018 Nov 29.

1 Western Galilee College, Akko, Israel.

Since the 1980s there have been many reports on parental mediation of children's behavior, from TV watching to Internet surfing, but most of the data come from Western societies. Israeli Arab society is a traditional patriarchy, which is in a constant change. The use of handheld devices, mainly smartphones which enable Internet access, has become a status symbol, leading to challenges with parental control issues. Read More

View Article
November 2018
3 Reads

Systemic Lupus Erythematous: Symptoms and Signs at Initial Presentations.

Antiinflamm Antiallergy Agents Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Department, Ministry of Health and Prevention, PO Box 65522, Dubai. Saudi Arabia.

Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory condition that causes microvascular inflammation with the production of various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes, all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds. Asia encompasses people of many sociocultural backgrounds with diverse ethnic. Read More

View Article
November 2018
11 Reads

Two sisters with a rare cause of infantile colic.

Authors:
Yasser Negm

J Paediatr Child Health 2018 Nov 28. Epub 2018 Nov 28.

Department of Paediatrics, Emirates Hospital, Dubai, United Arab Emirates.

Introduction: Infantile colic is a major parenthood challenge. For medical practitioners, even at the highest specialised levels, the management is never less challenging. This is a case report of two sisters who presented with typical symptoms of infantile colic. Read More

View Article
November 2018
1 Read

Effect of Assorted Globin Haplotypes and α-Thalassemia on the Clinical Heterogeneity of Hb S-β-Thalassemia.

Hemoglobin 2018 Nov 29:1-7. Epub 2018 Nov 29.

e Department of Haematogenetics , National Institute of Immuno-Haematology , Parel, Mumbai , India.

Hemoglobinopathies and thalassemias are the most commonly encountered monogenic disorders of blood in humans, posing a major genetic and public health problem round the globe. Hb S (HBB: c.20A>T)-β-thalassemia (β-thal) is a compound aberrant heterozygosity with inconsistent phenotypic expression, which are poorly described and clinically mapped. Read More

View Article
November 2018
3 Reads