27,583 results match your criteria Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology[Journal]


Letter to the Editor: D-dimer and presumptive diagnosis of COVID-19.

Acad Emerg Med 2020 Jul 11. Epub 2020 Jul 11.

Royal College Emergency Residency Program and Emergency Department, Faculty of Medicine, McGill University, Montréal, Canada.

We read with interest, "D-dimer triage for COVID-19" by Chenghong et al. This observational cohort study from Wuhan, China concludes that a D-dimer done at admission could be an effective and easily available diagnostic surrogate marker for coronavirus disease-19 (COVID-19). We are concerned that several limitations in the study's methodology affect the authors' conclusions. Read More

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http://dx.doi.org/10.1111/acem.14085DOI Listing

A word of caution.

Clin Cardiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiology, Mediclinic Al Jowhara Hospital, Al Ain, United Arab Emirates.

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http://dx.doi.org/10.1002/clc.23420DOI Listing

Conflict-driven social change: the case of Syrian children and youth.

Authors:
Angela Veale

Curr Opin Psychol 2020 Jun 9;35:114-118. Epub 2020 Jun 9.

School of Applied Psychology, University College Cork, Ireland. Electronic address:

For Syrian children, the civil war which emerged as a consequence of the Arab Spring has driven massive social change both at the structural level of legal, socioeconomic, educational and health systems, and at the intimate heart of everyday family life. This paper reviews recent research to understand the nature and impact of conflict-driven social change on children's lives. Research from the region and Western resettlement contexts indicates that Syrian refugee children have experienced high levels of exposure to conflict-related traumatic events and elevated rates of mental health difficulties, with evidence to suggest that adolescent girls in the region exhibit poorer well-being than boys. Read More

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http://dx.doi.org/10.1016/j.copsyc.2020.06.001DOI Listing

Potential causes of male and female infertility in Qatar.

J Reprod Immunol 2020 Jun 28;141:103173. Epub 2020 Jun 28.

Department of Basic Medical Sciences, College of Medicine, Member of QU Health, Qatar University, Doha, Qatar. Electronic address:

A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the potential causes of infertility that are particularly prevalent in the Qatari population. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103173DOI Listing

The impact of the additional metformin to the treatment of endometrial hyperplasia without atypia in addition to progesterone in a randomized fashion, a placebo-controlled, double blind clinical trial.

J Gynecol Obstet Hum Reprod 2020 Jul 8:101863. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Endometrial hyperplasia (EH) is a premalignant neoplasm. Most recently, metformin has been suggested as an adjuvant medication for treating of EH with better outcome. Recent evidence has suggested that metformin has anticancer activity by inhibiting cell proliferation and tumor growth. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101863DOI Listing

River basin salinization as a form of aridity.

Proc Natl Acad Sci U S A 2020 Jul 10. Epub 2020 Jul 10.

Masdar Institute, Khalifa University of Science and Technology, PO Box 54224, Abu Dhabi, United Arab Emirates;

Soil-salinization affects, to a different extent, more than one-third of terrestrial river basins (estimate based on the Food and Agriculture Organization Harmonized World Soil Database, 2012). Among these, many are endorheic and ephemeral systems already encompassing different degrees of aridity, land degradation, and vulnerability to climate change. The primary effect of salinization is to limit plant water uptake and evapotranspiration, thereby reducing available soil moisture and impairing soil fertility. Read More

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http://dx.doi.org/10.1073/pnas.2005925117DOI Listing

COVID-19 in people living with diabetes: An international consensus.

J Diabetes Complications 2020 Jul 6:107671. Epub 2020 Jul 6.

Tulane University Medical Center, Tulane University Medical School, New Orleans, USA.

The COVID-19 pandemic has added an enormous toll to the existing challenge of diabetes care world-wide. A large proportion of patients with COVID-19 requiring hospitalization and/or succumbing to the disease have had diabetes and other chronic conditions as underlying risk factors. In particular, individuals belonging to racial/ethnic minorities in the U. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107671DOI Listing

Impact of a pain management program on nurses' knowledge and attitude toward pain in United Arab Emirates: Experimental-four Solomon group design.

Appl Nurs Res 2020 Aug 25;54:151314. Epub 2020 May 25.

Dubai Health Authority, Education Department, Dubai Hospital, Dubai, United Arab Emirates; Amana Health Care Medical and Rehabilitation Hospital, Abu Dhabi, United Arab Emirates; Collaborative Science and Innovation, Clinical Nurse Specialist and Nurse Scientist, Billings Clinic, MT, USA.

Background: Lack of knowledge about pain is a common barrier to effective pain management. Educational pain management programs directed to health care professionals can improve knowledge and attitudes about pain. However, changing practice is more challenging, but can be achieved with more targeted educational interventions within the clinical setting. Read More

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http://dx.doi.org/10.1016/j.apnr.2020.151314DOI Listing

Complementary and alternative medicine use among patients with type 2 diabetes living in the United Arab Emirates.

BMC Complement Med Ther 2020 Jul 10;20(1):216. Epub 2020 Jul 10.

Department of Clinical Nutrition and Dietetics, College of Health Sciences, Research Institute of Medical & Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.

Background: The use of Complementary and Alternative Medicine (CAM) among Type 2 Diabetes Mellitus (T2DM) patients is increasing to manage the complexities of their condition, enhance their health, and ease complications. The burden of T2DM in the United Arab Emirates (UAE) coupled with the high prevalence of CAM use and its associated risks among patients with T2DM necessitated the investigation of the use of CAM by this patients' population. The aim of this study is to examine the prevalence, types, and correlates of CAM use among T2DM patients in the UAE. Read More

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http://dx.doi.org/10.1186/s12906-020-03011-5DOI Listing

Challenges for cancer patients returning home during SARS-COV-19 pandemic after medical tourism - a consensus report by the emirates oncology task force.

BMC Cancer 2020 Jul 10;20(1):641. Epub 2020 Jul 10.

Department of Oncology - Alzahra Hospital - Dubai, United Arab Emirates and Department of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: The COVID-19 pandemic has caused a global health crisis. Numerous cancer patients from non-Western countries, including the United Arab Emirates (UAE), seek cancer care outside their home countries and many are sponsored by their governments for treatment. Many patients interrupted their cancer treatment abruptly and so returned to their home countries with unique challenges. Read More

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http://dx.doi.org/10.1186/s12885-020-07115-6DOI Listing

Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models.

Nutrients 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.

Nerolidol (NED) is a naturally occurring sesquiterpene alcohol present in various plants with potent anti-inflammatory effects. In the current study, we investigated NED as a putative anti-inflammatory compound in an experimental model of colonic inflammation. C57BL/6J male black mice (C57BL/6J) were administered 3% dextran sodium sulfate (DSS) in drinking water for 7 days to induce colitis. Read More

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http://dx.doi.org/10.3390/nu12072032DOI Listing

The Association of rs1898830 in with Lipids and Blood Pressure.

J Cardiovasc Dev Dis 2020 Jul 8;7(3). Epub 2020 Jul 8.

Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut 115020, Lebanon.

Background And Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. Read More

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http://dx.doi.org/10.3390/jcdd7030024DOI Listing

Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.

J Popul Ther Clin Pharmacol 2020 Jun 29;27(S Pt 1):e31-e36. Epub 2020 Jun 29.

Co-Editor-in-Chief - Journal of Population Therapeutics and Clinical Pharmacology, Brisbane, QLD, Australia.

The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. Read More

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http://dx.doi.org/10.15586/jptcp.v27iSP1.708DOI Listing

Coping among adolescents with long-term health conditions: a mixed-methods study.

Br J Nurs 2020 Jul;29(13):762-769

Associate Professor, Department of Nursing, University of Sharjah, United Arab Emirates (UAE), School of Nursing, Midwifery and Indigenous Health, Charles Sturt University, Australia, and Sharjah Institute for Medical and Health Research, University of Sharjah, UAE.

Background: Adolescents with long-term health conditions may be at risk of developing psychological comorbidities and adopting ineffective coping mechanisms if they are not adequately supported at home or school.

Aim: To understand the strategies adolescents use when dealing with challenging health situations, and gain an in-depth understanding of the characteristics of their preferred care environment if they have unexpected health crises.

Design: The study used a concurrent mixed-methods design, with data gathered between January and May 2019. Read More

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http://dx.doi.org/10.12968/bjon.2020.29.13.762DOI Listing

Ratite oils for local transdermal therapy of 4-OH Tamoxifen: Development, Characterization and Evaluation.

J Liposome Res 2020 Jul 10:1-38. Epub 2020 Jul 10.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.

The anti-inflammatory property of ratite oils as well as its ability to act as a penetration enhancer makes it an ideal agent to be used in transdermal formulations. The present study aims to develop an effective transfersomal delivery of 4-hydroxytamoxifen, an anti-cancer drug, using ratite oil as a carrier agent for the treatment of breast cancer. The 4-hydroxytamoxifen transfersomes were prepared with and without ratite oils using soy phosphatidylcholine and three different edge activators in five different molar ratios using the rotary evaporation-ultrasonication method. Read More

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http://dx.doi.org/10.1080/08982104.2020.1777155DOI Listing

Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man.

Oman Med J 2020 May 30;35(3):e134. Epub 2020 Jun 30.

Islamabad Diagnostic Center, Islamabad, Pakistan.

Type B insulin resistance syndrome (TBIRS) has not been previously reported in Arab populations. We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. Read More

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http://dx.doi.org/10.5001/omj.2020.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335451PMC

Determining the effectiveness of peer-assisted learning in medical education: A systematic review and meta-analysis.

J Taibah Univ Med Sci 2020 Jun 30;15(3):177-184. Epub 2020 May 30.

College of Medicine & Medical Education Center, University of Sharjah, Sharjah, United Arab Emirates.

Objective: Despite the popularity of peer-assisted learning (PAL), existing literature has not shown enough evidence that can validate its impact on students' active learning. This meta-analysis aims to quantitatively analyse the effectiveness of PAL in medical education.

Methods: We searched selected databases using the Medical Subject Headings (MeSH) terms 'peer-assisted', 'learning', 'active learning', 'teaching strategy', 'peer mentoring', and 'peer instructions' for full-text English language studies with a pre-post design. Read More

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http://dx.doi.org/10.1016/j.jtumed.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336023PMC

Magnetism in drug delivery: The marvels of iron oxides and substituted ferrites nanoparticles.

Saudi Pharm J 2020 Jul 15;28(7):876-887. Epub 2020 May 15.

Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

In modern drug delivery, seeking a drug delivery system (DDS) with a modifiable skeleton for proper targeting of loaded actives to specific sites in the body is of extreme importance for a successful therapy. Magnetically guided nanosystems, where particles such as iron oxides are guided to specific regions using an external magnetic field, can provide magnetic resonance imaging (MRI) while delivering a therapeutic payload at the same time, which represents a breakthrough in disease therapy and make MNPs excellent candidates for several biomedical applications. In this review, magnetic nanoparticles (MNPs) along with their distinguishable properties, including pharmacokinetics and toxicity, especially in cancer therapy will be discussed. Read More

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http://dx.doi.org/10.1016/j.jsps.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335713PMC

Perceptual metacognition of human faces is causally supported by function of the lateral prefrontal cortex.

Commun Biol 2020 Jul 9;3(1):360. Epub 2020 Jul 9.

Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.

Metacognitive awareness-the ability to know that one is having a particular experience-is thought to guide optimal behavior, but its neural bases continue to be the subject of vigorous debate. Prior work has identified correlations between perceptual metacognitive ability and the structure and function of lateral prefrontal cortex (LPFC); however, evidence for a causal role of this region in promoting metacognition is controversial. Moreover, whether LPFC function promotes metacognitive awareness of perceptual and emotional features of complex, yet ubiquitous face stimuli is unknown. Read More

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http://dx.doi.org/10.1038/s42003-020-1049-3DOI Listing

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.

Science 2020 Jul;369(6500):202-207

Molecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level. We describe five patients from four families with immunodeficiency coupled with atopy, lymphoproliferation, and cytokine overproduction harboring mutations in , which encodes the hematopoietic-specific HEM1 protein. These mutations cause the loss of the HEM1 protein and the WAVE regulatory complex (WRC) or disrupt binding to the WRC regulator, Arf1, thereby impairing actin polymerization, synapse formation, and immune cell migration. Read More

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http://dx.doi.org/10.1126/science.aay5663DOI Listing

Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor.

Eur Neuropsychopharmacol 2020 Jul 6. Epub 2020 Jul 6.

Division of Biochemistry, Department of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland.

Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. However, the exact role of let-7d miRNA in regulating ethanol intake and preference remains to be elucidated. The aim of the present study was to clarify the role of accumbal let-7d in controlling ethanol-related behaviors in adult rats. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2020.06.011DOI Listing

Remediation of learners struggling with communication skills: a systematic review.

BMC Med Educ 2020 Jul 9;20(1):215. Epub 2020 Jul 9.

Medical Education and Continuing Professional Development, Weill Cornell Medicine - Qatar, Doha, Qatar.

Background: Communication skills is a core area of competency for healthcare practitioners. However, trainees deficient in those skills are not identified early enough to address the deficiency. Furthermore, faculty often struggle to identify effective remediation strategies for those who fail to meet expectations. Read More

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http://dx.doi.org/10.1186/s12909-020-02074-9DOI Listing

Human campylobacteriosis related to cross-contamination during handling of raw chicken meat: Application of quantitative risk assessment to guide intervention scenarios analysis in the Australian context.

Int J Food Microbiol 2020 Jun 30;332:108775. Epub 2020 Jun 30.

Department of Health Western Australia, 189 Royal Street, East Perth, Western Australia 6004, Australia.

Quantitative Microbiological Risk Assessment (QMRA) is a methodology used to organize and analyze scientific information to both estimate the probability and severity of an adverse event as well as prioritize efforts to reduce the risk of foodborne pathogens. No QMRA efforts have been applied to Campylobacter in the Australian chicken meat sector. Hence, we present a QMRA model of human campylobacteriosis related to the occurrence of cross-contamination while handling raw chicken meat in Western Australia (WA). Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108775DOI Listing

Van der Knaap Disease (Vanishing White Matter) - Unusual Presentation in a Neonate: A Case Report.

Neurol India 2020 May-Jun;68(3):669-672

RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras al Khaimah, United Arab Emirates.

Van der Knaap disease, also known as megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a rare autosomal disorder, with no exact prevalence but more than 150 cases were reported in the literature. It was more prevalent in some ethnicities where consanguinity is common. It is usually characterized by infantile-onset macrocephaly, cerebral leukoencephalopathy and mild neurological symptoms, and a slow course of functional deterioration. Read More

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http://dx.doi.org/10.4103/0028-3886.289018DOI Listing

Symptoms of Internet Gaming Disorder, Inattention, and Impulsivity: a Cross-Sectional Study Conducted in the United Arab Emirates.

Authors:
Zahir Vally

Psychiatr Q 2020 Jul 8. Epub 2020 Jul 8.

Department of Cognitive Sciences, United Arab Emirates University, P. O. Box 1551, Al Ain, UAE.

The addictive use of internet video games is now recognized as a valid diagnostic construct by both the World Health Organization and the American Psychiatric Association. A burgeoning body of preliminary evidence points to a relationship between attention deficit and hyperactivity disorder (ADHD) symptoms as being a risk factor for behaviors indicative of internet gaming disorder (IGD), however, studies have rarely examined ADHD's two diagnostic constructs, inattention and impulsivity, separately. Moreover, IGD research is non-existent in Middle Eastern contexts. Read More

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http://dx.doi.org/10.1007/s11126-020-09799-2DOI Listing

Development of the Breast Cancer Stigma Scale for Arab Patients.

Asia Pac J Oncol Nurs 2020 Jul-Sep;7(3):295-300. Epub 2020 Jun 26.

School of Nursing Boston College, Chestnut Hill, MA, USA.

Objective: Health-related stigma is associated with depression, but there is a lack of studies examining the stigma of cancer in Arab patients. The purpose of this study was to establish the reliability and validity of a newly developed, culturally sensitive measure of stigma among Arab women with breast cancer.

Methods: The sample consisted of 59 Arab women with breast cancer who were Muslim, on active oncology treatment. Read More

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http://dx.doi.org/10.4103/apjon.apjon_14_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325776PMC

Preclerkship medical students' perceptions of medical professionalism in the College of Medicine-University of Sharjah: A vision to sustain success in medical education.

J Educ Health Promot 2020 28;9:119. Epub 2020 May 28.

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, Buckinghamshire, UK.

Introduction: Professionalism is an essential theme in both undergraduate and postgraduate medical education. The current study aimed to assess the preclerkship medical students' perception on medical professionalism.

Methods: A cross-sectional qualitative study using the critical incident technique was conducted at the University of Sharjah in the United Arab Emirates (UAE). Read More

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http://dx.doi.org/10.4103/jehp.jehp_556_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325759PMC

Assessment of lifestyle modifications among Sudanese individuals with diabetes: The situation so far and the need to do more.

J Educ Health Promot 2020 28;9:107. Epub 2020 May 28.

Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eagelstone, Milton Keynes, Buckinghamshire, UK.

Background: Inadequate lifestyle practices among individuals with diabetes may influence the progression of diabetes and its complications. The aim of this study was to assess the lifestyle practices among individuals with diabetes in Sudan.

Methodology: This was a descriptive, cross-sectional, health facility-based study conducted in 3 diabetes centers treating individuals with diabetes. Read More

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http://dx.doi.org/10.4103/jehp.jehp_151_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325792PMC

Minimally Invasive Surfactant Therapy: An Analytical Report of Our Prospective Dubai Cohort.

Cureus 2020 Jun 5;12(6):e8455. Epub 2020 Jun 5.

Neonatology, Medeor Hospital, Dubai, ARE.

Introduction:  Type 2 pneumocytes of the respiratory epithelium secrete the endogenous surfactant, a detergent-like substance that lines the alveolar sacs of the lungs. The surfactant facilitates the gas exchange process across the alveolar membrane by preventing the collapse of the alveoli and thereby maintaining their distended state. Respiratory distress syndrome of the premature neonates is characterized by quantitative and/or qualitative defects of endogenous surfactant metabolic pathways. Read More

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http://dx.doi.org/10.7759/cureus.8455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336671PMC

Critical phenomena in the temperature-pressure-crowding phase diagram of a protein.

Phys Rev X 2019 Oct-Dec;9(4). Epub 2019 Nov 18.

University of Houston, Department of Physics, Houston, Texas, 77204, United States.

In the cell, proteins fold and perform complex functions through global structural rearrangements. Function requires a protein to be at the brink of stability to be susceptible to small environmental fluctuations, yet stable enough to maintain structural integrity. These apparently conflicting behaviors are exhibited by systems near a critical point, where distinct phases merge-a concept beyond previous studies indicating proteins have a well-defined folded/unfolded phase boundary in the pressure-temperature plane. Read More

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http://dx.doi.org/10.1103/physrevx.9.041035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343146PMC
November 2019

Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization.

Iran J Pharm Res 2019 ;18(3):1180-1195

Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.

Many herbs and spices have been recommended traditionally as galactagogues and several commercial formulations prepared using herbs. Due to the presence of various compounds such as polyphenols, flavonoids, isoflavones, and terpenes, bitter and stringent taste is elicited that make the consumption of these herbal preparations unpleasant. Moreover, these compounds are unstable when exposed to environmental conditions. Read More

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http://dx.doi.org/10.22037/ijpr.2019.1100776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934978PMC
January 2019

Colorectal cancer awareness and its predictors among adults aged 50-74 years attending primary healthcare in the State of Qatar: a cross-sectional study.

BMJ Open 2020 Jul 7;10(7):e035651. Epub 2020 Jul 7.

Department of Workforce Training, Primary Health Care Corporation, Doha, Qatar.

Objective: The current study aimed to assess the awareness of colorectal cancer (CRC) symptoms and risk factors among the at-risk population visiting the primary healthcare (PHC) centres in Qatar. The secondary objective was to assess the differences in awareness among population subgroups.

Design: A cross-sectional study design was employed. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342467PMC

Elo Method and Race Traits: A New Integrated System for Sport Horse Genetic Evaluation.

Animals (Basel) 2020 Jul 6;10(7). Epub 2020 Jul 6.

Department of Veterinary Medicine-Sportive Horse Research Center, University of Perugia, via S.Costanzo 4, 06123 Perugia, Italy.

This first survey on Sardinian Anglo-Arab horse (SAA) race traits highlights important aspects for the breeding purpose of this population. The heritability of the race traits were estimated through a trivariate model; the estimates were 0.39, 0. Read More

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http://dx.doi.org/10.3390/ani10071145DOI Listing

Arabs, Whiteness, and Health Disparities: The Need for Critical Race Theory and Data.

Am J Public Health 2020 Aug;110(8):e2-e3

The authors are with The Center for the Study of Racism, Social Justice and Health, Department of Community Health Sciences, Fielding School of Public Health, University of California, Los Angeles.

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http://dx.doi.org/10.2105/AJPH.2020.305749DOI Listing

Empowering microfluidics by micro-3D printing and solution-based mineral coating.

Soft Matter 2020 Jul 8. Epub 2020 Jul 8.

Department of Mechanical Engineering, Masdar Institute, Khalifa University of Science and Technology, P. O. Box 54224, Abu Dhabi, United Arab Emirates.

Fluid-solid interaction in porous materials is of tremendous importance to earth, space, energy, environment, biological, and medical applications. High-resolution 3D printing enables efficient fabrication of porous microfluidic devices with complicated pore-throat morphology, but lacking desired surface functionality. In this work, we propose a novel approach to additively fabricate functional porous devices by integrating micro-3D printing and solution-based internal coating. Read More

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http://dx.doi.org/10.1039/d0sm00958jDOI Listing

Systematic review with meta-analysis: liver manifestations and outcomes in COVID-19.

Aliment Pharmacol Ther 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.

Background: The incidence of elevated liver chemistries and the presence of the pre-existing chronic liver disease (CLD) have been variably reported in COVID-19.

Aims: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.

Methods: A comprehensive search of electronic databases from 1 December 2019 to 24 April 2020 was done. Read More

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http://dx.doi.org/10.1111/apt.15916DOI Listing

People with type 1 diabetes and impaired awareness of hypoglycaemia have a delayed reaction to performing a glucose scan during hypoglycaemia: a prospective observational study.

Diabet Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Aim: Considering that people with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) have a delayed perception of hypoglycaemia, the question arises whether they perform scans later in case of hypoglycaemia than people without IAH. We assessed whether time to performing a scan after reaching hypoglycaemia while using a flash glucose monitoring (flash GM) system is different in people with IAH compared with people without IAH.

Methods: Ninety-two people with type 1 diabetes [mean (± sd) age 42 ± 14 years, HbA 57 ± 9 mmol/mol] using a flash GM system for 3 months were included. Read More

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http://dx.doi.org/10.1111/dme.14362DOI Listing

Assessing dietary and lifestyle risk behaviours and their associations with disease comorbidities among patients with depression: A case-control study from Bahrain.

Heliyon 2020 Jun 26;6(6):e04323. Epub 2020 Jun 26.

Ministry of Health, Manama, Bahrain.

Objectives: In Western populations, patients with depression die 10-25 years prematurely compared to controls, mainly due to lifestyle-related diseases. Tobacco smoking, excessive alcohol intake, poor diets and physical inactivity are among the major contributors to disease comorbidities. The objective of this research is to assess the dietary and lifestyle behaviours for Bahraini patients with depression and to determine their associations with different medical comorbidities. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327261PMC

Contemporary Management of Clinically Non-functioning Pituitary Adenomas: A Clinical Review.

Clin Med Insights Endocrinol Diabetes 2020 24;13:1179551420932921. Epub 2020 Jun 24.

Department of Medicine, Dubai Medical College, Dubai, United Arab Emirates.

Non-functioning pituitary adenomas (NFPAs) are benign pituitary tumours that constitute about one-third of all pituitary adenomas. They typically present with symptoms of mass effects resulting in hypopituitarism, visual symptoms, or headache. Most NFPAs are macroadenomas (>1 cm in diameter) at diagnosis that can occasionally grow quite large and invade the cavernous sinus causing acute nerve compression and some patients may develop acute haemorrhage due to pituitary apoplexy. Read More

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http://dx.doi.org/10.1177/1179551420932921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318824PMC

Effectiveness of Breast and Eye Shielding During Cervical Spine Radiography: An Experimental Study.

Risk Manag Healthc Policy 2020 30;13:697-704. Epub 2020 Jun 30.

Medical Diagnostic Imaging Department, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Purpose: This study assessed the effectiveness of breast and eye shielding and measured the radiation dose to radiosensitive tissues (eyes and breasts) due to scatter radiation during cervical spine X-ray radiography examinations.

Methods: Using an anthropomorphic phantom, the scattered radiation dose was measured before and after the placement of the lead shield over the eyes and breasts in the anteroposterior (AP) and left lateral projection. A regression formula was utilized to determine the exposure. Read More

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http://dx.doi.org/10.2147/RMHP.S257185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335279PMC

Sensitive and rapid lateral-flow assay for early detection of subclinical mammary infection in dairy cows.

Sci Rep 2020 Jul 7;10(1):11161. Epub 2020 Jul 7.

Lactation and Immuno-Physiology Laboratory, ICAR-National Dairy Research Institute, Karnal, Haryana, 132 001, India.

Detection of subclinical mastitis (SCM) in its initial stage can save great economic losses, improve milk quality and animal welfare. We have developed a semiquantitative lateral flow assay for the detection of SCM in dairy cows targeting myeloperoxidase (MPO) enzyme of milk neutrophils. A competitive immunoassay format was used, and colloidal gold nanoparticles (GNP) were prepared and used as a labelling agent. Read More

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http://dx.doi.org/10.1038/s41598-020-68174-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341798PMC

Strength of the association between Turner syndrome and coeliac disease: protocol for a systematic review and meta-analysis.

BMJ Open 2020 Jul 6;10(7):e037478. Epub 2020 Jul 6.

Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

Introduction: Coeliac disease (CD) is a genetic autoimmune disorder characterised by a permanent sensitivity to the gluten contained in some grains. Certain patient groups are considered high risk for the development of CD, including, but not limited to, those with chromosomal disorders such as Turner syndrome (TS). Here, we present a protocol for a systematic review and meta-analysis that aims to comprehensively summarise the literature, and quantitatively estimate the weighted strength of the association between TS and CD. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342855PMC

Resuscitative hysterotomy for maternal collapse in a triplet pregnancy.

BMJ Case Rep 2020 Jul 6;13(7). Epub 2020 Jul 6.

Department of Obstetrics and Gynecology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab Emirates.

We encountered a 47-year-old woman, at 35 weeks of gestation, carrying triplets, who attended the hospital with severe pre-eclampsia and at admission had eclamptic fit followed by cardiac arrest. Cardiopulmonary resuscitation was started when she did not respond to initial measures; resuscitative hysterotomy was started on the site of collapse immediately, within 4 min postarrest, to deliver the triplets within 5 min postmaternal cardiac arrest. Timely decision of resuscitative hysterotomy done primarily to restore maternal cardiac output due to a grossly gravid uterus saved the mother and the triplets. Read More

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http://dx.doi.org/10.1136/bcr-2020-235328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342181PMC

Possible metabolic conversion of pinene to ionone.

Pharmazie 2020 Jul;75(7):360-363

College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates; Herbert Wertheim College of Medicine, Florida International University, Miami, USA;, Email:

The unintended consequence of the ingestion of certain foods to alter the scent or color of urine is well known. Less awareness exists regarding the practice of ingestion of natural products or drugs with the intended purpose of conferring urine the scent of violets. The resin of the terebinth tree and the derived turpentine were widely used in antiquity in wine-making, both as taste enhancer and conserving agent, so the effect on urine was possibly noticed due to the presence in wines. Read More

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http://dx.doi.org/10.1691/ph.2020.9925DOI Listing

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach.

J Transl Med 2020 07 7;18(1):275. Epub 2020 Jul 7.

Department of Chemistry, United Arab Emirates University, Al-Ain, UAE.

Background: The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continents. Hitherto, no antiviral drug is available to combat this viral outbreak.

Methods: Keeping in mind the urgency of the situation, the current study was designed to devise new strategies for drug discovery and/or repositioning against SARS-CoV-2. Read More

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http://dx.doi.org/10.1186/s12967-020-02439-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339606PMC

PARC report: health outcomes and value of personalized medicine interventions: impact on patient care.

Pharmacogenomics 2020 Jul 8. Epub 2020 Jul 8.

University of Patras School of Health Sciences, Department of Pharmacy, Patras, 26504, Greece.

The incorporation of personalized medicine interventions into routine healthcare constitutes an opportunity to improve patients' quality of life, as it empowers implementation of innovative, individualized clinical interventions that maximize efficacy and/or minimize the risk of adverse drug reactions. In order to ensure equal access to genomic testing for all patients, the costs associated with these interventions must be reimbursed by payers and insurance bodies. As such, it is of utmost importance to thoroughly evaluate these interventions both in terms of their clinical effectiveness and their economic cost. Read More

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http://dx.doi.org/10.2217/pgs-2019-0194DOI Listing

Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors.

J Enzyme Inhib Med Chem 2020 Dec;35(1):1483-1490

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

A series of 17 compounds () with 2,4,5-trisubstitutedthiazole scaffold having 5-aryl group, 4-carboxylic acid/ester moiety, and 2-amino/amido/ureido functional groups were synthesised, characterised, and evaluated for their carbonic anhydrase (CA)-III inhibitory activities using the size exclusion Hummel-Dreyer method (HDM) of chromatography. Compound with a free amino group at the 2-position, carboxylic acid moiety at the 4-position, and a phenyl ring at the 5-position of the scaffold was found to be the most potent CA-III inhibitor ( = 0.5 μM). Read More

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http://dx.doi.org/10.1080/14756366.2020.1786820DOI Listing
December 2020

European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.

Pediatr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: The 2020 novel coronavirus (SARS-Cov-2) pandemic necessitates tailored recommendations addressing specific procedures for neonatal and paediatric transport of suspected or positive COVID-19 patients. The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2.

Methods: A taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients. Read More

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http://dx.doi.org/10.1038/s41390-020-1050-zDOI Listing

Synthesis, characterization and application of novel MnO and CuO impregnated biochar composites to sequester arsenic (As) from water: Modeling, thermodynamics and reusability.

J Hazard Mater 2020 Jun 30;401:123338. Epub 2020 Jun 30.

Department of Environmental Sciences and Engineering, Government College University, Faisalabad, 38000, Pakistan. Electronic address:

The present study aimed at enhancing the adsorption potential of novel nanocomposites of Sesbania bispinosa biochar (SBC) with copper oxide (SBC/CuO) and manganese oxide nanoparticles (SBC/MnO) for the efficient and inexpensive removal of environmentally concerned contaminant arsenic (As) from contaminated water at batch scale. The scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, energy dispersive X-ray (EDX), X-ray diffraction (XRD) and point of zero charge (PZC) analyses proved successful impregnation of the metallic nanoparticles on SBC surface. The results revealed the maximum As removal (96 %) and adsorption (12. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123338DOI Listing